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Conserved domains on  [gi|1337931647|ref|NP_001347291|]
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double zinc ribbon and ankyrin repeat-containing protein 1 isoform 3 [Mus musculus]

Protein Classification

ankyrin repeat domain-containing protein( domain architecture ID 12133965)

ankyrin (ANK) repeat domain-containing protein may be involved in mediating protein-protein interactions; ankyrin (ANK) repeat domain-containing protein may be involved in mediating protein-protein interactions; similar to Homo sapiens ankyrin repeat and SOCS box protein 7 isoform 1; ankyrin (ANK) repeat domain-containing protein may be involved in mediating protein-protein interactions; similar to Mus musculus ankyrin repeat domain-containing protein 61; ankyrin repeat (ANK) domain-containing protein may be involved in mediating protein-protein interactions; ankyrin repeat (ANK) domain-containing protein may be involved in mediating protein-protein interactions; ankyrin repeat (ANK) domain-containing protein may be involved in mediating protein-protein interactions; ankyrin repeat domain-containing protein similar to Homo sapiens NF-kappa-B inhibitor alpha that inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals; ankyrin repeat (ANK) domain-containing protein may be involved in mediating protein-protein interactions; ankyrin repeat domain-containing protein similar to Homo sapiens NF-kappa-B inhibitor alpha that inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals; ankyrin repeat domain-containing protein similar to human prostaglandin E receptor 4-associated protein (fem-1 homolog A), which interacts directly with NF-kappaB1 and attenuates macrophage activation; ankyrin repeat (ANK) domain-containing protein may be involved in mediating protein-protein interactions; ankyrin repeat (ANK) domain-containing protein may be involved in mediating protein-protein interactions; ankyrin repeat domain-containing protein similar to Homo sapiens NF-kappa-B inhibitor alpha that inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals; ankyrin repeat domain-containing protein similar to human prostaglandin E receptor 4-associated protein (fem-1 homolog A), which interacts directly with NF-kappaB1 and attenuates macrophage activation; ankyrin repeat (ANK) domain-containing protein may be involved in mediating protein-protein interactions; ankyrin repeat domain-containing protein similar to Homo sapiens NF-kappa-B inhibitor alpha that inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals; ankyrin repeat (ANK) domain-containing protein may be involved in mediating protein-protein interactions; ankyrin repeat domain-containing protein similar to Homo sapiens NF-kappa-B inhibitor alpha that inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals; ankyrin repeat domain-containing protein similar to human prostaglandin E receptor 4-associated protein (fem-1 homolog A), which interacts directly with NF-kappaB1 and attenuates macrophage activation; ankyrin repeat (ANK) domain-containing protein may be involved in mediating protein-protein interactions; ankyrin repeat domain-containing protein similar to Homo sapiens NF-kappa-B inhibitor alpha that inhibits the activity of dimeric NF-kappa-B/REL complexes by trapping REL dimers in the cytoplasm through masking of their nuclear localization signals; ankyrin repeat domain-containing protein similar to human prostaglandin E receptor 4-associated protein (fem-1 homolog A), which interacts directly with NF-kappaB1 and attenuates macrophage activation; ankyrin repeat (ANK) domain-containing protein may be involved in mediating protein-protein interactions; ankyrin repeat domain-containing protein similar to human prostaglandin E receptor 4-associated protein (fem-1 homolog A), which interacts directly with NF-kappaB1 and attenuates macrophage activation; ankyrin repeat (ANK) domain-containing protein may be involved in mediating protein-protein interactions; similar to Homo sapiens ankyrin repeat domain-containing protein 9

Gene Ontology:  GO:0005515
PubMed:  17176038

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fn3_assoc pfam13287
Fn3 associated;
32-100 8.38e-13

Fn3 associated;


:

Pssm-ID: 463829 [Multi-domain]  Cd Length: 59  Bit Score: 63.46  E-value: 8.38e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1337931647  32 LEMKSDTPDVNIYYTLDGSKPDflkkvgsgeNNTFKYVKPITLPDGKiQVKAVAVSKDCRQSGIVTKVF 100
Cdd:pfam13287   1 VTLTSETPGAEIYYTTDGSDPT---------TNSPKYTQPIVINENT-TIKAIAVRPGKNISKVVTETY 59
DZR pfam12773
Double zinc ribbon; This family consists of a pair of zinc ribbon domains.
 359-407 1.14e-11

Double zinc ribbon; This family consists of a pair of zinc ribbon domains.


:

Pssm-ID: 432773 [Multi-domain]  Cd Length: 45  Bit Score: 59.70  E-value: 1.14e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1337931647 359 CSRCGCQNLWEASFCDWCGAMLgisaSHSVCPKCGASNHLTARFCGSCG 407
Cdd:pfam12773   1 CPNCGHPNPPGAKFCPACGTPL----KPDRCPNCGAPVPPNARFCPYCG 45
DZR pfam12773
Double zinc ribbon; This family consists of a pair of zinc ribbon domains.
 230-289 3.92e-08

Double zinc ribbon; This family consists of a pair of zinc ribbon domains.


:

Pssm-ID: 432773 [Multi-domain]  Cd Length: 45  Bit Score: 49.68  E-value: 3.92e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337931647 230 CAHCLASRPSDpfARFCHECGAPVPPIFgyrlpppegaqmglCAECGSMVPMNTPICVVC 289
Cdd:pfam12773   1 CPNCGHPNPPG--AKFCPACGTPLKPDR--------------CPNCGAPVPPNARFCPYC 44
PRK14559 super family cl25535
serine/threonine phosphatase;
359-458 2.89e-03

serine/threonine phosphatase;


The actual alignment was detected with superfamily member PRK14559:

Pssm-ID: 237756 [Multi-domain]  Cd Length: 645  Bit Score: 40.81  E-value: 2.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337931647 359 CSRCGCQNLWEASFCDWCGAmlgiSASHSVCPKCGASNHLTARFCGSCGIYVKsiTRFRMHNSLAIVAGAPRPFPEPRSA 438
Cdd:PRK14559    4 CPQCQFENPNNNRFCQKCGT----SLTHKPCPQCGTEVPVDEAHCPNCGAETG--TIWWAIIAQASPNSEVLESGEATQQ 77

                          90       100
                  ....*....|....*....|
gi 1337931647 439 WQSLNVPLPTSASGSKKDTG 458
Cdd:PRK14559   78 SESSLTPSSSPLYGSYLDPG 97
 
Name Accession Description Interval E-value
Fn3_assoc pfam13287
Fn3 associated;
32-100 8.38e-13

Fn3 associated;


Pssm-ID: 463829 [Multi-domain]  Cd Length: 59  Bit Score: 63.46  E-value: 8.38e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1337931647  32 LEMKSDTPDVNIYYTLDGSKPDflkkvgsgeNNTFKYVKPITLPDGKiQVKAVAVSKDCRQSGIVTKVF 100
Cdd:pfam13287   1 VTLTSETPGAEIYYTTDGSDPT---------TNSPKYTQPIVINENT-TIKAIAVRPGKNISKVVTETY 59
DZR pfam12773
Double zinc ribbon; This family consists of a pair of zinc ribbon domains.
 359-407 1.14e-11

Double zinc ribbon; This family consists of a pair of zinc ribbon domains.


Pssm-ID: 432773 [Multi-domain]  Cd Length: 45  Bit Score: 59.70  E-value: 1.14e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1337931647 359 CSRCGCQNLWEASFCDWCGAMLgisaSHSVCPKCGASNHLTARFCGSCG 407
Cdd:pfam12773   1 CPNCGHPNPPGAKFCPACGTPL----KPDRCPNCGAPVPPNARFCPYCG 45
DZR pfam12773
Double zinc ribbon; This family consists of a pair of zinc ribbon domains.
 230-289 3.92e-08

Double zinc ribbon; This family consists of a pair of zinc ribbon domains.


Pssm-ID: 432773 [Multi-domain]  Cd Length: 45  Bit Score: 49.68  E-value: 3.92e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337931647 230 CAHCLASRPSDpfARFCHECGAPVPPIFgyrlpppegaqmglCAECGSMVPMNTPICVVC 289
Cdd:pfam12773   1 CPNCGHPNPPG--AKFCPACGTPLKPDR--------------CPNCGAPVPPNARFCPYC 44
PRK14559 PRK14559
serine/threonine phosphatase;
359-458 2.89e-03

serine/threonine phosphatase;


Pssm-ID: 237756 [Multi-domain]  Cd Length: 645  Bit Score: 40.81  E-value: 2.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337931647 359 CSRCGCQNLWEASFCDWCGAmlgiSASHSVCPKCGASNHLTARFCGSCGIYVKsiTRFRMHNSLAIVAGAPRPFPEPRSA 438
Cdd:PRK14559    4 CPQCQFENPNNNRFCQKCGT----SLTHKPCPQCGTEVPVDEAHCPNCGAETG--TIWWAIIAQASPNSEVLESGEATQQ 77

