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Conserved domains on  [gi|1389998651|ref|NP_001350256|]
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18S rRNA (guanine-N(7))-methyltransferase isoform 5 [Mus musculus]

Protein Classification

class I SAM-dependent methyltransferase( domain architecture ID 10576389)

class I SAM-dependent methyltransferase catalyzes the methylation of one or more specific substrates using S-adenosyl-L-methionine (SAM or AdoMet) as the methyl donor

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WBS_methylT pfam12589
Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in ...
 100-175 1.02e-23

Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in eukaryotes, and is typically between 72 and 83 amino acids in length. The family is found in association with pfam08241. This family is made up of S-adenosylmethionine-dependent methyltransferases. The proteins are deleted in Williams-Beuren syndrome (WBS), a complex developmental disorder with multisystemic manifestations including supravalvular aortic stenosis (SVAS) and a specific cognitive phenotype.


:

Pssm-ID: 432656  Cd Length: 81  Bit Score: 88.84  E-value: 1.02e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389998651 100 LFSGP-STSLPKGLTES-QDADQASESMFTSERAPHKKARRDLVKK---SREWVLEKKERRRRQGKEVRPDTQYTGRKRK 174
Cdd:pfam12589   1 LFVGGvQQQLPKGLGEDgEECSEEQNTVKYERRRRPRKKRKKKGKKavkGREWILRKKERRRRRGKDVPPDSKYTGRKRK 80


                  .
gi 1389998651 175 P 175
Cdd:pfam12589  81 P 81
 
Name Accession Description Interval E-value
WBS_methylT pfam12589
Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in ...
 100-175 1.02e-23

Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in eukaryotes, and is typically between 72 and 83 amino acids in length. The family is found in association with pfam08241. This family is made up of S-adenosylmethionine-dependent methyltransferases. The proteins are deleted in Williams-Beuren syndrome (WBS), a complex developmental disorder with multisystemic manifestations including supravalvular aortic stenosis (SVAS) and a specific cognitive phenotype.


Pssm-ID: 432656  Cd Length: 81  Bit Score: 88.84  E-value: 1.02e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389998651 100 LFSGP-STSLPKGLTES-QDADQASESMFTSERAPHKKARRDLVKK---SREWVLEKKERRRRQGKEVRPDTQYTGRKRK 174
Cdd:pfam12589   1 LFVGGvQQQLPKGLGEDgEECSEEQNTVKYERRRRPRKKRKKKGKKavkGREWILRKKERRRRRGKDVPPDSKYTGRKRK 80


                  .
gi 1389998651 175 P 175
Cdd:pfam12589  81 P 81
 
Name Accession Description Interval E-value
WBS_methylT pfam12589
Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in ...
 100-175 1.02e-23

Methyltransferase involved in Williams-Beuren syndrome; This domain family is found in eukaryotes, and is typically between 72 and 83 amino acids in length. The family is found in association with pfam08241. This family is made up of S-adenosylmethionine-dependent methyltransferases. The proteins are deleted in Williams-Beuren syndrome (WBS), a complex developmental disorder with multisystemic manifestations including supravalvular aortic stenosis (SVAS) and a specific cognitive phenotype.


Pssm-ID: 432656  Cd Length: 81  Bit Score: 88.84  E-value: 1.02e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1389998651 100 LFSGP-STSLPKGLTES-QDADQASESMFTSERAPHKKARRDLVKK---SREWVLEKKERRRRQGKEVRPDTQYTGRKRK 174
Cdd:pfam12589   1 LFVGGvQQQLPKGLGEDgEECSEEQNTVKYERRRRPRKKRKKKGKKavkGREWILRKKERRRRRGKDVPPDSKYTGRKRK 80


                  .
gi 1389998651 175 P 175
Cdd:pfam12589  81 P 81
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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