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Conserved domains on  [gi|1388876057|ref|NP_001350189|]
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cilia- and flagella-associated protein 418 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RMP super family cl20874
Retinal Maintenance; RMP is encoded for by a gene, C8orf37. Mutations in the gene cause two ...
 63-175 1.00e-37

Retinal Maintenance; RMP is encoded for by a gene, C8orf37. Mutations in the gene cause two types of retinal dystrophies: cone-rod dystrophy type 16 (CORD16) and retinitis pigmentosa type 64 (RP64). CORD16 affects the cone receptors which detect red, green or blue wavelengths of light and RP64 affects the cone receptors first and then the rod receptors. Both of these affect the photo-receptors in the eye leading to colour blindness or blindness respectively.


The actual alignment was detected with superfamily member pfam14996:

Pssm-ID: 464431  Cd Length: 154  Bit Score: 126.72  E-value: 1.00e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388876057  63 LDSLINEILEEPNLDKKPSKLKSKS---------SGNTSVRASIEGLGKSCSPVYLGGSSIPCGIGTNIS---------- 123
Cdd:pfam14996   1 LDDLLDEICEEDDKDPKGKPKPISPrpaspgkssDASKSSRASSQAGSKRCCPVYLGGSSVPNGIGTSTSqracdqlrct 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1388876057 124 -------------W---------RNNMPEFHKLKAKLIKKKGTRAYACQCSWRTIEEVTDLQTDHQLRWVCGKH 175
Cdd:pfam14996  81 acdfrvvsfddykWdqscdylffRNNMPDFEKLRAKLKKKPGSRAYACQCSWRSVDELTDLRNDPQLRWVCGKH 154
 
Name Accession Description Interval E-value
RMP pfam14996
Retinal Maintenance; RMP is encoded for by a gene, C8orf37. Mutations in the gene cause two ...
 63-175 1.00e-37

Retinal Maintenance; RMP is encoded for by a gene, C8orf37. Mutations in the gene cause two types of retinal dystrophies: cone-rod dystrophy type 16 (CORD16) and retinitis pigmentosa type 64 (RP64). CORD16 affects the cone receptors which detect red, green or blue wavelengths of light and RP64 affects the cone receptors first and then the rod receptors. Both of these affect the photo-receptors in the eye leading to colour blindness or blindness respectively.


Pssm-ID: 464431  Cd Length: 154  Bit Score: 126.72  E-value: 1.00e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388876057  63 LDSLINEILEEPNLDKKPSKLKSKS---------SGNTSVRASIEGLGKSCSPVYLGGSSIPCGIGTNIS---------- 123
Cdd:pfam14996   1 LDDLLDEICEEDDKDPKGKPKPISPrpaspgkssDASKSSRASSQAGSKRCCPVYLGGSSVPNGIGTSTSqracdqlrct 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1388876057 124 -------------W---------RNNMPEFHKLKAKLIKKKGTRAYACQCSWRTIEEVTDLQTDHQLRWVCGKH 175
Cdd:pfam14996  81 acdfrvvsfddykWdqscdylffRNNMPDFEKLRAKLKKKPGSRAYACQCSWRSVDELTDLRNDPQLRWVCGKH 154
 
Name Accession Description Interval E-value
RMP pfam14996
Retinal Maintenance; RMP is encoded for by a gene, C8orf37. Mutations in the gene cause two ...
 63-175 1.00e-37

Retinal Maintenance; RMP is encoded for by a gene, C8orf37. Mutations in the gene cause two types of retinal dystrophies: cone-rod dystrophy type 16 (CORD16) and retinitis pigmentosa type 64 (RP64). CORD16 affects the cone receptors which detect red, green or blue wavelengths of light and RP64 affects the cone receptors first and then the rod receptors. Both of these affect the photo-receptors in the eye leading to colour blindness or blindness respectively.


Pssm-ID: 464431  Cd Length: 154  Bit Score: 126.72  E-value: 1.00e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1388876057  63 LDSLINEILEEPNLDKKPSKLKSKS---------SGNTSVRASIEGLGKSCSPVYLGGSSIPCGIGTNIS---------- 123
Cdd:pfam14996   1 LDDLLDEICEEDDKDPKGKPKPISPrpaspgkssDASKSSRASSQAGSKRCCPVYLGGSSVPNGIGTSTSqracdqlrct 80

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1388876057 124 -------------W---------RNNMPEFHKLKAKLIKKKGTRAYACQCSWRTIEEVTDLQTDHQLRWVCGKH 175
Cdd:pfam14996  81 acdfrvvsfddykWdqscdylffRNNMPDFEKLRAKLKKKPGSRAYACQCSWRSVDELTDLRNDPQLRWVCGKH 154
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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