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Conserved domains on  [gi|1375023219|ref|NP_001349066|]
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MICOS complex subunit Mic60 isoform 9 [Mus musculus]

Protein Classification

MICOS complex subunit MIC60( domain architecture ID 12101363)

MICOS complex subunit MIC60 is a component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 43-713 0e+00

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


:

Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 585.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  43 AGKIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPlpkKPVQSGPLKISSVSEVMKDSK 122
Cdd:pfam09731   4 FGKFFVALVLIVGVGYGGVVLYAYKDDNFRDFFEEYIPYGEEVVLYALGEDPPLAP---KPKTFRPLQPSVVSAVTGESK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 123 LPVAQSQKTKGDTPASAASTGAaqiisaagdtlSVPAPAVQHEDTIKTECPNTNEGKSTsettALAKSLEDALNRTSSVT 202
Cdd:pfam09731  81 EPKEEKKQVKIPRQSGVSSEVA-----------EEEKEATKDAAEAKAQLPKSEQEKEK----ALEEVLKEAISKAESAT 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 203 LQTITAQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALKErrkavdeaadallkakeeleKMKTIIEDAKKR 282
Cdd:pfam09731 146 AVAKEAKDDAIQAVKAHTDSLKEASDTAEISREKATDSALQKAEALAE--------------------KLKEVINLAKQS 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 283 EIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITPGWKGMSisdlagK 362
Cdd:pfam09731 206 EEEAAPPLLDAAPETPPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVASERIVFQQELVSIFPDIIPVLKEDN------L 279

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 363 LSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEKHKlEEKRTFDSAVAKALEHHRS----EIQAEQDRKVEEV 438
Cdd:pfam09731 280 LSNDDLNSLIAHAHREIDQLSKKLAELKKREEKHIERALEKQK-EELDKLAEELSARLEEVRAadeaQLRLEFEREREEI 358

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 439 RDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSEQElefrrrsqeqmDSFTLDINTAYARLRGIEQ 518
Cdd:pfam09731 359 RESYEEKLRTELERQAEAHEEHLKDVLVEQEIELQREFLQDIKEKVEEER-----------AGRLLKLNELLANLKGLEK 427

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 519 AVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAEMPTIPLGSAVEAIRVNCSDNEFTQALTAAIPPESLTRGVYSEETL 598
Cdd:pfam09731 428 ATSSHSEVEDENRKAQQLWLAVEALRSTLEDGSADSRPRPLVRELKALKELASDDEVVKAALASLPEEAYQRGVYTEAAL 507

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 599 RARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPKQlkppAELYPEDINTFKLLSYASYCIEHGDLELAAKFVN 678
Cdd:pfam09731 508 RERFRRVAKEVRKVSLIDPEGAGLLSHALSYLLSKLMFKPKQ----GEADPAGDDVESILARAEYYLEEGDLDSAAREMN 583

                         650       660       670
                  ....*....|....*....|....*....|....*
gi 1375023219 679 QLKGESRRVAQDWLKEARMTLETKQIVEILTAYAS 713
Cdd:pfam09731 584 SLKGWSKKLASDWLKEARRRLEVQQALELLQAEAA 618
 
Name Accession Description Interval E-value
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 43-713 0e+00

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 585.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  43 AGKIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPlpkKPVQSGPLKISSVSEVMKDSK 122
Cdd:pfam09731   4 FGKFFVALVLIVGVGYGGVVLYAYKDDNFRDFFEEYIPYGEEVVLYALGEDPPLAP---KPKTFRPLQPSVVSAVTGESK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 123 LPVAQSQKTKGDTPASAASTGAaqiisaagdtlSVPAPAVQHEDTIKTECPNTNEGKSTsettALAKSLEDALNRTSSVT 202
Cdd:pfam09731  81 EPKEEKKQVKIPRQSGVSSEVA-----------EEEKEATKDAAEAKAQLPKSEQEKEK----ALEEVLKEAISKAESAT 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 203 LQTITAQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALKErrkavdeaadallkakeeleKMKTIIEDAKKR 282
Cdd:pfam09731 146 AVAKEAKDDAIQAVKAHTDSLKEASDTAEISREKATDSALQKAEALAE--------------------KLKEVINLAKQS 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 283 EIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITPGWKGMSisdlagK 362
Cdd:pfam09731 206 EEEAAPPLLDAAPETPPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVASERIVFQQELVSIFPDIIPVLKEDN------L 279

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 363 LSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEKHKlEEKRTFDSAVAKALEHHRS----EIQAEQDRKVEEV 438
Cdd:pfam09731 280 LSNDDLNSLIAHAHREIDQLSKKLAELKKREEKHIERALEKQK-EELDKLAEELSARLEEVRAadeaQLRLEFEREREEI 358

