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Conserved domains on  [gi|1302188124|ref|NP_001345742|]
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MFS-type transporter SLC18B1 isoform 3 [Mus musculus]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 3-190 6.11e-75

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17385:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 390  Bit Score: 231.34  E-value: 6.11e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124   3 LLAFVIISLSSCFGFLDPTLSLFVmEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtLRKWLLVFGNLITAGCYM 82
Cdd:cd17385   205 LLCLSIVSGSVSLGFLDPTLSPHL-RQFKLSPGQVGLMFLILAGSYAISAPLWGWLSDKKK-IPKWLMVIGSIITGVGFL 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  83 LLGPVPLLHIKSQLWLLVLVLVVNGISAGMSIIPTFPEMLSCAYANGFEDSISTLGLVSGLFGAMWSVGAFMGPILGGFL 162
Cdd:cd17385   283 LLGPAPLLPIKSELWMVIIGLVLLGLSLGAALVPTFPELLNCAREYGFPDNLSTYGLVSGLFNAAFSLGAFIGPTLGGFL 362

                         170       180
                  ....*....|....*....|....*...
gi 1302188124 163 CEKIGFEWAAAMQGLWTLLSGVSMALFY 190
Cdd:cd17385   363 LERLGFEWAATIQAGLAFVVGILMSIYY 390
 
Name Accession Description Interval E-value
MFS_SLC18B1 cd17385
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...
 3-190 6.11e-75

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340943 [Multi-domain]  Cd Length: 390  Bit Score: 231.34  E-value: 6.11e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124   3 LLAFVIISLSSCFGFLDPTLSLFVmEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtLRKWLLVFGNLITAGCYM 82
Cdd:cd17385   205 LLCLSIVSGSVSLGFLDPTLSPHL-RQFKLSPGQVGLMFLILAGSYAISAPLWGWLSDKKK-IPKWLMVIGSIITGVGFL 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  83 LLGPVPLLHIKSQLWLLVLVLVVNGISAGMSIIPTFPEMLSCAYANGFEDSISTLGLVSGLFGAMWSVGAFMGPILGGFL 162
Cdd:cd17385   283 LLGPAPLLPIKSELWMVIIGLVLLGLSLGAALVPTFPELLNCAREYGFPDNLSTYGLVSGLFNAAFSLGAFIGPTLGGFL 362

                         170       180
                  ....*....|....*....|....*...
gi 1302188124 163 CEKIGFEWAAAMQGLWTLLSGVSMALFY 190
Cdd:cd17385   363 LERLGFEWAATIQAGLAFVVGILMSIYY 390
MFS_1 pfam07690
Major Facilitator Superfamily;
4-208 1.57e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 53.58  E-value: 1.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124   4 LAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVFGNLITAGCYML 83
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFG--RRRVLLIGLLLFALGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  84 LGPVpllhikSQLWLLVLVLVVNGISAGMSIIPTFPemLSCAYANGFEdsistLGLVSGLFGAMWSVGAFMGPILGGFLC 163
Cdd:pfam07690  79 LLFA------SSLWLLLVLRVLQGLGAGALFPAALA--LIADWFPPEE-----RGRALGLVSAGFGLGAALGPLLGGLLA 145

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1302188124 164 EKIGFEWAAAMQGLWTLLSGVsmaLFYLWEDSTARRRSKAQNSLG 208
Cdd:pfam07690 146 SLFGWRAAFLILAILSLLAAV---LLLLPRPPPESKRPKPAEEAR 187
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
3-189 2.91e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 49.87  E-value: 2.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124   3 LLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPTLRKWLLVFGNLITAGCYM 82
Cdd:COG2271   184 LLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALL 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  83 LLGPVPllhiksQLWLLVLVLVVNGISAGMSIIPTFPEMLSCAyangfedSISTLGLVSGLFGAMWSVGAFMGPILGGFL 162
Cdd:COG2271   264 LLALLP------SPALAIALLFLAGFGLGGAFGLLWALAAELF-------PKKARGTASGLVNTFGFLGGALGPLLVGYL 330

                         170       180
                  ....*....|....*....|....*..
gi 1302188124 163 CEKIGFEWAAAMQGLWTLLSGVSMALF 189
Cdd:COG2271   331 LDATGYQAAFLLLAALALLAALLALLL 357
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 28-112 8.71e-03

