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Conserved domains on  [gi|1399236828|ref|NP_001351144|]
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WD repeat-containing protein 17 isoform 3 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 13234759)

WD40 repeat domain-containing protein folds into a beta-propeller structure and functions as a scaffold, providing a platform for the interaction and assembly of several proteins into a signalosome; similar to a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
Gene Ontology:  GO:0005515
PubMed:  10322433|8090199|30069656|29026209
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
259-584 3.41e-62

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 218.24  E-value: 3.41e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  259 AFSLPPGHVVCCFLDGGVGLYDMGAKKWDFLRElGHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPGNE 338
Cdd:COG2319     85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  339 GVIFALSWAP-GDLncIAGATSRNGAFIWDIQKGKIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCIIRTVD-GKL 416
Cdd:COG2319    163 GAVTSVAFSPdGKL--LASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSP-DGKLLASGSADGTVRLWDLAtGKL 238

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  417 LHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFYVATssNQPLKVFSGHTARVFHVKWSPlrEG-ILCSGSDDGSVR 494
Cdd:COG2319    239 LRTLTgHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLAT--GELLRTLTGHSGGVNSVAFSP--DGkLLASGSDDGTVR 313

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  495 IWDYTQDACVSTLNGHTAPVRGLMWNteiPY--LLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMAS 572
Cdd:COG2319    314 LWDLATGKLLRTLTGHTGAVRSVAFS---PDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLAS 389

                          330
                   ....*....|..
gi 1399236828  573 CSRDSTVRLWSL 584
Cdd:COG2319    390 GSADGTVRLWDL 401
WD40 super family cl29593
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 90-405 7.83e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


The actual alignment was detected with superfamily member cd00200:

Pssm-ID: 475233 [Multi-domain]  Cd Length: 289  Bit Score: 79.30  E-value: 7.83e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828   90 KVAFGHIDGSISIFQPGSKNQKHVLrpdslegTDEEDPVTALEWDPlSTDYLLVANLHFGIRLLDSESLYCITTFNLPSA 169
Cdd:cd00200     65 YLASGSSDKTIRLWDLETGECVRTL-------TGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  170 AVSvqCLAWVPSapGMFITGDSQVGVLRIWNVSRTTPIDNFKlkktgfhcfhvvnsppkkkfsvqspnknhyisstseav 249
Cdd:cd00200    137 WVN--SVAFSPD--GTFVASSSQDGTIKLWDLRTGKCVATLT-------------------------------------- 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  250 pppnltqnqafslppghvvccfldggvglydmgakkwdflrelGHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLT 329
Cdd:cd00200    175 -------------------------------------------GHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLSTGK 210

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1399236828  330 AVYTSPGNEGVIFALSWAPGDLNCIAGatSRNGAF-IWDIQKGKIIQRFNEHgKNGIFYIAWShKDSKRIATCSGDG 405
Cdd:cd00200    211 CLGTLRGHENGVNSVAFSPDGYLLASG--SEDGTIrVWDLRTGECVQTLSGH-TNSVTSLAWS-PDGKRLASGSADG 283
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
259-584 3.41e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 218.24  E-value: 3.41e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  259 AFSLPPGHVVCCFLDGGVGLYDMGAKKWDFLRElGHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPGNE 338
Cdd:COG2319     85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  339 GVIFALSWAP-GDLncIAGATSRNGAFIWDIQKGKIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCIIRTVD-GKL 416
Cdd:COG2319    163 GAVTSVAFSPdGKL--LASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSP-DGKLLASGSADGTVRLWDLAtGKL 238

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  417 LHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFYVATssNQPLKVFSGHTARVFHVKWSPlrEG-ILCSGSDDGSVR 494
Cdd:COG2319    239 LRTLTgHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLAT--GELLRTLTGHSGGVNSVAFSP--DGkLLASGSDDGTVR 313

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  495 IWDYTQDACVSTLNGHTAPVRGLMWNteiPY--LLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMAS 572
Cdd:COG2319    314 LWDLATGKLLRTLTGHTGAVRSVAFS---PDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLAS 389

