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Conserved domains on  [gi|1396658795|ref|NP_001351036|]
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cadherin-12 isoform 1 preproprotein [Homo sapiens]

Protein Classification

cadherin( domain architecture ID 10638918)

cadherin is a glycoprotein involved in Ca2+-mediated cell-cell adhesion

CATH:  2.60.40.60
Gene Ontology:  GO:0007156|GO:0005509
PubMed:  28268172
SCOP:  4007535

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 724-783 6.13e-33

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


:

Pssm-ID: 460041  Cd Length: 60  Bit Score: 121.11  E-value: 6.13e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795 724 NDVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLADMFG 783
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 164-265 7.40e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.56  E-value: 7.40e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795 164 PYVATVPEMSPVGAYVLQVKATDADDptyGNSARVVYSILQGQP--YFSIDPKTGVIRTALPnMDREVKEQYQVLIQAKD 241
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....
gi 1396658795 242 MGGQlgGLAGTTIVNITLTDVNDN 265
Cdd:cd11304    77 GGGP--PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 273-380 1.83e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.63  E-value: 1.83e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795 273 IFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIvtdeDTQEGVIKLKKPLDFETKKAYTFKVEASN 352
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....*...
gi 1396658795 353 lhldhrfHSAGPFKDTATVKISVLDVDE 380
Cdd:cd11304    77 -------GGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 389-484 5.54e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.39  E-value: 5.54e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795 389 YTMEVYEDTPVGTIIGAVTAQDLDVGSSA-VRYFIDwKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNP 467
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGeVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*..
gi 1396658795 468 LLTSKVNILINVLDVNE 484
Cdd:cd11304    81 PLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 80-158 3.82e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


:

Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.40  E-value: 3.82e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795   80 SDLDKGE-GTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETrKPLEPESEFIIKVQDINDNEP 158
Cdd:smart00112   3 TDADSGEnGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGG-PPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 492-590 7.45e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


:

Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.25  E-value: 7.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795 492 PYETAVCENAKPGQIIQIVSAADRDLSPAGqQFSFRLSPEAAIKPnFTVrdfRNNTAGIETRRNGySRRQQELYFLPVVI 571
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDGL-FSI---DPSTGEITTAKPL-DREEQSSYTLTVTA 74

                          90
                  ....*....|....*....
gi 1396658795 572 EDSSYPVQSSTNTMTIRVC 590
Cdd:cd11304    75 TDGGGPPLSSTATVTITVL 93
 
Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 724-783 6.13e-33

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 121.11  E-value: 6.13e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795 724 NDVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLADMFG 783
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 164-265 7.40e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.56  E-value: 7.40e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795 164 PYVATVPEMSPVGAYVLQVKATDADDptyGNSARVVYSILQGQP--YFSIDPKTGVIRTALPnMDREVKEQYQVLIQAKD 241
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....
gi 1396658795 242 MGGQlgGLAGTTIVNITLTDVNDN 265
Cdd:cd11304    77 GGGP--PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 273-380 1.83e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.63  E-value: 1.83e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795 273 IFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIvtdeDTQEGVIKLKKPLDFETKKAYTFKVEASN 352
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....*...
gi 1396658795 353 lhldhrfHSAGPFKDTATVKISVLDVDE 380
Cdd:cd11304    77 -------GGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 389-484 5.54e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.39  E-value: 5.54e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795 389 YTMEVYEDTPVGTIIGAVTAQDLDVGSSA-VRYFIDwKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNP 467
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGeVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*..
gi 1396658795 468 LLTSKVNILINVLDVNE 484
Cdd:cd11304    81 PLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 183-267 1.76e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.95  E-value: 1.76e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795  183 KATDADDptyGNSARVVYSILQG--QPYFSIDPKTGVIRTALPnMDREVKEQYQVLIQAKDMGGQlgGLAGTTIVNITLT 260
Cdd:smart00112   1 SATDADS---GENGKVTYSILSGndDGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGP--PLSSTATVTITVL 74


                   ....*..
gi 1396658795  261 DVNDNPP 267
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
165-260 1.42e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.89  E-value: 1.42e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795 165 YVATVPEMSPVGAYVLQVKATDADDPTygnSARVVYSILQGQPY--FSIDPKTGVIRTALPnMDREVKEQYQVLIQAKDM 242
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP---NGRIFYSILGGGPGgnFRIDPDTGDISTTKP-LDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*...
gi 1396658795 243 GGQlgGLAGTTIVNITLT 260
Cdd:pfam00028  77 GGP--PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 80-158 3.82e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.40  E-value: 3.82e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795   80 SDLDKGE-GTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETrKPLEPESEFIIKVQDINDNEP 158
Cdd:smart00112   3 TDADSGEnGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGG-PPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 73-156 8.02e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.98  E-value: 8.02e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795  73 QYVGKLH-SDLDKGE-GTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETrKPLEPESEFIIKV 150
Cdd:cd11304    14 TVVLTVSaTDPDSGEnGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG-PPLSSTATVTITV 92


                  ....*.
gi 1396658795 151 QDINDN 156
Cdd:cd11304    93 LDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 292-382 4.07e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 79.32  E-value: 4.07e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795  292 RAVDPDFGQNAEIEYNIVPGDGGNLFDIvtdeDTQEGVIKLKKPLDFETKKAYTFKVEASNlhldhrfHSAGPFKDTATV 371
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATD-------GGGPPLSSTATV 69

                           90
                   ....*....|..
gi 1396658795  372 KISVLDV-DEPP 382
Cdd:smart00112  70 TITVLDVnDNAP 81
Cadherin pfam00028
Cadherin domain;
274-376 1.83e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.11  E-value: 1.83e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795 274 FHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIvtdeDTQEGVIKLKKPLDFETKKAYTFKVEASNl 353
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEATD- 75

                          90       100
                  ....*....|....*....|...
gi 1396658795 354 hldhrfHSAGPFKDTATVKISVL 376
Cdd:pfam00028  76 ------SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 407-487 2.49e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.39  E-value: 2.49e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795  407 TAQDLDVGSSA-VRYFIDwKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVNEF 485
Cdd:smart00112   1 SATDADSGENGkVTYSIL-SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 1396658795  486 PP 487
Cdd:smart00112  80 AP 81
Cadherin pfam00028
Cadherin domain;
389-480 5.80e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.87  E-value: 5.80e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795 389 YTMEVYEDTPVGTIIGAVTAQDLDVGS-SAVRYFIDwKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNP 467
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPnGRIFYSIL-GGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 1396658795 468 LLTSKVNILINVL 480
Cdd:pfam00028  80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
68-151 2.17e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.78  E-value: 2.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795  68 VGSEPQYVGKLHSDLDKGeGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDiETRKPLEPESEFI 147
Cdd:pfam00028  11 VGTEVLTVTATDPDLGPN-GRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD-SGGPPLSSTATVT 88


                  ....
gi 1396658795 148 IKVQ 151
Cdd:pfam00028  89 ITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 492-590 7.45e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.25  E-value: 7.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795 492 PYETAVCENAKPGQIIQIVSAADRDLSPAGqQFSFRLSPEAAIKPnFTVrdfRNNTAGIETRRNGySRRQQELYFLPVVI 571
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDGL-FSI---DPSTGEITTAKPL-DREEQSSYTLTVTA 74

                          90
                  ....*....|....*....
gi 1396658795 572 EDSSYPVQSSTNTMTIRVC 590
Cdd:cd11304    75 TDGGGPPLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
493-590 1.16e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.07  E-value: 1.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795 493 YETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAikPNFTVrdfRNNTAGIETRRNgYSRRQQELYFLPVVIE 572
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPG--GNFRI---DPDTGDISTTKP-LDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 1396658795 573 DSSYPVQSSTNTMTIRVC 590
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 511-590 5.71e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 39.26  E-value: 5.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795  511 SAADRDlSPAGQQFSFRLSPEAAiKPNFTVrdfrNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVC 590
Cdd:smart00112   1 SATDAD-SGENGKVTYSILSGND-DGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
 
Name Accession Description Interval E-value
CADH_Y-type_LIR pfam01049
Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting ...
 724-783 6.13e-33

Cadherin, Y-type LIR-motif; LC3 Interacting Regions (LIRs), also known as ATG8-interacting motifs (AIMs), are short-linear motifs (SLiMs) of autophagy receptors and adaptor proteins that facilitates the selective recruitment of autophagy substrates to the autophagosome. LIRs are characterized by degenerated sequences with a four-residue core central sequence involved in ATG8-binding, with the W/Y/FxxL/I/V pattern. Based on the aromatic amino acid in position 1 they can be classified into W-type, Y-type and F-type. This entry includes three conserved LIR motifs of CADHs, which two are Y-type (YDxL/I) and one F-type (FKKL), while a fourth LIR (YGGV) is only present in CADH6 members. Cadherins (CADH) have a crucial role in epithelial-to-mesenchymal transition (EMT), involved in migration properties of tumour cells. CADH6 is an EMT marker in thyroid cancer that interacts with the ATG8 family members GABARAP, BNIP3 and BNIP3L restraining autophagy through LIR domains, a common feature among many cadherin family members.


Pssm-ID: 460041  Cd Length: 60  Bit Score: 121.11  E-value: 6.13e-33
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795 724 NDVDPTAPPYDSLATYAYEGSGSVAESLSSIDSLTTEADQDYDYLTDWGPRFKVLADMFG 783
Cdd:pfam01049   1 ADNDPSAPPYDSLQTYAYEGDGSSAGSLSSLESSTSDSDQDYDYLSDWGPRFKKLAELYG 60
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 164-265 7.40e-30

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 113.56  E-value: 7.40e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795 164 PYVATVPEMSPVGAYVLQVKATDADDptyGNSARVVYSILQGQP--YFSIDPKTGVIRTALPnMDREVKEQYQVLIQAKD 241
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDS---GENGEVTYSIVSGNEdgLFSIDPSTGEITTAKP-LDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....
gi 1396658795 242 MGGQlgGLAGTTIVNITLTDVNDN 265
Cdd:cd11304    77 GGGP--PLSSTATVTITVLDVNDN 98
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 273-380 1.83e-27

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 106.63  E-value: 1.83e-27
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795 273 IFHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIvtdeDTQEGVIKLKKPLDFETKKAYTFKVEASN 352
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENGEVTYSIVSGNEDGLFSI----DPSTGEITTAKPLDREEQSSYTLTVTATD 76

                          90       100
                  ....*....|....*....|....*...
gi 1396658795 353 lhldhrfHSAGPFKDTATVKISVLDVDE 380
Cdd:cd11304    77 -------GGGPPLSSTATVTITVLDVND 97
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 389-484 5.54e-26

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 102.39  E-value: 5.54e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795 389 YTMEVYEDTPVGTIIGAVTAQDLDVGSSA-VRYFIDwKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNP 467
Cdd:cd11304     2 YEVSVPENAPPGTVVLTVSATDPDSGENGeVTYSIV-SGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGGP 80

                          90
                  ....*....|....*..
gi 1396658795 468 LLTSKVNILINVLDVNE 484
Cdd:cd11304    81 PLSSTATVTITVLDVND 97
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 183-267 1.76e-21

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 88.95  E-value: 1.76e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795  183 KATDADDptyGNSARVVYSILQG--QPYFSIDPKTGVIRTALPnMDREVKEQYQVLIQAKDMGGQlgGLAGTTIVNITLT 260
Cdd:smart00112   1 SATDADS---GENGKVTYSILSGndDGLFSIDPETGEITTTKP-LDREEQPEYTLTVEATDGGGP--PLSSTATVTITVL 74


                   ....*..
gi 1396658795  261 DVNDNPP 267
Cdd:smart00112  75 DVNDNAP 81
Cadherin pfam00028
Cadherin domain;
165-260 1.42e-19

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 83.89  E-value: 1.42e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795 165 YVATVPEMSPVGAYVLQVKATDADDPTygnSARVVYSILQGQPY--FSIDPKTGVIRTALPnMDREVKEQYQVLIQAKDM 242
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGP---NGRIFYSILGGGPGgnFRIDPDTGDISTTKP-LDRESIGEYELTVEATDS 76

                          90
                  ....*....|....*...
gi 1396658795 243 GGQlgGLAGTTIVNITLT 260
Cdd:pfam00028  77 GGP--PLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 80-158 3.82e-19

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 82.40  E-value: 3.82e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795   80 SDLDKGE-GTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETrKPLEPESEFIIKVQDINDNEP 158
Cdd:smart00112   3 TDADSGEnGKVTYSILSGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGG-PPLSSTATVTITVLDVNDNAP 81
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 73-156 8.02e-19

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 81.98  E-value: 8.02e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795  73 QYVGKLH-SDLDKGE-GTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETrKPLEPESEFIIKV 150
Cdd:cd11304    14 TVVLTVSaTDPDSGEnGEVTYSIVSGNEDGLFSIDPSTGEITTAKPLDREEQSSYTLTVTATDGGG-PPLSSTATVTITV 92


                  ....*.
gi 1396658795 151 QDINDN 156
Cdd:cd11304    93 LDVNDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 292-382 4.07e-18

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 79.32  E-value: 4.07e-18
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795  292 RAVDPDFGQNAEIEYNIVPGDGGNLFDIvtdeDTQEGVIKLKKPLDFETKKAYTFKVEASNlhldhrfHSAGPFKDTATV 371
Cdd:smart00112   1 SATDADSGENGKVTYSILSGNDDGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATD-------GGGPPLSSTATV 69

                           90
                   ....*....|..
gi 1396658795  372 KISVLDV-DEPP 382
Cdd:smart00112  70 TITVLDVnDNAP 81
Cadherin pfam00028
Cadherin domain;
274-376 1.83e-17

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 78.11  E-value: 1.83e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795 274 FHLKVPESSPIGSAIGRIRAVDPDFGQNAEIEYNIVPGDGGNLFDIvtdeDTQEGVIKLKKPLDFETKKAYTFKVEASNl 353
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPGGNFRI----DPDTGDISTTKPLDRESIGEYELTVEATD- 75

                          90       100
                  ....*....|....*....|...
gi 1396658795 354 hldhrfHSAGPFKDTATVKISVL 376
Cdd:pfam00028  76 ------SGGPPLSSTATVTITVL 92
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 407-487 2.49e-17

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 77.39  E-value: 2.49e-17
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795  407 TAQDLDVGSSA-VRYFIDwKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNPLLTSKVNILINVLDVNEF 485
Cdd:smart00112   1 SATDADSGENGkVTYSIL-SGNDDGLFSIDPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVLDVNDN 79


                   ..
gi 1396658795  486 PP 487
Cdd:smart00112  80 AP 81
Cadherin pfam00028
Cadherin domain;
389-480 5.80e-16

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 73.87  E-value: 5.80e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795 389 YTMEVYEDTPVGTIIGAVTAQDLDVGS-SAVRYFIDwKSDGDSYFTIDGNEGTIATNELLDRESTAQYNFSIIASKVSNP 467
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPnGRIFYSIL-GGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATDSGGP 79

                          90
                  ....*....|...
gi 1396658795 468 LLTSKVNILINVL 480
Cdd:pfam00028  80 PLSSTATVTITVL 92
Cadherin pfam00028
Cadherin domain;
68-151 2.17e-11

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 60.78  E-value: 2.17e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795  68 VGSEPQYVGKLHSDLDKGeGTVKYTLSGDGAGTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDiETRKPLEPESEFI 147
Cdd:pfam00028  11 VGTEVLTVTATDPDLGPN-GRIFYSILGGGPGGNFRIDPDTGDISTTKPLDRESIGEYELTVEATD-SGGPPLSSTATVT 88


                  ....
gi 1396658795 148 IKVQ 151
Cdd:pfam00028  89 ITVL 92
Cadherin_repeat cd11304
Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 492-590 7.45e-11

Cadherin tandem repeat domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers.


Pssm-ID: 206637 [Multi-domain]  Cd Length: 98  Bit Score: 59.25  E-value: 7.45e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795 492 PYETAVCENAKPGQIIQIVSAADRDLSPAGqQFSFRLSPEAAIKPnFTVrdfRNNTAGIETRRNGySRRQQELYFLPVVI 571
Cdd:cd11304     1 SYEVSVPENAPPGTVVLTVSATDPDSGENG-EVTYSIVSGNEDGL-FSI---DPSTGEITTAKPL-DREEQSSYTLTVTA 74

                          90
                  ....*....|....*....
gi 1396658795 572 EDSSYPVQSSTNTMTIRVC 590
Cdd:cd11304    75 TDGGGPPLSSTATVTITVL 93
Cadherin pfam00028
Cadherin domain;
493-590 1.16e-08

Cadherin domain;


Pssm-ID: 394985 [Multi-domain]  Cd Length: 92  Bit Score: 53.07  E-value: 1.16e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795 493 YETAVCENAKPGQIIQIVSAADRDLSPAGQQFSFRLSPEAAikPNFTVrdfRNNTAGIETRRNgYSRRQQELYFLPVVIE 572
Cdd:pfam00028   1 YSASVPENAPVGTEVLTVTATDPDLGPNGRIFYSILGGGPG--GNFRI---DPDTGDISTTKP-LDRESIGEYELTVEAT 74

                          90
                  ....*....|....*...
gi 1396658795 573 DSSYPVQSSTNTMTIRVC 590
Cdd:pfam00028  75 DSGGPPLSSTATVTITVL 92
CA_like cd00031
Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell ...
 70-156 5.57e-07

Cadherin repeat-like domain; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. The cadherin repeat domains occur as tandem repeats in the extracellular regions, which are thought to mediate cell-cell contact when bound to calcium. They play numerous roles in cell fate, signalling, proliferation, differentiation, and migration; members include E-, N-, P-, T-, VE-, CNR-, proto-, and FAT-family cadherin, desmocollin, and desmoglein, a large variety of domain architectures with varying repeat copy numbers. Cadherin-repeat containing proteins exist as monomers, homodimers, or heterodimers. This family also includes the cadherin-like repeats of extracellular alpha-dystroglycan.


Pssm-ID: 206635  Cd Length: 98  Bit Score: 48.49  E-value: 5.57e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795  70 SEPQYVGKLHSDLDKgEGTVKYTLSGDGA---GTVFTIDETTGDIHAIRSLDREEKPFYTLRAQAVDIETRKPLEPeSEF 146
Cdd:cd00031    11 SRGSFRVSIPTDLIA-SSGEIIKISAAGKealPSWLHWEPHSGILEGLEKLDREDKGVHYISVSAASLGANVPQTS-SVF 88

                          90
                  ....*....|
gi 1396658795 147 IIKVQDINDN 156
Cdd:cd00031    89 SIEVYDENDN 98
CA smart00112
Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. ...
 511-590 5.71e-04

Cadherin repeats; Cadherins are glycoproteins involved in Ca2+-mediated cell-cell adhesion. Cadherin domains occur as repeats in the extracellular regions which are thought to mediate cell-cell contact when bound to calcium.


Pssm-ID: 214520 [Multi-domain]  Cd Length: 81  Bit Score: 39.26  E-value: 5.71e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1396658795  511 SAADRDlSPAGQQFSFRLSPEAAiKPNFTVrdfrNNTAGIETRRNGYSRRQQELYFLPVVIEDSSYPVQSSTNTMTIRVC 590
Cdd:smart00112   1 SATDAD-SGENGKVTYSILSGND-DGLFSI----DPETGEITTTKPLDREEQPEYTLTVEATDGGGPPLSSTATVTITVL 74
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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