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Conserved domains on  [gi|1571052945|ref|NP_001355334|]
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zinc finger protein 878 isoform 3 [Mus musculus]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
71-430 1.31e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 1.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052945  71 YECNPCGKAFAYHCHLRIHKRIHTAEKLYKC--IQCGKAFSEHNTLQKHKRTHSEEKPYECNQCGKAFAHHNILRNHER- 147
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSs 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052945 148 THIGEKPYQCNECDKAFSQHYYLRIHKRIHTGEKPYECNQC----------------------DKAFACLSYLRVHGRTH 205
Cdd:COG5048   114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSNVS 193
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052945 206 TGEKPYKCNQCGKVFASHSNLKRHKRTHTGEKPYECNQCGKAFSDHHTLRIH------ERAHTGEKPFECNQCGKTFKLH 279
Cdd:COG5048   194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPTASSQSS 273
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052945 280 SQLRIHKRTHTG-EKPHECNQCGKTFACPSSFQKHKR--IHTGE--KPYEC--NQCLKAFAYHSRLRKHERTHTGEKPFR 352
Cdd:COG5048   274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAK 353
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052945 353 C--NQCGKIFSQSN-----SLQVHKRTHTGEKPYECD--RCGKAFPYDSSLRVHKRTHTGVKPYECN--QCGKAFGYNSH 421
Cdd:COG5048   354 EklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYN 433

                  ....*....
gi 1571052945 422 LQRHERTHT 430
Cdd:COG5048   434 LIPHKKIHT 442
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
71-430 1.31e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 1.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052945  71 YECNPCGKAFAYHCHLRIHKRIHTAEKLYKC--IQCGKAFSEHNTLQKHKRTHSEEKPYECNQCGKAFAHHNILRNHER- 147
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSs 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052945 148 THIGEKPYQCNECDKAFSQHYYLRIHKRIHTGEKPYECNQC----------------------DKAFACLSYLRVHGRTH 205
Cdd:COG5048   114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSNVS 193
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052945 206 TGEKPYKCNQCGKVFASHSNLKRHKRTHTGEKPYECNQCGKAFSDHHTLRIH------ERAHTGEKPFECNQCGKTFKLH 279
Cdd:COG5048   194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPTASSQSS 273
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052945 280 SQLRIHKRTHTG-EKPHECNQCGKTFACPSSFQKHKR--IHTGE--KPYEC--NQCLKAFAYHSRLRKHERTHTGEKPFR 352
Cdd:COG5048   274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAK 353
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052945 353 C--NQCGKIFSQSN-----SLQVHKRTHTGEKPYECD--RCGKAFPYDSSLRVHKRTHTGVKPYECN--QCGKAFGYNSH 421
Cdd:COG5048   354 EklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYN 433

                  ....*....
gi 1571052945 422 LQRHERTHT 430
Cdd:COG5048   434 LIPHKKIHT 442
zf-H2C2_2 pfam13465
Zinc-finger double domain;
225-249 2.50e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.50e-04
                          10        20
                  ....*....|....*....|....*
gi 1571052945 225 NLKRHKRTHTGEKPYECNQCGKAFS 249
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
71-430 1.31e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 59.71  E-value: 1.31e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052945  71 YECNPCGKAFAYHCHLRIHKRIHTAEKLYKC--IQCGKAFSEHNTLQKHKRTHSEEKPYECNQCGKAFAHHNILRNHER- 147
Cdd:COG5048    34 DSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSs 113
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052945 148 THIGEKPYQCNECDKAFSQHYYLRIHKRIHTGEKPYECNQC----------------------DKAFACLSYLRVHGRTH 205
Cdd:COG5048   114 SSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnsssvntpqsnslhpplpanslSKDPSSNLSLLISSNVS 193
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052945 206 TGEKPYKCNQCGKVFASHSNLKRHKRTHTGEKPYECNQCGKAFSDHHTLRIH------ERAHTGEKPFECNQCGKTFKLH 279
Cdd:COG5048   194 TSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPTASSQSS 273
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052945 280 SQLRIHKRTHTG-EKPHECNQCGKTFACPSSFQKHKR--IHTGE--KPYEC--NQCLKAFAYHSRLRKHERTHTGEKPFR 352
Cdd:COG5048   274 SPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAK 353
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052945 353 C--NQCGKIFSQSN-----SLQVHKRTHTGEKPYECD--RCGKAFPYDSSLRVHKRTHTGVKPYECN--QCGKAFGYNSH 421
Cdd:COG5048   354 EklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYN 433

                  ....*....
gi 1571052945 422 LQRHERTHT 430
Cdd:COG5048   434 LIPHKKIHT 442
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
218-398 3.87e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 3.87e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052945 218 KVFASHSNLKRHKRTHTG-EKPYECNQCGKAFSDHHTLRIHERA--HTGE--KPFEC--NQCGKTFKLHSQLRIHKRTHT 290
Cdd:COG5048   268 ASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHT 347
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052945 291 GEKPHEC--NQCGKTF------ACPSSFQKHKRIHTgEKPYEC--NQCLKAFAYHSRLRKHERTHTGEKP--FRCNQCGK 358
Cdd:COG5048   348 SISPAKEklLNSSSKFspllnnEPPQSLQQYKDLKN-DKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSK 426
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|
gi 1571052945 359 IFSQSNSLQVHKRTHTGEKPYECDRCGKAFPYDSSLRVHK 398
Cdd:COG5048   427 SFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
64-314 4.05e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 4.05e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052945  64 IHTGKKFYECNPCGKAFAYHcHLRIHKRIHTAEKLYKCIQCGKAFSEHNTLQKHKRTHSEEKP------YECNQCGKAFA 137
Cdd:COG5048   193 STSIPSSSENSPLSSSYSIP-SSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSssasesPRSSLPTASSQ 271
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052945 138 HHNILRNHERTHIG-EKPYQCNECDKAFSQHYYLRIHKR--IHTGE--KPYEC--NQCDKAFACLSYLRVHGRTHTGEKP 210
Cdd:COG5048   272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISP 351
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052945 211 YKC--NQCGKVFASHSNLKRHKRTH-----TGEKPYEC--NQCGKAFSDHHTLRIHERAHTGEKP--FECNQCGKTFKLH 279
Cdd:COG5048   352 AKEklLNSSSKFSPLLNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRH 431
                         250       260       270
                  ....*....|....*....|....*....|....*
gi 1571052945 280 SQLRIHKRTHTGEKPHECNQCGKTFACPSSFQKHK 314
Cdd:COG5048   432 YNLIPHKKIHTNHAPLLCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
111-409 4.74e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 4.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052945 111 HNTLQKHKRTHSEE----KPYECNQCGKAFAHHNILRNHERTHIGEKPYQCN--ECDKAFSQHYYLRIHKRIHTGEKPYE 184
Cdd:COG5048    14 SVLSSTPKSTLKSLsnapRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDL 93
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052945 185 CN-QCDKAFACLSYLRVHGRTHTGEKPYKCNQCGKVFASHSNLKRHKRTHTGEKPYECNQCGKAF--------------- 248
Cdd:COG5048    94 NSkSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNNSSSvntpqsnslhpplpa 173
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052945 249 -------SDHHTLRIHERAHTGEKPFECNQCGKTF-KLHSQLRIHKRTH--TGEKPHECNQCG-KTFACPSSFQKHKRIH 317
Cdd:COG5048   174 nslskdpSSNLSLLISSNVSTSIPSSSENSPLSSSySIPSSSSDQNLENssSSLPLTTNSQLSpKSLLSQSPSSLSSSDS 253
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052945 318 TGEKP--YECNQCLKAFAYHSRLRKHERTHTG-EKPFRCNQCGKIFSQSNSLQVHKRT--HTGE--KPYECD--RCGKAF 388
Cdd:COG5048   254 SSSASesPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPysLCGKLF 333
                         330       340
                  ....*....|....*....|.
gi 1571052945 389 PYDSSLRVHKRTHTGVKPYEC 409
Cdd:COG5048   334 SRNDALKRHILLHTSISPAKE 354
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
41-201 2.80e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 2.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052945  41 KPYEEIKYGEAFAHHGSLQIHKR--IHTGKKFYEC----NPCGKAFAYHCHLRIHKRIHTAEKLYKCIQC-------GKA 107
Cdd:COG5048   288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGESLKPFscpySLCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLL 367
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052945 108 FSEHNTLQKHKRTHSEEKPYEC--NQCGKAFAHHNILRNHERTHIGEKPYQCN--ECDKAFSQHYYLRIHKRIHTGEKPY 183
Cdd:COG5048   368 NNEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447
                         170
                  ....*....|....*...
gi 1571052945 184 ECNQCDKAFACLSYLRVH 201
Cdd:COG5048   448 LCSILKSFRRDLDLSNHG 465
zf-H2C2_2 pfam13465
Zinc-finger double domain;
225-249 2.50e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.50e-04
                          10        20
                  ....*....|....*....|....*
gi 1571052945 225 NLKRHKRTHTGEKPYECNQCGKAFS 249
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
169-194 1.52e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 1.52e-03
                          10        20
                  ....*....|....*....|....*.
gi 1571052945 169 YLRIHKRIHTGEKPYECNQCDKAFAC 194
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
142-166 3.37e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.37e-03
                          10        20
                  ....*....|....*....|....*
gi 1571052945 142 LRNHERTHIGEKPYQCNECDKAFSQ 166
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
282-306 3.65e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 3.65e-03
                          10        20
                  ....*....|....*....|....*
gi 1571052945 282 LRIHKRTHTGEKPHECNQCGKTFAC 306
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
150-234 4.49e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 4.49e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1571052945 150 IGEKPYQCN--ECDKAFSQHYYLRIHKRI-HTGEKPYECNQCDKafaclsylrvHGRTHTGEKPYKCNQCGKVFASHSNL 226
Cdd:COG5189   345 KDGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHENPSPEK----------MNIFSAKDKPYRCEVCDKRYKNLNGL 414

                  ....*...
gi 1571052945 227 KRHkRTHT 234
Cdd:COG5189   415 KYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
337-362 4.67e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 4.67e-03
                          10        20
                  ....*....|....*....|....*.
gi 1571052945 337 RLRKHERTHTGEKPFRCNQCGKIFSQ 362
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
114-138 6.14e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.14e-03
                          10        20
                  ....*....|....*....|....*
gi 1571052945 114 LQKHKRTHSEEKPYECNQCGKAFAH 138
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
393-416 6.98e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 6.98e-03
                          10        20
                  ....*....|....*....|....
gi 1571052945 393 SLRVHKRTHTGVKPYECNQCGKAF 416
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
309-334 8.33e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.33e-03
                          10        20
                  ....*....|....*....|....*.
gi 1571052945 309 SFQKHKRIHTGEKPYECNQCLKAFAY 334
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
365-388 8.33e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 8.33e-03
                          10        20
                  ....*....|....*....|....
gi 1571052945 365 SLQVHKRTHTGEKPYECDRCGKAF 388
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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