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Conserved domains on  [gi|1635381359|ref|NP_001357390|]
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beta-galactosidase-1-like protein 2 isoform b precursor [Homo sapiens]

Protein Classification

glycoside hydrolase family 35 protein( domain architecture ID 10472897)

glycoside hydrolase family 35 protein similar to Xanthomonas phaseoli beta-galactosidase that catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides

CAZY:  GH35
EC:  3.2.1.-
Gene Ontology:  GO:0004565|GO:0005975
SCOP:  4003303

Graphical summary

 Zoom to residue level

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List of domain hits

Name Accession Description Interval E-value
Glyco_hydro_35 pfam01301
Glycosyl hydrolases family 35;
53-363 1.27e-149

Glycosyl hydrolases family 35;


:

Pssm-ID: 396048 [Multi-domain]  Cd Length: 316  Bit Score: 435.15  E-value: 1.27e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359  53 NFMLEDSTFWIFGGSIHYFRVPREYWRDRLLKMKACGLNTLTTYVPWNLHEPERGKFDFSGNLDLEAFVLMAAEIGLWVI 132
Cdd:pfam01301   1 SFLIDGKRFRLISGSIHYFRIPPEMWPDRLQKAKALGLNAIETYVFWNLHEPEPGQYDFSGILDLVKFIKLAQEAGLYVI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359 133 LRPGPYICSEMDLGGLPSWLLQDPGMRLRTTYKGFTEAVDLYFDHLMSRVVPLQYKRGGPIIAVQVENEYGSYNKDPAYM 212
Cdd:pfam01301  81 LRPGPYICAEWDFGGLPAWLLTVPGIRLRTSDPPFLEAVERYLTALLPKMKPLQATNGGPIIMVQVENEYGSYGVDKAYL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359 213 PYVKKALEDRGIVE-LLLTSD--NKDGLSKGIVQG--VLATINLQSTHELQLLTTFLFNVQGTQPKMVMEYWTGWFDSWG 287
Cdd:pfam01301 161 RALRKAYKEWGADMaLLFTTDgpWGMCLQCGDLPGpdIYATNGFGCGANPPSNFKLLRPFSPNKPLMWSEFWTGWFDHWG 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1635381359 288 GPHNILDSSEVLKTVSAIVDAGSSINLYMFHGGTNFGFMNGAMHfhdYKSDVTSYDYDAVLTEAGDYTAKYMKLRD 363
Cdd:pfam01301 241 GPHAIRPAEDIAFEVARFLAKNSSVNLYMFHGGTNFGFTNGANF---YGPQTTSYDYDAPIDEAGDPTPKYGHLKD 313
 
Name Accession Description Interval E-value
Glyco_hydro_35 pfam01301
Glycosyl hydrolases family 35;
53-363 1.27e-149

Glycosyl hydrolases family 35;


Pssm-ID: 396048 [Multi-domain]  Cd Length: 316  Bit Score: 435.15  E-value: 1.27e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359  53 NFMLEDSTFWIFGGSIHYFRVPREYWRDRLLKMKACGLNTLTTYVPWNLHEPERGKFDFSGNLDLEAFVLMAAEIGLWVI 132
Cdd:pfam01301   1 SFLIDGKRFRLISGSIHYFRIPPEMWPDRLQKAKALGLNAIETYVFWNLHEPEPGQYDFSGILDLVKFIKLAQEAGLYVI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359 133 LRPGPYICSEMDLGGLPSWLLQDPGMRLRTTYKGFTEAVDLYFDHLMSRVVPLQYKRGGPIIAVQVENEYGSYNKDPAYM 212
Cdd:pfam01301  81 LRPGPYICAEWDFGGLPAWLLTVPGIRLRTSDPPFLEAVERYLTALLPKMKPLQATNGGPIIMVQVENEYGSYGVDKAYL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359 213 PYVKKALEDRGIVE-LLLTSD--NKDGLSKGIVQG--VLATINLQSTHELQLLTTFLFNVQGTQPKMVMEYWTGWFDSWG 287
Cdd:pfam01301 161 RALRKAYKEWGADMaLLFTTDgpWGMCLQCGDLPGpdIYATNGFGCGANPPSNFKLLRPFSPNKPLMWSEFWTGWFDHWG 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1635381359 288 GPHNILDSSEVLKTVSAIVDAGSSINLYMFHGGTNFGFMNGAMHfhdYKSDVTSYDYDAVLTEAGDYTAKYMKLRD 363
Cdd:pfam01301 241 GPHAIRPAEDIAFEVARFLAKNSSVNLYMFHGGTNFGFTNGANF---YGPQTTSYDYDAPIDEAGDPTPKYGHLKD 313
GanA COG1874
Beta-galactosidase GanA [Carbohydrate transport and metabolism];
55-494 3.24e-50

Beta-galactosidase GanA [Carbohydrate transport and metabolism];


Pssm-ID: 441478 [Multi-domain]  Cd Length: 609  Bit Score: 183.97  E-value: 3.24e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359  55 MLEDSTFWIFGGSIHYFRVPREYWRDRLLKMKACGLNTLTT-YVPWNLHEPERGKFDFSGnldLEAFVLMAAEIGLWVIL 133
Cdd:COG1874     3 FLLDKPFLILGGDYHPERWPPEVWAEDIRLMKAAGLNTVRIgYFAWNLHEPEEGVFDFDW---LDRFIDLLHEAGLKVIL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359 134 RPGPYIcsemdlggLPSWLLQD-PGMrLRTTYKG-----------------FTEAVDLYFDHLMSRvvplqYKRGGPIIA 195
Cdd:COG1874    80 RTPTAA--------PPAWLLKKyPEI-LPVDADGrrrgfgsrrhycpsspvYREAARRIVRALAER-----YGDHPAVIM 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359 196 VQVENEYGSYNKDP------------------------------------------------------------------ 209
Cdd:COG1874   146 WQVDNEYGSYDYCDacaaafrdwlrerygtldalneawgtafwsqrytdwdeiepprltpttanpslrldfrrfssdqvl 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359 210 AYMPYVKKALEDRGIVELLLTSDNkdGLSKGI-------VQGVLATIN-LQSTHELQLLTTFLFN----VQGTQPKMVME 277
Cdd:COG1874   226 EYLRAQRDILREAGPDVPVTTNFM--GPFPGLdywklarDLDVVSWDNyPDGSAADPDEIAFAHDlmrgLKGGGPFMVME 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359 278 YWTGWFdSWgGPHNIL-DSSEVLKTVSAIVDAG-SSINLYMFHggtnfgfmngAMHFhdyksdVTSYDYDAVLTEAGDYT 355
Cdd:COG1874   304 QWPGWV-NW-GPYNPAkRPGQLRLWSLQALAHGaDGVNYFQWR----------PSRG------GTEYDHDAPLDHAGRPT 365
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359 356 AKYMKLRDFFGSisgiplppppdllpkmpYEPLTPVLYLS-------LWDALKYLGEPIKSekpinmenlpvnGGNGQSF 428
Cdd:COG1874   366 RKFREVRELGAE-----------------LARLPEVPGSRvtarvalLFDWESWWALEIQS------------PPLGQDL 416
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1635381359 429 GYI-----LYETsitssgilsghVHDRG-QVFVNTVSIGFLDYKTtkIAVP---LIQGYTVLRIL--VENRGRVNYG 494
Cdd:COG1874   417 GYVdlvraLYRA-----------LRRAGvTVDIVPPFADLSGYKL--LVAPalyLVSDALAERLLayVENGGRVNYG 480
PLN03059 PLN03059
beta-galactosidase; Provisional
63-368 6.96e-46

beta-galactosidase; Provisional


Pssm-ID: 166698 [Multi-domain]  Cd Length: 840  Bit Score: 174.42  E-value: 6.96e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359  63 IFGGSIHYFRVPREYWRDRLLKMKACGLNTLTTYVPWNLHEPERGKFDFSGNLDLEAFVLMAAEIGLWVILRPGPYICSE 142
Cdd:PLN03059   46 LISGSIHYPRSTPEMWPDLIQKAKDGGLDVIQTYVFWNGHEPSPGNYYFEDRYDLVKFIKVVQAAGLYVHLRIGPYICAE 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359 143 MDLGGLPSWLLQDPGMRLRTTYKGFTEAVDLYFDHL--MSRVVPLQYKRGGPIIAVQVENEYG--SYNKDPAYMPYVKKA 218
Cdd:PLN03059  126 WNFGGFPVWLKYVPGIEFRTDNGPFKAAMQKFTEKIvdMMKSEKLFEPQGGPIILSQIENEYGpvEWEIGAPGKAYTKWA 205
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359 219 LE-----DRGIVELLLTSDNKDglskgivQGVLATINlqsthelQLLTTFLFNVQGTQPKMVMEYWTGWFDSWGG--PHN 291
Cdd:PLN03059  206 ADmavklGTGVPWVMCKQEDAP-------DPVIDTCN-------GFYCENFKPNKDYKPKMWTEAWTGWYTEFGGavPNR 271
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1635381359 292 ilDSSEVLKTVSA-IVDAGSSINLYMFHGGTNFGFMNGAMHFhdyksdVTSYDYDAVLTEAG-DYTAKYMKLRDFFGSI 368
Cdd:PLN03059  272 --PAEDLAFSVARfIQNGGSFINYYMYHGGTNFGRTAGGPFI------ATSYDYDAPLDEYGlPREPKWGHLRDLHKAI 342
 
Name Accession Description Interval E-value
Glyco_hydro_35 pfam01301
Glycosyl hydrolases family 35;
53-363 1.27e-149

Glycosyl hydrolases family 35;


Pssm-ID: 396048 [Multi-domain]  Cd Length: 316  Bit Score: 435.15  E-value: 1.27e-149
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359  53 NFMLEDSTFWIFGGSIHYFRVPREYWRDRLLKMKACGLNTLTTYVPWNLHEPERGKFDFSGNLDLEAFVLMAAEIGLWVI 132
Cdd:pfam01301   1 SFLIDGKRFRLISGSIHYFRIPPEMWPDRLQKAKALGLNAIETYVFWNLHEPEPGQYDFSGILDLVKFIKLAQEAGLYVI 80
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359 133 LRPGPYICSEMDLGGLPSWLLQDPGMRLRTTYKGFTEAVDLYFDHLMSRVVPLQYKRGGPIIAVQVENEYGSYNKDPAYM 212
Cdd:pfam01301  81 LRPGPYICAEWDFGGLPAWLLTVPGIRLRTSDPPFLEAVERYLTALLPKMKPLQATNGGPIIMVQVENEYGSYGVDKAYL 160
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359 213 PYVKKALEDRGIVE-LLLTSD--NKDGLSKGIVQG--VLATINLQSTHELQLLTTFLFNVQGTQPKMVMEYWTGWFDSWG 287
Cdd:pfam01301 161 RALRKAYKEWGADMaLLFTTDgpWGMCLQCGDLPGpdIYATNGFGCGANPPSNFKLLRPFSPNKPLMWSEFWTGWFDHWG 240
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1635381359 288 GPHNILDSSEVLKTVSAIVDAGSSINLYMFHGGTNFGFMNGAMHfhdYKSDVTSYDYDAVLTEAGDYTAKYMKLRD 363
Cdd:pfam01301 241 GPHAIRPAEDIAFEVARFLAKNSSVNLYMFHGGTNFGFTNGANF---YGPQTTSYDYDAPIDEAGDPTPKYGHLKD 313
GanA COG1874
Beta-galactosidase GanA [Carbohydrate transport and metabolism];
55-494 3.24e-50

Beta-galactosidase GanA [Carbohydrate transport and metabolism];


Pssm-ID: 441478 [Multi-domain]  Cd Length: 609  Bit Score: 183.97  E-value: 3.24e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359  55 MLEDSTFWIFGGSIHYFRVPREYWRDRLLKMKACGLNTLTT-YVPWNLHEPERGKFDFSGnldLEAFVLMAAEIGLWVIL 133
Cdd:COG1874     3 FLLDKPFLILGGDYHPERWPPEVWAEDIRLMKAAGLNTVRIgYFAWNLHEPEEGVFDFDW---LDRFIDLLHEAGLKVIL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359 134 RPGPYIcsemdlggLPSWLLQD-PGMrLRTTYKG-----------------FTEAVDLYFDHLMSRvvplqYKRGGPIIA 195
Cdd:COG1874    80 RTPTAA--------PPAWLLKKyPEI-LPVDADGrrrgfgsrrhycpsspvYREAARRIVRALAER-----YGDHPAVIM 145
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359 196 VQVENEYGSYNKDP------------------------------------------------------------------ 209
Cdd:COG1874   146 WQVDNEYGSYDYCDacaaafrdwlrerygtldalneawgtafwsqrytdwdeiepprltpttanpslrldfrrfssdqvl 225
                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359 210 AYMPYVKKALEDRGIVELLLTSDNkdGLSKGI-------VQGVLATIN-LQSTHELQLLTTFLFN----VQGTQPKMVME 277
Cdd:COG1874   226 EYLRAQRDILREAGPDVPVTTNFM--GPFPGLdywklarDLDVVSWDNyPDGSAADPDEIAFAHDlmrgLKGGGPFMVME 303
                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359 278 YWTGWFdSWgGPHNIL-DSSEVLKTVSAIVDAG-SSINLYMFHggtnfgfmngAMHFhdyksdVTSYDYDAVLTEAGDYT 355
Cdd:COG1874   304 QWPGWV-NW-GPYNPAkRPGQLRLWSLQALAHGaDGVNYFQWR----------PSRG------GTEYDHDAPLDHAGRPT 365
                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359 356 AKYMKLRDFFGSisgiplppppdllpkmpYEPLTPVLYLS-------LWDALKYLGEPIKSekpinmenlpvnGGNGQSF 428
Cdd:COG1874   366 RKFREVRELGAE-----------------LARLPEVPGSRvtarvalLFDWESWWALEIQS------------PPLGQDL 416
                         490       500       510       520       530       540       550
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1635381359 429 GYI-----LYETsitssgilsghVHDRG-QVFVNTVSIGFLDYKTtkIAVP---LIQGYTVLRIL--VENRGRVNYG 494
Cdd:COG1874   417 GYVdlvraLYRA-----------LRRAGvTVDIVPPFADLSGYKL--LVAPalyLVSDALAERLLayVENGGRVNYG 480
PLN03059 PLN03059
beta-galactosidase; Provisional
63-368 6.96e-46

beta-galactosidase; Provisional


Pssm-ID: 166698 [Multi-domain]  Cd Length: 840  Bit Score: 174.42  E-value: 6.96e-46
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359  63 IFGGSIHYFRVPREYWRDRLLKMKACGLNTLTTYVPWNLHEPERGKFDFSGNLDLEAFVLMAAEIGLWVILRPGPYICSE 142
Cdd:PLN03059   46 LISGSIHYPRSTPEMWPDLIQKAKDGGLDVIQTYVFWNGHEPSPGNYYFEDRYDLVKFIKVVQAAGLYVHLRIGPYICAE 125
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359 143 MDLGGLPSWLLQDPGMRLRTTYKGFTEAVDLYFDHL--MSRVVPLQYKRGGPIIAVQVENEYG--SYNKDPAYMPYVKKA 218
Cdd:PLN03059  126 WNFGGFPVWLKYVPGIEFRTDNGPFKAAMQKFTEKIvdMMKSEKLFEPQGGPIILSQIENEYGpvEWEIGAPGKAYTKWA 205
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359 219 LE-----DRGIVELLLTSDNKDglskgivQGVLATINlqsthelQLLTTFLFNVQGTQPKMVMEYWTGWFDSWGG--PHN 291
Cdd:PLN03059  206 ADmavklGTGVPWVMCKQEDAP-------DPVIDTCN-------GFYCENFKPNKDYKPKMWTEAWTGWYTEFGGavPNR 271
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1635381359 292 ilDSSEVLKTVSA-IVDAGSSINLYMFHGGTNFGFMNGAMHFhdyksdVTSYDYDAVLTEAG-DYTAKYMKLRDFFGSI 368
Cdd:PLN03059  272 --PAEDLAFSVARfIQNGGSFINYYMYHGGTNFGRTAGGPFI------ATSYDYDAPLDEYGlPREPKWGHLRDLHKAI 342
Glyco_hydro_42 pfam02449
Beta-galactosidase; This group of beta-galactosidase enzymes belong to the glycosyl hydrolase ...
71-222 2.52e-12

Beta-galactosidase; This group of beta-galactosidase enzymes belong to the glycosyl hydrolase 42 family. The enzyme catalyzes the hydrolysis of terminal, non-reducing terminal beta-D-galactosidase residues.


Pssm-ID: 396834  Cd Length: 376  Bit Score: 68.84  E-value: 2.52e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359  71 FRVPREYWRDRLLKMKACGLNTLT-TYVPWNLHEPERGKFDFSGnldLEAFVLMAAEIGLWVILRPGPyicsemdlGGLP 149
Cdd:pfam02449   5 EQWPEETWEEDIRLMKEAGVNVVRiGIFAWAKLEPEEGKYDFEW---LDEVIDLLAKAGIKVILATPT--------AAPP 73
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1635381359 150 SWLLQDPGMRLRTTYKG------------FTEAVDLYFDHLMSRVVPLQYKRGGPIIAVQVENEYGSYNkDPAYMPYVKK 217
Cdd:pfam02449  74 AWLVKKHPEILPVDADGrrrgfgsrhhycPSSPVYREYAARIVEALAERYGDHPALIGWHIDNEYGCHV-SECYCETCER 152

                  ....*....
gi 1635381359 218 A----LEDR 222
Cdd:pfam02449 153 AfrkwLKNR 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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