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Conserved domains on  [gi|1276740342|ref|NP_001344914|]
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tudor domain-containing protein 6 isoform 4 [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Tudor_TDRD6_rpt2 cd20421
second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 239-379 5.30e-76

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410492  Cd Length: 130  Bit Score: 247.72  E-value: 5.30e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  239 DYFYPQLQLGVTEPVVVTQVCHPHRIHCQLRSLSQEIHRLSESMAQVYRAPVGTddedsgsatweEREESPDKPGSPCAS 318
Cdd:cd20421      1 DYFYPQLQVGVTETVVVTEVTDPHRIFCQLRSLSQELKRLSESMHQYYEGRVGS-----------GYETRPEKLGSPCAA 69

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1276740342  319 CGLDGQWYRALLLETFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYG 379
Cdd:cd20421     70 RGSDGRWYRAVLQQVFSANRVVEVLHVDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCALFG 130
Tudor_SF super family cl02573
Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally ...
 1331-1473 7.78e-68

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.


The actual alignment was detected with superfamily member cd20426:

Pssm-ID: 470623  Cd Length: 140  Bit Score: 225.07  E-value: 7.78e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1331 IKAYATVIDGPEYFWCQFAdSEKLQYLETEVQSAGKQLSDRRSCTQCPQIGDPCIVRYREDGHYYRALITNICDgELASV 1410
Cdd:cd20426      1 IEAYATAVDSPEYFWCQFA-TEKIQCLAVKVQEAGEQVADRGNFIPSIYVGDPCIVKYSEDNHWYRALVTKIND-NLVSV 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1276740342 1411 RLVDFGNAEDCVdAKELWSIPSELLLVPMQAFPCCLAGFSVSGGVCPQEGNDYFYDIVTEDVL 1473
Cdd:cd20426     79 RFVDYGNEEDVV-REQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEANDYFYEIVTEDLL 140
Tudor_TDRD6_rpt1 cd20420
first Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 6-136 1.89e-67

first Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


:

Pssm-ID: 410491  Cd Length: 132  Bit Score: 223.46  E-value: 1.89e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342    6 GLPTPGASLALRVSFVDVHPEVIPVQLWGLVGQRREEYVRLSREIQEAAATRG-PWALGGASASPGELCLVQVGLMWHRC 84
Cdd:cd20420      1 GLPAPGAVLSLRVSRVDVRPGVPLVRLWGLLRERKGEYQRLTREIQAAVKMRGcGAGDGGAEPSVGDLCLVEVGGLWHRC 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1276740342   85 RVVSRQAQDSRVFLLDEGRTITAGAGSLAPGRSEFFHLPSEVLGCVLAGLVP 136
Cdd:cd20420     81 RVVSRQGDDYRVFLLDEGRTVVARAKSLARGRKDFFSLPPEVLGCVLANLVP 132
Tudor_SF super family cl02573
Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally ...
 787-911 9.27e-63

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.


The actual alignment was detected with superfamily member cd20424:

Pssm-ID: 470623  Cd Length: 126  Bit Score: 209.67  E-value: 9.27e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  787 YYYSTHDLKIGSEELVYVTHADDPWTFYCQLARNTNVLEQLSYNIMQLSKALLNLKAStLAPGTLCLARYTDGNWYRGII 866
Cdd:cd20424      1 YYYSMHDIKIGSEEEVYITYVNDPWTFYCQLARNAGVLDQLASAISRLSSEIRKLELS-VNPGTLCLAKYSDQHWYRGII 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1276740342  867 IE-KEPSKVFFVDFGNTYIAV-DHLLPIPRDAHDVLLLPMQALKCSL 911
Cdd:cd20424     80 ITnKNSTEVFFVDYGNTEKVEkEDMLPIPSDAYELLLLPMQAIKCSL 126
Tudor_SF super family cl02573
Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally ...
 1119-1233 1.00e-51

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.


The actual alignment was detected with superfamily member cd20425:

Pssm-ID: 470623  Cd Length: 115  Bit Score: 177.65  E-value: 1.00e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1119 KTSVYVSHINDLSDFYIQLIEDEAEINNLSERLNDVRTRPQYHTGPQWQSGDVICAVFPEDNLWYRALVMEQQPNGLLSV 1198
Cdd:cd20425      1 KTEVYVSHVNSPSDFYVQLAQDEDELSMISEKLNASKANDEEVECESLQLGDLICAEYPEDGLWYRAVVKEKIPNNLVSV 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1276740342 1199 QFIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSL 1233
Cdd:cd20425     81 QFIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115
Tudor_SF super family cl02573
Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally ...
 578-698 1.94e-29

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.


The actual alignment was detected with superfamily member cd20439:

Pssm-ID: 470623  Cd Length: 125  Bit Score: 114.51  E-value: 1.94e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  578 LEVGSTVEVKVSHIENPGSFWCQLMRNAQGFRTLMCDIEDYCKSSEpSPYEGDTRVCLAKRTASGRWSRALISGAHSLEH 657
Cdd:cd20439      6 FKPGSVVDVKCSYVNSPGDFWCQLQTKSSELKSLMKQIQSYYLIHN-DPYKHGQIACVAKYSKDGKWYRAAVLKQVSAKE 84

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1276740342  658 VRVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSLYNL 698
Cdd:cd20439     85 VDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125
Tudor_SF super family cl02573
Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally ...
 494-536 9.80e-16

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.


The actual alignment was detected with superfamily member cd20422:

Pssm-ID: 470623  Cd Length: 135  Bit Score: 75.62  E-value: 9.80e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1276740342  494 FYDAQVEFVKSPSEFWIRLRKHKNTFSKLTKRMCSFYSSAKAL 536
Cdd:cd20422      1 FYDAQVEFVKDPSEFWIRLGEHAVPFSKLMRSMTAFYSQASKL 43
 
Name Accession Description Interval E-value
Tudor_TDRD6_rpt2 cd20421
second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 239-379 5.30e-76

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410492  Cd Length: 130  Bit Score: 247.72  E-value: 5.30e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  239 DYFYPQLQLGVTEPVVVTQVCHPHRIHCQLRSLSQEIHRLSESMAQVYRAPVGTddedsgsatweEREESPDKPGSPCAS 318
Cdd:cd20421      1 DYFYPQLQVGVTETVVVTEVTDPHRIFCQLRSLSQELKRLSESMHQYYEGRVGS-----------GYETRPEKLGSPCAA 69

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1276740342  319 CGLDGQWYRALLLETFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYG 379
Cdd:cd20421     70 RGSDGRWYRAVLQQVFSANRVVEVLHVDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCALFG 130
Tudor_TDRD6_rpt7 cd20426
seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 1331-1473 7.78e-68

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410497  Cd Length: 140  Bit Score: 225.07  E-value: 7.78e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1331 IKAYATVIDGPEYFWCQFAdSEKLQYLETEVQSAGKQLSDRRSCTQCPQIGDPCIVRYREDGHYYRALITNICDgELASV 1410
Cdd:cd20426      1 IEAYATAVDSPEYFWCQFA-TEKIQCLAVKVQEAGEQVADRGNFIPSIYVGDPCIVKYSEDNHWYRALVTKIND-NLVSV 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1276740342 1411 RLVDFGNAEDCVdAKELWSIPSELLLVPMQAFPCCLAGFSVSGGVCPQEGNDYFYDIVTEDVL 1473
Cdd:cd20426     79 RFVDYGNEEDVV-REQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEANDYFYEIVTEDLL 140
Tudor_TDRD6_rpt1 cd20420
first Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 6-136 1.89e-67

first Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410491  Cd Length: 132  Bit Score: 223.46  E-value: 1.89e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342    6 GLPTPGASLALRVSFVDVHPEVIPVQLWGLVGQRREEYVRLSREIQEAAATRG-PWALGGASASPGELCLVQVGLMWHRC 84
Cdd:cd20420      1 GLPAPGAVLSLRVSRVDVRPGVPLVRLWGLLRERKGEYQRLTREIQAAVKMRGcGAGDGGAEPSVGDLCLVEVGGLWHRC 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1276740342   85 RVVSRQAQDSRVFLLDEGRTITAGAGSLAPGRSEFFHLPSEVLGCVLAGLVP 136
Cdd:cd20420     81 RVVSRQGDDYRVFLLDEGRTVVARAKSLARGRKDFFSLPPEVLGCVLANLVP 132
Tudor_TDRD6_rpt5 cd20424
fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 787-911 9.27e-63

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410495  Cd Length: 126  Bit Score: 209.67  E-value: 9.27e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  787 YYYSTHDLKIGSEELVYVTHADDPWTFYCQLARNTNVLEQLSYNIMQLSKALLNLKAStLAPGTLCLARYTDGNWYRGII 866
Cdd:cd20424      1 YYYSMHDIKIGSEEEVYITYVNDPWTFYCQLARNAGVLDQLASAISRLSSEIRKLELS-VNPGTLCLAKYSDQHWYRGII 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1276740342  867 IE-KEPSKVFFVDFGNTYIAV-DHLLPIPRDAHDVLLLPMQALKCSL 911
Cdd:cd20424     80 ITnKNSTEVFFVDYGNTEKVEkEDMLPIPSDAYELLLLPMQAIKCSL 126
Tudor_TDRD6_rpt6 cd20425
sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 1119-1233 1.00e-51

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410496  Cd Length: 115  Bit Score: 177.65  E-value: 1.00e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1119 KTSVYVSHINDLSDFYIQLIEDEAEINNLSERLNDVRTRPQYHTGPQWQSGDVICAVFPEDNLWYRALVMEQQPNGLLSV 1198
Cdd:cd20425      1 KTEVYVSHVNSPSDFYVQLAQDEDELSMISEKLNASKANDEEVECESLQLGDLICAEYPEDGLWYRAVVKEKIPNNLVSV 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1276740342 1199 QFIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSL 1233
Cdd:cd20425     81 QFIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115
TUDOR pfam00567
Tudor domain;
1329-1448 1.40e-29

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 114.76  E-value: 1.40e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1329 KLIKAYATVIDGPEYFWCQF-ADSEKLQYLETEVQSAGKQLSdrRSCTQcPQIGDPCIVRYREDGHYYRALITNICDGEL 1407
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPkSDSKKLEKLTEELQEYYASKP--PESLP-PAVGDGCVAAFSEDGKWYRAKITESLDDGL 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1276740342 1408 ASVRLVDFGNAEdCVDAKELWSIPSELLLVPMQAFPCCLAG 1448
Cdd:pfam00567   78 VEVLFIDYGNTE-TVPLSDLRPLPPELESLPPQAIKCQLAG 117
Tudor_TDRD15_rpt4 cd20439
fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 578-698 1.94e-29

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410510  Cd Length: 125  Bit Score: 114.51  E-value: 1.94e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  578 LEVGSTVEVKVSHIENPGSFWCQLMRNAQGFRTLMCDIEDYCKSSEpSPYEGDTRVCLAKRTASGRWSRALISGAHSLEH 657
Cdd:cd20439      6 FKPGSVVDVKCSYVNSPGDFWCQLQTKSSELKSLMKQIQSYYLIHN-DPYKHGQIACVAKYSKDGKWYRAAVLKQVSAKE 84

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1276740342  658 VRVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSLYNL 698
Cdd:cd20439     85 VDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125
TUDOR pfam00567
Tudor domain;
1119-1235 4.17e-27

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 107.44  E-value: 4.17e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1119 KTSVYVSHINDLSDFYIQLIEDEAEINNLSERLNDVRTRPQyHTGPQWQSGDVICAVFPEDNLWYRALVMEQQPNGLLSV 1198
Cdd:pfam00567    2 TIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKP-PESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVEV 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1276740342 1199 QFIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSLWG 1235
Cdd:pfam00567   81 LFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117
TUDOR pfam00567
Tudor domain;
582-697 8.08e-23

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 95.50  E-value: 8.08e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  582 STVEVKVSHIENPGSFWCQLMRNAQGFRTLMCDIEDYCKSSEPSPYE---GDTRVCLAKRtaSGRWSRALISGAHSLEHV 658
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPpavGDGCVAAFSE--DGKWYRAKITESLDDGLV 78

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1276740342  659 RVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSLYN 697
Cdd:pfam00567   79 EVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117
TUDOR pfam00567
Tudor domain;
802-913 2.20e-22

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 93.96  E-value: 2.20e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  802 VYVTHADDPWTFYCQLARNTNVLEQLSYNiMQLSKALLNLKASTLAPGTLCLARYT-DGNWYRGIIIEKEPS---KVFFV 877
Cdd:pfam00567    5 VVVSHIESPSTFYIQPKSDSKKLEKLTEE-LQEYYASKPPESLPPAVGDGCVAAFSeDGKWYRAKITESLDDglvEVLFI 83

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1276740342  878 DFGNT-YIAVDHLLPIPRDAhdvLLLPMQALKCSLSD 913
Cdd:pfam00567   84 DYGNTeTVPLSDLRPLPPEL---ESLPPQAIKCQLAG 117
Tudor_TDRD6_rpt3 cd20422
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 494-536 9.80e-16

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410493  Cd Length: 135  Bit Score: 75.62  E-value: 9.80e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1276740342  494 FYDAQVEFVKSPSEFWIRLRKHKNTFSKLTKRMCSFYSSAKAL 536
Cdd:cd20422      1 FYDAQVEFVKDPSEFWIRLGEHAVPFSKLMRSMTAFYSQASKL 43
TUDOR pfam00567
Tudor domain;
250-379 5.96e-13

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 66.99  E-value: 5.96e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  250 TEPVVVTQVCHPHRIHCQLRSLSQEIHRLSESMAQVYRAPvgtddedsgsatweEREESPDKPGSPCA---SCglDGQWY 326
Cdd:pfam00567    2 TIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASK--------------PPESLPPAVGDGCVaafSE--DGKWY 65

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1276740342  327 RALLLETfRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYG 379
Cdd:pfam00567   66 RAKITES-LDDGLVEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 1376-1434 2.99e-10

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 57.28  E-value: 2.99e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1276740342  1376 QCPQIGDPCIVRYrEDGHYYRALITNICDGELASVRLVDFGNaEDCVDAKELWSIPSEL 1434
Cdd:smart00333    1 PTFKVGDKVAARW-EDGEWYRARIVKVDGEQLYEVFFIDYGN-EEVVPPSDLRQLPEEL 57
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 844-895 7.65e-10

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 56.13  E-value: 7.65e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1276740342   844 STLAPGTLCLARYTDGNWYRGIIIEKEPSK---VFFVDFGNT-YIAVDHLLPIPRD 895
Cdd:smart00333    1 PTFKVGDKVAARWEDGEWYRARIVKVDGEQlyeVFFIDYGNEeVVPPSDLRQLPEE 56
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 1164-1219 3.62e-09

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 54.20  E-value: 3.62e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1276740342  1164 PQWQSGDVICAVFpEDNLWYRALVMEQQPNGLLSVQFIDYGNMSVVHTNRTGRLGP 1219
Cdd:smart00333    1 PTFKVGDKVAARW-EDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPE 55
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 624-676 1.34e-05

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 44.19  E-value: 1.34e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1276740342   624 PSPYEGDtrVCLAKRTaSGRWSRALISGAHSLEHVRVVFVDYGDRDVVSTKDI 676
Cdd:smart00333    1 PTFKVGD--KVAARWE-DGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDL 50
TUDOR pfam00567
Tudor domain;
69-133 3.93e-04

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 41.96  E-value: 3.93e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1276740342   69 PGELCLVQVGLMWHRCRV-VSRQAQDSRVFLLDEGRTITAGAGSLAPGRSEFFHLPSEVLGCVLAG 133
Cdd:pfam00567   52 DGCVAAFSEDGKWYRAKItESLDDGLVEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 311-364 4.69e-04

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 39.95  E-value: 4.69e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1276740342   311 KPGSPCASCGLDGQWYRALLLETFRPQRCaQVLHVDYGRKELVSCSSLRyLLPE 364
Cdd:smart00333    4 KVGDKVAARWEDGEWYRARIVKVDGEQLY-EVFFIDYGNEEVVPPSDLR-QLPE 55
 
Name Accession Description Interval E-value
Tudor_TDRD6_rpt2 cd20421
second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 239-379 5.30e-76

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410492  Cd Length: 130  Bit Score: 247.72  E-value: 5.30e-76
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  239 DYFYPQLQLGVTEPVVVTQVCHPHRIHCQLRSLSQEIHRLSESMAQVYRAPVGTddedsgsatweEREESPDKPGSPCAS 318
Cdd:cd20421      1 DYFYPQLQVGVTETVVVTEVTDPHRIFCQLRSLSQELKRLSESMHQYYEGRVGS-----------GYETRPEKLGSPCAA 69

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1276740342  319 CGLDGQWYRALLLETFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYG 379
Cdd:cd20421     70 RGSDGRWYRAVLQQVFSANRVVEVLHVDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCALFG 130
Tudor_TDRD6_rpt7 cd20426
seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 1331-1473 7.78e-68

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410497  Cd Length: 140  Bit Score: 225.07  E-value: 7.78e-68
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1331 IKAYATVIDGPEYFWCQFAdSEKLQYLETEVQSAGKQLSDRRSCTQCPQIGDPCIVRYREDGHYYRALITNICDgELASV 1410
Cdd:cd20426      1 IEAYATAVDSPEYFWCQFA-TEKIQCLAVKVQEAGEQVADRGNFIPSIYVGDPCIVKYSEDNHWYRALVTKIND-NLVSV 78

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1276740342 1411 RLVDFGNAEDCVdAKELWSIPSELLLVPMQAFPCCLAGFSVSGGVCPQEGNDYFYDIVTEDVL 1473
Cdd:cd20426     79 RFVDYGNEEDVV-REQVRALPSELLKIPVQAFPCCLSGFNLSEGLWSDEANDYFYEIVTEDLL 140
Tudor_TDRD6_rpt1 cd20420
first Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 6-136 1.89e-67

first Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410491  Cd Length: 132  Bit Score: 223.46  E-value: 1.89e-67
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342    6 GLPTPGASLALRVSFVDVHPEVIPVQLWGLVGQRREEYVRLSREIQEAAATRG-PWALGGASASPGELCLVQVGLMWHRC 84
Cdd:cd20420      1 GLPAPGAVLSLRVSRVDVRPGVPLVRLWGLLRERKGEYQRLTREIQAAVKMRGcGAGDGGAEPSVGDLCLVEVGGLWHRC 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1276740342   85 RVVSRQAQDSRVFLLDEGRTITAGAGSLAPGRSEFFHLPSEVLGCVLAGLVP 136
Cdd:cd20420     81 RVVSRQGDDYRVFLLDEGRTVVARAKSLARGRKDFFSLPPEVLGCVLANLVP 132
Tudor_TDRD6_rpt5 cd20424
fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 787-911 9.27e-63

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410495  Cd Length: 126  Bit Score: 209.67  E-value: 9.27e-63
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  787 YYYSTHDLKIGSEELVYVTHADDPWTFYCQLARNTNVLEQLSYNIMQLSKALLNLKAStLAPGTLCLARYTDGNWYRGII 866
Cdd:cd20424      1 YYYSMHDIKIGSEEEVYITYVNDPWTFYCQLARNAGVLDQLASAISRLSSEIRKLELS-VNPGTLCLAKYSDQHWYRGII 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1276740342  867 IE-KEPSKVFFVDFGNTYIAV-DHLLPIPRDAHDVLLLPMQALKCSL 911
Cdd:cd20424     80 ITnKNSTEVFFVDYGNTEKVEkEDMLPIPSDAYELLLLPMQAIKCSL 126
Tudor_TDRD6_rpt6 cd20425
sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 1119-1233 1.00e-51

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410496  Cd Length: 115  Bit Score: 177.65  E-value: 1.00e-51
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1119 KTSVYVSHINDLSDFYIQLIEDEAEINNLSERLNDVRTRPQYHTGPQWQSGDVICAVFPEDNLWYRALVMEQQPNGLLSV 1198
Cdd:cd20425      1 KTEVYVSHVNSPSDFYVQLAQDEDELSMISEKLNASKANDEEVECESLQLGDLICAEYPEDGLWYRAVVKEKIPNNLVSV 80

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1276740342 1199 QFIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSL 1233
Cdd:cd20425     81 QFIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115
Tudor_TDRD15_rpt5 cd20440
fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 789-911 2.94e-37

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410511  Cd Length: 127  Bit Score: 136.82  E-value: 2.94e-37
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  789 YSTHDLKIGSEELVYVTHADDPWTFYCQLARNTNVLEQLSYNIMQLSKaLLNLKASTLAPGTLCLARY-TDGNWYRGIII 867
Cdd:cd20440      1 YSSFNIKVGSEEEVYITHVYSPAKFYCQLDRNTEILEALMEKIAEISK-LFNSQILDNCKTRLCLAKYfEDGQWYRALAH 79

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1276740342  868 EKEPS---KVFFVDFGNTYIAV-DHLLPIPRDAHDVLLLPMQALKCSL 911
Cdd:cd20440     80 PVESSshlSVYFVDYGNKQIVEkNEVLPIPDTAVDLLLTPMQAIKCCL 127
TUDOR pfam00567
Tudor domain;
1329-1448 1.40e-29

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 114.76  E-value: 1.40e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1329 KLIKAYATVIDGPEYFWCQF-ADSEKLQYLETEVQSAGKQLSdrRSCTQcPQIGDPCIVRYREDGHYYRALITNICDGEL 1407
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPkSDSKKLEKLTEELQEYYASKP--PESLP-PAVGDGCVAAFSEDGKWYRAKITESLDDGL 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1276740342 1408 ASVRLVDFGNAEdCVDAKELWSIPSELLLVPMQAFPCCLAG 1448
Cdd:pfam00567   78 VEVLFIDYGNTE-TVPLSDLRPLPPELESLPPQAIKCQLAG 117
Tudor_TDRD15_rpt4 cd20439
fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 578-698 1.94e-29

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410510  Cd Length: 125  Bit Score: 114.51  E-value: 1.94e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  578 LEVGSTVEVKVSHIENPGSFWCQLMRNAQGFRTLMCDIEDYCKSSEpSPYEGDTRVCLAKRTASGRWSRALISGAHSLEH 657
Cdd:cd20439      6 FKPGSVVDVKCSYVNSPGDFWCQLQTKSSELKSLMKQIQSYYLIHN-DPYKHGQIACVAKYSKDGKWYRAAVLKQVSAKE 84

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1276740342  658 VRVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSLYNL 698
Cdd:cd20439     85 VDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125
TUDOR pfam00567
Tudor domain;
1119-1235 4.17e-27

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 107.44  E-value: 4.17e-27
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1119 KTSVYVSHINDLSDFYIQLIEDEAEINNLSERLNDVRTRPQyHTGPQWQSGDVICAVFPEDNLWYRALVMEQQPNGLLSV 1198
Cdd:pfam00567    2 TIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKP-PESLPPAVGDGCVAAFSEDGKWYRAKITESLDDGLVEV 80

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1276740342 1199 QFIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSLWG 1235
Cdd:pfam00567   81 LFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117
Tudor_TDRD6_rpt4 cd20423
fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 631-703 3.02e-24

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410494  Cd Length: 80  Bit Score: 97.94  E-value: 3.02e-24
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1276740342  631 TRVCLAKRTASGRWSRALISGAHS-LEHVRVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSLYNLIQPMG 703
Cdd:cd20423      6 NPVCLAKYSEDGKWCRALIDNVYEpVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQPSG 79
TUDOR pfam00567
Tudor domain;
582-697 8.08e-23

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 95.50  E-value: 8.08e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  582 STVEVKVSHIENPGSFWCQLMRNAQGFRTLMCDIEDYCKSSEPSPYE---GDTRVCLAKRtaSGRWSRALISGAHSLEHV 658
Cdd:pfam00567    1 STIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASKPPESLPpavGDGCVAAFSE--DGKWYRAKITESLDDGLV 78

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1276740342  659 RVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSLYN 697
Cdd:pfam00567   79 EVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117
TUDOR pfam00567
Tudor domain;
802-913 2.20e-22

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 93.96  E-value: 2.20e-22
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  802 VYVTHADDPWTFYCQLARNTNVLEQLSYNiMQLSKALLNLKASTLAPGTLCLARYT-DGNWYRGIIIEKEPS---KVFFV 877
Cdd:pfam00567    5 VVVSHIESPSTFYIQPKSDSKKLEKLTEE-LQEYYASKPPESLPPAVGDGCVAAFSeDGKWYRAKITESLDDglvEVLFI 83

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1276740342  878 DFGNT-YIAVDHLLPIPRDAhdvLLLPMQALKCSLSD 913
Cdd:pfam00567   84 DYGNTeTVPLSDLRPLPPEL---ESLPPQAIKCQLAG 117
Tudor_TDRD15_rpt1 cd20436
first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 16-168 1.02e-20

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410507  Cd Length: 147  Bit Score: 90.56  E-value: 1.02e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342   16 LRVSFVDVHPEVIPVQLWGLVGQRRE-EYVRLSREIQEAAATRGPWALGgasaspgELCLVQ--VGLMWHRCRVVSRQAQ 92
Cdd:cd20436      2 LKITHRVCHPKEVLVKFQGQYNSICElDYHILQNEIQNATKSKSSWGVG-------EFCLVEdtTSGEWYRGRVLEKIDE 74

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1276740342   93 DSRVFLLDEGRTITAGAGSLAPGRSEFFHLPSEVLGCVLAGLVPAGgggtgggepQQWSPRAVDFLSNLQGKEVHG 168
Cdd:cd20436     75 KYEVFLIDRGEVLNVHATNMASASGELFQLPPKAVCGIFANILPIG---------EKWSSTAVNYFSSLIGSQVKG 141
Tudor_TDRD15_rpt5 cd20440
fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 578-695 1.28e-20

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410511  Cd Length: 127  Bit Score: 89.44  E-value: 1.28e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  578 LEVGSTVEVKVSHIENPGSFWCQLMRNAQGFRTLMCDIEDYCKSSEPSPYEGD-TRVCLAKRTASGRWSRALISGAHSLE 656
Cdd:cd20440      6 IKVGSEEEVYITHVYSPAKFYCQLDRNTEILEALMEKIAEISKLFNSQILDNCkTRLCLAKYFEDGQWYRALAHPVESSS 85

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1276740342  657 HVRVVFVDYGDRDVVSTKDILSVSDVFFQV---RAQAFRCSL 695
Cdd:cd20440     86 HLSVYFVDYGNKQIVEKNEVLPIPDTAVDLlltPMQAIKCCL 127
Tudor_TDRD15_rpt2 cd20437
second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 248-377 1.10e-18

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410508  Cd Length: 120  Bit Score: 83.62  E-value: 1.10e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  248 GVTEPVVVTQVCHPHRIHCQLRSLSQEIHRLSESMAQVYrapvgtddeDSGSatwEEREESPDKPGSPCASCGLDGQWYR 327
Cdd:cd20437      2 GTTEKVKITAAVSPSKFYCQLLSWEPELSKLTTQMTLHY---------ESVS---KELNPSCENFGLLCAAKGKDGQWHR 69

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1276740342  328 ALLlETFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCAL 377
Cdd:cd20437     70 GFL-QQLLPPSQVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSL 118
Tudor_TDRD15_rpt5 cd20440
fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 1332-1446 2.38e-17

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410511  Cd Length: 127  Bit Score: 80.19  E-value: 2.38e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1332 KAYATVIDGPEYFWCQFA-DSEKLQYLETEVQSAGKQLSDRRSCTQCPQIgdpCIVRYREDGHYYRALITNICDGELASV 1410
Cdd:cd20440     13 EVYITHVYSPAKFYCQLDrNTEILEALMEKIAEISKLFNSQILDNCKTRL---CLAKYFEDGQWYRALAHPVESSSHLSV 89

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1276740342 1411 RLVDFGNAEdCVDAKELWSIP---SELLLVPMQAFPCCL 1446
Cdd:cd20440     90 YFVDYGNKQ-IVEKNEVLPIPdtaVDLLLTPMQAIKCCL 127
Tudor_TDRD15_rpt6 cd20441
sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 1131-1236 3.18e-17

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410512  Cd Length: 108  Bit Score: 79.01  E-value: 3.18e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1131 SDFYIQLIEDEAEINNLSERLNDVRTRPQYHTGPQWQSGDVICAVFPEDNLWYRALVMEQQPNGLLSVQFIDYGNMSVVH 1210
Cdd:cd20441      3 SRFFIQLSEDEKVILQLAEELNETSEKSRENAAVKLKVGDLVAAEYDEDLALYRAVITAVLPGKSFKVEFIDYGNTAVVD 82

                           90       100
                   ....*....|....*....|....*.
gi 1276740342 1211 TNRTGRLGPVDAVLPALCLHCSLWGL 1236
Cdd:cd20441     83 KSNIYTLQEKFLSLPRLSIPCSLSGV 108
Tudor_TDRD6_rpt3 cd20422
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 494-536 9.80e-16

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410493  Cd Length: 135  Bit Score: 75.62  E-value: 9.80e-16
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1276740342  494 FYDAQVEFVKSPSEFWIRLRKHKNTFSKLTKRMCSFYSSAKAL 536
Cdd:cd20422      1 FYDAQVEFVKDPSEFWIRLGEHAVPFSKLMRSMTAFYSQASKL 43
Tudor_TDRD15_rpt2 cd20437
second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 580-695 2.86e-15

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410508  Cd Length: 120  Bit Score: 73.99  E-value: 2.86e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  580 VGSTVEVKVSHIENPGSFWCQLMRNAQGFRTLMCDIEDYCKSSE---PSPYEGDTRVCLAKRTaSGRWSRALISGAHSLE 656
Cdd:cd20437      1 VGTTEKVKITAAVSPSKFYCQLLSWEPELSKLTTQMTLHYESVSkelNPSCENFGLLCAAKGK-DGQWHRGFLQQLLPPS 79

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1276740342  657 HVRVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSL 695
Cdd:cd20437     80 QVKVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSL 118
Tudor_TDRD6_rpt4 cd20423
fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 310-380 5.59e-14

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410494  Cd Length: 80  Bit Score: 68.66  E-value: 5.59e-14
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1276740342  310 DKPGSPC-ASCGLDGQWYRALLLETFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYGL 380
Cdd:cd20423      3 SLPNPVClAKYSEDGKWCRALIDNVYEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNL 74
Tudor_TDRD15_rpt2 cd20437
second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 796-913 9.68e-14

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410508  Cd Length: 120  Bit Score: 69.37  E-value: 9.68e-14
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  796 IGSEELVYVTHADDPWTFYCQLARNTNVLEQLSYNIM--------QLSKALLNLkastlapGTLCLARYTDGNWYRGIII 867
Cdd:cd20437      1 VGTTEKVKITAAVSPSKFYCQLLSWEPELSKLTTQMTlhyesvskELNPSCENF-------GLLCAAKGKDGQWHRGFLQ 73

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|
gi 1276740342  868 EKEPS---KVFFVDFGNT-YIAVDHLLPIPRdahDVLLLPMQALKCSLSD 913
Cdd:cd20437     74 QLLPPsqvKVWFIDYGNSeAVSSHSVLKLPP---DFFSLPLMSFPCSLSC 120
Tudor_TDRD15_rpt4 cd20439
fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 1338-1449 1.44e-13

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410510  Cd Length: 125  Bit Score: 69.06  E-value: 1.44e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1338 IDGPEYFWCQF-ADSEKLQYLETEVQSAGKQLSDRrscTQCPQIGdpCIVRYREDGHYYRALITNICDGELASVRLVDFG 1416
Cdd:cd20439     19 VNSPGDFWCQLqTKSSELKSLMKQIQSYYLIHNDP---YKHGQIA--CVAKYSKDGKWYRAAVLKQVSAKEVDVIFVDYG 93

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1276740342 1417 NAEDcVDAKELWSIPSELLLVPMQAFPCCLAGF 1449
Cdd:cd20439     94 NQER-VLISDLRAIKPQFLLLEGQAFRCSLNNF 125
TUDOR pfam00567
Tudor domain;
250-379 5.96e-13

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 66.99  E-value: 5.96e-13
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  250 TEPVVVTQVCHPHRIHCQLRSLSQEIHRLSESMAQVYRAPvgtddedsgsatweEREESPDKPGSPCA---SCglDGQWY 326
Cdd:pfam00567    2 TIDVVVSHIESPSTFYIQPKSDSKKLEKLTEELQEYYASK--------------PPESLPPAVGDGCVaafSE--DGKWY 65

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1276740342  327 RALLLETfRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYG 379
Cdd:pfam00567   66 RAKITES-LDDGLVEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117
Tudor_TDRD1_rpt1 cd20408
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 802-915 1.21e-12

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410479  Cd Length: 130  Bit Score: 66.62  E-value: 1.21e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  802 VYVTHADDPWTFYCQLArNTNVLEQLsyniMQLSKALLNLKASTL-------APGTLCLARYT-DGNWYRGII----IEK 869
Cdd:cd20408      1 GTVTEFKNPGEFYIQIY-TLEVLESL----VKLTSQLKKTYASVNnhkeyipEVGEVCVAKYSeDQNWYRALVqtvdVQQ 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1276740342  870 EPSKVFFVDFGN-TYIAVDHLLPIPRdahDVLLLPMQALKCSLSDIP 915
Cdd:cd20408     76 KKAGVFYIDYGNeETVPLNRIQPLKK---DIELFPPCAIKCCLANVK 119
Tudor_TDRD6_rpt5 cd20424
fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 577-695 1.37e-12

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410495  Cd Length: 126  Bit Score: 66.37  E-value: 1.37e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  577 ELEVGSTVEVKVSHIENPGSFWCQLMRNAQGFRTLMCDIEDYCKSSEP--SPYEGDTrVCLAKRTaSGRWSRALISgaHS 654
Cdd:cd20424      7 DIKIGSEEEVYITYVNDPWTFYCQLARNAGVLDQLASAISRLSSEIRKleLSVNPGT-LCLAKYS-DQHWYRGIII--TN 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1276740342  655 LEHVRVVFVDYGDRDVVSTKDILSVS----DVFFqVRAQAFRCSL 695
Cdd:cd20424     83 KNSTEVFFVDYGNTEKVEKEDMLPIPsdayELLL-LPMQAIKCSL 126
Tudor_AtTudor1-like cd20443
Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor ...
 1133-1239 4.28e-12

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410514 [Multi-domain]  Cd Length: 117  Bit Score: 64.80  E-value: 4.28e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1133 FYIQLIEDE--AEINNLSERLNdVRTRPQYHTGPQWQSGDVICAVFPEDNLWYRALVME------QQPNGLLSVQFIDYG 1204
Cdd:cd20443      4 FYVQVVSDQrlSSIQQQLEGLS-LKDKANPPGGFNPKKGELVLAQFSADNSWNRAMVVNaprqgtQSPKDEYEVFYIDYG 82

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1276740342 1205 NMSVVHTNRTGRLGPVDAVLPALCLHCSLWGLSVP 1239
Cdd:cd20443     83 NQETVPLSALRPLDPSVSSAPGLAQLCSLAHIKVP 117
Tudor_TDRD15_rpt5 cd20440
fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 1114-1212 5.71e-12

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410511  Cd Length: 127  Bit Score: 64.78  E-value: 5.71e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1114 IAPGFKTSVYVSHINDLSDFYIQLIEDEAEINNLSERLNDVRTRPQYHTGPQWQSGDVICAVFpEDNLWYRALVMEQQPN 1193
Cdd:cd20440      6 IKVGSEEEVYITHVYSPAKFYCQLDRNTEILEALMEKIAEISKLFNSQILDNCKTRLCLAKYF-EDGQWYRALAHPVESS 84

                           90
                   ....*....|....*....
gi 1276740342 1194 GLLSVQFIDYGNMSVVHTN 1212
Cdd:cd20440     85 SHLSVYFVDYGNKQIVEKN 103
Tudor_TDRD15_rpt6 cd20441
sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 1341-1448 7.62e-12

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410512  Cd Length: 108  Bit Score: 63.61  E-value: 7.62e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1341 PEYFWCQFADSEKLQYLETEVQSAGKQLSDRRSCTQCpQIGDPCIVRYREDGHYYRALITNICDGELASVRLVDFGNAEd 1420
Cdd:cd20441      2 PSRFFIQLSEDEKVILQLAEELNETSEKSRENAAVKL-KVGDLVAAEYDEDLALYRAVITAVLPGKSFKVEFIDYGNTA- 79

                           90       100
                   ....*....|....*....|....*...
gi 1276740342 1421 CVDAKELWSIPSELLLVPMQAFPCCLAG 1448
Cdd:cd20441     80 VVDKSNIYTLQEKFLSLPRLSIPCSLSG 107
Tudor_TDRD1_rpt4 cd20411
fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 1350-1448 1.16e-11

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410482  Cd Length: 116  Bit Score: 63.62  E-value: 1.16e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1350 DSEKLQYLETEVQSAGKQLSDRRSCTqcPQIGDPCIVRYREDGHYYRALITNICDGElASVRLVDFGNAEdCVDAKELWS 1429
Cdd:cd20411     22 NVEKLKALMTELAEYCSKQSVPQQFR--PRIGDACCARFTGDKNWYRAVVLETSDSE-VKVLYADYGNTE-TLPLSRILP 97

                           90
                   ....*....|....*....
gi 1276740342 1430 IPSELLLVPMQAFPCCLAG 1448
Cdd:cd20411     98 ITKSHLELPFQIIRCSLAG 116
Tudor_TDRD1_rpt3 cd20410
third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 1378-1435 1.65e-11

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410481 [Multi-domain]  Cd Length: 59  Bit Score: 61.20  E-value: 1.65e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1276740342 1378 PQIGDPCIVRYREDGHYYRALITNICDGELASVRLVDFGNAEDcVDAKELWSIPSELL 1435
Cdd:cd20410      3 PIVGEPCCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNVEE-VTLDKLRKITSTFL 59
Tudor_TDRD6_rpt2 cd20421
second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 577-696 1.73e-11

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410492  Cd Length: 130  Bit Score: 63.21  E-value: 1.73e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  577 ELEVGSTVEVKVSHIENPGSFWCQLMRNAQGFRTLMCDIEDYCKSSEPSPYEGDTRV----ClAKRTASGRWSRALISGA 652
Cdd:cd20421      6 QLQVGVTETVVVTEVTDPHRIFCQLRSLSQELKRLSESMHQYYEGRVGSGYETRPEKlgspC-AARGSDGRWYRAVLQQV 84

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*
gi 1276740342  653 HSLEH-VRVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSLY 696
Cdd:cd20421     85 FSANRvVEVLHVDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCALF 129
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
 1380-1430 2.17e-11

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 60.22  E-value: 2.17e-11
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1276740342 1380 IGDPCIVRYREDGHYYRALITNICDGELASVRLVDFGNaEDCVDAKELWSI 1430
Cdd:cd20379      1 VGDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGN-TETVPLSDLRPL 50
Tudor_TDRD6_rpt4 cd20423
fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 1383-1446 1.37e-10

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410494  Cd Length: 80  Bit Score: 59.03  E-value: 1.37e-10
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1276740342 1383 PCIVRYREDGHYYRALITNICDG-ELASVRLVDFGNAEdCVDAKELWSIPSELLLVPMQAFPCCL 1446
Cdd:cd20423      8 VCLAKYSEDGKWCRALIDNVYEPvEMVEVTYVDYGNKE-LVSLKNLRSISEEFLKLKAQAFRCSL 71
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
 1169-1213 1.43e-10

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 57.91  E-value: 1.43e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1276740342 1169 GDVICAVFPEDNLWYRALVMEQQPNGLLSVQFIDYGNMSVVHTNR 1213
Cdd:cd20379      2 GDLCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSD 46
Tudor_TDRD6_rpt7 cd20426
seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 584-717 1.90e-10

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410497  Cd Length: 140  Bit Score: 60.59  E-value: 1.90e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  584 VEVKVSHIENPGSFWCQLmrNAQGFRTLMCDIEDYCKSSE------PSPYEGDTrvCLAKRTASGRWSRALISGAHSlEH 657
Cdd:cd20426      1 IEAYATAVDSPEYFWCQF--ATEKIQCLAVKVQEAGEQVAdrgnfiPSIYVGDP--CIVKYSEDNHWYRALVTKIND-NL 75

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  658 VRVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSLYNLIQPMGenpfVWDEKAVQAF 717
Cdd:cd20426     76 VSVRFVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGFNLSEG----LWSDEANDYF 131
Tudor_TDRD15_rpt2 cd20437
second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 1117-1233 2.44e-10

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410508  Cd Length: 120  Bit Score: 59.74  E-value: 2.44e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1117 GFKTSVYVSHINDLSDFYIQLIEDEAEINNLSERLNDVRTRPQYHTGPQWQSGDVICAVFPEDNLWYRALVMEQQPNGLL 1196
Cdd:cd20437      2 GTTEKVKITAAVSPSKFYCQLLSWEPELSKLTTQMTLHYESVSKELNPSCENFGLLCAAKGKDGQWHRGFLQQLLPPSQV 81

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1276740342 1197 SVQFIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSL 1233
Cdd:cd20437     82 KVWFIDYGNSEAVSSHSVLKLPPDFFSLPLMSFPCSL 118
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 1376-1434 2.99e-10

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 57.28  E-value: 2.99e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*....
gi 1276740342  1376 QCPQIGDPCIVRYrEDGHYYRALITNICDGELASVRLVDFGNaEDCVDAKELWSIPSEL 1434
Cdd:smart00333    1 PTFKVGDKVAARW-EDGEWYRARIVKVDGEQLYEVFFIDYGN-EEVVPPSDLRQLPEEL 57
Tudor_TDRD15_rpt3 cd20438
third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 1123-1233 5.90e-10

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410509  Cd Length: 141  Bit Score: 59.41  E-value: 5.90e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1123 YVSHINDLSDFYIQLIEDEAEINNLSERLNDV--RTRPQYHTGPQWQSGDVICAVFPEDNLWYRALVMEQqpNGL-LSVQ 1199
Cdd:cd20438     10 FVEYVLNPSNFWIRTDEYNNEFQALMKNIADIynLCGNDEELLKKPEPGLLCCARYSKDRHYYRAVITEV--LDLkVSVY 87

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1276740342 1200 FIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSL 1233
Cdd:cd20438     88 FLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSL 121
Tudor_TDRD6_rpt3 cd20422
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 1378-1464 7.48e-10

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410493  Cd Length: 135  Bit Score: 59.06  E-value: 7.48e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1378 PQIGDPCIVRYREDGhYYRALITNIcDGELASVRLVDFGNAE--DCVDAKELwsiPSELLLVPMQAFPCCLAGFSVSGGV 1455
Cdd:cd20422     50 PQPGQLCCAKWKEDR-YYRAIVTAV-KGKMVEVFLVDRGNTEmvDWYDVKKL---LPQFRELPALALKCCLADICPLGER 124


