NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1243457501|ref|NP_001342452|]
View 

WD repeat-containing protein 31 isoform 3 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
77-250 1.91e-33

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.41  E-value: 1.91e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501  77 ISGGKDKTAVAYNWKTGRMVKRFTGHEREITKIACIPKANQFFSASRDKTVLMWDLQGSShPRQQLSGHAMVVTGLAVSP 156
Cdd:COG2319   178 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK-LLRTLTGHSGSVRSVAFSP 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501 157 DSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQTSEDKTIRLWDSRGLQMAHMFPTKQHIQTHC 236
Cdd:COG2319   257 DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                         170
                  ....*....|....
gi 1243457501 237 EVSVDGHTCISCSS 250
Cdd:COG2319   337 AFSPDGKTLASGSD 350
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
77-250 1.91e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.41  E-value: 1.91e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501  77 ISGGKDKTAVAYNWKTGRMVKRFTGHEREITKIACIPKANQFFSASRDKTVLMWDLQGSShPRQQLSGHAMVVTGLAVSP 156
Cdd:COG2319   178 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK-LLRTLTGHSGSVRSVAFSP 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501 157 DSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQTSEDKTIRLWDSRGLQMAHMFPTKQHIQTHC 236
Cdd:COG2319   257 DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                         170
                  ....*....|....
gi 1243457501 237 EVSVDGHTCISCSS 250
Cdd:COG2319   337 AFSPDGKTLASGSD 350
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 61-250 1.34e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.90  E-value: 1.34e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501  61 HVDTVSVIATL-NSDLCISGGKDKTAVAYNWKTGRMVKRFTGHEREITKIACIPKANQFFSASRDKTVLMWDLQgSSHPR 139
Cdd:cd00200     8 HTGGVTCVAFSpDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE-TGECV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501 140 QQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQTSEDKTIRLWDSRG 219
Cdd:cd00200    87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1243457501 220 LQMAHMFPTKQHIQTHCEVSVDGHTCISCSS 250
Cdd:cd00200   167 GKCVATLTGHTGEVNSVAFSPDGEKLLSSSS 197
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 135-174 7.34e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 7.34e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1243457501  135 SSHPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWD 174
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 101-218 1.96e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 48.74  E-value: 1.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501 101 GHEREITKIACIPKANQ-FFSASRDKTVLMWDL------QGSSHPRQQLSGHAMVVTGLAVSPDSSQ-LCTGSRDNSLLL 172
Cdd:PTZ00421   73 GQEGPIIDVAFNPFDPQkLFTASEDGTIMGWGIpeegltQNISDPIVHLQGHTKKVGIVSFHPSAMNvLASAGADMVVNV 152

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1243457501 173 WDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQTSEDKTIRLWDSR 218
Cdd:PTZ00421  153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPR 198
WD40 pfam00400
WD domain, G-beta repeat;
138-174 6.96e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 6.96e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1243457501 138 PRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWD 174
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
77-250 1.91e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.41  E-value: 1.91e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501  77 ISGGKDKTAVAYNWKTGRMVKRFTGHEREITKIACIPKANQFFSASRDKTVLMWDLQGSShPRQQLSGHAMVVTGLAVSP 156
Cdd:COG2319   178 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGK-LLRTLTGHSGSVRSVAFSP 256

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501 157 DSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQTSEDKTIRLWDSRGLQMAHMFPTKQHIQTHC 236
Cdd:COG2319   257 DGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSV 336

                         170
                  ....*....|....
gi 1243457501 237 EVSVDGHTCISCSS 250
Cdd:COG2319   337 AFSPDGKTLASGSD 350
WD40 COG2319
WD40 repeat [General function prediction only];
48-250 2.88e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 125.02  E-value: 2.88e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501  48 RVQTKAPQEYIPVHVDTVSVIA-TLNSDLCISGGKDKTAVAYNWKTGRMVKRFTGHEREITKIACIPKANQFFSASRDKT 126
Cdd:COG2319   106 DLATGLLLRTLTGHTGAVRSVAfSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGT 185

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501 127 VLMWDLQgSSHPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQT 206
Cdd:COG2319   186 VRLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASG 264

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....
gi 1243457501 207 SEDKTIRLWDSRGLQMAHMFPTKQHIQTHCEVSVDGHTCISCSS 250
Cdd:COG2319   265 SADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSD 308
WD40 COG2319
WD40 repeat [General function prediction only];
19-250 9.30e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.87  E-value: 9.30e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501  19 RLWAVM-GKLQSKLR-HSTYLYS---RPDG-----------IIEERVQTKAPQEYIPVHVDTVSVIA-TLNSDLCISGGK 81
Cdd:COG2319   145 RLWDLAtGKLLRTLTgHSGAVTSvafSPDGkllasgsddgtVRLWDLATGKLLRTLTGHTGAVRSVAfSPDGKLLASGSA 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501  82 DKTAVAYNWKTGRMVKRFTGHEREITKIACIPKANQFFSASRDKTVLMWDLQGSShPRQQLSGHAMVVTGLAVSPDSSQL 161
Cdd:COG2319   225 DGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGE-LLRTLTGHSGGVNSVAFSPDGKLL 303

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501 162 CTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQTSEDKTIRLWDSRGLQMAHMFPTKQHIQTHCEVSVD 241
Cdd:COG2319   304 ASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPD 383


                  ....*....
gi 1243457501 242 GHTCISCSS 250
Cdd:COG2319   384 GRTLASGSA 392
WD40 COG2319
WD40 repeat [General function prediction only];
49-216 9.30e-33

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 123.87  E-value: 9.30e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501  49 VQTKAPQEYIPVHVDTVSVIA-TLNSDLCISGGKDKTAVAYNWKTGRMVKRFTGHEREITKIACIPKANQFFSASRDKTV 127
Cdd:COG2319   233 LATGKLLRTLTGHSGSVRSVAfSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTV 312

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501 128 LMWDLQgSSHPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQTS 207
Cdd:COG2319   313 RLWDLA-TGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGS 391


                  ....*....
gi 1243457501 208 EDKTIRLWD 216
Cdd:COG2319   392 ADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 61-250 1.34e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.90  E-value: 1.34e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501  61 HVDTVSVIATL-NSDLCISGGKDKTAVAYNWKTGRMVKRFTGHEREITKIACIPKANQFFSASRDKTVLMWDLQgSSHPR 139
Cdd:cd00200     8 HTGGVTCVAFSpDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLE-TGECV 86

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501 140 QQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQTSEDKTIRLWDSRG 219
Cdd:cd00200    87 RTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRT 166

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1243457501 220 LQMAHMFPTKQHIQTHCEVSVDGHTCISCSS 250
Cdd:cd00200   167 GKCVATLTGHTGEVNSVAFSPDGEKLLSSSS 197
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 48-249 2.92e-32

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.13  E-value: 2.92e-32
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501  48 RVQTKAPQEYIPVHVDTVSVIATL-NSDLCISGGKDKTAVAYNWKTGRMVKRFTGHEREITKIACIPKANQFFSASRDKT 126
Cdd:cd00200    37 DLETGELLRTLKGHTGPVRDVAASaDGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKT 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501 127 VLMWDLQGSShPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQT 206
Cdd:cd00200   117 IKVWDVETGK-CLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSS 195

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1243457501 207 SEDKTIRLWDSRGLQMAHMFPTKQHIQTHCEVSVDGHTCISCS 249
Cdd:cd00200   196 SSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGS 238
WD40 COG2319
WD40 repeat [General function prediction only];
48-250 2.53e-31

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 120.02  E-value: 2.53e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501  48 RVQTKAPQEYIPVHVDTVSVIATLNSDLCISGGKDKTAVAYNWKTGRMVKRFTGHEREITKIACIPKANQFFSASRDKTV 127
Cdd:COG2319    65 AAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTV 144

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501 128 LMWDLQgSSHPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQTS 207
Cdd:COG2319   145 RLWDLA-TGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGS 223

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1243457501 208 EDKTIRLWDSRGLQMAHMFPTKQHIQTHCEVSVDGHTCISCSS 250
Cdd:COG2319   224 ADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSA 266
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 61-216 2.87e-31

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 117.44  E-value: 2.87e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501  61 HVDTVSVIATL-NSDLCISGGKDKTAVAYNWKTGRMVKRFTGHEREITKIACIPKANQFFSASRDKTVLMWDLQGSSHpR 139
Cdd:cd00200   134 HTDWVNSVAFSpDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKC-L 212

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1243457501 140 QQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQTSEDKTIRLWD 216
Cdd:cd00200   213 GTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 61-227 9.50e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 110.50  E-value: 9.50e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501  61 HVDTVSVIATLNSDLCI-SGGKDKTAVAYNWKTGRMVKRFTGHEREITKIAcIPKANQF-FSASRDKTVLMWDLQgSSHP 138
Cdd:cd00200    92 HTSYVSSVAFSPDGRILsSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVA-FSPDGTFvASSSQDGTIKLWDLR-TGKC 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501 139 RQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQTSEDKTIRLWDSR 218
Cdd:cd00200   170 VATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLR 249


                  ....*....
gi 1243457501 219 GLQMAHMFP 227
Cdd:cd00200   250 TGECVQTLS 258
WD40 COG2319
WD40 repeat [General function prediction only];
59-251 1.24e-25

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 104.22  E-value: 1.24e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501  59 PVHVDTVSVIATLNSDLCISGGKDKTAVAYNWKTGRMVKRFTGHEREITKIACIPKANQFFSASRDKTVLMWDLQGSsHP 138
Cdd:COG2319    34 GLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATG-LL 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501 139 RQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQTSEDKTIRLWDSR 218
Cdd:COG2319   113 LRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLA 192

                         170       180       190
                  ....*....|....*....|....*....|...
gi 1243457501 219 GLQMAHMFPTKQHIQTHCEVSVDGHTCISCSSG 251
Cdd:COG2319   193 TGKLLRTLTGHTGAVRSVAFSPDGKLLASGSAD 225
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 95-245 2.54e-23

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 96.25  E-value: 2.54e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501  95 MVKRFTGHEREITKIACIPKANQFFSASRDKTVLMWDLQGSSHPRqQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWD 174
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLR-TLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1243457501 175 VGTGQCVERASVSRNLVTHLCWVPSEPYIVQTSEDKTIRLWDsrglqmahmFPTKQhiqthCEVSVDGHTC 245
Cdd:cd00200    80 LETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD---------VETGK-----CLTTLRGHTD 136
WD40 COG2319
WD40 repeat [General function prediction only];
48-177 2.56e-23

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 98.06  E-value: 2.56e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501  48 RVQTKAPQEYIPVHVDTVSVIA-TLNSDLCISGGKDKTAVAYNWKTGRMVKRFTGHEREITKIACIPKANQFFSASRDKT 126
Cdd:COG2319   274 DLATGELLRTLTGHSGGVNSVAfSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKTLASGSDDGT 353

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1243457501 127 VLMWDLQGSShPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGT 177
Cdd:COG2319   354 VRLWDLATGE-LLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 138-250 4.60e-14

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.44  E-value: 4.60e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501 138 PRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQTSEDKTIRLWDS 217
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1243457501 218 RGLQMAHMFptKQHIQ--THCEVSVDGHTCISCSS 250
Cdd:cd00200    81 ETGECVRTL--TGHTSyvSSVAFSPDGRILSSSSR 113
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 135-174 7.34e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 45.00  E-value: 7.34e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1243457501  135 SSHPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWD 174
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 COG2319
WD40 repeat [General function prediction only];
113-250 1.13e-06

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 49.14  E-value: 1.13e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501 113 PKANQFFSASRDKTVLMWDLQGSSHPRQQLsGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERASVSRNLVT 192
Cdd:COG2319     4 ADGAALAAASADLALALLAAALGALLLLLL-GLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVL 82

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1243457501 193 HLCWVPSEPYIVQTSEDKTIRLWDSRGLQMAHMFPTKQHIQTHCEVSVDGHTCISCSS 250
Cdd:COG2319    83 SVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSA 140
PTZ00421 PTZ00421
coronin; Provisional
 101-218 1.96e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 48.74  E-value: 1.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501 101 GHEREITKIACIPKANQ-FFSASRDKTVLMWDL------QGSSHPRQQLSGHAMVVTGLAVSPDSSQ-LCTGSRDNSLLL 172
Cdd:PTZ00421   73 GQEGPIIDVAFNPFDPQkLFTASEDGTIMGWGIpeegltQNISDPIVHLQGHTKKVGIVSFHPSAMNvLASAGADMVVNV 152

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1243457501 173 WDVGTGQCVERASVSRNLVTHLCWVPSEPYIVQTSEDKTIRLWDSR 218
Cdd:PTZ00421  153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPR 198
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 92-131 6.52e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 42.30  E-value: 6.52e-06
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1243457501   92 TGRMVKRFTGHEREITKIACIPKANQFFSASRDKTVLMWD 131
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 101-221 6.77e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 46.81  E-value: 6.77e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1243457501 101 GHEREITKIACIPKANQFF-SASRDKTVLMWDLQgSSHPRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQ 179
Cdd:PTZ00421  123 GHTKKVGIVSFHPSAMNVLaSAGADMVVNVWDVE-RGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGT 201

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*..
gi 1243457501 180 CVERASVSRNLVTHLC-WVPSEPYIV----QTSEDKTIRLWDSRGLQ 221
Cdd:PTZ00421  202 IVSSVEAHASAKSQRClWAKRKDLIItlgcSKSQQRQIMLWDTRKMA 248
WD40 pfam00400
WD domain, G-beta repeat;
138-174 6.96e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 6.96e-06
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1243457501 138 PRQQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWD 174
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
93-131 1.02e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.87  E-value: 1.02e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1243457501  93 GRMVKRFTGHEREITKIACIPKANQFFSASRDKTVLMWD 131
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 140-196 1.75e-04

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 42.37  E-value: 1.75e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1243457501 140 QQLSGHAMVVTGLAVSPDSSQLCTGSRDNSLLLWDVGTGQCVERAsvSRNLVTHLCW 196
Cdd:pfam20426 118 QSIRQHKDVVSCVAVTSDGSILATGSYDTTVMVWEVLRGRSSEKR--SRNTQTEFPR 172
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 177-216 2.33e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 2.33e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1243457501  177 TGQCVERASVSRNLVTHLCWVPSEPYIVQTSEDKTIRLWD 216
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
178-216 3.10e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 34.63  E-value: 3.10e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1243457501 178 GQCVERASVSRNLVTHLCWVPSEPYIVQTSEDKTIRLWD 216
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH