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Conserved domains on  [gi|1572047481|ref|NP_001355412|]
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Globin domain-containing protein [Caenorhabditis elegans]

Protein Classification

globin( domain architecture ID 10099307)

M-family globin similar to a variety of single-domain globins such as myoglobin and hemoglobin

CATH:  1.10.490.10
Gene Ontology:  GO:0019825|GO:0020037|GO:0005344|GO:0005506|GO:0015671
PubMed:  32863222|16061809|19281958|23209182
SCOP:  4000551

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mb-like cd01040
myoglobin-like; M family globin domain; This family includes chimeric (FHbs/flavohemoglobins) ...
 64-200 4.35e-18

myoglobin-like; M family globin domain; This family includes chimeric (FHbs/flavohemoglobins) and single-domain globins: FHbs, Ngbs/neuroglobins, Cygb/cytoglobins, GbE/avian eye specific globin E, GbX/globin X, amphibian GbY/globin Y, Mb/myoglobin, HbA/hemoglobin-alpha, HbB/hemoglobin-beta, SDgbs/single-domain globins related to FHbs, and Adgb/androglobin. The M family exhibits the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments (named A through H). In Adgbs, the globin domain is split into two: helices C-H are followed by helices A-B and the two parts are separated by the IQ motif. Although rearranged, the globin domain of most Adgbs contains a number of conserved residues which play critical roles in heme-coordination and gas ligand binding. Adgbs have been omitted from this A-H helix cd.


:

Pssm-ID: 381254  Cd Length: 133  Bit Score: 77.88  E-value: 4.35e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1572047481  64 SWRLLKPQASACFRKIFLELEIASPKVKQIFYKAALVDAFNKdddNSATMEVHIKLTTKFFDELLVSLDDETEFVNKIRG 143
Cdd:cd01040     4 SWARVKKDKEEFGVAIFLRLFEANPELKKLFPKFAGVDLDLK---GSPEFKAHAKRVVGALDSLIDNLDDPEALDALLRK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1572047481 144 IGSAHAILakgsNFSSDIWERLGEIAMERVCSHEVVTKTREASRAWRTLIAILIDEL 200
Cdd:cd01040    81 LGKRHKRR----GVTPEHFEVFGEALLETLEEVLGEAFTPEVEAAWRKLLDYIANAI 133
 
Name Accession Description Interval E-value
Mb-like cd01040
myoglobin-like; M family globin domain; This family includes chimeric (FHbs/flavohemoglobins) ...
 64-200 4.35e-18

myoglobin-like; M family globin domain; This family includes chimeric (FHbs/flavohemoglobins) and single-domain globins: FHbs, Ngbs/neuroglobins, Cygb/cytoglobins, GbE/avian eye specific globin E, GbX/globin X, amphibian GbY/globin Y, Mb/myoglobin, HbA/hemoglobin-alpha, HbB/hemoglobin-beta, SDgbs/single-domain globins related to FHbs, and Adgb/androglobin. The M family exhibits the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments (named A through H). In Adgbs, the globin domain is split into two: helices C-H are followed by helices A-B and the two parts are separated by the IQ motif. Although rearranged, the globin domain of most Adgbs contains a number of conserved residues which play critical roles in heme-coordination and gas ligand binding. Adgbs have been omitted from this A-H helix cd.


Pssm-ID: 381254  Cd Length: 133  Bit Score: 77.88  E-value: 4.35e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1572047481  64 SWRLLKPQASACFRKIFLELEIASPKVKQIFYKAALVDAFNKdddNSATMEVHIKLTTKFFDELLVSLDDETEFVNKIRG 143
Cdd:cd01040     4 SWARVKKDKEEFGVAIFLRLFEANPELKKLFPKFAGVDLDLK---GSPEFKAHAKRVVGALDSLIDNLDDPEALDALLRK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1572047481 144 IGSAHAILakgsNFSSDIWERLGEIAMERVCSHEVVTKTREASRAWRTLIAILIDEL 200
Cdd:cd01040    81 LGKRHKRR----GVTPEHFEVFGEALLETLEEVLGEAFTPEVEAAWRKLLDYIANAI 133
Globin pfam00042
Globin;
77-200 7.43e-05

Globin;


Pssm-ID: 459646 [Multi-domain]  Cd Length: 117  Bit Score: 41.12  E-value: 7.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1572047481  77 RKIFLELEIASPKVKQIFYKAALVDAFNKdddNSATMEVHIKLTTKFFDELLVSLDDETEFVNKIRGIGSAHAILAKgsn 156
Cdd:pfam00042   1 AEILARLFTAYPDTKAYFPRFEKSADDLK---GSPKFKAHGKKVLAALGEAVKHLDDLAALNAALKKLGARHKEKRG--- 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1572047481 157 FSSDIWERLGEiAMERVCSHEVVTKTREASRAWRTLIAILIDEL 200
Cdd:pfam00042  75 VDPANFKLFGE-ALLVVLAEHLGEFTPETKAAWDKALDVIAAAL 117
 
Name Accession Description Interval E-value
Mb-like cd01040
myoglobin-like; M family globin domain; This family includes chimeric (FHbs/flavohemoglobins) ...
 64-200 4.35e-18

myoglobin-like; M family globin domain; This family includes chimeric (FHbs/flavohemoglobins) and single-domain globins: FHbs, Ngbs/neuroglobins, Cygb/cytoglobins, GbE/avian eye specific globin E, GbX/globin X, amphibian GbY/globin Y, Mb/myoglobin, HbA/hemoglobin-alpha, HbB/hemoglobin-beta, SDgbs/single-domain globins related to FHbs, and Adgb/androglobin. The M family exhibits the canonical secondary structure of hemoglobins, a 3-over-3 alpha-helical sandwich structure (3/3 Mb-fold), built by eight alpha-helical segments (named A through H). In Adgbs, the globin domain is split into two: helices C-H are followed by helices A-B and the two parts are separated by the IQ motif. Although rearranged, the globin domain of most Adgbs contains a number of conserved residues which play critical roles in heme-coordination and gas ligand binding. Adgbs have been omitted from this A-H helix cd.


Pssm-ID: 381254  Cd Length: 133  Bit Score: 77.88  E-value: 4.35e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1572047481  64 SWRLLKPQASACFRKIFLELEIASPKVKQIFYKAALVDAFNKdddNSATMEVHIKLTTKFFDELLVSLDDETEFVNKIRG 143
Cdd:cd01040     4 SWARVKKDKEEFGVAIFLRLFEANPELKKLFPKFAGVDLDLK---GSPEFKAHAKRVVGALDSLIDNLDDPEALDALLRK 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1572047481 144 IGSAHAILakgsNFSSDIWERLGEIAMERVCSHEVVTKTREASRAWRTLIAILIDEL 200
Cdd:cd01040    81 LGKRHKRR----GVTPEHFEVFGEALLETLEEVLGEAFTPEVEAAWRKLLDYIANAI 133
Globin pfam00042
Globin;
77-200 7.43e-05

Globin;


Pssm-ID: 459646 [Multi-domain]  Cd Length: 117  Bit Score: 41.12  E-value: 7.43e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1572047481  77 RKIFLELEIASPKVKQIFYKAALVDAFNKdddNSATMEVHIKLTTKFFDELLVSLDDETEFVNKIRGIGSAHAILAKgsn 156
Cdd:pfam00042   1 AEILARLFTAYPDTKAYFPRFEKSADDLK---GSPKFKAHGKKVLAALGEAVKHLDDLAALNAALKKLGARHKEKRG--- 74

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....
gi 1572047481 157 FSSDIWERLGEiAMERVCSHEVVTKTREASRAWRTLIAILIDEL 200
Cdd:pfam00042  75 VDPANFKLFGE-ALLVVLAEHLGEFTPETKAAWDKALDVIAAAL 117
CeGLB25-like cd14766
Caenorhabditis elegans globin GLB-25, and related globins; The C. elegans genome contains 33 ...
 64-173 9.32e-03

Caenorhabditis elegans globin GLB-25, and related globins; The C. elegans genome contains 33 genes encoding globins that are all transcribed. These are very diverse in gene and protein structure and are localized in a variety of cells. The C. elegans globin GLB-25 (locus tag T06A1.3), like the majority of them, was expressed in neuronal cells in the head and tail portions of the body and in the nerve cord.


Pssm-ID: 381279  Cd Length: 137  Bit Score: 35.76  E-value: 9.32e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1572047481  64 SWRLLKPQASACFRKIFLELEIASPKVKQIFYKAALVDAFNKDDDNSATMEVHIKLTTKFFDELLVSLDDETEFVNKIRG 143
Cdd:cd14766     4 SWKGIARKIDETGKTMFLRMLTENPELKELFPKLKNLEDEEDELRSSEILENHAARVMDTLDEAISNIENVDYVIDLLHK 83

                          90       100       110
                  ....*....|....*....|....*....|
gi 1572047481 144 IGSAHailAKGSNFSSDIWERLGEIAMERV 173
Cdd:cd14766    84 VGKMH---AKKPGFRPEMFWKIEEPFLEAV 110
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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