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 36.58  E-value: 8.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  28 EKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPTlrKWLLVFGNLITAGCYMLLGPVPllhiksQLWLLVLVLVVNG 107
Cdd:TIGR00881  23 EEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNP--RVFLPIGLILCAIVNLFFGFST------SLWVMAALWALNG 94


                  ....*
gi 1302188124 108 ISAGM 112
Cdd:TIGR00881  95 IFQGM 99
 
Name Accession Description Interval E-value
MFS_SLC18B1 cd17385
Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; ...
 3-190 6.11e-75

Solute carrier family 18 member B1 of the Major Facilitator Superfamily of transporters; Solute carrier family 18 member B1 (SLC18B1) is the fourth member of the SLC18 transporter family, which includes vesicular monoamine transporters and vesicular acetylcholine transporter. It is predominantly expressed in the hippocampus and is associated with vesicles in astrocytes. It actively transports spermine and spermidine by exchange of H(+), and has been suggested to be a vesicular polyamine transporter (VPAT). SLC18B1 belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340943 [Multi-domain]  Cd Length: 390  Bit Score: 231.34  E-value: 6.11e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124   3 LLAFVIISLSSCFGFLDPTLSLFVmEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtLRKWLLVFGNLITAGCYM 82
Cdd:cd17385   205 LLCLSIVSGSVSLGFLDPTLSPHL-RQFKLSPGQVGLMFLILAGSYAISAPLWGWLSDKKK-IPKWLMVIGSIITGVGFL 282

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  83 LLGPVPLLHIKSQLWLLVLVLVVNGISAGMSIIPTFPEMLSCAYANGFEDSISTLGLVSGLFGAMWSVGAFMGPILGGFL 162
Cdd:cd17385   283 LLGPAPLLPIKSELWMVIIGLVLLGLSLGAALVPTFPELLNCAREYGFPDNLSTYGLVSGLFNAAFSLGAFIGPTLGGFL 362

                         170       180
                  ....*....|....*....|....*...
gi 1302188124 163 CEKIGFEWAAAMQGLWTLLSGVSMALFY 190
Cdd:cd17385   363 LERLGFEWAATIQAGLAFVVGILMSIYY 390
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 3-190 5.89e-21

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 89.56  E-value: 5.89e-21
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124   3 LLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVFGNLITAGCYM 82
Cdd:cd17325   203 ALFLAIFVLAFAFGALEPFLPLYAAELGGLSPAQIGLLFGAQGLASALSQPPAGKLSDRIG--RKPLILIGLLLSAVALL 280

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  83 LLGPVPllhiksQLWLLVLVLVVNGISAGMSIIPTFPEMLSCAYANGfedsistLGLVSGLFGAMWSVGAFMGPILGGFL 162
Cdd:cd17325   281 LLPLAT------SFWLLLLLLALLGLGLGLVFPATLALLADIVPPEG-------RGTAMGLFNTAFSLGMVLGPLLGGFL 347

                         170       180
                  ....*....|....*....|....*...
gi 1302188124 163 CEKIGFEWAAAMQGLWTLLSGVSMALFY 190
Cdd:cd17325   348 YDAFGFATPFLAAAALLLLAAVLFLLLR 375
MFS_1 pfam07690
Major Facilitator Superfamily;
4-208 1.57e-08

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 53.58  E-value: 1.57e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124   4 LAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVFGNLITAGCYML 83
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPALPLLLAEDLGISPTEIGLLLTLFSLGYALAQPLAGRLSDRFG--RRRVLLIGLLLFALGLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  84 LGPVpllhikSQLWLLVLVLVVNGISAGMSIIPTFPemLSCAYANGFEdsistLGLVSGLFGAMWSVGAFMGPILGGFLC 163
Cdd:pfam07690  79 LLFA------SSLWLLLVLRVLQGLGAGALFPAALA--LIADWFPPEE-----RGRALGLVSAGFGLGAALGPLLGGLLA 145

