NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1246742829|ref|NP_001342939|]
View 

CCR4-Not complex subunit Caf4/Mdv1 [Schizosaccharomyces pombe]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 10077586)

WD40 repeat domain-containing protein similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 324-650 2.44e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


:

Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 182.15  E-value: 2.44e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 324 LVKQFQAHSEYITSLDFSHPFGTLATASTDKTVKVWDMAGVVYLGSLKGHSD-YVSCLAIQDS-FIATGSMDTTVRLWNL 401
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGpVRDVAASADGtYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 402 DNDVLhkdnpveeslnsppdqpvdnaTNVLTSHTAPVTALALSSDD-VLITGADDKTVRQWDIVTGRCIQTLdfvwaETH 480
Cdd:cd00200    81 ETGEC---------------------VRTLTGHTSYVSSVAFSPDGrILSSSSRDKTIKVWDVETGKCLTTL-----RGH 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 481 DTSTSQILVSDTykqepfiraldclDAAVASGTVDGLIRIWDLRIGLPVRSFIGHTAPISSLQF--DSNHLYSGSYDNSV 558
Cdd:cd00200   135 TDWVNSVAFSPD-------------GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFspDGEKLLSSSSDGTI 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 559 RIWDLRSGSPINIIP-MEKKVNSLRLYQGR--LAVASDEPNVRIFDTVSNRNwICSIPSHSDSIaaepnsvpTSVQYKD- 634
Cdd:cd00200   202 KLWDLSTGKCLGTLRgHENGVNSVAFSPDGylLASGSEDGTIRVWDLRTGEC-VQTLSGHTNSV--------TSLAWSPd 272

                         330
                  ....*....|....*..
gi 1246742829 635 -RFLVDGKSDGSVSVFS 650
Cdd:cd00200   273 gKRLASGSADGTIRIWD 289
Mdv1_N super family cl13121
N-terminal extended coiled-coil domain of Saccharomyces cerevisiae mitochondrial division ...
 98-228 8.65e-10

N-terminal extended coiled-coil domain of Saccharomyces cerevisiae mitochondrial division protein 1 (Mdv1) and similar proteins; Mdv1, also known as mitochondrial fission 2 protein (FIS2), GAG3, or NET2, is involved in the mitochondrial fission machinery of the yeast Saccharomyces cerevisiae. Together with Fis1 and Dnm1, Mdv1 is an essential component of the machinery that mediates mitochondrial fission, a process crucial for mitochondrial maintenance and function. Mdv1 is an adapter protein that binds Fis1 and Dnm1 to form mitochondrial fission complexes, which facilitate the constriction and fission of the mitochondrial compartment during the late stages of mitochondrial division. Mdv1 works together with Caf4 to recruit Dnm1 to Fis1 on the mitochondrial outer membrane. Mdv1 protein has three domains: N-terminal extension, central coiled coil (CC), and C-terminal WD40 repeat region. The N-terminal extension binds to Fis1, while the CC domain facilitates dimerization of Mdv1 and is responsible for the recruitment of Dnm1 to the mitochondrial membrane. Both are included in this model. The C-terminal WD40 repeat region binds to Dnm1.


The actual alignment was detected with superfamily member cd22881:

Pssm-ID: 472421  Cd Length: 108  Bit Score: 56.37  E-value: 8.65e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829  98 LPDPLLFDIPDH-QETSYSLLEGYSVTahdhsdtspLPITSSNqkegkknvssidvsmvsdssefkpdslqhekLVKKCN 176
Cdd:cd22881     9 LPDELLNDIPEDgEDSSYSLFQGFQAT---------LPEEKED-------------------------------INHKLD 48

