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Conserved domains on  [gi|1255287556|ref|NP_001343908|]
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major facilitator superfamily domain-containing protein 10 isoform 1 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 52-434 5.68e-173

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17389:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 391  Bit Score: 490.63  E-value: 5.68e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  52 ERHGREQDPLYGSWQRG-VDWFASAIGMPAEKRYNSVLFGGLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAI 130
Cdd:cd17389    27 DYYGQNDDSGLYSLQISsVDWFRDAIGAPDERRYNSVLFGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAI 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 131 SYAVWATSRSFKAFLASRVIGGISKGNVNLSTAIVADLGSPPTRSQGMAVIGVAFSLAFTLGPMLGAFLSV--------- 201
Cdd:cd17389   107 SYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFASftrslgevf 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 202 -EMVPWISLLFAISDMLFIFCFLPETLPQEKRassvTLGFhtaahllsplallrfaavthsqdppaehrlrnlrrlglVY 280
Cdd:cd17389   187 fSMPALFALVLALADLLFIFFFLPETLPSNLR----RLGL--------------------------------------VY 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 281 FLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMATIQGTYARRISPGKEAAAVTRAMLLLVPAFLLIGWAHSL 360
Cdd:cd17389   225 FLYLFLFSGLEFTLTFLTHQRFQYTSMQQGKMFFFIGIIMALVQGGYVRRIKPGKEKKAVLQGLILLIPAFLLIGWASSV 304

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1255287556 361 PTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVAASVYWLTGAQVCFTVCSA 434
Cdd:cd17389   305 TVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVACTVYWLAGSEACYTIGAL 378
 
Name Accession Description Interval E-value
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 52-434 5.68e-173

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 490.63  E-value: 5.68e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  52 ERHGREQDPLYGSWQRG-VDWFASAIGMPAEKRYNSVLFGGLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAI 130
Cdd:cd17389    27 DYYGQNDDSGLYSLQISsVDWFRDAIGAPDERRYNSVLFGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAI 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 131 SYAVWATSRSFKAFLASRVIGGISKGNVNLSTAIVADLGSPPTRSQGMAVIGVAFSLAFTLGPMLGAFLSV--------- 201
Cdd:cd17389   107 SYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFASftrslgevf 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 202 -EMVPWISLLFAISDMLFIFCFLPETLPQEKRassvTLGFhtaahllsplallrfaavthsqdppaehrlrnlrrlglVY 280
Cdd:cd17389   187 fSMPALFALVLALADLLFIFFFLPETLPSNLR----RLGL--------------------------------------VY 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 281 FLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMATIQGTYARRISPGKEAAAVTRAMLLLVPAFLLIGWAHSL 360
Cdd:cd17389   225 FLYLFLFSGLEFTLTFLTHQRFQYTSMQQGKMFFFIGIIMALVQGGYVRRIKPGKEKKAVLQGLILLIPAFLLIGWASSV 304

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1255287556 361 PTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVAASVYWLTGAQVCFTVCSA 434
Cdd:cd17389   305 TVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVACTVYWLAGSEACYTIGAL 378
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
86-411 1.45e-25

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 106.98  E-value: 1.45e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  86 SVLFGGLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVN-LSTAI 164
Cdd:COG2814    43 SPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFpAALAL 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 165 VADLGSPPTRSQGMAVIGVAFSLAFTLGPMLGAFL----SVEMVPWISLLFAISDMLFIFCFLPETLPQEKRASSVTLgf 240
Cdd:COG2814   123 IADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLadlfGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL-- 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 241 htaAHLLSPLALLRFAAVThsqdppaehrlrnlrrlglvyFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTM 320
Cdd:COG2814   201 ---RELLRRPRLLLLLLLA---------------------FLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGG 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 321 ATIQGTYARRISPGKEAAAVTRAMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGI 400
Cdd:COG2814   257 VLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGL 336

                         330
                  ....*....|.
gi 1255287556 401 LRSLGALGRAL 411
Cdd:COG2814   337 YNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
86-413 6.15e-21

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 93.64  E-value: 6.15e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  86 SVLFGGLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVN-LSTAI 164
Cdd:pfam07690  30 SPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFpAALAL 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 165 VADLGSPPTRSQGMAVIGVAFSLAFTLGPMLGAFLSV----EMVPWISLLFAIsdMLFIFCFLPETLPQEKRASSVTLGF 240
Cdd:pfam07690 110 IADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASlfgwRAAFLILAILSL--LAAVLLLLPRPPPESKRPKPAEEAR 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 241 HTAAHLLSPLALLRFAAVThsqdppaehrlrnlrrlglVYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTM 320
Cdd:pfam07690 188 LSLIVAWKALLRDPVLWLL-------------------LALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLG 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 321 ATIQ---GTYARRISPGKEAAAVTRAMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTI 397
Cdd:pfam07690 249 AIGRlllGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTA 328

                         330
                  ....*....|....*.
gi 1255287556 398 MGILRSLGALGRALGP 413
Cdd:pfam07690 329 SGLYNTAGSLGGALGP 344
2_A_01_02 TIGR00880
Multidrug resistance protein;
91-226 5.06e-15

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 71.91  E-value: 5.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  91 GLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVNLST-AIVADLG 169
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGaALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1255287556 170 SPPTRSQGMAVIGVAFSLAFTLGPMLGAFLSV----EMVPWISLLFAISDMLFIFCFLPET 226
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQflgwRAPFLFLAILALAAFILLAFLLPET 141
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
97-232 9.11e-10

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 60.31  E-value: 9.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  97 FSLLQFFSAPLtgaaSDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGIS-KGNVNLSTAIVADLGSPPTRS 175
Cdd:PRK11102   39 FAIGQLFYGPM----ADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAaAAASVVINALMRDMFPKEEFS 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1255287556 176 QGMAVIGVAFSLAFTLGPMLGAFLSV----EMVPWISLLFAISDMLFIFCFLPETLPQEKR 232
Cdd:PRK11102  115 RMMSFVTLVMTIAPLLAPIIGGWLLVwfswHAIFWVLALAAILAAALVFFFIPETLPKERR 175
 
Name Accession Description Interval E-value
MFS_MFSD10 cd17389
Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily ...
 52-434 5.68e-173

Major facilitator superfamily domain-containing protein 10; Major facilitator superfamily domain-containing protein 10 (MFSD10) is also called tetracycline transporter-like protein (TETRAN). It is expressed in various human tissues, including the kidney. In cultured cells, its overexpression facilitated the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs). MFSD10/TETRAN overexpression cause resistance to some NSAIDs, suggesting that it may be an organic anion transporter that serves as an efflux pump for some NSAIDs and various other organic anions at the final excretion step. MFSD10 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340947 [Multi-domain]  Cd Length: 391  Bit Score: 490.63  E-value: 5.68e-173
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  52 ERHGREQDPLYGSWQRG-VDWFASAIGMPAEKRYNSVLFGGLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAI 130
Cdd:cd17389    27 DYYGQNDDSGLYSLQISsVDWFRDAIGAPDERRYNSVLFGGLIGSLFSLLQFLSSPITGAASDVYGRKPVLLLTMIGLAI 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 131 SYAVWATSRSFKAFLASRVIGGISKGNVNLSTAIVADLGSPPTRSQGMAVIGVAFSLAFTLGPMLGAFLSV--------- 201
Cdd:cd17389   107 SYALWAVSRSFTIFLLSRIVGGISKGNVSLSTAIVADVTSPKKRSKGMALIGVAFSLGFIIGPMIGAYFASftrslgevf 186

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 202 -EMVPWISLLFAISDMLFIFCFLPETLPQEKRassvTLGFhtaahllsplallrfaavthsqdppaehrlrnlrrlglVY 280
Cdd:cd17389   187 fSMPALFALVLALADLLFIFFFLPETLPSNLR----RLGL--------------------------------------VY 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 281 FLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMATIQGTYARRISPGKEAAAVTRAMLLLVPAFLLIGWAHSL 360
Cdd:cd17389   225 FLYLFLFSGLEFTLTFLTHQRFQYTSMQQGKMFFFIGIIMALVQGGYVRRIKPGKEKKAVLQGLILLIPAFLLIGWASSV 304

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1255287556 361 PTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVAASVYWLTGAQVCFTVCSA 434
Cdd:cd17389   305 TVLYAGLFLYSFAAATVVPCLTTLVSGYGSDDQKGTVMGIFRSLGALARALGPIVACTVYWLAGSEACYTIGAL 378
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 76-431 3.00e-57

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 192.41  E-value: 3.00e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  76 IGMPAEKRYNSVLFGGLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISK 155
Cdd:cd17330    22 YVREFNKLGASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSRNLWLLFLARFLDGLTG 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 156 GNVNLSTAIVADLGSPPTRSQGMAVIGVAFSLAFTLGPMLGAFLS----VEMVPWISLLFAISDMLFIFCFLPetlpqek 231
Cdd:cd17330   102 GNVSVAQAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLStpygYALPFLVAAALALLNLVLVLFFLP------- 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 232 rassvtlgfhtaahllsPLALLRFaavthsqdppaehrlrnlrrlglVYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGK 311
Cdd:cd17330   175 -----------------PLRRLLL-----------------------VYFLIALAFAGLESVFSLFLKDRFGFSPSQIGL 214

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 312 MFFFIGLTMATIQGTYARRISP-GKEAAAVTRAMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGS 390
Cdd:cd17330   215 LLALVGIAGILAQLLLIPRLAKrLGERKLLRLGLLLAIIGLLLLPFASSVPLLVLAAAILAFGTGIVFPALSALLSKSVP 294

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1255287556 391 PGQKGTIMGILRSLGALGRALGPVVAASVYWLTGAQVCFTV 431
Cdd:cd17330   295 SKEQGKAQGIIQSLQSLARIIGPLLAGPLYSFLGPGVPFLL 335
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 91-416 4.63e-31

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 122.34  E-value: 4.63e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  91 GLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVNLSTAIVADLGS 170
Cdd:cd17390    34 GLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSLALLFLSRIPLGIFKHTQSLCKAYLSDLVS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 171 PPTRSQGMAVIGVAFSLAFTLGPMLGAFLsVEMVPWISLLFAISDMLFIFCflpetlpqekrassvtlgfhtaahllspl 250
Cdd:cd17390   114 EQERSRVLGRFNAASSLGFILGPVVGGHL-AETDGGFYYVALLCSAIFILN----------------------------- 163

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 251 ALLRFAAVTHSQDppaehrlrnlrrLGLVYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLtMATIQGTYARR 330
Cdd:cd17390   164 AGLVWFLLSKLWD------------LLLVRFLMGFSVLLFRSNFSLYLEERFDLSPKTIGYLISYSGV-LGALSGFLVGR 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 331 IS---PGKEAAAVTRAMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGAL 407
Cdd:cd17390   231 ILklyKNNEYLLLLHSFILLALSLLGLALAPSIWLLVLCLTPLSISSAVLRTCSTSLLLSRGKSKERGTLLGVGQSVTSL 310


                  ....*....
gi 1255287556 408 GRALGPVVA 416
Cdd:cd17390   311 ARILAPLLS 319
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 86-434 7.79e-31

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 122.30  E-value: 7.79e-31
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  86 SVLFGGLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKG-NVNLSTAI 164
Cdd:cd17325    29 SVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATSYWQLLLARFLQGLASAaVWPAAMAL 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 165 VADLGSPPTRSQGMAVIGVAFSLAFTLGPMLGAFL----SVEMVPWISLLFAISDMLFIFCFLPETLPQEKRASSVTLGF 240
Cdd:cd17325   109 IADIAPPEERGRAMGIFSSAIGLGFLIGPLLGGLLadalGYRAPFLVCAALALLALVLALLLLPEPRPPPNKRAVSAARL 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 241 HTAAHLLSPLALLRFAAVthsqdppaehrlrnlrrlglVYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTM 320
Cdd:cd17325   189 RSGLRLLLRDRRLLALFL--------------------AIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLAS 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 321 ATIQGTYARRISPGKEAAAVTRAMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGI 400
Cdd:cd17325   249 ALSQPPAGKLSDRIGRKPLILIGLLLSAVALLLLPLATSFWLLLLLLALLGLGLGLVFPATLALLADIVPPEGRGTAMGL 328

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1255287556 401 LRSLGALGRALGPVVAASVYWLTGAQVCFTVCSA 434
Cdd:cd17325   329 FNTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAA 362
MFS_TetA cd17388
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ...
 89-425 1.93e-30

Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340946 [Multi-domain]  Cd Length: 385  Bit Score: 121.20  E-value: 1.93e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  89 FGGLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVNLSTAIVADL 168
Cdd:cd17388    39 HYGVLLALYALMQFIFAPILGALSDRFGRRPVLLLSLAGAALDYLLMAFAPTLWWLYLGRIIAGITGATGAVAAAYIADV 118

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 169 GSPPTRSQGMAVIGVAFSLAFTLGPMLGAFL---SVEMVPWISLLFAISDMLFIFCFLPETLPQEKRassvTLGFHTAAH 245
Cdd:cd17388   119 TPPEQRARNFGLLGAAFGLGFIAGPALGGLLgeiSPRAPFLVAAGLNGLNFLLGLFVLPESLPPERR----RAFRWRRAN 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 246 LLSPLALLRFaavthsqdppaehrLRNLRRLGLVYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMATIQG 325
Cdd:cd17388   195 PFGSLRWLTG--------------FPGLLGLLAVFFLIQLIGQVPATTWVLFTEDRFDWSPTMVGLSLAVFGLLHALFQA 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 326 TYARRISPG-KEAAAVTRAMLLLVPAFLLIGWAHSLPTLGLGLMLYSfAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSL 404
Cdd:cd17388   261 FVTGPIAKRlGEKRAILLGLAADALGFLLLAFATQGWMVFPILILLA-LGGIAGPALQGLLSRQVPENEQGELQGVLTSL 339

                         330       340
                  ....*....|....*....|.
gi 1255287556 405 GALGRALGPVVAASVYWLTGA 425
Cdd:cd17388   340 TSLTSIIGPLLFTGIFAASPA 360
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 91-434 5.98e-28

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 114.20  E-value: 5.98e-28
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  91 GLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGI-SKGNVNLSTAIVADLG 169
Cdd:cd17474    37 GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAGRALQGIgAAGLGPLALTLIGDLF 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 170 SPPTRSQGMAVIGVAFSLAFTLGPMLGAFLSveMVPW-----ISLLFAISDMLFIFCFLPETLPQEKRASSVTLGfhTAA 244
Cdd:cd17474   117 EGGERAKAMGLYEAALGLGIAVGPLLGGLLA--AISWrypffLLAALIPVAFLAILFLLPEPKEKAKSSSATKLR--DLK 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 245 HLLSPLALLRFAAVThsqdppaehrlrnlrrlglvyFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMATIQ 324
Cdd:cd17474   193 KALRGRGLLTFLVSA---------------------FLYFFLYFAFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGS 251

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 325 GTYARRISPGKEAAAVTR-AMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRS 403
Cdd:cd17474   252 LFVGRLLKKRFGARRILViGLLLYALSLLLLGFVPSLALLLIAIVLFGLGLGLNLPLLTTLVTELAPEEERGTASSLYNF 331

                         330       340       350
                  ....*....|....*....|....*....|.
gi 1255287556 404 LGALGRALGPVVAASVYWLTGAQVCFTVCSA 434
Cdd:cd17474   332 VRFLGQAVGPLLFGLLLEIFGLSAPFLVGAA 362
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
86-411 1.45e-25

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 106.98  E-value: 1.45e-25
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  86 SVLFGGLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVN-LSTAI 164
Cdd:COG2814    43 SPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFpAALAL 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 165 VADLGSPPTRSQGMAVIGVAFSLAFTLGPMLGAFL----SVEMVPWISLLFAISDMLFIFCFLPETLPQEKRASSVTLgf 240
Cdd:COG2814   123 IADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLadlfGWRWVFLVNAVLALLALLLLLRLLPESRPAARARLRGSL-- 200

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 241 htaAHLLSPLALLRFAAVThsqdppaehrlrnlrrlglvyFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTM 320
Cdd:COG2814   201 ---RELLRRPRLLLLLLLA---------------------FLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGG 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 321 ATIQGTYARRISPGKEAAAVTRAMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGI 400
Cdd:COG2814   257 VLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLALAGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRASGL 336

                         330
                  ....*....|.
gi 1255287556 401 LRSLGALGRAL 411
Cdd:COG2814   337 YNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
86-413 6.15e-21

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 93.64  E-value: 6.15e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  86 SVLFGGLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVN-LSTAI 164
Cdd:pfam07690  30 SPTEIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLWLLLVLRVLQGLGAGALFpAALAL 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 165 VADLGSPPTRSQGMAVIGVAFSLAFTLGPMLGAFLSV----EMVPWISLLFAIsdMLFIFCFLPETLPQEKRASSVTLGF 240
Cdd:pfam07690 110 IADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASlfgwRAAFLILAILSL--LAAVLLLLPRPPPESKRPKPAEEAR 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 241 HTAAHLLSPLALLRFAAVThsqdppaehrlrnlrrlglVYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTM 320
Cdd:pfam07690 188 LSLIVAWKALLRDPVLWLL-------------------LALLLFGFAFFGLLTYLPLYQEVLGLSALLAGLLLGLGGLLG 248

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 321 ATIQ---GTYARRISPGKEAAAVTRAMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTI 397
Cdd:pfam07690 249 AIGRlllGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTA 328

                         330
                  ....*....|....*.
gi 1255287556 398 MGILRSLGALGRALGP 413
Cdd:pfam07690 329 SGLYNTAGSLGGALGP 344
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 91-432 1.09e-19

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 90.30  E-value: 1.09e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  91 GLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNV-NLSTAIVADLG 169
Cdd:cd17324    37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALAPSFALLLLARALAGLAHGGFwAIAAAYAADLV 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 170 SPPTRSQGMAVIGVAFSLAFTLGPMLGAFLSVE----MVPWISLLFAISDMLFIFCFLPETLPQEKRASSVTLGFhtAAH 245
Cdd:cd17324   117 PPEKRGRAIGLVFSGLTLGLVLGRPLGGLLGQLlgwrAAFLAIAVLALLAALLLWRLLPSLPPKKPGSLGLLSSL--LLL 194

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 246 LLSPLALLRFAAVthsqdppaehrlrnlrrlglvyFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMA---T 322
Cdd:cd17324   195 LRNPRLRLAYLIT----------------------FLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVvgsP 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 323 IQGTYARRISPGKEAAAvtrAMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYgSPGQKGTIMGILR 402
Cdd:cd17324   253 LAGRLADRGGRRALLIA---LLLLAAALLLLTLLGPSPLLLLVGLVLWGLGFFAAHSALQTRVLRL-APEARGLASSLYL 328

                         330       340       350
                  ....*....|....*....|....*....|
gi 1255287556 403 SLGALGRALGPVVAASVYWLTGAQVCFTVC 432
Cdd:cd17324   329 AAYNLGGALGAALGGLVLDHGGWAGVGWVG 358
MFS_MdfA_MDR_like cd17320
Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major ...
 96-420 4.82e-16

Multidrug transporter MdfA and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as MdfA (also called chloramphenicol resistance pump Cmr), EmrD, MdtM, MdtL, bicyclomycin resistance protein (also called sulfonamide resistance protein), and the uncharacterized inner membrane transport protein YdhC. EmrD is a proton-dependent secondary transporter, first identified as an efflux pump for uncouplers of oxidative phosphorylation. It expels a range of drug molecules and amphipathic compounds across the inner membrane of E. coli. Similarly, MdfA is a secondary multidrug transporter that exports a broad spectrum of structurally and electrically dissimilar toxic compounds. These MDR transporters are drug/H+ antiporters (DHA) belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340878 [Multi-domain]  Cd Length: 379  Bit Score: 79.54  E-value: 4.82e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  96 AFSLLQFFSAPLtgaaSDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGN-VNLSTAIVADLGSPPTR 174
Cdd:cd17320    46 GFALGQLLYGPL----SDRFGRRPVLLAGLLLFILASLLCALASSIEQLLIARFLQGLGAAAgSVVARAIVRDLYSGAEL 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 175 SQGMAVIGVAFSLAFTLGPMLGAFLSVEM----VPWISLLFAISDMLFIFCFLPETLPQEKRASSVTLGFHTAAHLLSPL 250
Cdd:cd17320   122 AKIFSLLMMILAIAPALAPLLGGLLLLFFgwraIFVFLALLGLLLLLLVLLFLPETLPEEKRKPLLSSLLRAYKRVLKNR 201

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 251 ALLRFAAVThsqdppaehrlrnlRRLGLVYFLYLFlfsgleyTLSFLAHQRFQFSSLQQGKMFFFIGLTM---ATIQGTY 327
Cdd:cd17320   202 RFLGYALAL--------------GLSFAGLFAYLA-------AAPFIYIEQLGLSPAQFGLLFALNAIALilgSLLNGRL 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 328 ARRISPGK--EAAAVTRAMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSyGSPGQKGTIMGILRSLG 405
Cdd:cd17320   261 VRRFGPRRllRLGLLLLLAAALVLLLAALLGGLSLWPLVAPLFLIFFGFGLIFPNATSLALE-PFPHVAGTASALLGFLQ 339

                         330
                  ....*....|....*
gi 1255287556 406 ALGRALGPVVAASVY 420
Cdd:cd17320   340 FLIGALAGALVGLLP 354
2_A_01_02 TIGR00880
Multidrug resistance protein;
91-226 5.06e-15

Multidrug resistance protein;


Pssm-ID: 273318 [Multi-domain]  Cd Length: 141  Bit Score: 71.91  E-value: 5.06e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  91 GLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVNLST-AIVADLG 169
Cdd:TIGR00880   1 GLLLAGYALGQLIYSPLSGLLTDRFGRKPVLLVGLFIFVLSTAMFALSSNITVLIIARFLQGFGAAFALVAGaALIADIY 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1255287556 170 SPPTRSQGMAVIGVAFSLAFTLGPMLGAFLSV----EMVPWISLLFAISDMLFIFCFLPET 226
Cdd:TIGR00880  81 PPEERGVALGLMSAGIALGPLLGPPLGGVLAQflgwRAPFLFLAILALAAFILLAFLLPET 141
MFS_arabinose_efflux_permease_like cd17473
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ...
 85-424 9.60e-15

Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341026 [Multi-domain]  Cd Length: 374  Bit Score: 75.30  E-value: 9.60e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  85 NSVLFGGLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVN-LSTA 163
Cdd:cd17473    32 NSELLVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLYALLASRALLGIGVAGIMtLATA 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 164 IVADLGSPPTRSQGMAVIGVAFSLAFTLGPMLGAFLsVEM---VPWISLLFAISDMLFIFCFLPETLPQEKRASSVTLgf 240
Cdd:cd17473   112 LIGDYFEGEERAKMLGLQSAAMSLGGVVFLLLGGAL-AEIgwrAPFLVYLLALPVLILVLLFLPEPARKSKSAASPGA-- 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 241 hTAAHLLSPLALLRFAAVThsqdppaehrlrnlrrlglvyFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTM 320
Cdd:cd17473   189 -ATAAALPWKRVLPIYFLA---------------------FLAMLLFYVIPIQLPFLLQERGGGSAALIGLALAIASLAG 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 321 ATIQGTYARRISPGKEAAAVTRAMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGI 400
Cdd:cd17473   247 AIGALLFGRLKRRLGKRRLLAIGFALMALGFLLLALASGLWVVLLGAILAGLGFGLLLPTLNSWAMSLVPPELRGRAMGI 326

                         330       340
                  ....*....|....*....|....
gi 1255287556 401 LRSLGALGRALGPVVAASVYWLTG 424
Cdd:cd17473   327 VTSAFFLGQFLSPLVLGPLVNLTG 350
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 26-434 9.64e-15

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 75.34  E-value: 9.64e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  26 IIVLFLGllldllaftlllpllpgllerhgreqdplygswqRGVDWFASAIGMP------AEKRYNSVLFGGLIGSAFSL 99
Cdd:cd17329     1 LWVLLIG----------------------------------SFLNRLGFFMVWPfmaiylHQQLGLSASIVGLVLALSAV 46

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 100 LQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVN-LSTAIVADLGSPPTRSQGM 178
Cdd:cd17329    47 AGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSPWLFAIALVLTGFGGGLFEpASEAMIADVTTPENRTRAF 126

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 179 AVIGVAFSLAFTLGPMLGAFLSVEMVPWISLLFAIsdMLFIFCFLPETLPQEKRAssvtlgFHTAAHLLSPLALLRFAAv 258
Cdd:cd17329   127 SLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAV--LFLLAALVLLFLLPETRP------KRRAAEKTEILRGYKIVL- 197

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 259 thsQDPPaehrlrnLRRLGLVYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMATIQGTYARRISPGKEAA 338
Cdd:cd17329   198 ---RDRA-------FLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFRLRK 267

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 339 AVTRAMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVAAS 418
Cdd:cd17329   268 ILMIGILLFAIGFAVLAFANTLAVLILAMIVLTLGEMLVFPAVQTLVAALAPPDKRGSYMGFYALAWGLGRAIGPLVGGL 347

                         410
                  ....*....|....*.
gi 1255287556 419 VYWLTGAQVCFTVCSA 434
Cdd:cd17329   348 LLDLLGPGLPWLILAA 363
MFS_SLC22A18 cd17331
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ...
 85-420 1.75e-14

Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340889 [Multi-domain]  Cd Length: 382  Bit Score: 74.56  E-value: 1.75e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  85 NSVLFGGLIgSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRvIGGISKGNVNLSTAI 164
Cdd:cd17331    33 DSVVFGYLQ-TTFSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVPMLFLSR-LPSVFMHAMQAAQMV 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 165 VADLGSPPTRSQGMAVIGVAFSLAFTLGPMLGAFLSVEMVPWISLLFA----ISDMLFIFCFLPE-TLPQEKRASSVTLG 239
Cdd:cd17331   111 VTDLTDPGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAavgsLLSIVLVILLIPSnTKSKREKEAKESAS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 240 FHTAAHLLSPLALLRFAAVthsqdppaehrlrnlRRLGLVYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLT 319
Cdd:cd17331   191 PPSVFNLKEILRLLRLPGV---------------AFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTPEENGYLMSYAGVL 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 320 MATIQGTYARR-ISPGKEAAAVTRAMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIM 398
Cdd:cd17331   256 GMVVQGLLVGPlTKRFGERSLLKLSVALLAIGYLLLAFVTTVWQLLVLLLPLVIGGSVLYTVITSLLTKAVPPEDTGTAL 335

                         330       340
                  ....*....|....*....|..
gi 1255287556 399 GILRSLGALGRALGPVVAASVY 420
Cdd:cd17331   336 GLSHALFSLVRTVSPTIGGALL 357
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 91-429 3.44e-14

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 73.78  E-value: 3.44e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  91 GLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVNLST-AIVADLG 169
Cdd:cd17489    34 GLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATSVALLLVLRLIHGIGWGAFTTAAaTLVADII 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 170 SPPTRSQGMAVIGVAFSLAFTLGPMLGAFL----SVEMVPWISLLFAIsdMLFIFCFL----PETLPQEKRASSVTLGFH 241
Cdd:cd17489   114 PPSRRGEGIGYYGLATTLAMALGPALGLFLyqhlGFAVLFIVAAVLAL--LALLLVFLvkdpPPVAAEEAEAGTRAFRRL 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 242 TAAHLLSPLALLRFAAVTHSqdppaehrlrnlrrlGLVYFLYLFLFSGLeytlsflahqrfqfssLQQGKMFFFIGLTMA 321
Cdd:cd17489   192 VEKKVLPPALILFLASIAYG---------------AISTFLPLYAAERG----------------ISNAGLFFTVYAIAL 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 322 TIQGTYARRISPGK-EAAAVTRAMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGI 400
Cdd:cd17489   241 LLSRPFSGKLSDRKgPKTVIIPGLLLLALGLLLLSFAGSPWMLLLAAVLYGLGFGLLFPALQALAVDLVPPHRRGAANGT 320

                         330       340
                  ....*....|....*....|....*....
gi 1255287556 401 LRSLGALGRALGPVVAASVYWLTGAQVCF 429
Cdd:cd17489   321 FFIFFDLGIGLGGLLLGLVAELFGYRAMF 349
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
91-434 3.18e-13

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 70.67  E-value: 3.18e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  91 GLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVNLS-TAIVADLG 169
Cdd:COG2271    48 GLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSFWQLLLLRFLLGLGEAGFFPAaLKLIAEWF 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 170 SPPTRSQGMAVIGVAFSLAFTLGPMLGAFLsVEMVPWISLLFAISdmlfIFCFLpetlpqekrassvtlgfhtaahllsp 249
Cdd:COG2271   128 PPKERGRALGIFNAGGPLGGALAPPLLGWL-LAAFGWRAAFLILG----LPGLL-------------------------- 176

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 250 LALLRFAAVThsqdppaehrlrnlrrlgLVYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMATIQ---GT 326
Cdd:COG2271   177 LALLRFWLLA------------------LAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSllgGW 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 327 YARRISPGKEAAAVTrAMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGA 406
Cdd:COG2271   239 LSDRLGRRRKLVLAI-GLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAAELFPKKARGTASGLVNTFGF 317

                         330       340
                  ....*....|....*....|....*...
gi 1255287556 407 LGRALGPVVAASVYWLTGAQVCFTVCSA 434
Cdd:COG2271   318 LGGALGPLLVGYLLDATGYQAAFLLLAA 345
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 91-420 1.55e-12

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 68.61  E-value: 1.55e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  91 GLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVNLST-AIVADLG 169
Cdd:cd06174    34 GLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFWLLLLGRFLLGLGSGLIDPAVlALIADLF 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 170 SPPTRSQGMAVIGVAFSLAFTLGPMLGAFLSVEMVPWISLLFAISDMLFIFCFLPETLPQEKRASSVTLGFHTAAHLLSP 249
Cdd:cd06174   114 PERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKNEEASSKSVL 193

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 250 LALLRfaavtHSQDPPAehrlrnlRRLGLVYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMATIQGTYAR 329
Cdd:cd06174   194 KLLKR-----VLKNPGL-------WLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGL 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 330 RISPGKEAAAVTRAMLLLVPAFLLIGWAHSLPTLGLGLM-LYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALG 408
Cdd:cd06174   262 LSDRLIGRKPLLLIGLLLMALGLALLLLAPSLLLLLLLLlLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLG 341

                         330
                  ....*....|..
gi 1255287556 409 RALGPVVAASVY 420
Cdd:cd06174   342 GAIGPLLAGFLL 353
MFS_YajR_like cd17472
Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux ...
 92-432 5.60e-12

Escherichia coli inner membrane transport protein YajR and similar multidrug-efflux transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli inner membrane transport protein YajR and some uncharacterized multidrug-efflux transporters. YajR is a putative proton-driven major facilitator superfamily (MFS) transporter found in many gram-negative bacteria. Unlike most MFS transporters, YajR contains a C-terminal, cytosolic YAM domain, which may play an essential role for the proper functioning of the transporter. YajR-like transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341025 [Multi-domain]  Cd Length: 371  Bit Score: 66.86  E-value: 5.60e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  92 LIGSA---FSLLQ-FFSAPLtGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGIskGNVNLS-TAIVA 166
Cdd:cd17472    33 LIGLAlgiYGLTQaIFQIPF-GLLSDRIGRKPVILFGLLLFIAGSLLAAYATSIYGLILGRALQGS--GAISSVvMALLA 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 167 DLGSPPTRSQGMA----VIGVAFSLAFTLGPMLGAFLSVEMVPWISLLFAISDMLFIFCFLPEtlPQEKRASSVTLGFHT 242
Cdd:cd17472   110 DLTREENRTKAMAligaSIGIAFAISMVLGPLLAAHLGVSGLFLITAILSLVSLLILLFFVPD--PPKIVQISEKEKKKL 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 243 AAHLLSPlALLRFAAVthsqdppaehrlrnlrrlglVYFLYLFLFSGLeYTLSFLAHQRFqFSSLQQGKMF---FFIGLT 319
Cdd:cd17472   188 KKLLKNK-RLLRLDFS--------------------IFILHFVLMAFF-YILPLLLTQLG-GGKGQLWKVYlpaILIGFI 244

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 320 MATIQGTYARRISPGKeAAAVTRAMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMG 399
Cdd:cd17472   245 LMVPFVIYAEKKGKMK-QVFVSSILLIAVGFLLLLFAATSLWLLIIGLIIFFIGFNLLEALLPSLVSKIAPKEYRGTAMG 323

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1255287556 400 ILRSLGALGRALGPVVAASVYWLTGAQVCFTVC 432
Cdd:cd17472   324 IYNTSQFLGSFLGGALGGLLWGLLGYSSVFLTI 356
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 85-434 2.22e-11

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 65.33  E-value: 2.22e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  85 NSVLFGGLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKA------FLASRVIGGISKGNV 158
Cdd:cd06173    31 GSALLVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSlslwllLVLAFLLGIASAFFG 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 159 NLSTAIVADLGSPPTRSQGMAVIGVAFSLAFTLGPMLG----AFLSVEMVPWI-SLLFAISDMLFIFCFLPETLPQEKRA 233
Cdd:cd06173   111 PARQALLPELVPKEQLVRANALNSLATQLARIIGPALGgllvALLGPGGAFAInALSFLLSALLLLFIRRPPPAAPGESS 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 234 SSVTLGFHTAAHLLSPLALLRFAAVThsqdppaehrlrnlrrlglvYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMF 313
Cdd:cd06173   191 SLLLRDLREGLRYLRRSPLLRLLLLA--------------------LALFALLGGALTVLLPLLAKEVLGGGAAGYGLLL 250

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 314 FFIGLTMATIQGTYARRISPGKEAAAVTRAMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQ 393
Cdd:cd06173   251 AAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSPSLWLLLAALFLLGLAGGLFNVPLNTLLQLRVPDEL 330

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|.
gi 1255287556 394 KGTIMGILRSLGALGRALGPVVAASVYWLTGAQVCFTVCSA 434
Cdd:cd06173   331 RGRVFSVYNALNSGAMPLGALLAGLLADALGLSAVFLLAGA 371
MFS_MFSD14 cd17387
Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of ...
 85-422 2.97e-11

Major facilitator superfamily domain-containing 14A and 14B; This subfamily is composed of major facilitator superfamily domain-containing 14A (MFSD14A) and MFSD14B, and similar proteins. MFSD14A and MFSD14B are also called hippocampus abundant transcript 1 protein (HIAT1) and hippocampus abundant transcript-like protein 1 (HIATL1), respectively. They are both ubiquitously expressed with HIAT1 highly expressed intestis and HIATL1 most abundantly expressed in skeletal muscle. Gene disruption of MFSD14A causes globozoospermia and infertility in male mice. It has bee suggested that MFSD14A may transport a solute from the bloodstream that is required for spermiogenesis. The function of MFSD14B is unknown. The MFSD14 subfamily belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340945 [Multi-domain]  Cd Length: 410  Bit Score: 65.13  E-value: 2.97e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  85 NSVLFGGLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMlsLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVNLSTAI 164
Cdd:cd17387    33 HTFLMNGLVQGVKGILSFLSAPLIGALSDVWGRKSFLL--LTVFFTCAPIPLMRISPWWYFAMISVSGIFSVTFSVIFAY 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 165 VADLGSPPTRSQGMAVIGVAFSLAFTLGPMLGAFLS----VEMVPWISLLFAISDMLFIFCFLPETLPQEKRasSVTLGF 240
Cdd:cd17387   111 VADITTEEERSTAYGLVSATFAASLVTSPALGAYLSesygDNLVVLVATIVALLDICFILLAVPESLPEKMR--PASWGA 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 241 HTAAHLLSPLALLRFAAvthsQDPpaehrlrNLRRLGLVYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTM 320
Cdd:cd17387   189 PISWEQADPFASLRKVG----KDK-------TVLLICITVFLSYLPEAGQYSSFFVYLKQVMGFEYEEVAAFIAVVGILS 257

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 321 ATIQ---GTYARRISPGKEAAAVTRAMLLLVPAFLLIGWAHSLPTLGLGLMLYSfaaAVVVPGLSTMVSSYGSPGQKGTI 397
Cdd:cd17387   258 ITAQtllLSILMRSIGAKNTILLGLGFQMLQLAWYGFGSQHWMMWAAGAVAAMS---SITFPAISALVSRYADPDQQGAV 334

                         330       340
                  ....*....|....*....|....*
gi 1255287556 398 MGILRSLGALGRALGPVVAASVYWL 422
Cdd:cd17387   335 QGMITGIRGLCNGLGPALFGFVFYL 359
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
91-431 4.13e-11

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 64.49  E-value: 4.13e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  91 GLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVNLS-TAIVADLG 169
Cdd:COG0738    46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYPLLLLALFLLGLGLGLLDVAaNPYVAALG 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 170 sPPTRSQGMAVIGVAFSLAFTLGPMLGAFLS--------VEMVPWISLLFAISDMLFIFCFLPETLPQEKRASSVTLGFH 241
Cdd:COG0738   126 -PETAASRLNLLHAFFSLGALLGPLLGGLLIllglslswHLPYLILAVLLLLLALLFLRSKLPEIEEEEEEAAGSAASLK 204

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 242 TAahLLSPLALLRFAAVthsqdppaehrlrnlrrlglvyFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMF--FFIGLT 319
Cdd:COG0738   205 SL--LKNPRLLLGGLAI----------------------FLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLslFWGGMT 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 320 MATIQGTY-ARRISPGKeaaAVTRAMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSyGSPGQKGTIM 398
Cdd:COG0738   261 IGRFLGGFlLKRFGPVR---LLRLSALLAAVGLLLALLAPGPWLALIGLALVGLGLSLMFPTIFSLALD-GLGKRTAAAV 336

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1255287556 399 GILRSLGALGRALGPVVAASVYWLTGAQVCFTV 431
Cdd:COG0738   337 SAVLIMGIVGGAIGPPLIGFLADAFGLRAAFLV 369
MFS_MFSD8 cd17326
Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) ...
 89-434 2.27e-10

Major facilitator superfamily domain-containing protein 8; Major facilitator superfamily (MFS) domain-containing protein 8 (MFSD8) is also called ceroid-lipofuscinosis neuronal protein 7 (CLN7). It is a polytopic lysosomal membrane protein that may transport small solutes by using chemiosmotic ion gradients. Mutations in MFSD8/CLN7 cause a variant of late-infantile neuronal ceroid lipofuscinoses (vLINCL), a neurodegenerative lysosomal storage disorder. Some variants are associated with nonsyndromic autosomal recessive macular dystrophy. MFSD8/CLN7 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340884 [Multi-domain]  Cd Length: 374  Bit Score: 61.84  E-value: 2.27e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  89 FGGLIGSAFSLLQFFSAPLTGAASDYLG-RRPVMMLSLTGLAISYAVWATSRSFKAF-----LASRVIGGISKGNVNLST 162
Cdd:cd17326    37 FFGWVVAAYSLGQLVFSPVFGYWSNKTSsVKEPLIVSILIAIVGNILYALAEYFPSNrkyvmLVARFLIGVGAGNVAVLR 116

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 163 AIVADLGSPPTRSQGMAVIGVAFSLAFTLGPMLGAFLS-------VEMVP----------WISLLFAISDMLFIFCFLPE 225
Cdd:cd17326   117 AYVAAASTLKDRTRAMAVISAAQALGFIVGPALQAAFTpigypgyVIGIKlrfnmytapaWLMAILGIINIILILFFFKE 196

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 226 TLpqekrassvtlgfhtaahllspLALLRFAAvthsqdppaehrlrnlrrlglvyflyLFLFSGLEYTLSFLAHQRFQFS 305
Cdd:cd17326   197 VV----------------------CIFLFFVV--------------------------LFIFANLETIGTPLTMDMYGWT 228

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 306 S----LQQGKMFFFIGLTMATIQGTYA--RRISPGKeaaavtRAMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVP 379
Cdd:cd17326   229 ReeavLYNGIILAVSGVLSVLVFLLFKflSLGLIDE------RKILLGGLILFFLGFVVTLPWGITGVILFGLGYPIGNV 302

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1255287556 380 GLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVAASVYWLTGAQVCFTVCSA 434
Cdd:cd17326   303 MLYTLYSKILGPKPQGTMQGVLTASGSLARTLGPIFVTAIYTHFGPRWTWIITLG 357
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
91-434 2.93e-10

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 61.82  E-value: 2.93e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  91 GLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVNLSTAIVADLGS 170
Cdd:COG2223    43 GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWF 122

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 171 PPTRsQGMAV------IGVAFSLAFTLGPMLGAFLSVEMVPWISLLFAISDMLFIFCFLPEtlPQEKRASSVTLGFHTAA 244
Cdd:COG2223   123 PPDR-RGLALglaaggGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLRD--PPAGAAAAAKASLRDQL 199

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 245 HLLSPLALLRFAAvthsqdppaehrlrnlrrlglVYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMATIQ 324
Cdd:COG2223   200 EALRDPRFWLLSL---------------------LYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGR 258

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 325 ---GTYARRISPGKEAAAVtrAMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGIL 401
Cdd:COG2223   259 plgGWLSDRIGGRRVLLIV--FALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNGAVFALVPDIFPTKNAGAVYGLV 336

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1255287556 402 RSLGALGRALGPVVAASVYWLTGA-QVCFTVCSA 434
Cdd:COG2223   337 GAAGGLGGFLGPLLFGALLDATGSyTAAFLVFAV 370
PRK11102 PRK11102
Bcr/CflA family multidrug efflux MFS transporter;
97-232 9.11e-10

Bcr/CflA family multidrug efflux MFS transporter;


Pssm-ID: 182964 [Multi-domain]  Cd Length: 377  Bit Score: 60.31  E-value: 9.11e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  97 FSLLQFFSAPLtgaaSDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGIS-KGNVNLSTAIVADLGSPPTRS 175
Cdd:PRK11102   39 FAIGQLFYGPM----ADSFGRKPVILGGTLVFALAAVACALAQTIDQLIYMRFLHGLAaAAASVVINALMRDMFPKEEFS 114

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1255287556 176 QGMAVIGVAFSLAFTLGPMLGAFLSV----EMVPWISLLFAISDMLFIFCFLPETLPQEKR 232
Cdd:PRK11102  115 RMMSFVTLVMTIAPLLAPIIGGWLLVwfswHAIFWVLALAAILAAALVFFFIPETLPKERR 175
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 91-200 1.05e-08

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 56.80  E-value: 1.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  91 GLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVN-LSTAIVADLG 169
Cdd:cd17502    33 SWVGTAYLLTSTAFQPIYGKLSDLFGRKWVLLIAIVIFELGSLLCGLAPNMTMLIVGRAIQGIGGGGLMsLAFIIIADLV 112

                          90       100       110
                  ....*....|....*....|....*....|.
gi 1255287556 170 SPPTRSQGMAVIGVAFSLAFTLGPMLGAFLS 200
Cdd:cd17502   113 PPRERGKYQGYIGAVFGIASVAGPLIGGAFT 143
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 91-323 4.38e-08

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 54.43  E-value: 4.38e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  91 GLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVN-LSTAIVADLG 169
Cdd:COG0477    52 GWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPSPELLIAARALQGIGAGGLMpGALALIAELF 131

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 170 SPPTRSQGMAVIGVAFSLAFTLGPMLGAFLsVEMVPWISlLFAISDMLFIFCFLPETLPQEKRASSVTLGFHTAAHLLSP 249
Cdd:COG0477   132 PARERGRALGLWGAAIGLGLALGPLLGGLL-VAALGWRW-IFLINAPLGLLALVLRLRLPESRGLLLALLALALAALLLA 209

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1255287556 250 LALLRFAAVTHSQDPPAEHRLRNLRRLGLVYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMATI 323
Cdd:COG0477   210 ALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLLL 283
MFS_TRI12_like cd06179
Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; ...
 91-235 1.04e-07

Fungal trichothecene efflux pump (TRI12) of the Major Facilitator Superfamily of transporters; This family includes Fusarium sporotrichioides trichothecene efflux pump (TRI12), which may play a role in F. sporotrichioides self-protection against trichothecenes. TRI12 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340868 [Multi-domain]  Cd Length: 518  Bit Score: 54.17  E-value: 1.04e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  91 GLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVNLSTAIVADLGS 170
Cdd:cd06179    35 TWISTAWSLAQAVLGPIVGRLSDLFGRRWFFIGGNLLGVVGSIVAGTAKSVNMLIGGQALIGIGAGTQGLGAAVASELVP 114

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1255287556 171 PPTRSQGMAVIGVAFSLAFTLGPMLGAFLSVEMVP---WI----SLLFAISDMLFIFCFLPETLPQEKRASS 235
Cdd:cd06179   115 NKYRGLVQGVVNLVASPGSALGPLIAGALVEANAAgwrWIfyinAIFNALALILLFFFYHPPPRPQLHGSST 186
MFS_SLC46A1_PCFT cd17449
Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major ...
 99-247 1.60e-07

Solute carrier family 46 member 1, also called Proton-coupled folate transporter, of the Major Facilitator Superfamily of transporters; Solute carrier family 46 member 1 (SLC46A1) is also called proton-coupled folate transporter (PCFT), G21, or heme carrier protein 1 (HCP1). It functions in two ways: as an intestinal proton-coupled high-affinity folate transporter that facilitates the absorption of folates across the brush-border membrane of the small intestine; and as an intestinal heme transporter which mediates heme uptake from the gut lumen into duodenal epithelial cells. It displays a higher affinity for folate than heme. It is also expressed in the choroid plexus and is required for transport of folates into the cerebrospinal fluid. Loss of function mutations in the SLC46A1 gene results in the autosomal recessive disorder "hereditary folate malabsorption" (HFM), characterized by severe systemic and cerebral folate deficiency. SLC46A1 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341007 [Multi-domain]  Cd Length: 425  Bit Score: 53.27  E-value: 1.60e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  99 LLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKA----FLASRVIGGISkGNVNL----STAIVADLGS 170
Cdd:cd17449    76 LVGLFSVTLLGPWSDSVGRRPVLILPSLGLALQAAVYLLVMYLQLhvayFLIGRILSGLL-GDFNGilagCFAYVADVSD 154

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 171 PPTRSQGMAVIGVAFSLAFTLGPMLGA-FLSVE--MVP-WISLLFAISDMLFIFCFLPETLPQEKRASSVTLGFHTAAHL 246
Cdd:cd17449   155 RRSRTFRVAVLEACLGLAGMLASIIGGqWRKAQgyINPfWLVLALNLAAALYAAFCVGESVKEPKSARLFTTRHHQSVVR 234


                  .
gi 1255287556 247 L 247
Cdd:cd17449   235 L 235
emrD PRK11652
multidrug transporter EmrD;
96-248 2.14e-07

multidrug transporter EmrD;


Pssm-ID: 183259 [Multi-domain]  Cd Length: 394  Bit Score: 52.99  E-value: 2.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  96 AFSLLQFFSAPLtgaaSDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVN-LSTAIVADL--GSPP 172
Cdd:PRK11652   55 TYGLSQLFYGPL----SDRVGRRPVILVGMSIFILGTLVALFAHSLTVLIAASAIQGLGTGVGGvMARTLPRDLyeGTQL 130

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1255287556 173 TRSQGMAVIGVAFS--LAFTLGPMLGAFLSVEMVPWISLLFAISDMLFIFCFLPETLPQEKRASSVTLGFHtaaHLLS 248
Cdd:PRK11652  131 RHANSLLNMGILVSplLAPLIGGLLTTLFGWRACYLFLLLLGAGVTFSMARWMPETRPADARRTRVLASYR---TLLS 205
efflux_Bcr_CflA TIGR00710
drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a ...
 107-235 2.92e-07

drug resistance transporter, Bcr/CflA subfamily; This subfamily of drug efflux proteins, a part of the major faciliator family, is predicted to have 12 membrane-spanning regions. Members with known activity include Bcr (bicyclomycin resistance protein) in E. coli, Flor (chloramphenicol and florfenicol resistance) in Salmonella typhimurium DT104, and CmlA (chloramphenicol resistance) in Pseudomonas sp. plasmid R1033.


Pssm-ID: 273229 [Multi-domain]  Cd Length: 385  Bit Score: 52.39  E-value: 2.92e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 107 LTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIG--GISKGNVnLSTAIVADLGSPPTRSQGMAVIGVA 184
Cdd:TIGR00710  59 LWGPLSDRYGRRPVLLLGLFIFALSSLGLALSNNIETLLVLRFVQafGASAGSV-ISQALVRDIYPGEELSRIYSILMPV 137

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1255287556 185 FSLAFTLGPMLGA----FLSVEMVPWISLLFAISDMLFIFCFLPETLPQEKRASS 235
Cdd:TIGR00710 138 LALAPAVAPLLGGyilvWLSWHAIFAFLSLAGILLSALIFFILPETLPYEARIQI 192
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 89-223 3.90e-07

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 51.81  E-value: 3.90e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  89 FGGLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVNLST-AIVAD 167
Cdd:cd17317    26 LVALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSPSYELFLVLRFLVGVTSAGIFTVGfVLGME 105

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1255287556 168 LGSPPTRSqgmaVIGVAFSLAFTLGPMLGAFLSVEMVPWISLLFAISDMLFIFCFL 223
Cdd:cd17317   106 IVGPKYRS----FVGILFGLFWALGYMLLALLAYLIRDWRWLQLAISLPGLLFLLL 157
MFS_SLC46 cd17386
Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The ...
 92-223 4.35e-07

Solute carrier 46 (SLC46) family of the Major Facilitator Superfamily of transporters; The solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3) and similar proteins from insects and nematodes. The best-studied member is SLC46A1, also called proton-coupled folate transporter (PCFT), which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. SLC46A2, also called thymic stromal cotransporter protein (TSCOT), is a putative 12-transmembrane protein mainly expressed in the thymic cortex in a specific thymic epithelial cell (TEC) subpopulation. SLC46A3 is a lysosomal membrane protein that functions as a direct transporter of noncleavable antibody maytansine-based catabolites from the lysosome to the cytoplasm. The SLC46 family belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340944 [Multi-domain]  Cd Length: 360  Bit Score: 51.89  E-value: 4.35e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  92 LIGSAFSLlqfFSAPLTGAASDYLGRRPVMMLSLTGLAISY------AVWATSRSFKAFLASRVIGGISKGNVNLSTAI- 164
Cdd:cd17386    37 LMGSIPPL---FSSLFLGSWSDRYGRKPPLLMSLVGLLLSSlilvliVYFTTVPSVWWFYLSAIPLALFGGFTAFLSASf 113

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1255287556 165 --VADLGSPPTRSQGMAVIGVAFSLAFTLGPMLGAFL----SVEMVPWISLLFAISDMLFIFCFL 223
Cdd:cd17386   114 ayISDISSEKKRTYRMAILEVALGLGGFLGSLLSGHLfkalGYAWSFSISAALLLIALLYILFFL 178
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 91-434 1.03e-06

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 50.63  E-value: 1.03e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  91 GLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVNLSTAIVADLGS 170
Cdd:cd17478    34 GLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAAFHPEGARLASQAA 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 171 PPTRSQGMAVIGVAFSLAFTLGPMLGAFL-----SVEMVPWISLLFAISdMLFIFCFLPETLPQEKRASSVTLGFHTAAH 245
Cdd:cd17478   114 GGRRGLAMSIFSVGGNLGFALGPLIAAALvalfgGLGLLILLIIPGLAV-ALLLLRLRPLKKPEAKKAAAKSSARSTLKG 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 246 LLSPLALLRFAAVTHSqdppaehrlrnlrrlglvyflylFLFSGLEYTLSFLAHQRFQfsSLQQGKMFFFIGLTMATIQG 325
Cdd:cd17478   193 VWRALLLLLIIVFLRS-----------------------WVLSSLTTFLPFYLVQRGY--SLVFAGLLLSLFLFAGAIGT 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 326 TYARRISPGKEAAAVTRAMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGsPGQKGTIMGILRSLG 405
Cdd:cd17478   248 LIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTVVLAQELL-PGNVGLASGLMMGLS 326

                         330       340
                  ....*....|....*....|....*....
gi 1255287556 406 ALGRALGPVVAASVYWLTGAQVCFTVCSA 434
Cdd:cd17478   327 FGLGGIGAPVLGALADAFGLESVLLILAL 355
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 92-227 2.67e-06

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 49.50  E-value: 2.67e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  92 LIGSAFSLLqfFSAPLtgaaSDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISkGNVNLST--AIVADLG 169
Cdd:cd17323    44 VLGFGLGPL--IWAPL----SELYGRRPVYLVSLFIFVIFQIGCALAPNIAMLIILRFLQGFF-GSSPLAIgaGTIADLF 116

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1255287556 170 SPPTRSQGMAVIGVAFSLAFTLGPMLGAFLSVEM----VPWISLLFAISDMLFIFCFLPETL 227
Cdd:cd17323   117 TPEERGKAMGVYSLGPLLGPALGPIIGGFITQSLgwrwIFWFLAIISGFCLILIFLFLPIVL 178
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 106-420 3.96e-06

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 48.71  E-value: 3.96e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 106 PLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVN-LSTAIVADLGSPPTRSQGMAVIGVA 184
Cdd:cd17321    49 LLAGRLGDRFGRKRVFLIGLALFGLASLLCALAPSLAFLIAARALQGIGAAAIMpASLALIAATFPGERRGRALGLWGAV 128

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 185 FSLAFTLGPMLGAFLsVEMVPWISLLFaisdmlfifcflpetlpqekrassvtlgFHTAAHLLSPLALLRFAAVThsqdp 264
Cdd:cd17321   129 VGIGAALGPLLGGLL-LELFGWRWIFL----------------------------INVPIGLVALLLARTFSGAV----- 174

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 265 paehrlrnlrrlgLVYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTM---ATIQGTYARRISPGKeaaaVT 341
Cdd:cd17321   175 -------------LAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMlvaAPLAGRLADRFGPRL----VL 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 342 RAMLLLVPA----FLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVAA 417
Cdd:cd17321   238 VAGLLLTAVglllLALLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKEKAGAASGILNTARQLGGALGVALLG 317


                  ...
gi 1255287556 418 SVY 420
Cdd:cd17321   318 ALL 320
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 69-225 4.98e-06

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 48.39  E-value: 4.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  69 VDWFASAIGMPAEKRYNSV--LFGGLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLA 146
Cdd:cd17328    13 MDRFTIAGVLPDIQSDFLIddSLAGLLQTVFIISYMVLSPIFGYLGDRYNRKWILAVGILIWSAATLLSSFAPNFWQLLL 92

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 147 SRVIGGISKGNVN-LSTAIVADLGSPPTRSQGMAVIGVAFSLAFTLGPMLGAFLSVEMVPW---------ISLLFAIsdm 216
Cdd:cd17328    93 FRALVGIGEASYSpIAPTIIADLFPKEKRTRALGVFYFAIPLGSGLGYVVGGLVAQATGGWrwafrvtgvLGVLLAI--- 169


                  ....*....
gi 1255287556 217 lFIFCFLPE 225
Cdd:cd17328   170 -LLLLFVRE 177
CynX COG2807
Cyanate permease [Inorganic ion transport and metabolism];
91-424 1.05e-05

Cyanate permease [Inorganic ion transport and metabolism];


Pssm-ID: 442057 [Multi-domain]  Cd Length: 399  Bit Score: 47.56  E-value: 1.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  91 GLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGG--ISKGNVNLSTAIVADL 168
Cdd:COG2807    56 GLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPSVALLLAGTALIGagIAVGNVLLPGLIKRWF 135

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 169 gsPPTRSQGMAVIGVAFSLAFTLGPMLGAFLsVEMVPWISLLFAISdmLFIFCFLPETLPQEKRASSVTLGFHTAAHLLS 248
Cdd:COG2807   136 --PDRVGLMTGLYTAAMGLGAALAAGLTVPL-AAALGWRGALAVWA--LLALLALLLWLPLLRRRPAAAAAAPAAASLRS 210

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 249 PLALLRFAAVThsqdppaehrlrnlrrlglvyfLYLFLFSGLEYTL-SFLAH--QRFQFSSLQQGKMFF---FIGLTMAT 322
Cdd:COG2807   211 LWRSPLAWLLT----------------------LFFGLQSLLYYAVvAWLPPilRDAGLSAATAGLLLSlfqLAGIPGSL 268

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 323 IQGTYARRISPGKEAAAVTRAMLLLVPAFLLIGWAHSLPtlgLGLMLYSFAAAVVVPGLSTMVSSY-GSPGQKGTIMGIL 401
Cdd:COG2807   269 LVPLLADRLGDRRPLLLLLGLLGLAGLLGLLLAPGSLPW---LWAVLLGLGQGGLFPLALTLIGLRaRTPAEAAALSGMA 345

                         330       340
                  ....*....|....*....|...
gi 1255287556 402 RSLGALGRALGPVVAASVYWLTG 424
Cdd:COG2807   346 QSVGYLLAALGPLLVGALHDATG 368
TRI12 pfam06609
Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific ...
 85-229 1.62e-05

Fungal trichothecene efflux pump (TRI12); This family consists of several fungal specific trichothecene efflux pump proteins. Many of the genes involved in trichothecene toxin biosynthesis in Fusarium sporotrichioides are present within a gene cluster.It has been suggested that TRI12 may play a role in F. sporotrichioides self-protection against trichothecenes.


Pssm-ID: 115279 [Multi-domain]  Cd Length: 598  Bit Score: 47.35  E-value: 1.62e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  85 NSVLFGGL--IGSAFSLLqffsapLTGAASDYLGRRPVMMLS-LTGLaISYAVWATSRSFKAFLASRVIGGISKGNVNLS 161
Cdd:pfam06609  79 NQGLFSTLwtMGQAVSIL------MMGRLTDRFGRRPFVIAThIIGL-VGAIVGCTANKFNTLLAAMTLLGVAAGPAGAS 151

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1255287556 162 TAIVADLGSPPTRSQGMAVIGVAFSLAFTLGPMLGAFLSVE-MVPWISLLF----AISDMLFIFCFLPETLPQ 229
Cdd:pfam06609 152 PLFIGELMSNKTKFLGLLIVSAPTIAMNGAGPYFGQRLAIQgNWRWIFYIYiimsAIAVLLIIIWYHPPSFAQ 224
Sugar_tr pfam00083
Sugar (and other) transporter;
91-226 3.16e-05

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 46.11  E-value: 3.16e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  91 GLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATS---RSFKAFLASRVIGGISKGNVNLSTAIVAD 167
Cdd:pfam00083  49 GLIVSIFSVGCFIGSLFAGKLGDRFGRKKSLLIANVLFVIGAVLQGAAkgkWSVYQLIVGRVLVGIGVGGASVLAPMYIS 128

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 168 LGSPPTRSQGMaviGVAFSLAFTLGPMLGAFLSVEMV-----------PWISLLFAISdMLFIFCFLPET 226
Cdd:pfam00083 129 EIAPKKLRGAL---GSLYQLAITFGILLAYIFGLGLNktsnsdgwripLGLQLVPALL-LIIGLLFLPES 194
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 91-419 3.38e-05

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 46.03  E-value: 3.38e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  91 GLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVNLSTAIVADLGS 170
Cdd:cd17504    34 SWVLTAYLLVGAVSTPILGRLGDLYGRKKVLLIVLAIYTAGSLLAAFAPNLPVLIAGRALQGIGGAVFPLAFALVREEFP 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 171 PPTRSQGMAVIGVAFSLAFTLGPMLGAFLsVEMVPWISLLFAIsdmlFIFCFLpetlpqekrassvtlgfHTAAHLLSPL 250
Cdd:cd17504   114 PERVPVAQGILSATFGIGAGIGLPLGGWI-VQHLGWRWIFWTA----APVAVL-----------------LAALVPLIDL 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 251 ALLRFAAVthsqdppaehrlrnlRRLGLVYFLYLFLFSGLEYTLSFLAHQR----FQFSSLQQGKM---FFFIGLTMATI 323
Cdd:cd17504   172 RLLRRRNV---------------LLANITALLAGFGMFMVFQLLPQLLQLPtptgFGLGITEAGLLllpGALVMLIAGPL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 324 QGTYARRISPGKeaAAVTRAMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRS 403
Cdd:cd17504   237 AGRLIARVGPRR--VLLIGLVISAVGLLLLALLHSSLWALVVALLLIGIGLGLAFASLPNIVVESVPPDRTGIATGMNTV 314

                         330
                  ....*....|....*.
gi 1255287556 404 LGALGRALGPVVAASV 419
Cdd:cd17504   315 LRTIGSAIGPAIAGAI 330
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 86-424 3.90e-05

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 45.67  E-value: 3.90e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  86 SVLFGGLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKG-NVNLSTAI 164
Cdd:cd17316    34 SLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLPTPILLLVLRFLQGIGIGgEYPGASTY 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 165 VADlgSPPTRSQGMAviGVAFSLAFTLGPMLGAFLSVEMVPWISLLFAISDMLFIFCFLPetlpqekrassvtlgfhtaa 244
Cdd:cd17316   114 VAE--FAPSKRRGFA--LGLLQSGWALGALLAALVASLLIPLLSGDWGWRILFLIGALPA-------------------- 169

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 245 hLLSPLALLRFAAVThsqdppaehrLRNLRRLGLVYFLYLFLFSGLEYTLSFLAHQRFQFSSLqqgkmFFFIGLTMATIQ 324
Cdd:cd17316   170 -LLALLLRRRTLLLI----------LLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLL-----ISLGALVGALIA 233

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 325 GTYARRISPGKEAAAVTRAMLLLVPAFLLIGwAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSL 404
Cdd:cd17316   234 GLLSDRIGRKKTLVIGLILSGILALPLFYLL-SGSPTLLLLLLFILSFFVGGVWGALYAYLAELFPTEVRATGVGLSYNL 312

                         330       340
                  ....*....|....*....|
gi 1255287556 405 GALGRALGPVVAASVYWLTG 424
Cdd:cd17316   313 GRLGGGGAPPLIALLLASTG 332
MFS_SLC22A6_OAT1_like cd17446
Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar ...
 109-220 4.11e-05

Solute carrier family 22 member 6 (also called Organic anion transporter 1) and similar transporters of the Major Facilitator Superfamily; This subfamily includes solute carrier family 22 member 6 (SLC22A6, also called organic anion transporter 1 or OAT1 or para-aminohippurate (PAH) transporter), SLC22A8 (or OAT3), and SLC22A20 (or OAT6). OAT1 and OAT3 are involved in the renal elimination of endogenous and exogenous organic anions (OAs). They function as OA exchangers, coupling the uptake of OAs against an electrochemical gradient with the efflux of intracellular dicarboxylates. SLC22A20 is an OA transporter that mediates the uptake of estrone sulfate. The OAT1-like subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341004 [Multi-domain]  Cd Length: 339  Bit Score: 45.49  E-value: 4.11e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 109 GAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVNLSTAIVaDLGSPPTRsqGMAVIGVAFSLA 188
Cdd:cd17446    54 GGLSDRFGRRPLLIWSYLQMAVSGTCAAFSPSFPIYCVFRFLTGMALSGIVLNSVSL-NVEWMPTR--VRAVVGTLLGYC 130

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1255287556 189 FTLGPMLGAFLSVEMVPWISLLFAISDMLFIF 220
Cdd:cd17446   131 YTLGQLILAGVAYAIRDWRWLQLAVSLPFFIF 162
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 86-434 5.42e-05

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 45.23  E-value: 5.42e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  86 SVLFGGLIGSAFSLLQFFSAPLTGAASDYLGRR-PVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVNLST-A 163
Cdd:cd17370    32 SAAAVGLIEGLAEALGSLLRLFSGYLSDRTGKRkPLVILGYGLSALAKPLLALAGSWQLVLLLRILERLGKGIRTPPRdA 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 164 IVADLGSPPTRsqgmaviGVAFSL--AF-TLGPMLGAFLSVEMVPWISLLFAisdMLFIFCFLPetlpqekrassvtlgf 240
Cdd:cd17370   112 LLADATPPSGR-------GKAFGLhrALdTLGAVLGPLLAALLLYLLGGNYR---TIFLLAAIP---------------- 165

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 241 htaahLLSPLALLRFAAVTHSQDPPAEHRLRNLRRLGLVYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTM 320
Cdd:cd17370   166 -----ALLALLILLFVVKEYPRPPKLRKKSKKTSLKKLPKAFWLYLLAVALFALGNFSFAFLILRAQELGLSAALIPLLY 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 321 ATIQGTYA----------RRISPGKEAAAvtrAMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGS 390
Cdd:cd17370   241 ALFNLVYAlaaypagrlsDRIGRKKLLIL---GYLSLALAYLGFALGSSLWLLLLGFILWGLYMGAQESIERAAVADLVP 317

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....
gi 1255287556 391 PGQKGTIMGILRSLGALGRALGPVVAASVYWLTGAQVCFTVCSA 434
Cdd:cd17370   318 AELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAV 361
MFS_LmrB_MDR_like cd17503
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ...
 106-200 5.54e-05

Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341046 [Multi-domain]  Cd Length: 380  Bit Score: 45.26  E-value: 5.54e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 106 PLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGN-VNLSTAIVADLGSPPTRSQGMAVIGVA 184
Cdd:cd17503    49 PLSGWLADRFGTRRLFLTALALFTLGSLLCGLAPNLASLIIFRILQGFGGGVlIPLAQTILLRIYPPEKRGAAMGLVGLV 128

                          90
                  ....*....|....*.
gi 1255287556 185 FSLAFTLGPMLGAFLS 200
Cdd:cd17503   129 ILLAPAIGPTLGGWLT 144
MFS_OAT cd17374
Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion ...
 104-228 6.26e-05

Organic anion transporters of the Major Facilitator Superfamily of transporters; Organic anion transporters (OATs) generally display broad substrate specificity and they facilitate the exchange of extracellular with intracellular organic anions (OAs). Several OATs have been characterized including OAT1-10 and urate anion exchanger 1 (URAT1, also called SLC22A12). Many OATs occur in renal proximal tubules, the site of active drug secretion. OATs mediate the absorption, distribution, and excretion of a diverse array of environmental toxins, and clinically important drugs, including anti-HIV therapeutics, anti-tumor drugs, antibiotics, anti-hypertensives, and anti-inflammatories, and therefore is critical for the survival of the mammalian species. OAT falls into the SLC22 (solute carrier 22) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340932 [Multi-domain]  Cd Length: 341  Bit Score: 44.97  E-value: 6.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 104 SAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVNLSTAIvadLGSPPTRSQGMAVIGV 183
Cdd:cd17374    51 GALIFGHLSDRFGRKFILLLSLLQLAIFGTCAAFAPTFPVYCVLRFLAGFAVSGISINTLI---LGTEWTTPRHRALAIT 127

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1255287556 184 AFSLAFTLGPMLGAFLSVEMVPWISLLFAISDMLFIFCFLPETLP 228
Cdd:cd17374   128 LTSCFFSIGQMLLAGLAYAIRDWRLLQLVVSVPFFLFFLYSWWLP 172
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 91-232 6.50e-05

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 45.39  E-value: 6.50e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  91 GLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGI-SKGNVNLSTAIVADLG 169
Cdd:TIGR00898 130 DLTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSPNYTVFLVFRLLVGMgIGGIWVQAVVLNTEFL 209

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1255287556 170 SPPTRsqgmAVIGVAFSLAFTLGPMLGAFLSVEMVPWISLLFAISDMLFIFCFLPETLPQEKR 232
Cdd:TIGR00898 210 PKKQR----AIVGTLIQVFFSLGLVLLPLVAYFIPDWRWLQLAVSLPTFLFFLLSWFVPESPR 268
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 91-253 7.44e-05

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 44.86  E-value: 7.44e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  91 GLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVNLST-AIVADLG 169
Cdd:cd17477    34 GLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPWVWFLLRFVMGIGLAGLFVVSeSWLNALA 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 170 SPPTRSQGMAVIGVAFSLAFTLGPMLGAFLSVEMVPW---ISLLFAISdmLFIFCFLPETLPQEKRASSVTLGfhtAAHL 246
Cdd:cd17477   114 TNENRGRVLGLYSTVLGLGFALGPLLLALVGTAGALPfliAAVLLLLA--LVPLLLTRRAAPEIEEAESISLR---RLLR 188


                  ....*..
gi 1255287556 247 LSPLALL 253
Cdd:cd17477   189 IAPLALL 195
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
343-434 1.01e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 44.19  E-value: 1.01e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 343 AMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVAASVYWL 422
Cdd:COG2814    81 GLLLFALGSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADLVPPERRGRALGLLGAGLGLGPALGPLLGGLLADL 160

                          90
                  ....*....|..
gi 1255287556 423 TGAQVCFTVCSA 434
Cdd:COG2814   161 FGWRWVFLVNAV 172
MFS_SLC22A1_2_3 cd17379
Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, ...
 102-220 1.06e-04

Solute carrier family 22 members 1, 2, and 3 (also called Organic cation transporters 1, 2, and 3) of the Major Facilitator Superfamily of transporters; This sufamily includes solute carrier family 22 member 1 (SLC22A1, also called organic cation transporter 1 or OCT1), SLC22A2 (or OCT2), SLC22A3 (or OCT3), and similar proteins. OCT1-3 have similar basic functional properties: they are able to translocate a variety of structurally different organic cations in both directions across the plasma membrane; to translocate organic cations independently from sodium, chloride or proton gradients; and to function as electrogenic uniporters for cations or as electroneutral cation exchangers. They show overlapping but distinct substrate and inhibitor specificities, and different tissue expression pattern. In humans, OCT1 is strongly expressed in the liver, OCT2 is highly expressed in the kidney where it is localized at the basolateral membrane of renal proximal tubules, and OCT3 is most strongly expressed in skeletal muscle. OCTs are broad-specificity transporters that play a critical role in the excretion and distribution of endogeneous organic cations and for the uptake, elimination and distribution of cationic drugs, toxins, and environmental waste products. The SLC22A1-3 subfamily belongs to the Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340937 [Multi-domain]  Cd Length: 340  Bit Score: 44.26  E-value: 1.06e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 102 FFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGI-SKGNVNLSTAIVADLGSPPTRSqgmaV 180
Cdd:cd17379    47 LIGSIVIGYLADRFGRKVCFLISILGNGVSGVLMAFSPNYPWFLIFRFLQGLfGKGGWMTGYVLVTEFVGSKYRR----T 122

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1255287556 181 IGVAFSLAFTLGPMLGAFLSVEMVPWISLLFAISDMLFIF 220
Cdd:cd17379   123 VGIVYQMFFTLGLLILPGIAYFIPHWRWLQLAVTLPNFLF 162
MFS_MdtG_MDR_like cd17391
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ...
 88-419 2.29e-04

Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340949 [Multi-domain]  Cd Length: 380  Bit Score: 43.41  E-value: 2.29e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  88 LFGGLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVNLSTAIVAd 167
Cdd:cd17391    36 LWSGLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASLGMAIVIGLMAFVTNVWQLLILRLLQGVFSGYVPNATALIA- 114

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 168 lGSPPTRSQG-----MAVIGVAFSLaftLGPMLGAFLS----VEMVPWI-SLLFAISDMLFIFC----FLPETLPQEKRA 233
Cdd:cd17391   115 -SQTPKEKSGwalgtLSTGVVAGTL---IGPLLGGFLAdlfgIRNVFFItGGLLFLAFLLTLFFvkedFKPVEKKKMVST 190

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 234 SSVTLGFhTAAHLLSPLALLRFAAVTHSQdppaehrlrnlrRLGLVYFLYLFLFSGLEYTLSFLAHqrFQFSSLQQGKMF 313
Cdd:cd17391   191 KEVWNSV-PNPSLLISLFVTTFIIQLANQ------------SIEPILTLYIRQLMGDASNLAFISG--LVFSATGVSSLL 255

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 314 FfigltmATIQGTYARRISPGKE--AAAVTRAMLLLVPAFLLIGWahslpTLGLGLMLYSFAAAVVVPGLSTMVSSYGSP 391
Cdd:cd17391   256 S------APRLGKLGDRIGHHRIllGALLASALLYIPQAFVQTPW-----QLGILRFLLGLATGGLLPAINSLLAKITPK 324

                         330       340
                  ....*....|....*....|....*...
gi 1255287556 392 GQKGTIMGILRSLGALGRALGPVVAASV 419
Cdd:cd17391   325 EVAGRIFGYNQSFQYLGNVAGPLLGSAI 352
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
281-434 3.85e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 42.56  E-value: 3.85e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 281 FLYLFLFSGLEYTLSFLAH---QRFQFSSLQQG---KMFFFIGLTMATIQGTYARRISPGKeaaAVTRAMLLLVPAFLLI 354
Cdd:COG2223    11 TLAFFLAFGVWYLWSVLAPplaEEFGLSAAQLGllfAIPVLVGALLRIPLGFLVDRFGPRR---VLLIGLLLLGIGLLLL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 355 GWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVAASVYWLTGAQVCFTVCSA 434
Cdd:COG2223    88 ALAVSYWLLLLLGLLLGIGGGGSFAVGIALVSKWFPPDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGI 167
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 300-420 3.88e-04

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 42.54  E-value: 3.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 300 QRFQFSSLQQGKMFFFIGLTMATIQ---GTYARRISPGKEAAAvtrAMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAV 376
Cdd:cd17478    24 AKLGLSYAQAGLLVSVFSITSSLLQplfGYLADRKPRRYLLPL---GPLLTGLGLSLLGFAPNYWLLLLLVALAGIGSAA 100

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1255287556 377 VVPGLSTMVSSYgSPGQKGTIMGILRSLGALGRALGPVVAASVY 420
Cdd:cd17478   101 FHPEGARLASQA-AGGRRGLAMSIFSVGGNLGFALGPLIAAALV 143
PRK10473 PRK10473
MdtL family multidrug efflux MFS transporter;
104-261 6.12e-04

MdtL family multidrug efflux MFS transporter;


Pssm-ID: 182486 [Multi-domain]  Cd Length: 392  Bit Score: 41.93  E-value: 6.12e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 104 SAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVNLST-AIVADLGSPPTRSQGMAVIG 182
Cdd:PRK10473   54 AMLFAGKIADRSGRKPVAIPGAALFIIASLLCSLAETSSLFLAGRFLQGIGAGCCYVVAfAILRDTLDDRRRAKVLSLLN 133

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 183 VAFSLAFTLGPMLGaFLSVEMVPWISLLFAISDM---LFIFCF--LPETLPQEKRASSvTLGFHTAAHLLSPLALLRFAA 257
Cdd:PRK10473  134 GITCIIPVLAPVLG-HLIMLKFPWQSLFYTMAAMgilVLLLSLfiLKETRPARAPAAS-SKPRENSESLLNRFFLSRLVI 211


                  ....
gi 1255287556 258 VTHS 261
Cdd:PRK10473  212 TTLS 215
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 86-228 6.26e-04

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 41.79  E-value: 6.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  86 SVLFGGLIGSAFSllqffsapltGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGnvnLSTAIV 165
Cdd:cd17315    42 SLLLGAAIGSLFG----------GPLADRFGRRKSLLIAAVLYVIGALLSALAPNVWVLIVGRFLLGLGVG---LASVLV 108

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1255287556 166 ----ADLGSPPTRsqgmAVIGVAFSLAFTLGPMLGAFLSVEMV----PWISLLFAISD-----MLFIFCFLPETLP 228
Cdd:cd17315   109 plyiSEIAPAKIR----GALGTLNQLMITFGILLAYLLGLALSlsppGWWRLMFALAAvpallQLLLMFFLPESRA 180
MFS_1 pfam07690
Major Facilitator Superfamily;
279-434 6.55e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 41.63  E-value: 6.55e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 279 VYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQGKMFFFIGLTMATIQ---GTYARRISPGKeaaAVTRAMLLLVPAFLLIG 355
Cdd:pfam07690   4 AAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQplaGRLSDRFGRRR---VLLIGLLLFALGLLLLL 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1255287556 356 WAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGALGRALGPVVAASVYWLTGAQVCFTVCSA 434
Cdd:pfam07690  81 FASSLWLLLVLRVLQGLGAGALFPAALALIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAI 159
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 92-226 8.44e-04

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 41.49  E-value: 8.44e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  92 LIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGnvnlstaiVADLGSP 171
Cdd:cd17360    39 LIVSSTVAGAAVGAAIGGWLNDRFGRRPCILLADALFTIGAIVMAAAPNKEVLIVGRVLVGLGVG--------IASMTVP 110

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1255287556 172 -------PTRSQGMAVigVAFSLAFTLGPML----GAFLSVEMVPWiSLLFAISDM-----LFIFCFLPET 226
Cdd:cd17360   111 lyiaeaaPPRIRGRLV--TINVLFITGGQFVayviNGAFSYLPGGW-RWMLGLAAVpavlqFIGLLFLPES 178
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
85-199 1.02e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.43  E-value: 1.02e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  85 NSVLFGGLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAV--WATSRSFKAFLASRVIGGISKGNVN-LS 161
Cdd:COG2211   261 LSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLlfFLGPGNLWLLLVLAALAGIGLGAILvLP 340

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*
gi 1255287556 162 TAIVADLGSPPTRSQGMAVIGVAFS-------LAFTLGPMLGAFL 199
Cdd:COG2211   341 WAMLADVVDYDEWKTGRRREGLYFGiftfaikLGQALAGALAGLL 385
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 86-226 1.10e-03

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 41.01  E-value: 1.10e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  86 SVLFGGLIGSAFSllqffsapltGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVN-LSTAI 164
Cdd:cd17359    44 SALLGAAIGALFA----------GRLADRFGRRKTLLISAVLFFISALGSAFSPNFTIFIIARIIGGLAVGGASaLVPMY 113

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1255287556 165 VADLgSPP-------TRSQGMAVIG--VAFSLAFTLGPMLGAFLSVEMV----PWISLLFAISdMLFIFCFLPET 226
Cdd:cd17359   114 IAEV-APAeirgrlvSLNQLMIVFGqlLAYIVNYLIANAGGADWLGAEGwrwmLGLEAIPAIL-FLLGMLFIPES 186
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 90-419 1.19e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 41.19  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  90 GGLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVnlsTAIVADLG 169
Cdd:TIGR00895  54 LGFLFSAGLIGMAFGALFFGPLADRIGRRRVLLWSILLFSVFTLLCALATNVTQLLILRFLAGLGLGGL---MPNLNALV 130

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 170 SP--PTRSQGMAViGVAFSlAFTLGPMLGAFLSVEMVP--------WISLLFAISDMLFIFCFLPETLPQEKRASSVTLG 239
Cdd:TIGR00895 131 SEyaPKRFRGTAV-GLMFC-GYPIGAAVGGFLAGWLIPvfgwrslfYVGGIAPLLLLLLLMRFLPESIDFLVSKRPETVR 208

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 240 FHTAAHLLSPLALLRFAAVTHSQDPP----------AEHRLRNLRRLGLVYFLYLFLFSGLEYTLSFL-AHQRFQFS-SL 307
Cdd:TIGR00895 209 RIVNAIAPQMQAEAQSALPEQKSTQGtkrsvfkalfQGKTARITVLLWLLYFMLLVGVYFLTNWLPKLmVELGFSLSlAA 288

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 308 QQGKMFFFIGLTMATIQGTYARRISPGkeaaaVTRAMLLLVPAFL-LIGWAHSLPT--LGLGLMLYSFAAAVVVPGLSTM 384
Cdd:TIGR00895 289 TGGALFNFGGVIGSIIFGWLADRLGPR-----VTALLLLLGAVFAvLVGSTLFSPTllLLLGAIAGFFVNGGQSGLYALM 363

                         330       340       350
                  ....*....|....*....|....*....|....*
gi 1255287556 385 VSSYgSPGQKGTIMGILRSLGALGRALGPVVAASV 419
Cdd:TIGR00895 364 ALFY-PTAIRATGVGWAIGIGRLGAIIGPILAGYL 397
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 91-226 1.35e-03

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 41.09  E-value: 1.35e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  91 GLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFK---AFLASRVIGGISKGnvnLSTAIVAD 167
Cdd:cd17357    52 SLIVSIFFIGGAIGSFISAFLANRFGRKNGLLISNALLVVSSLLMFLSKSAKspeLLIFGRFLVGIACG---LSTGFVPM 128

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1255287556 168 LGSPPTRSQGMAVIGVAFSLAFTLGPMLGAFLSVEMV-------PWI---SLLFAISdMLFIFCFLPET 226
Cdd:cd17357   129 YLQEISPSELRGALGSLTQIGVTLGILLGQVFGLPSVlgtetlwPYLlffPGIPALL-QLAALPFFPES 196
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 79-220 2.51e-03

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 39.92  E-value: 2.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  79 PAEKRYN-SVLFGGLIGSAFSL-LQFFSAPLtGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKG 156
Cdd:cd17313   271 AASSHYGaGVRMGAWGLLIFSLaFLIFSLPI-GKLGKKIGRKKVYLIGLVLFAVGMALMALVHNVTVALVLFALGGIGWA 349

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1255287556 157 NVN-LSTAIVADLGSPPTRSQGM--AVIGVAFSLA-----FTLGPMLGAFLSVEMVPWISLLFAISDMLFIF 220
Cdd:cd17313   350 TINiNPYPLVSDYHSESGRGQGTdtGLLNLAISLAqilvsLLAGPIIDVKGYGTVFPVAAVASFLSLVGALF 421
MFS_FucP_MFSD4_like cd17333
Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein ...
 86-437 3.53e-03

Bacterial fucose permease, eukaryotic Major facilitator superfamily domain-containing protein 4, and similar proteins; This family is composed of bacterial L-fucose permease (FucP), eukaryotic Major facilitator superfamily domain-containing protein 4 (MFSD4) proteins, and similar proteins. L-fucose permease facilitates the uptake of L-fucose across the boundary membrane with the concomitant transport of protons into the cell; it can also transport L-galactose and D-arabinose. The MFSD4 subfamily consists of two vertebrate members: MFSD4A and MFSD4B. The function of MFSD4A is unknown. MFSD4B is more commonly know as Sodium-dependent glucose transporter 1 (NaGLT1), a primary fructose transporter in rat renal brush-border membranes that also facilitates sodium-independent urea uptake. The FucP/MFSD4 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340891 [Multi-domain]  Cd Length: 372  Bit Score: 39.61  E-value: 3.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  86 SVLFGGLIGSAFSllqffsapltGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKG-NVNLSTAI 164
Cdd:cd17333    39 SQNAGYLIGSLLA----------GFLMKRLGRRRTLILGLLLISLALALIFATPSIYLFVVLMFLAGLGAGiLDTGANTF 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 165 VADLgSPPTRSQGMAVIGVAFSLAFTLGPMLGAFL-----SVEMVPWISLLFAISDMLFIF-CFLPETLPQEKRASSVTL 238
Cdd:cd17333   109 VGAL-FEESSATRLNVLHGFFGLGALIGPLIATSLltselSWSWAYLIIGLIYLLLAILILlTLFPELPSARNPQQSVGA 187

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 239 GFHTAAHLLSPLALLRFAavthsqdppaehrlrnlrrlglvyfLYLFLFSGLEYTL-----SFLAHQRF---QFSSLqqG 310
Cdd:cd17333   188 FSASASRLLRNPSIILGA-------------------------LALFLYVGAETAFsswvpSYLVEKKHvsdGLAGY--L 240

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 311 KMFFFIGLTMATIQGTY-ARRISPgkeaAAVTRAMLLLVPAFLLIGWAHSLPTLGL-GLMLYSFAAAVVVP-GLSTMVSS 387
Cdd:cd17333   241 LSGFWVGITIGRLLGGPiSRRIKP----HTLLVLSGSGALLGLLILLLAPTLVVGLvATALLGLFMAALFPtILSLGISN 316

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1255287556 388 YgsPGQKGTIMGILRSLGALGRALGPVVAASVYWLTGAQVCFTVCSALFL 437
Cdd:cd17333   317 L--PYAKGKGTSVLLAAGSIGGAIIPFIMGFIAEAVGIQTAMLLITILYA 364
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 83-220 3.64e-03

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 39.46  E-value: 3.64e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  83 RYNSVLFGGLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVNLST 162
Cdd:cd17478   225 RGYSLVFAGLLLSLFLFAGAIGTLIGGPLSDRFGRRRVIIASLLLAAPFLLLFLLTPGIWSYILLVLAGFLLFASFPVTV 304

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1255287556 163 AIVADLGSpptRSQGMA---VIGVAFSLAFTLGPMLGAF---LSVEMVPWISLLFAISDMLFIF 220
Cdd:cd17478   305 VLAQELLP---GNVGLAsglMMGLSFGLGGIGAPVLGALadaFGLESVLLILALLPLLGALLAF 365
MFS_ExuT_GudP_like cd17319
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ...
 91-416 3.72e-03

Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340877 [Multi-domain]  Cd Length: 358  Bit Score: 39.48  E-value: 3.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  91 GLIGSAFSLLQFFSAPLTGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVIGGISKGNVN-LSTAIVADLG 169
Cdd:cd17319    41 GLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSLTSLYVLRFLLGVAEAGFFpGAIKALAEWF 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 170 SPPTRSQGMAVigvafslaFTLGPMLGAFLSVEMVPWISLLFAISDMLFIFCFLpetlpqekrassvtlgfhtaAHLLSP 249
Cdd:cd17319   121 PARERGRATGL--------FNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLL--------------------GLLLAV 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 250 LALLRFAAVthsqdppaehrlrnlRRLGLVYFLYLFLFSGLEYTLSFLAHQRFQFSSLQQG---KMFFFIGLTMATIQGT 326
Cdd:cd17319   173 LWWFYLRQV---------------WGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGllaAIPFLAGAIGMILGGR 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 327 YARRISPGKEAAAVTRAMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGLSTMVSSYGSPGQKGTIMGILRSLGA 406
Cdd:cd17319   238 LSDRLLRGARRLVIIIGLLLAAVGLLLAYLTTSPVVAVILLSLAGFGIGAASPVFWSLPADLLPGEAAATAGGLINSGGN 317

                         330
                  ....*....|
gi 1255287556 407 LGRALGPVVA 416
Cdd:cd17319   318 LGGFVAPLLI 327
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 71-226 4.28e-03

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 39.48  E-value: 4.28e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  71 WFASAIGMpaekrynsvlfGGLIGSAFSllqffsapltGAASDYLGRRPVMMLSLTGLAISYAVWATSRSFKAFLASRVI 150
Cdd:cd17358    45 WFGSLLTL-----------GALIGALLS----------GKLADRIGRKRTLLISAIPCILGWLLIAFAKDVWMLYLGRFL 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 151 GGISKGNVNLSTAI-VADLGSPPTRsqgmAVIGVAFSLAFTLGPM----LGAFLSVEMVPWISLLFAISdMLFIFCFLPE 225
Cdd:cd17358   104 AGFGGGAASVVVPVyIAEIAPKNVR----GALGSLNQLLVNIGILlgyvLGSFLPWRTLALIGAIPPVV-FLILLFFIPE 178


                  .
gi 1255287556 226 T 226
Cdd:cd17358   179 S 179
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
91-424 8.42e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 38.34  E-value: 8.42e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556  91 GLIGSAFSLLQFFSA---PLTGAASDYLG-----RRPVMMLSLTGLAISYAV------WATSRSFKAFLASRVIGGISKG 156
Cdd:COG2211    46 ALVGLILLVARLWDAitdPLIGALSDRTRtrwgrRRPWILIGAIPLALSFVLlftapdLSPTGKLIYALVTYLLLGLAYT 125

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 157 NVNLS-TAIVADLGSPPT-RSQGMAVIGVAFSLAFTLGPMLGAFL----------SVEMVPWISLLFAISDMLFIFCFLP 224
Cdd:COG2211   126 LVNIPySALGAELTPDYEeRTRLSSWRFAFAGLGGLLASVLPPPLvaafggdaalGYRLTALIFAVLGLLAFLLTFFGTK 205

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 225 ETLPQEKRASSVtlgFHTAAHLLSPLALLRFAAvthsqdppaehrlrnlrrlglVYFLYLFLFSGLEYTLSFLAHQRFQF 304
Cdd:COG2211   206 ERPVPEEEKVSL---KESLKALLKNRPFLLLLL---------------------AYLLFFLALALVAALLLYYFKYVLGL 261

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1255287556 305 SSLQQGKMFFFIGLTMATIQ---GTYARRISPgKEAAAVTRAMLLLVPAFLLIGWAHSLPTLGLGLMLYSFAAAVVVPGL 381
Cdd:COG2211   262 SAALVGLLLALYFLAALLGAplwPRLAKRFGK-KKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALAGIGLGAILVLP 340

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1255287556 382 STMVSSYGSPGQK-------GTIMGILRSLGALGRALGPVVAASVYWLTG 424
Cdd:COG2211   341 WAMLADVVDYDEWktgrrreGLYFGIFTFAIKLGQALAGALAGLLLALFG 390
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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