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1302188124 164 EKIGFEWAAAMQGLWTLLSGVsmaLFYLWEDSTARRRSKAQNSLG 208
Cdd:pfam07690 146 SLFGWRAAFLILAILSLLAAV---LLLLPRPPPESKRPKPAEEAR 187
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 4-218 1.50e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 51.04  E-value: 1.50e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124   4 LAFVIISLSSCFGFLDPTLSLFvMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMptLRKWLLVFGNLITAGCYML 83
Cdd:cd17325     1 LSLALFLDMLGYGIIIPILPLY-AESLGASVAQIGLIVAAYALAQLLFSPPAGRLSDRF--GRKRLLLLGLLLLAVSTLL 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  84 LGpvpllhIKSQLWLLVLVLVVNGISAGMsIIPTFPEMLSCAYANGfedsisTLGLVSGLFGAMWSVGAFMGPILGGFLC 163
Cdd:cd17325    78 FA------FATSYWQLLLARFLQGLASAA-VWPAAMALIADIAPPE------ERGRAMGIFSSAIGLGFLIGPLLGGLLA 144

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1302188124 164 EKIGFEWAAAMQGLWTLLSGVsMALFYLWEDSTARRRSKAQNSLGTEEERAALLP 218
Cdd:cd17325   145 DALGYRAPFLVCAALALLALV-LALLLLPEPRPPPNKRAVSAARLRSGLRLLLRD 198
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
3-189 2.91e-07

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 49.87  E-value: 2.91e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124   3 LLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPTLRKWLLVFGNLITAGCYM 82
Cdd:COG2271   184 LLALAYFLVYFALYGFLTWLPTYLVEVRGLSLAQAGLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVLAIGLLLAALALL 263

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  83 LLGPVPllhiksQLWLLVLVLVVNGISAGMSIIPTFPEMLSCAyangfedSISTLGLVSGLFGAMWSVGAFMGPILGGFL 162
Cdd:COG2271   264 LLALLP------SPALAIALLFLAGFGLGGAFGLLWALAAELF-------PKKARGTASGLVNTFGFLGGALGPLLVGYL 330

                         170       180
                  ....*....|....*....|....*..
gi 1302188124 163 CEKIGFEWAAAMQGLWTLLSGVSMALF 189
Cdd:COG2271   331 LDATGYQAAFLLLAALALLAALLALLL 357
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
1-205 1.98e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 47.66  E-value: 1.98e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124   1 MGLLAFVIISLSSCFGFLDPTLSLFvMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVFGNLITAGC 80
Cdd:COG2814    12 LLALALGAFLSGLGIGIVLPALPLI-AADLGASPAQAGLVVTAYLLGAALGAPLAGRLADRFG--RRRVLLLGLLLFALG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  81 YMLLGPVPllhiksQLWLLVLVLVVNGISAGMsIIPTFPEMLSCAYANGfedsisTLGLVSGLFGAMWSVGAFMGPILGG 160
Cdd:COG2814    89 SLLCALAP------SLWLLLAARFLQGLGAGA-LFPAALALIADLVPPE------RRGRALGLLGAGLGLGPALGPLLGG 155

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*
gi 1302188124 161 FLCEKIGFEWAAAMQGLWTLLSGVsMALFYLWEDSTARRRSKAQN 205
Cdd:COG2814   156 LLADLFGWRWVFLVNAVLALLALL-LLLRLLPESRPAARARLRGS 199
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 3-184 3.10e-06

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 47.15  E-value: 3.10e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124   3 LLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVFGNLITAGCYM 82
Cdd:cd17370   202 FWLYLLAVALFALGNFSFAFLILRAQELGLSAALIPLLYALFNLVYALAAYPAGRLSDRIG--RKKLLILGYLSLALAYL 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  83 LLGpvpllhIKSQLWLLVLVLVVNGISAGMSiiptfpEMLSCAYANGFEDSiSTLGLVSGLFGAMWSVGAFMGPILGGFL 162
Cdd:cd17370   280 GFA------LGSSLWLLLLGFILWGLYMGAQ------ESIERAAVADLVPA-ELRGTAYGLFNTVVGIGWLLASLIAGYL 346

                         170       180
                  ....*....|....*....|..
gi 1302188124 163 CEKIGFEWAAAMQGLWTLLSGV 184
Cdd:cd17370   347 WDLISPSAAFLFSAVLALIALL 368
MFS_Set cd17471
Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; ...
 3-209 5.48e-06