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 439 RDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSEQElefrrrsqeqmDSFTLDINTAYARLRGIEQ 518
Cdd:pfam09731 359 RESYEEKLRTELERQAEAHEEHLKDVLVEQEIELQREFLQDIKEKVEEER-----------AGRLLKLNELLANLKGLEK 427

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 519 AVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAEMPTIPLGSAVEAIRVNCSDNEFTQALTAAIPPESLTRGVYSEETL 598
Cdd:pfam09731 428 ATSSHSEVEDENRKAQQLWLAVEALRSTLEDGSADSRPRPLVRELKALKELASDDEVVKAALASLPEEAYQRGVYTEAAL 507

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 599 RARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPKQlkppAELYPEDINTFKLLSYASYCIEHGDLELAAKFVN 678
Cdd:pfam09731 508 RERFRRVAKEVRKVSLIDPEGAGLLSHALSYLLSKLMFKPKQ----GEADPAGDDVESILARAEYYLEEGDLDSAAREMN 583

                         650       660       670
                  ....*....|....*....|....*....|....*
gi 1375023219 679 QLKGESRRVAQDWLKEARMTLETKQIVEILTAYAS 713
Cdd:pfam09731 584 SLKGWSKKLASDWLKEARRRLEVQQALELLQAEAA 618
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 239-544 3.25e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.79  E-value: 3.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 239 AQWRTVEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKReiagatphITAAEGRLHNMIVDLDNVVKKVQAAQSE 318
Cdd:COG1196   232 LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE--------LEELELELEEAQAEEYELLAELARLEQD 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 319 akvvsqyHELVVQARDDFRKELDSItpditpgwkgmsisdlagklsTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIE 398
Cdd:COG1196   304 -------IARLEERRRELEERLEEL---------------------EEELAELEEELEELEEELEELEEELEEAEEELEE 355

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 399 LALEKHKLEEKRtfdSAVAKALEHHRSEIQAEQDRKVEEVRDAME-----NEMRTQLRRQAAAHTDHLRDVLKVQEQELK 473
Cdd:COG1196   356 AEAELAEAEEAL---LEAEAELAEAEEELEELAEELLEALRAAAElaaqlEELEEAEEALLERLERLEEELEELEEALAE 432

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1375023219 474 YEFEQGLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARLRGIEQAVQshAVAEEEARKAHQLWLSVEALK 544
Cdd:COG1196   433 LEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALA--ELLEELAEAAARLLLLLEAEA 501
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 184-522 4.53e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.44  E-value: 4.53e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  184 TTALAKSLEDALN-------RTSSVTLQ--TITAQNAAVQA-VKAHSNILKTamdNSEIagEKKSAQWRTVEGALKERRK 253
Cdd:TIGR02168  624 GVLVVDDLDNALElakklrpGYRIVTLDgdLVRPGGVITGGsAKTNSSILER---RREI--EELEEKIEELEEKIAELEK 698

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  254 AVDEAADALLKAKEELEKMKTIIEDaKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQAR 333
Cdd:TIGR02168  699 ALAELRKELEELEEELEQLRKELEE-LSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEEL 777

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  334 DDFRKELDSITPDITPGWKGMSISDLAGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEK---------- 403
Cdd:TIGR02168  778 AEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIeelsediesl 857

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  404 -HKLEEKRTFDSAVAKALEHHrSEIQAEQDRKVEEVRDAMENEM---------RTQLRRQAAAHTDHLRDvLKVQEQELK 473
Cdd:TIGR02168  858 aAEIEELEELIEELESELEAL-LNERASLEEALALLRSELEELSeelreleskRSELRRELEELREKLAQ-LELRLEGLE 935

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1375023219  474 YEFEQgLSEKLSEQ---ELEFrrrSQEQMDSFTLDINTAYARLRGIEQAVQS 522
Cdd:TIGR02168  936 VRIDN-LQERLSEEyslTLEE---AEALENKIEDDEEEARRRLKRLENKIKE 983
PTZ00121 PTZ00121
MAEBL; Provisional
 208-536 2.73e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.75  E-value: 2.73e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  208 AQNAAVQAVKAHsNILKTAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEK---MKTIIEDAKKREI 284
Cdd:PTZ00121  1449 AKKKAEEAKKAE-EAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKadeAKKAEEAKKADEA 1527

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  285 AGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSE-AKVVSQYHELVVQARDDFRKELDSITPDITPGWKGMSISDLAGKL 363
Cdd:PTZ00121  1528 KKAEEAKKADEAKKAEEKKKADELKKAEELKKAEeKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKM 1607

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  364 STDDLNSLiAHAHRRIDQLNRELAQQKATEKQHIELALEKHKLEE--KRTFDSAVAKALEHHRSEiqaEQDRKVEEVRDA 441
Cdd:PTZ00121  1608 KAEEAKKA-EEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEElkKAEEENKIKAAEEAKKAE---EDKKKAEEAKKA 1683

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  442 MENEMrtqlrrqaaahtdhlrdvlKVQEQELKYEFEQGLSEKLSEQELEFRRRSQEQMDSftldintAYARLRGIEQAVQ 521
Cdd:PTZ00121  1684 EEDEK-------------------KAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKA-------EEENKIKAEEAKK 1737

                          330
                   ....*....|....*
gi 1375023219  522 ShavAEEEARKAHQL 536
Cdd:PTZ00121  1738 E---AEEDKKKAEEA 1749
 
Name Accession Description Interval E-value
Mitofilin pfam09731
Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. ...
 43-713 0e+00

Mitochondrial inner membrane protein; Mitofilin controls mitochondrial cristae morphology. Mitofilin is enriched in the narrow space between the inner boundary and the outer membranes, where it forms a homotypic interaction and assembles into a large multimeric protein complex. The first 78 amino acids contain a typical amino-terminal-cleavable mitochondrial presequence rich in positive-charged and hydroxylated residues and a membrane anchor domain. In addition, it has three centrally located coiled coil domains.


Pssm-ID: 430783 [Multi-domain]  Cd Length: 618  Bit Score: 585.18  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  43 AGKIAGAGLLFVGGGIGGTILYAKWDSHFRESVEKTIPYSDKLFGMVLGSAPYTVPlpkKPVQSGPLKISSVSEVMKDSK 122
Cdd:pfam09731   4 FGKFFVALVLIVGVGYGGVVLYAYKDDNFRDFFEEYIPYGEEVVLYALGEDPPLAP---KPKTFRPLQPSVVSAVTGESK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 123 LPVAQSQKTKGDTPASAASTGAaqiisaagdtlSVPAPAVQHEDTIKTECPNTNEGKSTsettALAKSLEDALNRTSSVT 202
Cdd:pfam09731  81 EPKEEKKQVKIPRQSGVSSEVA-----------EEEKEATKDAAEAKAQLPKSEQEKEK----ALEEVLKEAISKAESAT 145

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 203 LQTITAQNAAVQAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALKErrkavdeaadallkakeeleKMKTIIEDAKKR 282
Cdd:pfam09731 146 AVAKEAKDDAIQAVKAHTDSLKEASDTAEISREKATDSALQKAEALAE--------------------KLKEVINLAKQS 205

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 283 EIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITPGWKGMSisdlagK 362
Cdd:pfam09731 206 EEEAAPPLLDAAPETPPKLPEHLDNVEEKVEKAQSLAKLVDQYKELVASERIVFQQELVSIFPDIIPVLKEDN------L 279

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 363 LSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEKHKlEEKRTFDSAVAKALEHHRS----EIQAEQDRKVEEV 438
Cdd:pfam09731 280 LSNDDLNSLIAHAHREIDQLSKKLAELKKREEKHIERALEKQK-EELDKLAEELSARLEEVRAadeaQLRLEFEREREEI 358

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 439 RDAMENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSEQElefrrrsqeqmDSFTLDINTAYARLRGIEQ 518
Cdd:pfam09731 359 RESYEEKLRTELERQAEAHEEHLKDVLVEQEIELQREFLQDIKEKVEEER-----------AGRLLKLNELLANLKGLEK 427

                         490       500       510       520       530       540       550       560
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 519 AVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSAEMPTIPLGSAVEAIRVNCSDNEFTQALTAAIPPESLTRGVYSEETL 598
Cdd:pfam09731 428 ATSSHSEVEDENRKAQQLWLAVEALRSTLEDGSADSRPRPLVRELKALKELASDDEVVKAALASLPEEAYQRGVYTEAAL 507

                         570       580       590       600       610       620       630       640
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 599 RARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLLFPPKQlkppAELYPEDINTFKLLSYASYCIEHGDLELAAKFVN 678
Cdd:pfam09731 508 RERFRRVAKEVRKVSLIDPEGAGLLSHALSYLLSKLMFKPKQ----GEADPAGDDVESILARAEYYLEEGDLDSAAREMN 583

                         650       660       670
                  ....*....|....*....|....*....|....*
gi 1375023219 679 QLKGESRRVAQDWLKEARMTLETKQIVEILTAYAS 713
Cdd:pfam09731 584 SLKGWSKKLASDWLKEARRRLEVQQALELLQAEAA 618
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 239-544 3.25e-07

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 53.79  E-value: 3.25e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 239 AQWRTVEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKReiagatphITAAEGRLHNMIVDLDNVVKKVQAAQSE 318
Cdd:COG1196   232 LKLRELEAELEELEAELEELEAELEELEAELAELEAELEELRLE--------LEELELELEEAQAEEYELLAELARLEQD 303

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 319 akvvsqyHELVVQARDDFRKELDSItpditpgwkgmsisdlagklsTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIE 398
Cdd:COG1196   304 -------IARLEERRRELEERLEEL---------------------EEELAELEEELEELEEELEELEEELEEAEEELEE 355

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 399 LALEKHKLEEKRtfdSAVAKALEHHRSEIQAEQDRKVEEVRDAME-----NEMRTQLRRQAAAHTDHLRDVLKVQEQELK 473
Cdd:COG1196   356 AEAELAEAEEAL---LEAEAELAEAEEELEELAEELLEALRAAAElaaqlEELEEAEEALLERLERLEEELEELEEALAE 432

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1375023219 474 YEFEQGLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARLRGIEQAVQshAVAEEEARKAHQLWLSVEALK 544
Cdd:COG1196   433 LEEEEEEEEEALEEAAEEEAELEEEEEALLELLAELLEEAALLEAALA--ELLEELAEAAARLLLLLEAEA 501
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
239-467 1.75e-06

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 51.45  E-value: 1.75e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  239 AQWRTVEGALKERRKAVDEAADALLKAKEELEKMKTIIEDAKKR----EIAGATPHITAAEGRLHNmiVDLDNVVKKVQA 314
Cdd:COG4913    692 EQLEELEAELEELEEELDELKGEIGRLEKELEQAEEELDELQDRleaaEDLARLELRALLEERFAA--ALGDAVERELRE 769

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  315 A------QSEAKVVSQYHELV--------------------VQARDDFRKELDSITPDITPG-----------WKGMSIS 357
Cdd:COG4913    770 NleeridALRARLNRAEEELEramrafnrewpaetadldadLESLPEYLALLDRLEEDGLPEyeerfkellneNSIEFVA 849

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  358 DLAGKLSTDdlnslIAHAHRRIDQLNRELAQQKATEKQHIELALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEE 437
Cdd:COG4913    850 DLLSKLRRA-----IREIKERIDPLNDSLKRIPFGPGRYLRLEARPRPDPEVREFRQELRAVTSGASLFDEELSEARFAA 924

                          250       260       270
                   ....*....|....*....|....*....|.
gi 1375023219  438 VRDAMEnemrtQLRRQAAAHTDH-LRDVLKV 467
Cdd:COG4913    925 LKRLIE-----RLRSEEEESDRRwRARVLDV 950
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 184-522 4.53e-06

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 50.44  E-value: 4.53e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  184 TTALAKSLEDALN-------RTSSVTLQ--TITAQNAAVQA-VKAHSNILKTamdNSEIagEKKSAQWRTVEGALKERRK 253
Cdd:TIGR02168  624 GVLVVDDLDNALElakklrpGYRIVTLDgdLVRPGGVITGGsAKTNSSILER---RREI--EELEEKIEELEEKIAELEK 698

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  254 AVDEAADALLKAKEELEKMKTIIEDaKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQAR 333
Cdd:TIGR02168  699 ALAELRKELEELEEELEQLRKELEE-LSRQISALRKDLARLEAEVEQLEERIAQLSKELTELEAEIEELEERLEEAEEEL 777

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  334 DDFRKELDSITPDITPGWKGMSISDLAGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEK---------- 403
Cdd:TIGR02168  778 AEAEAEIEELEAQIEQLKEELKALREALDELRAELTLLNEEAANLRERLESLERRIAATERRLEDLEEQIeelsediesl 857

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  404 -HKLEEKRTFDSAVAKALEHHrSEIQAEQDRKVEEVRDAMENEM---------RTQLRRQAAAHTDHLRDvLKVQEQELK 473
Cdd:TIGR02168  858 aAEIEELEELIEELESELEAL-LNERASLEEALALLRSELEELSeelreleskRSELRRELEELREKLAQ-LELRLEGLE 935

                          330       340       350       360       370
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1375023219  474 YEFEQgLSEKLSEQ---ELEFrrrSQEQMDSFTLDINTAYARLRGIEQAVQS 522
Cdd:TIGR02168  936 VRIDN-LQERLSEEyslTLEE---AEALENKIEDDEEEARRRLKRLENKIKE 983
ARGLU pfam15346
Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is ...
 416-535 2.26e-05

Arginine and glutamate-rich 1; ARGLU, arginine and glutamate-rich 1 protein family, is required for the oestrogen-dependent expression of ESR1 target genes. It functions in cooperation with MED1. The family of proteins is found in eukaryotes.


Pssm-ID: 405931 [Multi-domain]  Cd Length: 151  Bit Score: 45.04  E-value: 2.26e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 416 VAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAhtdhlrdvlKVQEQELKYEFEQGLSEKLSEQELEFRRRS 495
Cdd:pfam15346  24 VEEELEKRKDEIEAEVERRVEEARKIMEKQVLEELEREREA---------ELEEERRKEEEERKKREELERILEENNRKI 94

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 1375023219 496 QEQMDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAHQ 535
Cdd:pfam15346  95 EEAQRKEAEERLAMLEEQRRMKEERQRREKEEEEREKREQ 134
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 366-534 1.88e-04

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 45.06  E-value: 1.88e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  366 DDLNSLIAHAHRRIDQLNREL--AQQKATEKQ-HIELALEKH-----KLEEKRTFDSAVAKALEHHRSEIQ------AEQ 431
Cdd:TIGR02169  691 SSLQSELRRIENRLDELSQELsdASRKIGEIEkEIEQLEQEEeklkeRLEELEEDLSSLEQEIENVKSELKeleariEEL 770

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  432 DRKVEEVRDAMEN-----------EMRTQLRRQAAAHTDhLRDVLKVQEQEL-KYEFEQGLSEKLSEQELEFRRRSQEQM 499
Cdd:TIGR02169  771 EEDLHKLEEALNDlearlshsripEIQAELSKLEEEVSR-IEARLREIEQKLnRLTLEKEYLEKEIQELQEQRIDLKEQI 849

                          170       180       190
                   ....*....|....*....|....*....|....*
gi 1375023219  500 DSFTLDINTAYARLRGIEQAVQSHAVAEEEARKAH 534
Cdd:TIGR02169  850 KSIEKEIENLNGKKEELEEELEELEAALRDLESRL 884
PTZ00121 PTZ00121
MAEBL; Provisional
 208-536 2.73e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 44.75  E-value: 2.73e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  208 AQNAAVQAVKAHsNILKTAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADALLKAKEELEK---MKTIIEDAKKREI 284
Cdd:PTZ00121  1449 AKKKAEEAKKAE-EAKKKAEEAKKADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKadeAKKAEEAKKADEA 1527

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  285 AGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSE-AKVVSQYHELVVQARDDFRKELDSITPDITPGWKGMSISDLAGKL 363
Cdd:PTZ00121  1528 KKAEEAKKADEAKKAEEKKKADELKKAEELKKAEeKKKAEEAKKAEEDKNMALRKAEEAKKAEEARIEEVMKLYEEEKKM 1607

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  364 STDDLNSLiAHAHRRIDQLNRELAQQKATEKQHIELALEKHKLEE--KRTFDSAVAKALEHHRSEiqaEQDRKVEEVRDA 441
Cdd:PTZ00121  1608 KAEEAKKA-EEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKAEElkKAEEENKIKAAEEAKKAE---EDKKKAEEAKKA 1683

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  442 MENEMrtqlrrqaaahtdhlrdvlKVQEQELKYEFEQGLSEKLSEQELEFRRRSQEQMDSftldintAYARLRGIEQAVQ 521
Cdd:PTZ00121  1684 EEDEK-------------------KAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKA-------EEENKIKAEEAKK 1737

                          330
                   ....*....|....*
gi 1375023219  522 ShavAEEEARKAHQL 536
Cdd:PTZ00121  1738 E---AEEDKKKAEEA 1749
DUF3584 pfam12128
Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. ...
 182-487 3.37e-04

Protein of unknown function (DUF3584); This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 943 to 1234 amino acids in length. This family contains a P-loop motif suggesting it is a nucleotide binding protein. It may be involved in replication.


Pssm-ID: 432349 [Multi-domain]  Cd Length: 1191  Bit Score: 44.06  E-value: 3.37e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  182 SETTALAKSLEDAlNRTSSVTLQTITAQnaAVQAVKAHSNILKTAMDNSEIAGEKKSAQWRTVEGALKERRKAVDEAADA 261
Cdd:pfam12128  664 SEKDKKNKALAER-KDSANERLNSLEAQ--LKQLDKKHQAWLEEQKEQKREARTEKQAYWQVVEGALDAQLALLKAAIAA 740

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  262 L-LKAKEELEKMKTiiedAKKREIAGATPHitaaEGRLHNMIVDLDNVVKKV-QAAQSEAKVVSQ---YHELVVQARDDF 336
Cdd:pfam12128  741 RrSGAKAELKALET----WYKRDLASLGVD----PDVIAKLKREIRTLERKIeRIAVRRQEVLRYfdwYQETWLQRRPRL 812

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  337 RKELDSITpditpgwkgMSISDLagklsTDDLNSLIAHAHRRIDQLNRELaqqKATEKQHIELALEKHKLeekRTFDSAV 416
Cdd:pfam12128  813 ATQLSNIE---------RAISEL-----QQQLARLIADTKLRRAKLEMER---KASEKQQVRLSENLRGL---RCEMSKL 872

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1375023219  417 AKALEHHRSE----IQAEQDRKVEEVRDAMENEMrtqlrRQAAAHTDHLRDVLKVQEQELKYEFEQGLSEKLSEQ 487
Cdd:pfam12128  873 ATLKEDANSEqaqgSIGERLAQLEDLKLKRDYLS-----ESVKKYVEHFKNVIADHSGSGLAETWESLREEDHYQ 942
PTZ00121 PTZ00121
MAEBL; Provisional
 377-553 5.39e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.59  E-value: 5.39e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  377 RRIDQLNR-ELAQQKATEKQHIElalEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQaa 455
Cdd:PTZ00121  1224 KKAEAVKKaEEAKKDAEEAKKAE---EERNNEEIRKFEEARMAHFARRQAAIKAEEARKADELKKAEEKKKADEAKKA-- 1298

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  456 ahtdhlRDVLKVQEQELKYEfEQGLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARlRGIEQAVQSHAVAEEEARKAHQ 535
Cdd:PTZ00121  1299 ------EEKKKADEAKKKAE-EAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAA-KAEAEAAADEAEAAEEKAEAAE 1370

                          170
                   ....*....|....*...
gi 1375023219  536 LWLSVEALKYSMKTSSAE 553
Cdd:PTZ00121  1371 KKKEEAKKKADAAKKKAE 1388
PTZ00121 PTZ00121
MAEBL; Provisional
 223-536 7.00e-04

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 43.21  E-value: 7.00e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  223 LKTAMDNSEIAGEKKSAQWRTVEGALK--ERRKAVDEAADALLKAKEELEKMKTIIEDAKKREIAGATPHITAAegrlhn 300
Cdd:PTZ00121  1283 LKKAEEKKKADEAKKAEEKKKADEAKKkaEEAKKADEAKKKAEEAKKKADAAKKKAEEAKKAAEAAKAEAEAAA------ 1356

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  301 mivdldnvvKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSitpditpgwkgmsisdlagKLSTDDLNSLIAHAHRRID 380
Cdd:PTZ00121  1357 ---------DEAEAAEEKAEAAEKKKEEAKKKADAAKKKAEE-------------------KKKADEAKKKAEEDKKKAD 1408

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  381 QLNRELAQQKATEKQhielaleKHKLEEKRTFDSAVAKAlehhrseiqaEQDRKVEEVRDAMENEMRTQLRRQAAAHTDH 460
Cdd:PTZ00121  1409 ELKKAAAAKKKADEA-------KKKAEEKKKADEAKKKA----------EEAKKADEAKKKAEEAKKAEEAKKKAEEAKK 1471

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1375023219  461 LRDVLKVQEQELKYEFEQGLSEKLSEQELEFRRRSQEQMDSftldintayARLRGIEQAVQS-HAVAEEEARKAHQL 536
Cdd:PTZ00121  1472 ADEAKKKAEEAKKADEAKKKAEEAKKKADEAKKAAEAKKKA---------DEAKKAEEAKKAdEAKKAEEAKKADEA 1539
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 385-557 8.79e-04

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 42.80  E-value: 8.79e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 385 ELAQQKATEKQHIELALEKHKLEEKRtfdsavaKALEHHRSeiQAEQDRKVEEVRDAMENEMRTqlRRQAAAHTDHLRDV 464
Cdd:pfam17380 449 ERVRLEEQERQQQVERLRQQEEERKR-------KKLELEKE--KRDRKRAEEQRRKILEKELEE--RKQAMIEEERKRKL 517

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 465 LKVQEQELK---YEFEQ---GLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARLRgiEQAVQSHAVAEEEARKAHQLWL 538
Cdd:pfam17380 518 LEKEMEERQkaiYEEERrreAEEERRKQQEMEERRRIQEQMRKATEERSRLEAMER--EREMMRQIVESEKARAEYEATT 595

                         170       180
                  ....*....|....*....|.
gi 1375023219 539 SVEALK--YSMKTSSAEMPTI 557
Cdd:pfam17380 596 PITTIKpiYRPRISEYQPPDV 616
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
373-516 8.93e-04

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 42.59  E-value: 8.93e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  373 AHAHRRIDQLNRELAQQKATEKQHIELALEKHKLEEkrtfDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMR----- 447
Cdd:COG4913    647 REALQRLAEYSWDEIDVASAEREIAELEAELERLDA----SSDDLAALEEQLEELEAELEELEEELDELKGEIGRlekel 722

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  448 TQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSE-KLSEQELEFRRRSQEQMDSFTLDINTAYARLRGI 516
Cdd:COG4913    723 EQAEEELDELQDRLEAAEDLARLELRALLEERFAAaLGDAVERELRENLEERIDALRARLNRAEEELERA 792
COG4223 COG4223
Uncharacterized conserved protein [Function unknown];
480-714 1.51e-03

Uncharacterized conserved protein [Function unknown];


Pssm-ID: 443367 [Multi-domain]  Cd Length: 259  Bit Score: 41.19  E-value: 1.51e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 480 LSEKLSEQELEFRRRSQEQMDsftLDINTAYARLRGIEQAVQSHAVAEEEARKAHQLWLSVEALKYSMKTSSaemptiPL 559
Cdd:COG4223    39 LEARLAALRAALAAAREAVAA---AAAAALEARLAALEAKAAAPEAEAAAAARAAALALAAAALRAAVERGQ------PF 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 560 GSAVEAIRVNCSDNEFTQALTAAippesLTRGVYSEETLRARFYAVQKLARRVAMIDETRNSLYQYFLSYLQSLLlfppk 639
Cdd:COG4223   110 AAELAALEALAPDAPALAALAAF-----AATGVPTLAALRAEFPAAARAALAAARAPEADASWLDRLLAFARSLV----- 179

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1375023219 640 QLKPPAElyPEDINTFKLLSYASYCIEHGDLELAAKFVNQLKGESRRVAQDWLKEARMTLETKQIVEILTAYASA 714
Cdd:COG4223   180 TVRRVGP--VEGDDPDAILARAEAALAAGDLAGALAELEALPEAAQAAAAPWIAKAEARLAADAALQALAAQALA 252
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 384-533 2.17e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.46  E-value: 2.17e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 384 RELaQQKATEKQHIELALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRdamenEMRTQLRRQAAAHTDHLRD 463
Cdd:COG1196   216 REL-KEELKELEAELLLLKLRELEAELEELEAELEELEAELEELEAELAELEAELE-----ELRLELEELELELEEAQAE 289

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 464 VLKVQEQELKYEFEQGLSEKLSEQELEFRRRSQEQMDSFTLDINTAYARLRGIEQAVQSHAVAEEEARKA 533
Cdd:COG1196   290 EYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELEEAEAE 359
sbcc TIGR00618
exonuclease SbcC; All proteins in this family for which functions are known are part of an ...
 380-498 2.71e-03

exonuclease SbcC; All proteins in this family for which functions are known are part of an exonuclease complex with sbcD homologs. This complex is involved in the initiation of recombination to regulate the levels of palindromic sequences in DNA. This family is based on the phylogenomic analysis of JA Eisen (1999, Ph.D. Thesis, Stanford University). [DNA metabolism, DNA replication, recombination, and repair]


Pssm-ID: 129705 [Multi-domain]  Cd Length: 1042  Bit Score: 41.11  E-value: 2.71e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  380 DQLNRELAQQKATEKQHIELALEKHKLEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEVRDAMENEMRTQLRRQAAAHtd 459
Cdd:TIGR00618  256 LKKQQLLKQLRARIEELRAQEAVLEETQERINRARKAAPLAAHIKAVTQIEQQAQRIHTELQSKMRSRAKLLMKRAAH-- 333

                           90       100       110
                   ....*....|....*....|....*....|....*....
gi 1375023219  460 hlrdvlkvQEQELKYEFEQGLSEKLSEQELEFRRRSQEQ 498
Cdd:TIGR00618  334 --------VKQQSSIEEQRRLLQTLHSQEIHIRDAHEVA 364
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 258-495 2.90e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 40.52  E-value: 2.90e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 258 AADALLKAKEELEKMKTIIEdAKKREIAGATPHITAAEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFR 337
Cdd:COG4942    18 QADAAAEAEAELEQLQQEIA-ELEKELAALKKEEKALLKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAELR 96

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 338 KELDSITPDITP----GWKGMSISDLAGKLSTDDLNSLIAHAhRRIDQLNRELAQQ-KATEKQHIELALEKHKLEEKRTF 412
Cdd:COG4942    97 AELEAQKEELAEllraLYRLGRQPPLALLLSPEDFLDAVRRL-QYLKYLAPARREQaEELRADLAELAALRAELEAERAE 175

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 413 DSAVAKALEHHRSEIQAEQDRKveevrdameNEMRTQLRRQAAAHTDHLRDvLKVQEQELkyefeQGLSEKLSEQELEFR 492
Cdd:COG4942   176 LEALLAELEEERAALEALKAER---------QKLLARLEKELAELAAELAE-LQQEAEEL-----EALIARLEAEAAAAA 240


                  ...
gi 1375023219 493 RRS 495
Cdd:COG4942   241 ERT 243
PTZ00121 PTZ00121
MAEBL; Provisional
 224-502 4.09e-03

MAEBL; Provisional


Pssm-ID: 173412 [Multi-domain]  Cd Length: 2084  Bit Score: 40.89  E-value: 4.09e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  224 KTAMDNSEIAGEKKSA-QWRTVEGALK--ERRKAVDEAADALLKAKEELEKMKTI--IEDAKKREIAGATPHITA----- 293
Cdd:PTZ00121  1509 KKKADEAKKAEEAKKAdEAKKAEEAKKadEAKKAEEKKKADELKKAEELKKAEEKkkAEEAKKAEEDKNMALRKAeeakk 1588

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  294 AEGRLHNMIVDLDNVVKKVQAAQSEAKVVSQYHELVVQARDDFRKELDSITPDITPGWKG---MSISDLAGKLSTDDLNS 370
Cdd:PTZ00121  1589 AEEARIEEVMKLYEEEKKMKAEEAKKAEEAKIKAEELKKAEEEKKKVEQLKKKEAEEKKKaeeLKKAEEENKIKAAEEAK 1668

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  371 LIAHAHRRIDQLNRELAQQKATEKQHIELALEKHKLEEKRTFDSAVAKALEHHRSEiQAEQDRKVEEVRDAMENEMRT-- 448
Cdd:PTZ00121  1669 KAEEDKKKAEEAKKAEEDEKKAAEALKKEAEEAKKAEELKKKEAEEKKKAEELKKA-EEENKIKAEEAKKEAEEDKKKae 1747

                          250       260       270       280       290       300
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219  449 QLRRQAAAHTD--HLRDVLKVQEQELKYE----FEQGLSEKLSEQELEFRRRSQEQMDSF 502
Cdd:PTZ00121  1748 EAKKDEEEKKKiaHLKKEEEKKAEEIRKEkeavIEEELDEEDEKRRMEVDKKIKDIFDNF 1807
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 182-490 5.62e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 40.31  E-value: 5.62e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 182 SETTALAKSLEDALNRTSSVTLQTITAQNAAVQAVKAHsNILKTAMDNSEIAGE-----KKSAQWRTVEGAL-------K 249
Cdd:COG1196   456 EEEEALLELLAELLEEAALLEAALAELLEELAEAAARL-LLLLEAEADYEGFLEgvkaaLLLAGLRGLAGAVavligveA 534

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 250 ERRKAVDEAADALLKAK--EELEKMKTIIEDAKKREIAGAT--PHITAAEGRLHNMIVDLDNVVKKVQAAQSEAkvvsQY 325
Cdd:COG1196   535 AYEAALEAALAAALQNIvvEDDEVAAAAIEYLKAAKAGRATflPLDKIRARAALAAALARGAIGAAVDLVASDL----RE 610

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 326 HELVVQARDDFRKELDSITPDITPGWKGMSISDLAGKLSTDDLNSLIAHAHRRIDQLNRELAQQKATEKQHIELALEKHK 405
Cdd:COG1196   611 ADARYYVLGDTLLGRTLVAARLEAALRRAVTLAGRLREVTLEGEGGSAGGSLTGGSRRELLAALLEAEAELEELAERLAE 690

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1375023219 406 LEEKRTFDSAVAKALEHHRSEIQAEQDRKVEEvrdamENEMRTQLRRQAAAHTDHLRDVLKVQEQELKYEFEQGLSEKLS 485
Cdd:COG1196   691 EELELEEALLAEEEEERELAEAEEERLEEELE-----EEALEEQLEAEREELLEELLEEEELLEEEALEELPEPPDLEEL 765


                  ....*
gi 1375023219 486 EQELE 490
Cdd:COG1196   766 ERELE 770
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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