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Conserved domains on  [gi|1246742811|ref|NP_001342837|]
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exocyst complex subunit Exo84 [Schizosaccharomyces pombe]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Exo84_C super family cl24934
Exocyst component 84 C-terminal; Exo84_C is the C-terminal helical region of the exocyst ...
 374-563 1.52e-14

Exocyst component 84 C-terminal; Exo84_C is the C-terminal helical region of the exocyst component Exo84. This region resembles a cullin-repeat, a multi-helical bundle. The exocyst is a large complex that is required for tethering vesicles at the final stages of the exocytic pathway in all eukaryotes. Exocyst subunits are composed of mostly helical modules strung together into long rods.


The actual alignment was detected with superfamily member pfam16528:

Pssm-ID: 465161  Cd Length: 203  Bit Score: 72.64  E-value: 1.52e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742811 374 QFDHLDIQISLQEFTDAIRNLALIQNKLE---RG-NLNELFA-EFFADKLHNRKRKVTEILLHQLGFKGiSLSHGKEIVR 448
Cdd:pfam16528   6 LPEELDIDIARRNFEEAVDLLEKLESKLKdlaDGlKDNEAILhDLINLKVDQRREKLASKLSRSLLSTN-EVTKLKRNVS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742811 449 YLRSLGHEKEGQGVFMKSRTLLIKEKCLNVQLEKDTPNFIDACAFIVFRCLAQTTSSYLQLFELKKLDPAYRNWIFQQIE 528
Cdd:pfam16528  85 WLIRLGLEDRARELFLENRSNLIQKRIRQIGFEGDLTLYITQLAVVRFTLIKNTVQEFQECFPDNKMSSALVKWAKEEVD 164

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1246742811 529 ALVDLIENQYkhLAHDRSYTDAVSKIMTYNTELKE 563
Cdd:pfam16528 165 KFFDLLSRQL--LNDEMVSPECIKIARKQADDLKE 197
Vps51 super family cl46298
Vps51/Vps67; This family includes a presumed domain found in a number of components of ...
 70-146 6.80e-03

Vps51/Vps67; This family includes a presumed domain found in a number of components of vesicular transport. The VFT tethering complex (also known as GARP complex, Golgi associated retrograde protein complex, Vps53 tethering complex) is a conserved eukaryotic docking complex which is involved recycling of proteins from endosomes to the late Golgi. Vps51 (also known as Vps67) is a subunit of VFT and interacts with the SNARE Tlg1. Cog1_N is the N-terminus of the Cog1 subunit of the eight-unit Conserved Oligomeric Golgi (COG) complex that participates in retrograde vesicular transport and is required to maintain normal Golgi structure and function. The subunits are located in two lobes and Cog1 serves to bind the two lobes together probably via the highly conserved N-terminal domain of approximately 85 residues.


The actual alignment was detected with superfamily member pfam08700:

Pssm-ID: 480638  Cd Length: 86  Bit Score: 36.10  E-value: 6.80e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1246742811  70 FDNQNFDAQSYLNDVLQDLSEDEFVSLYNKLLRIHMGVRKNLEKNFYKNLNEYVFISGEVESMTSDFKKFQSLLKTL 146
Cdd:pfam08700   1 LDSPSFDADRYVSELLSKATLEELLQFESSLRSEIERLDSELKQLVYDNYRDLIKAADTISKMKSEMEQLSQKLSEL 77
 
Name Accession Description Interval E-value
Exo84_C pfam16528
Exocyst component 84 C-terminal; Exo84_C is the C-terminal helical region of the exocyst ...
 374-563 1.52e-14

Exocyst component 84 C-terminal; Exo84_C is the C-terminal helical region of the exocyst component Exo84. This region resembles a cullin-repeat, a multi-helical bundle. The exocyst is a large complex that is required for tethering vesicles at the final stages of the exocytic pathway in all eukaryotes. Exocyst subunits are composed of mostly helical modules strung together into long rods.


Pssm-ID: 465161  Cd Length: 203  Bit Score: 72.64  E-value: 1.52e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742811 374 QFDHLDIQISLQEFTDAIRNLALIQNKLE---RG-NLNELFA-EFFADKLHNRKRKVTEILLHQLGFKGiSLSHGKEIVR 448
Cdd:pfam16528   6 LPEELDIDIARRNFEEAVDLLEKLESKLKdlaDGlKDNEAILhDLINLKVDQRREKLASKLSRSLLSTN-EVTKLKRNVS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742811 449 YLRSLGHEKEGQGVFMKSRTLLIKEKCLNVQLEKDTPNFIDACAFIVFRCLAQTTSSYLQLFELKKLDPAYRNWIFQQIE 528
Cdd:pfam16528  85 WLIRLGLEDRARELFLENRSNLIQKRIRQIGFEGDLTLYITQLAVVRFTLIKNTVQEFQECFPDNKMSSALVKWAKEEVD 164

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1246742811 529 ALVDLIENQYkhLAHDRSYTDAVSKIMTYNTELKE 563
Cdd:pfam16528 165 KFFDLLSRQL--LNDEMVSPECIKIARKQADDLKE 197
Vps51 pfam08700
Vps51/Vps67; This family includes a presumed domain found in a number of components of ...
 70-146 6.80e-03

Vps51/Vps67; This family includes a presumed domain found in a number of components of vesicular transport. The VFT tethering complex (also known as GARP complex, Golgi associated retrograde protein complex, Vps53 tethering complex) is a conserved eukaryotic docking complex which is involved recycling of proteins from endosomes to the late Golgi. Vps51 (also known as Vps67) is a subunit of VFT and interacts with the SNARE Tlg1. Cog1_N is the N-terminus of the Cog1 subunit of the eight-unit Conserved Oligomeric Golgi (COG) complex that participates in retrograde vesicular transport and is required to maintain normal Golgi structure and function. The subunits are located in two lobes and Cog1 serves to bind the two lobes together probably via the highly conserved N-terminal domain of approximately 85 residues.


Pssm-ID: 462568  Cd Length: 86  Bit Score: 36.10  E-value: 6.80e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1246742811  70 FDNQNFDAQSYLNDVLQDLSEDEFVSLYNKLLRIHMGVRKNLEKNFYKNLNEYVFISGEVESMTSDFKKFQSLLKTL 146
Cdd:pfam08700   1 LDSPSFDADRYVSELLSKATLEELLQFESSLRSEIERLDSELKQLVYDNYRDLIKAADTISKMKSEMEQLSQKLSEL 77
 
Name Accession Description Interval E-value
Exo84_C pfam16528
Exocyst component 84 C-terminal; Exo84_C is the C-terminal helical region of the exocyst ...
 374-563 1.52e-14

Exocyst component 84 C-terminal; Exo84_C is the C-terminal helical region of the exocyst component Exo84. This region resembles a cullin-repeat, a multi-helical bundle. The exocyst is a large complex that is required for tethering vesicles at the final stages of the exocytic pathway in all eukaryotes. Exocyst subunits are composed of mostly helical modules strung together into long rods.


Pssm-ID: 465161  Cd Length: 203  Bit Score: 72.64  E-value: 1.52e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742811 374 QFDHLDIQISLQEFTDAIRNLALIQNKLE---RG-NLNELFA-EFFADKLHNRKRKVTEILLHQLGFKGiSLSHGKEIVR 448
Cdd:pfam16528   6 LPEELDIDIARRNFEEAVDLLEKLESKLKdlaDGlKDNEAILhDLINLKVDQRREKLASKLSRSLLSTN-EVTKLKRNVS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742811 449 YLRSLGHEKEGQGVFMKSRTLLIKEKCLNVQLEKDTPNFIDACAFIVFRCLAQTTSSYLQLFELKKLDPAYRNWIFQQIE 528
Cdd:pfam16528  85 WLIRLGLEDRARELFLENRSNLIQKRIRQIGFEGDLTLYITQLAVVRFTLIKNTVQEFQECFPDNKMSSALVKWAKEEVD 164

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1246742811 529 ALVDLIENQYkhLAHDRSYTDAVSKIMTYNTELKE 563
Cdd:pfam16528 165 KFFDLLSRQL--LNDEMVSPECIKIARKQADDLKE 197
Vps51 pfam08700
Vps51/Vps67; This family includes a presumed domain found in a number of components of ...
 70-146 6.80e-03

Vps51/Vps67; This family includes a presumed domain found in a number of components of vesicular transport. The VFT tethering complex (also known as GARP complex, Golgi associated retrograde protein complex, Vps53 tethering complex) is a conserved eukaryotic docking complex which is involved recycling of proteins from endosomes to the late Golgi. Vps51 (also known as Vps67) is a subunit of VFT and interacts with the SNARE Tlg1. Cog1_N is the N-terminus of the Cog1 subunit of the eight-unit Conserved Oligomeric Golgi (COG) complex that participates in retrograde vesicular transport and is required to maintain normal Golgi structure and function. The subunits are located in two lobes and Cog1 serves to bind the two lobes together probably via the highly conserved N-terminal domain of approximately 85 residues.


Pssm-ID: 462568  Cd Length: 86  Bit Score: 36.10  E-value: 6.80e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1246742811  70 FDNQNFDAQSYLNDVLQDLSEDEFVSLYNKLLRIHMGVRKNLEKNFYKNLNEYVFISGEVESMTSDFKKFQSLLKTL 146
Cdd:pfam08700   1 LDSPSFDADRYVSELLSKATLEELLQFESSLRSEIERLDSELKQLVYDNYRDLIKAADTISKMKSEMEQLSQKLSEL 77
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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