NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1376477404|ref|NP_001349294|]
View 

uncharacterized protein LOC108168395 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

CATH:  3.30.160.60|1.10.287.1360
Gene Ontology:  GO:0003700|GO:0005515|GO:0008270|GO:0003677|GO:0006355|GO:0001217
PubMed:  22803940|8183940|2023909|8183939|10748030|27867147|28765213|11361095|30718982|10940247
SCOP:  4003583|4002243

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 1.29e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.05  E-value: 1.29e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1376477404   4 VTYDDVHVNLTREEWALLDPSQKRLYKDVMLETYKNLTAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
116-538 1.15e-15

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 79.35  E-value: 1.15e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477404 116 HSNLQTHKRTHPKE----KPYKCDQCDKAYSQHSHLQRHKRKHTGEKPYECKQCGKAFAYH--SELQSHERIHTGEKPYK 189
Cdd:COG5048    14 SVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477404 190 CNQCGKAFAHhcNLRVHKIIHTGEKPYKCNQCD-KAYSQHCNLQIHKSTHTGEKSYKCNQCGKAFVYYGYLQRHKTTHTG 268
Cdd:COG5048    94 NSKSLPLSNS--KASSSSLSSSSSNSNDNNLLSsHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPL 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477404 269 EKPYKCNLCGKAFASHrylqVHKSTHTGEKPHECNQCGKAFVYHDHLQIHKRTHTGEKPYECNHCG----KTFAAHRYLQ 344
Cdd:COG5048   172 PANSLSKDPSSNLSLL----ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSqlspKSLLSQSPSS 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477404 345 VHKRTHTGEKP--YECNQCGKAFASHSYLQVHKRTHTG-EKPYECSQCDKAFAYPGYLQVHKRT--HTGE--KPYEC--N 415
Cdd:COG5048   248 LSSSDSSSSASesPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpyS 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477404 416 QCGKAFAGQNVLKRHEKIHTGEKPYIC--NECGKAFVSN------TSLQIHKATHTgEKPYEC--KQCSKSFASHGQLQS 485
Cdd:COG5048   328 LCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLlnneppQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSL 406

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1376477404 486 HEIIHTGEKP--YKCNGCDKAYSRHSHLQRHKRTHTMTVTNVIEPLQVTVIFKGM 538
Cdd:COG5048   407 HIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 1.29e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.05  E-value: 1.29e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1376477404   4 VTYDDVHVNLTREEWALLDPSQKRLYKDVMLETYKNLTAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 3.10e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.71  E-value: 3.10e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1376477404    4 VTYDDVHVNLTREEWALLDPSQKRLYKDVMLETYKNLTAIGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 1.04e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 73.74  E-value: 1.04e-16
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1376477404   4 VTYDDVHVNLTREEWALLDPSQKRLYKDVMLETYKNLT 41
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
116-538 1.15e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 79.35  E-value: 1.15e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477404 116 HSNLQTHKRTHPKE----KPYKCDQCDKAYSQHSHLQRHKRKHTGEKPYECKQCGKAFAYH--SELQSHERIHTGEKPYK 189
Cdd:COG5048    14 SVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477404 190 CNQCGKAFAHhcNLRVHKIIHTGEKPYKCNQCD-KAYSQHCNLQIHKSTHTGEKSYKCNQCGKAFVYYGYLQRHKTTHTG 268
Cdd:COG5048    94 NSKSLPLSNS--KASSSSLSSSSSNSNDNNLLSsHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPL 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477404 269 EKPYKCNLCGKAFASHrylqVHKSTHTGEKPHECNQCGKAFVYHDHLQIHKRTHTGEKPYECNHCG----KTFAAHRYLQ 344
Cdd:COG5048   172 PANSLSKDPSSNLSLL----ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSqlspKSLLSQSPSS 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477404 345 VHKRTHTGEKP--YECNQCGKAFASHSYLQVHKRTHTG-EKPYECSQCDKAFAYPGYLQVHKRT--HTGE--KPYEC--N 415
Cdd:COG5048   248 LSSSDSSSSASesPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpyS 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477404 416 QCGKAFAGQNVLKRHEKIHTGEKPYIC--NECGKAFVSN------TSLQIHKATHTgEKPYEC--KQCSKSFASHGQLQS 485
Cdd:COG5048   328 LCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLlnneppQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSL 406

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1376477404 486 HEIIHTGEKP--YKCNGCDKAYSRHSHLQRHKRTHTMTVTNVIEPLQVTVIFKGM 538
Cdd:COG5048   407 HIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
146-171 1.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.02e-04
                          10        20
                  ....*....|....*....|....*.
gi 1376477404 146 HLQRHKRKHTGEKPYECKQCGKAFAY 171
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 4-44 1.29e-18

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 79.05  E-value: 1.29e-18
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1376477404   4 VTYDDVHVNLTREEWALLDPSQKRLYKDVMLETYKNLTAIG 44
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
4-45 3.10e-17

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 75.71  E-value: 3.10e-17
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1376477404    4 VTYDDVHVNLTREEWALLDPSQKRLYKDVMLETYKNLTAIGY 45
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 4-41 1.04e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 73.74  E-value: 1.04e-16
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1376477404   4 VTYDDVHVNLTREEWALLDPSQKRLYKDVMLETYKNLT 41
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
116-538 1.15e-15

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 79.35  E-value: 1.15e-15
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477404 116 HSNLQTHKRTHPKE----KPYKCDQCDKAYSQHSHLQRHKRKHTGEKPYECKQCGKAFAYH--SELQSHERIHTGEKPYK 189
Cdd:COG5048    14 SVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSrpLELSRHLRTHHNNPSDL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477404 190 CNQCGKAFAHhcNLRVHKIIHTGEKPYKCNQCD-KAYSQHCNLQIHKSTHTGEKSYKCNQCGKAFVYYGYLQRHKTTHTG 268
Cdd:COG5048    94 NSKSLPLSNS--KASSSSLSSSSSNSNDNNLLSsHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPL 171

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477404 269 EKPYKCNLCGKAFASHrylqVHKSTHTGEKPHECNQCGKAFVYHDHLQIHKRTHTGEKPYECNHCG----KTFAAHRYLQ 344
Cdd:COG5048   172 PANSLSKDPSSNLSLL----ISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSqlspKSLLSQSPSS 247

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477404 345 VHKRTHTGEKP--YECNQCGKAFASHSYLQVHKRTHTG-EKPYECSQCDKAFAYPGYLQVHKRT--HTGE--KPYEC--N 415
Cdd:COG5048   248 LSSSDSSSSASesPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpyS 327

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477404 416 QCGKAFAGQNVLKRHEKIHTGEKPYIC--NECGKAFVSN------TSLQIHKATHTgEKPYEC--KQCSKSFASHGQLQS 485
Cdd:COG5048   328 LCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLlnneppQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSL 406

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1376477404 486 HEIIHTGEKP--YKCNGCDKAYSRHSHLQRHKRTHTMTVTNVIEPLQVTVIFKGM 538
Cdd:COG5048   407 HIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
zf-H2C2_2 pfam13465
Zinc-finger double domain;
146-171 1.02e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.02e-04
                          10        20
                  ....*....|....*....|....*.
gi 1376477404 146 HLQRHKRKHTGEKPYECKQCGKAFAY 171
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
70-430 2.00e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 43.92  E-value: 2.00e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477404  70 TGEKPSVFNTQ-CGKAFACHTYPQRHERIHTREKSYE----------------------GVQYDEALVHHSNLQTHKR-- 124
Cdd:COG5048    57 TGEKPSQCSYSgCDKSFSRPLELSRHLRTHHNNPSDLnskslplsnskasssslsssssNSNDNNLLSSHSLPPSSRDpq 136

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477404 125 ---THPKEKPYKCDQCDKAYSQHSHLQRHKRKHTGEKPYECKQCGKAFAYHselqSHERIHTGEKPYKCNQCGKAFAHHC 201
Cdd:COG5048   137 lpdLLSISNLRNNPLPGNNSSSVNTPQSNSLHPPLPANSLSKDPSSNLSLL----ISSNVSTSIPSSSENSPLSSSYSIP 212

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477404 202 NLRVHKIIHTGEKPYKCNQCDKAYSQHCNLQIHKST------HTGEKSYKCNQCGKAFVYYGYLQRHKTTHTG-EKPYKC 274
Cdd:COG5048   213 SSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLsssdssSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKS 292

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477404 275 NLCGKAFASHRYLQVHKST--HTGE--KPHEC--NQCGKAFVYHDHLQIHKRTHTGEKPYEC--NHCGKTF-----AAHR 341
Cdd:COG5048   293 KQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFspllnNEPP 372

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477404 342 YLQVHKRTHTGEKPYEC--NQCGKAFASHSYLQVHKRTHTGEKPYEC--SQCDKAFAYPGYLQVHKRTHTGEKPYECNQC 417
Cdd:COG5048   373 QSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLLCSIL 452

                         410
                  ....*....|...
gi 1376477404 418 GKaFAGQNVLKRH 430
Cdd:COG5048   453 KS-FRRDLDLSNH 464
zf-H2C2_2 pfam13465
Zinc-finger double domain;
174-199 4.27e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.27e-04
                          10        20
                  ....*....|....*....|....*.
gi 1376477404 174 ELQSHERIHTGEKPYKCNQCGKAFAH 199
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
370-395 7.33e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 7.33e-04
                          10        20
                  ....*....|....*....|....*.
gi 1376477404 370 YLQVHKRTHTGEKPYECSQCDKAFAY 395
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
342-367 8.74e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 8.74e-04
                          10        20
                  ....*....|....*....|....*.
gi 1376477404 342 YLQVHKRTHTGEKPYECNQCGKAFAS 367
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
258-283 1.03e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.03e-03
                          10        20
                  ....*....|....*....|....*.
gi 1376477404 258 YLQRHKTTHTGEKPYKCNLCGKAFAS 283
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
398-422 1.46e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.46e-03
                          10        20
                  ....*....|....*....|....*
gi 1376477404 398 YLQVHKRTHTGEKPYECNQCGKAFA 422
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
314-338 2.43e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.43e-03
                          10        20
                  ....*....|....*....|....*
gi 1376477404 314 HLQIHKRTHTGEKPYECNHCGKTFA 338
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
454-479 3.46e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.46e-03
                          10        20
                  ....*....|....*....|....*.
gi 1376477404 454 SLQIHKATHTGEKPYECKQCSKSFAS 479
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
202-227 3.49e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.49e-03
                          10        20
                  ....*....|....*....|....*.
gi 1376477404 202 NLRVHKIIHTGEKPYKCNQCDKAYSQ 227
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
118-143 3.56e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.56e-03
                          10        20
                  ....*....|....*....|....*.
gi 1376477404 118 NLQTHKRTHPKEKPYKCDQCDKAYSQ 143
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 436-519 3.72e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.70  E-value: 3.72e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477404 436 GEKPYICN--ECGKAFVSNTSLQIHKAThtgekpyecKQCSKSFASHGQLQSHEIIHTGEKPYKCNGCDKAYSRHSHLQR 513
Cdd:COG5189   346 DGKPYKCPveGCNKKYKNQNGLKYHMLH---------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                  ....*.
gi 1376477404 514 HkRTHT 519
Cdd:COG5189   417 H-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 129-207 4.83e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 4.83e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1376477404 129 EKPYKCD--QCDKAYSQHSHLQRHkRKHtgekpyecKQCGKAFAYHSELQSHERIHTGEKPYKCNQCGKAFAHHCNLRVH 206
Cdd:COG5189   347 GKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417


                  .
gi 1376477404 207 K 207
Cdd:COG5189   418 R 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
427-451 8.80e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.80e-03
                          10        20
                  ....*....|....*....|....*
gi 1376477404 427 LKRHEKIHTGEKPYICNECGKAFVS 451
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
286-311 9.99e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.99e-03
                          10        20
                  ....*....|....*....|....*.
gi 1376477404 286 YLQVHKSTHTGEKPHECNQCGKAFVY 311
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH