NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1375023059|ref|NP_001349065|]
View 

MICOS complex subunit Mic60 isoform 8 [Mus musculus]

Protein Classification

MICOS complex subunit MIC60( domain architecture ID 12101363)

MICOS complex subunit MIC60 is a component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 43-733 0e+00

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


:

Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 572.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  43 AGKIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPlpkKPVQSGPLKISSVSEVMKDSK 122
Cdd:pfam09731   4 FGKFFVALVLIVGVGYGGVVLYAYKDDNFRDFFEEYIPYGEEVVLYALGEDPPLAP---KPKTFRPLQPSVVSAVTGESK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 123 LPVAQSQKTKGDTPASagdtlsvpapavQHEDTIKTECPNTNEGKSTSetteeafsssvrerppeevaarlAQQEKQEQV 202
Cdd:pfam09731  81 EPKEEKKQVKIPRQSG------------VSSEVAEEEKEATKDAAEAK-----------------------AQLPKSEQE 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 203 EMESLAKSLEDALNRTSSVTLQTITAQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALKErrkavdeaadal 282
Cdd:pfam09731 126 KEKALEEVLKEAISKAESATAVAKEAKDDAIQAVKAHTDSLKEASDTAEISREKATDSALQKAEALAE------------ 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 283 lkakeeleKMKTIIEDAKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFRKELDS 362
Cdd:pfam09731 194 --------KLKEVINLAKQSEEEAAPPLLDAAPETPPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVASERIVFQQELVS 265

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 363 ITPDITPGWKGMSisdlagKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEKHKlEEKRTFDSAVAKALEH 442
Cdd:pfam09731 266 IFPDIIPVLKEDN------LLSNDDLNSLIAHAHREIDQLSKKLAELKKREEKHIERALEKQK-EELDKLAEELSARLEE 338

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 443 HRS----EIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSEQElefrrrsqeq 518
Cdd:pfam09731 339 VRAadeaQLRLEFEREREEIRESYEEKLRTELERQAEAHEEHLKDVLVEQEIELQREFLQDIKEKVEEER---------- 408

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 519 mDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAEMPTIPLGSAVEAIRVNCSDNEFTQA 598
Cdd:pfam09731 409 -AGRLLKLNELLANLKGLEKATSSHSEVEDENRKAQQLWLAVEALRSTLEDGSADSRPRPLVRELKALKELASDDEVVKA 487

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 599 LTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPKQlkppAELYPEDINTFKLL 678
Cdd:pfam09731 488 ALASLPEEAYQRGVYTEAALRERFRRVAKEVRKVSLIDPEGAGLLSHALSYLLSKLMFKPKQ----GEADPAGDDVESIL 563

                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1375023059 679 SYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKEARMTLETKQIVEILTAYAS 733
Cdd:pfam09731 564 ARAEYYLEEGDLDSAAREMNSLKGWSKKLASDWLKEARRRLEVQQALELLQAEAA 618
 
Name Accession Description Interval E-value
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 43-733 0e+00

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 572.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  43 AGKIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPlpkKPVQSGPLKISSVSEVMKDSK 122
Cdd:pfam09731   4 FGKFFVALVLIVGVGYGGVVLYAYKDDNFRDFFEEYIPYGEEVVLYALGEDPPLAP---KPKTFRPLQPSVVSAVTGESK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 123 LPVAQSQKTKGDTPASagdtlsvpapavQHEDTIKTECPNTNEGKSTSetteeafsssvrerppeevaarlAQQEKQEQV 202
Cdd:pfam09731  81 EPKEEKKQVKIPRQSG------------VSSEVAEEEKEATKDAAEAK-----------------------AQLPKSEQE 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 203 EMESLAKSLEDALNRTSSVTLQTITAQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALKErrkavdeaadal 282
Cdd:pfam09731 126 KEKALEEVLKEAISKAESATAVAKEAKDDAIQAVKAHTDSLKEASDTAEISREKATDSALQKAEALAE------------ 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 283 lkakeeleKMKTIIEDAKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFRKELDS 362
Cdd:pfam09731 194 --------KLKEVINLAKQSEEEAAPPLLDAAPETPPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVASERIVFQQELVS 265

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 363 ITPDITPGWKGMSisdlagKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEKHKlEEKRTFDSAVAKALEH 442
Cdd:pfam09731 266 IFPDIIPVLKEDN------LLSNDDLNSLIAHAHREIDQLSKKLAELKKREEKHIERALEKQK-EELDKLAEELSARLEE 338