                   ....*....
gi 1276740342 1456 CPQEGNDYF 1464
Cdd:cd20422    125 WSPEAISAF 133
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 844-895 7.65e-10

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 56.13  E-value: 7.65e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1276740342   844 STLAPGTLCLARYTDGNWYRGIIIEKEPSK---VFFVDFGNT-YIAVDHLLPIPRD 895
Cdd:smart00333    1 PTFKVGDKVAARWEDGEWYRARIVKVDGEQlyeVFFIDYGNEeVVPPSDLRQLPEE 56
Tudor_TDRD15_rpt3 cd20438
third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 1333-1464 8.19e-10

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410509  Cd Length: 141  Bit Score: 59.02  E-value: 8.19e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1333 AYATVIDGPEYFWCQFADseklqyLETEVQSAGKQLSDRRSCT-------QCPQIGDPCIVRYREDGHYYRALITNICDG 1405
Cdd:cd20438      9 AFVEYVLNPSNFWIRTDE------YNNEFQALMKNIADIYNLCgndeellKKPEPGLLCCARYSKDRHYYRAVITEVLDL 82

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1276740342 1406 ELaSVRLVDFGNAE--DCVDAKELWSIPSELllvPMQAFPCCLAGFSVSGGVCPQEGNDYF 1464
Cdd:cd20438     83 KV-SVYFLDFGNTDtvPFYDVKTLLPEFSEL---PALAMCCSLAHVFPVEEVWTKNANDFF 139
Tudor_TDRD6_rpt6 cd20425
sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 1333-1446 1.18e-09

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410496  Cd Length: 115  Bit Score: 57.85  E-value: 1.18e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1333 AYATVIDGPEYFWCQFADSEKLQYLETEVQSAGKQLSDRRSCtQCPQIGDPCIVRYREDGHYYRALITNICDGELASVRL 1412
Cdd:cd20425      4 VYVSHVNSPSDFYVQLAQDEDELSMISEKLNASKANDEEVEC-ESLQLGDLICAEYPEDGLWYRAVVKEKIPNNLVSVQF 82

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1276740342 1413 VDFGNAEDcVDAKELWSIPSELLLVPMQAFPCCL 1446
Cdd:cd20425     83 IDYGNTSV-VQPSKIHRLPKELLSIPALSIHCFL 115
Tudor_TDRD6_rpt5 cd20424
fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 1334-1446 1.25e-09

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410495  Cd Length: 126  Bit Score: 57.90  E-value: 1.25e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1334 YATVIDGPEYFWCQFA-DSEKLQYLetevQSAGKQLSDRRSCTQCPQI-GDPCIVRYrEDGHYYRALItnICDGELASVR 1411
Cdd:cd20424     17 YITYVNDPWTFYCQLArNAGVLDQL----ASAISRLSSEIRKLELSVNpGTLCLAKY-SDQHWYRGII--ITNKNSTEVF 89

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1276740342 1412 LVDFGNAEdCVDAKELWSIPS---ELLLVPMQAFPCCL 1446
Cdd:cd20424     90 FVDYGNTE-KVEKEDMLPIPSdayELLLLPMQAIKCSL 126
Tudor_TDRD6_rpt7 cd20426
seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 803-912 1.65e-09

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410497  Cd Length: 140  Bit Score: 57.89  E-value: 1.65e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  803 YVTHADDPWTFYCQLArnTNVLEQLSYNIMQLSK--ALLNLKASTLAPGTLCLARYT-DGNWYRGII--IEKEPSKVFFV 877
Cdd:cd20426      4 YATAVDSPEYFWCQFA--TEKIQCLAVKVQEAGEqvADRGNFIPSIYVGDPCIVKYSeDNHWYRALVtkINDNLVSVRFV 81

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1276740342  878 DFGNTY-IAVDHLLPIPRdahDVLLLPMQALKCSLS 912
Cdd:cd20426     82 DYGNEEdVVREQVRALPS---ELLKIPVQAFPCCLS 114
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
 848-892 1.79e-09

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 54.83  E-value: 1.79e-09
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1276740342  848 PGTLCLARYT-DGNWYRGIIIEKEPS---KVFFVDFGNT-YIAVDHLLPI 892
Cdd:cd20379      1 VGDLCAAKYEeDGKWYRARVLEVLSNdkvEVFFVDYGNTeTVPLSDLRPL 50
Tudor_TDRD1_rpt3 cd20410
third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 1169-1209 1.84e-09

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410481 [Multi-domain]  Cd Length: 59  Bit Score: 55.43  E-value: 1.84e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1276740342 1169 GDVICAVFPEDNLWYRALVMEQQPNGLLSVQFIDYGNMSVV 1209
Cdd:cd20410      6 GEPCCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNVEEV 46
Tudor_TDRD6_rpt2 cd20421
second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 787-881 2.08e-09

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410492  Cd Length: 130  Bit Score: 57.43  E-value: 2.08e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  787 YYYSthDLKIGSEELVYVTHADDPWTFYCQLARNTNVLEQLSYNIMQL--SKALLNLKASTLAPGTLCLARYTDGNWYRG 864
Cdd:cd20421      2 YFYP--QLQVGVTETVVVTEVTDPHRIFCQLRSLSQELKRLSESMHQYyeGRVGSGYETRPEKLGSPCAARGSDGRWYRA 79

                           90       100
                   ....*....|....*....|.
gi 1276740342  865 IIIEKEPSK----VFFVDFGN 881
Cdd:cd20421     80 VLQQVFSANrvveVLHVDYGR 100
Tudor_TDRD15_rpt4 cd20439
fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 789-914 2.26e-09

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410510  Cd Length: 125  Bit Score: 57.12  E-value: 2.26e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  789 YSTHDLKIGSEELVYVTHADDPWTFYCQLARNTNVLEQLsyniMQLSKALLNLKASTLAPG-TLCLARYT-DGNWYRGII 866
Cdd:cd20439      1 YKEYLFKPGSVVDVKCSYVNSPGDFWCQLQTKSSELKSL----MKQIQSYYLIHNDPYKHGqIACVAKYSkDGKWYRAAV 76

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1276740342  867 IEKEPSK---VFFVDFGNT-YIAVDHLLPI-PRdahdVLLLPMQALKCSLSDI 914
Cdd:cd20439     77 LKQVSAKevdVIFVDYGNQeRVLISDLRAIkPQ----FLLLEGQAFRCSLNNF 125
Tudor_TDRD15_rpt6 cd20441
sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 809-914 2.43e-09

sixth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410512  Cd Length: 108  Bit Score: 56.67  E-value: 2.43e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  809 DPWTFYCQLARNTNVLEQLSYNIMQLSKALLNLKASTLAPGTLCLARYT-DGNWYRGIIIEKEPSKVF---FVDFGNTYI 884
Cdd:cd20441      1 SPSRFFIQLSEDEKVILQLAEELNETSEKSRENAAVKLKVGDLVAAEYDeDLALYRAVITAVLPGKSFkveFIDYGNTAV 80

                           90       100       110
                   ....*....|....*....|....*....|....
gi 1276740342  885 aVD----HLLPiprdaHDVLLLPMQALKCSLSDI 914
Cdd:cd20441     81 -VDksniYTLQ-----EKFLSLPRLSIPCSLSGV 108
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 1164-1219 3.62e-09

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 54.20  E-value: 3.62e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....*.
gi 1276740342  1164 PQWQSGDVICAVFpEDNLWYRALVMEQQPNGLLSVQFIDYGNMSVVHTNRTGRLGP 1219
Cdd:smart00333    1 PTFKVGDKVAARW-EDGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDLRQLPE 55
Tudor_TDRD1_rpt1 cd20408
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 588-703 4.29e-09

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410479  Cd Length: 130  Bit Score: 56.61  E-value: 4.29e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  588 VSHIENPGSFWCQLM--RNAQGFRTLMCDIED-YCKSSEPSPYEGDT-RVCLAKRTASGRWSRALI-SGAHSLEHVRVVF 662
Cdd:cd20408      3 VTEFKNPGEFYIQIYtlEVLESLVKLTSQLKKtYASVNNHKEYIPEVgEVCVAKYSEDQNWYRALVqTVDVQQKKAGVFY 82

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1276740342  663 VDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSLYNLIQPMG 703
Cdd:cd20408     83 IDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSG 123
Tudor_TDRD1_rpt1 cd20408
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 1336-1448 4.37e-09

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410479  Cd Length: 130  Bit Score: 56.61  E-value: 4.37e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1336 TVID--GPEYFWCQFADSEKLQYLeTEVQSagkQLSDRRSCTQC-----PQIGDPCIVRYREDGHYYRALITNI-CDGEL 1407
Cdd:cd20408      2 TVTEfkNPGEFYIQIYTLEVLESL-VKLTS---QLKKTYASVNNhkeyiPEVGEVCVAKYSEDQNWYRALVQTVdVQQKK 77

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1276740342 1408 ASVRLVDFGNAEDcVDAKELWSIPSELLLVPMQAFPCCLAG 1448
Cdd:cd20408     78 AGVFYIDYGNEET-VPLNRIQPLKKDIELFPPCAIKCCLAN 117
Tudor_TDRD1_rpt1 cd20408
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 1122-1241 1.14e-08

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410479  Cd Length: 130  Bit Score: 55.45  E-value: 1.14e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1122 VYVSHINDLSDFYIQLIEDEA--EINNLSERLNDVRTRPQYHTGPQWQSGDVICAVFPEDNLWYRALVME-QQPNGLLSV 1198
Cdd:cd20408      1 GTVTEFKNPGEFYIQIYTLEVleSLVKLTSQLKKTYASVNNHKEYIPEVGEVCVAKYSEDQNWYRALVQTvDVQQKKAGV 80

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1276740342 1199 QFIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSLWGLSVPVC 1241
Cdd:cd20408     81 FYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSG 123
Tudor_TDRD15_rpt4 cd20439
fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 1109-1236 1.17e-08

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410510  Cd Length: 125  Bit Score: 55.19  E-value: 1.17e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1109 FPQKTIAPGFKTSVYVSHINDLSDFYIQLIEDEAEINNLSErlnDVRTRPQYHTGPqWQSGDVIC-AVFPEDNLWYRALV 1187
Cdd:cd20439      1 YKEYLFKPGSVVDVKCSYVNSPGDFWCQLQTKSSELKSLMK---QIQSYYLIHNDP-YKHGQIACvAKYSKDGKWYRAAV 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1276740342 1188 MEQQPNGLLSVQFIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSLWGL 1236
Cdd:cd20439     77 LKQVSAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125
Tudor_TDRD1_rpt4 cd20411
fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 586-695 1.25e-08

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410482  Cd Length: 116  Bit Score: 54.76  E-value: 1.25e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  586 VKVSHIENPGSFWC---QLMRNAQGFRTLMCDIEDYC-KSSEPSPYE---GDtrVCLAKRTASGRWSRALISGAhSLEHV 658
Cdd:cd20411      1 ALVLEVISPDLFYAlpkTGQVNVEKLKALMTELAEYCsKQSVPQQFRpriGD--ACCARFTGDKNWYRAVVLET-SDSEV 77

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1276740342  659 RVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSL 695
Cdd:cd20411     78 KVLYADYGNTETLPLSRILPITKSHLELPFQIIRCSL 114
Tudor_TDRD6_rpt3 cd20422
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 1122-1248 1.29e-08

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410493  Cd Length: 135  Bit Score: 55.21  E-value: 1.29e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1122 VYVSHINDLSDFYIQLIEDEAEINNLSERLNDVRTRPQYHTG----PQwqSGDVICAVFpEDNLWYRALVMEQQPNGLlS 1197
Cdd:cd20422      4 AQVEFVKDPSEFWIRLGEHAVPFSKLMRSMTAFYSQASKLDGvvlkPQ--PGQLCCAKW-KEDRYYRAIVTAVKGKMV-E 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1276740342 1198 VQFIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSL---WGLSVPVCKEMVSYF 1248
Cdd:cd20422     80 VFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLadiCPLGERWSPEAISAF 133
Tudor_TDRD4_rpt2 cd20415
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 849-914 1.89e-08

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410486  Cd Length: 96  Bit Score: 53.59  E-value: 1.89e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  849 GTLCLARYTDGNWYRGIII---EKEPSKVFFVDFGNT-YIAVDHLLPIPRDAhdvLLLPMQALKCSLSDI 914
Cdd:cd20415     28 GQACVALFEDGAWYRARIIglpGHREVEVKYVDFGNTaTVTIKHVRKIKDDF---LSLPEKARECRLAFI 94
Tudor_TDRD6_rpt6 cd20425
sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 801-911 2.57e-08

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410496  Cd Length: 115  Bit Score: 54.00  E-value: 2.57e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  801 LVYVTHADDPWTFYCQLARNTNVLEQLS--YNIMQLSKALLNLKAstLAPGTLCLARYT-DGNWYRGIIIEKEPSK---V 874
Cdd:cd20425      3 EVYVSHVNSPSDFYVQLAQDEDELSMISekLNASKANDEEVECES--LQLGDLICAEYPeDGLWYRAVVKEKIPNNlvsV 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1276740342  875 FFVDFGNT-YIAVDHLLPIPRDAhdvLLLPMQALKCSL 911
Cdd:cd20425     81 QFIDYGNTsVVQPSKIHRLPKEL---LSIPALSIHCFL 115
Tudor_TDRD1_rpt4 cd20411
fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 848-912 2.63e-08

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410482  Cd Length: 116  Bit Score: 53.99  E-value: 2.63e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1276740342  848 PGTLCLARYT-DGNWYRGIIIEKEPS--KVFFVDFGNTYI-AVDHLLPIpRDAHdvLLLPMQALKCSLS 912
Cdd:cd20411     50 IGDACCARFTgDKNWYRAVVLETSDSevKVLYADYGNTETlPLSRILPI-TKSH--LELPFQIIRCSLA 115
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
 312-361 2.74e-08

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 51.75  E-value: 2.74e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1276740342  312 PGSPCASC-GLDGQWYRALLLETFRPQRCaQVLHVDYGRKELVSCSSLRYL 361
Cdd:cd20379      1 VGDLCAAKyEEDGKWYRARVLEVLSNDKV-EVFFVDYGNTETVPLSDLRPL 50
Tudor_TDRD1_rpt1 cd20408
first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 253-388 5.04e-08

first Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410479  Cd Length: 130  Bit Score: 53.53  E-value: 5.04e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  253 VVVTQVCHPHRIHCQLRSLS--QEIHRLSESMAQVYRAPVGtddedsgsatweEREESPDKpGSPC-ASCGLDGQWYRAL 329
Cdd:cd20408      1 GTVTEFKNPGEFYIQIYTLEvlESLVKLTSQLKKTYASVNN------------HKEYIPEV-GEVCvAKYSEDQNWYRAL 67

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1276740342  330 LLETFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYGLWDCGRGWS 388
Cdd:cd20408     68 VQTVDVQQKKAGVFYIDYGNEETVPLNRIQPLKKDIELFPPCAIKCCLANVKPPSGSWS 126
Tudor_TDRD1_rpt2 cd20409
second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 1146-1219 6.49e-08

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410480  Cd Length: 82  Bit Score: 51.69  E-value: 6.49e-08
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1276740342 1146 NLSERLNDVRTRPQYHTGPqwqsGDVICAVFPEDNLWYRALVMEQQPNGLLSVQFIDYGNMSVVHTNRTGRLGP 1219
Cdd:cd20409     10 SLSAYCKVAPASSDFSPAV----GEVCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGNSEEVALSRLRPIPP 79
Tudor_TDRD6_rpt5 cd20424
fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 1114-1233 7.47e-08

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410495  Cd Length: 126  Bit Score: 52.89  E-value: 7.47e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1114 IAPGFKTSVYVSHINDLSDFYIQLIEDEAEINNLSERLNDVRTRPQYHTGPQwQSGDVICAVFpEDNLWYRALVMEQQPN 1193
Cdd:cd20424      8 IKIGSEEEVYITYVNDPWTFYCQLARNAGVLDQLASAISRLSSEIRKLELSV-NPGTLCLAKY-SDQHWYRGIIITNKNS 85

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1276740342 1194 glLSVQFIDYGNMSVVHTNRTGRLgPVDA----VLPALCLHCSL 1233
Cdd:cd20424     86 --TEVFFVDYGNTEKVEKEDMLPI-PSDAyellLLPMQAIKCSL 126
Tudor_TDRD15_rpt4 cd20439
fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 245-380 7.59e-08

fourth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410510  Cd Length: 125  Bit Score: 52.88  E-value: 7.59e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  245 LQLGVTEPVVVTQVCHPHRIHCQLRSLSQEIHRLSESMAQVYrapvgtddedsgsatweEREESPDKPG-SPC-ASCGLD 322
Cdd:cd20439      6 FKPGSVVDVKCSYVNSPGDFWCQLQTKSSELKSLMKQIQSYY-----------------LIHNDPYKHGqIACvAKYSKD 68

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1276740342  323 GQWYRALLLeTFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYGL 380
Cdd:cd20439     69 GKWYRAAVL-KQVSAKEVDVIFVDYGNQERVLISDLRAIKPQFLLLEGQAFRCSLNNF 125
Tudor_TDRD1_rpt4 cd20411
fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 316-379 8.42e-08

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410482  Cd Length: 116  Bit Score: 52.45  E-value: 8.42e-08
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1276740342  316 CASCGLDGQWYRALLLETfrPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYG 379
Cdd:cd20411     55 CARFTGDKNWYRAVVLET--SDSEVKVLYADYGNTETLPLSRILPITKSHLELPFQIIRCSLAG 116
Tudor_TDRD6_rpt3 cd20422
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 802-914 1.14e-07

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410493  Cd Length: 135  Bit Score: 52.51  E-value: 1.14e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  802 VYVTHADDPWTFYCQLARNTNVLEQLSYNIMQLSKALLNLKASTLAP--GTLCLARYTDGNWYRGII--IEKEPSKVFFV 877
Cdd:cd20422      4 AQVEFVKDPSEFWIRLGEHAVPFSKLMRSMTAFYSQASKLDGVVLKPqpGQLCCAKWKEDRYYRAIVtaVKGKMVEVFLV 83

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1276740342  878 DFGNT----YIAVDHLLPIPRDahdvllLPMQALKCSLSDI 914
Cdd:cd20422     84 DRGNTemvdWYDVKKLLPQFRE------LPALALKCCLADI 118
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
 633-676 1.75e-07

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 49.44  E-value: 1.75e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 1276740342  633 VCLAKRTASGRWSRALISGAHSLEHVRVVFVDYGDRDVVSTKDI 676
Cdd:cd20379      4 LCAAKYEEDGKWYRARVLEVLSNDKVEVFFVDYGNTETVPLSDL 47
Tudor_TDRD15_rpt3 cd20438
third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 588-717 2.21e-07

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410509  Cd Length: 141  Bit Score: 52.09  E-value: 2.21e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  588 VSHIENPGSFWCQLMRNAQGFRTLMCDIEDY---CKSSE---PSPYEGDtrVCLAKRTASGRWSRALISGAHSLeHVRVV 661
Cdd:cd20438     11 VEYVLNPSNFWIRTDEYNNEFQALMKNIADIynlCGNDEellKKPEPGL--LCCARYSKDRHYYRAVITEVLDL-KVSVY 87

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1276740342  662 FVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSLYNlIQPMGEnpfVWDEKAVQAF 717
Cdd:cd20438     88 FLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSLAH-VFPVEE---VWTKNANDFF 139
Tudor_TDRD11 cd20433
Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, ...
 1169-1219 2.44e-07

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410504 [Multi-domain]  Cd Length: 84  Bit Score: 49.99  E-value: 2.44e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1276740342 1169 GDVICAVFPEDNLWYRALVMEQQPNGLLSVQFIDYGNMSVVHTNRTGRLGP 1219
Cdd:cd20433     31 GDLCAAKFVEDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPSTRLAALPP 81
Tudor_TDRD4_rpt2 cd20415
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 1354-1447 3.85e-07

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410486  Cd Length: 96  Bit Score: 49.74  E-value: 3.85e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1354 LQYLETEVQSAGKQLSDRRSCTQCPQIGDPCIVRYrEDGHYYRALITNICDGELASVRLVDFGNaEDCVDAKELWSIPSE 1433
Cdd:cd20415      1 FLILTKKIQEFYKEGDDGGLEILCPVQGQACVALF-EDGAWYRARIIGLPGHREVEVKYVDFGN-TATVTIKHVRKIKDD 78

                           90
                   ....*....|....
gi 1276740342 1434 LLLVPMQAFPCCLA 1447
Cdd:cd20415     79 FLSLPEKARECRLA 92
Tudor_TDRD2 cd20412
Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, ...
 1167-1204 4.29e-07

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410483  Cd Length: 95  Bit Score: 49.60  E-value: 4.29e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1276740342 1167 QSGDVICAVFPEDNLWYRALVMEQQPNGLLSVQFIDYG 1204
Cdd:cd20412     30 QVGDIVAAPFRHDGSWYRARVLGFLENGNLDLYFVDYG 67
Tudor_TDRD1_rpt3 cd20410
third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 848-895 4.43e-07

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410481 [Multi-domain]  Cd Length: 59  Bit Score: 48.49  E-value: 4.43e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1276740342  848 PGTLCLARYT-DGNWYRGIIIEKEPS---KVFFVDFGNTY-IAVDHLLPIPRD 895
Cdd:cd20410      5 VGEPCCAFFSgDGNWYRAMVKEILPGgavKVHFVDYGNVEeVTLDKLRKITST 57
Tudor_TDRD6_rpt3 cd20422
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 585-717 5.94e-07

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410493  Cd Length: 135  Bit Score: 50.59  E-value: 5.94e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  585 EVKVSHIENPGSFWCQLMRNAQGFRTLMCDIED-YCKSS-------EPSPyeGDtrVCLAKrTASGRWSRALISGAHSlE 656
Cdd:cd20422      3 DAQVEFVKDPSEFWIRLGEHAVPFSKLMRSMTAfYSQASkldgvvlKPQP--GQ--LCCAK-WKEDRYYRAIVTAVKG-K 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1276740342  657 HVRVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSLYNlIQPMGENpfvWDEKAVQAF 717
Cdd:cd20422     77 MVEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLAD-ICPLGER---WSPEAISAF 133
Tudor_ZGPAT cd20384
Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and ...
 844-892 6.59e-07

Tudor domain found in zinc finger CCCH-type with G patch domain-containing protein (ZGPAT) and similar proteins; ZGPAT, also called ZIP, G patch domain-containing protein 6 (GPATC6), GPATCH6, zinc finger CCCH domain-containing protein 9 (ZC3HDC9), ZC3H9, or zinc finger and G patch domain-containing protein, is a transcription repressor that specifically binds the 5'-GGAG[GA]A[GA]A-3' consensus sequence. It represses transcription by recruiting the chromatin multiprotein complex NuRD to target promoters. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410455  Cd Length: 55  Bit Score: 47.99  E-value: 6.59e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1276740342  844 STLAPGTLCLARYTDGNWYRGIIIEKEPSKVFFVDF--GNTYIAV--DHLLPI 892
Cdd:cd20384      3 SSLKEGSRCLAKYDDGLWYPATVTDIDEDGKYTVKFdsYGEVAVVelDDILPL 55
Tudor_TDRD15_rpt5 cd20440
fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 245-353 7.60e-07

fifth Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410511  Cd Length: 127  Bit Score: 50.15  E-value: 7.60e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  245 LQLGVTEPVVVTQVCHPHRIHCQLRSLSQEIHRLSESMAQVYRAPVGTDDEdsgsatweereesPDKPGSPCASCGLDGQ 324
Cdd:cd20440      6 IKVGSEEEVYITHVYSPAKFYCQLDRNTEILEALMEKIAEISKLFNSQILD-------------NCKTRLCLAKYFEDGQ 72

                           90       100
                   ....*....|....*....|....*....
gi 1276740342  325 WYRALLLETFRPQRcAQVLHVDYGRKELV 353
Cdd:cd20440     73 WYRALAHPVESSSH-LSVYFVDYGNKQIV 100
Tudor_TDRD15_rpt3 cd20438
third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 794-922 8.33e-07

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410509  Cd Length: 141  Bit Score: 50.17  E-value: 8.33e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  794 LKIGSEELVYVTHADDPWTFYCQLARNTNVLEQLS------YNIMQLSKALLNlkasTLAPGTLCLARYT-DGNWYRGII 866
Cdd:cd20438      1 MEVDAAYVAFVEYVLNPSNFWIRTDEYNNEFQALMkniadiYNLCGNDEELLK----KPEPGLLCCARYSkDRHYYRAVI 76

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1276740342  867 IEKEPSK--VFFVDFGNTYIA----VDHLLPiprdahDVLLLPMQALKCSLSdipHHIP-EEV 922
Cdd:cd20438     77 TEVLDLKvsVYFLDFGNTDTVpfydVKTLLP------EFSELPALAMCCSLA---HVFPvEEV 130
Tudor_TDRD7_rpt2 cd20428
second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
 586-715 9.90e-07

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410499  Cd Length: 140  Bit Score: 50.14  E-value: 9.90e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  586 VKVSHIENPGSFWCQL-MRNAQGFRTLMCDIEDYCKSSEPS-------PYEGdtRVCLAKrtASGRWSRALISGAHSLEH 657
Cdd:cd20428      4 VRVTNVCSDGTLYCQVpSKGLSKLNEILDKIEYYFHSRQMTseyfvslPFCG--KICLAR--YKGKWARVEITNVHSSRA 79

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1276740342  658 VRVVFVDYGDRDVVSTKDILSVSDVFFQ----VRAQAFRCSLYNLIQPMGenpfVWDEKAVQ 715
Cdd:cd20428     80 LDVHFLDTGTVASVKVSELREIPPPFLRelisIPPQALKCCLADLPLNIG----MWTPDAVL 137
Tudor_TDRD6_rpt4 cd20423
fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 848-914 1.11e-06

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410494  Cd Length: 80  Bit Score: 48.25  E-value: 1.11e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1276740342  848 PGTLCLARYT-DGNWYRGIIIE----KEPSKVFFVDFGNTYI-AVDHLLPIprdAHDVLLLPMQALKCSLSDI 914
Cdd:cd20423      5 PNPVCLAKYSeDGKWCRALIDNvyepVEMVEVTYVDYGNKELvSLKNLRSI---SEEFLKLKAQAFRCSLYNL 74
Tudor_TDRD7_rpt2 cd20428
second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
 802-925 1.17e-06

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410499  Cd Length: 140  Bit Score: 49.75  E-value: 1.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  802 VYVTHADDPWTFYCQ-----LARNTNVLEQLSY--NIMQLSKALLnlkASTLAPGTLCLARYTdGNWYRGIIIEKEPSK- 873
Cdd:cd20428      4 VRVTNVCSDGTLYCQvpskgLSKLNEILDKIEYyfHSRQMTSEYF---VSLPFCGKICLARYK-GKWARVEITNVHSSRa 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1276740342  874 --VFFVDFGN-TYIAVDHLLPIP-RDAHDVLLLPMQALKCSLSDIPHHI---PEEVTAW 925
Cdd:cd20428     80 ldVHFLDTGTvASVKVSELREIPpPFLRELISIPPQALKCCLADLPLNIgmwTPDAVLW 138
Tudor_TDRD4_rpt5 cd20418
fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 1380-1449 1.87e-06

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410489  Cd Length: 105  Bit Score: 48.17  E-value: 1.87e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1276740342 1380 IGDPCIVRYReDGHYYRALITNICDGELAS--VRLVDFGnAEDCVDAKELWSIPSELLLVPMQAFPCCLAGF 1449
Cdd:cd20418      6 PEMPCLAEYS-DGKWYRAKLLSILEFNPVKilVRHVDYG-STAALPTSRLRQIPAELMQYPCQAIKVKLAGF 75
Tudor_TDRD4_rpt5 cd20418
fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 848-911 3.41e-06

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410489  Cd Length: 105  Bit Score: 47.40  E-value: 3.41e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  848 PGTLCLARYTDGNWYRGIII---EKEPSKVF--FVDFGNT-YIAVDHLLPIPRdahDVLLLPMQALKCSL 911
Cdd:cd20418      6 PEMPCLAEYSDGKWYRAKLLsilEFNPVKILvrHVDYGSTaALPTSRLRQIPA---ELMQYPCQAIKVKL 72
Tudor_TDRD7_rpt2 cd20428
second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
 1339-1459 5.12e-06

second Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410499  Cd Length: 140  Bit Score: 47.82  E-value: 5.12e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1339 DGPEYfwCQFAdSEKLQYLETEVQSAGKQLSDRRSCTQC----PQIGDPCIVRYRedGHYYRALITNICDGELASVRLVD 1414
Cdd:cd20428     12 DGTLY--CQVP-SKGLSKLNEILDKIEYYFHSRQMTSEYfvslPFCGKICLARYK--GKWARVEITNVHSSRALDVHFLD 86

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*....
gi 1276740342 1415 FGNAEDcVDAKELWSIPS----ELLLVPMQAFPCCLAGFSVSGGVCPQE 1459
Cdd:cd20428     87 TGTVAS-VKVSELREIPPpflrELISIPPQALKCCLADLPLNIGMWTPD 134
Tudor_TDRD11 cd20433
Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, ...
 849-893 6.08e-06

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410504 [Multi-domain]  Cd Length: 84  Bit Score: 46.14  E-value: 6.08e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1276740342  849 GTLCLARYT-DGNWYRGIIIEKEPSK---VFFVDFGNT-YIAVDHLLPIP 893
Cdd:cd20433     31 GDLCAAKFVeDGEWYRAKVEKVEGDKkvhVLYIDYGNReVLPSTRLAALP 80
Tudor_TDRD15_rpt1 cd20436
first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 1326-1464 7.12e-06

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410507  Cd Length: 147  Bit Score: 47.80  E-value: 7.12e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1326 PKAKLIKayatvidgpeyFWCQFADSEKLQY--LETEVQSAGKQLSdrrsctqCPQIGDPCIVRYREDGHYYRALITNIC 1403
Cdd:cd20436     11 PKEVLVK-----------FQGQYNSICELDYhiLQNEIQNATKSKS-------SWGVGEFCLVEDTTSGEWYRGRVLEKI 72

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1276740342 1404 DgELASVRLVDFGNAEDcVDAKELWSIPSELLLVPMQAFPCCLAGFSVSGGVCPQEGNDYF 1464
Cdd:cd20436     73 D-EKYEVFLIDRGEVLN-VHATNMASASGELFQLPPKAVCGIFANILPIGEKWSSTAVNYF 131
Tudor_TDRD9 cd20431
Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is ...
 820-890 8.38e-06

Tudor domain found in Tudor domain-containing protein 9 (TDRD9) and similar proteins; TDRD9 is an ATP-dependent DEAD-like RNA helicase required during spermatogenesis. It is involved in the biosynthesis of PIWI-interacting RNAs (piRNAs). A recessive deleterious mutation mutation in TDRD9 causes non-obstructive azoospermia in infertile men. TDRD9 contains an N-terminal HrpA-like RNA helicase module and a Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410502  Cd Length: 101  Bit Score: 46.23  E-value: 8.38e-06
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1276740342  820 NTNVLEQLSYNIMQLSkaLLNLKAStLAPGTLCLARYTDGN---WYRGIIIEKEPS--KVFFVDFGNTYIAVDHLL 890
Cdd:cd20431     18 SSEILQQLTAEINQRQ--LVPLTTK-PVPNLLCLAPFTDADmkkYYRAKILYVSGSsaEVFFVDYGNTSQVPSSLL 90
Tudor_TDRD15_rpt1 cd20436
first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 633-723 1.25e-05

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410507  Cd Length: 147  Bit Score: 47.03  E-value: 1.25e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  633 VCLAKRTASGRWSRALISgAHSLEHVRVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSLYNlIQPMGEnpfVWDEK 712
Cdd:cd20436     52 FCLVEDTTSGEWYRGRVL-EKIDEKYEVFLIDRGEVLNVHATNMASASGELFQLPPKAVCGIFAN-ILPIGE---KWSST 126

                           90
                   ....*....|.
gi 1276740342  713 AVQAFSGFIDS 723
Cdd:cd20436    127 AVNYFSSLIGS 137
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 624-676 1.34e-05

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 44.19  E-value: 1.34e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1276740342   624 PSPYEGDtrVCLAKRTaSGRWSRALISGAHSLEHVRVVFVDYGDRDVVSTKDI 676
Cdd:smart00333    1 PTFKVGD--KVAARWE-DGEWYRARIVKVDGEQLYEVFFIDYGNEEVVPPSDL 50
Tudor_SPF30 cd20399
Tudor domain found in survival of motor neuron-related-splicing factor 30 (SPF30) and similar ...
 1379-1421 1.40e-05

Tudor domain found in survival of motor neuron-related-splicing factor 30 (SPF30) and similar proteins; SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. Overexpression of SPF30 causes apoptosis. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410470 [Multi-domain]  Cd Length: 55  Bit Score: 44.22  E-value: 1.40e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1276740342 1379 QIGDPCIVRYREDGHYYRALITNICDGELASVRLVDFGNAEDC 1421
Cdd:cd20399      2 KVGDKCMAVWSEDGQYYEATIEEISEDGTCTVTFDGYGNTEVT 44
Tudor_TDRD6_rpt3 cd20422
third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 311-396 1.51e-05

third Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410493  Cd Length: 135  Bit Score: 46.35  E-value: 1.51e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  311 KPGSPCASCGLDGQWYRALLLETfrPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYGLWDCGRGWSRS 390
Cdd:cd20422     51 QPGQLCCAKWKEDRYYRAIVTAV--KGKMVEVFLVDRGNTEMVDWYDVKKLLPQFRELPALALKCCLADICPLGERWSPE 128


                   ....*.
gi 1276740342  391 QVGDLK 396
Cdd:cd20422    129 AISAFK 134
Tudor_TDRD6_rpt7 cd20426
seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 1123-1248 1.73e-05

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410497  Cd Length: 140  Bit Score: 46.34  E-value: 1.73e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1123 YVSHINDLSDFYIQLIEDEaeINNLSERLNDVRTRPQyHTG---PQWQSGDVICAVFPEDNLWYRALVMEQQPNgLLSVQ 1199
Cdd:cd20426      4 YATAVDSPEYFWCQFATEK--IQCLAVKVQEAGEQVA-DRGnfiPSIYVGDPCIVKYSEDNHWYRALVTKINDN-LVSVR 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1276740342 1200 FIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSLWG--LSVPVCK-EMVSYF 1248
Cdd:cd20426     80 FVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSGfnLSEGLWSdEANDYF 131
Tudor_TDRD15_rpt2 cd20437
second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 1340-1447 1.75e-05

second Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410508  Cd Length: 120  Bit Score: 45.87  E-value: 1.75e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1340 GPEYFWCQFADSEK-LQYLETEVQSAGKQLSDRRSCTqCPQIGDPCIVRyREDGHYYRALITNICDGELASVRLVDFGNA 1418
Cdd:cd20437     14 SPSKFYCQLLSWEPeLSKLTTQMTLHYESVSKELNPS-CENFGLLCAAK-GKDGQWHRGFLQQLLPPSQVKVWFIDYGNS 91

                           90       100
                   ....*....|....*....|....*....
gi 1276740342 1419 EdCVDAKELWSIPSELLLVPMQAFPCCLA 1447
Cdd:cd20437     92 E-AVSSHSVLKLPPDFFSLPLMSFPCSLS 119
Tudor_TDRD3 cd20413
Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is ...
 1381-1420 1.81e-05

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410484  Cd Length: 53  Bit Score: 43.87  E-value: 1.81e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1276740342 1381 GDPCIVRYREDGHYYRALITNIC-DGELASVRLVDFGNAED 1420
Cdd:cd20413      4 GDECLAKYWEDNKFYRAEVTAVHpSGKTAVVKFMEYGNYEE 44
Tudor_TDRD6_rpt5 cd20424
fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 240-353 1.90e-05

fifth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410495  Cd Length: 126  Bit Score: 45.96  E-value: 1.90e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  240 YFYPQ--LQLGVTEPVVVTQVCHPHRIHCQLRSLSQEIHRLSESMAQVyrapvgtddedsgsATWEEREESPDKPGSPCA 317
Cdd:cd20424      1 YYYSMhdIKIGSEEEVYITYVNDPWTFYCQLARNAGVLDQLASAISRL--------------SSEIRKLELSVNPGTLCL 66

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1276740342  318 SCGLDGQWYRALLLETFRPQrcaQVLHVDYGRKELV 353
Cdd:cd20424     67 AKYSDQHWYRGIIITNKNST---EVFFVDYGNTEKV 99
Tudor_TDRD11 cd20433
Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, ...
 321-366 2.07e-05

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410504 [Multi-domain]  Cd Length: 84  Bit Score: 44.60  E-value: 2.07e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1276740342  321 LDGQWYRALLlETFRPQRCAQVLHVDYGRKELVSCSSLRYLLPEYF 366
Cdd:cd20433     40 EDGEWYRAKV-EKVEGDKKVHVLYIDYGNREVLPSTRLAALPPAFS 84
Tudor_TDRD2 cd20412
Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, ...
 1359-1444 2.63e-05

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410483  Cd Length: 95  Bit Score: 44.59  E-value: 2.63e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1359 TEVQSAGKQLSDRRSctqcPQIGDPCIVRYREDGHYYRALITNICDGELASVRLVDFGNAEDcVDAKELWSIPSELLLVP 1438
Cdd:cd20412     14 TQYYESEENRHTLLT----VQVGDIVAAPFRHDGSWYRARVLGFLENGNLDLYFVDYGDSGY-VPLEDLRALRSDFLSLP 88


                   ....*.
gi 1276740342 1439 MQAFPC 1444
Cdd:cd20412     89 FQAIEC 94
Tudor_SMN_SPF30-like cd21182
Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing ...
 1381-1430 2.89e-05

Tudor domain found in survival motor neuron protein (SMN), motor neuron-related-splicing factor 30 (SPF30), and similar proteins; This group contains SMN, SPF30, Tudor domain-containing protein 3 (TDRD3), DNA excision repair protein ERCC-6-like 2 (ERCC6L2), and similar proteins. SMN, also called component of gems 1, or Gemin-1, is part of a multimeric SMN complex that includes spliceosomal Sm core proteins and plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. ERCC6L2, also called DNA repair and recombination protein RAD26-like (RAD26L), may be involved in early DNA damage response. It regulates RNA Pol II-mediated transcription via its interaction with DNA-dependent protein kinase (DNA-PK) to resolve R loops and minimize transcription-associated genome instability. Members of this group contain a single Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410549  Cd Length: 50  Bit Score: 43.01  E-value: 2.89e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1276740342 1381 GDPCIVRYREDGHYYRALITNI-CDGELASVRLVDFGNAEDcVDAKELWSI 1430
Cdd:cd21182      1 GDKCLAPYSDDGKYYEATIEEItEESDTATVVFDGYGNSEE-VPLSDLKPL 50
Tudor_TDRD4_rpt5 cd20418
fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 312-377 3.13e-05

fifth Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the fifth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410489  Cd Length: 105  Bit Score: 44.71  E-value: 3.13e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1276740342  312 PGSPCASCGLDGQWYRALLL--ETFRPQRCAqVLHVDYGRKELVSCSSLRYLLPEYFRmpvvtYPCAL 377
Cdd:cd20418      6 PEMPCLAEYSDGKWYRAKLLsiLEFNPVKIL-VRHVDYGSTAALPTSRLRQIPAELMQ-----YPCQA 67
Tudor_TDRD6_rpt2 cd20421
second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 1336-1448 3.78e-05

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410492  Cd Length: 130  Bit Score: 45.11  E-value: 3.78e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1336 TVIDGPEYFWCQF-ADSEKLQYLETEVQSAGKQLSDRRSCTQCPQIGDPCIVRyREDGHYYRALITN-ICDGELASVRLV 1413
Cdd:cd20421     18 TEVTDPHRIFCQLrSLSQELKRLSESMHQYYEGRVGSGYETRPEKLGSPCAAR-GSDGRWYRAVLQQvFSANRVVEVLHV 96

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1276740342 1414 DFGNAEdCVDAKELWSIPSELLLVPMQAFPCCLAG 1448
Cdd:cd20421     97 DYGRKE-VVSVSNLRYLAPEYFRMPVVTYPCALFG 130
Tudor_TDRD11 cd20433
Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, ...
 1378-1434 3.79e-05

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410504 [Multi-domain]  Cd Length: 84  Bit Score: 43.83  E-value: 3.79e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1276740342 1378 PQIGDPCIVRYREDGHYYRALITNICDGELASVRLVDFGNAEDcVDAKELWSIPSEL 1434
Cdd:cd20433     28 PRKGDLCAAKFVEDGEWYRAKVEKVEGDKKVHVLYIDYGNREV-LPSTRLAALPPAF 83
Tudor_TDRD2 cd20412
Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, ...
 857-910 3.85e-05

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410483  Cd Length: 95  Bit Score: 44.21  E-value: 3.85e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1276740342  857 TDGNWYRGIIIEKEPSK---VFFVDFG-NTYIAVDHLLPIprdAHDVLLLPMQALKCS 910
Cdd:cd20412     41 HDGSWYRARVLGFLENGnldLYFVDYGdSGYVPLEDLRAL---RSDFLSLPFQAIECS 95
Tudor_TDRD11 cd20433
Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, ...
 610-676 4.06e-05

Tudor domain found in Tudor domain-containing protein 11 (TDRD11) and similar proteins; TDRD11, also called Staphylococcal nuclease domain-containing protein 1 (SND1), 100 kDa coactivator, EBNA2 coactivator p100, or p100 co-activator, is a multifunctional protein that is reportedly associated with different types of RNA molecules, including mRNA, miRNA, pre-miRNA, and dsRNA. It has been implicated in a number of biological processes in eukaryotic cells, including the cell cycle, DNA damage repair, proliferation, and apoptosis. TDRD11 is overexpressed in multiple cancers and functions as an oncogene. It contains multiple Staphylococcal nuclease (SN) domains and a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410504 [Multi-domain]  Cd Length: 84  Bit Score: 43.83  E-value: 4.06e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1276740342  610 TLMCDIEDYCKSSEPS-----PYEGDtrVCLAKRTASGRWSRALISGAHSLEHVRVVFVDYGDRDVVSTKDI 676
Cdd:cd20433      7 KLMEKLRFEIASNPPLpgsytPRKGD--LCAAKFVEDGEWYRAKVEKVEGDKKVHVLYIDYGNREVLPSTRL 76
Tudor_TDRD8 cd20430
Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, ...
 1174-1209 4.30e-05

Tudor domain found in Tudor domain-containing protein 8 (TDRD8) and similar proteins; TDRD8, also called serine/threonine-protein kinase (EC 2.7.11.1) 31 (STK31), serine/threonine-protein kinase NYD-SPK, or Sugen kinase 396 (SgK396), is a germ cell-specific factor expressed in embryonic gonocytes of both sexes, and in postnatal spermatocytes and round spermatids in males. It acts as a cell-cycle regulated protein that contributes to the tumorigenicity of epithelial cancer cells. TDRD8 contains a Tudor domain and a serine/threonine kinase domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410501 [Multi-domain]  Cd Length: 75  Bit Score: 43.43  E-value: 4.30e-05
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1276740342 1174 AVFPEDNLWYRALVMEQQPNGLLSVQFIDYGNMSVV 1209
Cdd:cd20430     27 GKFSEDNCWYRCKVKSILSDEKCTVQYIDYGNTETV 62
Tudor_TDRD1_rpt2 cd20409
second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 611-676 4.34e-05

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410480  Cd Length: 82  Bit Score: 43.60  E-value: 4.34e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  611 LMCDIEDYCK----SSEPSPYEGDtrVCLAKRTASGRWSRALISGAHSLEHVRVVFVDYGDRDVVSTKDI 676
Cdd:cd20409      7 LQESLSAYCKvapaSSDFSPAVGE--VCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGNSEEVALSRL 74
Tudor_AtTudor1-like cd20443
Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor ...
 813-914 4.77e-05

Tudor domain found in Arabidopsis thaliana ribonuclease Tudor 1 (AtTudor1), ribonuclease Tudor 2 (AtTudor2), and similar proteins; The family includes AtTudor1 (also called Tudor-SN protein 1) and AtTudor2 (also called Tudor-SN protein 2 or 100 kDa coactivator-like protein). They are cytoprotective ribonucleases (RNases) required for resistance to abiotic stresses, acting as positive regulators of mRNA decapping during stress. Members of this family contain one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410514 [Multi-domain]  Cd Length: 117  Bit Score: 44.76  E-value: 4.77e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  813 FYCQLARNTNVLeqlsyNIM-QLSKalLNLKASTLAP-------GTLCLARYT-DGNWYRGIIIE---------KEPSKV 874
Cdd:cd20443      4 FYVQVVSDQRLS-----SIQqQLEG--LSLKDKANPPggfnpkkGELVLAQFSaDNSWNRAMVVNaprqgtqspKDEYEV 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1276740342  875 FFVDFGNT-YIAVDHLLPIPrdaHDVLLLPMQALKCSLSDI 914
Cdd:cd20443     77 FYIDYGNQeTVPLSALRPLD---PSVSSAPGLAQLCSLAHI 114
Tudor_TDRD4_rpt2 cd20415
second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; ...
 608-695 5.30e-05

second Tudor domain found in Tudor domain-containing protein 4 (TDRD4) and similar proteins; TDRD4, also called RING finger protein 17 (RNF17), is a component of the mammalian germ cell nuage and is essential for spermiogenesis. It seems to be involved in the regulation of transcriptional activity of MYC. In vitro, TDRD4 inhibits the DNA-binding activity of Mad-MAX heterodimers. It can recruit Mad transcriptional repressors (MXD1, MXD3, MXD4 and MXI1) to the cytoplasm. TDRD4 also acts as a potential cancer/testis antigen in liver cancer. TDRD4 contains a RING finger and five Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410486  Cd Length: 96  Bit Score: 43.96  E-value: 5.30e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  608 FRTLMCDIED-YCKSSEPS-----PYEGdtRVCLAKRTaSGRWSRALISGAHSLEHVRVVFVDYGDRDVVSTKDILSVSD 681
Cdd:cd20415      1 FLILTKKIQEfYKEGDDGGleilcPVQG--QACVALFE-DGAWYRARIIGLPGHREVEVKYVDFGNTATVTIKHVRKIKD 77

                           90
                   ....*....|....
gi 1276740342  682 VFFQVRAQAFRCSL 695
Cdd:cd20415     78 DFLSLPEKARECRL 91
Tudor_TDRD6_rpt4 cd20423
fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 1172-1240 5.81e-05

fourth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410494  Cd Length: 80  Bit Score: 43.24  E-value: 5.81e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1276740342 1172 IC-AVFPEDNLWYRALVME-QQPNGLLSVQFIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSLWGLSVPV 1240
Cdd:cd20423      8 VClAKYSEDGKWCRALIDNvYEPVEMVEVTYVDYGNKELVSLKNLRSISEEFLKLKAQAFRCSLYNLIQPS 78
Tudor_TDRD5 cd20419
Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is ...
 1123-1233 6.17e-05

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410490  Cd Length: 118  Bit Score: 44.36  E-value: 6.17e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1123 YVSHINDLSDFYIQLIEDEAeinnlSERLNDVRTRPQ-YHTGPQ-----------WQSGDVICAVFPEDNLWYRALVMEQ 1190
Cdd:cd20419      1 FVEYIESPSQFYVRFYSKDT-----SEMLEDMMIEMRrCYSNEHvseryvmpeafIQPGQVCCVRIPEDVWWYRVIIHQV 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|...
gi 1276740342 1191 QPNGLLSVQFIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSL 1233
Cdd:cd20419     76 LNKQEVEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118
Tudor_TDRD6_rpt7 cd20426
seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 314-399 6.83e-05

seventh Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410497  Cd Length: 140  Bit Score: 44.80  E-value: 6.83e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  314 SPCASCG--------LDGQWYRALLLETfrPQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCALYGlWDCGR 385
Cdd:cd20426     44 IPSIYVGdpcivkysEDNHWYRALVTKI--NDNLVSVRFVDYGNEEDVVREQVRALPSELLKIPVQAFPCCLSG-FNLSE 120

                           90
                   ....*....|....*
gi 1276740342  386 G-WSRSQVGDLKALI 399
Cdd:cd20426    121 GlWSDEANDYFYEIV 135
Tudor_TDRD12_rpt2 cd20435
second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; ...
 1366-1447 1.10e-04

second Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the second/C-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410506  Cd Length: 134  Bit Score: 43.78  E-value: 1.10e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1366 KQLSDRRSCTQcPQIGDPCIVRYREDGhYYRALITNI--CDGE----LASVRLVDFGNAEDcVDAKELWSIPSELLLVPM 1439
Cdd:cd20435     39 SDPSNRILHGK-VKVGDLCAVEDENNL-YHRVKVLEIteKDDKtkprEVLVKFIDEGRVET-VVVSQLLELPEELKSLPP 115

                           90
                   ....*....|.
gi 1276740342 1440 QA---FPCCLA 1447
Cdd:cd20435    116 QAvevFLCNVK 126
Tudor_TDRD1_rpt4 cd20411
fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 1147-1235 1.11e-04

fourth Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the fourth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410482  Cd Length: 116  Bit Score: 43.59  E-value: 1.11e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1147 LSERLNDVRTRPQYHTGPqwqsGDVICAVFPEDNLWYRALVMEQQPNGlLSVQFIDYGNMSVVHTNRTGRLGPVDAVLPA 1226
Cdd:cd20411     33 LAEYCSKQSVPQQFRPRI----GDACCARFTGDKNWYRAVVLETSDSE-VKVLYADYGNTETLPLSRILPITKSHLELPF 107


                   ....*....
gi 1276740342 1227 LCLHCSLWG 1235
Cdd:cd20411    108 QIIRCSLAG 116
Tudor_TDRD6_rpt6 cd20425
sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 584-695 1.44e-04

sixth Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the sixth one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410496  Cd Length: 115  Bit Score: 43.21  E-value: 1.44e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  584 VEVKVSHIENPGSFWCQLMR------------NAQGFRTLMCDiedyckssEPSPYEGDTrVClAKRTASGRWSRALISG 651
Cdd:cd20425      2 TEVYVSHVNSPSDFYVQLAQdedelsmiseklNASKANDEEVE--------CESLQLGDL-IC-AEYPEDGLWYRAVVKE 71

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1276740342  652 AHSLEHVRVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSL 695
Cdd:cd20425     72 KIPNNLVSVQFIDYGNTSVVQPSKIHRLPKELLSIPALSIHCFL 115
Tudor_TDRD1_rpt3 cd20410
third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 311-365 1.55e-04

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410481 [Multi-domain]  Cd Length: 59  Bit Score: 41.17  E-value: 1.55e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1276740342  311 KPGSPCasCGL---DGQWYRALLLETFRPQrCAQVLHVDYGRKELVSCSSLRYLLPEY 365
Cdd:cd20410      4 IVGEPC--CAFfsgDGNWYRAMVKEILPGG-AVKVHFVDYGNVEEVTLDKLRKITSTF 58
Tudor_vreteno-like_rpt1 cd20444
first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; ...
 1378-1434 1.82e-04

first Tudor domain found in Drosophila melanogaster protein vreteno and similar proteins; Vreteno is a gonad-specific protein essential for germline development to repress transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process in both germline and somatic gonadal tissues by mediating the repression of transposable elements during meiosis. Vreteno contains two Tudor domains. The model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410515  Cd Length: 55  Bit Score: 41.14  E-value: 1.82e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1276740342 1378 PQIGDPCIVRYreDGHYYRALITNICDGELA-SVRLVDFGNAEdCVDAKELWSIPSEL 1434
Cdd:cd20444      1 PTPGQMVIAKF--DGNHYRAIVLRVLNPDLKiLVRFVDFGNVE-VMKLENLYECPEYL 55
Tudor_TDRD15_rpt7 cd20442
seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 576-693 2.55e-04

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410513  Cd Length: 160  Bit Score: 43.49  E-value: 2.55e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  576 GELEVGSTVEVkvshIENpGSFWCQLMRNAQGFRTLMCDIEDYCKSSEPSPYEGDTR--VCLAKRTASGRWSRALISGAH 653
Cdd:cd20442      1 GQIEKGTLLSV----SKN-GTFYVRLLRNSEQLTDLESLIAKEAKKCKFVPVEDIKEglECLAKSKKNLKWYRAVVEHLY 75

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|.
gi 1276740342  654 SL-EHVRVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRC 693
Cdd:cd20442     76 PEtEKMLVFFVDHGITEVVSMGNIKQLSNDLLQIPRQAVLC 116
Tudor_TDRD1_rpt2 cd20409
second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 1377-1435 2.79e-04

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410480  Cd Length: 82  Bit Score: 41.29  E-value: 2.79e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1276740342 1377 CPQIGDPCIVRYREDGHYYRALITNICDGELASVRLVDFGNAEDcVDAKELWSIPSELL 1435
Cdd:cd20409     25 SPAVGEVCCAQFTEDNQWYRASVLAYSSEDSVLVGYIDFGNSEE-VALSRLRPIPPSLL 82
Tudor_TDRD5 cd20419
Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is ...
 1334-1446 3.35e-04

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410490  Cd Length: 118  Bit Score: 42.05  E-value: 3.35e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1334 YATVIDGPEYFWCQFA---DSEKLQYLETEVQS--AGKQLSDR-RSCTQCPQIGDPCIVRYREDGHYYRALITNICDGEL 1407
Cdd:cd20419      1 FVEYIESPSQFYVRFYskdTSEMLEDMMIEMRRcySNEHVSERyVMPEAFIQPGQVCCVRIPEDVWWYRVIIHQVLNKQE 80

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1276740342 1408 ASVRLVDFGNAEdCVDAKELWSIPSELLLVPMQAFPCCL 1446
Cdd:cd20419     81 VEVFYPDFGDIG-TVQKSRLRFLKCCYSKLPAQAIPASL 118
Tudor_TDRD15_rpt7 cd20442
seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 812-918 3.72e-04

seventh Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the seventh one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410513  Cd Length: 160  Bit Score: 43.10  E-value: 3.72e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  812 TFYCQLARNTNVLEQLSYNIMQLSKALLNLKASTLAPGTLCLARYTDGN-WYRGIIIEKEPSK----VFFVDFGNTyiAV 886
Cdd:cd20442     16 TFYVRLLRNSEQLTDLESLIAKEAKKCKFVPVEDIKEGLECLAKSKKNLkWYRAVVEHLYPETekmlVFFVDHGIT--EV 93

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1276740342  887 DHLLPIPRDAHDVLLLPMQALKCSLSDIPHHI 918
Cdd:cd20442     94 VSMGNIKQLSNDLLQIPRQAVLCRWNWPESSK 125
Tudor_TDRD3 cd20413
Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is ...
 1166-1205 3.92e-04

Tudor domain found in Tudor domain-containing protein 3 (TDRD3) and similar proteins; TDRD3 is a scaffolding protein that specifically recognizes and binds dimethylarginine-containing proteins. In the nucleus, it acts as a coactivator; it recognizes and binds asymmetric dimethylation on the core histone tails associated with transcriptional activation (H3R17me2a and H4R3me2a) and recruits proteins at these arginine-methylated loci. In the cytoplasm, it may play a role in the assembly and/or disassembly of mRNA stress granules and in the regulation of translation of target mRNAs by binding Arg/Gly-rich motifs (GAR) in dimethylarginine-containing proteins. TDRD3 contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410484  Cd Length: 53  Bit Score: 40.02  E-value: 3.92e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1276740342 1166 WQSGDVICAVFPEDNLWYRALVMEQQPNGLLS-VQFIDYGN 1205
Cdd:cd20413      1 WKPGDECLAKYWEDNKFYRAEVTAVHPSGKTAvVKFMEYGN 41
TUDOR pfam00567
Tudor domain;
69-133 3.93e-04

Tudor domain;


Pssm-ID: 425754 [Multi-domain]  Cd Length: 117  Bit Score: 41.96  E-value: 3.93e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1276740342   69 PGELCLVQVGLMWHRCRV-VSRQAQDSRVFLLDEGRTITAGAGSLAPGRSEFFHLPSEVLGCVLAG 133
Cdd:pfam00567   52 DGCVAAFSEDGKWYRAKItESLDDGLVEVLFIDYGNTETVPLSDLRPLPPELESLPPQAIKCQLAG 117
TUDOR smart00333
Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in ...
 311-364 4.69e-04

Tudor domain; Domain of unknown function present in several RNA-binding proteins. 10 copies in the Drosophila Tudor protein. Initial proposal that the survival motor neuron gene product contain a Tudor domain are corroborated by more recent database search techniques such as PSI-BLAST (unpublished).


Pssm-ID: 197660  Cd Length: 57  Bit Score: 39.95  E-value: 4.69e-04
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1276740342   311 KPGSPCASCGLDGQWYRALLLETFRPQRCaQVLHVDYGRKELVSCSSLRyLLPE 364
Cdd:smart00333    4 KVGDKVAARWEDGEWYRARIVKVDGEQLY-EVFFIDYGNEEVVPPSDLR-QLPE 55
Tudor_TDRD1_rpt2 cd20409
second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 825-893 1.30e-03

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410480  Cd Length: 82  Bit Score: 39.36  E-value: 1.30e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1276740342  825 EQLSYNIMQLSKALLNLKASTL---APGTLCLARYTDGN-WYRGIIIEKEPSK---VFFVDFGNT-YIAVDHLLPIP 893
Cdd:cd20409      2 RQLAELQESLSAYCKVAPASSDfspAVGEVCCAQFTEDNqWYRASVLAYSSEDsvlVGYIDFGNSeEVALSRLRPIP 78
Tudor_SPF30 cd20399
Tudor domain found in survival of motor neuron-related-splicing factor 30 (SPF30) and similar ...
 1166-1212 1.30e-03

Tudor domain found in survival of motor neuron-related-splicing factor 30 (SPF30) and similar proteins; SPF30, also called 30 kDa splicing factor SMNrp, SMN-related protein, or survival motor neuron domain-containing protein 1 (SMNDC1), is an essential pre-mRNA splicing factor required for assembly of the U4/U5/U6 tri-small nuclear ribonucleoprotein into the spliceosome. Overexpression of SPF30 causes apoptosis. It contains one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410470 [Multi-domain]  Cd Length: 55  Bit Score: 38.44  E-value: 1.30e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1276740342 1166 WQSGDVICAVFPEDNLWYRALVMEQQPNGLLSVQFIDYGNMSVVHTN 1212
Cdd:cd20399      1 WKVGDKCMAVWSEDGQYYEATIEEISEDGTCTVTFDGYGNTEVTPLS 47
Tudor_TDRD6_rpt2 cd20421
second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; ...
 1121-1235 1.34e-03

second Tudor domain found in Tudor domain-containing protein 6 (TDRD6) and similar proteins; TDRD6, also called antigen NY-CO-45 or cancer/testis antigen 41.2 (CT41.2), is a testis-specific expressed protein that was localized to the chromatoid bodies in germ cells, and is involved in spermiogenesis, chromatoid body formation, and for proper precursor and mature miRNA expression. Mutations in TDRD6 may be associated with human male infertility and early embryonic lethality. TDRD6 contains seven Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410492  Cd Length: 130  Bit Score: 40.87  E-value: 1.34e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342 1121 SVYVSHINDLSDFYIQLIEDEAEINNLSERLNDV---RTRPQYHTGPQwQSGDViCAVFPEDNLWYRALVMEQ-QPNGLL 1196
Cdd:cd20421     14 TVVVTEVTDPHRIFCQLRSLSQELKRLSESMHQYyegRVGSGYETRPE-KLGSP-CAARGSDGRWYRAVLQQVfSANRVV 91

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1276740342 1197 SVQFIDYGNMSVVHTNRTGRLGPVDAVLPALCLHCSLWG 1235
Cdd:cd20421     92 EVLHVDYGRKEVVSVSNLRYLAPEYFRMPVVTYPCALFG 130
Tudor_TDRD12_rpt1 cd20434
first Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; ...
 586-702 1.61e-03

first Tudor domain found in Tudor domain-containing protein 12 (TDRD12) and similar proteins; TDRD12, also called ES cell-associated transcript 8 protein (ECAT8), is a putative ATP-dependent DEAD-like RNA helicase that is essential for germ cell development and maintenance. It acts as a unique piRNA biogenesis factor essential for secondary PIWI interacting RNA (piRNA) biogenesis. TDRD12 contains two Tudor domains, one at the N-terminus and the other at the C-terminal end. The model corresponds to the first/N-terminal one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410505  Cd Length: 164  Bit Score: 41.25  E-value: 1.61e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  586 VKVSHIENPGSFWC-------QLMRNAQGFRTLMCDIED----YCKSSE---PSPYEgDTRVCLAKRTASGRWSRALI-S 650
Cdd:cd20434      1 IQVLKIEDPGCFWGrilkgsgDLVVNPEEYENLQDEMNQfyhkGYKDVEeikPSTLE-EGQVCVVFCEELKCWCRAVVeS 79

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1276740342  651 GAHSLEHVRV--VFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSLYNlIQPM 702
Cdd:cd20434     80 LMSSADDYLAecFLVDYAKYIPVKSKDIRVALEAFMKLPYRAKKFRLYG-IKPV 132
Tudor_dTUD-like cd20379
Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar ...
 69-106 1.92e-03

Tudor domain found in Drosophila melanogaster maternal protein Tudor (dTUD) and similar proteins; dTUD is required during oogenesis for the formation of primordial germ cells and for normal abdominal segmentation. It contains 11 Tudor domains. The family also includes mitochondrial A-kinase anchor protein 1 (AKAP1) and Tudor domain-containing proteins (TDRDs). AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), or dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), or protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. TDRDs have diverse biological functions and may contain one or more copies of the Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410450  Cd Length: 50  Bit Score: 37.88  E-value: 1.92e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1276740342   69 PGELCLVQVGL--MWHRCRVVSRQAQDS-RVFLLDEGRTIT 106
Cdd:cd20379      1 VGDLCAAKYEEdgKWYRARVLEVLSNDKvEVFFVDYGNTET 41
Tudor_TDRD2 cd20412
Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, ...
 610-694 3.17e-03

Tudor domain found in Tudor domain-containing protein 2 (TDRD2) and similar proteins; TDRD2, also called Tudor and KH domain-containing protein (TDRKH), participates in the primary piwi-interacting RNA (piRNA) biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. The family also includes the TDRD2 homolog found in Drosophila melanogaster (dTDRKH), which is also called partner of PIWIs protein, or PAPI, and is involved in Zucchini-mediated piRNA 3'-end maturation. TDRD2 contains two KH domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410483  Cd Length: 95  Bit Score: 38.82  E-value: 3.17e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  610 TLMCDIEDYCKSSEPSPyeGDTRVCLAKRTAS-----GRWSRALISGAHSLEHVRVVFVDYGDRDVVSTKDILSVSDVFF 684
Cdd:cd20412      8 KLVQEMTQYYESEENRH--TLLTVQVGDIVAApfrhdGSWYRARVLGFLENGNLDLYFVDYGDSGYVPLEDLRALRSDFL 85

                           90
                   ....*....|
gi 1276740342  685 QVRAQAFRCS 694
Cdd:cd20412     86 SLPFQAIECS 95
Tudor_TDRD5 cd20419
Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is ...
 588-695 4.13e-03

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410490  Cd Length: 118  Bit Score: 38.97  E-value: 4.13e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  588 VSHIENPGSFWCQLMRN--AQGFRTLMCDIEDyCKSSE--------PSPYEGDTRVCLAKRTASGRWSRALISGAHSLEH 657
Cdd:cd20419      2 VEYIESPSQFYVRFYSKdtSEMLEDMMIEMRR-CYSNEhvseryvmPEAFIQPGQVCCVRIPEDVWWYRVIIHQVLNKQE 80

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1276740342  658 VRVVFVDYGDRDVVSTKDILSVSDVFFQVRAQAFRCSL 695
Cdd:cd20419     81 VEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118
Tudor_TDRD1_rpt2 cd20409
second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 311-364 4.33e-03

second Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the second one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410480  Cd Length: 82  Bit Score: 37.82  E-value: 4.33e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*..
gi 1276740342  311 KPGSPCasCGL---DGQWYRALLLeTFRPQRCAQVLHVDYGRKELVSCSSLRYLLPE 364
Cdd:cd20409     27 AVGEVC--CAQfteDNQWYRASVL-AYSSEDSVLVGYIDFGNSEEVALSRLRPIPPS 80
Tudor_TDRD15_rpt3 cd20438
third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 316-377 4.48e-03

third Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410509  Cd Length: 141  Bit Score: 39.38  E-value: 4.48e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1276740342  316 CASCGLDGQWYRALLLETFRPQrcAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCAL 377
Cdd:cd20438     62 CARYSKDRHYYRAVITEVLDLK--VSVYFLDFGNTDTVPFYDVKTLLPEFSELPALAMCCSL 121
Tudor_TDRD15_rpt1 cd20436
first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; ...
 810-914 4.80e-03

first Tudor domain found in Tudor domain-containing protein 15 (TDRD15) and similar proteins; TDRD15 is an uncharacterized Tudor domain-containing protein that contains seven Tudor domains. This model corresponds to the first one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410507  Cd Length: 147  Bit Score: 39.33  E-value: 4.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342  810 PWTFYCQLARNTNVLEQLSYNIMQLSKALLNLKASTLAPGTLCLARYT-DGNWYRGIIIEKEPSK--VFFVDFGNTYIAv 886
Cdd:cd20436     11 PKEVLVKFQGQYNSICELDYHILQNEIQNATKSKSSWGVGEFCLVEDTtSGEWYRGRVLEKIDEKyeVFLIDRGEVLNV- 89

                           90       100
                   ....*....|....*....|....*...
gi 1276740342  887 dHLLPIPRDAHDVLLLPMQALKCSLSDI 914
Cdd:cd20436     90 -HATNMASASGELFQLPPKAVCGIFANI 116
Tudor_TDRD1_rpt3 cd20410
third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; ...
 632-683 5.98e-03

third Tudor domain found in Tudor domain-containing protein 1 (TDRD1) and similar proteins; TDRD1, also called cancer/testis antigen 41.1 (CT41.1), plays a central role during spermatogenesis by participating in the repression transposable elements and preventing their mobilization, which is essential for germline integrity. It acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins, and governs the methylation and subsequent repression of transposons. TDRD1 contains four Tudor domains. This model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410481 [Multi-domain]  Cd Length: 59  Bit Score: 36.94  E-value: 5.98e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1276740342  632 RVCLAKRTASGRWSRALISGAHSLEHVRVVFVDYGDRDVVSTKDILSVSDVF 683
Cdd:cd20410      7 EPCCAFFSGDGNWYRAMVKEILPGGAVKVHFVDYGNVEEVTLDKLRKITSTF 58
Tudor_AKAP1 cd20407
Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; ...
 848-914 6.01e-03

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410478  Cd Length: 76  Bit Score: 37.19  E-value: 6.01e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1276740342  848 PGTLCLArYTDGNWYRGIIIE--KEPSKVF--FVDFGNTY-IAVDHLLPIpRdaHDVLLLPMQALKCSLSDI 914
Cdd:cd20407      7 VGVICAA-PVMNAWYRAQVVGvfEETDEVEikYLDYGGYErVPVDDLRQI-R--SDFMTLPFQATECYLANI 74
Tudor_TDRD5 cd20419
Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is ...
 316-377 7.44e-03

Tudor domain found in Tudor domain-containing protein 5 (TDRD5) and similar proteins; TDRD5 is an RNA-binding protein directly associated with piRNA precursors. It is required for retrotransposon silencing, chromatoid body assembly, and spermiogenesis. TDRD5 participates in the repression of transposable elements and prevents their mobilization, which is essential for germline integrity. TDRD5 contains three LOTUS domains and one Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410490  Cd Length: 118  Bit Score: 38.20  E-value: 7.44e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1276740342  316 CASCGLDGQWYRALLLETFRPQRcAQVLHVDYGRKELVSCSSLRYLLPEYFRMPVVTYPCAL 377
Cdd:cd20419     58 CVRIPEDVWWYRVIIHQVLNKQE-VEVFYPDFGDIGTVQKSRLRFLKCCYSKLPAQAIPASL 118
Tudor_AKAP1 cd20407
Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; ...
 69-136 7.45e-03

Tudor domain found in mitochondrial A-kinase anchor protein 1 (AKAP1) and similar proteins; AKAP1, also called A-kinase anchor protein 149 kDa (AKAP 149), dual specificity A-kinase-anchoring protein 1 (D-AKAP-1), protein kinase A-anchoring protein 1 (PRKA1), or Spermatid A-kinase anchor protein 84 (S-AKAP84), is found in mitochondria and in the endoplasmic reticulum-nuclear envelope, where it anchors protein kinases, phosphatases, and a phosphodiesterase. It regulates multiple cellular processes governing mitochondrial homeostasis and cell viability. AKAP1 binds to type I and II regulatory subunits of protein kinase A and anchors them to the cytoplasmic face of the mitochondrial outer membrane. It contains a C-terminal Tudor domain. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410478  Cd Length: 76  Bit Score: 37.19  E-value: 7.45e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740342   69 PGELCLVQVGLMWHRCRVVSRQAQDSRVF--LLDEGRTITAGAGSLAPGRSEFFHLPSEVLGCVLAGLVP 136
Cdd:cd20407      7 VGVICAAPVMNAWYRAQVVGVFEETDEVEikYLDYGGYERVPVDDLRQIRSDFMTLPFQATECYLANIEP 76
Tudor_TDRD7_rpt3 cd20429
third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; ...
 321-369 9.35e-03

third Tudor domain found in Tudor domain-containing protein 7 (TDRD7) and similar proteins; TDRD7, also called PCTAIRE2-binding protein, or Tudor repeat associator with PCTAIRE-2 (Trap), is a component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. It is required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. It is also essential for dynamic ribonucleoprotein (RNP) remodeling of chromatoid bodies during spermatogenesis. TDRD7 contains three Tudor domains. The model corresponds to the third one. The Tudor domain binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions.


Pssm-ID: 410500  Cd Length: 91  Bit Score: 37.47  E-value: 9.35e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1276740342  321 LDGQWYRALLLETFRpQRCAQVLHVDYGRKELVSCSSLRYLLPEYFRMP 369
Cdd:cd20429     40 IENNWYRVLVKGILT-NGLVSVYELDYGKHELVSIRKVQPLIEKFRQLP 87
Tudor_SF cd04508
Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally ...
 849-879 9.97e-03

Tudor domain superfamily; The Tudor domain is a conserved structural domain, originally identified in the Tudor protein of Drosophila, that adopts a beta-barrel-like core structure containing four short beta-strands followed by an alpha-helical region. It binds to proteins with dimethylated arginine or lysine residues, and may also bind methylated histone tails to facilitate protein-protein interactions. Tudor domain-containing proteins may mediate protein-protein interactions required for various DNA-templated biological processes, such as RNA metabolism, as well as histone modification and the DNA damage response. Members of this superfamily contain one or more copies of the Tudor domain.


Pssm-ID: 410449 [Multi-domain]  Cd Length: 47  Bit Score: 36.02  E-value: 9.97e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1276740342  849 GTLCLARYT-DGNWYRGIIIEKEPSKVFFVDF 879
Cdd:cd04508      1 GDRVEAKWSdDGQWYPATVVAVNDDGKYTVLF 32
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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