|
Name |
Accession |
Description |
Interval |
E-value |
| MFS_SLC18B1 |
cd17385 |
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ... |
1-356 |
3.65e-164 |
|
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340943 [Multi-domain] Cd Length: 390 Bit Score: 465.15 E-value: 3.65e-164
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 1 MIGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLDQLPEGPIFIAMCFLVRIVDAIGFGAAITA 80
Cdd:cd17385 35 IIGLVFGCFALVIFLTSPIFGKYLVKIGAKFMFVAGMFVSGGCTILFGFLDRVPDGTVFIALCFLVRIVEAVGFAAFITA 114
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 81 SSSILAKAFPNNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLNLYILPSYESDPGKQ--SF 158
Cdd:cd17385 115 SFAIIAKEFPNNIATVLGTLETFSGLGLMLGPPLGGFLYQAGGYELPFLVLGCLLLLTVPLNMFILPRYDDDPSPKsgSM 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 159 WKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVmEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtLRKWLLVF 238
Cdd:cd17385 195 LKLLKIPSVLLLCLSIVSGSVSLGFLDPTLSPHL-RQFKLSPGQVGLMFLILAGSYAISAPLWGWLSDKKK-IPKWLMVI 272
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 239 GNLITAGCYMLLGPVPLLHIKSQLWLLVLVLVVNGISAGMSIIPTFPEMLSCAYANGFEDSISTLGLVSGLFGAMWSVGA 318
Cdd:cd17385 273 GSIITGVGFLLLGPAPLLPIKSELWMVIIGLVLLGLSLGAALVPTFPELLNCAREYGFPDNLSTYGLVSGLFNAAFSLGA 352
|
330 340 350
....*....|....*....|....*....|....*...
gi 1302188055 319 FMGPILGGFLCEKIGFEWAAAMQGLWTLLSGVSMALFY 356
Cdd:cd17385 353 FIGPTLGGFLLERLGFEWAATIQAGLAFVVGILMSIYY 390
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
1-356 |
3.46e-46 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 162.36 E-value: 3.46e-46
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 1 MIGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLDQlpegpifIAMCFLVRIVDAIGFGAAITA 80
Cdd:cd17325 32 QIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAFATS-------YWQLLLARFLQGLASAAVWPA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 81 SSSILAKAFP-NNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLNLYILP---------SYE 150
Cdd:cd17325 105 AMALIADIAPpEERGRAMGIFSSAIGLGFLIGPLLGGLLADALGYRAPFLVCAALALLALVLALLLLPeprpppnkrAVS 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 151 SDPGKQSFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPt 230
Cdd:cd17325 185 AARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIG- 263
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 231 lRKWLLVFGNLITAGCYMLLGPVPllhiksQLWLLVLVLVVNGISAGMSIIPTFPEMLSCAYANGfedsistLGLVSGLF 310
Cdd:cd17325 264 -RKPLILIGLLLSAVALLLLPLAT------SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEG-------RGTAMGLF 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*.
gi 1302188055 311 GAMWSVGAFMGPILGGFLCEKIGFEWAAAMQGLWTLLSGVSMALFY 356
Cdd:cd17325 330 NTAFSLGMVLGPLLGGFLYDAFGFATPFLAAAALLLLAAVLFLLLR 375
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
1-318 |
3.41e-20 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 90.80 E-value: 3.41e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 1 MIGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLDQLPegpifiaMCFLVRIVDAIGFGAAITA 80
Cdd:COG2814 46 QAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAPSLW-------LLLAARFLQGLGAGALFPA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 81 SSSILAKAFP-NNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLNLYILPSY---ESDPGKQ 156
Cdd:COG2814 119 ALALIADLVPpERRGRALGLLGAGLGLGPALGPLLGGLLADLFGWRWVFLVNAVLALLALLLLLRLLPESrpaARARLRG 198
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 157 SFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLL 236
Cdd:COG2814 199 SLRELLRRPRLLLLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFG--RRRLL 276
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 237 VFGNLITAGCYMLLGPVPllhiksQLWLLVLVLVVNGISAGMSIIPTFPEMLSCAyangfedSISTLGLVSGLFGAMWSV 316
Cdd:COG2814 277 LIGLLLLALGLLLLALAG------SLWLLLLALFLLGFGFGLLFPLLQALVAELA-------PPEARGRASGLYNSAFFL 343
|
..
gi 1302188055 317 GA 318
Cdd:COG2814 344 GG 345
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
1-355 |
7.77e-19 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 86.85 E-value: 7.77e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 1 MIGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLDQLpegpifiAMCFLVRIVDAIGFGAAITA 80
Cdd:COG2271 46 QLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGFATSF-------WQLLLLRFLLGLGEAGFFPA 118
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 81 SSSILAKAFPNNV-ATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLNLYilpsyesdpgkqsfw 159
Cdd:COG2271 119 ALKLIAEWFPPKErGRALGIFNAGGPLGGALAPPLLGWLLAAFGWRAAFLILGLPGLLLALLRFW--------------- 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 160 klvtlpkmgLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPTLRKWLLVFG 239
Cdd:COG2271 184 ---------LLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIG 254
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 240 NLITAGCYMLLGPVPllhiksQLWLLVLVLVVNGISAGMSIIPTFPEMLSCAyangfedSISTLGLVSGLFGAMWSVGAF 319
Cdd:COG2271 255 LLLAALALLLLALLP------SPALAIALLFLAGFGLGGAFGLLWALAAELF-------PKKARGTASGLVNTFGFLGGA 321
|
330 340 350
....*....|....*....|....*....|....*.
gi 1302188055 320 MGPILGGFLCEKIGFEWAAAMQGLWTLLSGVSMALF 355
Cdd:COG2271 322 LGPLLVGYLLDATGYQAAFLLLAALALLAALLALLL 357
|
|
| MFS_SLC18A1_2_VAT1_2 |
cd17384 |
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ... |
2-336 |
1.44e-18 |
|
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340942 [Multi-domain] Cd Length: 373 Bit Score: 86.09 E-value: 1.44e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 2 IGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAG---MFVSggvTILFGVLDQlpegpifIAMCFLVRIVDAIGFGAAI 78
Cdd:cd17384 33 VGLLFASKALVQLITNPIVGPLTNRIGYSLPMFVGfviMFIS---TLLFAFGES-------YGVLFLARALQGVGSACSS 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 79 TASSSILAKAFPNN------VATVMGSLevfsGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLNLYILP---SY 149
Cdd:cd17384 103 VAGMGMLASLYPDDkergkaMGIALGGL----ALGVLVGPPFGGVMYEFVGKSAPFLILAFLALLDGALQLFILQpsvKS 178
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 150 ESDPGKQSFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMp 229
Cdd:cd17384 179 EESEEGTPWKTLLKDPYILIAAGAICFSNSGIAILEPCLPIWMMETMCPPKWQLGTAFLPDSIGYLIGTNLFGPLAHKI- 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 230 tlRKWLLVFGNLITAGCYMLLgpVPLLHIKSQLWLLVLVLvvnGISAGMSIIPTFPEMLSCAYANGfedsISTLGLVSGL 309
Cdd:cd17384 258 --GRWLCSLLGMLLVGISLIL--IPLAKNIYGLIIPHFGL---GLGIGMVDSSMMPLLAYLVDLRH----SSVYGSVYAI 326
|
330 340
....*....|....*....|....*..
gi 1302188055 310 FGAMWSVGAFMGPILGGFLCEKIGFEW 336
Cdd:cd17384 327 ADVAFCLAFALGPSLGGAIVKSIGFPW 353
|
|
| NarK |
COG2223 |
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism]; |
2-356 |
1.71e-15 |
|
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
Pssm-ID: 441825 [Multi-domain] Cd Length: 392 Bit Score: 77.23 E-value: 1.71e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 2 IGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLDQLPegpIFIAMCFLVRIVDAIGFGAAItas 81
Cdd:COG2223 42 LGLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLALAVSYW---LLLLLGLLLGIGGGGSFAVGI--- 115
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 82 sSILAKAFP-NNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLNLYIL---PSYESDPGKQS 157
Cdd:COG2223 116 -ALVSKWFPpDRRGLALGLAAGGGNLGAAVAAFLAPLLIAAFGWRNAFLILGILLLVVAVLAWLFLrdpPAGAAAAAKAS 194
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 158 F---WKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtLRKW 234
Cdd:COG2223 195 LrdqLEALRDPRFWLLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIG-GRRV 273
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 235 LLVFGNLITAGCymllgpVPLLHIKSQLWLLVLVLVVNGISAGMSIIPTFPEMlscayanGFEDSISTLGLVSGLFGAMW 314
Cdd:COG2223 274 LLIVFALMALGL------LLLALALGSLWLFLVLFLLLGLALGGGNGAVFALV-------PDIFPTKNAGAVYGLVGAAG 340
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1302188055 315 SVGAFMGPILGGFLCEKIG-FEWAAAMQGLWTLLSGVSMALFY 356
Cdd:COG2223 341 GLGGFLGPLLFGALLDATGsYTAAFLVFAVLALVALVLTLLLY 383
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
1-322 |
7.41e-15 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 74.76 E-value: 7.41e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 1 MIGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLDQLPegpifiaMCFLVRIVDAIGFGAAITA 80
Cdd:pfam07690 33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLFASSLW-------LLLVLRVLQGLGAGALFPA 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 81 SSSILAKAFP-NNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLNLYILPSYESDPGKQ--- 156
Cdd:pfam07690 106 ALALIADWFPpEERGRALGLVSAGFGLGAALGPLLGGLLASLFGWRAAFLILAILSLLAAVLLLLPRPPPESKRPKPaee 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 157 ------SFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFvMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPT 230
Cdd:pfam07690 186 arlsliVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLY-QEVLGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGR 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 231 LRKWLLVFGNLITAGCYMLLgpvpLLHIKSQLWLLVLVlvvngISAGMSIIPTFPEMLSCAYANGFEDSIstlGLVSGLF 310
Cdd:pfam07690 265 RRRLLLALLLLILAALGLLL----LSLTLSSLWLLLAL-----LLLGFGFGLVFPALNALVSDLAPKEER---GTASGLY 332
|
330
....*....|..
gi 1302188055 311 GAMWSVGAFMGP 322
Cdd:pfam07690 333 NTAGSLGGALGP 344
|
|
| MFS_YfmO_like |
cd17474 |
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ... |
1-350 |
9.52e-14 |
|
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341027 [Multi-domain] Cd Length: 374 Bit Score: 71.83 E-value: 9.52e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 1 MIGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLDQLPEGPIFiamcflvRIVDAIGFGAAITA 80
Cdd:cd17474 35 QVGLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLSDSFALLLAG-------RALQGIGAAGLGPL 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 81 SSSILAKAFP-NNVATVMGSLEVFSGLGLVAGPPLGGLLyQSFGYEVPFIFLGCIVLLMIPLNLYILPSYESDPGKQSFW 159
Cdd:cd17474 108 ALTLIGDLFEgGERAKAMGLYEAALGLGIAVGPLLGGLL-AAISWRYPFFLLAALIPVAFLAILFLLPEPKEKAKSSSAT 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 160 KLVTLPKM----GLLAFVIISLSSCFGF--LDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSdKMPTLRK 233
Cdd:cd17474 187 KLRDLKKAlrgrGLLTFLVSAFLYFFLYfaFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLL-KKRFGAR 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 234 WLLVFGNLITAGCYMLLGPVPllhiksQLWLLVLVLVVNGISAGMSiIPTFPEMLscayANGFEDSIstLGLVSGLFGAM 313
Cdd:cd17474 266 RILVIGLLLYALSLLLLGFVP------SLALLLIAIVLFGLGLGLN-LPLLTTLV----TELAPEEE--RGTASSLYNFV 332
|
330 340 350
....*....|....*....|....*....|....*..
gi 1302188055 314 WSVGAFMGPILGGFLCEKIGFEWAAAMQGLWTLLSGV 350
Cdd:cd17474 333 RFLGQAVGPLLFGLLLEIFGLSAPFLVGAAIALAAAV 369
|
|
| MFS_YfcJ_like |
cd17489 |
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ... |
1-355 |
6.22e-13 |
|
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341042 [Multi-domain] Cd Length: 367 Bit Score: 69.16 E-value: 6.22e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 1 MIGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLDQlpegpifIAMCFLVRIVDAIGFGAAITA 80
Cdd:cd17489 32 VAGLVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLLATS-------VALLLVLRLIHGIGWGAFTTA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 81 SSSILAKAFPN-NVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLNLYI----LPSYESDPGK 155
Cdd:cd17489 105 AATLVADIIPPsRRGEGIGYYGLATTLAMALGPALGLFLYQHLGFAVLFIVAAVLALLALLLVFLVkdppPVAAEEAEAG 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 156 QSFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSlstGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWL 235
Cdd:cd17489 185 TRAFRRLVEKKVLPPALILFLASIAYGAISTFLPLYAAERGI---SNAGLFFTVYAIALLLSRPFSGKLSDRKG--PKTV 259
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 236 LVFGNLITAGCYMLLGPVPllhiksQLWLLVLVLVVNGISAGMSiiptFPEMLSCAYANGFEDSIstlGLVSGLFGAMWS 315
Cdd:cd17489 260 IIPGLLLLALGLLLLSFAG------SPWMLLLAAVLYGLGFGLL----FPALQALAVDLVPPHRR---GAANGTFFIFFD 326
|
330 340 350 360
....*....|....*....|....*....|....*....|
gi 1302188055 316 VGAFMGPILGGFLCEKIGFEWAAAMQGLWTLLSGVSMALF 355
Cdd:cd17489 327 LGIGLGGLLLGLVAELFGYRAMFLLAAVVVLLALVLYIFL 366
|
|
| MFS_YxlH_like |
cd17490 |
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ... |
1-356 |
1.57e-12 |
|
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341043 [Multi-domain] Cd Length: 371 Bit Score: 68.02 E-value: 1.57e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 1 MIGMIFGCYALFELLASLVFGKYLVHIGAKFMFI-AGMFVSGGVTILFGvldqLPEGPIFIamcFLVRIVDaiGFGAAIT 79
Cdd:cd17490 32 MIGIILGAYGISQMLLRIPLGILSDRIGKRKLFIiIGLLFTVLASLIMI----LFPSPWGL---LIARFLS--GIAAATW 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 80 ASSSILAKAF--PNNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLNLYILPSYESD----P 153
Cdd:cd17490 103 VSFTVLYASYfpPDEAAKAMGLINLVNNLGQLIAFLIGGLIAEHFGMRAPFLLAALAGVLGFILSLFIKEERREKkpvlT 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 154 GKQSFWKLVTLPKM---GLLAFV--IISLSSCFGFLDPTLSLFVMEKFSLstgyvGLVFLGLSLSYAISSPLFGLLSDKM 228
Cdd:cd17490 183 ELKELLSVLKDKKLlffSLLAILqqMITFSTTFGFTPLIAKQLGASSFQL-----GLLSIIYLLPNALASLLSGTLFYKK 257
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 229 PTLRKWLLvFGNLITAGCYMLlgpVPLLhikSQLWLLVLVLVVNGISAGMsiipTFPEMLSCAYANGFEDSISTlglVSG 308
Cdd:cd17490 258 LGERNTII-IGFLLLGAYCFL---IPFA---PNLTLLYLLQALNGFGTGI----LFPLLMSLSIEGVPAEQRST---AMG 323
|
330 340 350 360
....*....|....*....|....*....|....*....|....*...
gi 1302188055 309 LFGAMWSVGAFMGPILGGFLCEKIGFEWAAAMQGLWTLLSGVSMALFY 356
Cdd:cd17490 324 FFQAIYALGMFLGPVLVGIISEAFGLQTGFFVIGVIALLAAILSLAYY 371
|
|
| MFS_SLC46_TetA_like |
cd17330 |
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ... |
1-258 |
2.95e-12 |
|
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340888 [Multi-domain] Cd Length: 349 Bit Score: 67.22 E-value: 2.95e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 1 MIGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLdqlpegpIFIAMCFLVRIVDAIGFGAAITA 80
Cdd:cd17330 35 YVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLS-------RNLWLLFLARFLDGLTGGNVSVA 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 81 SSSILAKAFPNNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIplnLYIlpsyesdpgkqsfwk 160
Cdd:cd17330 108 QAYIADITDEEERAKAFGIISAAFGLGFILGPALGGFLSTPYGYALPFLVAAALALLNL---VLV--------------- 169
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 161 LVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPTLRKwLLVFGN 240
Cdd:cd17330 170 LFFLPPLRRLLLVYFLIALAFAGLESVFSLFLKDRFGFSPSQIGLLLALVGIAGILAQLLLIPRLAKRLGERK-LLRLGL 248
|
250
....*....|....*...
gi 1302188055 241 LITAGCYMLLGPVPLLHI 258
Cdd:cd17330 249 LLAIIGLLLLPFASSVPL 266
|
|
| MFS_YcaD_like |
cd17477 |
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ... |
1-333 |
7.62e-12 |
|
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341030 [Multi-domain] Cd Length: 360 Bit Score: 66.04 E-value: 7.62e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 1 MIGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLDQLPegpifiaMCFLVRIVDAIGFGAAITA 80
Cdd:cd17477 32 LIGLVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTDSPW-------VWFLLRFVMGIGLAGLFVV 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 81 S-SSILAKAFPNNVATVMGSLEVFSGLGLVAGPPLGGLLYQSfGYeVPFIFLGCIVLL-MIPLNLYILPSYESD-PGKQS 157
Cdd:cd17477 105 SeSWLNALATNENRGRVLGLYSTVLGLGFALGPLLLALVGTA-GA-LPFLIAAVLLLLaLVPLLLTRRAAPEIEeAESIS 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 158 FWKLVTLPKMGLLAFVI--ISLSSCFGFldptLSLFVMEKfSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWL 235
Cdd:cd17477 183 LRRLLRIAPLALLGAFVagFLEGAFYSL----LPLYGLRL-GLSVAQAALLLAAFVLGGLLLQWPLGWLADRFD--RRRV 255
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 236 LVFGNLITAGCYMLLGPVPLLHIksQLWLLVLVlvvngisAGMSIIPTFPemLSCAYANGFEDSiSTLGLVSGLFGAMWS 315
Cdd:cd17477 256 LLGCALLGALAALLLPLVPGLPL--ALLVLLFL-------WGGAAGPLYT--LALALAGDRLPG-DELVAANAALLLLYG 323
|
330
....*....|....*...
gi 1302188055 316 VGAFMGPILGGFLCEKIG 333
Cdd:cd17477 324 LGSVIGPLLAGALMDAFG 341
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
1-348 |
8.16e-10 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 59.87 E-value: 8.16e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 1 MIGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLdqlpegPIFIAMcFLVRIVDAIGFGAAITA 80
Cdd:cd17324 35 QAGLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAALA------PSFALL-LLARALAGLAHGGFWAI 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 81 SSSILAKAFP-NNVATVMGSleVFSGL--GLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLNLYILPSYESDPGKQ- 156
Cdd:cd17324 108 AAAYAADLVPpEKRGRAIGL--VFSGLtlGLVLGRPLGGLLGQLLGWRAAFLAIAVLALLAALLLWRLLPSLPPKKPGSl 185
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 157 ----SFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPTLR 232
Cdd:cd17324 186 gllsSLLLLLRNPRLRLAYLITFLLFGGFFALYTYLAPFLTDVPGFSSSAIIGLLLLFGVAGVVGSPLAGRLADRGGRRA 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 233 kwlLVFGNLITAGCYMLLGPVPllhikSQLWLLVLVLVVNGISAGMsiiptfpeMLSCAYANGFEDSISTLGLVSGLFGA 312
Cdd:cd17324 266 ---LLIALLLLAAALLLLTLLG-----PSPLLLLVGLVLWGLGFFA--------AHSALQTRVLRLAPEARGLASSLYLA 329
|
330 340 350
....*....|....*....|....*....|....*.
gi 1302188055 313 MWSVGAFMGPILGGFLCEKIGFEWAAAMQGLWTLLS 348
Cdd:cd17324 330 AYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLA 365
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
30-355 |
2.69e-09 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 58.37 E-value: 2.69e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 30 KFMFIAGMFVSGGVTILFGVLDQLPEGPIFIaMCFLVRIVDAIGFGAAITASSSILAKAFPNNV--ATVMGSLEVFSGLG 107
Cdd:COG2211 81 RPWILIGAIPLALSFVLLFTAPDLSPTGKLI-YALVTYLLLGLAYTLVNIPYSALGAELTPDYEerTRLSSWRFAFAGLG 159
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 108 LVAGPPLGGLLYQSF------GYEVPFIFLGCIVLLMIPLNL-----YILPSYESDPGKQSFWKLVTLPKMGLLAFVIIS 176
Cdd:COG2211 160 GLLASVLPPPLVAAFggdaalGYRLTALIFAVLGLLAFLLTFfgtkeRPVPEEEKVSLKESLKALLKNRPFLLLLLAYLL 239
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 177 LSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVFGNLITAGCYMLLGPVPll 256
Cdd:COG2211 240 FFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFG--KKKAFIIGLLLAALGLLLLFFLG-- 315
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 257 hiKSQLWLLVLVLVVNGISAGMSIIPTFPEMLSCAYANGFEDSISTLGLVSGLFGAMWSVGAFMGPILGGFLCEKIGFEW 336
Cdd:COG2211 316 --PGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLLLALFGYVA 393
|
330 340
....*....|....*....|....
gi 1302188055 337 AA-----AMQGLWTLLSGVSMALF 355
Cdd:COG2211 394 GAaqspsALTGIRLLFFLLPAVLL 417
|
|
| MFS_ExuT_GudP_like |
cd17319 |
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major ... |
1-354 |
4.02e-09 |
|
Hexuronate transporter, Glucarate transporter, and similar transporters of the Major Facilitator Superfamily; This family is composed of predominantly bacterial transporters for hexuronate (ExuT), glucarate (GudP), galactarate (GarP), and galactonate (DgoT). They mediate the uptake of these compounds into the cell. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340877 [Multi-domain] Cd Length: 358 Bit Score: 57.58 E-value: 4.02e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 1 MIGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLDQLpegpifiAMCFLVRIVDAIGFGAAITA 80
Cdd:cd17319 39 QYGLIASAFFLGYALFQVPGGWLLDRFGARKVLAVSMLLWSLFTALTGFATSL-------TSLYVLRFLLGVAEAGFFPG 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 81 SSSILAKAFPNNV-ATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMiplnlyilpsyesdpgkqSFW 159
Cdd:cd17319 112 AIKALAEWFPARErGRATGLFNSGAPLGAAIGPPLSGWLLLLFGWRWAFIIEGLLGLLL------------------AVL 173
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 160 KLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPTL-RKWLLVF 238
Cdd:cd17319 174 WWFYLRQVWGLALGYFGINYALYGLLTWLPTYLKQARGFSLKQVGLLAAIPFLAGAIGMILGGRLSDRLLRGaRRLVIII 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 239 GNLITAGCYMLLGPVpllhikSQLWLLVLVLVVNGISAGMSIIPTFPemLSCAYANGfedsiSTLGLVSGLFGAMWSVGA 318
Cdd:cd17319 254 GLLLAAVGLLLAYLT------TSPVVAVILLSLAGFGIGAASPVFWS--LPADLLPG-----EAAATAGGLINSGGNLGG 320
|
330 340 350
....*....|....*....|....*....|....*..
gi 1302188055 319 FMGPILGGFLCEKIG-FEWAAAMQGLWTLLSGVSMAL 354
Cdd:cd17319 321 FVAPLLIGYLVDATGsYTAAFLFLAAVALLAALLVLL 357
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
1-337 |
1.21e-08 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 56.40 E-value: 1.21e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 1 MIGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLDQLPegpIFIAMCFLVrivdAIGFGAAITA 80
Cdd:COG0738 44 QAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFALAPSYP---LLLLALFLL----GLGLGLLDVA 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 81 SSSILAKAFPNNVATVMGSLEVFSGLGLVAGPPLGGLLYQ---SFGYEVPFIFLGCIVLLMI------PLNLYILPSYES 151
Cdd:COG0738 117 ANPYVAALGPETAASRLNLLHAFFSLGALLGPLLGGLLILlglSLSWHLPYLILAVLLLLLAllflrsKLPEIEEEEEEA 196
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 152 DPGKQSFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtl 231
Cdd:COG0738 197 AGSAASLKSLLKNPRLLLGGLAIFLYVGAEGAIGDWLPLYLKDVLGLSEATAALGLSLFWGGMTIGRFLGGFLLKRFG-- 274
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 232 RKWLLVFGNLITAGCYMLLGPVPllhiksqlWLLVLVLVVNGISAGMSIIptFPEMLSCAYANGFEDSISTLGLVSglfg 311
Cdd:COG0738 275 PVRLLRLSALLAAVGLLLALLAP--------GPWLALIGLALVGLGLSLM--FPTIFSLALDGLGKRTAAAVSAVL---- 340
|
330 340
....*....|....*....|....*.
gi 1302188055 312 AMWSVGAFMGPILGGFLCEKIGFEWA 337
Cdd:COG0738 341 IMGIVGGAIGPPLIGFLADAFGLRAA 366
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
1-356 |
6.04e-08 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 54.16 E-value: 6.04e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 1 MIGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLDQLpegPIFIAMCFLVrivdAIGFGAAITA 80
Cdd:cd17329 36 IVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGFAHSP---WLFAIALVLT----GFGGGLFEPA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 81 SSSILAKAFPNNVATVMGSLEVFSG-LGLVAGPPLGGLLYQsFGYEVPFIFLGC-------IVLLMIPLNLYILPSYESD 152
Cdd:cd17329 109 SEAMIADVTTPENRTRAFSLLYWAInLGVAIGPLLGGLLLL-YSFRLLFLAAAVlfllaalVLLFLLPETRPKRRAAEKT 187
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 153 PGKQSFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtLR 232
Cdd:cd17329 188 EILRGYKIVLRDRAFLLFLLASFLISLIYFQLESTLPVYVVEILGLGESLLGLLLALNALLIVLLQFPVARLVERFR-LR 266
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 233 KWLLVFGNLITAGCYMLLGPVPLLHIksqlwllvlvlvvngisAGMSIIPTFPEMLSCAYANGFEDSIS---TLGLVSGL 309
Cdd:cd17329 267 KILMIGILLFAIGFAVLAFANTLAVL-----------------ILAMIVLTLGEMLVFPAVQTLVAALAppdKRGSYMGF 329
|
330 340 350 360
....*....|....*....|....*....|....*....|....*..
gi 1302188055 310 FGAMWSVGAFMGPILGGFLCEKIGFEWAAAMQGLWTLLSGVSMALFY 356
Cdd:cd17329 330 YALAWGLGRAIGPLVGGLLLDLLGPGLPWLILAALGLIAAALLLGLQ 376
|
|
| MFS |
cd06174 |
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ... |
1-328 |
1.37e-07 |
|
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.
Pssm-ID: 349949 [Multi-domain] Cd Length: 378 Bit Score: 52.81 E-value: 1.37e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 1 MIGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLDQLPegpifiaMCFLVRIVDAIGFGAAITA 80
Cdd:cd06174 32 QLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAFAPSFW-------LLLLGRFLLGLGSGLIDPA 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 81 SSSILAKAFP-NNVATVMGSLEVFSGLGLVAGPPLGGLLYQ--SFGYEVPFIFLGCIVLLMIPLNLYILPSYESDPGKQ- 156
Cdd:cd06174 105 VLALIADLFPeRERGRALGLLQAFGSVGGILGPLLGGILASslGFGWRAVFLIAAALALLAAILLLLVVPDPPESARAKn 184
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 157 ----------SFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSD 226
Cdd:cd06174 185 eeassksvlkLLKRVLKNPGLWLLLLAIFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSD 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 227 KMPTLRKWLLVFGNLITAGC-YMLLGPVPLLHIKSQLWLLVLVLVVNGISAGMSIIPTFPEMlscayangfedsistLGL 305
Cdd:cd06174 265 RLIGRKPLLLIGLLLMALGLaLLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEI---------------RGT 329
|
330 340
....*....|....*....|...
gi 1302188055 306 VSGLFGAMWSVGAFMGPILGGFL 328
Cdd:cd06174 330 AFGLLNTFGFLGGAIGPLLAGFL 352
|
|
| ProP |
COG0477 |
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ... |
1-251 |
1.81e-07 |
|
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];
Pssm-ID: 440245 [Multi-domain] Cd Length: 295 Bit Score: 52.12 E-value: 1.81e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 1 MIGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLDQlpegpifIAMCFLVRIVDAIGFGAAITA 80
Cdd:COG0477 50 QLGWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGLAPS-------PELLIAARALQGIGAGGLMPG 122
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 81 SSSILAKAFPNNV-ATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLNLYILPSYESDPGKQSFW 159
Cdd:COG0477 123 ALALIAELFPARErGRALGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALA 202
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 160 KLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPTLRKWLLVFG 239
Cdd:COG0477 203 LAALLLAALALALLALLLLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALLLLL 282
|
250
....*....|..
gi 1302188055 240 NLITAGCYMLLG 251
Cdd:COG0477 283 LLLLLLLLLALL 294
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
106-350 |
1.84e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 52.55 E-value: 1.84e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 106 LGLVAGPPLGGLL--YQSFGYEVPFIFLGCIVLLMIPLNLYILPSYE--SDPGKQSFWKLVTLPKMGLLAFVIISLSSCF 181
Cdd:cd17370 135 LGAVLGPLLAALLlyLLGGNYRTIFLLAAIPALLALLILLFVVKEYPrpPKLRKKSKKTSLKKLPKAFWLYLLAVALFAL 214
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 182 GFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVFGNLITAGCYMLLGpvpllhIKSQ 261
Cdd:cd17370 215 GNFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIG--RKKLLILGYLSLALAYLGFA------LGSS 286
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 262 LWLLVLVLVVNGISAGMSiiptfpEMLSCAYANGFEDSiSTLGLVSGLFGAMWSVGAFMGPILGGFLCEKIGFEWAAAMQ 341
Cdd:cd17370 287 LWLLLLGFILWGLYMGAQ------ESIERAAVADLVPA-ELRGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFS 359
|
....*....
gi 1302188055 342 GLWTLLSGV 350
Cdd:cd17370 360 AVLALIALL 368
|
|
| MFS_SLC18A3_VAChT |
cd17383 |
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator ... |
2-347 |
2.43e-07 |
|
Vesicular acetylcholine transporter (VAChT) and similar transporters of the Major Facilitator Superfamily; Vesicular acetylcholine transporter (VAChT) is also called solute carrier family 18 member 3 (SLC18A3) in vertebrates and uncoordinated protein 17 (unc-17) in Caenorhabditis elegans. It is a glycoprotein involved in acetylcholine transport into synaptic vesicles and is responsible for the accumulation of acetylcholine into pre-synaptic vesicules of cholinergic neurons. Variants in SLC18A3 are associated with congenital myasthenic syndrome in humans. VAChT belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340941 [Multi-domain] Cd Length: 378 Bit Score: 52.31 E-value: 2.43e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 2 IGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAG---MFVSggvTILFGVLDQLpegpifiAMCFLVRIVDAIGFGAAI 78
Cdd:cd17383 32 IGVLFASKAIVQLLVNPFSGTLIDRVGYDIPMMIGltvMFLS---TAVFAFGESY-------AVLFFARSLQGVGSAFAD 101
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 79 TASSSILAKAFP--NNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLNLYILPSYE------ 150
Cdd:cd17383 102 TAGLAMIADRFTeeAERSKALGIALAFISFGCLVAPPFGGILYEFAGKEVPFLILAFVCLLDGLLLLLVMKPVRretran 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 151 -SDPGKQSFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMP 229
Cdd:cd17383 182 mPEPVGTPIHRLLMDPYIAVCAGALTMANVSLAFLEPTIANWMKDTMNASEWQMGLVWLPAFFPHVLGVYLTVKLAAKYP 261
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 230 TLRKWLLVFGNLITAGCYMLlgpVPLLHIKSQLwllvlVLVVNGISAGM-----SIIPTFPEMLSCAYangfedsISTLG 304
Cdd:cd17383 262 HYQWLMAAVGLAIEGASCFI---VPFCTNFGVL-----IIPLCGICFGIalvdtALLPTLGFLVDVRH-------VSVYG 326
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1302188055 305 LVSGLFGAMWSVGAFMGPILGGFLCEKIGFEWAAAMQGLWTLL 347
Cdd:cd17383 327 SVYAIADISYSLAYALGPIVAGQIVHSIGFTQLNIGIGLANLL 369
|
|
| MFS_MJ1317_like |
cd17370 |
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ... |
1-141 |
8.67e-07 |
|
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340928 [Multi-domain] Cd Length: 371 Bit Score: 50.62 E-value: 8.67e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 1 MIGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLDQLPegPIFIAMCFLvrivdAIGFGAAITA 80
Cdd:cd17370 235 LIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGYLSLALAYLGFALGSSLW--LLLLGFILW-----GLYMGAQESI 307
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1302188055 81 SSSILAKAFPNNV-ATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPL 141
Cdd:cd17370 308 ERAAVADLVPAELrGTAYGLFNTVVGIGWLLASLIAGYLWDLISPSAAFLFSAVLALIALLL 369
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
1-250 |
1.39e-06 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 49.85 E-value: 1.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 1 MIGMIFGCYALFELLASLVFGKYL-VHIGAKFMFIAGMFVSGGVTILFGVLDQLPegPIFIAMCFLvrivdaigFGAAIT 79
Cdd:cd17471 33 QIGIFMTLSALSGIVVSQWLGRLSdRGGDRKPLILLALLAGALGYLLFAFLRNYW--VLLLVGVVL--------LSLGAA 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 80 ASSSILAKAF-------PNNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLNLYILPSYESD 152
Cdd:cd17471 103 AFPQLFALAReyadrssGRDATLFNSVLRAAFSLAWVIGPPLAFLLLDVLGFTGLFLLAALLYLVVALLVLFLLPSVKPP 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 153 PGK----QSFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFlglSLSYAISSP---LFGLLS 225
Cdd:cd17471 183 AQKatpaSSLVKAPVNRRLLLLFAAFTLLFAANSMYIIAMPLYVTNELGGSESWVGLLF---GLAAALEIPimlLAGLLA 259
|
250 260
....*....|....*....|....*
gi 1302188055 226 DKMPtlRKWLLVFGNLITAGCYMLL 250
Cdd:cd17471 260 KRFG--KRRLLLAGFLAGVLFYLGL 282
|
|
| MFS_1 |
pfam07690 |
Major Facilitator Superfamily; |
170-370 |
2.08e-06 |
|
Major Facilitator Superfamily;
Pssm-ID: 429598 [Multi-domain] Cd Length: 344 Bit Score: 49.34 E-value: 2.08e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 170 LAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVFGNLITAGCYML 249
Cdd:pfam07690 1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFG--RRRVLLIGLLLFALGLLL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 250 LGPVpllhikSQLWLLVLVLVVNGISAGMSIIPTFPemLSCAYANGFEdsistLGLVSGLFGAMWSVGAFMGPILGGFLC 329
Cdd:pfam07690 79 LLFA------SSLWLLLVLRVLQGLGAGALFPAALA--LIADWFPPEE-----RGRALGLVSAGFGLGAALGPLLGGLLA 145
|
170 180 190 200
....*....|....*....|....*....|....*....|.
gi 1302188055 330 EKIGFEWAAAMQGLWTLLSGVsmaLFYLWEDSTARRRSKAQ 370
Cdd:pfam07690 146 SLFGWRAAFLILAILSLLAAV---LLLLPRPPPESKRPKPA 183
|
|
| MFS_SLC22A18 |
cd17331 |
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; ... |
9-203 |
2.41e-06 |
|
Solute carrier family 22 member 18 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 18 (SLC22A18) is also called Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein (BWR1A or BWSCR1A), efflux transporter-like protein, imprinted multi-membrane-spanning polyspecific transporter-related protein 1 (IMPT1), organic cation transporter-like protein 2 (ORCTL2), or tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein (TSSC5). It is localized at the apical membrane surface of renal proximal tubules and may act as an organic cation/proton antiporter. It functions as a tumor suppressor in several cancer types including glioblastoma and colorectal cancer. SLC22A18 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340889 [Multi-domain] Cd Length: 382 Bit Score: 49.14 E-value: 2.41e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 9 YALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLDQLPegpifiaMCFLVRIVDAI--GFGAAITASSSILA 86
Cdd:cd17331 44 FSVLQLVGGPLFGRFGDLFGPRAALVLSFLSSALSYLLLAFASSVP-------MLFLSRLPSVFmhAMQAAQMVVTDLTD 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 87 kafPNNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLNLYILPSYE------------SDPG 154
Cdd:cd17331 117 ---PGERAAALGRLGLSYGIGMVVGSFLGGLLTKKFGEQAAALVAAVGSLLSIVLVILLIPSNTkskrekeakesaSPPS 193
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1302188055 155 KQSFWKLVTL---PKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLS---TGYV 203
Cdd:cd17331 194 VFNLKEILRLlrlPGVAFLLLVKLLSGLPIGMFQSMFSLVAMDFFGLTpeeNGYL 248
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
1-350 |
3.39e-06 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 48.71 E-value: 3.39e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 1 MIGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLDQLPegPIFIAMCFlvrivdaIGFGAAI-- 78
Cdd:cd17478 32 QAGLLVSVFSITSSLLQPLFGYLADRKPRRYLLPLGPLLTGLGLSLLGFAPNYW--LLLLLVAL-------AGIGSAAfh 102
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 79 TASSSILAKAFPNNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLG----CIVLLMIPLNLYILPSYESDPG 154
Cdd:cd17478 103 PEGARLASQAAGGRRGLAMSIFSVGGNLGFALGPLIAAALVALFGGLGLLILLIipglAVALLLLRLRPLKKPEAKKAAA 182
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 155 KQSFWKLVTLPKMGLLAFVIISLSSCFGFLDPT--LSLFVMEKFS--LSTGYVGLVFLGLSlsyAISSPLFGLLSDKMPt 230
Cdd:cd17478 183 KSSARSTLKGVWRALLLLLIIVFLRSWVLSSLTtfLPFYLVQRGYslVFAGLLLSLFLFAG---AIGTLIGGPLSDRFG- 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 231 lRKWLLVFGNLITAGCYMLLgpvpllhIKSQLWLLVLVLVVNGISAGMSiiptFPEMLSCAYangfEDSISTLGLVSGL- 309
Cdd:cd17478 259 -RRRVIIASLLLAAPFLLLF-------LLTPGIWSYILLVLAGFLLFAS----FPVTVVLAQ----ELLPGNVGLASGLm 322
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 1302188055 310 FGAMWSVGAFMGPILgGFLCEKIGFEWAAAMQGLWTLLSGV 350
Cdd:cd17478 323 MGLSFGLGGIGAPVL-GALADAFGLESVLLILALLPLLGAL 362
|
|
| MFS_MMR_MDR_like |
cd17321 |
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ... |
9-341 |
3.95e-06 |
|
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340879 [Multi-domain] Cd Length: 370 Bit Score: 48.32 E-value: 3.95e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 9 YALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLdqlPEGPIFIAMcflvRIVDAIGFGAAITASSSILAKA 88
Cdd:cd17321 40 YLLAFAALLLLAGRLGDRFGRKRVFLIGLALFGLASLLCALA---PSLAFLIAA----RALQGIGAAAIMPASLALIAAT 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 89 FP-NNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLnlyilpsyesdpgkqsfwklvtLPKM 167
Cdd:cd17321 113 FPgERRGRALGLWGAVVGIGAALGPLLGGLLLELFGWRWIFLINVPIGLVALLL----------------------ARTF 170
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 168 GLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPTlrKWLLVFGNLITA-GC 246
Cdd:cd17321 171 SGAVLAAFLLGAALGGLLFLLPLYLQGVLGYSPLQAGLALLPLALAMLVAAPLAGRLADRFGP--RLVLVAGLLLTAvGL 248
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 247 YMLLgpvpLLHIKSQLWLLVLVLVVNGISAGMSIIPTFPEMLSCAYANgfedsisTLGLVSGLFGAMWSVG-----AFMG 321
Cdd:cd17321 249 LLLA----LLGADSSVWLLLPGLVLLGLGLGLFATPLTNAALSSVPKE-------KAGAASGILNTARQLGgalgvALLG 317
|
330 340
....*....|....*....|
gi 1302188055 322 PILGGFLCEKIGFEWAAAMQ 341
Cdd:cd17321 318 ALLTAGLSANLGDSGVAALL 337
|
|
| MFS_MdtG_SLC18_like |
cd17325 |
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ... |
170-384 |
7.48e-06 |
|
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340883 [Multi-domain] Cd Length: 375 Bit Score: 47.57 E-value: 7.48e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 170 LAFVIISLSSCFGFLDPTLSLFvMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMptLRKWLLVFGNLITAGCYML 249
Cdd:cd17325 1 LSLALFLDMLGYGIIIPILPLY-AESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRF--GRKRLLLLGLLLLAVSTLL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 250 LGpvpllhIKSQLWLLVLVLVVNGISAGMsIIPTFPEMLSCAYANGfedsisTLGLVSGLFGAMWSVGAFMGPILGGFLC 329
Cdd:cd17325 78 FA------FATSYWQLLLARFLQGLASAA-VWPAAMALIADIAPPE------ERGRAMGIFSSAIGLGFLIGPLLGGLLA 144
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*
gi 1302188055 330 EKIGFEWAAAMQGLWTLLSGVsMALFYLWEDSTARRRSKAQNSLGTEEERAALLP 384
Cdd:cd17325 145 DALGYRAPFLVCAALALLALV-LALLLLPEPRPPPNKRAVSAARLRSGLRLLLRD 198
|
|
| AraJ |
COG2814 |
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism]; |
167-371 |
5.04e-05 |
|
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
Pssm-ID: 442063 [Multi-domain] Cd Length: 348 Bit Score: 44.96 E-value: 5.04e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 167 MGLLAFVIISLSSCFGFLDPTLSLFvMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVFGNLITAGC 246
Cdd:COG2814 12 LLALALGAFLSGLGIGIVLPALPLI-AADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFG--RRRVLLLGLLLFALG 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 247 YMLLGPVPllhiksQLWLLVLVLVVNGISAGMSIIPTFPEMLSCAyangfedSISTLGLVSGLFGAMWSVGAFMGPILGG 326
Cdd:COG2814 89 SLLCALAP------SLWLLLAARFLQGLGAGALFPAALALIADLV-------PPERRGRALGLLGAGLGLGPALGPLLGG 155
|
170 180 190 200
....*....|....*....|....*....|....*....|....*
gi 1302188055 327 FLCEKIGFEWAAAMQGLWTLLSGVsMALFYLWEDSTARRRSKAQN 371
Cdd:COG2814 156 LLADLFGWRWVFLVNAVLALLALL-LLLRLLPESRPAARARLRGS 199
|
|
| MFS_Set |
cd17471 |
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ... |
169-375 |
5.13e-05 |
|
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341024 [Multi-domain] Cd Length: 371 Bit Score: 44.85 E-value: 5.13e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 169 LLAFVIISLSscFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPTlRKWLLVFGNLITAGCYM 248
Cdd:cd17471 2 LLATLLTGLA--GAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGD-RKPLILLALLAGALGYL 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 249 LLGpvpllHIKSQLWLLVLVLVVNGISAgmsiiPTFPEMLSCAYANGFEDSISTLGLVSGLFGAMWSVGAFMGPILGGFL 328
Cdd:cd17471 79 LFA-----FLRNYWVLLLVGVVLLSLGA-----AAFPQLFALAREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLL 148
|
170 180 190 200
....*....|....*....|....*....|....*....|....*..
gi 1302188055 329 CEKIGFEWAAAMQGLWTLLSGVsMALFYLWEDSTARRRSKAQNSLGT 375
Cdd:cd17471 149 LDVLGFTGLFLLAALLYLVVAL-LVLFLLPSVKPPAQKATPASSLVK 194
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
1-124 |
6.50e-05 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 44.89 E-value: 6.50e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 1 MIGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLDQLPEGPIFIAMCFLvrivdAIGFGAAITA 80
Cdd:COG2211 265 LVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLGPGNLWLLLVLAALA-----GIGLGAILVL 339
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|..
gi 1302188055 81 SSSILAKAFP--------NNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGY 124
Cdd:COG2211 340 PWAMLADVVDydewktgrRREGLYFGIFTFAIKLGQALAGALAGLLLALFGY 391
|
|
| MFS_arabinose_efflux_permease_like |
cd17473 |
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; ... |
1-357 |
7.03e-05 |
|
Putative arabinose efflux permease family transporters of the Major Facilitator Superfamily; This family includes a group of putative arabinose efflux permease family transporters, such as alpha proteobacterium quinolone resistance protein NorA (characterized Staphylococcus aureus Quinolone resistance protein NorA belongs to a different group), Desulfovibrio dechloracetivorans bacillibactin exporter, Vibrio aerogenes antiseptic resistance protein. The biological function of those transporters remain unclear. They belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341026 [Multi-domain] Cd Length: 374 Bit Score: 44.49 E-value: 7.03e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 1 MIGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLDQLPegPIFIAmcflvRIVDAIGFGAAITA 80
Cdd:cd17473 36 LVPLLLTLPALFIALFAPLAGWLADRFGRKRLLIAGLLLYGIGGVAGLFLDSLY--ALLAS-----RALLGIGVAGIMTL 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 81 SSSILAKAFPNNV-ATVMGSLEVFSGLGLVAGPPLGGLLyQSFGYEVPFIFLGcIVLLMIPLNLYILPSYE----SDPGK 155
Cdd:cd17473 109 ATALIGDYFEGEErAKMLGLQSAAMSLGGVVFLLLGGAL-AEIGWRAPFLVYL-LALPVLILVLLFLPEPArkskSAASP 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 156 QSFWKLVTLPKMGLLAFVIISLSSCFGFLDPT-LSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKW 234
Cdd:cd17473 187 GAATAAALPWKRVLPIYFLAFLAMLLFYVIPIqLPFLLQERGGGSAALIGLALAIASLAGAIGALLFGRLKRRLG--KRR 264
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 235 LLVFGNLITAGCYMLLGpvpllhIKSQLWLLVLVLVVNGISAGMsIIPTFPEMLSCAYangfedSISTLGLVSGLFGAMW 314
Cdd:cd17473 265 LLAIGFALMALGFLLLA------LASGLWVVLLGAILAGLGFGL-LLPTLNSWAMSLV------PPELRGRAMGIVTSAF 331
|
330 340 350 360
....*....|....*....|....*....|....*....|...
gi 1302188055 315 SVGAFMGPILGGFLcEKIGFEWAAAMQGLWTLLSGVSMALFYL 357
Cdd:cd17473 332 FLGQFLSPLVLGPL-VNLTGGLSGAFLILGVLALVLAIVLLLL 373
|
|
| CynX |
COG2807 |
Cyanate permease [Inorganic ion transport and metabolism]; |
1-357 |
2.63e-04 |
|
Cyanate permease [Inorganic ion transport and metabolism];
Pssm-ID: 442057 [Multi-domain] Cd Length: 399 Bit Score: 42.94 E-value: 2.63e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 1 MIGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLDQlpegpifIAMCFLVRIVDAIGFGAAITA 80
Cdd:COG2807 54 QAGLLTTLPLLAFGLFAPLAPRLARRFGLERTLLLALLLLAAGLLLRSLAPS-------VALLLAGTALIGAGIAVGNVL 126
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 81 SSSILAKAFPNNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLNLYIL----PSYESDPGKQ 156
Cdd:COG2807 127 LPGLIKRWFPDRVGLMTGLYTAAMGLGAALAAGLTVPLAAALGWRGALAVWALLALLALLLWLPLLrrrpAAAAAAPAAA 206
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 157 SFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKfSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPTLRKWLL 236
Cdd:COG2807 207 SLRSLWRSPLAWLLTLFFGLQSLLYYAVVAWLPPILRDA-GLSAATAGLLLSLFQLAGIPGSLLVPLLADRLGDRRPLLL 285
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 237 VFGNLITAGCY-MLLGPVPLLHiksqLWLLVLvlvvnGISAGMSIIptfpemLSCAYANGFEDSISTLGLVSGLFGAMWS 315
Cdd:COG2807 286 LLGLLGLAGLLgLLLAPGSLPW----LWAVLL-----GLGQGGLFP------LALTLIGLRARTPAEAAALSGMAQSVGY 350
|
330 340 350 360
....*....|....*....|....*....|....*....|..
gi 1302188055 316 VGAFMGPILGGFLcekigFEWAAAMQGLWTLLSGVSMALFYL 357
Cdd:COG2807 351 LLAALGPLLVGAL-----HDATGSWTAALLLLAALAVLMLVA 387
|
|
| MFS_LmrB_MDR_like |
cd17503 |
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) ... |
60-282 |
3.90e-04 |
|
Bacillus subtilis lincomycin resistance protein (LmrB) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including Bacillus subtilis lincomycin resistance protein LmrB, and several proteins from Escherichia coli such as the putative MDR transporters EmrB, MdtD, and YieQ. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341046 [Multi-domain] Cd Length: 380 Bit Score: 42.18 E-value: 3.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 60 IAMCFLVRIVDAIGFGAAITASSSILAKAFPNN-VATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIF---LGCIV 135
Cdd:cd17503 84 LASLIIFRILQGFGGGVLIPLAQTILLRIYPPEkRGAAMGLVGLVILLAPAIGPTLGGWLTDNLSWRWIFYInlpIGILA 163
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 136 LLMIP-LNLYILpsyesdpgkqsfwKLVTLPKMGLLAFVIISLSSCFGFLdptLSLFVMEKFSLSTGYVGLVFLGLSLSY 214
Cdd:cd17503 164 LLLAPlLDLRLF-------------KDRNFTLGLLLSFLLGLGLFGAMFL---LPLYLQNVLGYSAFESGLVLAPGGLAS 227
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1302188055 215 AISSPLFGLLSDKMPTlrKWLLVFGNLITAGCYMLLGpvpLLHIKSQLWLLVLVLVVNGISAGMSIIP 282
Cdd:cd17503 228 AILSPLVGRLLDKFGP--RLLLLAGLLLLALGTLLLA---FLTPDTSLWLIILPLFIRGLGMGLVFMP 290
|
|
| MFS_FsR |
cd17478 |
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ... |
182-375 |
4.68e-04 |
|
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 341031 [Multi-domain] Cd Length: 365 Bit Score: 41.77 E-value: 4.68e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 182 GFLDPTLSLFVmEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVFGNLITAGCYMLLGPVPllhiksQ 261
Cdd:cd17478 13 GFLPALLPLLI-AKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKP--RRYLLPLGPLLTGLGLSLLGFAP------N 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 262 LWLLVLVLVVNGISAGMsiiptF-PEmlSCAYANGFEDSISTLGLvsGLFGAMWSVGAFMGPILGGFLCEKigfeWAAAM 340
Cdd:cd17478 84 YWLLLLLVALAGIGSAA-----FhPE--GARLASQAAGGRRGLAM--SIFSVGGNLGFALGPLIAAALVAL----FGGLG 150
|
170 180 190
....*....|....*....|....*....|....*
gi 1302188055 341 QGLWTLLSGVSMALFYLWEDSTARRRSKAQNSLGT 375
Cdd:cd17478 151 LLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSS 185
|
|
| MFS_OFA_like |
cd17353 |
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of ... |
1-335 |
5.96e-04 |
|
Oxalate:formate antiporter (OFA) and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Oxalobacter formigenes oxalate:formate antiporter (OFA or OxlT) and similar proteins. O. formigenes, a commensal found in the gut of animals and humans, plays an important role in clearing dietary oxalate from the intestinal tract, which is carried out by OFA/OxlT, an anion transporter that facilitates the exchange of divalent oxalate with monovalent formate, the product of oxalate decarboxylation. This exchange generates an electrochemical proton gradient and is the source of energy for ATP synthesis in this cell. The OFA-like subfamily belongs to the Monocarboxylate transporter -like (MCT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340911 [Multi-domain] Cd Length: 389 Bit Score: 41.44 E-value: 5.96e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 1 MIGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLDQLPegpifiAMCFLVRIVDAIGFGAAITA 80
Cdd:cd17353 39 SVALAFTLTIVFLAISAPFAGRLVDRGGPRKAILIGGILFGLGFILSAFAISLP------LLFLGYGVLGGIGAGIGYIT 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 81 SSSILAKAFPNNVATVMGSleVFSGLGLVAGP--PLGGLLYQSFGYEVPFIFLGCIVLLMIPLNLYIL------------ 146
Cdd:cd17353 113 PVSTAVKWFPDKRGLATGI--VIAGFGLGSLIfsPLIAYLINTVGVPTTFLILGIIFLIIIVIGAFLIrdppkgwvppgv 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 147 ----PSYESDPGKQSFWKLVTLPKMGLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFG 222
Cdd:cd17353 191 dplaNNAENSPRDYTPREMLRTPTFWLLWLMFFLNATAGLMLIGQAKPIGQEFAGLDAGIAALAVSILSIFNGGGRPFWG 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 223 LLSDKMPtlRKWLLVFGNLITAGCYMLLGPVPLLHIKSQLWLLVLVlvvngiSAGMSIIPTFPEMLSCAYANGFedsist 302
Cdd:cd17353 271 WLSDKIG--RKNTLSIAFLIQGVAMFLLPFIGSVAVLFVLGVALIG------FCYGGGFALFPALTADFFGTKN------ 336
|
330 340 350
....*....|....*....|....*....|...
gi 1302188055 303 LGLVSGLFGAMWSVGAFMGPILGGFLCEKIGFE 335
Cdd:cd17353 337 AGTNYGLLYTAKGVGGLIGPIIAAYVLYTGGYN 369
|
|
| MFS_MefA_like |
cd06173 |
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ... |
1-282 |
1.08e-03 |
|
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340863 [Multi-domain] Cd Length: 383 Bit Score: 40.68 E-value: 1.08e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 1 MIGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLDQLPEGPIFIAMCFLVriVDAIGFGAAITA 80
Cdd:cd06173 35 LVGLVLAAFFLPFLLFSPFAGVLADRFDRRRLLILADLLRALLAAVLALLALLGSLSLWLLLVLAF--LLGIASAFFGPA 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 81 SSSILAKAFP-NNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLNLYILPSYESDPGKQSF- 158
Cdd:cd06173 113 RQALLPELVPkEQLVRANALNSLATQLARIIGPALGGLLVALLGPGGAFAINALSFLLSALLLLFIRRPPPAAPGESSSl 192
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 159 --------WKLVTLPKMGLLAFVIISLSSCFGFLDPTLS-LFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMP 229
Cdd:cd06173 193 llrdlregLRYLRRSPLLRLLLLALALFALLGGALTVLLpLLAKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRR 272
|
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|...
gi 1302188055 230 tlRKWLLVFGNLITAGCYMLLGPVPllhiksQLWLLVLVLVVNGISAGMSIIP 282
Cdd:cd06173 273 --RGRLLLIGALLLGLALLVLGLSP------SLWLLLAALFLLGLAGGLFNVP 317
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
2-147 |
1.39e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 40.24 E-value: 1.39e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 2 IGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAgMFVSGGVTILFGVLDQLPEGPIFIAMCFLVrivdAIGFGAAITAS 81
Cdd:COG2271 218 AGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVL-AIGLLLAALALLLLALLPSPALAIALLFLA----GFGLGGAFGLL 292
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1302188055 82 SSILAKAFP-NNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLNLYILP 147
Cdd:COG2271 293 WALAAELFPkKARGTASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAALLALLLLR 359
|
|
| MFS_SV2_like |
cd17316 |
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ... |
2-251 |
2.29e-03 |
|
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340874 [Multi-domain] Cd Length: 353 Bit Score: 39.51 E-value: 2.29e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 2 IGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLDqlpeGPIFIamcFLVRIVDAIGFGAAITAS 81
Cdd:cd17316 38 TGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLLP----TPILL---LVLRFLQGIGIGGEYPGA 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 82 SSILAKAFPNNVATVMGS-LEVFSGLGLVAGPPLGGLLYQSFGYE----VPFIFLGCIVLLMIPLNLYILpsyesdpgkq 156
Cdd:cd17316 111 STYVAEFAPSKRRGFALGlLQSGWALGALLAALVASLLIPLLSGDwgwrILFLIGALPALLALLLRRRTL---------- 180
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 157 sfwklvtlpkmgLLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLL 236
Cdd:cd17316 181 ------------LLILLWFFISFGYYGLTTFLPTYLQTVLGLSPATSSLYLLLISLGALVGALIAGLLSDRIG--RKKTL 246
|
250
....*....|....*
gi 1302188055 237 VFGNLITAGCYMLLG 251
Cdd:cd17316 247 VIGLILSGILALPLF 261
|
|
| UhpC |
COG2271 |
Sugar phosphate permease [Carbohydrate transport and metabolism]; |
163-350 |
3.07e-03 |
|
Sugar phosphate permease [Carbohydrate transport and metabolism];
Pssm-ID: 441872 [Multi-domain] Cd Length: 363 Bit Score: 39.47 E-value: 3.07e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 163 TLPKMGLLAFVIISLSSCFGFLD----PTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVF 238
Cdd:COG2271 3 APSRYRWRILALLFLAYFLNYLDrsnlSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFG--RRRVLAI 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 239 GNLITAGCYMLLGPVPllhiksQLWLLVLVLVVNGISAGMsiiptfpEMLSCAYANGFEDSISTLGLVSGLFGAMWSVGA 318
Cdd:COG2271 81 GLLLWGLATLLFGFAT------SFWQLLLLRFLLGLGEAG-------FFPAALKLIAEWFPPKERGRALGIFNAGGPLGG 147
|
170 180 190
....*....|....*....|....*....|..
gi 1302188055 319 FMGPILGGFLCEKIGFEWAAAMQGLWTLLSGV 350
Cdd:COG2271 148 ALAPPLLGWLLAAFGWRAAFLILGLPGLLLAL 179
|
|
| MFS_MFSD9 |
cd17390 |
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ... |
1-149 |
3.25e-03 |
|
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340948 [Multi-domain] Cd Length: 350 Bit Score: 39.13 E-value: 3.25e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 1 MIGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLDQLpegpifiAMCFLVRIVDAIgFGAAITA 80
Cdd:cd17390 32 VIGLIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFSTSL-------ALLFLSRIPLGI-FKHTQSL 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1302188055 81 SSSILAKAFPNN-VATVMGSLEVFSGLGLVAGPPLGGLLYQ-SFGYEVPFIFLGCIVLLMIPLNLYILPSY 149
Cdd:cd17390 104 CKAYLSDLVSEQeRSRVLGRFNAASSLGFILGPVVGGHLAEtDGGFYYVALLCSAIFILNAGLVWFLLSKL 174
|
|
| MFS_TetA |
cd17388 |
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily ... |
62-216 |
4.03e-03 |
|
Tetracycline resistance protein TetA and related proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of tetracycline resistance proteins similar to Escherichia coli TetA(A), TetA(B), and TetA(E), which are metal-tetracycline/H(+) antiporters that confer resistance to tetracycline by an active tetracycline efflux, which is an energy-dependent process that decreases the accumulation of the antibiotic in cells. TetA-like tetracycline resistance proteins belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340946 [Multi-domain] Cd Length: 385 Bit Score: 39.16 E-value: 4.03e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 62 MCFLVRIVDAIGFGAAITASSSILAKAFPNNVATVMGSLEVFSGLGLVAGPPLGGLLYQsFGYEVPFIFLGCIVLLMIPL 141
Cdd:cd17388 93 WLYLGRIIAGITGATGAVAAAYIADVTPPEQRARNFGLLGAAFGLGFIAGPALGGLLGE-ISPRAPFLVAAGLNGLNFLL 171
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 142 NLYILPsyESDPGKQ-------------SFWKLVTLPKMG--LLAFVIISLSSCFGFldPTLSLFVMEKFSLSTGYVGLV 206
Cdd:cd17388 172 GLFVLP--ESLPPERrrafrwrranpfgSLRWLTGFPGLLglLAVFFLIQLIGQVPA--TTWVLFTEDRFDWSPTMVGLS 247
|
170
....*....|
gi 1302188055 207 FLGLSLSYAI 216
Cdd:cd17388 248 LAVFGLLHAL 257
|
|
| MFS_MdtH_MDR_like |
cd17329 |
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ... |
180-354 |
5.55e-03 |
|
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340887 [Multi-domain] Cd Length: 376 Bit Score: 38.36 E-value: 5.55e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 180 CFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVFGNLITAGCYMLLGpvpllhIK 259
Cdd:cd17329 14 GFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFG--RKPVMLAGLLLRALGFALLG------FA 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 260 SQLWLLVLVLVVNGISAGMsIIPTFPEMLSCAYANGfedsisTLGLVSGLFGAMWSVGAFMGPILGGFLCEkIGFEWAAA 339
Cdd:cd17329 86 HSPWLFAIALVLTGFGGGL-FEPASEAMIADVTTPE------NRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFL 157
|
170
....*....|....*
gi 1302188055 340 MQGLWTLLSGVSMAL 354
Cdd:cd17329 158 AAAVLFLLAALVLLF 172
|
|
| FucP |
COG0738 |
Fucose permease [Carbohydrate transport and metabolism]; |
169-358 |
5.78e-03 |
|
Fucose permease [Carbohydrate transport and metabolism];
Pssm-ID: 440501 [Multi-domain] Cd Length: 391 Bit Score: 38.68 E-value: 5.78e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 169 LLAFVIISLSSCFGFLDPtLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVFGNLITAGCYM 248
Cdd:COG0738 12 AIYLLFFLWGFATALWGP-LIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFG--YKRGLLLGLLLMALGLL 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 249 LLGPVPllhiksQLWLLVLVLVVNGISAGMSIIPTFPEMLSCAYANGfedsistlGLVSGLFGAMWSVGAFMGPILGGFL 328
Cdd:COG0738 89 LFALAP------SYPLLLLALFLLGLGLGLLDVAANPYVAALGPETA--------ASRLNLLHAFFSLGALLGPLLGGLL 154
|
170 180 190
....*....|....*....|....*....|
gi 1302188055 329 cekIGFEWAAAMQGLWTLLSGVSMALFYLW 358
Cdd:COG0738 155 ---ILLGLSLSWHLPYLILAVLLLLLALLF 181
|
|
| MFS_NepI_like |
cd17324 |
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ... |
1-139 |
6.68e-03 |
|
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340882 [Multi-domain] Cd Length: 370 Bit Score: 38.30 E-value: 6.68e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 1 MIGMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFVSGGVTILFGVLdqlPEGPIFIAMCFLVrivdAIGFGAAITA 80
Cdd:cd17324 235 AIIGLLLLFGVAGVVGSPLAGRLADRGGRRALLIALLLLAAALLLLTLLG---PSPLLLLVGLVLW----GLGFFAAHSA 307
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 1302188055 81 SSSILAKAFPNNVATVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMI 139
Cdd:cd17324 308 LQTRVLRLAPEARGLASSLYLAAYNLGGALGAALGGLVLDHGGWAGVGWVGAALLLLAL 366
|
|
| MFS_MdtG_MDR_like |
cd17391 |
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the ... |
3-336 |
9.14e-03 |
|
Multidrug resistance protein MdtG and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli multidrug resistance protein MdtG, Streptococcus pneumoniae multidrug resistance efflux pump PmrA, and similar multidrug resistance (MDR) transporters from bacteria. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtG confers resistance to fosfomycin and deoxycholate. PmrA serves as an efflux pump for various substrates and is associated with fluoroquinolone resistance. MdtG-like MDR transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.
Pssm-ID: 340949 [Multi-domain] Cd Length: 380 Bit Score: 38.01 E-value: 9.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 3 GMIFGCYALFELLASLVFGKYLVHIGAKFMFIAGMFvsgGVTILFGVLDQLPEGPIFIAMCFLVRIvdaigFGAAITASS 82
Cdd:cd17391 39 GLAFSSTFLVSAIFSPIWGRLADRYGRKPMLLRASL---GMAIVIGLMAFVTNVWQLLILRLLQGV-----FSGYVPNAT 110
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 83 SILAKAFPNNVA-TVMGSLEVFSGLGLVAGPPLGGLLYQSFGYEVPFIFLGCIVLLMIPLNLYIL------PSYESDPGK 155
Cdd:cd17391 111 ALIASQTPKEKSgWALGTLSTGVVAGTLIGPLLGGFLADLFGIRNVFFITGGLLFLAFLLTLFFVkedfkpVEKKKMVST 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 156 QSFWKLVTLPKMGLLAFVI-ISLSSCFGFLDPTLSLFVME---KFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPTL 231
Cdd:cd17391 191 KEVWNSVPNPSLLISLFVTtFIIQLANQSIEPILTLYIRQlmgDASNLAFISGLVFSATGVSSLLSAPRLGKLGDRIGHH 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 232 RkwLLVFGNLITAGCYMLLGPVpllhikSQLWLLVLVLVVNGISAGmSIIPTFPEMLSCAYANGFEDSIstLGLVSGLFg 311
Cdd:cd17391 271 R--ILLGALLASALLYIPQAFV------QTPWQLGILRFLLGLATG-GLLPAINSLLAKITPKEVAGRI--FGYNQSFQ- 338
|
330 340
....*....|....*....|....*
gi 1302188055 312 amwSVGAFMGPILGGFLCEKIGFEW 336
Cdd:cd17391 339 ---YLGNVAGPLLGSAIAAHFGYRA 360
|
|
| MelB |
COG2211 |
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism]; |
181-358 |
9.46e-03 |
|
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
Pssm-ID: 441813 [Multi-domain] Cd Length: 447 Bit Score: 37.96 E-value: 9.46e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 181 FGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPTL---RKWLLVFGNLITAGCYMLLGPVPLLH 257
Cdd:COG2211 26 FGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgrRRPWILIGAIPLALSFVLLFTAPDLS 105
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188055 258 IKSQLWLLVLVLVVNGISAGMSIIPTfpEMLSCAYANGFEDSIStlglVSGLFGAMWSVGAFMGPILGGFLCEKIGFEWA 337
Cdd:COG2211 106 PTGKLIYALVTYLLLGLAYTLVNIPY--SALGAELTPDYEERTR----LSSWRFAFAGLGGLLASVLPPPLVAAFGGDAA 179
|
170 180
....*....|....*....|.
gi 1302188055 338 AAMQgLWTLLSGVSMALFYLW 358
Cdd:COG2211 180 LGYR-LTALIFAVLGLLAFLL 199
|
|
| |
