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Conserved domains on  [gi|1254050727|ref|NP_001343592|]
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Serpentine Receptor, class H [Caenorhabditis elegans]

Protein Classification

class H serpentine receptor( domain architecture ID 10563391)

class H serpentine receptor (Srh) belongs to a family of seven-transmembrane (7TM) G protein-coupled receptors involved in chemoreception, a central sense of soil nematodes like Caenorhabditis elegans, and is related to the Str, Stl, and Srd families of 7TM serpentine receptors

CATH:  1.20.1070.10
Gene Ontology:  GO:0004888
PubMed:  10673277|23140243

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
8-308 9.43e-106

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


:

Pssm-ID: 402095  Cd Length: 302  Bit Score: 311.40  E-value: 9.43e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254050727   8 ASPQFFSLTLYTIGLFSFPINLFGAYCIVFQTPESMKSVKWSMFNMHFWSSFEDITVSLLVQPYLLKSTWAGIPYGILKE 87
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254050727  88 FHVPLTLQAYILSTSLCMLAVSIITIFENRYFLLFA--EHTWWRFARRPFLAINYTLAILYYVPTVLSAPDQTSARAVTF 165
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTnkKRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254050727 166 KEFPEFRKLDTPENPIYVLVLDNPWVSARQIAMEVTYLTEALSLVFLLKYNMKNATKgVKMSENTSRLQKAFLKALYTQT 245
Cdd:pfam10318 161 KKLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVK-SSLSKKTRKLQKKFFIALIIQV 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1254050727 246 SLPFMVILVPSVVSIFSGILEISTQSVNNLVYITLSCHGLASTTVMLLIQKPYREFCLGIVGK 308
Cdd:pfam10318 240 SIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
8-308 9.43e-106

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 311.40  E-value: 9.43e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254050727   8 ASPQFFSLTLYTIGLFSFPINLFGAYCIVFQTPESMKSVKWSMFNMHFWSSFEDITVSLLVQPYLLKSTWAGIPYGILKE 87
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254050727  88 FHVPLTLQAYILSTSLCMLAVSIITIFENRYFLLFA--EHTWWRFARRPFLAINYTLAILYYVPTVLSAPDQTSARAVTF 165
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTnkKRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254050727 166 KEFPEFRKLDTPENPIYVLVLDNPWVSARQIAMEVTYLTEALSLVFLLKYNMKNATKgVKMSENTSRLQKAFLKALYTQT 245
Cdd:pfam10318 161 KKLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVK-SSLSKKTRKLQKKFFIALIIQV 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1254050727 246 SLPFMVILVPSVVSIFSGILEISTQSVNNLVYITLSCHGLASTTVMLLIQKPYREFCLGIVGK 308
Cdd:pfam10318 240 SIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
 
Name Accession Description Interval E-value
7TM_GPCR_Srh pfam10318
Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis ...
8-308 9.43e-106

Serpentine type 7TM GPCR chemoreceptor Srh; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srh is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402095  Cd Length: 302  Bit Score: 311.40  E-value: 9.43e-106
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254050727   8 ASPQFFSLTLYTIGLFSFPINLFGAYCIVFQTPESMKSVKWSMFNMHFWSSFEDITVSLLVQPYLLKSTWAGIPYGILKE 87
Cdd:pfam10318   1 ASPDFLSTSLHIITVISIPIHIFGFYCILFKTPKKMKSVKWSLLNLHFWSALLDLSLSFLTIPYIFLPALAGYPLGLLSY 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254050727  88 FHVPLTLQAYILSTSLCMLAVSIITIFENRYFLLFA--EHTWWRFARRPFLAINYTLAILYYVPTVLSAPDQTSARAVTF 165
Cdd:pfam10318  81 LGVPTPIQFYIGVTSLALVGVSIILLFENRYSILFTnkKRITWKKTRVLYLIFNYIIALLFLIPIYLNIPDQEAAKLKVL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254050727 166 KEFPEFRKLDTPENPIYVLVLDNPWVSARQIAMEVTYLTEALSLVFLLKYNMKNATKgVKMSENTSRLQKAFLKALYTQT 245
Cdd:pfam10318 161 KKLPCLPPEFFDNPPVFVLAIDSTYFLICIVLLILILIIQILFFVFLTIYYLFKSVK-SSLSKKTRKLQKKFFIALIIQV 239
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1254050727 246 SLPFMVILVPSVVSIFSGILEISTQSVNNLVYITLSCHGLASTTVMLLIQKPYREFCLGIVGK 308
Cdd:pfam10318 240 SIPLIVILIPLIYILFSIIFGYYNQALNNLLFIIISLHGLLSTIAMLLVHKPYRKFVLSLFKK 302
7TM_GPCR_Sri pfam10327
Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis ...
7-301 4.02e-15

Serpentine type 7TM GPCR chemoreceptor Sri; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Sri is part of the Str superfamily of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 313539  Cd Length: 303  Bit Score: 74.50  E-value: 4.02e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254050727   7 FASPQFFSLTLYTIGLFSFPINLFGAYCIVFQTPEsMKSVKWSMFNMHFWSSFEDITVSLLVQPYLLKSTWAGIPYGIL- 85
Cdd:pfam10327   5 FTVPFWLILYYHIIGTISLILNLLGIYLIIFKSGK-IDNFRYYLLYFQISCTLTDIHLTFLMQPIPLFPIIAGYCNGFLa 83
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254050727  86 KEFHVPLTLQAYILSTSLCMLAVSIITIFENRY---FLLFAEHTWWRFARRPFLAINYTLAILYYVPTVLSAPDQTSARA 162
Cdd:pfam10327  84 TVFGISSHYLMTIFVFLLSFQLESLLLCFVRKHqaiAKILSKHVIPKWLYIFLYILCHIFPFLTAFLFYQSGLSREEQLE 163
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254050727 163 VTFKEFPE----FRKLDTPEnpIYVLvldNPWVsARQIAMEVTYLTEALSLVFLLKYNMKNATKGVK--MSENTSRLQKA 236
Cdd:pfam10327 164 YVKENYPEylsqFSSLPNFA--IYDY---NPWL-IVFGILAIFGGSLSFLILVYLTVDMFRMLKRLRkkISAQTYQKHRA 237
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1254050727 237 FLKALYTQTSLPFMVILVPSVVS-IFSGILEISTQSVNNLVYItLSCHGLASTTVMLLIQKPYREF 301
Cdd:pfam10327 238 ALRSLIAQFATSPVCILPPFAFVvVVLFPIEYSQEISEILLAI-FSTHSSVNSIVLILTTPPYRKF 302
7TM_GPCR_Str pfam10326
Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis ...
22-281 1.20e-04

Serpentine type 7TM GPCR chemoreceptor Str; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Str is a member of the Str superfamily of chemoreceptors. Almost a quarter (22.5%) of str and srj family genes and pseudogenes in C. elegans appear to have been newly formed by gene duplications since the species split. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'.


Pssm-ID: 402099  Cd Length: 307  Bit Score: 43.21  E-value: 1.20e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254050727  22 LFSFPINLFGAYCIVFQTPESMKSVKWSMFnmhFWSSFEDI--TVSLLVQPYLLKSTWAGIPYGILKEFHVPLTLqAYIL 99
Cdd:pfam10326  10 FLSILLNSILIYLILFKSPKIFGTYKYLMI---YFSIFGIFfsILEFIVKPFIHSYNSSFIVFVDLKDLGLSKSV-GQIL 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254050727 100 STSLC---MLAVSIITI-FENRYFLLFAEHTWWRFARRPF---LAINYTLAILYYVPTVLSAPDQTSARAVTFKEFPEFR 172
Cdd:pfam10326  86 LALYCgfyGVSISLLAVqFIYRYLALCRPGKLKYFDGKKLilwFLYPLIFGAIWGLLVYFFLGPDEETDEYLREELLENY 165
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254050727 173 KLDTPENPIYVLVL------DNPWVSARQIA--------MEVTYLTealSLVFLLK--YNMKNATKgvKMSENTSRLQKA 236
Cdd:pfam10326 166 NLDIDEVAYVGPVYyptdenGSKVIRWRSLIgllimtfiIGISFSI---IIYCGIKmyFKMKKLKS--LGSEKTRKLQKQ 240
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*
gi 1254050727 237 FLKALYTQTSLPFMVILVPSVVSIFSGILEISTQSVNNLVYITLS 281
Cdd:pfam10326 241 LFKALVIQTLIPTILMYIPVGILFLLPLFNIEIGFLSGIITATIA 285
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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