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1246742829 177 QLRLQKLINSSELAQIDLELSKLYSRRRQVLERLSKIEEQNLKYTSKLASVE 228
Cdd:cd22881    49 LLEIRKNLAASEIREIDNKIANLNSMRKIVFERIAKLEKEELELENELEEIK 100
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 324-650 2.44e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 182.15  E-value: 2.44e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 324 LVKQFQAHSEYITSLDFSHPFGTLATASTDKTVKVWDMAGVVYLGSLKGHSD-YVSCLAIQDS-FIATGSMDTTVRLWNL 401
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGpVRDVAASADGtYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 402 DNDVLhkdnpveeslnsppdqpvdnaTNVLTSHTAPVTALALSSDD-VLITGADDKTVRQWDIVTGRCIQTLdfvwaETH 480
Cdd:cd00200    81 ETGEC---------------------VRTLTGHTSYVSSVAFSPDGrILSSSSRDKTIKVWDVETGKCLTTL-----RGH 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 481 DTSTSQILVSDTykqepfiraldclDAAVASGTVDGLIRIWDLRIGLPVRSFIGHTAPISSLQF--DSNHLYSGSYDNSV 558
Cdd:cd00200   135 TDWVNSVAFSPD-------------GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFspDGEKLLSSSSDGTI 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 559 RIWDLRSGSPINIIP-MEKKVNSLRLYQGR--LAVASDEPNVRIFDTVSNRNwICSIPSHSDSIaaepnsvpTSVQYKD- 634
Cdd:cd00200   202 KLWDLSTGKCLGTLRgHENGVNSVAFSPDGylLASGSEDGTIRVWDLRTGEC-VQTLSGHTNSV--------TSLAWSPd 272

                         330
                  ....*....|....*..
gi 1246742829 635 -RFLVDGKSDGSVSVFS 650
Cdd:cd00200   273 gKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
322-602 4.81e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 168.17  E-value: 4.81e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 322 GNLVKQFQAHSEYITSLDFShPFG-TLATASTDKTVKVWDMAGVVYLGSLKGHSDYVSCLAI--QDSFIATGSMDTTVRL 398
Cdd:COG2319   152 GKLLRTLTGHSGAVTSVAFS-PDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKLLASGSADGTVRL 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 399 WNLDNDVLHKdnpveeslnsppdqpvdnatnVLTSHTAPVTALALSSDD-VLITGADDKTVRQWDIVTGRCIQTLDfvwa 477
Cdd:COG2319   231 WDLATGKLLR---------------------TLTGHSGSVRSVAFSPDGrLLASGSADGTVRLWDLATGELLRTLT---- 285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 478 eTHDTSTSQILVSDTYKQepfiraldcldaaVASGTVDGLIRIWDLRIGLPVRSFIGHTAPISSLQF--DSNHLYSGSYD 555
Cdd:COG2319   286 -GHSGGVNSVAFSPDGKL-------------LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKTLASGSDD 351

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1246742829 556 NSVRIWDLRSGSPINIIPM-EKKVNSLRL-YQGR-LAVASDEPNVRIFDT 602
Cdd:COG2319   352 GTVRLWDLATGELLRTLTGhTGAVTSVAFsPDGRtLASGSADGTVRLWDL 401
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 332-600 6.87e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 62.41  E-value: 6.87e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 332 SEYITSLDFSHPFGTLATASTDKTVKVWDMAGVVYLG--------SLKGHSDYVSCL--AIQDSFIATGSMDTTVRLWNL 401
Cdd:PLN00181  483 SNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGrdihypvvELASRSKLSGICwnSYIKSQVASSNFEGVVQVWDV 562

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 402 DNDVLhkdnpVEEslnsppdqpvdnatnvLTSHTAPVTALALSSDD--VLITGADDKTVRQWDIVTGRCIQTLdfvwaET 479
Cdd:PLN00181  563 ARSQL-----VTE----------------MKEHEKRVWSIDYSSADptLLASGSDDGSVKLWSINQGVSIGTI-----KT 616

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 480 HDTSTSQILVSDTYKqepfiraldcldaAVASGTVDGLIRIWDLR-IGLPVRSFIGHTAPISSLQF-DSNHLYSGSYDNS 557
Cdd:PLN00181  617 KANICCVQFPSESGR-------------SLAFGSADHKVYYYDLRnPKLPLCTMIGHSKTVSYVRFvDSSTLVSSSTDNT 683

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1246742829 558 VRIWDLR-SGSPINIIPME--------KKVNSLRLYQGRLAVASDEPNVRIF 600
Cdd:PLN00181  684 LKLWDLSmSISGINETPLHsfmghtnvKNFVGLSVSDGYIATGSETNEVFVY 735
Mdv1_N cd22881
N-terminal extended coiled-coil domain of Saccharomyces cerevisiae mitochondrial division ...
 98-228 8.65e-10

N-terminal extended coiled-coil domain of Saccharomyces cerevisiae mitochondrial division protein 1 (Mdv1) and similar proteins; Mdv1, also known as mitochondrial fission 2 protein (FIS2), GAG3, or NET2, is involved in the mitochondrial fission machinery of the yeast Saccharomyces cerevisiae. Together with Fis1 and Dnm1, Mdv1 is an essential component of the machinery that mediates mitochondrial fission, a process crucial for mitochondrial maintenance and function. Mdv1 is an adapter protein that binds Fis1 and Dnm1 to form mitochondrial fission complexes, which facilitate the constriction and fission of the mitochondrial compartment during the late stages of mitochondrial division. Mdv1 works together with Caf4 to recruit Dnm1 to Fis1 on the mitochondrial outer membrane. Mdv1 protein has three domains: N-terminal extension, central coiled coil (CC), and C-terminal WD40 repeat region. The N-terminal extension binds to Fis1, while the CC domain facilitates dimerization of Mdv1 and is responsible for the recruitment of Dnm1 to the mitochondrial membrane. Both are included in this model. The C-terminal WD40 repeat region binds to Dnm1.


Pssm-ID: 467856  Cd Length: 108  Bit Score: 56.37  E-value: 8.65e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829  98 LPDPLLFDIPDH-QETSYSLLEGYSVTahdhsdtspLPITSSNqkegkknvssidvsmvsdssefkpdslqhekLVKKCN 176
Cdd:cd22881     9 LPDELLNDIPEDgEDSSYSLFQGFQAT---------LPEEKED-------------------------------INHKLD 48

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1246742829 177 QLRLQKLINSSELAQIDLELSKLYSRRRQVLERLSKIEEQNLKYTSKLASVE 228
Cdd:cd22881    49 LLEIRKNLAASEIREIDNKIANLNSMRKIVFERIAKLEKEELELENELEEIK 100
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 369-457 6.17e-08

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 55.08  E-value: 6.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 369 SLKGHSDYVSCLAIQD--SFIATGSMDTTVRLWnldnDVLHKDNPVEESLNSPPDQP------VDNATNVLTSHTAPVTA 440
Cdd:pfam20426 119 SIRQHKDVVSCVAVTSdgSILATGSYDTTVMVW----EVLRGRSSEKRSRNTQTEFPrkdhviAETPFHILCGHDDIITC 194

                          90
                  ....*....|....*...
gi 1246742829 441 LALSSD-DVLITGADDKT 457
Cdd:pfam20426 195 LYVSVElDIVISGSKDGT 212
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 322-360 2.14e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 2.14e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1246742829  322 GNLVKQFQAHSEYITSLDFSHPFGTLATASTDKTVKVWD 360
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
 
Name Accession Description Interval E-value
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 324-650 2.44e-52

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 182.15  E-value: 2.44e-52
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 324 LVKQFQAHSEYITSLDFSHPFGTLATASTDKTVKVWDMAGVVYLGSLKGHSD-YVSCLAIQDS-FIATGSMDTTVRLWNL 401
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGpVRDVAASADGtYLASGSSDKTIRLWDL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 402 DNDVLhkdnpveeslnsppdqpvdnaTNVLTSHTAPVTALALSSDD-VLITGADDKTVRQWDIVTGRCIQTLdfvwaETH 480
Cdd:cd00200    81 ETGEC---------------------VRTLTGHTSYVSSVAFSPDGrILSSSSRDKTIKVWDVETGKCLTTL-----RGH 134

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 481 DTSTSQILVSDTykqepfiraldclDAAVASGTVDGLIRIWDLRIGLPVRSFIGHTAPISSLQF--DSNHLYSGSYDNSV 558
Cdd:cd00200   135 TDWVNSVAFSPD-------------GTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFspDGEKLLSSSSDGTI 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 559 RIWDLRSGSPINIIP-MEKKVNSLRLYQGR--LAVASDEPNVRIFDTVSNRNwICSIPSHSDSIaaepnsvpTSVQYKD- 634
Cdd:cd00200   202 KLWDLSTGKCLGTLRgHENGVNSVAFSPDGylLASGSEDGTIRVWDLRTGEC-VQTLSGHTNSV--------TSLAWSPd 272

                         330
                  ....*....|....*..
gi 1246742829 635 -RFLVDGKSDGSVSVFS 650
Cdd:cd00200   273 gKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
322-602 4.81e-46

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 168.17  E-value: 4.81e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 322 GNLVKQFQAHSEYITSLDFShPFG-TLATASTDKTVKVWDMAGVVYLGSLKGHSDYVSCLAI--QDSFIATGSMDTTVRL 398
Cdd:COG2319   152 GKLLRTLTGHSGAVTSVAFS-PDGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKLLASGSADGTVRL 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 399 WNLDNDVLHKdnpveeslnsppdqpvdnatnVLTSHTAPVTALALSSDD-VLITGADDKTVRQWDIVTGRCIQTLDfvwa 477
Cdd:COG2319   231 WDLATGKLLR---------------------TLTGHSGSVRSVAFSPDGrLLASGSADGTVRLWDLATGELLRTLT---- 285

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 478 eTHDTSTSQILVSDTYKQepfiraldcldaaVASGTVDGLIRIWDLRIGLPVRSFIGHTAPISSLQF--DSNHLYSGSYD 555
Cdd:COG2319   286 -GHSGGVNSVAFSPDGKL-------------LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKTLASGSDD 351

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|
gi 1246742829 556 NSVRIWDLRSGSPINIIPM-EKKVNSLRL-YQGR-LAVASDEPNVRIFDT 602
Cdd:COG2319   352 GTVRLWDLATGELLRTLTGhTGAVTSVAFsPDGRtLASGSADGTVRLWDL 401
WD40 COG2319
WD40 repeat [General function prediction only];
322-565 1.04e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 167.40  E-value: 1.04e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 322 GNLVKQFQAHSEYITSLDFSHPFGTLATASTDKTVKVWDMAGVVYLGSLKGHSDYVSCLAI--QDSFIATGSMDTTVRLW 399
Cdd:COG2319   194 GKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFspDGRLLASGSADGTVRLW 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 400 NLDNDVLHKdnpveeslnsppdqpvdnatnVLTSHTAPVTALALSSD-DVLITGADDKTVRQWDIVTGRCIQTLdfvwaE 478
Cdd:COG2319   274 DLATGELLR---------------------TLTGHSGGVNSVAFSPDgKLLASGSDDGTVRLWDLATGKLLRTL-----T 327

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 479 THDTSTSQILVSDTykqepfiraldclDAAVASGTVDGLIRIWDLRIGLPVRSFIGHTAPISSLQF--DSNHLYSGSYDN 556
Cdd:COG2319   328 GHTGAVRSVAFSPD-------------GKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFspDGRTLASGSADG 394


                  ....*....
gi 1246742829 557 SVRIWDLRS 565
Cdd:COG2319   395 TVRLWDLAT 403
WD40 COG2319
WD40 repeat [General function prediction only];
322-651 1.75e-45

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 166.63  E-value: 1.75e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 322 GNLVKQFQAHSEYITSLDFSHPFGTLATASTDKTVKVWDMAGVVYLGSLKGHSDYVSCLAI--QDSFIATGSMDTTVRLW 399
Cdd:COG2319    68 GALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFspDGKTLASGSADGTVRLW 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 400 NLDNDVLHKdnpveeslnsppdqpvdnatnVLTSHTAPVTALALSSD-DVLITGADDKTVRQWDIVTGRCIQTLdfvwaE 478
Cdd:COG2319   148 DLATGKLLR---------------------TLTGHSGAVTSVAFSPDgKLLASGSDDGTVRLWDLATGKLLRTL-----T 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 479 THDTSTSQILVS--DTYkqepfiraldcldaaVASGTVDGLIRIWDLRIGLPVRSFIGHTAPISSLQF--DSNHLYSGSY 554
Cdd:COG2319   202 GHTGAVRSVAFSpdGKL---------------LASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFspDGRLLASGSA 266

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 555 DNSVRIWDLRSGSPINIIPMEK-KVNSLRL-YQGR-LAVASDEPNVRIFDtVSNRNWICSIPSHSD---SIAAEPNsvpt 628
Cdd:COG2319   267 DGTVRLWDLATGELLRTLTGHSgGVNSVAFsPDGKlLASGSDDGTVRLWD-LATGKLLRTLTGHTGavrSVAFSPD---- 341

                         330       340
                  ....*....|....*....|...
gi 1246742829 629 svqykDRFLVDGKSDGSVSVFSA 651
Cdd:COG2319   342 -----GKTLASGSDDGTVRLWDL 359
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 318-601 2.43e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 162.89  E-value: 2.43e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 318 NYIVGNLVKQFQAHSEYITSLDFSHPFGTLATASTDKTVKVWDMAGVVYLGSLKGHSDYVSCLAIQDS--FIATGSMDTT 395
Cdd:cd00200    37 DLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSPDgrILSSSSRDKT 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 396 VRLWNLDNDVLHKdnpveeslnsppdqpvdnatnVLTSHTAPVTALALSSDDVLITGA-DDKTVRQWDIVTGRCIQTLdf 474
Cdd:cd00200   117 IKVWDVETGKCLT---------------------TLRGHTDWVNSVAFSPDGTFVASSsQDGTIKLWDLRTGKCVATL-- 173

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 475 vwaETHDTSTSQILVSDTYKQepfiraldcldaaVASGTVDGLIRIWDLRIGLPVRSFIGHTAPISSLQFDSNHLY--SG 552
Cdd:cd00200   174 ---TGHTGEVNSVAFSPDGEK-------------LLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLlaSG 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1246742829 553 SYDNSVRIWDLRSGSPINIIPM-EKKVNSLRLYQ--GRLAVASDEPNVRIFD 601
Cdd:cd00200   238 SEDGTIRVWDLRTGECVQTLSGhTNSVTSLAWSPdgKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
320-651 8.93e-38

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 145.05  E-value: 8.93e-38
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 320 IVGNLVKQFQAHSEYITSLDFSHPFGTLATASTDKTVKVWDMAGVVYLGSLKGHSDYVSCLAIQ--DSFIATGSMDTTVR 397
Cdd:COG2319    24 ALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSpdGRLLASASADGTVR 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 398 LWNLDNDVLhkdnpveeslnsppdqpvdnaTNVLTSHTAPVTALALSSD-DVLITGADDKTVRQWDIVTGRCIQTLdfvw 476
Cdd:COG2319   104 LWDLATGLL---------------------LRTLTGHTGAVRSVAFSPDgKTLASGSADGTVRLWDLATGKLLRTL---- 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 477 aETHDTSTSQILVSDTYKQepfiraldcldaaVASGTVDGLIRIWDLRIGLPVRSFIGHTAPISSLQF--DSNHLYSGSY 554
Cdd:COG2319   159 -TGHSGAVTSVAFSPDGKL-------------LASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFspDGKLLASGSA 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 555 DNSVRIWDLRSGSPINIIPM-EKKVNSLRL-YQGR-LAVASDEPNVRIFDtVSNRNWICSIPSHSDSIaaepNSVptsvq 631
Cdd:COG2319   225 DGTVRLWDLATGKLLRTLTGhSGSVRSVAFsPDGRlLASGSADGTVRLWD-LATGELLRTLTGHSGGV----NSV----- 294

                         330       340
                  ....*....|....*....|....*.
gi 1246742829 632 ykdRFLVDGK------SDGSVSVFSA 651
Cdd:COG2319   295 ---AFSPDGKllasgsDDGTVRLWDL 317
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 332-600 6.87e-10

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 62.41  E-value: 6.87e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 332 SEYITSLDFSHPFGTLATASTDKTVKVWDMAGVVYLG--------SLKGHSDYVSCL--AIQDSFIATGSMDTTVRLWNL 401
Cdd:PLN00181  483 SNLVCAIGFDRDGEFFATAGVNKKIKIFECESIIKDGrdihypvvELASRSKLSGICwnSYIKSQVASSNFEGVVQVWDV 562

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 402 DNDVLhkdnpVEEslnsppdqpvdnatnvLTSHTAPVTALALSSDD--VLITGADDKTVRQWDIVTGRCIQTLdfvwaET 479
Cdd:PLN00181  563 ARSQL-----VTE----------------MKEHEKRVWSIDYSSADptLLASGSDDGSVKLWSINQGVSIGTI-----KT 616

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 480 HDTSTSQILVSDTYKqepfiraldcldaAVASGTVDGLIRIWDLR-IGLPVRSFIGHTAPISSLQF-DSNHLYSGSYDNS 557
Cdd:PLN00181  617 KANICCVQFPSESGR-------------SLAFGSADHKVYYYDLRnPKLPLCTMIGHSKTVSYVRFvDSSTLVSSSTDNT 683

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1246742829 558 VRIWDLR-SGSPINIIPME--------KKVNSLRLYQGRLAVASDEPNVRIF 600
Cdd:PLN00181  684 LKLWDLSmSISGINETPLHsfmghtnvKNFVGLSVSDGYIATGSETNEVFVY 735
Mdv1_N cd22881
N-terminal extended coiled-coil domain of Saccharomyces cerevisiae mitochondrial division ...
 98-228 8.65e-10

N-terminal extended coiled-coil domain of Saccharomyces cerevisiae mitochondrial division protein 1 (Mdv1) and similar proteins; Mdv1, also known as mitochondrial fission 2 protein (FIS2), GAG3, or NET2, is involved in the mitochondrial fission machinery of the yeast Saccharomyces cerevisiae. Together with Fis1 and Dnm1, Mdv1 is an essential component of the machinery that mediates mitochondrial fission, a process crucial for mitochondrial maintenance and function. Mdv1 is an adapter protein that binds Fis1 and Dnm1 to form mitochondrial fission complexes, which facilitate the constriction and fission of the mitochondrial compartment during the late stages of mitochondrial division. Mdv1 works together with Caf4 to recruit Dnm1 to Fis1 on the mitochondrial outer membrane. Mdv1 protein has three domains: N-terminal extension, central coiled coil (CC), and C-terminal WD40 repeat region. The N-terminal extension binds to Fis1, while the CC domain facilitates dimerization of Mdv1 and is responsible for the recruitment of Dnm1 to the mitochondrial membrane. Both are included in this model. The C-terminal WD40 repeat region binds to Dnm1.


Pssm-ID: 467856  Cd Length: 108  Bit Score: 56.37  E-value: 8.65e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829  98 LPDPLLFDIPDH-QETSYSLLEGYSVTahdhsdtspLPITSSNqkegkknvssidvsmvsdssefkpdslqhekLVKKCN 176
Cdd:cd22881     9 LPDELLNDIPEDgEDSSYSLFQGFQAT---------LPEEKED-------------------------------INHKLD 48

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 1246742829 177 QLRLQKLINSSELAQIDLELSKLYSRRRQVLERLSKIEEQNLKYTSKLASVE 228
Cdd:cd22881    49 LLEIRKNLAASEIREIDNKIANLNSMRKIVFERIAKLEKEELELENELEEIK 100
NBCH_WD40 pfam20426
Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at ...
 369-457 6.17e-08

Neurobeachin beta propeller domain; This entry represents the beta propeller domain found at the C-terminus of neurobeachin-like proteins.


