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Conserved domains on  [gi|1533911199|ref|NP_001354552|]
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rho guanine nucleotide exchange factor 33 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
RhoGEF super family cl47571
RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called ...
269-436 1.41e-14

RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.


The actual alignment was detected with superfamily member pfam00621:

Pssm-ID: 459876 [Multi-domain]  Cd Length: 176  Bit Score: 72.33  E-value: 1.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533911199 269 VALELLESERKYVINISLILKIkatFQGSDGK--RNSKE--RSLFpGSLRYLVQQHLDLLhaLQERVLKWPRQGVLGDLF 344
Cdd:pfam00621   1 VIKELLQTERSYVRDLEILVEV---FLPPNSKplSESEEeiKTIF-SNIEEIYELHRQLL--LEELLKEWISIQRIGDIF 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533911199 345 LKLTNdennFLDYYVAYLRDLPECISLVHvvvlkegDEEIKSDIYTLFFHI-------------------VQRIPEYLIH 405
Cdd:pfam00621  75 LKFAP----GFKVYSTYCSNYPKALKLLK-------KLLKKNPKFRAFLEEleanpecrgldlnsflikpVQRIPRYPLL 143
                         170       180       190
                  ....*....|....*....|....*....|.
gi 1533911199 406 LQNVLKFTEQEHPDYYLLLVCVQRLRVFISH 436
Cdd:pfam00621 144 LKELLKHTPPDHPDYEDLKKALEAIKEVAKQ 174
PRK12323 super family cl46901
DNA polymerase III subunit gamma/tau;
463-688 3.69e-04

DNA polymerase III subunit gamma/tau;


The actual alignment was detected with superfamily member PRK12323:

Pssm-ID: 481241 [Multi-domain]  Cd Length: 700  Bit Score: 44.10  E-value: 3.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533911199 463 LYKGLASQCANAGQDASPTAGPEAVRDTGIHSEELLQPYPSAPSSGPAITHLMPPVKKSQQQQSLMES-MQPGKPSDWEL 541
Cdd:PRK12323  357 LLRMLAFRPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPArRSPAPEALAAA 436
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533911199 542 EGRKHERPESLLAPTQfcaaeqdvKALAGPLQAIPemdfeSSPAEPLGNVERSLRAPAELLPDA-RGFVPAAYEEFEYGG 620
Cdd:PRK12323  437 RQASARGPGGAPAPAP--------APAAAPAAAAR-----PAAAGPRPVAAAAAAAPARAAPAAaPAPADDDPPPWEELP 503
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1533911199 621 EIFALPAPYDEEPFQAPALFENCS-PASSESSLDICFLRPVSFAMEAERPEHPLQPLPkSATSPAGSSS 688
Cdd:PRK12323  504 PEFASPAPAQPDAAPAGWVAESIPdPATADPDDAFETLAPAPAAAPAPRAAAATEPVV-APRPPRASAS 571
ZapB super family cl43780
Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome ...
54-120 6.59e-03

Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome partitioning];


The actual alignment was detected with superfamily member COG3074:

Pssm-ID: 442308 [Multi-domain]  Cd Length: 79  Bit Score: 36.49  E-value: 6.59e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1533911199  54 LEEKVKScrcsMEEKVTEMKNSLNYFKEELSNAMSMIQAITSKQEEMQQKIEQLQQEKRRESRKVKA 120
Cdd:COG3074     9 LEAKVQQ----AVDTIELLQMEVEELKEKNEELEQENEELQSENEELQSENEQLKTENAEWQERIRS 71
 
Name Accession Description Interval E-value
RhoGEF pfam00621
RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called ...
269-436 1.41e-14

RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.


Pssm-ID: 459876 [Multi-domain]  Cd Length: 176  Bit Score: 72.33  E-value: 1.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533911199 269 VALELLESERKYVINISLILKIkatFQGSDGK--RNSKE--RSLFpGSLRYLVQQHLDLLhaLQERVLKWPRQGVLGDLF 344
Cdd:pfam00621   1 VIKELLQTERSYVRDLEILVEV---FLPPNSKplSESEEeiKTIF-SNIEEIYELHRQLL--LEELLKEWISIQRIGDIF 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533911199 345 LKLTNdennFLDYYVAYLRDLPECISLVHvvvlkegDEEIKSDIYTLFFHI-------------------VQRIPEYLIH 405
Cdd:pfam00621  75 LKFAP----GFKVYSTYCSNYPKALKLLK-------KLLKKNPKFRAFLEEleanpecrgldlnsflikpVQRIPRYPLL 143
                         170       180       190
                  ....*....|....*....|....*....|.
gi 1533911199 406 LQNVLKFTEQEHPDYYLLLVCVQRLRVFISH 436
Cdd:pfam00621 144 LKELLKHTPPDHPDYEDLKKALEAIKEVAKQ 174
RhoGEF cd00160
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous ...
266-436 5.52e-11

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.


Pssm-ID: 238091 [Multi-domain]  Cd Length: 181  Bit Score: 62.32  E-value: 5.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533911199 266 RQTVALELLESERKYVINISLILKIKATFQGSDGKRNSKE--RSLFpGSLRYLVQQHLDLLHALQERVLKWPRQGV-LGD 342
Cdd:cd00160     1 RQEVIKELLQTERNYVRDLKLLVEVFLKPLDKELLPLSPEevELLF-GNIEEIYEFHRIFLKSLEERVEEWDKSGPrIGD 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533911199 343 LFLKLtndeNNFLDYYVAYLRDLPECISL----------VHVVVLKEGDEEIKSDIYTLFFHIVQRIPEYLIHLQNVLKF 412
Cdd:cd00160    80 VFLKL----APFFKIYSEYCSNHPDALELlkklkkfnkfFQEFLEKAESECGRLKLESLLLKPVQRLTKYPLLLKELLKH 155
                         170       180
                  ....*....|....*....|....
gi 1533911199 413 TEQEHPDYYLLLVCVQRLRVFISH 436
Cdd:cd00160   156 TPDGHEDREDLKKALEAIKEVASQ 179
RhoGEF smart00325
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Guanine nucleotide exchange ...
269-445 1.71e-10

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains. Improved coverage.


Pssm-ID: 214619 [Multi-domain]  Cd Length: 180  Bit Score: 60.78  E-value: 1.71e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533911199  269 VALELLESERKYVINISLILKI-KATFQGSDGK-RNSKERSLFpGSLRYLVQQHLDLLHALQERVLKWPRQGV-LGDLFL 345
Cdd:smart00325   1 VLKELLQTERNYVRDLKLLVEVfLKPLKKELKLlSPNELETLF-GNIEEIYEFHRDFLDELEERIEEWDDSVErIGDVFL 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533911199  346 KLtndeNNFLDYYVAYLRDLPECISLVH--------VVVLKEGDEEIKSDIYTLFFHI---VQRIPEYLIHLQNVLKFTE 414
Cdd:smart00325  80 KL----EEFFKIYSEYCSNHPDALELLKklkknprfQKFLKEIESSPQCRRLTLESLLlkpVQRLTKYPLLLKELLKHTP 155
                          170       180       190
                   ....*....|....*....|....*....|.
gi 1533911199  415 QEHPDYYLLLVCVQRLRvfishyTLLFQCNE 445
Cdd:smart00325 156 EDHEDREDLKKALKAIK------ELANQVNE 180
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
463-688 3.69e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.10  E-value: 3.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533911199 463 LYKGLASQCANAGQDASPTAGPEAVRDTGIHSEELLQPYPSAPSSGPAITHLMPPVKKSQQQQSLMES-MQPGKPSDWEL 541
Cdd:PRK12323  357 LLRMLAFRPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPArRSPAPEALAAA 436
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533911199 542 EGRKHERPESLLAPTQfcaaeqdvKALAGPLQAIPemdfeSSPAEPLGNVERSLRAPAELLPDA-RGFVPAAYEEFEYGG 620
Cdd:PRK12323  437 RQASARGPGGAPAPAP--------APAAAPAAAAR-----PAAAGPRPVAAAAAAAPARAAPAAaPAPADDDPPPWEELP 503
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1533911199 621 EIFALPAPYDEEPFQAPALFENCS-PASSESSLDICFLRPVSFAMEAERPEHPLQPLPkSATSPAGSSS 688
Cdd:PRK12323  504 PEFASPAPAQPDAAPAGWVAESIPdPATADPDDAFETLAPAPAAAPAPRAAAATEPVV-APRPPRASAS 571
ZapB COG3074
Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome ...
54-120 6.59e-03

Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442308 [Multi-domain]  Cd Length: 79  Bit Score: 36.49  E-value: 6.59e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1533911199  54 LEEKVKScrcsMEEKVTEMKNSLNYFKEELSNAMSMIQAITSKQEEMQQKIEQLQQEKRRESRKVKA 120
Cdd:COG3074     9 LEAKVQQ----AVDTIELLQMEVEELKEKNEELEQENEELQSENEELQSENEQLKTENAEWQERIRS 71
 
Name Accession Description Interval E-value
RhoGEF pfam00621
RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called ...
269-436 1.41e-14

RhoGEF domain; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that pfam00169 domains invariably occur C-terminal to RhoGEF/DH domains.


Pssm-ID: 459876 [Multi-domain]  Cd Length: 176  Bit Score: 72.33  E-value: 1.41e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533911199 269 VALELLESERKYVINISLILKIkatFQGSDGK--RNSKE--RSLFpGSLRYLVQQHLDLLhaLQERVLKWPRQGVLGDLF 344
Cdd:pfam00621   1 VIKELLQTERSYVRDLEILVEV---FLPPNSKplSESEEeiKTIF-SNIEEIYELHRQLL--LEELLKEWISIQRIGDIF 74
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533911199 345 LKLTNdennFLDYYVAYLRDLPECISLVHvvvlkegDEEIKSDIYTLFFHI-------------------VQRIPEYLIH 405
Cdd:pfam00621  75 LKFAP----GFKVYSTYCSNYPKALKLLK-------KLLKKNPKFRAFLEEleanpecrgldlnsflikpVQRIPRYPLL 143
                         170       180       190
                  ....*....|....*....|....*....|.
gi 1533911199 406 LQNVLKFTEQEHPDYYLLLVCVQRLRVFISH 436
Cdd:pfam00621 144 LKELLKHTPPDHPDYEDLKKALEAIKEVAKQ 174
RhoGEF cd00160
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous ...
266-436 5.52e-11

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.


Pssm-ID: 238091 [Multi-domain]  Cd Length: 181  Bit Score: 62.32  E-value: 5.52e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533911199 266 RQTVALELLESERKYVINISLILKIKATFQGSDGKRNSKE--RSLFpGSLRYLVQQHLDLLHALQERVLKWPRQGV-LGD 342
Cdd:cd00160     1 RQEVIKELLQTERNYVRDLKLLVEVFLKPLDKELLPLSPEevELLF-GNIEEIYEFHRIFLKSLEERVEEWDKSGPrIGD 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533911199 343 LFLKLtndeNNFLDYYVAYLRDLPECISL----------VHVVVLKEGDEEIKSDIYTLFFHIVQRIPEYLIHLQNVLKF 412
Cdd:cd00160    80 VFLKL----APFFKIYSEYCSNHPDALELlkklkkfnkfFQEFLEKAESECGRLKLESLLLKPVQRLTKYPLLLKELLKH 155
                         170       180
                  ....*....|....*....|....
gi 1533911199 413 TEQEHPDYYLLLVCVQRLRVFISH 436
Cdd:cd00160   156 TPDGHEDREDLKKALEAIKEVASQ 179
RhoGEF smart00325
Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Guanine nucleotide exchange ...
269-445 1.71e-10

Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains. Improved coverage.


Pssm-ID: 214619 [Multi-domain]  Cd Length: 180  Bit Score: 60.78  E-value: 1.71e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533911199  269 VALELLESERKYVINISLILKI-KATFQGSDGK-RNSKERSLFpGSLRYLVQQHLDLLHALQERVLKWPRQGV-LGDLFL 345
Cdd:smart00325   1 VLKELLQTERNYVRDLKLLVEVfLKPLKKELKLlSPNELETLF-GNIEEIYEFHRDFLDELEERIEEWDDSVErIGDVFL 79
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533911199  346 KLtndeNNFLDYYVAYLRDLPECISLVH--------VVVLKEGDEEIKSDIYTLFFHI---VQRIPEYLIHLQNVLKFTE 414
Cdd:smart00325  80 KL----EEFFKIYSEYCSNHPDALELLKklkknprfQKFLKEIESSPQCRRLTLESLLlkpVQRLTKYPLLLKELLKHTP 155
                          170       180       190
                   ....*....|....*....|....*....|.
gi 1533911199  415 QEHPDYYLLLVCVQRLRvfishyTLLFQCNE 445
Cdd:smart00325 156 EDHEDREDLKKALKAIK------ELANQVNE 180
PRK12323 PRK12323
DNA polymerase III subunit gamma/tau;
463-688 3.69e-04

DNA polymerase III subunit gamma/tau;


Pssm-ID: 237057 [Multi-domain]  Cd Length: 700  Bit Score: 44.10  E-value: 3.69e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533911199 463 LYKGLASQCANAGQDASPTAGPEAVRDTGIHSEELLQPYPSAPSSGPAITHLMPPVKKSQQQQSLMES-MQPGKPSDWEL 541
Cdd:PRK12323  357 LLRMLAFRPGQSGGGAGPATAAAAPVAQPAPAAAAPAAAAPAPAAPPAAPAAAPAAAAAARAVAAAPArRSPAPEALAAA 436
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1533911199 542 EGRKHERPESLLAPTQfcaaeqdvKALAGPLQAIPemdfeSSPAEPLGNVERSLRAPAELLPDA-RGFVPAAYEEFEYGG 620
Cdd:PRK12323  437 RQASARGPGGAPAPAP--------APAAAPAAAAR-----PAAAGPRPVAAAAAAAPARAAPAAaPAPADDDPPPWEELP 503
                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1533911199 621 EIFALPAPYDEEPFQAPALFENCS-PASSESSLDICFLRPVSFAMEAERPEHPLQPLPkSATSPAGSSS 688
Cdd:PRK12323  504 PEFASPAPAQPDAAPAGWVAESIPdPATADPDDAFETLAPAPAAAPAPRAAAATEPVV-APRPPRASAS 571
ZapB COG3074
Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome ...
54-120 6.59e-03

Cell division protein ZapB, interacts with FtsZ [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 442308 [Multi-domain]  Cd Length: 79  Bit Score: 36.49  E-value: 6.59e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1533911199  54 LEEKVKScrcsMEEKVTEMKNSLNYFKEELSNAMSMIQAITSKQEEMQQKIEQLQQEKRRESRKVKA 120
Cdd:COG3074     9 LEAKVQQ----AVDTIELLQMEVEELKEKNEELEQENEELQSENEELQSENEQLKTENAEWQERIRS 71
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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