Sugar efflux transporter (Set) family of the Major Facilitator Superfamily of transporters; This family is composed of sugar transporters such as Escherichia coli Sugar efflux transporter SetA, SetB, SetC and other sugar transporters. SetA, SetB, and SetC are involved in the efflux of sugars such as lactose, glucose, IPTG, and substituted glucosides or galactosides. They may be involved in the detoxification of non-metabolizable sugar analogs. The Set family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341024 [Multi-domain]  Cd Length: 371  Bit Score: 46.39  E-value: 5.48e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124   3 LLAFVIISLSscFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPTlRKWLLVFGNLITAGCYM 82
Cdd:cd17471     2 LLATLLTGLA--GAFVLPYLSLFLTEELGASPLQIGIFMTLSALSGIVVSQWLGRLSDRGGD-RKPLILLALLAGALGYL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  83 LLGpvpllHIKSQLWLLVLVLVVNGISAgmsiiPTFPEMLSCAYANGFEDSISTLGLVSGLFGAMWSVGAFMGPILGGFL 162
Cdd:cd17471    79 LFA-----FLRNYWVLLLVGVVLLSLGA-----AAFPQLFALAREYADRSSGRDATLFNSVLRAAFSLAWVIGPPLAFLL 148

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*..
gi 1302188124 163 CEKIGFEWAAAMQGLWTLLSGVsMALFYLWEDSTARRRSKAQNSLGT 209
Cdd:cd17471   149 LDVLGFTGLFLLAALLYLVVAL-LVLFLLPSVKPPAQKATPASSLVK 194
MFS_FsR cd17478
Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; ...
 16-209 2.43e-05

Fosmidomycin resistance protein of the Major Facilitator Superfamily of transporters; Fosmidomycin resistance protein (FsR) confers resistance against fosmidomycin. It shows sequence similarity with the bacterial drug-export proteins that mediate resistance to tetracycline and chloramphenicol. This FsR family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341031 [Multi-domain]  Cd Length: 365  Bit Score: 44.08  E-value: 2.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  16 GFLDPTLSLFVmEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVFGNLITAGCYMLLGPVPllhiksQ 95
Cdd:cd17478    13 GFLPALLPLLI-AKLGLSYAQAGLLVSVFSITSSLLQPLFGYLADRKP--RRYLLPLGPLLTGLGLSLLGFAP------N 83

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  96 LWLLVLVLVVNGISAGMsiiptF-PEmlSCAYANGFEDSISTLGLvsGLFGAMWSVGAFMGPILGGFLCEKigfeWAAAM 174
Cdd:cd17478    84 YWLLLLLVALAGIGSAA-----FhPE--GARLASQAAGGRRGLAM--SIFSVGGNLGFALGPLIAAALVAL----FGGLG 150

                         170       180       190
                  ....*....|....*....|....*....|....*
gi 1302188124 175 QGLWTLLSGVSMALFYLWEDSTARRRSKAQNSLGT 209
Cdd:cd17478   151 LLILLIIPGLAVALLLLRLRPLKKPEAKKAAAKSS 185
MFS_SLC18A1_2_VAT1_2 cd17384
Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major ...
 3-170 4.47e-05

Vesicular amine transporters 1 (VAT1) and 2 (VAT2), and similar transporters of the Major Facilitator Superfamily; Vesicular amine transporter 1 (VAT1 or VMAT1) is also called solute carrier family 18 member 1 (SLC18A1) or chromaffin granule amine transporter, while VAT2 (or VMAT2) is also called SLC18A2, synaptic vesicular amine transporter, or monoamine transporter. VATs (or VMATs) are responsible for the uptake of cytosolic monoamines into synaptic vesicles in monoaminergic neurons. VAT1 and VAT2 distinct pharmacological properties and tissue distributions. VAT1 is preferentially expressed in neuroendocrine cells and endocrine cells, where it transports biogenic monoamines, such as serotonin, from the cytoplasm into the secretory vesicles. VAT2 is primarily expressed in the CNS and is involved in the ATP-dependent vesicular transport of biogenic amine neurotransmitters including dopamine, norepinephrine, serotonin, and histamine into synaptic vesicles. VATs belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340942 [Multi-domain]  Cd Length: 373  Bit Score: 43.33  E-value: 4.47e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124   3 LLAFVIISLS-SCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMptlRKWLLVFGNLITAGCY 81
Cdd:cd17384   197 LIAAGAICFSnSGIAILEPCLPIWMMETMCPPKWQLGTAFLPDSIGYLIGTNLFGPLAHKI---GRWLCSLLGMLLVGIS 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  82 MLLgpVPLLHIKSQLWLLVLVLvvnGISAGMSIIPTFPEMLSCAYANGfedsISTLGLVSGLFGAMWSVGAFMGPILGGF 161
Cdd:cd17384   274 LIL--IPLAKNIYGLIIPHFGL---GLGIGMVDSSMMPLLAYLVDLRH----SSVYGSVYAIADVAFCLAFALGPSLGGA 344


                  ....*....
gi 1302188124 162 LCEKIGFEW 170
Cdd:cd17384   345 IVKSIGFPW 353
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 2-184 1.05e-04

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 42.56  E-value: 1.05e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124   2 GLLAFVIISLSSCFGF--LDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSdKMPTLRKWLLVFGNLITAG 79
Cdd:cd17474   199 GLLTFLVSAFLYFFLYfaFLTYLPFLLELLYGISPIIIGLLFAGWSVLLALGSLFVGRLL-KKRFGARRILVIGLLLYAL 277

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  80 CYMLLGPVPllhiksQLWLLVLVLVVNGISAGMSIiPTFPEMLscayANGFEDSIstLGLVSGLFGAMWSVGAFMGPILG 159
Cdd:cd17474   278 SLLLLGFVP------SLALLLIAIVLFGLGLGLNL-PLLTTLV----TELAPEEE--RGTASSLYNFVRFLGQAVGPLLF 344

                         170       180
                  ....*....|....*....|....*
gi 1302188124 160 GFLCEKIGFEWAAAMQGLWTLLSGV 184
Cdd:cd17474   345 GLLLEIFGLSAPFLVGAAIALAAAV 369
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
3-190 1.68e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 41.79  E-value: 1.68e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124   3 LLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtLRKWLLVFGNLITAGCym 82
Cdd:COG2223   209 LLSLLYFGTFGSFIGFSSWLPPYLVDQFGLSAATAGLLAALFALLGALGRPLGGWLSDRIG-GRRVLLIVFALMALGL-- 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  83 llgpVPLLHIKSQLWLLVLVLVVNGISAGMSIIPTFPEMlscayanGFEDSISTLGLVSGLFGAMWSVGAFMGPILGGFL 162
Cdd:COG2223   286 ----LLLALALGSLWLFLVLFLLLGLALGGGNGAVFALV-------PDIFPTKNAGAVYGLVGAAGGLGGFLGPLLFGAL 354

                         170       180
                  ....*....|....*....|....*....
gi 1302188124 163 CEKIG-FEWAAAMQGLWTLLSGVSMALFY 190
Cdd:COG2223   355 LDATGsYTAAFLVFAVLALVALVLTLLLY 383
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
3-189 1.88e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 41.81  E-value: 1.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124   3 LLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVFGNLITAGCYM 82
Cdd:COG2211   232 LLLLAYLLFFLALALVAALLLYYFKYVLGLSAALVGLLLALYFLAALLGAPLWPRLAKRFG--KKKAFIIGLLLAALGLL 309

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  83 LLGPVPllhiKSQLWLLVLVLVVNGISAGMSIIPTFPEMLSCAYANGFEDSISTLGLVSGLFGAMWSVGAFMGPILGGFL 162
Cdd:COG2211   310 LLFFLG----PGNLWLLLVLAALAGIGLGAILVLPWAMLADVVDYDEWKTGRRREGLYFGIFTFAIKLGQALAGALAGLL 385

                         170       180       190
                  ....*....|....*....|....*....|..
gi 1302188124 163 CEKIGFEWAA-----AMQGLWTLLSGVSMALF 189
Cdd:COG2211   386 LALFGYVAGAaqspsALTGIRLLFFLLPAVLL 417
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
4-184 2.79e-04

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 41.01  E-value: 2.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124   4 LAFVIISLSSCFGFLD----PTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVFGNLITAG 79
Cdd:COG2271    10 RILALLFLAYFLNYLDrsnlSVAAPPLQADLGLSAAQLGLLASAFFLGYALGQIPAGLLADRFG--RRRVLAIGLLLWGL 87

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  80 CYMLLGPVPllhiksQLWLLVLVLVVNGISAGMsiiptfpEMLSCAYANGFEDSISTLGLVSGLFGAMWSVGAFMGPILG 159
Cdd:COG2271    88 ATLLFGFAT------SFWQLLLLRFLLGLGEAG-------FFPAALKLIAEWFPPKERGRALGIFNAGGPLGGALAPPLL 154

                         170       180
                  ....*....|....*....|....*
gi 1302188124 160 GFLCEKIGFEWAAAMQGLWTLLSGV 184
Cdd:COG2271   155 GWLLAAFGWRAAFLILGLPGLLLAL 179
MFS_YxlH_like cd17490
Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This ...
 2-190 2.81e-04

Bacillus subtilis YxlH and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Bacillus subtilis YxlH uncharacterized MFS-type transporter YxlH and similar proteins. The biological function of YxlH remains unclear. The YxlH-like subfamily belongs to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341043 [Multi-domain]  Cd Length: 371  Bit Score: 41.05  E-value: 2.81e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124   2 GLLAFV--IISLSSCFGFLDPTLSLFVMEKFSLstgyvGLVFLGLSLSYAISSPLFGLLSDKMPTLRKWLLvFGNLITAG 79
Cdd:cd17490   200 SLLAILqqMITFSTTFGFTPLIAKQLGASSFQL-----GLLSIIYLLPNALASLLSGTLFYKKLGERNTII-IGFLLLGA 273

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  80 CYMLlgpVPLLhikSQLWLLVLVLVVNGISAGMsiipTFPEMLSCAYANGFEDSISTlglVSGLFGAMWSVGAFMGPILG 159
Cdd:cd17490   274 YCFL---IPFA---PNLTLLYLLQALNGFGTGI----LFPLLMSLSIEGVPAEQRST---AMGFFQAIYALGMFLGPVLV 340

                         170       180       190
                  ....*....|....*....|....*....|.
gi 1302188124 160 GFLCEKIGFEWAAAMQGLWTLLSGVSMALFY 190
Cdd:cd17490   341 GIISEAFGLQTGFFVIGVIALLAAILSLAYY 371
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
3-192 3.08e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 40.99  E-value: 3.08e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124   3 LLAFVIISLSSCFGFLDPtLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVFGNLITAGCYM 82
Cdd:COG0738    12 AIYLLFFLWGFATALWGP-LIPALKDAFGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFG--YKRGLLLGLLLMALGLL 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  83 LLGPVPllhiksQLWLLVLVLVVNGISAGMSIIPTFPEMLSCAYANGfedsistlGLVSGLFGAMWSVGAFMGPILGGFL 162
Cdd:COG0738    89 LFALAP------SYPLLLLALFLLGLGLGLLDVAANPYVAALGPETA--------ASRLNLLHAFFSLGALLGPLLGGLL 154

                         170       180       190
                  ....*....|....*....|....*....|
gi 1302188124 163 cekIGFEWAAAMQGLWTLLSGVSMALFYLW 192
Cdd:COG0738   155 ---ILLGLSLSWHLPYLILAVLLLLLALLF 181
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 14-188 3.14e-04

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 41.06  E-value: 3.14e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  14 CFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVFGNLITAGCYMLLGpvpllhIK 93
Cdd:cd17329    14 GFFMVWPFMAIYLHQQLGLSASIVGLVLALSAVAGIVASLIGGRLADRFG--RKPVMLAGLLLRALGFALLG------FA 85

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  94 SQLWLLVLVLVVNGISAGMsIIPTFPEMLSCAYANGfedsisTLGLVSGLFGAMWSVGAFMGPILGGFLCEkIGFEWAAA 173
Cdd:cd17329    86 HSPWLFAIALVLTGFGGGL-FEPASEAMIADVTTPE------NRTRAFSLLYWAINLGVAIGPLLGGLLLL-YSFRLLFL 157

                         170
                  ....*....|....*
gi 1302188124 174 MQGLWTLLSGVSMAL 188
Cdd:cd17329   158 AAAVLFLLAALVLLF 172
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
15-192 8.56e-04

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 39.89  E-value: 8.56e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  15 FGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPTL---RKWLLVFGNLITAGCYMLLGPVPLLH 91
Cdd:COG2211    26 FGLLSAYLLYFYTDVLGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRwgrRRPWILIGAIPLALSFVLLFTAPDLS 105

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  92 IKSQLWLLVLVLVVNGISAGMSIIPTfpEMLSCAYANGFEDSIStlglVSGLFGAMWSVGAFMGPILGGFLCEKIGFEWA 171
Cdd:COG2211   106 PTGKLIYALVTYLLLGLAYTLVNIPY--SALGAELTPDYEERTR----LSSWRFAFAGLGGLLASVLPPPLVAAFGGDAA 179

                         170       180
                  ....*....|....*....|.
gi 1302188124 172 AAMQgLWTLLSGVSMALFYLW 192
Cdd:COG2211   180 LGYR-LTALIFAVLGLLAFLL 199
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 21-202 1.29e-03

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 39.14  E-value: 1.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  21 TLSLFVMEKFSlSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVFGNLITAGCyMLLGPVPLLHIKSQLWLLV 100
Cdd:cd06173    21 ALPWLVLQLTG-SALLVGLVLAAFFLPFLLFSPFAGVLADRFD--RRRLLILADLLRALL-AAVLALLALLGSLSLWLLL 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124 101 LVLVVNGISAGMSIIP---TFPEMLScayangfEDSISTLglvSGLFGAMWSVGAFMGPILGGFLCEKIGFEWAAAMQGL 177
Cdd:cd06173    97 VLAFLLGIASAFFGPArqaLLPELVP-------KEQLVRA---NALNSLATQLARIIGPALGGLLVALLGPGGAFAINAL 166

                         170       180
                  ....*....|....*....|....*
gi 1302188124 178 WTLLSGVSMALFYLWEDSTARRRSK 202
Cdd:cd06173   167 SFLLSALLLLFIRRPPPAAPGESSS 191
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
3-152 1.73e-03

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 38.80  E-value: 1.73e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124   3 LLAFVIISLSSCFGFLDPTLSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVFGNLITAGCYM 82
Cdd:COG2814   211 LLLLLAFLLGFGFFALFTYLPLYLQEVLGLSASAAGLLLALFGLGGVLGALLAGRLADRFG--RRRLLLIGLLLLALGLL 288

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  83 LLGPVPllhiksQLWLLVLVLVVNGISAGMSIIPTFPEMLSCAyangfedSISTLGLVSGLFGAMWSVGA 152
Cdd:COG2814   289 LLALAG------SLWLLLLALFLLGFGFGLLFPLLQALVAELA-------PPEARGRASGLYNSAFFLGG 345
MFS_Azr1_MDR_like cd17502
Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance ...
 138-170 4.47e-03

Saccharomyces cerevisiae Azole resistance protein 1 (Azr1p), and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of multidrug resistance (MDR) transporters including various Saccharomyces cerevisiae proteins such as azole resistance protein 1 (Azr1p), vacuolar basic amino acid transporter 1 (Vba1p), vacuolar basic amino acid transporter 5 (Vba5p), and Sge1p (also known as Nor1p, 10-N-nonyl acridine orange resistance protein, and crystal violet resistance protein). MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341045 [Multi-domain]  Cd Length: 337  Bit Score: 37.54  E-value: 4.47e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1302188124 138 GLVSGLFGAMWSVGAFMGPILGGFLCEKIGFEW 170
Cdd:cd17502   118 GKYQGYIGAVFGIASVAGPLIGGAFTDHLSWRW 150
MFS_GlpT cd17345
Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; ...
 25-112 4.72e-03

Glycerol-3-Phosphate Transporter of the Major Facilitator Superfamily of transporters; Glycerol-3-Phosphate Transporter (also called GlpT or G-3-P permease) is responsible for glycerol-3-phosphate uptake. It is part of the Organophosphate:Pi antiporter (OPA) family of integral membrane proteins responsible for the transport of specific organophosphates or sugar phosphates across biological membranes with the simultaneous translocation of inorganic phosphate into the opposite direction. The GlpT group belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340903 [Multi-domain]  Cd Length: 411  Bit Score: 37.61  E-value: 4.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  25 FVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPTlrKWLLVFGNLITAGCYMLLGPVPllHIKSQLWLLVLVLV 104
Cdd:cd17345    28 YLIEQYGLSKTEIGLIGSALSIAYGLSKFVMGNLSDRSNP--KRFLAIGLILSAIINILIGFVP--SATSSVGLMFILLF 103


                  ....*...
gi 1302188124 105 VNGISAGM 112
Cdd:cd17345   104 LNGWFQGM 111
MFS_LacY cd06172
LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY ...
 9-158 6.23e-03

LacY proton/sugar symporter family of the Major Facilitator Superfamily of transporters; LacY proton/sugar family (also called LacY/RafB family) symporters are integral membrane proteins responsible for the transport of specific beta-glucosides into the cell accompanied by the import of a proton. Members include lactose permease (LacY), raffinose permease (RafB), and sucrose permease, which facilitate the transport of beta-galactosides, raffinose, and sucrose, respectively. The prototypical member, LacY, contains 12 transmembrane helices connected by hydrophilic loops with both N and C termini on the cytoplasmic face. The LacY/RafB permease family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340862 [Multi-domain]  Cd Length: 389  Bit Score: 37.21  E-value: 6.23e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124   9 ISLSSCFGFLdptlSLFVMEKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMpTLRKWLLVFgnliTAGCYMLLGPV- 87
Cdd:cd06172    13 FIWSASFSFF----PIWLTQINHLSGSETGIVFSANSLFALLFQPVYGLISDKL-GLKKHLLWF----ISGLLVLFGPFf 83

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1302188124  88 -----PLLHIKSQLWLLVLVLVVN-GISAGMSIIPTFPEMLScaYANGFEDSISTLGlvsGLFGamWSVGAFMGPIL 158
Cdd:cd06172    84 ifvygPLLQSNILLGAIVGGIYLGfAFLAGCGAIESYIERVS--RRFNFEYGRARMW---GSLG--WALAAFFAGIL 153
MFS_spinster_like cd17328
Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; ...
 28-189 8.13e-03

Protein spinster and spinster homologs of the Major Facilitator Superfamily of transporters; The protein spinster family includes Drosophila protein spinster, its vertebrate homologs, and similar proteins. Humans contain three homologs called protein spinster homologs 1 (SPNS1), 2 (SPNS2), and 3 (SPNS3). Protein spinster and its homologs may be sphingolipid transporters that play central roles in endosomes and/or lysosomes storage. SPNS2 is also called sphingosine 1-phosphate (S1P) transporter and is required for migration of myocardial precursors. S1P is a secreted lipid mediator that plays critical roles in cardiovascular, immunological, and neural development and function. The spinster-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340886 [Multi-domain]  Cd Length: 405  Bit Score: 36.83  E-value: 8.13e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  28 EKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPtlRKWLLVFGNLITAGCYMLLGPVPllhiksQLWLLVLVLVVNG 107
Cdd:cd17328    27 SDFLIDDSLAGLLQTVFIISYMVLSPIFGYLGDRYN--RKWILAVGILIWSAATLLSSFAP------NFWQLLLFRALVG 98

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124 108 ISAGmSIIPTFPEMLSCAYANGfedsisTLGLVSGLFGAMWSVGAFMGPILGGFLCEKI-GFEWAAAMQGLWTLLSGVSM 186
Cdd:cd17328    99 IGEA-SYSPIAPTIIADLFPKE------KRTRALGVFYFAIPLGSGLGYVVGGLVAQATgGWRWAFRVTGVLGVLLAILL 171


                  ...
gi 1302188124 187 ALF 189
Cdd:cd17328   172 LLF 174
2A0104 TIGR00881
phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, ...
 28-112 8.71e-03

phosphoglycerate transporter family protein; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273319 [Multi-domain]  Cd Length: 379  Bit Score: 36.58  E-value: 8.71e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1302188124  28 EKFSLSTGYVGLVFLGLSLSYAISSPLFGLLSDKMPTlrKWLLVFGNLITAGCYMLLGPVPllhiksQLWLLVLVLVVNG 107
Cdd:TIGR00881  23 EEIGLSKTDLGLLLSSFSIAYGISKFVMGSVSDRSNP--RVFLPIGLILCAIVNLFFGFST------SLWVMAALWALNG 94


                  ....*
gi 1302188124 108 ISAGM 112
Cdd:TIGR00881  95 IFQGM 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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