Pssm-ID: 466575 [Multi-domain]  Cd Length: 350  Bit Score: 55.08  E-value: 6.17e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 369 SLKGHSDYVSCLAIQD--SFIATGSMDTTVRLWnldnDVLHKDNPVEESLNSPPDQP------VDNATNVLTSHTAPVTA 440
Cdd:pfam20426 119 SIRQHKDVVSCVAVTSdgSILATGSYDTTVMVW----EVLRGRSSEKRSRNTQTEFPrkdhviAETPFHILCGHDDIITC 194

                          90
                  ....*....|....*...
gi 1246742829 441 LALSSD-DVLITGADDKT 457
Cdd:pfam20426 195 LYVSVElDIVISGSKDGT 212
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 322-360 2.14e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 2.14e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1246742829  322 GNLVKQFQAHSEYITSLDFSHPFGTLATASTDKTVKVWD 360
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 526-562 2.48e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 47.31  E-value: 2.48e-07
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1246742829  526 GLPVRSFIGHTAPISSLQF--DSNHLYSGSYDNSVRIWD 562
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
526-562 7.92e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 45.80  E-value: 7.92e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1246742829 526 GLPVRSFIGHTAPISSLQF--DSNHLYSGSYDNSVRIWD 562
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFspDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
322-360 2.54e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 2.54e-06
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 1246742829 322 GNLVKQFQAHSEYITSLDFSHPFGTLATASTDKTVKVWD 360
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
367-400 1.71e-05

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 41.95  E-value: 1.71e-05
                          10        20        30
                  ....*....|....*....|....*....|....*.
gi 1246742829 367 LGSLKGHSDYVSCLAIQ--DSFIATGSMDTTVRLWN 400
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSpdGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 367-400 4.36e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 4.36e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1246742829  367 LGSLKGHSDYVSCLAI--QDSFIATGSMDTTVRLWN 400
Cdd:smart00320   5 LKTLKGHTGPVTSVAFspDGKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
430-462 1.19e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.64  E-value: 1.19e-04
                          10        20        30
                  ....*....|....*....|....*....|....
gi 1246742829 430 VLTSHTAPVTALALSSD-DVLITGADDKTVRQWD 462
Cdd:pfam00400   6 TLEGHTGSVTSLAFSPDgKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 429-462 1.30e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.30e-04
                           10        20        30
                   ....*....|....*....|....*....|....*
gi 1246742829  429 NVLTSHTAPVTALALSSDD-VLITGADDKTVRQWD 462
Cdd:smart00320   6 KTLKGHTGPVTSVAFSPDGkYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 504-582 3.07e-04

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 43.79  E-value: 3.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 504 CLDAAVASGTVDGLIRIWDLR--------IGLPVRSFIGHTAPISSLQFDSNHLY---SGSYDNSVRIWDLRSGSPINII 572
Cdd:PTZ00420   85 CFSEILASGSEDLTIRVWEIPhndesvkeIKDPQCILKGHKKKISIIDWNPMNYYimcSSGFDSFVNIWDIENEKRAFQI 164

                          90
                  ....*....|
gi 1246742829 573 PMEKKVNSLR 582
Cdd:PTZ00420  165 NMPKKLSSLK 174
PTZ00421 PTZ00421
coronin; Provisional
 312-398 3.45e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 43.73  E-value: 3.45e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1246742829 312 ESSVNQNyIVGNLVkQFQAHSEYITSLDFsHP--FGTLATASTDKTVKVWDMAGVVYLGSLKGHSDYVSCLA--IQDSFI 387
Cdd:PTZ00421  107 EEGLTQN-ISDPIV-HLQGHTKKVGIVSF-HPsaMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEwnLDGSLL 183

                          90
                  ....*....|.
gi 1246742829 388 ATGSMDTTVRL 398
Cdd:PTZ00421  184 CTTSKDKKLNI 194
PTZ00420 PTZ00420
coronin; Provisional
 509-564 1.21e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 41.86  E-value: 1.21e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1246742829 509 VASGTVDGLIRIWDLRIGLPVRSFIGHTAPISSLQFD---SNHLYSGSYDNSVRIWDLR 564
Cdd:PTZ00420   47 VEGGGLIGAIRLENQMRKPPVIKLKGHTSSILDLQFNpcfSEILASGSEDLTIRVWEIP 105
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH