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Conserved domains on  [gi|1394533234|ref|NP_001350721|]
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peptidyl-prolyl cis-trans isomerase FKBP14 isoform 2 [Mus musculus]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 12144783)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

CATH:  1.10.238.10
Gene Ontology:  GO:0005509
PubMed:  2479149|10191494
SCOP:  3001983

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 1-40 6.70e-15

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


:

Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 64.82  E-value: 6.70e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1394533234   1 MCVGEKRKLTVPPALGYGKEGKG-KIPPESTLIFNIDLLEI 40
Cdd:COG0545    64 MKVGGKRRLVIPPELAYGERGAGgVIPPNSTLVFEVELLDV 104
EF-hand_7 pfam13499
EF-hand domain pair;
47-110 1.57e-04

EF-hand domain pair;


:

Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 37.23  E-value: 1.57e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1394533234  47 HESFQEMDLNDDWRLSKHEVKVYLQKEFEkhgavvNESHHDALVEDIFDKEDEDKDGFISAREF 110
Cdd:pfam13499   5 KEAFKLLDSDGDGYLDVEELKKLLRKLEE------GEPLSDEEVEELFKEFDLDKDGRISFEEF 62
 
Name Accession Description Interval E-value
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 1-40 6.70e-15

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 64.82  E-value: 6.70e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1394533234   1 MCVGEKRKLTVPPALGYGKEGKG-KIPPESTLIFNIDLLEI 40
Cdd:COG0545    64 MKVGGKRRLVIPPELAYGERGAGgVIPPNSTLVFEVELLDV 104
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
1-38 8.43e-15

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 64.53  E-value: 8.43e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1394533234   1 MCVGEKRKLTVPPALGYGKEGK--GKIPPESTLIFNIDLL 38
Cdd:pfam00254  55 MKVGEKRKLTIPPELAYGEEGLagPVIPPNATLVFEVELL 94
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 4-46 1.14e-09

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 54.00  E-value: 1.14e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1394533234   4 GEKRKLTVPPALGYGKEGKGKIPPESTLIFNIDLLEIRNGPRS 46
Cdd:PRK10902  212 GGKIKLVIPPELAYGKAGVPGIPANSTLVFDVELLDVKPAPKA 254
EF-hand_7 pfam13499
EF-hand domain pair;
47-110 1.57e-04

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 37.23  E-value: 1.57e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1394533234  47 HESFQEMDLNDDWRLSKHEVKVYLQKEFEkhgavvNESHHDALVEDIFDKEDEDKDGFISAREF 110
Cdd:pfam13499   5 KEAFKLLDSDGDGYLDVEELKKLLRKLEE------GEPLSDEEVEELFKEFDLDKDGRISFEEF 62
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
21-110 1.89e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 38.23  E-value: 1.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533234  21 GKGKIPPESTLIFNIDLLEIRNGPRSHESFQEMDLNDDWRLSKHEVKVYLqkefEKHGAvvneshHDALVEDIFDKEDED 100
Cdd:COG5126    46 GDGRISREEFVAGMESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLL----TALGV------SEEEADELFARLDTD 115

                          90
                  ....*....|
gi 1394533234 101 KDGFISAREF 110
Cdd:COG5126   116 GDGKISFEEF 125
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 48-110 2.83e-03

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 33.68  E-value: 2.83e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1394533234  48 ESFQEMDLNDDWRLSKHEVKVYLQKEFEKHGavvneshhDALVEDIFDKEDEDKDGFISAREF 110
Cdd:cd00051     4 EAFRLFDKDGDGTISADELKAALKSLGEGLS--------EEEIDEMIREVDKDGDGKIDFEEF 58
 
Name Accession Description Interval E-value
FkpA COG0545
FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein ...
 1-40 6.70e-15

FKBP-type peptidyl-prolyl cis-trans isomerase [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 440311 [Multi-domain]  Cd Length: 104  Bit Score: 64.82  E-value: 6.70e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1394533234   1 MCVGEKRKLTVPPALGYGKEGKG-KIPPESTLIFNIDLLEI 40
Cdd:COG0545    64 MKVGGKRRLVIPPELAYGERGAGgVIPPNSTLVFEVELLDV 104
FKBP_C pfam00254
FKBP-type peptidyl-prolyl cis-trans isomerase;
1-38 8.43e-15

FKBP-type peptidyl-prolyl cis-trans isomerase;


Pssm-ID: 459735  Cd Length: 94  Bit Score: 64.53  E-value: 8.43e-15
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1394533234   1 MCVGEKRKLTVPPALGYGKEGK--GKIPPESTLIFNIDLL 38
Cdd:pfam00254  55 MKVGEKRKLTIPPELAYGEEGLagPVIPPNATLVFEVELL 94
PRK10902 PRK10902
FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional
 4-46 1.14e-09

FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 236791 [Multi-domain]  Cd Length: 269  Bit Score: 54.00  E-value: 1.14e-09
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 1394533234   4 GEKRKLTVPPALGYGKEGKGKIPPESTLIFNIDLLEIRNGPRS 46
Cdd:PRK10902  212 GGKIKLVIPPELAYGKAGVPGIPANSTLVFDVELLDVKPAPKA 254
PRK11570 PRK11570
peptidyl-prolyl cis-trans isomerase; Provisional
 1-40 1.13e-08

peptidyl-prolyl cis-trans isomerase; Provisional


Pssm-ID: 183207 [Multi-domain]  Cd Length: 206  Bit Score: 50.57  E-value: 1.13e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1394533234   1 MCVGEKRKLTVPPALGYGKEGKG-KIPPESTLIFNIDLLEI 40
Cdd:PRK11570  165 MPVGSKWELTIPHELAYGERGAGaSIPPFSTLVFEVELLEI 205
EF-hand_7 pfam13499
EF-hand domain pair;
47-110 1.57e-04

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 37.23  E-value: 1.57e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1394533234  47 HESFQEMDLNDDWRLSKHEVKVYLQKEFEkhgavvNESHHDALVEDIFDKEDEDKDGFISAREF 110
Cdd:pfam13499   5 KEAFKLLDSDGDGYLDVEELKKLLRKLEE------GEPLSDEEVEELFKEFDLDKDGRISFEEF 62
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
21-110 1.89e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 38.23  E-value: 1.89e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1394533234  21 GKGKIPPESTLIFNIDLLEIRNGPRSHESFQEMDLNDDWRLSKHEVKVYLqkefEKHGAvvneshHDALVEDIFDKEDED 100
Cdd:COG5126    46 GDGRISREEFVAGMESLFEATVEPFARAAFDLLDTDGDGKISADEFRRLL----TALGV------SEEEADELFARLDTD 115

                          90
                  ....*....|
gi 1394533234 101 KDGFISAREF 110
Cdd:COG5126   116 GDGKISFEEF 125
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
50-111 2.37e-04

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 38.23  E-value: 2.37e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1394533234  50 FQEMDLNDDWRLSKhevkvylqKEFEKHGAVVNESHHDALVEDIFDKEDEDKDGFISAREFT 111
Cdd:COG5126    39 FSEADTDGDGRISR--------EEFVAGMESLFEATVEPFARAAFDLLDTDGDGKISADEFR 92
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 48-110 2.83e-03

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 33.68  E-value: 2.83e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1394533234  48 ESFQEMDLNDDWRLSKHEVKVYLQKEFEKHGavvneshhDALVEDIFDKEDEDKDGFISAREF 110
Cdd:cd00051     4 EAFRLFDKDGDGTISADELKAALKSLGEGLS--------EEEIDEMIREVDKDGDGKIDFEEF 58
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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