BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679 108 DRETLCDMAKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKW--NGDKFDLELVEDELCQKAFAPFLRFMY 185
Cdd:cd18292     1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWwsESKQSEIELVEDPECAAVFEKFLRYLY 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1254004679 186 SNHVVLHKDNCLPLLVLADKYNVTTLKKVCLDFA 219
Cdd:cd18292    81 TGQISVNLETALPLLMLADKYNVTDLKQLCVDFM 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679 108 DRETLCDMAKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKW--NGDKFDLELVEDELCQKAFAPFLRFMY 185
Cdd:cd18292     1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWwsESKQSEIELVEDPECAAVFEKFLRYLY 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1254004679 186 SNHVVLHKDNCLPLLVLADKYNVTTLKKVCLDFA 219
Cdd:cd18292    81 TGQISVNLETALPLLMLADKYNVTDLKQLCVDFM 114

BTB/POZ domain; The BTB (for BR-C, ttk and bab) or POZ (for Pox virus and Zinc finger) domain is present near the N-terminus of a fraction of zinc finger (pfam00096) proteins and in proteins that contain the pfam01344 motif such as Kelch and a family of pox virus proteins. The BTB/POZ domain mediates homomeric dimerization and in some instances heteromeric dimerization. The structure of the dimerized PLZF BTB/POZ domain has been solved and consists of a tightly intertwined homodimer. The central scaffolding of the protein is made up of a cluster of alpha-helices flanked by short beta-sheets at both the top and bottom of the molecule. POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes including N-CoR and SMRT. The POZ or BTB domain is also known as BR-C/Ttk or ZiN.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679 117 KFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDKFDlELVEDELCQKAFAPFLRFMYSNHVVlHKDNC 196
Cdd:pfam00651   3 ELREQGELCDVTLVVGDKEFRAHKAVLAACSPYFKALFSGQESESSVS-EITLDDVSPEDFEALLEFMYTGKLI-SEENV 80

                          90       100
                  ....*....|....*....|..
gi 1254004679 197 LPLLVLADKYNVTTLKKVCLDF 218
Cdd:pfam00651  81 DDLLAAADKLQIPSLVDKCEEF 102

BACK (BTB and C-terminal Kelch) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also termed galectin-3-binding protein-like, is a BTB-domain-containing Kelch-like protein. Its function remains unclear. It may be involved in hepatocellular carcinoma development and progression.

                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679 236 WFSYATKAYHPSLIKSCMQAIALEFETLLTEEwekDWQELHRDQMIEILKCNNLKVASEFKLWEALQKWI 305
Cdd:cd18493     8 WLQYAKMCGHKELAEACLEFIAWNFEKVLKSP---DWLNLDLDLLVSLLQSSDLVVEDEYTLFQAVEKWL 74

BTB And C-terminal Kelch; This domain is found associated with pfam00651 and pfam01344. The BACK domain is found juxtaposed to the BTB domain; they are separated by as little as two residues. This family appears to be closely related to the BTB domain (Finn RD, personal observation).

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679 236 WFSYATKAYHPSLIKSCMQAIALEFETLLTEEwekDWQELHRDQMIEILKCNNLKVASEFKLWEALQKWIQapNHSERRg 315
Cdd:pfam07707   4 IYRFADAYGCTELAEAALRFILQNFLEVAKSE---EFLELSLEQLLELLSSDDLNVPSEEEVFEAVIRWVK--HDVERR- 77

                          90
                  ....*....|....*....
gi 1254004679 316 ntaGPLLAFLLPLIRFPFM 334
Cdd:pfam07707  78 ---KKHLPELLSAVRLPLL 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 17 (BTBD17); BTBD17, also called galectin-3-binding protein-like, is a BTB domain-containing protein. Its function remains unclear. It may be associated with hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679 108 DRETLCDMAKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKW--NGDKFDLELVEDELCQKAFAPFLRFMY 185
Cdd:cd18292     1 SREFLQDIAQLYNNEELSDIVLRVGGKVFHAHRLILAKSSDVFRVMLSNDWwsESKQSEIELVEDPECAAVFEKFLRYLY 80

                          90       100       110
                  ....*....|....*....|....*....|....
gi 1254004679 186 SNHVVLHKDNCLPLLVLADKYNVTTLKKVCLDFA 219
Cdd:cd18292    81 TGQISVNLETALPLLMLADKYNVTDLKQLCVDFM 114

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing (ZBTB) proteins, Kelch-like (KLHL) proteins, and similar proteins; This family includes a variety of BTB/POZ domain-containing proteins, such as zinc finger and BTB domain-containing (ZBTB) proteins and Kelch-like (KLHL) proteins. They have diverse functions, such as transcriptional regulation, chromatin remodeling, protein degradation and cytoskeletal regulation. Many BTB/POZ proteins contain one or two additional domains, such as kelch repeats, zinc-finger domains, FYVE (Fab1, YOTB, Vac1, and EEA1) fingers, or ankyrin repeats. These special additional domains or interaction partners provide unique characteristics and functions to BTB/POZ proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679 124 FSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKW---NGDKFDLELVEDElcqkAFAPFLRFMYSNHVVLHKDNCLPLL 200
Cdd:cd18186     1 LCDVTLVVGGREFPAHRAVLAARSPYFRAMFSSGMkesSSSEIELDDVSPE----AFEALLDYIYTGELELSEENVEELL 76

                  ....*.
gi 1254004679 201 VLADKY 206
Cdd:cd18186    77 AAADKL 82

Broad-Complex, Tramtrack and Bric a brac; Domain in Broad-Complex, Tramtrack and Bric a brac. Also known as POZ (poxvirus and zinc finger) domain. Known to be a protein-protein interaction motif found at the N-termini of several C2H2-type transcription factors as well as Shaw-type potassium channels. Known structure reveals a tightly intertwined dimer formed via interactions between N-terminal strand and helix structures. However in a subset of BTB/POZ domains, these two secondary structures appear to be missing. Be aware SMART predicts BTB/POZ domains without the beta1- and alpha1-secondary structures.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679  126 DVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEDeLCQKAFAPFLRFMYSNHVVLHKDNCLPLLVLADK 205
Cdd:smart00225   1 DVTLVVGGKKFHAHKAVLAAHSPYFKALFSSDFKESDKSEIYLDD-VSPEDFRALLNFLYTGKLDLPEENVEELLELADY 79

                           90
                   ....*....|...
gi 1254004679  206 YNVTTLKKVCLDF 218
Cdd:smart00225  80 LQIPGLVELCEEF 92

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing proteins, BTBD1 and BTBD2; This family includes BTB/POZ domain-containing proteins BTBD1 and BTBD2, both of which are BTB-domain-containing Kelch-like proteins that interact with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679 115 MAKFYNNAQFSDVNMKVG----EESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEDElcQKAFAPFLRFMYSNHVV 190
Cdd:cd18281    13 FAFLFNNETLSDVHFIVGkgdnEQRIPAHKFVLSIGSAVFDAMFNGGMATTSAEIELPDVE--PAAFLALLRFLYSDEVQ 90

                          90       100       110
                  ....*....|....*....|....*....|....*
gi 1254004679 191 LHKDNCLPLLVLADKYNVTTLKKVCLDFAQSEILP 225
Cdd:cd18281    91 IGPETVMTTLYTAKKYAVPALESACVEFLKKNLSS 125

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 8 (KLHL8); KLHL8 is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for the ubiquitination and degradation of rapsyn, a postsynaptic protein required for clustering of nicotinic acetylcholine receptors (nAChRs) at the neuromuscular junction. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679 118 FYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEDeLCQKAFAPFLRFMYSNHVVLHKDNCL 197
Cdd:cd18238     9 FYENGELCDVTLKVGEKSIHCHRLVLACVSPYFRAMFTSEMAESKQDSITIKD-IDEEAVELLVDFAYTGKLTLTVDNVQ 87

                          90       100
                  ....*....|....*....|....*...
gi 1254004679 198 PLLVLADKYNVTTLKKVCLDFAQSEILP 225
Cdd:cd18238    88 SLLYAASLLQVEEVAKACCEFMKDHLHP 115

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 6 (BTBD6); BTBD6, also termed lens BTB domain protein, is a BTB-domain-containing Kelch-like protein required for proper embryogenesis and plays an essential evolutionary conserved role during neuronal development. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679 119 YNNAQFSDVNMKVG----EESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEDElcQKAFAPFLRFMYSNHVVLHKD 194
Cdd:cd18349     3 FNNELMADVHFIVGppgaSQRVPAHKYVLAVGSSVFYAMFYGDLAEVKSEIHIPDVE--PAAFLILLKYMYSDEIDLEAD 80

                          90       100
                  ....*....|....*....|....*....
gi 1254004679 195 NCLPLLVLADKYNVTTLKKVCLDFAQSEI 223
Cdd:cd18349    81 TVLATLYAAKKYIVPALAKACVNFLETSL 109

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in intracisternal A particle-promoted polypeptide (IPP); IPP, also called Kelch-like protein 27 (KLHL27) or actin-binding protein IPP, is an actin-binding protein that may play a role in organizing the actin cytoskeleton. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679 112 LCDMAKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMS---QKWNGDKFDLELVEDELcqkaFAPFLRFMYSNH 188
Cdd:cd18256     8 LAQLNKLRGQHEFCDVQLQVGMELFSVHRLVLAASSPYFAALFAggmSESSKDVVQIHGVEPDI----FHILLDFIYTGV 83

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1254004679 189 VVLHKDNCLPLLVLADKYNVTTLKKVCLDFAQSEILP 225
Cdd:cd18256    84 VEVTVSNVQELLVAADMLQLTEVVEICCEFLKGQLHP 120

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 10 (KLHL10); KLHL10 is a substrate-specific adaptor of a CUL3-based E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins specifically in the testis during spermatogenesis. Haploinsufficiency of Klhl10 causes infertility in male mice. KLHL10 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679 121 NAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDK---FDLELVEDELCQKafapFLRFMYSNHVVLHKDNCL 197
Cdd:cd18240    14 EGKLCDVVIRVNGVEFPAHRNILCACSPYFRALFTNGWNETEkkvYKIPGVSPEMMEL----IIEYAYTRTVPITAENVE 89

                          90       100
                  ....*....|....*....|....*...
gi 1254004679 198 PLLVLADKYNVTTLKKVCLDFAQSEILP 225
Cdd:cd18240    90 ELLPAADQFNIMGIVKACCDFLEDQLCP 117

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 2 (BTBD2); BTBD2 is a BTB-domain-containing Kelch-like protein that interacts with DNA topoisomerase 1 (Topo1), a key enzyme of cell survival. BTBD1 and BTBD2 colocalize to cytoplasmic bodies with the RBCC/tripartite motif protein, TRIM5delta. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679 116 AKFYNNAQFSDVNMKVGE----ESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEDElcQKAFAPFLRFMYSNHVVL 191
Cdd:cd18347    14 AFLFNNEVLSDVHFLVGKglgsQRIPAHRFVLAVGSAVFDAMFNGGMATTSTEIELPDVE--PAAFLALLKFLYSDEVQI 91

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1254004679 192 HKDNCLPLLVLADKYNVTTLKKVCLDFAQSEI 223
Cdd:cd18347    92 GPETVMTTLYTAKKYAVPALEAHCVEFLKKNL 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB and CNC homolog (BACH) proteins; This subfamily includes BACH1 (also called BTB-basic leucine zipper transcription factor 1), BACH2 (also called BTB-basic leucine zipper transcription factor 2), and similar proteins. They belong to the cap 'n' collar (CNC) and basic leucine zipper (bZIP) factor family. BACH1 is a heme-responsive transcriptional repressor of heme oxygenase (HO)-1. It represses genes involved in heme metabolism and oxidative stress response. BACH2 is a lymphoid-specific transcription factor with a prominent role in B-cell development. It is transcriptionally regulated by the BCR/ABL oncogene. It represses the anti-apoptotic factor heme oxygenase-1 (HO-1). Subfamily members contain a BTB domain and a basic leucine zipper (bZIP) domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679 126 DVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDkFDLELVEdELCQKAFAPFLRFMYSNHVVLHKDNCLPLLVLADK 205
Cdd:cd18955     3 DVTIVVEDQRFRAHRAVLAACSDYFLSRVVGQTDGD-LVITLPE-EVTVKGFEPLLQFAYTAKLLLSKENVLEVCRCAEF 80

                          90
                  ....*....|...
gi 1254004679 206 YNVTTLKKVCLDF 218
Cdd:cd18955    81 LGVHNIEKACFDF 93

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 35 (KLHL35); KLHL35 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. Significant differences in DNA methylation of the KLHL35 gene in abdominal aortic aneurysm (AAA) patients compared to non-AAA controls suggest a potential role in AAA pathology. Hypermethylation of the KLHL35 gene has also been associated with the development of hepatocellular carcinoma. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679 124 FSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEDeLCQKAFAPFLRFMYSNHVVLHKDNCLPLLVLA 203
Cdd:cd18265    23 FTDVVLLVDGKDFPCHRATLSANSAYFRAMFGGHLKESRQAVVEIQK-VSAAAMEVLLDYMYGGGLRIQEDNVESVLEAS 101

                          90       100
                  ....*....|....*....|..
gi 1254004679 204 DKYNVTTLKKVCLDFAQSEILP 225
Cdd:cd18265   102 DLLQVSKLREACVRFLEGQLHP 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2; The RCC1-related guanine nucleotide exchange factor (GEF) family includes RCC1 and BTB domain-containing proteins, RCBTB1 and RCBTB2, both of which are chromosome condensation regulator-like guanine nucleotide exchange factors. They contain an RCC1 repeat, a BTB domain, and a BACK domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679 114 DMAKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDkfDLELVE-DELCQKAFAPFLRFMYSNHVVLH 192
Cdd:cd18298     2 SLRKAFNDPRTSDLKFRVDGKYIYVHKAILKIRCEYFRSMFQSHWNED--DKNVIEiDQYSYPVYYAFLRYLYTDQVDLP 79

                          90       100
                  ....*....|....*....|....*.
gi 1254004679 193 KDNCLPLLVLADKYNVTTLKKVCLDF 218
Cdd:cd18298    80 PEDAIGLLDLANSYCEERLKKLCEDI 105

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Drosophila melanogaster protein roadkill and similar proteins; Drosophila melanogaster protein roadkill, also called Hh-induced MATH and BTB domain-containing protein (HIB), is a hedgehog-induced BTB protein that modulates hedgehog signaling by degrading Ci/Gli transcription factor. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679 114 DMAKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEDeLCQKAFAPFLRFMYSNHVVLHK 193
Cdd:cd18345     8 DLGLLFERSAFSDVTLCVGGREFQAHKAILAARSPVFNAMFEHEMEERKQNRVEITD-VDHEVMREMLRFIYTGKAPNLD 86

                          90       100
                  ....*....|....*....|..
gi 1254004679 194 DNCLPLLVLADKYNVTTLKKVC 215
Cdd:cd18345    87 KMADDLLAAADKYALERLKVMC 108

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in speckle-type POZ protein-like (SPOPL); SPOPL, also called HIB homolog 2 or Roadkill homolog 2, is a component of a cullin-RING-based BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complexes that mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The complexes may contain homodimeric SPOPL or the heterodimers formed by speckle-type POZ protein (SPOP) and SPOPL, which are less efficient than ubiquitin ligase complexes containing only SPOP. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679 114 DMAKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDK---FDLELVEDELcqkaFAPFLRFMYSN--- 187
Cdd:cd18343    11 DLGNLWENSRFTDCSLFVGGQEFKAHKSILAARSPVFNAMFEHEMEESKknrVEINDVDPEV----FKEMMRFIYTGkap 86

                          90       100
                  ....*....|....*....|....*...
gi 1254004679 188 HVVLHKDNclpLLVLADKYNVTTLKKVC 215
Cdd:cd18343    87 NLDKMADN---LLAAADKYALERLKVMC 111

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Ectoderm-neural cortex protein 1 (ENC-1); ENC-1 is also called Kelch-like protein 37 (KLHL37), nuclear matrix protein NRP/B, or p53-induced gene 10 protein. It is an actin-binding nuclear matrix protein that associates with p110(RB), and is involved in the regulation of neuronal process formation and in differentiation of neural crest cells. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679 124 FSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEDELCQKAFAPFLRFMYSNHVVLHKDNCLPLLVLA 203
Cdd:cd18267    40 FTDVLLHAGNRSFPCHRAVLAACSRYFEAMFSGGLKESQDSEVNFHDSIHPEVLELLLDYAYSSRVIINEENAESLLEAG 119

                          90       100
                  ....*....|....*....|..
gi 1254004679 204 DKYNVTTLKKVCLDFAQSEILP 225
Cdd:cd18267   120 DMLEFQDIRDACAEFLEKNLHP 141

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in BTB/POZ domain-containing protein 3 (BTBD3); BTBD3 is a BTB-domain-containing Kelch-like protein that controls dendrite orientation toward active axons in the mammalian neocortex. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679 116 AKFYNNAQFSDVNMKVG----EESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEDElcQKAFAPFLRFMYSNHVVL 191
Cdd:cd18348    13 AVMFNNDLMADIHFVVGppggTQRLPGHKYVLAVGSSVFHAMFYGELAEDKDEIRIPDVE--PAAFLAMLKYIYCDEIDL 90

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1254004679 192 HKDNCLPLLVLADKYNVTTLKKVCLDFAQSEI 223
Cdd:cd18348    91 AADTVLATLYAAKKYIVPHLARACVNFLETSL 122

second BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Rho-related BTB domain-containing proteins (RhoBTB); RhoBTB proteins constitute a subfamily of atypical members within the Rho family of small guanosine triphosphatases (GTPases), which is characterized by containing a GTPase domain (in most cases, non-functional) followed by a proline-rich region, a tandem of 2 BTB domains, and a conserved C-terminal region. In humans, the RhoBTB subfamily consists of 3 isoforms: RhoBTB1, RhoBTB2, and RhoBTB3. Orthologs are present in several other eukaryotes, such as Drosophila and Dictyostelium, but have been lost in plants and fungi. This model corresponds to the second BTB domain. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679 117 KFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSqkwnGDKFDLELVEDELCQKAFAPFLRFM---YSNHV-VLH 192
Cdd:cd18300     2 LFLNKGLFSDVTFIVEDGTIPAHKALLVARCDVMAAMFG----GNFRESSAKEVELPGVSKETFLALLeylYTDQApILE 77

                          90       100
                  ....*....|....*....|...
gi 1254004679 193 KDNCLPLLVLADKYNVTTLKKVC 215
Cdd:cd18300    78 DGDCVGLIVLANRLCLPRLVALC 100

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in plant BTB/POZ-MATH (BPM) protein family; The BPM protein family includes Arabidopsis thaliana BTB/POZ and MATH domain-containing proteins, AtBPM1-6, and similar proteins from other plants. BPM protein, also called protein BTB-POZ and MATH domain, may act as a substrate-specific adaptor of an E3 ubiquitin-protein ligase complex (CUL3-RBX1-BTB) which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679 114 DMAKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMM---SQKWNGDKFDLELVEdelcQKAFAPFLRFMYSNHVV 190
Cdd:cd18280     4 HFGALLESEEGADVTFNVDGEKFRAHKLVLAARSPVFRSMLfgpMREENEGEIVIEDVE----PPVFKALLHFIYKDELP 79

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1254004679 191 -LHKDNCLP-----------LLVLADKYNVTTLKKVC 215
Cdd:cd18280    80 dDVEPAGSDsssldttmaqhLLAAADRYALERLRLLC 116

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 25 (KLHL25); KLHL25, also called ectoderm-neural cortex protein 2 (ENC-2), is a substrate-specific adaptor of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that is required for translational homeostasis. The BCR(KLHL25) ubiquitin ligase complex acts by mediating ubiquitination of hypophosphorylated EIF4EBP1 (4E-BP1). Cullin3-KLHL25 ubiquitin ligase also targets ATP-citrate lyase (ACLY), a key enzyme for lipid synthesis, for degradation to inhibit lipid synthesis and tumor progression. KLHL25 contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679 124 FSDVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEDELCQKAFAPFLRFMYSNHVVLHKDNCLPLLVLA 203
Cdd:cd18254    22 FTDVTLWAGNRSFPCHRAVLAACSRYFEAMFSNGLRESLDSTVNFHDSLHPEVLELLLDFAYSSRIIINEENAESLLEAG 101

                          90       100
                  ....*....|....*....|..
gi 1254004679 204 DKYNVTTLKKVCLDFAQSEILP 225
Cdd:cd18254   102 DMLQFHDVRDAAAEFLEKNLYP 123

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 4 (KLHL4); KLHL4 shares high identity and similarity with the Drosophila kelch protein, a component of ring canals. It may be associated with X-linked cleft palate (CPX) and is also a candidate gene in the impairment of mullerian duct development. In addition, it has been identified as a target of insulin-like growth factor binding protein 5 (IGFBP5). KLHL4 contains a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679 110 ETLCDMAKFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMS---QKWNGDKFDLELVEDElcqkAFAPFLRFMYS 186
Cdd:cd18336     5 QTFRKMENYLQHKQLCDVLLIAGNLKIPAHRLVLSAVSDYFAAMFTndvREAKQEEIKMEGVDPD----ALKALVHYAYT 80

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 1254004679 187 NHVVLHKDNCLPLLVLADKYNVTTLKKVCLDFAQSEILP 225
Cdd:cd18336    81 GVLELKEDTIESLLAAACLLQLSQVIDVCCNFLMKQLHP 119

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 24 (KLHL24); KLHL24, also called kainate receptor-interacting protein for GluR6 (KRIP6) or protein DRE1, is necessary to maintain the balance between intermediate filament stability and degradation, a process that is essential for skin integrity. KLHL24 is a component of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex that mediates ubiquitination of KRT14 and controls its levels during keratinocyte differentiation. It contains a BTB domain and kelch repeats, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679 117 KFYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFDRMMSqkwNGDKFDLE-LVE-DELCQKAFAPFLRFMYSNHVVLHKD 194
Cdd:cd18253    11 EFRDSRLFTDVIICVEGREFPCHRAILSACSSYFRAMFC---NDHRESREmLVEiNGILAEAMDCFLQYVYTGKVKITTE 87

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1254004679 195 NCLPLLVLADKYNVTTLKKVCLDFAQSEILP 225
Cdd:cd18253    88 NVQYLFETSSLFQISPLRDACAKFLEEQLDP 118

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch repeat and BTB domain-containing protein 3 (KBTBD3); KBTBD3, also called BTB and kelch domain-containing protein 3 (BKLHD3), contains a BTB domain and kelch repeats, characteristics of a kelch family protein. Its function remains unclear. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679 118 FYNNAQFSDVNMKVGEESYPAHRLILSKSSDVFdRMMSQKWNGDKFDLELVEDELCQKAFAPFLRFMYSNHVVLHKDNCL 197
Cdd:cd18271    18 FREQNAFFDFNIIVKDETIPCHRCVLAACSDFF-RAMFEVNMKERDDGSVTISNLSPKAVKAFLDYAYTGKAEITDDNVE 96

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1254004679 198 PLLVLADKYNVTTLKKVCLDFaqseILPVIDL 229
Cdd:cd18271    97 MFFQMSSFLQVSLLSKACSDF----LIKSIDL 124

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like proteins KLHL1, KLHL4 and KLHL5; This family contains the Kelch-like proteins: KLHL1, KLHL4 and KLHL5, all of which share high identity and similarity with the Drosophila kelch protein, a component of ring canals. KLHL1 is a neuronal actin-binding protein that modulates voltage-gated CaV2.1 (P/Q-type) and CaV3.2 (alpha1H T-type) calcium channels. Family members contain a BTB domain and kelch repeat domains, characteristics of a kelch family protein. The BTB/POZ domain is a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679 125 SDVNMKVGEESYPAHRLILSKSSDVFDRMMSQkwngdkfDL-ELVEDELCQK-----AFAPFLRFMYSNHVVLHKDNCLP 198
Cdd:cd18234     2 CDVILIAGDRRIPAHRLVLSAVSDYFAAMFTN-------DVrEATEEEIKLKdvdpdALWTLVQYCYTGRLELKEDNVES 74

                          90       100
                  ....*....|....*....|
gi 1254004679 199 LLVLADKYNVTTLKKVCLDF 218
Cdd:cd18234    75 LLATACLLQLSEVVEACCGF 94

BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 32 (ZBTB32); ZBTB32 is also called FANCC-interacting protein, fanconi anemia zinc finger protein (FAZF), testis zinc finger protein (TZFP), or zinc finger protein 538 (ZNF538). It is a DNA-binding transcription factor that binds to the 5'-TGTACAGTGT-3' core sequence. It acts as a transcription suppressor that controls T cell-mediated autoimmunity. ZBTB32 is essential for down-regulation of GATA3 via ZPO2; this promotes aggressive breast cancer development. It contains a BTB/POZ domain, a common protein-protein interaction motif of about 100 amino acids.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1254004679 126 DVNMKVGEESYPAHRLILSKSSDVFDRMMSQKWNGDKFDLELVEdelcQKAFAPFLRFMYSNHVVLHKDNCLPLLVLADK 205
Cdd:cd18218    20 DTLITVGSQEFPAHSLVLAGASQQLGRQLTNPNPGQWCLGEGIS----PSTFKQLLDFVYGESVEVQPGELRPLLEAARA 95