                          330
                   ....*....|..
gi 1399236828  573 CSRDSTVRLWSL 584
Cdd:COG2319    390 GSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 293-583 3.36e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 202.57  E-value: 3.36e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  293 GHVETIFDCKFKPDdPNVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGK 372
Cdd:cd00200      7 GHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETGE 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  373 IIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCII-RTVDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRV 450
Cdd:cd00200     85 CVRTLTGH-TSYVSSVAFSP-DGRILSSSSRDKTIKVwDVETGKCLTTLRgHTDWVNSVAFSPDGT-FVASSSQDGTIKL 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  451 FyvATSSNQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISG 530
Cdd:cd00200    162 W--DLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASG 237

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1399236828  531 SWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWS 583
Cdd:cd00200    238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 90-405 7.83e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.30  E-value: 7.83e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828   90 KVAFGHIDGSISIFQPGSKNQKHVLrpdslegTDEEDPVTALEWDPlSTDYLLVANLHFGIRLLDSESLYCITTFNLPSA 169
Cdd:cd00200     65 YLASGSSDKTIRLWDLETGECVRTL-------TGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  170 AVSvqCLAWVPSapGMFITGDSQVGVLRIWNVSRTTPIDNFKlkktgfhcfhvvnsppkkkfsvqspnknhyisstseav 249
Cdd:cd00200    137 WVN--SVAFSPD--GTFVASSSQDGTIKLWDLRTGKCVATLT-------------------------------------- 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  250 pppnltqnqafslppghvvccfldggvglydmgakkwdflrelGHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLT 329
Cdd:cd00200    175 -------------------------------------------GHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLSTGK 210

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1399236828  330 AVYTSPGNEGVIFALSWAPGDLNCIAGatSRNGAF-IWDIQKGKIIQRFNEHgKNGIFYIAWShKDSKRIATCSGDG 405
Cdd:cd00200    211 CLGTLRGHENGVNSVAFSPDGYLLASG--SEDGTIrVWDLRTGECVQTLSGH-TNSVTSLAWS-PDGKRLASGSADG 283
WD40 COG2319
WD40 repeat [General function prediction only];
54-327 5.03e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.17  E-value: 5.03e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828   54 LIWTISGPDSGV-SVhkeahSFASDicifrwhtqkkGK-VAFGHIDGSISIFQPGSKNQKHVLRPDSlegtdeeDPVTAL 131
Cdd:COG2319    154 LLRTLTGHSGAVtSV-----AFSPD-----------GKlLASGSDDGTVRLWDLATGKLLRTLTGHT-------GAVRSV 210

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  132 EWDPlstD--YLLVANLHFGIRLLDSESLYCITTFNLPSAAVSvqCLAWVPSapGMFITGDSQVGVLRIWNVSRTTPIDN 209
Cdd:COG2319    211 AFSP---DgkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVR--SVAFSPD--GRLLASGSADGTVRLWDLATGELLRT 283

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  210 FKlkktgfHCFHVVNSppkkkfsVQ-SPNkNHYISSTSE--AVPPPNLTQNQAFSLPPGHV-----VCCFLDGG---VGL 278
Cdd:COG2319    284 LT------GHSGGVNS-------VAfSPD-GKLLASGSDdgTVRLWDLATGKLLRTLTGHTgavrsVAFSPDGKtlaSGS 349

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1399236828  279 YDMGAKKWDF-----LREL-GHVETIFDCKFKPDDpNVLATASFDGTIKVWDINT 327
Cdd:COG2319    350 DDGTVRLWDLatgelLRTLtGHTGAVTSVAFSPDG-RTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 457-497 1.81e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 1.81e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1399236828   457 SNQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWD 497
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 431-584 1.08e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 56.25  E-value: 1.08e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  431 WSQNNKDMIATGCEDKNIRVFYVAtsSNQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVSTLNGh 510
Cdd:PLN00181   540 WNSYIKSQVASSNFEGVVQVWDVA--RSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT- 616

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1399236828  511 TAPVRGLMWNTEIPYLLISGSWDYTIKVWDTRG-GVCLDTVYDHGADVYGLTCHPSRpfTMASCSRDSTVRLWSL 584
Cdd:PLN00181   617 KANICCVQFPSESGRSLAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFVDSS--TLVSSSTDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
458-497 6.37e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 6.37e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1399236828  458 NQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWD 497
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
259-584 3.41e-62

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 218.24  E-value: 3.41e-62
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  259 AFSLPPGHVVCCFLDGGVGLYDMGAKKWDFLRElGHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPGNE 338
Cdd:COG2319     85 AFSPDGRLLASASADGTVRLWDLATGLLLRTLT-GHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHS 162

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  339 GVIFALSWAP-GDLncIAGATSRNGAFIWDIQKGKIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCIIRTVD-GKL 416
Cdd:COG2319    163 GAVTSVAFSPdGKL--LASGSDDGTVRLWDLATGKLLRTLTGH-TGAVRSVAFSP-DGKLLASGSADGTVRLWDLAtGKL 238

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  417 LHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFYVATssNQPLKVFSGHTARVFHVKWSPlrEG-ILCSGSDDGSVR 494
Cdd:COG2319    239 LRTLTgHSGSVRSVAFSPDGR-LLASGSADGTVRLWDLAT--GELLRTLTGHSGGVNSVAFSP--DGkLLASGSDDGTVR 313

                          250       260       270       280       290       300       310       320
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  495 IWDYTQDACVSTLNGHTAPVRGLMWNteiPY--LLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMAS 572
Cdd:COG2319    314 LWDLATGKLLRTLTGHTGAVRSVAFS---PDgkTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLAS 389

                          330
                   ....*....|..
gi 1399236828  573 CSRDSTVRLWSL 584
Cdd:COG2319    390 GSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 293-583 3.36e-58

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 202.57  E-value: 3.36e-58
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  293 GHVETIFDCKFKPDdPNVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGK 372
Cdd:cd00200      7 GHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETGE 84

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  373 IIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCII-RTVDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRV 450
Cdd:cd00200     85 CVRTLTGH-TSYVSSVAFSP-DGRILSSSSRDKTIKVwDVETGKCLTTLRgHTDWVNSVAFSPDGT-FVASSSQDGTIKL 161

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  451 FyvATSSNQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISG 530
Cdd:cd00200    162 W--DLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASG 237

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1399236828  531 SWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWS 583
Cdd:cd00200    238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
259-543 5.43e-52

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 188.58  E-value: 5.43e-52
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  259 AFSlPPGH-VVCCFLDGGVGLYDMGAKKwdFLREL-GHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPG 336
Cdd:COG2319    127 AFS-PDGKtLASGSADGTVRLWDLATGK--LLRTLtGHSGAVTSVAFSPDG-KLLASGSDDGTVRLWDLATGKLLRTLTG 202

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  337 NEGVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGKIIQRFNEHGkNGIFYIAWSHkDSKRIATCSGDG-FCIIRTVDGK 415
Cdd:COG2319    203 HTGAVRSVAFSP-DGKLLASGSADGTVRLWDLATGKLLRTLTGHS-GSVRSVAFSP-DGRLLASGSADGtVRLWDLATGE 279

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  416 LLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFYVATssNQPLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVR 494
Cdd:COG2319    280 LLRTLTgHSGGVNSVAFSPDGK-LLASGSDDGTVRLWDLAT--GKLLRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTVR 355

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....*....
gi 1399236828  495 IWDYTQDACVSTLNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWDTRG 543
Cdd:COG2319    356 LWDLATGELLRTLTGHTGAVTSVAFSPDGRTL-ASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 259-540 6.74e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 164.43  E-value: 6.74e-45
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  259 AFSLPPGHVVCCFLDGGVGLYDMgAKKWDFLRELGHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPGNE 338
Cdd:cd00200     16 AFSPDGKLLATGSGDGTIKVWDL-ETGELLRTLKGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGECVRTLTGHT 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  339 GVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGKIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCII-RTVDGKLL 417
Cdd:cd00200     94 SYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSP-DGTFVASSSQDGTIKLwDLRTGKCV 170

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  418 HKYK-HPAAVFGCDWSQNNKDMIATGCeDKNIRVFYVATSsnQPLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVRIW 496
Cdd:cd00200    171 ATLTgHTGEVNSVAFSPDGEKLLSSSS-DGTIKLWDLSTG--KCLGTLRGHENGVNSVAFSPDGY-LLASGSEDGTIRVW 246

                          250       260       270       280
                   ....*....|....*....|....*....|....*....|....
gi 1399236828  497 DYTQDACVSTLNGHTAPVRGLMWNTEIPYlLISGSWDYTIKVWD 540
Cdd:cd00200    247 DLRTGECVQTLSGHTNSVTSLAWSPDGKR-LASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 333-584 6.12e-44

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 161.35  E-value: 6.12e-44
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  333 TSPGNEGVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGKIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCII-RT 411
Cdd:cd00200      4 TLKGHTGGVTCVAFSP-DGKLLATGSGDGTIKVWDLETGELLRTLKGH-TGPVRDVAASA-DGTYLASGSSDKTIRLwDL 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  412 VDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVFYVATssNQPLKVFSGHTARVFHVKWSPlREGILCSGSDD 490
Cdd:cd00200     81 ETGECVRTLTgHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVET--GKCLTTLRGHTDWVNSVAFSP-DGTFVASSSQD 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  491 GSVRIWDYTQDACVSTLNGHTAPVRGLMWnTEIPYLLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPFtM 570
Cdd:cd00200    157 GTIKLWDLRTGKCVATLTGHTGEVNSVAF-SPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYL-L 234

                          250
                   ....*....|....
gi 1399236828  571 ASCSRDSTVRLWSL 584
Cdd:cd00200    235 ASGSEDGTIRVWDL 248
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 374-584 4.71e-39

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 147.48  E-value: 4.71e-39
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  374 IQRFNEHGKnGIFYIAWsHKDSKRIATCSGDGFCII-RTVDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVF 451
Cdd:cd00200      2 RRTLKGHTG-GVTCVAF-SPDGKLLATGSGDGTIKVwDLETGELLRTLKgHTGPVRDVAASADGT-YLASGSSDKTIRLW 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  452 yvATSSNQPLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISGS 531
Cdd:cd00200     79 --DLETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSS 154

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1399236828  532 WDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRpFTMASCSRDSTVRLWSL 584
Cdd:cd00200    155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDL 206
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 460-585 2.68e-29

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 118.98  E-value: 2.68e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  460 PLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWnteIPY--LLISGSWDYTIK 537
Cdd:cd00200      1 LRRTLKGHTGGVTCVAFSPDGK-LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAA---SADgtYLASGSSDKTIR 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1399236828  538 VWDTRGGVCLDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWSLI 585
Cdd:cd00200     77 LWDLETGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVE 123
WD40 COG2319
WD40 repeat [General function prediction only];
347-584 3.01e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.94  E-value: 3.01e-29
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  347 APGDLNCIAGATSRNGAFIWDIQKGKIIQRFNEHGkNGIFYIAWSHKDSKRIATCSGDGFCIIRTVDGKLLHKYK-HPAA 425
Cdd:COG2319      2 LSADGAALAAASADLALALLAAALGALLLLLLGLA-AAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLgHTAA 80

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  426 VFGCDWSQNNKdMIATGCEDKNIRVFYVATSsnQPLKVFSGHTARVFHVKWSPLREGILcSGSDDGSVRIWDYTQDACVS 505
Cdd:COG2319     81 VLSVAFSPDGR-LLASASADGTVRLWDLATG--LLLRTLTGHTGAVRSVAFSPDGKTLA-SGSADGTVRLWDLATGKLLR 156

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  506 TLNGHTAPVRGLMWNteiP--YLLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHP-SRpfTMASCSRDSTVRLW 582
Cdd:COG2319    157 TLTGHSGAVTSVAFS---PdgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdGK--LLASGSADGTVRLW 231


                   ..
gi 1399236828  583 SL 584
Cdd:COG2319    232 DL 233
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 90-405 7.83e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.30  E-value: 7.83e-16
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828   90 KVAFGHIDGSISIFQPGSKNQKHVLrpdslegTDEEDPVTALEWDPlSTDYLLVANLHFGIRLLDSESLYCITTFNLPSA 169
Cdd:cd00200     65 YLASGSSDKTIRLWDLETGECVRTL-------TGHTSYVSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTD 136

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  170 AVSvqCLAWVPSapGMFITGDSQVGVLRIWNVSRTTPIDNFKlkktgfhcfhvvnsppkkkfsvqspnknhyisstseav 249
Cdd:cd00200    137 WVN--SVAFSPD--GTFVASSSQDGTIKLWDLRTGKCVATLT-------------------------------------- 174

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  250 pppnltqnqafslppghvvccfldggvglydmgakkwdflrelGHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLT 329
Cdd:cd00200    175 -------------------------------------------GHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDLSTGK 210

                          250       260       270       280       290       300       310
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1399236828  330 AVYTSPGNEGVIFALSWAPGDLNCIAGatSRNGAF-IWDIQKGKIIQRFNEHgKNGIFYIAWShKDSKRIATCSGDG 405
Cdd:cd00200    211 CLGTLRGHENGVNSVAFSPDGYLLASG--SEDGTIrVWDLRTGECVQTLSGH-TNSVTSLAWS-PDGKRLASGSADG 283
WD40 COG2319
WD40 repeat [General function prediction only];
54-327 5.03e-12

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.17  E-value: 5.03e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828   54 LIWTISGPDSGV-SVhkeahSFASDicifrwhtqkkGK-VAFGHIDGSISIFQPGSKNQKHVLRPDSlegtdeeDPVTAL 131
Cdd:COG2319    154 LLRTLTGHSGAVtSV-----AFSPD-----------GKlLASGSDDGTVRLWDLATGKLLRTLTGHT-------GAVRSV 210

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  132 EWDPlstD--YLLVANLHFGIRLLDSESLYCITTFNLPSAAVSvqCLAWVPSapGMFITGDSQVGVLRIWNVSRTTPIDN 209
Cdd:COG2319    211 AFSP---DgkLLASGSADGTVRLWDLATGKLLRTLTGHSGSVR--SVAFSPD--GRLLASGSADGTVRLWDLATGELLRT 283

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  210 FKlkktgfHCFHVVNSppkkkfsVQ-SPNkNHYISSTSE--AVPPPNLTQNQAFSLPPGHV-----VCCFLDGG---VGL 278
Cdd:COG2319    284 LT------GHSGGVNS-------VAfSPD-GKLLASGSDdgTVRLWDLATGKLLRTLTGHTgavrsVAFSPDGKtlaSGS 349

                          250       260       270       280       290
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 1399236828  279 YDMGAKKWDF-----LREL-GHVETIFDCKFKPDDpNVLATASFDGTIKVWDINT 327
Cdd:COG2319    350 DDGTVRLWDLatgelLRTLtGHTGAVTSVAFSPDG-RTLASGSADGTVRLWDLAT 403
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 457-497 1.81e-08

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.16  E-value: 1.81e-08
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|.
gi 1399236828   457 SNQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWD 497
Cdd:smart00320    1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 431-584 1.08e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 56.25  E-value: 1.08e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  431 WSQNNKDMIATGCEDKNIRVFYVAtsSNQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVSTLNGh 510
Cdd:PLN00181   540 WNSYIKSQVASSNFEGVVQVWDVA--RSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT- 616

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1399236828  511 TAPVRGLMWNTEIPYLLISGSWDYTIKVWDTRG-GVCLDTVYDHGADVYGLTCHPSRpfTMASCSRDSTVRLWSL 584
Cdd:PLN00181   617 KANICCVQFPSESGRSLAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFVDSS--TLVSSSTDNTLKLWDL 689
PTZ00420 PTZ00420
coronin; Provisional
 458-540 1.95e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 55.34  E-value: 1.95e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  458 NQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQD----------ACVstLNGHTAPVRGLMWNTEIPYLL 527
Cdd:PTZ00420    64 KPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNdesvkeikdpQCI--LKGHKKKISIIDWNPMNYYIM 141

                           90
                   ....*....|...
gi 1399236828  528 ISGSWDYTIKVWD 540
Cdd:PTZ00420   142 CSSGFDSFVNIWD 154
WD40 pfam00400
WD domain, G-beta repeat;
458-497 6.37e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 46.95  E-value: 6.37e-07
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1399236828  458 NQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWD 497
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 503-540 1.27e-06

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.15  E-value: 1.27e-06
                            10        20        30
                    ....*....|....*....|....*....|....*...
gi 1399236828   503 CVSTLNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWD 540
Cdd:smart00320    4 LLKTLKGHTGPVTSVAFSPDGKYL-ASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
503-540 8.09e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 43.87  E-value: 8.09e-06
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1399236828  503 CVSTLNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWD 540
Cdd:pfam00400    3 LLKTLEGHTGSVTSLAFSPDGKLL-ASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 292-380 1.13e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.51  E-value: 1.13e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  292 LGHVETIFDCKFKPDDPNVLATASFDGTIKVWDINT--LTAVYTSP-----GNEGVIFALSWAPGDLNCIAGATSRNGAF 364
Cdd:PTZ00421    72 LGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEegLTQNISDPivhlqGHTKKVGIVSFHPSAMNVLASAGADMVVN 151

                           90
                   ....*....|....*.
gi 1399236828  365 IWDIQKGKIIQRFNEH 380
Cdd:PTZ00421   152 VWDVERGKAVEVIKCH 167
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 365-511 3.87e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.16  E-value: 3.87e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  365 IWDIQKGKIIQRFNEHGKNgIFYIAWSHKDSKRIATCSGDGFCIIRTVD-GKLLHKYKHPAAVFGCDWSQNNKDMIATGC 443
Cdd:PLN00181   559 VWDVARSQLVTEMKEHEKR-VWSIDYSSADPTLLASGSDDGSVKLWSINqGVSIGTIKTKANICCVQFPSESGRSLAFGS 637

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1399236828  444 EDKNIrVFYVATSSNQPLKVFSGHTARVFHVKWspLREGILCSGSDDGSVRIWDYTQDAC------VSTLNGHT 511
Cdd:PLN00181   638 ADHKV-YYYDLRNPKLPLCTMIGHSKTVSYVRF--VDSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHT 708
PTZ00420 PTZ00420
coronin; Provisional
 437-497 5.27e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 47.25  E-value: 5.27e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1399236828  437 DMIATGCEDKNIRVFYVATSSNQ------PLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWD 497
Cdd:PTZ00420    88 EILASGSEDLTIRVWEIPHNDESvkeikdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWD 154
PTZ00420 PTZ00420
coronin; Provisional
 491-607 5.65e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 47.25  E-value: 5.65e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  491 GSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTR-GGVCLDTVYD-------HGADVYGLTC 562
Cdd:PTZ00420    54 GAIRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPhNDESVKEIKDpqcilkgHKKKISIIDW 133

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1399236828  563 HPSRPFTMASCSRDSTVRLWSLIPLITPLQINI---LADRSWDeVIGN 607
Cdd:PTZ00420   134 NPMNYYIMCSSGFDSFVNIWDIENEKRAFQINMpkkLSSLKWN-IKGN 180
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 293-324 1.08e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 40.76  E-value: 1.08e-04
                            10        20        30
                    ....*....|....*....|....*....|..
gi 1399236828   293 GHVETIFDCKFKPDDpNVLATASFDGTIKVWD 324
Cdd:smart00320   10 GHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 456-553 1.91e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.65  E-value: 1.91e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  456 SSNQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISGSWDYT 535
Cdd:PTZ00421   113 NISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLD-GSLLCTTSKDKK 191

                           90
                   ....*....|....*...
gi 1399236828  536 IKVWDTRGGVCLDTVYDH 553
Cdd:PTZ00421   192 LNIIDPRDGTIVSSVEAH 209
WD40 pfam00400
WD domain, G-beta repeat;
293-324 2.89e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 2.89e-04
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1399236828  293 GHVETIFDCKFKPDDpNVLATASFDGTIKVWD 324
Cdd:pfam00400    9 GHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
544-583 3.16e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 39.25  E-value: 3.16e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1399236828  544 GVCLDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWS 583
Cdd:pfam00400    1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 544-583 3.98e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.83  E-value: 3.98e-04
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1399236828   544 GVCLDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWS 583
Cdd:smart00320    2 GELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 456-581 4.50e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.11  E-value: 4.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  456 SSNQPLKVfsGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVST-------LNGHTAPVRGLMWNTEIPYLLI 528
Cdd:PTZ00421    65 ASNPPILL--GQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNisdpivhLQGHTKKVGIVSFHPSAMNVLA 142

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1399236828  529 SGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHpSRPFTMASCSRDSTVRL 581
Cdd:PTZ00421   143 SAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWN-LDGSLLCTTSKDKKLNI 194
PTZ00421 PTZ00421
coronin; Provisional
 293-380 1.51e-03

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.57  E-value: 1.51e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1399236828  293 GHVETIFDCKFKPDDPNVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSW-APGDLNCiagATSRNGAF-IWDIQK 370
Cdd:PTZ00421   123 GHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWnLDGSLLC---TTSKDKKLnIIDPRD 199

                           90
                   ....*....|
gi 1399236828  371 GKIIQRFNEH 380
Cdd:PTZ00421   200 GTIVSSVEAH 209
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 413-451 1.55e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.29  E-value: 1.55e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|
gi 1399236828   413 DGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVF 451
Cdd:smart00320    1 SGELLKTLKgHTGPVTSVAFSPDGK-YLASGSDDGTIKLW 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 516-584 2.40e-03

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.00  E-value: 2.40e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1399236828  516 GLMWNTEIPYLLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSL 584
Cdd:PLN00181   537 GICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSI 605
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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