                          90       100
                  ....*....|....*....|
gi 1337931647 439 WQSLNVPLPTSASGSKKDTG 458
Cdd:PRK14559   78 SESSLTPSSSPLYGSYLDPG 97
 
Name Accession Description Interval E-value
Fn3_assoc pfam13287
Fn3 associated;
32-100 8.38e-13

Fn3 associated;


Pssm-ID: 463829 [Multi-domain]  Cd Length: 59  Bit Score: 63.46  E-value: 8.38e-13
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1337931647  32 LEMKSDTPDVNIYYTLDGSKPDflkkvgsgeNNTFKYVKPITLPDGKiQVKAVAVSKDCRQSGIVTKVF 100
Cdd:pfam13287   1 VTLTSETPGAEIYYTTDGSDPT---------TNSPKYTQPIVINENT-TIKAIAVRPGKNISKVVTETY 59
DZR pfam12773
Double zinc ribbon; This family consists of a pair of zinc ribbon domains.
 359-407 1.14e-11

Double zinc ribbon; This family consists of a pair of zinc ribbon domains.


Pssm-ID: 432773 [Multi-domain]  Cd Length: 45  Bit Score: 59.70  E-value: 1.14e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1337931647 359 CSRCGCQNLWEASFCDWCGAMLgisaSHSVCPKCGASNHLTARFCGSCG 407
Cdd:pfam12773   1 CPNCGHPNPPGAKFCPACGTPL----KPDRCPNCGAPVPPNARFCPYCG 45
DZR pfam12773
Double zinc ribbon; This family consists of a pair of zinc ribbon domains.
 230-289 3.92e-08

Double zinc ribbon; This family consists of a pair of zinc ribbon domains.


Pssm-ID: 432773 [Multi-domain]  Cd Length: 45  Bit Score: 49.68  E-value: 3.92e-08
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337931647 230 CAHCLASRPSDpfARFCHECGAPVPPIFgyrlpppegaqmglCAECGSMVPMNTPICVVC 289
Cdd:pfam12773   1 CPNCGHPNPPG--AKFCPACGTPLKPDR--------------CPNCGAPVPPNARFCPYC 44
CHB_HEX_C_1 pfam13290
Chitobiase/beta-hexosaminidase C-terminal domain;
27-97 4.64e-08

Chitobiase/beta-hexosaminidase C-terminal domain;


Pssm-ID: 433091 [Multi-domain]  Cd Length: 67  Bit Score: 50.36  E-value: 4.64e-08
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1337931647  27 DTNTLLEMKSDTPDVNIYYTLDGSKPDFlkkvgsgenNTFKYVKPITLPDGKiQVKAVAVSKDCRQSGIVT 97
Cdd:pfam13290   7 SSAQTVTLSTATEGATIYYTTDGSEPTT---------SSPKYTGPITISSTT-TIKAIAVDDGGNSSAVVT 67
PRK14559 PRK14559
serine/threonine phosphatase;
359-458 2.89e-03

serine/threonine phosphatase;


Pssm-ID: 237756 [Multi-domain]  Cd Length: 645  Bit Score: 40.81  E-value: 2.89e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1337931647 359 CSRCGCQNLWEASFCDWCGAmlgiSASHSVCPKCGASNHLTARFCGSCGIYVKsiTRFRMHNSLAIVAGAPRPFPEPRSA 438
Cdd:PRK14559    4 CPQCQFENPNNNRFCQKCGT----SLTHKPCPQCGTEVPVDEAHCPNCGAETG--TIWWAIIAQASPNSEVLESGEATQQ 77

                          90       100
                  ....*....|....*....|
gi 1337931647 439 WQSLNVPLPTSASGSKKDTG 458
Cdd:PRK14559   78 SESSLTPSSSPLYGSYLDPG 97
DZR pfam12773
Double zinc ribbon; This family consists of a pair of zinc ribbon domains.
 389-414 5.07e-03

Double zinc ribbon; This family consists of a pair of zinc ribbon domains.


Pssm-ID: 432773 [Multi-domain]  Cd Length: 45  Bit Score: 35.43  E-value: 5.07e-03
                          10        20
                  ....*....|....*....|....*.
gi 1337931647 389 CPKCGASNHLTARFCGSCGIYVKSIT 414
Cdd:pfam12773   1 CPNCGHPNPPGAKFCPACGTPLKPDR 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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