NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1269612324|ref|NP_001344233.1|]
View 

tumor suppressor candidate 3 isoform 2 [Mus musculus]

Protein Classification

OST3/OST6 family protein( domain architecture ID 10520659)

OST3/OST6 family protein similar to Homo sapiens magnesium transporter protein 1 and tumor suppressor candidate 3, which are required for cellular magnesium uptake and vertebrate embryonic development

Gene Ontology:  GO:0022857
PubMed:  10358084
SCOP:  4005064

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
OST3_OST6 pfam04756
OST3 / OST6 family, transporter family; The proteins in this family are part of a complex of ...
 45-215 1.37e-42

OST3 / OST6 family, transporter family; The proteins in this family are part of a complex of eight ER proteins that transfers core oligosaccharide from dolichol carrier to Asn-X-Ser/Thr motifs. This family includes both OST3 and OST6, each of which contains four predicted transmembrane helices. Disruption of OST3 and OST6 leads to a defect in the assembly of the complex. Hence, the function of these genes seems to be essential for recruiting a fully active complex necessary for efficient N-glycosylation. These proteins are also thought to be novel Mg2+ transporters.


:

Pssm-ID: 461420  Cd Length: 294  Bit Score: 145.08  E-value: 1.37e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612324  45 QLNMNSAPTFMHFPSKGRPKRA----DTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYL 120
Cdd:pfam04756  90 SLGLQTAPHLLLFPPTGGPKISdsepDQYDFTRGGFSAEQLAAFLSRHTGVPIPIKRPINYSKIIITFIIVLGVVTLLKK 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612324 121 RRNNL-EFIYNKTGWAMVSL-----------------------------SYIHGSSQAQFVAESHIILVLNAAITMGMVL 170
Cdd:pfam04756 170 ARPYLlPILQNRNLWAALSLifillftsgymfnhirgvpyvardgkggiSYFAGGSQNQFGIETQIVAALYGLLALLVIL 249

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1269612324 171 LNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPY 215
Cdd:pfam04756 250 LTIKVPRIKDPKVQRVAVIVWAGVLFLFFSFLLSVFRIKNPGYPF 294
 
Name Accession Description Interval E-value
OST3_OST6 pfam04756
OST3 / OST6 family, transporter family; The proteins in this family are part of a complex of ...
 45-215 1.37e-42

OST3 / OST6 family, transporter family; The proteins in this family are part of a complex of eight ER proteins that transfers core oligosaccharide from dolichol carrier to Asn-X-Ser/Thr motifs. This family includes both OST3 and OST6, each of which contains four predicted transmembrane helices. Disruption of OST3 and OST6 leads to a defect in the assembly of the complex. Hence, the function of these genes seems to be essential for recruiting a fully active complex necessary for efficient N-glycosylation. These proteins are also thought to be novel Mg2+ transporters.


Pssm-ID: 461420  Cd Length: 294  Bit Score: 145.08  E-value: 1.37e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612324  45 QLNMNSAPTFMHFPSKGRPKRA----DTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYL 120
Cdd:pfam04756  90 SLGLQTAPHLLLFPPTGGPKISdsepDQYDFTRGGFSAEQLAAFLSRHTGVPIPIKRPINYSKIIITFIIVLGVVTLLKK 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612324 121 RRNNL-EFIYNKTGWAMVSL-----------------------------SYIHGSSQAQFVAESHIILVLNAAITMGMVL 170
Cdd:pfam04756 170 ARPYLlPILQNRNLWAALSLifillftsgymfnhirgvpyvardgkggiSYFAGGSQNQFGIETQIVAALYGLLALLVIL 249

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1269612324 171 LNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPY 215
Cdd:pfam04756 250 LTIKVPRIKDPKVQRVAVIVWAGVLFLFFSFLLSVFRIKNPGYPF 294
 
Name Accession Description Interval E-value
OST3_OST6 pfam04756
OST3 / OST6 family, transporter family; The proteins in this family are part of a complex of ...
 45-215 1.37e-42

OST3 / OST6 family, transporter family; The proteins in this family are part of a complex of eight ER proteins that transfers core oligosaccharide from dolichol carrier to Asn-X-Ser/Thr motifs. This family includes both OST3 and OST6, each of which contains four predicted transmembrane helices. Disruption of OST3 and OST6 leads to a defect in the assembly of the complex. Hence, the function of these genes seems to be essential for recruiting a fully active complex necessary for efficient N-glycosylation. These proteins are also thought to be novel Mg2+ transporters.


Pssm-ID: 461420  Cd Length: 294  Bit Score: 145.08  E-value: 1.37e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612324  45 QLNMNSAPTFMHFPSKGRPKRA----DTFDLQRIGFAAEQLAKWIADRTDVHIRVFRPPNYSGTIALALLVSLVGGLLYL 120
Cdd:pfam04756  90 SLGLQTAPHLLLFPPTGGPKISdsepDQYDFTRGGFSAEQLAAFLSRHTGVPIPIKRPINYSKIIITFIIVLGVVTLLKK 169

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1269612324 121 RRNNL-EFIYNKTGWAMVSL-----------------------------SYIHGSSQAQFVAESHIILVLNAAITMGMVL 170
Cdd:pfam04756 170 ARPYLlPILQNRNLWAALSLifillftsgymfnhirgvpyvardgkggiSYFAGGSQNQFGIETQIVAALYGLLALLVIL 249

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1269612324 171 LNEAATSKGDVGKRRIICLVGLGLVVFFFSFLLSIFRSKYHGYPY 215
Cdd:pfam04756 250 LTIKVPRIKDPKVQRVAVIVWAGVLFLFFSFLLSVFRIKNPGYPF 294
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH