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Conserved domains on  [gi|1242013593|ref|NP_001342207|]
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centromere protein V-like protein 2 [Homo sapiens]

Protein Classification

GFA family protein( domain architecture ID 10007990)

GFA family protein similar to bacterial glutathione-dependent formaldehyde-activating enzyme, which catalyzes the condensation of formaldehyde and glutathione to S-hydroxymethylglutathione, and to eukaryotic centromere protein V, which plays a role in the distribution of pericentromeric heterochromatin in interphase nuclei

CATH:  2.170.150.70
Gene Ontology:  GO:0016846|GO:0046872

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG3791 COG3791
Uncharacterized conserved protein [Function unknown];
132-228 4.61e-23

Uncharacterized conserved protein [Function unknown];


:

Pssm-ID: 443005  Cd Length: 132  Bit Score: 91.23  E-value: 4.61e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013593 132 HHTGGCHCGAVRFAVWAPAdLRVVDCSCRLCRKKQHRHF----LVPASRFTLLQGAESIVTYRSnTHPALHSFCSRCGVQ 207
Cdd:COG3791     3 TLTGSCLCGAVRFEVDGPP-LRVGACHCSICRKATGSAFaavaLVPADAFRLTSGEDALTTYRS-SATAERHFCPTCGSP 80

                          90       100
                  ....*....|....*....|.
gi 1242013593 208 SFHAAVSDPRVYGVAPHCLDE 228
Cdd:COG3791    81 LFYRRRGGPGLVAVNAGLLDD 101
 
Name Accession Description Interval E-value
COG3791 COG3791
Uncharacterized conserved protein [Function unknown];
132-228 4.61e-23

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443005  Cd Length: 132  Bit Score: 91.23  E-value: 4.61e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013593 132 HHTGGCHCGAVRFAVWAPAdLRVVDCSCRLCRKKQHRHF----LVPASRFTLLQGAESIVTYRSnTHPALHSFCSRCGVQ 207
Cdd:COG3791     3 TLTGSCLCGAVRFEVDGPP-LRVGACHCSICRKATGSAFaavaLVPADAFRLTSGEDALTTYRS-SATAERHFCPTCGSP 80

                          90       100
                  ....*....|....*....|.
gi 1242013593 208 SFHAAVSDPRVYGVAPHCLDE 228
Cdd:COG3791    81 LFYRRRGGPGLVAVNAGLLDD 101
GFA pfam04828
Glutathione-dependent formaldehyde-activating enzyme; The GFA enzyme catalyzes the first step ...
 157-228 4.28e-07

Glutathione-dependent formaldehyde-activating enzyme; The GFA enzyme catalyzes the first step in the detoxification of formaldehyde. This domain has a beta-tent fold.


Pssm-ID: 428146  Cd Length: 93  Bit Score: 46.97  E-value: 4.28e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1242013593 157 CSCRLCRKKQHR----HFLVPASRFTLLQGAESIVTYRSNT-HPALHSFCSRCGVQSFHAAVSDPRVYGVAPHCLDE 228
Cdd:pfam04828   3 CHCRDCQRRSGSafaaNAVVPKEALRLTSGELKEYTDTGDSgNTVTRYFCPNCGTPLYSESTAAPGVIIVRVGTLDD 79
 
Name Accession Description Interval E-value
COG3791 COG3791
Uncharacterized conserved protein [Function unknown];
132-228 4.61e-23

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443005  Cd Length: 132  Bit Score: 91.23  E-value: 4.61e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1242013593 132 HHTGGCHCGAVRFAVWAPAdLRVVDCSCRLCRKKQHRHF----LVPASRFTLLQGAESIVTYRSnTHPALHSFCSRCGVQ 207
Cdd:COG3791     3 TLTGSCLCGAVRFEVDGPP-LRVGACHCSICRKATGSAFaavaLVPADAFRLTSGEDALTTYRS-SATAERHFCPTCGSP 80

                          90       100
                  ....*....|....*....|.
gi 1242013593 208 SFHAAVSDPRVYGVAPHCLDE 228
Cdd:COG3791    81 LFYRRRGGPGLVAVNAGLLDD 101
GFA pfam04828
Glutathione-dependent formaldehyde-activating enzyme; The GFA enzyme catalyzes the first step ...
 157-228 4.28e-07

Glutathione-dependent formaldehyde-activating enzyme; The GFA enzyme catalyzes the first step in the detoxification of formaldehyde. This domain has a beta-tent fold.


Pssm-ID: 428146  Cd Length: 93  Bit Score: 46.97  E-value: 4.28e-07
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1242013593 157 CSCRLCRKKQHR----HFLVPASRFTLLQGAESIVTYRSNT-HPALHSFCSRCGVQSFHAAVSDPRVYGVAPHCLDE 228
Cdd:pfam04828   3 CHCRDCQRRSGSafaaNAVVPKEALRLTSGELKEYTDTGDSgNTVTRYFCPNCGTPLYSESTAAPGVIIVRVGTLDD 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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