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Conserved domains on  [gi|1276740344|ref|NP_001344917|]
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uncharacterized protein LOC626854 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0003700|GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217
PubMed:  22803940|8183940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-53 4.14e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 83.67  E-value: 4.14e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1276740344  13 VTYNDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLTAIG 53
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
157-562 9.16e-13

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.88  E-value: 9.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 157 KPYECNQCGKTFAGHSNLQIHKRTHTGEKPYECKQCGKAFACHST--LRNHKRTHTGEKPYEC-IQCGKTFAQFGHLQCH 233
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 234 EITHNAEKPYECKQCGKAYTRHSNLQRHKRTHTgeKLYECKQCGKAFTCHKYLQIHERSHTGEKPYECKQCGKaftcHST 313
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS--NLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSS----NLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 314 LQVHKRTHTGEKPYQCNQCDKAFACHRYLQIHRRTHTGEKPYECNQCGKAFACHSTLRKHKITHTGEKPYECNQCGKAFA 393
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 394 QFAHLQCHEITHTEE-------KPYECKQCGKAFAGHSYLQIHKRT--HSGE--KPYEC--NQCGKAFEGHSTLRNHKRI 460
Cdd:COG5048   266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 461 HTGEKPYEC--NQCGKTFTQ---VCNLQCHQ--RIHTGEKPYEC--KQCGKAFACHSYLQIHKRTHTGEKPYECK--QCG 529
Cdd:COG5048   346 HTSISPAKEklLNSSSKFSPllnNEPPQSLQqyKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425

                         410       420       430
                  ....*....|....*....|....*....|...
gi 1276740344 530 KAFAFHSTLQVHKRTHTGEKPYECNQCGKAFVC 562
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
COG5048 super family cl34881
FOG: Zn-finger [General function prediction only];
535-615 1.19e-03

FOG: Zn-finger [General function prediction only];


The actual alignment was detected with superfamily member COG5048:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 535 HSTLQVHKRTHTGE----KPYECNQCGKAFVCHSYLQIHKRTHTGEKPCVCKQCGKAFACHST--LRNHKRTHTGEKPYE 608
Cdd:COG5048    14 SVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDL 93


                  ....*..
gi 1276740344 609 CNQCGKT 615
Cdd:COG5048    94 NSKSLPL 100
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-53 4.14e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 83.67  E-value: 4.14e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1276740344  13 VTYNDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLTAIG 53
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
13-54 5.17e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 81.10  E-value: 5.17e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1276740344   13 VTYNDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLTAIGY 54
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-50 5.24e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.89  E-value: 5.24e-17
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1276740344  13 VTYNDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLT 50
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
157-562 9.16e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.88  E-value: 9.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 157 KPYECNQCGKTFAGHSNLQIHKRTHTGEKPYECKQCGKAFACHST--LRNHKRTHTGEKPYEC-IQCGKTFAQFGHLQCH 233
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 234 EITHNAEKPYECKQCGKAYTRHSNLQRHKRTHTgeKLYECKQCGKAFTCHKYLQIHERSHTGEKPYECKQCGKaftcHST 313
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS--NLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSS----NLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 314 LQVHKRTHTGEKPYQCNQCDKAFACHRYLQIHRRTHTGEKPYECNQCGKAFACHSTLRKHKITHTGEKPYECNQCGKAFA 393
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 394 QFAHLQCHEITHTEE-------KPYECKQCGKAFAGHSYLQIHKRT--HSGE--KPYEC--NQCGKAFEGHSTLRNHKRI 460
Cdd:COG5048   266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 461 HTGEKPYEC--NQCGKTFTQ---VCNLQCHQ--RIHTGEKPYEC--KQCGKAFACHSYLQIHKRTHTGEKPYECK--QCG 529
Cdd:COG5048   346 HTSISPAKEklLNSSSKFSPllnNEPPQSLQqyKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425

                         410       420       430
                  ....*....|....*....|....*....|...
gi 1276740344 530 KAFAFHSTLQVHKRTHTGEKPYECNQCGKAFVC 562
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
zf-H2C2_2 pfam13465
Zinc-finger double domain;
173-198 5.57e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.57e-04
                          10        20
                  ....*....|....*....|....*.
gi 1276740344 173 NLQIHKRTHTGEKPYECKQCGKAFAC 198
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
535-615 1.19e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 535 HSTLQVHKRTHTGE----KPYECNQCGKAFVCHSYLQIHKRTHTGEKPCVCKQCGKAFACHST--LRNHKRTHTGEKPYE 608
Cdd:COG5048    14 SVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDL 93


                  ....*..
gi 1276740344 609 CNQCGKT 615
Cdd:COG5048    94 NSKSLPL 100
zf-H2C2_2 pfam13465
Zinc-finger double domain;
594-618 1.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.30e-03
                          10        20
                  ....*....|....*....|....*
gi 1276740344 594 LRNHKRTHTGEKPYECNQCGKTFAR 618
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 13-53 4.14e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 83.67  E-value: 4.14e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1276740344  13 VTYNDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLTAIG 53
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
13-54 5.17e-19

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 81.10  E-value: 5.17e-19
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1276740344   13 VTYNDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLTAIGY 54
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 13-50 5.24e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 74.89  E-value: 5.24e-17
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1276740344  13 VTYNDVLVSFTQEEWALLDPSQKSLYKDVMLETYRNLT 50
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
157-562 9.16e-13

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 70.88  E-value: 9.16e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 157 KPYECNQCGKTFAGHSNLQIHKRTHTGEKPYECKQCGKAFACHST--LRNHKRTHTGEKPYEC-IQCGKTFAQFGHLQCH 233
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 234 EITHNAEKPYECKQCGKAYTRHSNLQRHKRTHTgeKLYECKQCGKAFTCHKYLQIHERSHTGEKPYECKQCGKaftcHST 313
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSIS--NLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSS----NLS 185

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 314 LQVHKRTHTGEKPYQCNQCDKAFACHRYLQIHRRTHTGEKPYECNQCGKAFACHSTLRKHKITHTGEKPYECNQCGKAFA 393
Cdd:COG5048   186 LLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSL 265

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 394 QFAHLQCHEITHTEE-------KPYECKQCGKAFAGHSYLQIHKRT--HSGE--KPYEC--NQCGKAFEGHSTLRNHKRI 460
Cdd:COG5048   266 PTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILL 345

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 461 HTGEKPYEC--NQCGKTFTQ---VCNLQCHQ--RIHTGEKPYEC--KQCGKAFACHSYLQIHKRTHTGEKPYECK--QCG 529
Cdd:COG5048   346 HTSISPAKEklLNSSSKFSPllnNEPPQSLQqyKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCS 425

                         410       420       430
                  ....*....|....*....|....*....|...
gi 1276740344 530 KAFAFHSTLQVHKRTHTGEKPYECNQCGKAFVC 562
Cdd:COG5048   426 KSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
238-634 1.88e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 63.56  E-value: 1.88e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 238 NAEKPYECKQCGKAYTRHSNLQRHKRTHTGEKLYECKQCGKAFTCHKY--LQIHERSHTGEKPYECKQCG---KAFTCHS 312
Cdd:COG5048    29 NAPRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSLplsNSKASSS 108

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 313 TLqvHKRTHTGEKPYQCNQCDKAFACHRYLQIHRRTHTGEKPYECNQCGKAFACHSTLRKHKITHTGEkpyecNQCGKAF 392
Cdd:COG5048   109 SL--SSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAN-----SLSKDPS 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 393 AQFAHLQCHEITHTEEKPYECKQCGKAFAGHSYLQIHKRTHSgEKPYECNQCGKAFEGHSTLRNHKRIHTGEKPYECNQC 472
Cdd:COG5048   182 SNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENS-SSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASES 260

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 473 GKTFTQVCNLQCHQRIHTGE-------KPYECKQCGKAFACHSYLQIHKRT--HTGE--KPYEC--KQCGKAFAFHSTLQ 539
Cdd:COG5048   261 PRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALK 340

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 540 VHKRTHTGEKPYEC--NQCGKAFV------CHSYLQIHKRTHTGEKP-CVCKQCGKAFACHSTLRNHKRTHTGEKPYECN 610
Cdd:COG5048   341 RHILLHTSISPAKEklLNSSSKFSpllnnePPQSLQQYKDLKNDKKSeTLSNSCIRNFKRDSNLSLHIITHLSFRPYNCK 420

                         410       420
                  ....*....|....*....|....*.
gi 1276740344 611 --QCGKTFARHSQLQTHKRIHIEEKP 634
Cdd:COG5048   421 npPCSKSFNRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
213-618 2.06e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 2.06e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 213 KPYECIQCGKTFAQFGHLQCHEITHNAEKPYEC--KQCGKAYTRHSNLQRHKRTHTGEKLYEC-KQCGKAFTCHKYLQIH 289
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNsKSLPLSNSKASSSSLS 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 290 ERSHTGEKPYECKQCGKAFTchstlQVHKRTHTGEKPYQcNQCDKAFACHRYlqIHRRTHTGEKPYECNQ---CGKAFAC 366
Cdd:COG5048   112 SSSSNSNDNNLLSSHSLPPS-----SRDPQLPDLLSISN-LRNNPLPGNNSS--SVNTPQSNSLHPPLPAnslSKDPSSN 183

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 367 HSTLRKHKITHTGEKPYECNQCGKAFAQFAHLQCHEITHTEEkPYECKQCGKAFAGHSYLQIHKRTHSGEKPYECNQCGK 446
Cdd:COG5048   184 LSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSS-SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPR 262

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 447 AFEGHSTLRNHKRIHTGE-------KPYECNQCGKTFTQVCNLQCHQR--IHTGE--KPYEC--KQCGKAFACHSYLQIH 513
Cdd:COG5048   263 SSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRH 342

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 514 KRTHTGEKPYECKQC-------GKAFAFHSTLQVHKRTHTGEKPYEC--NQCGKAFVCHSYLQIHKRTHTGEKPCVCK-- 582
Cdd:COG5048   343 ILLHTSISPAKEKLLnssskfsPLLNNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnp 422

                         410       420       430
                  ....*....|....*....|....*....|....*.
gi 1276740344 583 QCGKAFACHSTLRNHKRTHTGEKPYECNQCGKTFAR 618
Cdd:COG5048   423 PCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
132-394 2.57e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.46  E-value: 2.57e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 132 DGNQCGKTFSCHTHFEIRKGTYTGEKPYECNQCGKTFAGHSNLQIHKRTHTGEKPYECKQCGKAFACHSTLRNHKRTHTG 211
Cdd:COG5048   172 PANSLSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSS 251

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 212 EKPYECIQCGKTFAQFGHLQCHEITHNAE-------KPYECKQCGKAYTRHSNLQRHKRT--HTGEKLYECKQ----CGK 278
Cdd:COG5048   252 DSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFSCpyslCGK 331

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 279 AFTCHKYLQIHERSHTGEKPYECK--QCGKAFT-----CHSTLQVHKRTHTGEKPYQC--NQCDKAFACHRYLQIHRRTH 349
Cdd:COG5048   332 LFSRNDALKRHILLHTSISPAKEKllNSSSKFSpllnnEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITH 411

                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1276740344 350 TGEKPYECN--QCGKAFACHSTLRKHKITHTGEKPYECNQCGKAFAQ 394
Cdd:COG5048   412 LSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRD 458
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
158-374 4.07e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 4.07e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 158 PYECNQCGKTFAGHSNLQIHKRTHTGEKPYECKQCGKAFAC--HSTLRNHKRTHTGE-----KPYECIQCGKTFAQFGHL 230
Cdd:COG5048   226 SLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPtaSSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPL 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 231 QCHEITHNAE----KPYEC--KQCGKAYTRHSNLQRHKRTHTGEKLYECK--QCGKAFT------CHKYLQIHERSHTgE 296
Cdd:COG5048   306 TRHLRSVNHSgeslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSpllnnePPQSLQQYKDLKN-D 384

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 297 KPYEC--KQCGKAFTCHSTLQVHKRTHTGEKPYQCN--QCDKAFACHRYLQIHRRTHTGEKPYECNQCGKAFACHSTLRK 372
Cdd:COG5048   385 KKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNH 464


                  ..
gi 1276740344 373 HK 374
Cdd:COG5048   465 GK 466
zf-H2C2_2 pfam13465
Zinc-finger double domain;
173-198 5.57e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 5.57e-04
                          10        20
                  ....*....|....*....|....*.
gi 1276740344 173 NLQIHKRTHTGEKPYECKQCGKAFAC 198
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
257-282 9.84e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 9.84e-04
                          10        20
                  ....*....|....*....|....*.
gi 1276740344 257 NLQRHKRTHTGEKLYECKQCGKAFTC 282
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
202-226 1.04e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.04e-03
                          10        20
                  ....*....|....*....|....*
gi 1276740344 202 LRNHKRTHTGEKPYECIQCGKTFAQ 226
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
314-338 1.11e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.11e-03
                          10        20
                  ....*....|....*....|....*
gi 1276740344 314 LQVHKRTHTGEKPYQCNQCDKAFAC 338
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
535-615 1.19e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 41.61  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1276740344 535 HSTLQVHKRTHTGE----KPYECNQCGKAFVCHSYLQIHKRTHTGEKPCVCKQCGKAFACHST--LRNHKRTHTGEKPYE 608
Cdd:COG5048    14 SVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDL 93


                  ....*..
gi 1276740344 609 CNQCGKT 615
Cdd:COG5048    94 NSKSLPL 100
zf-H2C2_2 pfam13465
Zinc-finger double domain;
594-618 1.30e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.30e-03
                          10        20
                  ....*....|....*....|....*
gi 1276740344 594 LRNHKRTHTGEKPYECNQCGKTFAR 618
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
454-478 1.39e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.39e-03
                          10        20
                  ....*....|....*....|....*
gi 1276740344 454 LRNHKRIHTGEKPYECNQCGKTFTQ 478
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
538-562 1.49e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.49e-03
                          10        20
                  ....*....|....*....|....*
gi 1276740344 538 LQVHKRTHTGEKPYECNQCGKAFVC 562
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
509-533 1.92e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.92e-03
                          10        20
                  ....*....|....*....|....*
gi 1276740344 509 YLQIHKRTHTGEKPYECKQCGKAFA 533
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
285-310 1.98e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.98e-03
                          10        20
                  ....*....|....*....|....*.
gi 1276740344 285 YLQIHERSHTGEKPYECKQCGKAFTC 310
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
370-394 2.50e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.50e-03
                          10        20
                  ....*....|....*....|....*
gi 1276740344 370 LRKHKITHTGEKPYECNQCGKAFAQ 394
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
341-366 2.76e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.76e-03
                          10        20
                  ....*....|....*....|....*.
gi 1276740344 341 YLQIHRRTHTGEKPYECNQCGKAFAC 366
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
481-506 4.93e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.93e-03
                          10        20
                  ....*....|....*....|....*.
gi 1276740344 481 NLQCHQRIHTGEKPYECKQCGKAFAC 506
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 211-266 5.80e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 5.80e-03
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1276740344 211 GEKPYEC--IQCGKTF-AQFG------HLQCHEITHNA------------EKPYECKQCGKAYTRHSNLQRHkRTHT 266
Cdd:COG5189   346 DGKPYKCpvEGCNKKYkNQNGlkyhmlHGHQNQKLHENpspekmnifsakDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
425-449 6.68e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 6.68e-03
                          10        20
                  ....*....|....*....|....*
gi 1276740344 425 YLQIHKRTHSGEKPYECNQCGKAFE 449
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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