IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to certain chemicals. NFkappaB blocking cell apoptosis in several cell types, gives it an important role in cell proliferation and differentiation.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354058 144 LKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGP-----GWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRV 218
Cdd:cd01177     1 LKICRLDKTSGSVKGGDEVYLLCDKVQKEDIQVRFFEEdeeetVWEAFGDFSQTDVHRQYAIVFRTPPYHDPDITEPVKV 80

                          90       100
                  ....*....|....*....|..
gi 1433354058 219 SMQLRRPSDRELSEPMEFQYLP 240
Cdd:cd01177    81 KIQLKRPSDGERSESVPFTYVP 102

large tegument protein UL36; Provisional

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354058  205 PPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFNGPTE-PRPPTRRIAV 283
Cdd:PHA03247  2613 PPSPLPPDTHAPDPPPPSPSPAANEPDPHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQrPRRRAARPTV 2692

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354058  284 -PTRNSTSVPKPAPQPYTFPASLStinfdefSPMLLPSGQISNQALALAPSSAPvlAQTMVPSSAMVPLAQPPAPAPVLT 362
Cdd:PHA03247  2693 gSLTSLADPPPPPPTPEPAPHALV-------SATPLPPGPAAARQASPALPAAP--APPAVPAGPATPGGPARPARPPTT 2763

                          170       180       190       200       210       220       230       240
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354058  363 PGPPQS------LSAPVPKSTQAGEGTLSEALlhlqfdadedlgALLGNSTDPGVFTDLASVDNSefqqllnqGVSMSHS 436
Cdd:PHA03247  2764 AGPPAPappaapAAGPPRRLTRPAVASLSESR------------ESLPSPWDPADPPAAVLAPAA--------ALPPAAS 2823

                          250       260       270
                   ....*....|....*....|....*....|....*
gi 1433354058  437 TAEPMlmeyPEAITRLVTGSQRPPDPAPTPLGTSG 471
Cdd:PHA03247  2824 PAGPL----PPPTSAQPTAPPPPPGPPPPSLPLGG 2854

IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to certain chemicals. NFkappaB blocking cell apoptosis in several cell types, gives it an important role in cell proliferation and differentiation.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354058 144 LKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGP-----GWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRV 218
Cdd:cd01177     1 LKICRLDKTSGSVKGGDEVYLLCDKVQKEDIQVRFFEEdeeetVWEAFGDFSQTDVHRQYAIVFRTPPYHDPDITEPVKV 80

                          90       100
                  ....*....|....*....|..
gi 1433354058 219 SMQLRRPSDRELSEPMEFQYLP 240
Cdd:cd01177    81 KIQLKRPSDGERSESVPFTYVP 102

N-terminal sub-domain of the Rel homology domain (RHD) of RelA; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD domain of the RelA family of transcription factors, categorized as a class II member of the NF-kappa B family. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). RelA (also called p65) forms heterodimers with NF-kappa B1 (p50) and B2 (p52). RelA also forms homodimers.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1433354058  93 VPIEEQRGDYDLNAVRLCFQVTVRDPAGRPLLLTPVLSHPIFDNR 137
Cdd:cd07885   125 VPIEEQRADYDLNAVRLCFQVTVRDPSGRLLPLPPVLSQPIYDNR 169

Rel homology DNA-binding domain; Proteins containing the Rel homology domain (RHD) are eukaryotic transcription factors. The RHD is composed of two structural domains. This is the N-terminal DNA-binding domain that is similar to that found in P53. The C-terminal domain has an immunoglobulin-like fold (See pfam16179) that functions as a dimerization domain.

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1433354058  96 EEQRGDYDLNAVRLCFQVTVRDPAGR-PLLLTPVLSHPIFDN 136
Cdd:pfam00554 128 LRQIKDMDLNVVRLCFQAFLPDTRGNfTTPLPPVVSNPIYDK 169

IPT domain of the transcription factor NFkappaB and related transcription factors. NFkappaB is considered a central regulator of stress responses, activated by different stressful conditions, including physical stress, oxidative stress, and exposure to certain chemicals. NFkappaB blocking cell apoptosis in several cell types, gives it an important role in cell proliferation and differentiation.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354058 144 LKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGP-----GWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRV 218
Cdd:cd01177     1 LKICRLDKTSGSVKGGDEVYLLCDKVQKEDIQVRFFEEdeeetVWEAFGDFSQTDVHRQYAIVFRTPPYHDPDITEPVKV 80

                          90       100
                  ....*....|....*....|..
gi 1433354058 219 SMQLRRPSDRELSEPMEFQYLP 240
Cdd:cd01177    81 KIQLKRPSDGERSESVPFTYVP 102

IPT domain of eukaryotic transcription factors NF-kappaB/Rel, nuclear factor of activated Tcells (NFAT), and recombination signal J-kappa binding protein (RBP-Jkappa). The IPT domains in these proteins are involved in DNA binding. Most NF-kappaB/Rel proteins form homo- and heterodimers, while NFAT proteins are largely monomeric (with TonEBP being an exception). While the majority of sequence-specific DNA binding elements are found in the N-terminal domain, several are found in the IPT domain in loops adjacent to, and including, the linker region.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354058 144 LKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYF-----TGPGWEARGSFSQADVHrQVAIVFRTPPYADPSLQAPVRV 218
Cdd:cd00602     1 LPICRVSSLSGSVNGGDEVFLLCDKVNKPDIKVWFgekgpGETVWEAEAMFRQEDVR-QVAIVFKTPPYHNKWITRPVQV 79

                          90       100
                  ....*....|....*....|..
gi 1433354058 219 SMQLRRPSDRELSEPMEFQYLP 240
Cdd:cd00602    80 PIQLVRPDDRKRSEPLTFTYTP 101

ig-like, plexins, transcription factors;

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354058  143 ELKICRVNRNSGSCLGGDEIfLLCDKVQKEDIEVYFTGPGWEARGSFSQAdvhRQVAIVFRTPPYADPSLQAPVRVSMQL 222
Cdd:smart00429   1 DPVITRISPTSGPVSGGTEI-TLCGKNLKSISVVFVEVGVGEAPCTFSPS---SSTAIVCKTPPYHNIPGSVPVRTVGLR 76

                           90
                   ....*....|....*..
gi 1433354058  223 RRPSdreLSEPMEFQYL 239
Cdd:smart00429  77 NGGV---PSSPQPFTYV 90

N-terminal sub-domain of the Rel homology domain (RHD); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal sub-domain, which may be distantly related to the DNA-binding domain found in P53. The C-terminal sub-domain has an immunoglobulin-like fold and serves as a dimerization module that also binds DNA (see cd00102). The RHD is found in NF-kappa B, nuclear factor of activated T-cells (NFAT), the tonicity-responsive enhancer binding protein (TonEBP), and the arthropod proteins Dorsal and Relish (Rel).

                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*
gi 1433354058  94 PIEEQRGDYDLNAVRLCFQVTVRDPAG-RPLLLTPVLSHPIFDNR 137
Cdd:cd07827   130 GPEGNASDIDLNRVRLCFQAFIEDSDGgFTLPLPPVLSNPIYDKK 174

N-terminal sub-domain of the Rel homology domain (RHD) of the reticuloendotheliosis viral oncogene homolog B (RelB) protein; Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the RelB family of transcription factors, categorized as class II NF-kappa B family members. In class II NF-kappa Bs, the RHD domain co-occurs with a C-terminal transactivation domain (TAD). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and Rel). RelB, is unable to homodimerize but is a potent transactivator in a heterodimer with NF-kappa B1 (p50) or B2 (p52). It is involved in the regulation of genes that play roles in inflammatory processes and the immune response.

                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1433354058 101 DYDLNAVRLCFQVTVRDPAGRPLLLTPVLSHPIFDNR 137
Cdd:cd07886   136 EVDMNVVRLCFQASYRDDDGRKDCLSPVLSEPIYDKK 172

IPT domain of the NFAT family of transcription factors. NFAT transcription complexes are a target of calcineurin, a calcium dependent phosphatase, and activate genes mainly involved in cell-cell-interaction.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1433354058 146 ICRVNRNSGSCLGGDEIFLLCDKVQKeDIEVYF------TGPGWEARGSFSQADVHrQVAIVFRTPPYADPSLQAPVRVS 219
Cdd:cd01178     4 IEKKSLNSCSVNGGEELFLTGKNFLK-DSKVVFqekgqdGEAQWEAEATIDKEKSH-QNHLVVEVPPYHNKHVAAPVQVQ 81

                          90       100
                  ....*....|....*....|.
gi 1433354058 220 MQLRRpSDRELSEPMEFQYLP 240
Cdd:cd01178    82 FYVVN-GKRKRSQPQTFTYTP 101

N-terminal sub-domain of the Rel homology domain (RHD) of nuclear factor of kappa light polypeptide gene enhancer in B-cells (NF-kappa B); Proteins containing the Rel homology domain (RHD) are metazoan transcription factors. The RHD is composed of two structural sub-domains; this model characterizes the N-terminal RHD sub-domain of the NF-kappa B1 and B2 families of transcription factors, also referred to as class I members of the NF-kappa B family. In class I NF-kappa Bs, the RHD domain co-occurs with C-terminal ankyrin repeats. Family members include NF-kappa B1 and NF-kappa B2. NF-kappa B1 is commonly referred to as p105 or p50 (proteolytically processed form), while NF-kappa B2 is called p100 or p52 (proteolytically processed form). NF-kappa B proteins are part of a protein complex that acts as a transcription factor, which is responsible for regulating a host of cellular responses to a variety of stimuli. This complex tightly regulates the expression of a large number of genes, and is involved in processes such as adaptive and innate immunity, stress response, inflammation, cell adhesion, proliferation and apoptosis. The cytosolic NF-kappa B complex is activated via phosphorylation of the ankyrin-repeat containing inhibitory protein I-kappa B, which dissociates from the complex and exposes the nuclear localization signal of the heterodimer (NF-kappa B and REL). p105 and p100 may also act as I-kappa Bs due to their C-terminal ankyrin repeats.

                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1433354058  77 GMATMRLTSAQTAVSIVPIEEQRGDYDLNAVRLCFQVTVRDPAGR-PLLLTPVLSHPIFDNR 137
Cdd:cd07883   136 GGGDRQLTDEEQAEIRQKAKQQAKSMDLSVVRLCFQAFLPDSNGSfTRPLKPVISDAIYDSK 197