NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1246742890|ref|NP_001342836|]
View 

vitatmin B6 import carrier Bsu1 [Schizosaccharomyces pombe]

Protein Classification

MFS transporter( domain architecture ID 13023297)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 84-507 2.65e-119

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 355.73  E-value: 2.65e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890  84 VFMFCLMQIYVIWTSNGFGSIEYSVMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNIS 163
Cdd:cd17323     1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 164 CALPRNIVQMIISHFIIGVAGSTALTNVAGGIPDLFPEDTAGVPMSLFVWACAGGAIGAPMATGVdINAKYGWRWLYYIN 243
Cdd:cd17323    81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGF-ITQSLGWRWIFWFL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 244 IIVGGFFLIVILIIPetlpikvitryenakgrivegipknnlkevlkkckfvttmgfrmmltePIILSMGLYNFYAYGIS 323
Cdd:cd17323   160 AIISGFCLILIFLFL------------------------------------------------PIVLLLGLYVGLVYAIL 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 324 YFFLTAIWPVFYDTYKMSEMGASCTYLSGFVASTLLFLYQPIQ-DWIFRRDKAKNNGVARPEARFTSALFITLLFPAGMF 402
Cdd:cd17323   192 YLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLsDYYYRRLKKKNGGKPEPEARLPPAFIGAFLFPIGLF 271

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 403 LFAFTCHPPFPWMSPIVGNSMVTVANGHNWMCILNYLTDSYPLLSGSAVAAFTLPSFIGATVFAHVSQIMFNNMSVKWAV 482
Cdd:cd17323   272 IFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNLGVGWAF 351

                         410       420
                  ....*....|....*....|....*
gi 1246742890 483 ATMAFISISIPFIIYTFYFFGQRIR 507
Cdd:cd17323   352 TLLAFISLAMIPIPFIFYKYGKKIR 376
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 84-507 2.65e-119

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 355.73  E-value: 2.65e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890  84 VFMFCLMQIYVIWTSNGFGSIEYSVMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNIS 163
Cdd:cd17323     1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 164 CALPRNIVQMIISHFIIGVAGSTALTNVAGGIPDLFPEDTAGVPMSLFVWACAGGAIGAPMATGVdINAKYGWRWLYYIN 243
Cdd:cd17323    81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGF-ITQSLGWRWIFWFL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 244 IIVGGFFLIVILIIPetlpikvitryenakgrivegipknnlkevlkkckfvttmgfrmmltePIILSMGLYNFYAYGIS 323
Cdd:cd17323   160 AIISGFCLILIFLFL------------------------------------------------PIVLLLGLYVGLVYAIL 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 324 YFFLTAIWPVFYDTYKMSEMGASCTYLSGFVASTLLFLYQPIQ-DWIFRRDKAKNNGVARPEARFTSALFITLLFPAGMF 402
Cdd:cd17323   192 YLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLsDYYYRRLKKKNGGKPEPEARLPPAFIGAFLFPIGLF 271

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 403 LFAFTCHPPFPWMSPIVGNSMVTVANGHNWMCILNYLTDSYPLLSGSAVAAFTLPSFIGATVFAHVSQIMFNNMSVKWAV 482
Cdd:cd17323   272 IFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNLGVGWAF 351

                         410       420
                  ....*....|....*....|....*
gi 1246742890 483 ATMAFISISIPFIIYTFYFFGQRIR 507
Cdd:cd17323   352 TLLAFISLAMIPIPFIFYKYGKKIR 376
2_A_01_02 TIGR00880
Multidrug resistance protein;
124-260 2.77e-35

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 128.92  E-value: 2.77e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 124 SMNILGSGLGPMFLGPLS----DIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGSTALTNVAGGIPDLF 199
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSglltDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1246742890 200 PEDTAGVPMSLFVWACAGGAIGAPMATGVDInAKYGWRWLYYINIIVGGFFLIVIL-IIPET 260
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLA-QFLGWRAPFLFLAILALAAFILLAfLLPET 141
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
108-464 4.09e-21

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 94.66  E-value: 4.09e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 108 VMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGSTA 187
Cdd:COG2814    36 IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGAL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 188 LTNVAGGIPDLFPEDTAGVPMSLFVWACAGGAIGAPMATGVdINAKYGWRWLYYINIIVG-GFFLIVILIIPETLPIKvi 266
Cdd:COG2814   116 FPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL-LADLFGWRWVFLVNAVLAlLALLLLLRLLPESRPAA-- 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 267 tryenaKGRIVEgipknnlkevlkkckfvttmGFRMMLTEPIILSMGLYNFyAYGISYFFLTAIWPVFY-DTYKMSEMGA 345
Cdd:COG2814   193 ------RARLRG--------------------SLRELLRRPRLLLLLLLAF-LLGFGFFALFTYLPLYLqEVLGLSASAA 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 346 SCTYLSGFVASTLL-FLYQPIQDWIFRRdkaknngvarpearfTSALFITLLFPAGMFLFAFTchPPFPWMspIVGNSMV 424
Cdd:COG2814   246 GLLLALFGLGGVLGaLLAGRLADRFGRR---------------RLLLIGLLLLALGLLLLALA--GSLWLL--LLALFLL 306

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1246742890 425 TVANGHNWMCILNYLTDSYPL-LSGSAVAAFTLPSFIGATV 464
Cdd:COG2814   307 GFGFGLLFPLLQALVAELAPPeARGRASGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
82-466 6.44e-21

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 94.02  E-value: 6.44e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890  82 SIVFMFCLMQIYVIWTSngfgsIEYSVMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFN 161
Cdd:pfam07690   2 FLAAFLAALGRSLLGPA-----LPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 162 ISCALPRNIVQMIISHFIIGVAGSTALTNVAGGIPDLFPEDTAGVPMSLFVWACAGGAIGAPMATGVdINAKYGWRWLYY 241
Cdd:pfam07690  77 LLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGL-LASLFGWRAAFL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 242 INIIVGGFFLIVILIIPETLPIKVITRYENAKGRIVEgipknnlkevlkkckfvttmGFRMMLTEPIILsmGLYNFYAYG 321
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIV--------------------AWKALLRDPVLW--LLLALLLFG 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 322 ISYFFLTAIWPVFYDTYKMSEMGASCTYlsgFVASTLLFLYQPIQDWIFRRdkaknngvARPEARFTSALFITLLFPAGM 401
Cdd:pfam07690 214 FAFFGLLTYLPLYQEVLGLSALLAGLLL---GLGGLLGAIGRLLLGRLSDR--------LGRRRRLLLALLLLILAALGL 282

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246742890 402 FLFAFTCHPPFPWMSPIvgnsMVTVANGHNWMCILNYLTDSYPL-LSGSAVAAFTLPSFIGATVFA 466
Cdd:pfam07690 283 LLLSLTLSSLWLLLALL----LLGFGFGLVFPALNALVSDLAPKeERGTASGLYNTAGSLGGALGP 344
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
110-262 3.58e-12

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 68.02  E-value: 3.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 110 AQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGSTALT 189
Cdd:PRK11102   19 ADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASV 98

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1246742890 190 NVAGGIPDLFPEDTAGVPMSLFVWACAGGAIGAPMATGVdINAKYGWRWLYYINIIVGGF-FLIVILIIPETLP 262
Cdd:PRK11102   99 VINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGW-LLVWFSWHAIFWVLALAAILaAALVFFFIPETLP 171
 
Name Accession Description Interval E-value
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 84-507 2.65e-119

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 355.73  E-value: 2.65e-119
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890  84 VFMFCLMQIYVIWTSNGFGSIEYSVMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNIS 163
Cdd:cd17323     1 VFIISFLTFVVTFGSSIYSPALPQIAEDFHVSEEVANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIG 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 164 CALPRNIVQMIISHFIIGVAGSTALTNVAGGIPDLFPEDTAGVPMSLFVWACAGGAIGAPMATGVdINAKYGWRWLYYIN 243
Cdd:cd17323    81 CALAPNIAMLIILRFLQGFFGSSPLAIGAGTIADLFTPEERGKAMGVYSLGPLLGPALGPIIGGF-ITQSLGWRWIFWFL 159

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 244 IIVGGFFLIVILIIPetlpikvitryenakgrivegipknnlkevlkkckfvttmgfrmmltePIILSMGLYNFYAYGIS 323
Cdd:cd17323   160 AIISGFCLILIFLFL------------------------------------------------PIVLLLGLYVGLVYAIL 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 324 YFFLTAIWPVFYDTYKMSEMGASCTYLSGFVASTLLFLYQPIQ-DWIFRRDKAKNNGVARPEARFTSALFITLLFPAGMF 402
Cdd:cd17323   192 YLFLTAFPYVFGEVYGFSPGEVGLMYLPIGIGALIGSIIGGRLsDYYYRRLKKKNGGKPEPEARLPPAFIGAFLFPIGLF 271

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 403 LFAFTCHPPFPWMSPIVGNSMVTVANGHNWMCILNYLTDSYPLLSGSAVAAFTLPSFIGATVFAHVSQIMFNNMSVKWAV 482
Cdd:cd17323   272 IFGWTIYPHIHWIVPIIGSAFFGFGLMLIFQSSLTYLVDSYPKYAASALAANTLVRSIFAAIFPLFAQPMFNNLGVGWAF 351

                         410       420
                  ....*....|....*....|....*
gi 1246742890 483 ATMAFISISIPFIIYTFYFFGQRIR 507
Cdd:cd17323   352 TLLAFISLAMIPIPFIFYKYGKKIR 376
2_A_01_02 TIGR00880
Multidrug resistance protein;
124-260 2.77e-35

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 128.92  E-value: 2.77e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 124 SMNILGSGLGPMFLGPLS----DIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGSTALTNVAGGIPDLF 199
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSglltDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGAALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1246742890 200 PEDTAGVPMSLFVWACAGGAIGAPMATGVDInAKYGWRWLYYINIIVGGFFLIVIL-IIPET 260
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLA-QFLGWRAPFLFLAILALAAFILLAfLLPET 141
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
108-464 4.09e-21

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 94.66  E-value: 4.09e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 108 VMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGSTA 187
Cdd:COG2814    36 IAADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGAL 115

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 188 LTNVAGGIPDLFPEDTAGVPMSLFVWACAGGAIGAPMATGVdINAKYGWRWLYYINIIVG-GFFLIVILIIPETLPIKvi 266
Cdd:COG2814   116 FPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGL-LADLFGWRWVFLVNAVLAlLALLLLLRLLPESRPAA-- 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 267 tryenaKGRIVEgipknnlkevlkkckfvttmGFRMMLTEPIILSMGLYNFyAYGISYFFLTAIWPVFY-DTYKMSEMGA 345
Cdd:COG2814   193 ------RARLRG--------------------SLRELLRRPRLLLLLLLAF-LLGFGFFALFTYLPLYLqEVLGLSASAA 245

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 346 SCTYLSGFVASTLL-FLYQPIQDWIFRRdkaknngvarpearfTSALFITLLFPAGMFLFAFTchPPFPWMspIVGNSMV 424
Cdd:COG2814   246 GLLLALFGLGGVLGaLLAGRLADRFGRR---------------RLLLIGLLLLALGLLLLALA--GSLWLL--LLALFLL 306

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1246742890 425 TVANGHNWMCILNYLTDSYPL-LSGSAVAAFTLPSFIGATV 464
Cdd:COG2814   307 GFGFGLLFPLLQALVAELAPPeARGRASGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
82-466 6.44e-21

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 94.02  E-value: 6.44e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890  82 SIVFMFCLMQIYVIWTSngfgsIEYSVMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFN 161
Cdd:pfam07690   2 FLAAFLAALGRSLLGPA-----LPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGL 76

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 162 ISCALPRNIVQMIISHFIIGVAGSTALTNVAGGIPDLFPEDTAGVPMSLFVWACAGGAIGAPMATGVdINAKYGWRWLYY 241
Cdd:pfam07690  77 LLLLFASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGL-LASLFGWRAAFL 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 242 INIIVGGFFLIVILIIPETLPIKVITRYENAKGRIVEgipknnlkevlkkckfvttmGFRMMLTEPIILsmGLYNFYAYG 321
Cdd:pfam07690 156 ILAILSLLAAVLLLLPRPPPESKRPKPAEEARLSLIV--------------------AWKALLRDPVLW--LLLALLLFG 213

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 322 ISYFFLTAIWPVFYDTYKMSEMGASCTYlsgFVASTLLFLYQPIQDWIFRRdkaknngvARPEARFTSALFITLLFPAGM 401
Cdd:pfam07690 214 FAFFGLLTYLPLYQEVLGLSALLAGLLL---GLGGLLGAIGRLLLGRLSDR--------LGRRRRLLLALLLLILAALGL 282

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246742890 402 FLFAFTCHPPFPWMSPIvgnsMVTVANGHNWMCILNYLTDSYPL-LSGSAVAAFTLPSFIGATVFA 466
Cdd:pfam07690 283 LLLSLTLSSLWLLLALL----LLGFGFGLVFPALNALVSDLAPKeERGTASGLYNTAGSLGGALGP 344
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 77-361 5.44e-19

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 87.56  E-value: 5.44e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890  77 WAKRWSIVFMFCLMQIYVIWTSNGFGSIEYSVMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFV 156
Cdd:COG0477     9 TRRRRRALLALALGTFLEGLDFTIVNVALPSIAADLGASSAQLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 157 YTVFNISCALPRNIVQMIISHFIIGVAGSTALTNVAGGIPDLFPEDTAGVPMSLFVWACAGGAIGAPMATGVdINAKYGW 236
Cdd:COG0477    89 FGLASLLCGLAPSPELLIAARALQGIGAGGLMPGALALIAELFPARERGRALGLWGAAIGLGLALGPLLGGL-LVAALGW 167

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 237 RWLYYINIIVGGFFLIVILIIPETLPIKVITRYENAKGRIVEGIpknnlkevLKKCKFVTTMGFRMMLTEPIILSMGLYN 316
Cdd:COG0477   168 RWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLAAL--------ALALLALLLLLLLLLLALLALLLAGAAL 239

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1246742890 317 FYAYGISYFFLTAIWPVFYDTYKMSEMGASCTYLSGFVASTLLFL 361
Cdd:COG0477   240 LLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLLL 284
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
77-257 1.49e-15

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 77.99  E-value: 1.49e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890  77 WAKRWSIVFMFCLMQIYVIWTSNGFGSIEYSVMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFV 156
Cdd:COG2271     5 SRYRWRILALLFLAYFLNYLDRSNLSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLL 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 157 YTVFNISCALPRNIVQMIISHFIIGVAGSTALTNVAGGIPDLFPEDTAGVPMSLFVWACAGGAIGAPMATGVdINAKYGW 236
Cdd:COG2271    85 WGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLLGW-LLAAFGW 163

                         170       180
                  ....*....|....*....|.
gi 1246742890 237 RWLYYINIIVGGFFLIVILII 257
Cdd:COG2271   164 RAAFLILGLPGLLLALLRFWL 184
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 87-475 1.91e-15

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 77.85  E-value: 1.91e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890  87 FCLMQIYVIWTSNGFGSIEYSVMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCAL 166
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 167 PRNIVQMIISHFIIGVAGSTALTNVAGGIPDLFPEDTAGVPMSLF-VWACAGGAIGAPMATGVDINAKYGWRWLYYINII 245
Cdd:cd06174    81 APSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLqAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAA 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 246 VGGFFLIVILIIPETLPIKVITRYENAKgrivEGIPKNNLKEVLKKckfvttmgfrmmltePIILSMGLYNFyAYGISYF 325
Cdd:cd06174   161 LALLAAILLLLVVPDPPESARAKNEEAS----SKSVLKLLKRVLKN---------------PGLWLLLLAIF-LVNLAYY 220

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 326 FLTAIWPVFYDTYKMSEMGASCTYLSGFVASTLLFLyqPIQDWIFRRDKAKnngvarpeaRFTSALFITLLFPAGMFLFA 405
Cdd:cd06174   221 SFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGS--LLLGLLSDRLIGR---------KPLLLIGLLLMALGLALLLL 289

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 406 FTCHPPFPWMSPIVGNSMVTVANGHNWMCILNYLTDSYPLLSGSAVAAFTLPSFIGATVFAHVSQIMFNN 475
Cdd:cd06174   290 APSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIGPLLAGFLLAATFGL 359
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 110-474 3.82e-14

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 74.15  E-value: 3.82e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 110 AQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGSTALT 189
Cdd:cd17320    27 RDLGASASAVQLTLSAYLLGFALGQLLYGPLSDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAGSV 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 190 NVAGGIPDLFPEDTAGVPMS-LFVWACAGGAIgAPMATGVdINAKYGWRWLYYINIIVGGF-FLIVILIIPETLPIKVIT 267
Cdd:cd17320   107 VARAIVRDLYSGAELAKIFSlLMMILAIAPAL-APLLGGL-LLLFFGWRAIFVFLALLGLLlLLLVLLFLPETLPEEKRK 184

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 268 RYENAKGRIvegipknnlkevlkkckfvttmgFRMMLTEPIILSMGLYNFYAYGISYFFLTAiWPVFY-DTYKMSEMGAS 346
Cdd:cd17320   185 PLLSSLLRA-----------------------YKRVLKNRRFLGYALALGLSFAGLFAYLAA-APFIYiEQLGLSPAQFG 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 347 CTYLSGFVASTLLFLyqpIQDWIFRRDKaknngvarPEARFTSALFITLLFPAGMFLFAFTCHPPFPWMSPIvgnsMVTV 426
Cdd:cd17320   241 LLFALNAIALILGSL---LNGRLVRRFG--------PRRLLRLGLLLLLAAALVLLLAALLGGLSLWPLVAP----LFLI 305

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1246742890 427 ANGHNWMC--ILNYLTDSYPLLSGSAVAAFTLPSFIGATVFAHVSQIMFN 474
Cdd:cd17320   306 FFGFGLIFpnATSLALEPFPHVAGTASALLGFLQFLIGALAGALVGLLPN 355
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 107-341 2.02e-12

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 68.95  E-value: 2.02e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 107 SVMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGST 186
Cdd:TIGR00710  30 EIAADLSTPASIVQMTLTLYLLGFAAGQLLWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQAFGASA 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 187 ALTNVAGGIPDLFPEDTAGVPMSLFVWACAGGAIGAPMaTGVDINAKYGWRWLYYInIIVGGFFLI--VILIIPETLPik 264
Cdd:TIGR00710 110 GSVISQALVRDIYPGEELSRIYSILMPVLALAPAVAPL-LGGYILVWLSWHAIFAF-LSLAGILLSalIFFILPETLP-- 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 265 vitrYENakgRIVEGIPKNNLKEVLKKCKFVTTM--------GFRMMLTEPIILSMGLYNFYAYGISYFFLTAIWPVFYD 336
Cdd:TIGR00710 186 ----YEA---RIQISTYFETFLLLLKSKMFWGYAliygasfgGFFAFFSGAPFVYIDIMGVSPSVFGLLFALNIIAMIFG 258


                  ....*
gi 1246742890 337 TYKMS 341
Cdd:TIGR00710 259 GFLNG 263
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
110-262 3.58e-12

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 68.02  E-value: 3.58e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 110 AQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGSTALT 189
Cdd:PRK11102   19 ADFGVSAGSVQMTLSAYILGFAIGQLFYGPMADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAAAAASV 98

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1246742890 190 NVAGGIPDLFPEDTAGVPMSLFVWACAGGAIGAPMATGVdINAKYGWRWLYYINIIVGGF-FLIVILIIPETLP 262
Cdd:PRK11102   99 VINALMRDMFPKEEFSRMMSFVTLVMTIAPLLAPIIGGW-LLVWFSWHAIFWVLALAAILaAALVFFFIPETLP 171
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 85-256 4.32e-12

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 68.42  E-value: 4.32e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890  85 FMFCLMQIYVIWTSNGFGSIEYSVMAQFNVSAQVATLCLSMNILGSGLGPMFlGPLSDIGGRKPVYFCSIFVYTVFNISC 164
Cdd:cd06179     1 AALCLAYFAQLFGVTLPAAVLPFIVADLGPSSNSTWISTAWSLAQAVLGPIV-GRLSDLFGRRWFFIGGNLLGVVGSIVA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 165 ALPRNIVQMIISHFIIGVAGSTALtNVAGGIPDLFPEDTAGVPMSLFVWACA-GGAIGAPMATGVDINAKYGWRWLYYIN 243
Cdd:cd06179    80 GTAKSVNMLIGGQALIGIGAGTQG-LGAAVASELVPNKYRGLVQGVVNLVASpGSALGPLIAGALVEANAAGWRWIFYIN 158

                         170
                  ....*....|...
gi 1246742890 244 IIVGGFFLIVILI 256
Cdd:cd06179   159 AIFNALALILLFF 171
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 100-262 1.01e-10

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 63.34  E-value: 1.01e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 100 GFGSIEYSVM-------AQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQ 172
Cdd:cd17324    10 AIGTTEYVIQgllpdiaRDFGVSVAQAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFAL 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 173 MIISHFIIGVAGSTALTNVAGGIPDLFPEDTAGVPMSLFVWACA-GGAIGAPMATGvdINAKYGWRWLYYiniIVGGFFL 251
Cdd:cd17324    90 LLLARALAGLAHGGFWAIAAAYAADLVPPEKRGRAIGLVFSGLTlGLVLGRPLGGL--LGQLLGWRAAFL---AIAVLAL 164