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 443 HRS----EIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSEQElefrrrsqeq 518
Cdd:pfam09731 339 VRAadeaQLRLEFEREREEIRESYEEKLRTELERQAEAHEEHLKDVLVEQEIELQREFLQDIKEKVEEER---------- 408

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 519 mDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAEMPTIPLGSAVEAIRVNCSDNEFTQA 598
Cdd:pfam09731 409 -AGRLLKLNELLANLKGLEKATSSHSEVEDENRKAQQLWLAVEALRSTLEDGSADSRPRPLVRELKALKELASDDEVVKA 487

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 599 LTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPKQlkppAELYPEDINTFKLL 678
Cdd:pfam09731 488 ALASLPEEAYQRGVYTEAALRERFRRVAKEVRKVSLIDPEGAGLLSHALSYLLSKLMFKPKQ----GEADPAGDDVESIL 563

                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1375023059 679 SYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKEARMTLETKQIVEILTAYAS 733
Cdd:pfam09731 564 ARAEYYLEEGDLDSAAREMNSLKGWSKKLASDWLKEARRRLEVQQALELLQAEAA 618
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 259-556 7.14e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.02  E-value: 7.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 259 AQWRTVEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKReiagatphITAAEGRLHNMIVDLDNVVKKVQAAQSE 338
Cdd:COG1196   232 LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE--------LEELELELEEAQAEEYELLAELARLEQD 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 339 AKVVSQYHELVVQARDDFRKELDSITpditpgwkgMSISDLAGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIE 418
Cdd:COG1196   304 IARLEERRRELEERLEELEEELAELE---------EELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAEL 374

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 419 LALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQ 498
Cdd:COG1196   375 AEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAEL 454

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1375023059 499 GLSEKLSEQELEFRRRS----QEQMDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 556
Cdd:COG1196   455 EEEEEALLELLAELLEEaallEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLL 516
PTZ00121 PTZ00121
MAEBL; Provisional
 147-556 7.51e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 49.75  E-value: 7.51e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  147 APAVQHEDTIKTECPNTNEGKSTSETTEEAFSSSVRERPPEEVAARLAQQEKQEQvemESLAKSLEDALNRTSSVTLQTI 226
Cdd:PTZ00121  1298 AEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEA---EAAADEAEAAEEKAEAAEKKKE 1374

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  227 TAQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQwrTVEGALKERRKAvDEA---ADALLKAKEelekMKTIIEDAKKRE 303
Cdd:PTZ00121  1375 EAKKKADAAKKKAEEKKKADEAKKKAEEDKKKAD--ELKKAAAAKKKA-DEAkkkAEEKKKADE----AKKKAEEAKKAD 1447

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  304 IAGAtphiTAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQArDDFRKELDSITPDITPGWKGMSISDLAGKL 383
Cdd:PTZ00121  1448 EAKK----KAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKA-EEAKKKADEAKKAAEAKKKADEAKKAEEAK 1522

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  384 STDDLNSliAHAHRRIDQLNRELAQQKATE---KQHIELALEKHKLEEKRTFD---------SAVAKALEHHRSE----- 446
Cdd:PTZ00121  1523 KADEAKK--AEEAKKADEAKKAEEKKKADElkkAEELKKAEEKKKAEEAKKAEedknmalrkAEEAKKAEEARIEevmkl 1600

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  447 ------IQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGL--SEKLSEQELEFRRRSQEQ 518
Cdd:PTZ00121  1601 yeeekkMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKikAAEEAKKAEEDKKKAEEA 1680

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|.
gi 1375023059  519 MDSFTLDINTAYARLRGIEQAVQSHAV---AEEEARKAHQL 556
Cdd:PTZ00121  1681 KKAEEDEKKAAEALKKEAEEAKKAEELkkkEAEEKKKAEEL 1721
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 208-542 2.39e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.13  E-value: 2.39e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  208 AKSLEDALN-------RTSSVTLQ--TITAQNAAVQA-VKAHSNILKTamdNSEIagEKKSAQWRTVEGALKERRKAVDE 277
Cdd:TIGR02168  628 VDDLDNALElakklrpGYRIVTLDgdLVRPGGVITGGsAKTNSSILER---RREI--EELEEKIEELEEKIAELEKALAE 702

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  278 AADALLKAKEELEKMKTIIEDaKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFR 357
Cdd:TIGR02168  703 LRKELEELEEELEQLRKELEE-LSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAE 781

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  358 KELDSITPDITPGWKGMSISDLAGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEK-----------HKL 426
Cdd:TIGR02168  782 AEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIeelsedieslaAEI 861

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  427 EEKRTFDSAVAKALEHHrSEIQAEQDRKVEEVRDAMENEM---------RTQLRRQAAAHTDHLRDvLKVQEQELKYEFE 497
Cdd:TIGR02168  862 EELEELIEELESELEAL-LNERASLEEALALLRSELEELSeelreleskRSELRRELEELREKLAQ-LELRLEGLEVRID 939

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 1375023059  498 QgLSEKLSEQ---ELEFrrrSQEQMDSFTLDINTAYARLRGIEQAVQS 542
Cdd:TIGR02168  940 N-LQERLSEEyslTLEE---AEALENKIEDDEEEARRRLKRLENKIKE 983
 
Name Accession Description Interval E-value
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 43-733 0e+00

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 572.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  43 AGKIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPlpkKPVQSGPLKISSVSEVMKDSK 122
Cdd:pfam09731   4 FGKFFVALVLIVGVGYGGVVLYAYKDDNFRDFFEEYIPYGEEVVLYALGEDPPLAP---KPKTFRPLQPSVVSAVTGESK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 123 LPVAQSQKTKGDTPASagdtlsvpapavQHEDTIKTECPNTNEGKSTSetteeafsssvrerppeevaarlAQQEKQEQV 202
Cdd:pfam09731  81 EPKEEKKQVKIPRQSG------------VSSEVAEEEKEATKDAAEAK-----------------------AQLPKSEQE 125

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 203 EMESLAKSLEDALNRTSSVTLQTITAQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALKErrkavdeaadal 282
Cdd:pfam09731 126 KEKALEEVLKEAISKAESATAVAKEAKDDAIQAVKAHTDSLKEASDTAEISREKATDSALQKAEALAE------------ 193

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 283 lkakeeleKMKTIIEDAKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFRKELDS 362
Cdd:pfam09731 194 --------KLKEVINLAKQSEEEAAPPLLDAAPETPPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVASERIVFQQELVS 265

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 363 ITPDITPGWKGMSisdlagKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEKHKlEEKRTFDSAVAKALEH 442
Cdd:pfam09731 266 IFPDIIPVLKEDN------LLSNDDLNSLIAHAHREIDQLSKKLAELKKREEKHIERALEKQK-EELDKLAEELSARLEE 338

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 443 HRS----EIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSEQElefrrrsqeq 518
Cdd:pfam09731 339 VRAadeaQLRLEFEREREEIRESYEEKLRTELERQAEAHEEHLKDVLVEQEIELQREFLQDIKEKVEEER---------- 408

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 519 mDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAEMPTIPLGSAVEAIRVNCSDNEFTQA 598
Cdd:pfam09731 409 -AGRLLKLNELLANLKGLEKATSSHSEVEDENRKAQQLWLAVEALRSTLEDGSADSRPRPLVRELKALKELASDDEVVKA 487

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 599 LTAAIPPESLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPKQlkppAELYPEDINTFKLL 678
Cdd:pfam09731 488 ALASLPEEAYQRGVYTEAALRERFRRVAKEVRKVSLIDPEGAGLLSHALSYLLSKLMFKPKQ----GEADPAGDDVESIL 563

                         650       660       670       680       690
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1375023059 679 SYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKEARMTLETKQIVEILTAYAS 733
Cdd:pfam09731 564 ARAEYYLEEGDLDSAAREMNSLKGWSKKLASDWLKEARRRLEVQQALELLQAEAA 618
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 259-556 7.14e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.02  E-value: 7.14e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 259 AQWRTVEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKReiagatphITAAEGRLHNMIVDLDNVVKKVQAAQSE 338
Cdd:COG1196   232 LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE--------LEELELELEEAQAEEYELLAELARLEQD 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 339 AKVVSQYHELVVQARDDFRKELDSITpditpgwkgMSISDLAGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIE 418
Cdd:COG1196   304 IARLEERRRELEERLEELEEELAELE---------EELEELEEELEELEEELEEAEEELEEAEAELAEAEEALLEAEAEL 374

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 419 LALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQ 498
Cdd:COG1196   375 AEAEEELEELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEELEELEEALAELEEEEEEEEEALEEAAEEEAEL 454

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1375023059 499 GLSEKLSEQELEFRRRS----QEQMDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQL 556
Cdd:COG1196   455 EEEEEALLELLAELLEEaallEAALAELLEELAEAAARLLLLLEAEADYEGFLEGVKAALLL 516
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
259-487 3.17e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 50.68  E-value: 3.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  259 AQWRTVEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKR----EIAGATPHITAAEGRLHNmiVDLDNVVKKVQA 334
Cdd:COG4913    692 EQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRleaaEDLARLELRALLEERFAA--ALGDAVERELRE 769

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  335 ------AQSEAKVVSQYHELV--------------------VQARDDFRKELDSITPDITPG-----------WKGMSIS 377
Cdd:COG4913    770 nleeriDALRARLNRAEEELEramrafnrewpaetadldadLESLPEYLALLDRLEEDGLPEyeerfkellneNSIEFVA 849

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  378 DLAGKLSTDdlnslIAHAHRRIDQLNRELAQQKATEKQHIELALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEE 457
Cdd:COG4913    850 DLLSKLRRA-----IREIKERIDPLNDSLKRIPFGPGRYLRLEARPRPDPEVREFRQELRAVTSGASLFDEELSEARFAA 924

                          250       260       270
                   ....*....|....*....|....*....|.
gi 1375023059  458 VRDAMEnemrtQLRRQAAAHTDH-LRDVLKV 487
Cdd:COG4913    925 LKRLIE-----RLRSEEEESDRRwRARVLDV 950
PTZ00121 PTZ00121
MAEBL; Provisional
 147-556 7.51e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 49.75  E-value: 7.51e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  147 APAVQHEDTIKTECPNTNEGKSTSETTEEAFSSSVRERPPEEVAARLAQQEKQEQvemESLAKSLEDALNRTSSVTLQTI 226
Cdd:PTZ00121  1298 AEEKKKADEAKKKAEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEA---EAAADEAEAAEEKAEAAEKKKE 1374

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  227 TAQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQwrTVEGALKERRKAvDEA---ADALLKAKEelekMKTIIEDAKKRE 303
Cdd:PTZ00121  1375 EAKKKADAAKKKAEEKKKADEAKKKAEEDKKKAD--ELKKAAAAKKKA-DEAkkkAEEKKKADE----AKKKAEEAKKAD 1447

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  304 IAGAtphiTAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQArDDFRKELDSITPDITPGWKGMSISDLAGKL 383
Cdd:PTZ00121  1448 EAKK----KAEEAKKAEEAKKKAEEAKKADEAKKKAEEAKKADEAKKKA-EEAKKKADEAKKAAEAKKKADEAKKAEEAK 1522

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  384 STDDLNSliAHAHRRIDQLNRELAQQKATE---KQHIELALEKHKLEEKRTFD---------SAVAKALEHHRSE----- 446
Cdd:PTZ00121  1523 KADEAKK--AEEAKKADEAKKAEEKKKADElkkAEELKKAEEKKKAEEAKKAEedknmalrkAEEAKKAEEARIEevmkl 1600

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  447 ------IQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGL--SEKLSEQELEFRRRSQEQ 518
Cdd:PTZ00121  1601 yeeekkMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEELKKAEEENKikAAEEAKKAEEDKKKAEEA 1680

                          410       420       430       440
                   ....*....|....*....|....*....|....*....|.
gi 1375023059  519 MDSFTLDINTAYARLRGIEQAVQSHAV---AEEEARKAHQL 556
Cdd:PTZ00121  1681 KKAEEDEKKAAEALKKEAEEAKKAEELkkkEAEEKKKAEEL 1721
PTZ00121 PTZ00121
MAEBL; Provisional
 126-556 9.53e-06

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 49.37  E-value: 9.53e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  126 AQSQKTKGDTPASAGDTLSVPAPAVQHEDTIKTECPNTNEGKSTSETTEEAfsssvreRPPEEVAARLAQQEKQEQVEME 205
Cdd:PTZ00121  1393 ADEAKKKAEEDKKKADELKKAAAAKKKADEAKKKAEEKKKADEAKKKAEEA-------KKADEAKKKAEEAKKAEEAKKK 1465

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  206 SLAKSLEDALNRTSSVTLQTITAQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALK-ERRKAVDEAADALLK 284
Cdd:PTZ00121  1466 AEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKADEAKKAEEAKKADEAKKaEEAKKADEAKKAEEK 1545

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  285 AK-EELEKMktiiEDAKKREIAGATPHITAAEGRlHNMIVDLDNVVKKVQAAQSEaKVVSQYHELVVQARDDFRKEldsi 363
Cdd:PTZ00121  1546 KKaDELKKA----EELKKAEEKKKAEEAKKAEED-KNMALRKAEEAKKAEEARIE-EVMKLYEEEKKMKAEEAKKA---- 1615

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  364 tpditpgwkgmsisdlagklstddlnsliAHAHRRIDQLNRELAQQKATEKQHIELALEKHKLEE--KRTFDSAVAKALE 441
Cdd:PTZ00121  1616 -----------------------------EEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEElkKAEEENKIKAAEE 1666

                          330       340       350       360       370       380       390       400
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  442 HHRSEiqaEQDRKVEEVRDAMENEMrtqlrrqaaahtdhlrdvlKVQEQELKYEFEQGLSEKLSEQELEFRRRSQEQMDS 521
Cdd:PTZ00121  1667 AKKAE---EDKKKAEEAKKAEEDEK-------------------KAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKA 1724

                          410       420       430
                   ....*....|....*....|....*....|....*
gi 1375023059  522 ftldintAYARLRGIEQAVQShavAEEEARKAHQL 556
Cdd:PTZ00121  1725 -------EEENKIKAEEAKKE---AEEDKKKAEEA 1749
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 208-542 2.39e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 48.13  E-value: 2.39e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  208 AKSLEDALN-------RTSSVTLQ--TITAQNAAVQA-VKAHSNILKTamdNSEIagEKKSAQWRTVEGALKERRKAVDE 277
Cdd:TIGR02168  628 VDDLDNALElakklrpGYRIVTLDgdLVRPGGVITGGsAKTNSSILER---RREI--EELEEKIEELEEKIAELEKALAE 702

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  278 AADALLKAKEELEKMKTIIEDaKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFR 357
Cdd:TIGR02168  703 LRKELEELEEELEQLRKELEE-LSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEELAEAE 781

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  358 KELDSITPDITPGWKGMSISDLAGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEK-----------HKL 426
Cdd:TIGR02168  782 AEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIeelsedieslaAEI 861

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  427 EEKRTFDSAVAKALEHHrSEIQAEQDRKVEEVRDAMENEM---------RTQLRRQAAAHTDHLRDvLKVQEQELKYEFE 497
Cdd:TIGR02168  862 EELEELIEELESELEAL-LNERASLEEALALLRSELEELSeelreleskRSELRRELEELREKLAQ-LELRLEGLEVRID 939

                          330       340       350       360
                   ....*....|....*....|....*....|....*....|....*...
gi 1375023059  498 QgLSEKLSEQ---ELEFrrrSQEQMDSFTLDINTAYARLRGIEQAVQS 542
Cdd:TIGR02168  940 N-LQERLSEEyslTLEE---AEALENKIEDDEEEARRRLKRLENKIKE 983
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 187-507 3.93e-05

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 47.14  E-value: 3.93e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  187 EEVAARLAQQEKQEQ----VEMESLAKSLEDALN---RTSSVTLQTITAQnaAVQAVKAHSNILKTAMDNSEIAGEKKSA 259
Cdd:pfam12128  641 ETFARTALKNARLDLrrlfDEKQSEKDKKNKALAerkDSANERLNSLEAQ--LKQLDKKHQAWLEEQKEQKREARTEKQA 718

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  260 QWRTVEGALKERRKAVDEAADAL-LKAKEELEKMKTiiedAKKREIAGATPHitaaEGRLHNMIVDLDNVVKKV-QAAQS 337
Cdd:pfam12128  719 YWQVVEGALDAQLALLKAAIAARrSGAKAELKALET----WYKRDLASLGVD----PDVIAKLKREIRTLERKIeRIAVR 790

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  338 EAKVVSQ---YHELVVQARDDFRKELDSITpditpgwkgMSISDLagklsTDDLNSLIAHAHRRIDQLNRELaqqKATEK 414
Cdd:pfam12128  791 RQEVLRYfdwYQETWLQRRPRLATQLSNIE---------RAISEL-----QQQLARLIADTKLRRAKLEMER---KASEK 853

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  415 QHIELALEKHKLeekRTFDSAVAKALEHHRSE----IQAEQDRKVEEVRDAMENEMrtqlrRQAAAHTDHLRDVLKVQEQ 490
Cdd:pfam12128  854 QQVRLSENLRGL---RCEMSKLATLKEDANSEqaqgSIGERLAQLEDLKLKRDYLS-----ESVKKYVEHFKNVIADHSG 925

                          330
                   ....*....|....*..
gi 1375023059  491 ELKYEFEQGLSEKLSEQ 507
Cdd:pfam12128  926 SGLAETWESLREEDHYQ 942
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 187-510 7.01e-05

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 46.47  E-value: 7.01e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 187 EEVAARLAQQEKQEQVEMESLAKSLEDALNRTSSVTLQTITAQNAAVQAVKAHsNILKTAMDNSEIAGE-----KKSAQW 261
Cdd:COG1196   441 EEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARL-LLLLEAEADYEGFLEgvkaaLLLAGL 519

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 262 RTVEGAL-------KERRKAVDEAADALLKAK--EELEKMKTIIEDAKKREIAGAT--PHITAAEGRLHNMIVDLDNVVK 330
Cdd:COG1196   520 RGLAGAVavligveAAYEAALEAALAAALQNIvvEDDEVAAAAIEYLKAAKAGRATflPLDKIRARAALAAALARGAIGA 599

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 331 KVQAAQSEAkvvsQYHELVVQARDDFRKELDSITPDITPGWKGMSISDLAGKLSTDDLNSLIAHAHRRIDQLNRELAQQK 410
Cdd:COG1196   600 AVDLVASDL----READARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALL 675

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 411 ATEKQHIELALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEvrdamENEMRTQLRRQAAAHTDHLRDVLKVQEQ 490
Cdd:COG1196   676 EAEAELEELAERLAEEELELEEALLAEEEEERELAEAEEERLEEELE-----EEALEEQLEAEREELLEELLEEEELLEE 750

                         330       340
                  ....*....|....*....|
gi 1375023059 491 ELKYEFEQGLSEKLSEQELE 510
Cdd:COG1196   751 EALEELPEPPDLEELERELE 770
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
267-532 1.07e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 45.68  E-value: 1.07e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  267 ALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKREIAgatpHITAAE--------GRLHNMIVDLDNVVKKVQAAQSE 338
Cdd:COG4913    611 KLAALEAELAELEEELAEAEERLEALEAELDALQERREA----LQRLAEyswdeidvASAEREIAELEAELERLDASSDD 686

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  339 AKVVSQYHELVVQARDDFRKELDSItpditpgwkgmsiSDLAGKLSTDdlnslIAHAHRRIDQLNRELAQQKATEKQHIE 418
Cdd:COG4913    687 LAALEEQLEELEAELEELEEELDEL-------------KGEIGRLEKE-----LEQAEEELDELQDRLEAAEDLARLELR 748

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  419 LALEKHKLEE-KRTFDSAVAKALEHHRSEIQAEQDRKveevRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFE 497
Cdd:COG4913    749 ALLEERFAAAlGDAVERELRENLEERIDALRARLNRA----EEELERAMRAFNREWPAETADLDADLESLPEYLALLDRL 824

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 1375023059  498 QglSEKLSEQELEFRRRSQEQMDSFTLDINTAYAR 532
Cdd:COG4913    825 E--EDGLPEYEERFKELLNENSIEFVADLLSKLRR 857
ARGLU pfam15346
Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is ...
 436-555 1.40e-04

Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.


Pssm-ID: 405931 [Multi-domain]  Cd Length: 151  Bit Score: 42.73  E-value: 1.40e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 436 VAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAhtdhlrdvlKVQEQELKYEFEQGLSEKLSEQELEFRRRS 515
Cdd:pfam15346  24 VEEELEKRKDEIEAEVERRVEEARKIMEKQVLEELEREREA---------ELEEERRKEEEERKKREELERILEENNRKI 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1375023059 516 QEQMDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQ 555
Cdd:pfam15346  95 EEAQRKEAEERLAMLEEQRRMKEERQRREKEEEEREKREQ 134
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 386-554 5.45e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 43.52  E-value: 5.45e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  386 DDLNSLIAHAHRRIDQLNREL--AQQKATEKQ-HIELALEKH-----KLEEKRTFDSAVAKALEHHRSEIQ------AEQ 451
Cdd:TIGR02169  691 SSLQSELRRIENRLDELSQELsdASRKIGEIEkEIEQLEQEEeklkeRLEELEEDLSSLEQEIENVKSELKeleariEEL 770

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  452 DRKVEEVRDAMEN-----------EMRTQLRRQAAAHTDhLRDVLKVQEQEL-KYEFEQGLSEKLSEQELEFRRRSQEQM 519
Cdd:TIGR02169  771 EEDLHKLEEALNDlearlshsripEIQAELSKLEEEVSR-IEARLREIEQKLnRLTLEKEYLEKEIQELQEQRIDLKEQI 849

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1375023059  520 DSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 554
Cdd:TIGR02169  850 KSIEKEIENLNGKKEELEEELEELEAALRDLESRL 884
COG4223 COG4223
Uncharacterized conserved protein [Function unknown];
500-734 1.19e-03

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443367 [Multi-domain]  Cd Length: 259  Bit Score: 41.57  E-value: 1.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 500 LSEKLSEQELEFRRRSQEQMDsftLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSaemptiPL 579
Cdd:COG4223    39 LEARLAALRAALAAAREAVAA---AAAAALEARLAALEAKAAAPEAEAAAAARAAALALAAAALRAAVERGQ------PF 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 580 GSAVEAIRVNCSDNEFTQALTAAippesLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLlfppk 659
Cdd:COG4223   110 AAELAALEALAPDAPALAALAAF-----AATGVPTLAALRAEFPAAARAALAAARAPEADASWLDRLLAFARSLV----- 179

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1375023059 660 QLKPPAElyPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKEARMTLETKQIVEILTAYASA 734
Cdd:COG4223   180 TVRRVGP--VEGDDPDAILARAEAALAAGDLAGALAELEALPEAAQAAAAPWIAKAEARLAADAALQALAAQALA 252
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
393-536 1.32e-03

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.21  E-value: 1.32e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  393 AHAHRRIDQLNRELAQQKATEKQHIELALEKHKLEEkrtfDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMR----- 467
Cdd:COG4913    647 REALQRLAEYSWDEIDVASAEREIAELEAELERLDA----SSDDLAALEEQLEELEAELEELEEELDELKGEIGRlekel 722

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  468 TQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSE-KLSEQELEFRRRSQEQMDSFTLDINTAYARLRGI 536
Cdd:COG4913    723 EQAEEELDELQDRLEAAEDLARLELRALLEERFAAaLGDAVERELRENLEERIDALRARLNRAEEELERA 792
PTZ00121 PTZ00121
MAEBL; Provisional
 397-573 1.44e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 42.44  E-value: 1.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  397 RRIDQLNR-ELAQQKATEKQHIElalEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQaa 475
Cdd:PTZ00121  1224 KKAEAVKKaEEAKKDAEEAKKAE---EERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKA-- 1298

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  476 ahtdhlRDVLKVQEQELKYEfEQGLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARlRGIEQAVQSHAVAEEEARKAHQ 555
Cdd:PTZ00121  1299 ------EEKKKADEAKKKAE-EAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAA-KAEAEAAADEAEAAEEKAEAAE 1370

                          170
                   ....*....|....*...
gi 1375023059  556 LWLSVEALKYSMKTSSAE 573
Cdd:PTZ00121  1371 KKKEEAKKKADAAKKKAE 1388
PRK02224 PRK02224
DNA double-strand break repair Rad50 ATPase;
154-542 1.97e-03

DNA double-strand break repair Rad50 ATPase;


Pssm-ID: 179385 [Multi-domain]  Cd Length: 880  Bit Score: 41.56  E-value: 1.97e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 154 DTIKTECPNTNEGKSTSETTEEAFSSSVRERPP------EEVAARLAQQEKqEQVEMESLAKSLEDALNRTSSVTlQTIT 227
Cdd:PRK02224  254 ETLEAEIEDLRETIAETEREREELAEEVRDLRErleeleEERDDLLAEAGL-DDADAEAVEARREELEDRDEELR-DRLE 331

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 228 AQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEgalkerrKAVDEAADALLKAKEELEKMKTIIEDAKKR----- 302
Cdd:PRK02224  332 ECRVAAQAHNEEAESLREDADDLEERAEELREEAAELE-------SELEEAREAVEDRREEIEELEEEIEELRERfgdap 404

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 303 -EIAGATPH---ITAAEGRLHNMIVDL-------DNVVKKVQAAQSEAK---------------VVSQYHELVVQ---AR 353
Cdd:PRK02224  405 vDLGNAEDFleeLREERDELREREAELeatlrtaRERVEEAEALLEAGKcpecgqpvegsphveTIEEDRERVEEleaEL 484

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 354 DDFRKELDSITPDITPGWKGMSISDLAGKLST--DDLNSLIAHAHRRIDQlNRELAQQKATEKQHIELALEKHKLEEKRT 431
Cdd:PRK02224  485 EDLEEEVEEVEERLERAEDLVEAEDRIERLEErrEDLEELIAERRETIEE-KRERAEELRERAAELEAEAEEKREAAAEA 563

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 432 FDSA-----VAKALEHHRSEIQAEQDR--KVEEVRDAMEN-----EMRTQLRRQAAAHTDHLRDVLKVqeqelKYEFEQG 499
Cdd:PRK02224  564 EEEAeeareEVAELNSKLAELKERIESleRIRTLLAAIADaedeiERLREKREALAELNDERRERLAE-----KRERKRE 638

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|...
gi 1375023059 500 LSEKLSEQELEFRRRSQEQMDSFTLDINTAYARLRGIEQAVQS 542
Cdd:PRK02224  639 LEAEFDEARIEEAREDKERAEEYLEQVEEKLDELREERDDLQA 681
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 404-553 3.37e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.08  E-value: 3.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 404 RELaQQKATEKQHIELALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRdamenEMRTQLRRQAAAHTDHLRD 483
Cdd:COG1196   216 REL-KEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELE-----ELRLELEELELELEEAQAE 289

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 484 VLKVQEQELKYEFEQGLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKA 553
Cdd:COG1196   290 EYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAE 359
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 405-577 3.69e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.88  E-value: 3.69e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 405 ELAQQKATEKQHIELALEKHKLEEKRtfdsavaKALEHHRSeiQAEQDRKVEEVRDAMENEMRTqlRRQAAAHTDHLRDV 484
Cdd:pfam17380 449 ERVRLEEQERQQQVERLRQQEEERKR-------KKLELEKE--KRDRKRAEEQRRKILEKELEE--RKQAMIEEERKRKL 517

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 485 LKVQEQELK---YEFEQ---GLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARLRgiEQAVQSHAVAEEEARKAHQLWL 558
Cdd:pfam17380 518 LEKEMEERQkaiYEEERrreAEEERRKQQEMEERRRIQEQMRKATEERSRLEAMER--EREMMRQIVESEKARAEYEATT 595

                         170       180
                  ....*....|....*....|.
gi 1375023059 559 SVEALK--YSMKTSSAEMPTI 577
Cdd:pfam17380 596 PITTIKpiYRPRISEYQPPDV 616
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 278-515 4.06e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.13  E-value: 4.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 278 AADALLKAKEELEKMKTIIEdAKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFR 357
Cdd:COG4942    18 QADAAAEAEAELEQLQQEIA-ELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELR 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 358 KELDSITPDITP----GWKGMSISDLAGKLSTDDLNSLIAHAhRRIDQLNRELAQQ-KATEKQHIELALEKHKLEEKRTF 432
Cdd:COG4942    97 AELEAQKEELAEllraLYRLGRQPPLALLLSPEDFLDAVRRL-QYLKYLAPARREQaEELRADLAELAALRAELEAERAE 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 433 DSAVAKALEHHRSEIQAEQDRKveevrdameNEMRTQLRRQAAAHTDHLRDvLKVQEQELkyefeQGLSEKLSEQELEFR 512
Cdd:COG4942   176 LEALLAELEEERAALEALKAER---------QKLLARLEKELAELAAELAE-LQQEAEEL-----EALIARLEAEAAAAA 240


                  ...
gi 1375023059 513 RRS 515
Cdd:COG4942   241 ERT 243
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 400-518 5.44e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 40.34  E-value: 5.44e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059  400 DQLNRELAQQKATEKQHIELALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHtd 479
Cdd:TIGR00618  256 LKKQQLLKQLRARIEELRAQEAVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAH-- 333

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1375023059  480 hlrdvlkvQEQELKYEFEQGLSEKLSEQELEFRRRSQEQ 518
Cdd:TIGR00618  334 --------VKQQSSIEEQRRLLQTLHSQEIHIRDAHEVA 364
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 187-556 7.20e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 39.92  E-value: 7.20e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 187 EEVAARLAQQEKQEQVEMESLAKSLEDALnrtssvtlQTITAQNAAVQAVKAHSNILKtamdnSEIAGEKKSAQwrtveg 266
Cdd:COG1196   245 EAELEELEAELEELEAELAELEAELEELR--------LELEELELELEEAQAEEYELL-----AELARLEQDIA------ 305

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 267 ALKERRKAVDEAADALLKAKEELEKmktiiedakkreiagatpHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYH 346
Cdd:COG1196   306 RLEERRRELEERLEELEEELAELEE------------------ELEELEEELEELEEELEEAEEELEEAEAELAEAEEAL 367

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 347 ELVVQARDDFRKELDsitpditpgwkgmsisdlagklstDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEKHKL 426
Cdd:COG1196   368 LEAEAELAEAEEELE------------------------ELAEELLEALRAAAELAAQLEELEEAEEALLERLERLEEEL 423

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023059 427 EEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSE 506
Cdd:COG1196   424 EELEEALAELEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALAELLEELAEAAARLLLLLEAEADY 503

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|
gi 1375023059 507 QELEFRRRSQEQMDSFTLdINTAYARLRGIEQAVQSHAVAEEEARKAHQL 556
Cdd:COG1196   504 EGFLEGVKAALLLAGLRG-LAGAVAVLIGVEAAYEAALEAALAAALQNIV 552
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH