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Conserved domains on  [gi|1571052963|ref|NP_001355333|]
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zinc finger protein 878 isoform 1 [Mus musculus]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 26-66 3.89e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.99  E-value: 3.89e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1571052963  26 VTFDDVHVDFTSEEWALLDPSQKSLYKDVMLETYWNLTAIG 66
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
125-484 6.79e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.33  E-value: 6.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 125 YECNPCGKAFAYHCHLRIHKRIHTAEKLYKC--IQCGKAFSEHNTLQKHKRTHSEEKPYECNQCG---KAFAHHNILRNH 199
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsNSKASSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 200 erTHIGEKPYQCNECDKAFSQHYYLRIHKRIHTGEKPYECNQC----------------------DKAFACLSYLRVHGR 257
Cdd:COG5048   114 --SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 258 THTGEKPYKCNQCGKVFASHSNLKRHKRTHTGEKPYECNQCGKAFSDHHTLRIH------ERAHTGEKPFECNQCGKTFK 331
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 332 LHSQLRIHKRTHTG-EKPHECNQCGKTFACPSSFQKHKR--IHTGE--KPYEC--NQCLKAFAYHSRLRKHERTHTGEKP 404
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 405 FRC--NQCGKIFSQSN-----SLQVHKRTHTGEKPYECD--RCGKAFPYDSSLRVHKRTHTGVKPYECN--QCGKAFGYN 473
Cdd:COG5048   352 AKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                         410
                  ....*....|.
gi 1571052963 474 SHLQRHERTHT 484
Cdd:COG5048   432 YNLIPHKKIHT 442
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 26-66 3.89e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.99  E-value: 3.89e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1571052963  26 VTFDDVHVDFTSEEWALLDPSQKSLYKDVMLETYWNLTAIG 66
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
26-67 1.37e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.56  E-value: 1.37e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1571052963   26 VTFDDVHVDFTSEEWALLDPSQKSLYKDVMLETYWNLTAIGY 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 26-63 1.61e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 75.66  E-value: 1.61e-17
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1571052963  26 VTFDDVHVDFTSEEWALLDPSQKSLYKDVMLETYWNLT 63
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
125-484 6.79e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.33  E-value: 6.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 125 YECNPCGKAFAYHCHLRIHKRIHTAEKLYKC--IQCGKAFSEHNTLQKHKRTHSEEKPYECNQCG---KAFAHHNILRNH 199
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsNSKASSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 200 erTHIGEKPYQCNECDKAFSQHYYLRIHKRIHTGEKPYECNQC----------------------DKAFACLSYLRVHGR 257
Cdd:COG5048   114 --SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 258 THTGEKPYKCNQCGKVFASHSNLKRHKRTHTGEKPYECNQCGKAFSDHHTLRIH------ERAHTGEKPFECNQCGKTFK 331
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 332 LHSQLRIHKRTHTG-EKPHECNQCGKTFACPSSFQKHKR--IHTGE--KPYEC--NQCLKAFAYHSRLRKHERTHTGEKP 404
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 405 FRC--NQCGKIFSQSN-----SLQVHKRTHTGEKPYECD--RCGKAFPYDSSLRVHKRTHTGVKPYECN--QCGKAFGYN 473
Cdd:COG5048   352 AKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                         410
                  ....*....|.
gi 1571052963 474 SHLQRHERTHT 484
Cdd:COG5048   432 YNLIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
279-303 1.09e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.09e-04
                          10        20
                  ....*....|....*....|....*
gi 1571052963 279 NLKRHKRTHTGEKPYECNQCGKAFS 303
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 26-66 3.89e-21

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 85.99  E-value: 3.89e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 1571052963  26 VTFDDVHVDFTSEEWALLDPSQKSLYKDVMLETYWNLTAIG 66
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
26-67 1.37e-18

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 79.56  E-value: 1.37e-18
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1571052963   26 VTFDDVHVDFTSEEWALLDPSQKSLYKDVMLETYWNLTAIGY 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGF 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 26-63 1.61e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 75.66  E-value: 1.61e-17
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1571052963  26 VTFDDVHVDFTSEEWALLDPSQKSLYKDVMLETYWNLT 63
Cdd:cd07765     1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLV 38
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
125-484 6.79e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.33  E-value: 6.79e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 125 YECNPCGKAFAYHCHLRIHKRIHTAEKLYKC--IQCGKAFSEHNTLQKHKRTHSEEKPYECNQCG---KAFAHHNILRNH 199
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLplsNSKASSSSLSSS 113

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 200 erTHIGEKPYQCNECDKAFSQHYYLRIHKRIHTGEKPYECNQC----------------------DKAFACLSYLRVHGR 257
Cdd:COG5048   114 --SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 258 THTGEKPYKCNQCGKVFASHSNLKRHKRTHTGEKPYECNQCGKAFSDHHTLRIH------ERAHTGEKPFECNQCGKTFK 331
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 332 LHSQLRIHKRTHTG-EKPHECNQCGKTFACPSSFQKHKR--IHTGE--KPYEC--NQCLKAFAYHSRLRKHERTHTGEKP 404
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 405 FRC--NQCGKIFSQSN-----SLQVHKRTHTGEKPYECD--RCGKAFPYDSSLRVHKRTHTGVKPYECN--QCGKAFGYN 473
Cdd:COG5048   352 AKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRH 431

                         410
                  ....*....|.
gi 1571052963 474 SHLQRHERTHT 484
Cdd:COG5048   432 YNLIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
165-463 2.46e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.32  E-value: 2.46e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 165 HNTLQKHKRTHSEE----KPYECNQCGKAFAHHNILRNHERTHIGEKPYQCN--ECDKAFSQHYYLRIHKRIHTGEKPYE 238
Cdd:COG5048    14 SVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDL 93

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 239 CNQ--CDKAFACLSYLRVHGRTHTgEKPYKCNQCGKVFASHSNLKRHKRTHTGEKPYECNQCGKAF-------------- 302
Cdd:COG5048    94 NSKslPLSNSKASSSSLSSSSSNS-NDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqsnslhpplp 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 303 --------SDHHTLRIHERAHTGEKPFECNQCGKTF-KLHSQLRIHKRTH--TGEKPHECNQCG-KTFACPSSFQKHKRI 370
Cdd:COG5048   173 anslskdpSSNLSLLISSNVSTSIPSSSENSPLSSSySIPSSSSDQNLENssSSLPLTTNSQLSpKSLLSQSPSSLSSSD 252

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 371 HTGEKP--YECNQCLKAFAYHSRLRKHERTHTG-EKPFRCNQCGKIFSQSNSLQVHKRT--HTGE--KPYECD--RCGKA 441
Cdd:COG5048   253 SSSSASesPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKL 332

                         330       340
                  ....*....|....*....|..
gi 1571052963 442 FPYDSSLRVHKRTHTGVKPYEC 463
Cdd:COG5048   333 FSRNDALKRHILLHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
118-368 3.76e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.94  E-value: 3.76e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 118 IHTGKKFYECNPCGKAFAYHcHLRIHKRIHTAEKLYKCIQCGKAFSEHNTLQKHKRTHSEEKP------YECNQCGKAFA 191
Cdd:COG5048   193 STSIPSSSENSPLSSSYSIP-SSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSssasesPRSSLPTASSQ 271

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 192 HHNILRNHERTHIG-EKPYQCNECDKAFSQHYYLRIHKR--IHTGE--KPYEC--NQCDKAFACLSYLRVHGRTHTGEKP 264
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 265 YKC--NQCGKVFASHSNLKRHKRTH-----TGEKPYEC--NQCGKAFSDHHTLRIHERAHTGEKP--FECNQCGKTFKLH 333
Cdd:COG5048   352 AKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRH 431

                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1571052963 334 SQLRIHKRTHTGEKPHECNQCGKTFACPSSFQKHK 368
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
272-452 4.32e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 58.55  E-value: 4.32e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 272 KVFASHSNLKRHKRTHTG-EKPYECNQCGKAFSDHHTLRIHERA--HTGE--KPFEC--NQCGKTFKLHSQLRIHKRTHT 344
Cdd:COG5048   268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 345 GEKPHEC--NQCGKTF------ACPSSFQKHKRIHTgEKPYEC--NQCLKAFAYHSRLRKHERTHTGEKP--FRCNQCGK 412
Cdd:COG5048   348 SISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSK 426

                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1571052963 413 IFSQSNSLQVHKRTHTGEKPYECDRCGKAFPYDSSLRVHK 452
Cdd:COG5048   427 SFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
95-255 5.22e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 5.22e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963  95 KPYEEIKYGEAFAHHGSLQIHKR--IHTGKKFYEC----NPCGKAFAYHCHLRIHKRIHTAEKLYKCIQC-------GKA 161
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFscpySLCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLL 367

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 162 FSEHNTLQKHKRTHSEEKPYEC--NQCGKAFAHHNILRNHERTHIGEKPYQCN--ECDKAFSQHYYLRIHKRIHTGEKPY 237
Cdd:COG5048   368 NNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                         170
                  ....*....|....*...
gi 1571052963 238 ECNQCDKAFACLSYLRVH 255
Cdd:COG5048   448 LCSILKSFRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
263-489 1.32e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 47.38  E-value: 1.32e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 263 KPYKCNQCGKVFASHSNLKRHKRTHTGEKPYECNQ--CGKAFSDHHTLRIHERAHTGEKPFECNQCGKT----------- 329
Cdd:COG5048    32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLsnskassssls 111

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 330 -----------------------------------------------------FKLHSQLR---------------IHKR 341
Cdd:COG5048   112 ssssnsndnnllsshslppssrdpqlpdllsisnlrnnplpgnnsssvntpqsNSLHPPLPanslskdpssnlsllISSN 191

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 342 THTGEKPHECNQCGKTFACPSSFQKHKRIHTGEKPYECNQCLKAFAYHSRLR------KHERTHTGEKPFRCNQCGKIFS 415
Cdd:COG5048   192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQspsslsSSDSSSSASESPRSSLPTASSQ 271

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 416 QSNSLQVHKRTHTG-EKPYECDRCGKAFPYDSSLRVHKRT--HTG--VKPYEC--NQCGKAFGYNSHLQRHERTHTGEKP 488
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGesLKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351


                  .
gi 1571052963 489 Y 489
Cdd:COG5048   352 A 352
zf-H2C2_2 pfam13465
Zinc-finger double domain;
279-303 1.09e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.09e-04
                          10        20
                  ....*....|....*....|....*
gi 1571052963 279 NLKRHKRTHTGEKPYECNQCGKAFS 303
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
223-248 6.99e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.97  E-value: 6.99e-04
                          10        20
                  ....*....|....*....|....*.
gi 1571052963 223 YLRIHKRIHTGEKPYECNQCDKAFAC 248
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
196-220 1.59e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.59e-03
                          10        20
                  ....*....|....*....|....*
gi 1571052963 196 LRNHERTHIGEKPYQCNECDKAFSQ 220
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
336-360 1.72e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.72e-03
                          10        20
                  ....*....|....*....|....*
gi 1571052963 336 LRIHKRTHTGEKPHECNQCGKTFAC 360
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
391-416 2.20e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.20e-03
                          10        20
                  ....*....|....*....|....*.
gi 1571052963 391 RLRKHERTHTGEKPFRCNQCGKIFSQ 416
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
168-192 3.02e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.02e-03
                          10        20
                  ....*....|....*....|....*
gi 1571052963 168 LQKHKRTHSEEKPYECNQCGKAFAH 192
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 204-288 3.06e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.09  E-value: 3.06e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052963 204 IGEKPYQCN--ECDKAFSQHYYLRIHKRI-HTGEKPYECNQCDKafaclsylrvHGRTHTGEKPYKCNQCGKVFASHSNL 280
Cdd:COG5189   345 KDGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGL 414


                  ....*...
gi 1571052963 281 KRHkRTHT 288
Cdd:COG5189   415 KYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
447-470 3.39e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.39e-03
                          10        20
                  ....*....|....*....|....
gi 1571052963 447 SLRVHKRTHTGVKPYECNQCGKAF 470
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
363-388 4.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.09e-03
                          10        20
                  ....*....|....*....|....*.
gi 1571052963 363 SFQKHKRIHTGEKPYECNQCLKAFAY 388
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
419-442 4.09e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.09e-03
                          10        20
                  ....*....|....*....|....
gi 1571052963 419 SLQVHKRTHTGEKPYECDRCGKAF 442
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 265-287 7.94e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 33.81  E-value: 7.94e-03
                          10        20
                  ....*....|....*....|...
gi 1571052963 265 YKCNQCGKVFASHSNLKRHKRTH 287
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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