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Conserved domains on  [gi|1395447035|ref|NP_001350985|]
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Potassium channel domain-containing protein [Caenorhabditis elegans]

Protein Classification

potassium channel family protein( domain architecture ID 10545436)

potassium channel family protein spans the cell membrane to form a conduction pathway or pore, through which selective ions such as potassium, sodium, and calcium, translocate across cell membranes

Gene Ontology:  GO:0005267|GO:0034220|GO:0005216|GO:0071805|GO:0016020
PubMed:  15816170|9525859|11836519|11178249|1772658
SCOP:  4000034
TCDB:  1.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 163-220 9.17e-18

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


:

Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 78.85  E-value: 9.17e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1395447035  163 MWTTSSALFFAATTMATIGYGNIVPVTPLGRLACVLFALFGAPIAIITIGDLGKFLSE 220
Cdd:pfam07885   21 EWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFLTE 78
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 285-360 4.79e-16

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


:

Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 74.23  E-value: 4.79e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1395447035  285 TIILLYIAFGGILFSILEDW--SYMDAFYYSFISLTTIGFGDIVPENHDYIAIMLIYLGVGLSVTTMCIDLAGIQYIQ 360
Cdd:pfam07885    1 IVLLLVLIFGTVYYLLEEGWewSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFLTE 78
 
Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 163-220 9.17e-18

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 78.85  E-value: 9.17e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1395447035  163 MWTTSSALFFAATTMATIGYGNIVPVTPLGRLACVLFALFGAPIAIITIGDLGKFLSE 220
Cdd:pfam07885   21 EWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFLTE 78
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 285-360 4.79e-16

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 74.23  E-value: 4.79e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1395447035  285 TIILLYIAFGGILFSILEDW--SYMDAFYYSFISLTTIGFGDIVPENHDYIAIMLIYLGVGLSVTTMCIDLAGIQYIQ 360
Cdd:pfam07885    1 IVLLLVLIFGTVYYLLEEGWewSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFLTE 78
PRK10537 PRK10537
voltage-gated potassium channel protein;
156-194 6.31e-04

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 43.86  E-value: 6.31e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1395447035  156 GDRGSEKMWTTSSALFFAATTMATIGYGNIVPVTPLGRL 194
Cdd:PRK10537   159 GDGFSPPIESLSTAFYFSIVTMSTVGYGDIVPVSESARL 197
PRK10537 PRK10537
voltage-gated potassium channel protein;
284-349 1.19e-03

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 42.70  E-value: 1.19e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1395447035  284 FTIILLYIAFGGILFS------ILedwSYMDAFYYSFISLTTIGFGDIVPENHD--YIAIMLIYLGVGLSVTTM 349
Cdd:PRK10537   144 ITSLLFYSTFGALYLGdgfsppIE---SLSTAFYFSIVTMSTVGYGDIVPVSESarLFTISVIILGITVFATSI 214
 
Name Accession Description Interval E-value
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 163-220 9.17e-18

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 78.85  E-value: 9.17e-18
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*...
gi 1395447035  163 MWTTSSALFFAATTMATIGYGNIVPVTPLGRLACVLFALFGAPIAIITIGDLGKFLSE 220
Cdd:pfam07885   21 EWSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFLTE 78
Ion_trans_2 pfam07885
Ion channel; This family includes the two membrane helix type ion channels found in bacteria.
 285-360 4.79e-16

Ion channel; This family includes the two membrane helix type ion channels found in bacteria.


Pssm-ID: 462301 [Multi-domain]  Cd Length: 78  Bit Score: 74.23  E-value: 4.79e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1395447035  285 TIILLYIAFGGILFSILEDW--SYMDAFYYSFISLTTIGFGDIVPENHDYIAIMLIYLGVGLSVTTMCIDLAGIQYIQ 360
Cdd:pfam07885    1 IVLLLVLIFGTVYYLLEEGWewSFLDALYFSFVTLTTVGYGDIVPLTDAGRLFTIFYILIGIPLFAIFLAVLGRFLTE 78
PRK10537 PRK10537
voltage-gated potassium channel protein;
156-194 6.31e-04

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 43.86  E-value: 6.31e-04
                           10        20        30
                   ....*....|....*....|....*....|....*....
gi 1395447035  156 GDRGSEKMWTTSSALFFAATTMATIGYGNIVPVTPLGRL 194
Cdd:PRK10537   159 GDGFSPPIESLSTAFYFSIVTMSTVGYGDIVPVSESARL 197
PRK10537 PRK10537
voltage-gated potassium channel protein;
284-349 1.19e-03

voltage-gated potassium channel protein;


Pssm-ID: 236711 [Multi-domain]  Cd Length: 393  Bit Score: 42.70  E-value: 1.19e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1395447035  284 FTIILLYIAFGGILFS------ILedwSYMDAFYYSFISLTTIGFGDIVPENHD--YIAIMLIYLGVGLSVTTM 349
Cdd:PRK10537   144 ITSLLFYSTFGALYLGdgfsppIE---SLSTAFYFSIVTMSTVGYGDIVPVSESarLFTISVIILGITVFATSI 214
Ion_trans pfam00520
Ion transport protein; This family contains sodium, potassium and calcium ion channels. This ...
 280-342 3.45e-03

Ion transport protein; This family contains sodium, potassium and calcium ion channels. This family is 6 transmembrane helices in which the last two helices flank a loop which determines ion selectivity. In some sub-families (e.g. Na channels) the domain is repeated four times, whereas in others (e.g. K channels) the protein forms as a tetramer in the membrane.


Pssm-ID: 459842 [Multi-domain]  Cd Length: 238  Bit Score: 40.71  E-value: 3.45e-03
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1395447035  280 VLMVFTIILLYIaFGGILFSILEDW-------SYMDAFYYSFISLTTIGFGDIVPE--NHDYIAIMLIYLGV 342
Cdd:pfam00520  139 FLFIFAIIGYQL-FGGKLKTWENPDngrtnfdNFPNAFLWLFQTMTTEGWGDIMYDtiDGKGEFWAYIYFVS 209
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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