                         170
                  ....*....|.
gi 1246742890 252 IVILIIPETLP 262
Cdd:cd17324   165 LAALLLWRLLP 175
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 102-257 3.23e-10

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 61.83  E-value: 3.23e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 102 GSIEYSVMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIG 181
Cdd:cd17365    19 GFVAPALAQDWGLSPAQLGPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAFAQSVLQLALLRFLTG 98

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1246742890 182 VAGSTALTNVAGGIPDLFPEDTAGVPMSL-FVWACAGGAIGAPMATGVdINAkYGWRWLYYIniivGGFFLIVILII 257
Cdd:cd17365    99 LGLGAAMPNAITLVSEYAPARRRSLAVTLmFCGYPLGAALGGFLAAAL-IPA-FGWRSVFLL----GGVPPLILLPL 169
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 128-327 3.26e-10

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 61.82  E-value: 3.26e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 128 LGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGSTALTNVAGGIPDLFPEDTAGVP 207
Cdd:cd17325    42 LAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADIAPPEERGRA 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 208 MSLFVWACAGGAIGAPMATGVdINAKYGWRWLYYINIIVGGF-FLIVILIIPETLPIKVITRYENAKGRIVEGIPKNNlK 286
Cdd:cd17325   122 MGIFSSAIGLGFLIGPLLGGL-LADALGYRAPFLVCAALALLaLVLALLLLPEPRPPPNKRAVSAARLRSGLRLLLRD-R 199

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|...
gi 1246742890 287 EVLKKCKFVTTMGFRMMLTEPI--ILSMGLYNFYAYGISYFFL 327
Cdd:cd17325   200 RLLALFLAIFVLAFAFGALEPFlpLYAAELGGLSPAQIGLLFG 242
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 136-257 9.24e-10

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 60.27  E-value: 9.24e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 136 FLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFI--IGVAGSTALTNVAGGipDLFPEDTAGVPMSLFVW 213
Cdd:cd17502    49 IYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIqgIGGGGLMSLAFIIIA--DLVPPRERGKYQGYIGA 126

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1246742890 214 ACAGGAIGAPMATGVdINAKYGWRWLYYINIIVGGFFLIVILII 257
Cdd:cd17502   127 VFGIASVAGPLIGGA-FTDHLSWRWCFYINLPIGGLALALLRTI 169
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
78-257 4.27e-09

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 58.35  E-value: 4.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890  78 AKRWSIVFM--FCLMQIYVIWTSngFGSIEYSVMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIF 155
Cdd:COG2223     1 SGRWRVLLLatLAFFLAFGVWYL--WSVLAPPLAEEFGLSAAQLGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 156 VYTVFNISCALPRNIVQMIISHFIIGVAGSTALTNVAGGIPDLFPEDTAGVPMSLFV-WACAGGAIGAPMATGVdINAkY 234
Cdd:COG2223    79 LLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAgGGNLGAAVAAFLAPLL-IAA-F 156

                         170       180
                  ....*....|....*....|...
gi 1246742890 235 GWRWLYyinIIVGGFFLIVILII 257
Cdd:COG2223   157 GWRNAF---LILGILLLVVAVLA 176
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 115-263 8.36e-09

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 57.58  E-value: 8.36e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 115 SAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGSTALTNVAGG 194
Cdd:cd17315    32 STSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVGLASVLVPLY 111

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 195 IPDLFPEDTAGVPMSLFVWACAGGAIGAP-MATGVDINAKYGWRWLYYINIIVGGFFLIVILIIPETLPI 263
Cdd:cd17315   112 ISEIAPAKIRGALGTLNQLMITFGILLAYlLGLALSLSPPGWWRLMFALAAVPALLQLLLMFFLPESRAL 181
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 107-357 1.31e-08

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 56.98  E-value: 1.31e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 107 SVMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFI--IGVAG 184
Cdd:TIGR00895  42 AISAEWGLDPVQLGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLagLGLGG 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 185 STALTN--VAGGIPDLFPEDTAGVPMSLF-VWACAGGAIGAPMAtgvdinAKYGWRWLYYINIIVGGFFLIVILI-IPET 260
Cdd:TIGR00895 122 LMPNLNalVSEYAPKRFRGTAVGLMFCGYpIGAAVGGFLAGWLI------PVFGWRSLFYVGGIAPLLLLLLLMRfLPES 195

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 261 LPIKVITRYENAK---GRIVEGIPKNNLKEVLKKCKFVTTM-GFRMMLTEPIIL--SMGLYNFYAYGISYFFLTAIW-PV 333
Cdd:TIGR00895 196 IDFLVSKRPETVRrivNAIAPQMQAEAQSALPEQKSTQGTKrSVFKALFQGKTAriTVLLWLLYFMLLVGVYFLTNWlPK 275

                         250       260
                  ....*....|....*....|....
gi 1246742890 334 FydtykMSEMGASCTYLSGFVAST 357
Cdd:TIGR00895 276 L-----MVELGFSLSLAATGGALF 294
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 110-260 1.38e-08

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 56.81  E-value: 1.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 110 AQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGSTALT 189
Cdd:cd17359    29 TDFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASA 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 190 NVAGGIPDLFPEDTAGVPMSLFVWACAGG---------AIGAPMATGVDINAkyGWRWLYYINIIVGGFFLIVILIIPET 260
Cdd:cd17359   109 LVPMYIAEVAPAEIRGRLVSLNQLMIVFGqllayivnyLIANAGGADWLGAE--GWRWMLGLEAIPAILFLLGMLFIPES 186
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 107-258 1.41e-08

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 56.80  E-value: 1.41e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 107 SVMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGST 186
Cdd:cd17321    21 TIARDLGASPSQLQWVVNAYLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAA 100

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1246742890 187 ALTNVAGGIPDLFPEDTAGVPMSLFVWACAGGAIGAPMATGVdINAKYGWRWLYYINIIVGgffLIVILIIP 258
Cdd:cd17321   101 IMPASLALIAATFPGERRGRALGLWGAVVGIGAALGPLLGGL-LLELFGWRWIFLINVPIG---LVALLLAR 168
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 84-257 3.72e-08

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 55.27  E-value: 3.72e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890  84 VFMFCLMqiyVIWTSNGFGSIE--YSVMAQ--FNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTV 159
Cdd:cd17325   201 LLALFLA---IFVLAFAFGALEpfLPLYAAelGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGLLLSAV 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 160 FNISCALPRNIVQMIISHFIIGVAGSTALTNVAGGIPDLFPEDTAGVPMSLFVWACAGGAIGAPMATGVdINAKYGWRWL 239
Cdd:cd17325   278 ALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLGPLLGGF-LYDAFGFATP 356

                         170
                  ....*....|....*...
gi 1246742890 240 YYINIIVGGFFLIVILII 257
Cdd:cd17325   357 FLAAAALLLLAAVLFLLL 374
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 135-259 5.52e-08

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 54.93  E-value: 5.52e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 135 MFLGP----LSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVaGSTALTNVAGG-IPDLFPEDTAGVPMS 209
Cdd:cd17328    48 MVLSPifgyLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLLFRALVGI-GEASYSPIAPTiIADLFPKEKRTRALG 126

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1246742890 210 LFVWACAGGAIGAPMATGVDINAKYGWRWLYYINIIVGGFFLIVILIIPE 259
Cdd:cd17328   127 VFYFAIPLGSGLGYVVGGLVAQATGGWRWAFRVTGVLGVLLAILLLLFVR 176
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 108-258 1.08e-07

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 54.12  E-value: 1.08e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 108 VMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGstA 187
Cdd:cd17504    22 IQREFGTSAAAVSWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGG--A 99

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1246742890 188 LTNVAGGI-PDLFPEDTAGVPMSLF-VWACAGGAIGAPMAtGVdINAKYGWRWLYYINIIVGGFFLIVILIIP 258
Cdd:cd17504   100 VFPLAFALvREEFPPERVPVAQGILsATFGIGAGIGLPLG-GW-IVQHLGWRWIFWTAAPVAVLLAALVPLID 170
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 140-258 2.33e-07

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 52.96  E-value: 2.33e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 140 LSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGSTALTNVAGGIPDLFPEDTAGVPMSLFVWACAGGA 219
Cdd:cd17503    54 LADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVLIPLAQTILLRIYPPEKRGAAMGLVGLVILLAP 133

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1246742890 220 IGAPMATGVdINAKYGWRWLYYINIIVGgffLIVILIIP 258
Cdd:cd17503   134 AIGPTLGGW-LTDNLSWRWIFYINLPIG---ILALLLAP 168
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 124-260 3.19e-07

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 52.66  E-value: 3.19e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 124 SMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGSTALTNVAGGIPDLFPEDT 203
Cdd:cd17360    42 SSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRI 121

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1246742890 204 AGVPMSLFVWACAGGAIGAPMATGVDINAKYGWRWLYYINIIVGGFFLIVILIIPET 260
Cdd:cd17360   122 RGRLVTINVLFITGGQFVAYVINGAFSYLPGGWRWMLGLAAVPAVLQFIGLLFLPES 178
efflux_EmrB TIGR00711
drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a ...
 108-257 3.49e-07

drug resistance transporter, EmrB/QacA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 14 potential membrane-spanning regions. Members with known activities include EmrB (multiple drug resistance efflux pump) in E. coli, FarB (antibacterial fatty acid resistance) in Neisseria gonorrhoeae, TcmA (tetracenomycin C resistance) in Streptomyces glaucescens, etc. In most cases, the efflux pump is described as having a second component encoded in the same operon, such as EmrA of E. coli. [Cellular processes, Toxin production and resistance, Transport and binding proteins, Other]


Pssm-ID: 129794 [Multi-domain]  Cd Length: 485  Bit Score: 52.77  E-value: 3.49e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 108 VMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGSTA 187
Cdd:TIGR00711  28 IAGDLGSSLSQVQWVITSYMLANAISIPLTGWLAKRFGTRRLFLISTFAFTLGSLLCGVAPNLELMIIFRVIQGFGGGPL 107

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 188 LTNVAGGIPDLFPEDTAGVPMSLFVWACAGGAIGAPMATGVdINAKYGWRWLYYINIIVGGFFLIVILII 257
Cdd:TIGR00711 108 IPLSFSTLLNIYPPEKRGRAMAIWGLTVLVAPALGPTLGGW-IIENYHWRWIFLINVPIGIIVVVVAFFI 176
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 80-257 3.88e-07

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 52.19  E-value: 3.88e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890  80 RWSIVFMFCLMQI--YVIWTSNGFgsIEYSVMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVY 157
Cdd:cd17319     1 RWRIIPLLFLAYVinYLDRVNISV--AAPTIMKDLGLSPTQYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 158 TVFNISCALPRNIVQMIISHFIIGVAGSTALTNVAGGIPDLFPEDTAGVPMSLFVWACA-GGAIGAPMATGvdINAKYGW 236
Cdd:cd17319    79 SLFTALTGFATSLTSLYVLRFLLGVAEAGFFPGAIKALAEWFPARERGRATGLFNSGAPlGAAIGPPLSGW--LLLLFGW 156

                         170       180
                  ....*....|....*....|.
gi 1246742890 237 RWLYYINIIVGGFFLIVILII 257
Cdd:cd17319   157 RWAFIIEGLLGLLLAVLWWFY 177
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 112-257 2.06e-06

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 49.91  E-value: 2.06e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 112 FNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGSTALTNV 191
Cdd:cd17316    31 LGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGGEYPGA 110

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1246742890 192 AGGIPDLFPEDTAGvpmSLFVWACAGGAIGAPMATGV------DINAKYGWRWLYYIniivGGFFLIVILII 257
Cdd:cd17316   111 STYVAEFAPSKRRG---FALGLLQSGWALGALLAALVasllipLLSGDWGWRILFLI----GALPALLALLL 175
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 92-264 2.90e-06

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 49.53  E-value: 2.90e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890  92 IYVIWTSNGFGSIEYSVMAQFNV---------SAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNI 162
Cdd:cd17329     1 LWVLLIGSFLNRLGFFMVWPFMAiylhqqlglSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 163 SCALPRNIVQMIISHFIIGVAGSTALTNVAGGIPDLFPEDTAGVPMSLFVWAC-AGGAIGAPMATGVdinAKYGWRWLYY 241
Cdd:cd17329    81 LLGFAHSPWLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAFSLLYWAInLGVAIGPLLGGLL---LLYSFRLLFL 157

                         170       180
                  ....*....|....*....|....
gi 1246742890 242 INIIV-GGFFLIVILIIPETLPIK 264
Cdd:cd17329   158 AAAVLfLLAALVLLFLLPETRPKR 181
Sugar_tr pfam00083
Sugar (and other) transporter;
89-291 4.11e-06

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 49.19  E-value: 4.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890  89 LMQIYVIWTSNGFGS-IEYSVMAQFNVS-------AQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVF 160
Cdd:pfam00083  10 FLFGYDTGVIGAFLTlIDFFKNFGLSKSvsslaalSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIG 89

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 161 NISCALP---RNIVQMIISHFIIGVAGSTALTNVAGGIPDLFPEDTAGVPMSLFVWACAGGAIGAPMAT--GVDINAKYG 235
Cdd:pfam00083  90 AVLQGAAkgkWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAYIFGlgLNKTSNSDG 169

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1246742890 236 WRWLYYINIIVGGFFLIVILIIPETlpikviTRYENAKGRIVEGipknnlKEVLKK 291
Cdd:pfam00083 170 WRIPLGLQLVPALLLIIGLLFLPES------PRWLVEKGRLEEA------REVLAK 213
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 137-273 1.13e-05

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 47.60  E-value: 1.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 137 LGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIigvAGSTALTNVAGG-IPDLFPEDTAGVPMSlFVWAC 215
Cdd:cd17472    52 FGLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRAL---QGSGAISSVVMAlLADLTREENRTKAMA-LIGAS 127

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1246742890 216 AGGAIGAPMATGVDINAKYGWRWLYYINIIVGGF-FLIVILIIPETLPIKVITRYENAK 273
Cdd:cd17472   128 IGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVsLLILLFFVPDPPKIVQISEKEKKK 186
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 96-258 1.13e-05

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 47.58  E-value: 1.13e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890  96 WTSNGFGSIEYSVMAQFNV---SAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQ 172
Cdd:cd17317     1 GWEFDYSVSESTIVTEWDLvcdRDWLVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYEL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 173 MIISHFIIGVAGSTALTnvAGGIpdLFPEDTAGVPMSL-FVWACAGGAIGAPMATGVDINAKYgWRWLYYINIIVGGFFL 251
Cdd:cd17317    81 FLVLRFLVGVTSAGIFT--VGFV--LGMEIVGPKYRSFvGILFGLFWALGYMLLALLAYLIRD-WRWLQLAISLPGLLFL 155


                  ....*..
gi 1246742890 252 IVILIIP 258
Cdd:cd17317   156 LLLWWLP 162
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
81-258 1.44e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 47.17  E-value: 1.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890  81 WSIVFMFCLMqiYVIWTSNGFGSIEYsVMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSD--IGGRKPVYFCSIFVYT 158
Cdd:COG2271   183 WLLALAYFLV--YFALYGFLTWLPTY-LVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDrlGRRRKLVLAIGLLLAA 259

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 159 VFNISCALPRNIVQMIISHFIIGVAGSTALTNVAGGIPDLFPEDTAGVPMSLFVWACAGGAIGAPMATGVdINAKYGWRW 238
Cdd:COG2271   260 LALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGFLGGALGPLLVGY-LLDATGYQA 338

                         170       180
                  ....*....|....*....|
gi 1246742890 239 LYYINIIVGGFFLIVILIIP 258
Cdd:COG2271   339 AFLLLAALALLAALLALLLL 358
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 131-335 2.64e-05

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 46.60  E-value: 2.64e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 131 GLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGSTALTNVAGGIPDLFPEDTAGVPMSl 210
Cdd:TIGR00881  44 GISKFVMGSVSDRSNPRVFLPIGLILCAIVNLFFGFSTSLWVMAALWALNGIFQGMGWPPCGRTVTKWFSRSERGTWVS- 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 211 fVWACA---GGAIGAPMAtGVDINAKYGWRWLYY----INIIVGgfFLIVILIIPETLPIKvITRYENAKGRIVEGIPKN 283
Cdd:TIGR00881 123 -FWNCShnvGGGLLPPLV-LFGIAELYSWHWVFIvpgiIAIIVS--LICFLLLRDSPQSCG-LPPAEEMPNEEPDGDAEK 197

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1246742890 284 NLKEVLKKckfvtTMGFRMMLTEPIILSMGLYNFYAYGISYFFLTaiWPVFY 335
Cdd:TIGR00881 198 KEEELTKK-----QIFLQYVLLNKVLWYISLGYVFVYVVRTGILD--WSPLY 242
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 107-260 3.53e-05

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 46.14  E-value: 3.53e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 107 SVMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFI--IGVAG 184
Cdd:cd17371    24 ALIAEFGLDEAEAGLLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGFAQNYWQLLILRALagLGFGG 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 185 STALTN--VAGGIPDLFPEDTAGVPMSlfvwacaGGAIGAPMATGV------DINAKYGWRWLYYINIIVGGFFLIVILI 256
Cdd:cd17371   104 EWAAGAalMAEYVPARHRGKALGYVQS-------GWAVGWLLATLLaallfpLLPPEIAWRVLFLLGALPALLVLFIRRF 176


                  ....
gi 1246742890 257 IPET 260
Cdd:cd17371   177 VKEP 180
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 136-265 4.28e-05

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 45.66  E-value: 4.28e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 136 FLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGSTALTNVAGGIPDLFPEDTAGVPMSLFVWAC 215
Cdd:cd17489    50 FAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAATLVADIIPPSRRGEGIGYYGLAT 129

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|
gi 1246742890 216 AGGAIGAPMAtGVDINAKYGWRWLYYINIIVGGFFLIVILIIPETLPIKV 265
Cdd:cd17489   130 TLAMALGPAL-GLFLYQHLGFAVLFIVAAVLALLALLLVFLVKDPPPVAA 178
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 115-260 7.36e-05

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 45.32  E-value: 7.36e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 115 SAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTV-FNISCALPRNIVQMIISHFI--IGVAGSTALtnV 191
Cdd:cd17356    43 SSSRQGLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIgAIIQVAAIGKWYQLIVGRIIagLGVGFASVL--V 120

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1246742890 192 AGGIPDLFPEDTAGVPMSLFVWACAGGA-IGAPMATGVDINAKYG-WRWLYYINIIVGGFFLIVILIIPET 260
Cdd:cd17356   121 PVYQSEVAPKHIRGTLVSLYQLAITIGIlVAYCINYGTHKLDGSAqWRIPLGLQIVWGLLLLIGMFFLPES 191
MFS_FEN2_like cd17327
Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; ...
 151-331 2.06e-04

Pantothenate transporter FEN2 and similar transporters of the Major Facilitator Superfamily; This family is composed of Saccharomyces cerevisiae pantothenate transporter FEN2 (or fenpropimorph resistance protein 2) and similar proteins from fungi and bacteria including fungal vitamin H transporter, allantoate permease, and high-affinity nicotinic acid transporter, as well as Pseudomonas putida phthalate transporter and nicotinate degradation protein T (nicT). These proteins are involved in the uptake into the cell of specific substrates such as pathothenate, biotin, allantoate, and nicotinic acid, among others. The FEN2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340885 [Multi-domain]  Cd Length: 406  Bit Score: 43.78  E-value: 2.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 151 FCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGSTALTNVAGGIPDLFPEDTAGVPMSLFV-WACAGGAIGAPMATGV- 228
Cdd:cd17327    75 SVFIVLWGLLTLLTAAVKNFGGLIALRFFLGLFESGVFPGFILYLGMWYKREEQAKRIAFFYaAAGLGSIFGGLLAYGVf 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 229 ---DINAKYGWRWLYYINIIVGGFFLIVILIIPETLPIKVITRYENAKGRIVEGIPKNNLKEVLKKCKFVTtmgFRMMLT 305
Cdd:cd17327   155 kilGVGGLAGWRWLFIIEGLITIIIGLVIFFWLPDNPSKAWFLTEEEKELAVERLRANQTGKGDQKFKWKQ---IKEAFK 231

                         170       180
                  ....*....|....*....|....*....
gi 1246742890 306 EPIILSMGLYNFYAY---GISYFFLTAIW 331
Cdd:cd17327   232 DPRTWLLFLFFFCSQitnNGISNFLPLIL 260
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
79-257 2.15e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 43.74  E-value: 2.15e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890  79 KRWSIVFMFCLMQIYVIWTSNGFgsIEYSVMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYT 158
Cdd:COG2211   228 RPFLLLLLAYLLFFLALALVAAL--LLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAA 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 159 VFNISCAL--PRNIVQMIISHFIIGVAGSTALTNVAGGIPDLFPED-------TAGVPMSLFVWA-CAGGAIGAPMATGV 228
Cdd:COG2211   306 LGLLLLFFlgPGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDewktgrrREGLYFGIFTFAiKLGQALAGALAGLL 385

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|.
gi 1246742890 229 ------------DINAKYGWRWLYyinIIVGGFFLIVILII 257
Cdd:COG2211   386 lalfgyvagaaqSPSALTGIRLLF---FLLPAVLLLLAALL 423
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 96-260 2.51e-04

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 43.72  E-value: 2.51e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890  96 WTSNGFGSIEYSVMAQFNVS-AQVATLClSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMI 174
Cdd:cd17358    20 WSSPALPSLMSDNSLSLPLTvAQFSWFG-SLLTLGALIGALLSGKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLY 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 175 ISHFIIGVAG------------STALTNVAGgipdlfpedTAGVPMSLFVwaCAGGAIGAPMATGVDinakygWRWLYYI 242
Cdd:cd17358    99 LGRFLAGFGGgaasvvvpvyiaEIAPKNVRG---------ALGSLNQLLV--NIGILLGYVLGSFLP------WRTLALI 161

                         170
                  ....*....|....*...
gi 1246742890 243 NIIVGGFFLIVILIIPET 260
Cdd:cd17358   162 GAIPPVVFLILLFFIPES 179
MFS_YcxA_like cd17355
MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of ...
 81-257 2.64e-04

MFS-type transporter YcxA and similar proteins of the Major Facilitator Superfamily of transporters; This group is composed of uncharacterized bacterial MFS-type transporters including Bacillus subtilis YcxA and YbfB. YcxA has been shown to facilitate the export of surfactin in B. subtilis. The YcxA-like group belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340913 [Multi-domain]  Cd Length: 386  Bit Score: 43.41  E-value: 2.64e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890  81 WSIVFMFCLMQIYVIWTSNGFGSIEYSVMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVF 160
Cdd:cd17355     2 WVVLAVTFLILILSWGIRYYFGVFIIPIIAEFGWSRAVISLAFTVGLLAFGLAQPFVGRLLDRFGPRRVMLLGLLLLAAG 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 161 NISCALPRNIVQMIISHFIIGVAGSTALTNVAG-GIPDLFPEDTAGVPMS-LFVWACAGGAIGAPMatGVDINAKYGWRW 238
Cdd:cd17355    82 LVLLALATSLWQLYLLWGLLGGGGAGTLAAVAFaTVAAWWFERRRGLALGiLTAGGGLGSLVFLPL--GAALIEAFGWRT 159

                         170
                  ....*....|....*....
gi 1246742890 239 LYyinIIVGGFFLIVILII 257
Cdd:cd17355   160 AL---LVLALLALLVLVPV 175
PRK03893 PRK03893
putative sialic acid transporter; Provisional
 132-245 2.73e-04

putative sialic acid transporter; Provisional


Pssm-ID: 179668 [Multi-domain]  Cd Length: 496  Bit Score: 43.53  E-value: 2.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 132 LGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVA-----GSTAlTNVAGGIPDLFPEDTAGV 206
Cdd:PRK03893   70 FGGLLLGAMGDRYGRRLAMVISIVLFSVGTLACGFAPGYWTLFIARLVIGMGmageyGSSA-TYVIESWPKHLRNKASGF 148

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1246742890 207 PMSLFvwacaggAIGAPMATGVD--INAKYGWRWLYYINII 245
Cdd:PRK03893  149 LISGF-------SIGAVVAAQVYslVVPVWGWRALFFIGIL 182
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 121-278 3.12e-04

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 43.48  E-value: 3.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 121 LCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVY---TVFNISCALPRNIVQMIISHFI--IGVAGSTALTNVAggI 195
Cdd:TIGR00879  75 LVVSIFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFvigAILMGLAAFALSVEMLIVGRVLlgIGVGIASALVPMY--L 152

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 196 PDLFPEDTAGVPMSLFVWACAggaIGAPMATGVDINAKY-----GWRWLYYINIIVGGFFLIVILIIPETLpikvitRYE 270
Cdd:TIGR00879 153 SEIAPKALRGALTSLYQLAIT---FGILVAYGFGSGKVSlnntlGWRIPLGLQLIPAGLLFLGLFFLPESP------RWL 223


                  ....*...
gi 1246742890 271 NAKGRIVE 278
Cdd:TIGR00879 224 VGKGRVEE 231
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 107-259 4.43e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 42.56  E-value: 4.43e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 107 SVMAQFNVS-AQVATLCLSMNILGSGLGPmFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGS 185
Cdd:cd17474    24 AIAEALGASpAQVGLLITAFTLPAAVLMP-VAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIGAA 102

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1246742890 186 TALTNVAGGIPDLFPEDTAGVPMSLFVWACAGGAIGAPMATGvdINAKYGWRWLYYINIIVGGFFLIVILIIPE 259
Cdd:cd17474   103 GLGPLALTLIGDLFEGGERAKAMGLYEAALGLGIAVGPLLGG--LLAAISWRYPFFLLAALIPVAFLAILFLLP 174
PRK15402 PRK15402
MdfA family multidrug efflux MFS transporter;
108-183 4.56e-04

MdfA family multidrug efflux MFS transporter;


Pssm-ID: 185300 [Multi-domain]  Cd Length: 406  Bit Score: 42.62  E-value: 4.56e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246742890 108 VMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVA 183
Cdd:PRK15402   39 VVEDFNAGAEWVPTSMTAYLAGGMFLQWLLGPLSDRIGRRPVMLAGVAFFILTCLAILLAQSIEQFTLLRFLQGIG 114
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 80-255 4.73e-04

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 42.59  E-value: 4.73e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890  80 RWSIVFMFCLMQIYVIwTSNGFGSIEYSVMAQ-FNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYT 158
Cdd:cd17316   176 RRRTLLLILLWFFISF-GYYGLTTFLPTYLQTvLGLSPATSSLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSG 254

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 159 VFNI--SCALPRNIVQMIISHFIIGVAGSTALTNVAGGIPDLFPEDTAGVPMSLFVWACAGGAIGAPMATGVDINAKYGW 236
Cdd:cd17316   255 ILALplFYLLSGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNLGRLGGGGAPPLIALLLASTGGT 334

                         170
                  ....*....|....*....
gi 1246742890 237 RWLYYINIIVGGFFLIVIL 255
Cdd:cd17316   335 GVPALILALLAIVALIVAL 353
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 111-257 1.27e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 41.15  E-value: 1.27e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 111 QFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGSTALTN 190
Cdd:cd17333    25 AFNLNVADVSVIFSSQNAGYLIGSLLAGFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGILDTG 104

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1246742890 191 VAGGIPDLFPEDTAgvPMSLFVWACAG-GAIGAPMATGVDINAKYGWRWLYYiniIVGGFFLIVILII 257
Cdd:cd17333   105 ANTFVGALFEESSA--TRLNVLHGFFGlGALIGPLIATSLLTSELSWSWAYL---IIGLIYLLLAILI 167
PRK12307 PRK12307
MFS transporter;
104-245 1.34e-03

MFS transporter;


Pssm-ID: 237051 [Multi-domain]  Cd Length: 426  Bit Score: 41.07  E-value: 1.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 104 IEYSVMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVA 183
Cdd:PRK12307   40 IMYLIKADLGLTDMEGAFLATAAFIGRPFGGALFGLLADKFGRKPLMMWSIVAYSVGTGLSGLASGVIMLTLSRFIVGMG 119

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1246742890 184 GSTALTNVAGGIPDLFPEDTAGVPMSLFVwacAGGAIGAPMATGV--DINAKYGWRWLYYINII 245
Cdd:PRK12307  120 MAGEYACASTYAVESWPKHLKSKASAFLV---SGFGIGNIIAAYFmpSFAEAYGWRAAFFVGLL 180
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 132-258 1.36e-03

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 40.92  E-value: 1.36e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 132 LGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVA-GSTALTNVAggipdLFPEDtagvpMSL 210
Cdd:cd17377    54 IGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNALAPSYEFFAVSRFLVGVMnGGMSLVAFV-----LLNEC-----VGK 123

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1246742890 211 FVWACAGGAIGAPMATGVDINAKYG-----WRWLYYINIIVGGFFLIVILIIP 258
Cdd:cd17377   124 SYWALAGSLGGLFFAVGIAQYALLGyfirsWRTLAVVVNLQGTLVFLLSLFIP 176
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 123-260 2.20e-03

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 40.71  E-value: 2.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 123 LSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTV---FNISCALPRNIVQMIISHFIIGVAGSTALTNVAGGIPDLF 199
Cdd:cd17357    55 VSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVsslLMFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEIS 134

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1246742890 200 PEDTAGvPMSLF--VWACAGGAIGAPMATGVDINAKYGWRWLYYINIIVGGFFLIVILIIPET 260
Cdd:cd17357   135 PSELRG-ALGSLtqIGVTLGILLGQVFGLPSVLGTETLWPYLLFFPGIPALLQLAALPFFPES 196
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 132-318 2.21e-03

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 40.77  E-value: 2.21e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 132 LGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGstaltnvAGGIPDLFPEDTAGVPMSLF 211
Cdd:TIGR00898 142 LGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMGI-------GGIWVQAVVLNTEFLPKKQR 214

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 212 VWA----CAGGAIGAPMATGVDInAKYGWRWLYYINIIVGGFFLIVILIIPETlpikviTRYENAKGRIVEGIpkNNLKE 287
Cdd:TIGR00898 215 AIVgtliQVFFSLGLVLLPLVAY-FIPDWRWLQLAVSLPTFLFFLLSWFVPES------PRWLISQGRIEEAL--KILQR 285

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1246742890 288 VLKKCKFVTTMGFRMM-LTEPIILSMGLYNFY 318
Cdd:TIGR00898 286 IAKINGKKLPAEVLSLsLEKDLSSSKKQYSFL 317
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 75-257 3.34e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.91  E-value: 3.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890  75 WHWAKRWSIVFMFCLMQIYVIWTSNGFGSIEYSVMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSI 154
Cdd:cd06173   202 RYLRRSPLLRLLLLALALFALLGGALTVLLPLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGA 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 155 FVYTVFNISCALPRNIVQMIISHFIIGVAGSTALTNVAGGIPDLFPEDTAGVPMSLFVWACAGGAIGAPMATGVdINAKY 234
Cdd:cd06173   282 LLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDELRGRVFSVYNALNSGAMPLGALLAGL-LADAL 360

                         170       180
                  ....*....|....*....|...
gi 1246742890 235 GWRWLYyiniIVGGFFLIVILII 257
Cdd:cd06173   361 GLSAVF----LLAGALLLLAALL 379
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 136-186 5.23e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 39.10  E-value: 5.23e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1246742890 136 FLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGST 186
Cdd:cd17330    53 LWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTGGN 103
PRK15403 PRK15403
multidrug efflux MFS transporter MdtM;
108-261 6.25e-03

multidrug efflux MFS transporter MdtM;


Pssm-ID: 237958 [Multi-domain]  Cd Length: 413  Bit Score: 39.04  E-value: 6.25e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 108 VMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGSTA 187
Cdd:PRK15403   42 VVRDFNADVSLAPASVSLYLAGGMALQWLLGPLSDRIGRRPVLITGALIFTLACAATLFTTSMTQFLIARFIQGTSICFI 121

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246742890 188 LTNVAGGIPDLFPEDTAGVPMSLFVWACAGGAIGAPMAtGVDINAKYGWRWLYYInIIVGGF--FLIVILIIPETL 261
Cdd:PRK15403  122 ATVGYVTVQEAFGQTKGIKLMAIITSIVLVAPIIGPLS-GAALMHFVHWKVLFAI-IAVMGLiaFVGLLLAMPETV 195
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
107-257 6.48e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 39.07  E-value: 6.48e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 107 SVMAQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGST 186
Cdd:COG0738    33 ALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGL 112

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1246742890 187 ALTNVAGGIPDLFPEDTAGVpMSLF-VWACAGGAIGAPMATG-VDINAKYGWRWLYyinIIVGGFFLIVILII 257
Cdd:COG0738   113 LDVAANPYVAALGPETAASR-LNLLhAFFSLGALLGPLLGGLlILLGLSLSWHLPY---LILAVLLLLLALLF 181
MFS_Amf1_MDR_like cd17476
Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole ...
 110-253 7.12e-03

Saccharomyces cerevisiae low affinity ammonium transporter Amf1p/YOR378W, aminotriazole resistance protein Atr1p, and similar transporters of the Major Facilitator Superfamily; Saccharomyces cerevisiae Amf1p/Ammonium Facilitator 1/YOR378W functions as a low affinity NH4+ transporter. S. cerevisiae aminotriazole resistance protein (Atr1p) is required for controlling sensitivity to aminotriazole; it is a putative component of the machinery responsible for pumping aminotriazole (and possibly other toxic compounds) out of the cell. This subfamily also includes S. cerevisiae YMR279C, a putative boron transporter involved in boron efflux and resistance, and Kluyveromyces lactis Knq1p which is involved in oxidative stress response and iron homeostasis. Amf1p, Atr1p, and YMR279C have been classified as group 1 members of the DHA2 (Drug:H+ Antiporter family 2) family, K. lactis Knq1 as group 2. This subfamily also includes two Aspergillus terreus terrein biosynthesis cluster proteins, efflux pump TerG and TerJ which may be required for efficient secretion of terrein or other secondary metabolites produced by the terrein gene cluster. The Amf1p-like subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341029 [Multi-domain]  Cd Length: 362  Bit Score: 38.78  E-value: 7.12e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742890 110 AQFNVSAQVATLCLSMNILGSGLGPMFLGPLSDIGGRKPVYFCSIFVYTVFNISCALPRNIVQMIISHFIIGVAGSTALT 189
Cdd:cd17476    26 DSFGTSPNQLSWLAASYSLTVGTFILIFGRLGDIYGHKKMFVIGSFWFAIWSLIAGFSPNFIFFIICRALQGLGPAFLLP 105

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1246742890 190 NVAGGIPDLFPEDTA-GVPMSLF-VWACAGGAIGAPMATGVDINAkyGWRWLYYINIIVGGFFLIV 253
Cdd:cd17476   106 NAMALLGRTYPPGPRkNIVFSLFgATAPLGFALGGVFGGLFAQLA--WWPWIFWFLAILAAIVAVA 169
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH