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Conserved domains on  [gi|1666305136|ref|NP_001357665|]
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transmembrane and coiled-coil domain-containing protein 5A isoform 3 [Homo sapiens]

Protein Classification

TMCO5 domain-containing protein( domain architecture ID 12171749)

TMCO5 domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TMCO5 pfam14992
TMCO5 family; The TMCO5 family includes human transmembrane and coiled-coil domain-containing ...
 27-301 5.39e-134

TMCO5 family; The TMCO5 family includes human transmembrane and coiled-coil domain-containing proteins 5A and 5B.


:

Pssm-ID: 464427 [Multi-domain]  Cd Length: 278  Bit Score: 380.99  E-value: 5.39e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136  27 IISLNMDLERDTQRIDEANQKLLLKIQEREDKIQRLESEIIQTRGLVEDEEWEKENRTTMERERALQELEEETARLERKN 106
Cdd:pfam14992   1 LNSLNSDLEKDLQRLDEANQVLLLKIQEKEEEIQSLEREITLTRSLAEDEEREELNFTIMEKEDALQELELETAKLEKKN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136 107 KTLVHSITELQQKLTRKSQKITNCEQSSPDGALEETKVKLQQLEASYACQEKELLKVMKEYAFVTQLCEDQALYIKKYQE 186
Cdd:pfam14992  81 EILVKSVMELQRKLSRKSDKNTGLEQETLKQMLEELKVKLQQSEESCADQEKELAKVESDYQSVHQLCEDQALCIKKYQE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136 187 TLKKIEEELEALFLEREVSKLVSMNPVEK---EHTSQNNEGTPTQKTARLFSKKIFCCLFFITLFFIRLLSYMFFHVRFI 263
Cdd:pfam14992 161 ILRKMEEEKETRLLEKEVSKAQSNSSQRVklvETIQQNMEKTIIKKQKRIFWKRHFRYLFFMVLIFIRLLGYVLFHLQYI 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1666305136 264 NPDLLVNVLPKVLGRSTLWKLRCFFFPSLTLETEDMLP 301
Cdd:pfam14992 241 NPDLLVDTLPKMLSRRTLWRLRCFLFPFLTLEVEDLLP 278
 
Name Accession Description Interval E-value
TMCO5 pfam14992
TMCO5 family; The TMCO5 family includes human transmembrane and coiled-coil domain-containing ...
 27-301 5.39e-134

TMCO5 family; The TMCO5 family includes human transmembrane and coiled-coil domain-containing proteins 5A and 5B.


Pssm-ID: 464427 [Multi-domain]  Cd Length: 278  Bit Score: 380.99  E-value: 5.39e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136  27 IISLNMDLERDTQRIDEANQKLLLKIQEREDKIQRLESEIIQTRGLVEDEEWEKENRTTMERERALQELEEETARLERKN 106
Cdd:pfam14992   1 LNSLNSDLEKDLQRLDEANQVLLLKIQEKEEEIQSLEREITLTRSLAEDEEREELNFTIMEKEDALQELELETAKLEKKN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136 107 KTLVHSITELQQKLTRKSQKITNCEQSSPDGALEETKVKLQQLEASYACQEKELLKVMKEYAFVTQLCEDQALYIKKYQE 186
Cdd:pfam14992  81 EILVKSVMELQRKLSRKSDKNTGLEQETLKQMLEELKVKLQQSEESCADQEKELAKVESDYQSVHQLCEDQALCIKKYQE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136 187 TLKKIEEELEALFLEREVSKLVSMNPVEK---EHTSQNNEGTPTQKTARLFSKKIFCCLFFITLFFIRLLSYMFFHVRFI 263
Cdd:pfam14992 161 ILRKMEEEKETRLLEKEVSKAQSNSSQRVklvETIQQNMEKTIIKKQKRIFWKRHFRYLFFMVLIFIRLLGYVLFHLQYI 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1666305136 264 NPDLLVNVLPKVLGRSTLWKLRCFFFPSLTLETEDMLP 301
Cdd:pfam14992 241 NPDLLVDTLPKMLSRRTLWRLRCFLFPFLTLEVEDLLP 278
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
33-122 8.11e-06

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 47.16  E-value: 8.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136  33 DLERDTQRIDEANQKLLLKIQEREDKIQRLESEIIQTRglvedeeweKENRTTMERERALQELEEETARLERKNKTLVHS 112
Cdd:COG2433   417 RLEEQVERLEAEVEELEAELEEKDERIERLERELSEAR---------SEERREIRKDREISRLDREIERLERELEEERER 487

                          90
                  ....*....|
gi 1666305136 113 ITELQQKLTR 122
Cdd:COG2433   488 IEELKRKLER 497
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 7-172 4.15e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.05  E-value: 4.15e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136    7 IQRPRSEKMEIS-RLAQSKRNIISLNMDLERDTQRIDEANQKLLL---KIQEREDKIQRLESEIIQTRGLVE-------- 74
Cdd:TIGR02168  297 ISRLEQQKQILReRLANLERQLEELEAQLEELESKLDELAEELAEleeKLEELKEELESLEAELEELEAELEelesrlee 376

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136   75 -DEEWEKENRTTMERERALQELEEETARLERKNKTLVHSITELQQKLTRKSQKITNCEQSSPDGALEETKVKLQQLEASY 153
Cdd:TIGR02168  377 lEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEEL 456

                          170
                   ....*....|....*....
gi 1666305136  154 ACQEKELLKVMKEYAFVTQ 172
Cdd:TIGR02168  457 ERLEEALEELREELEEAEQ 475
PRK12704 PRK12704
phosphodiesterase; Provisional
 39-186 9.18e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 37.45  E-value: 9.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136  39 QRIDEANQKLLLKIQEREDKIQRLESEIIQtrglvEDEEWEKENRTTMERERALQELEEETARLERKNKTLVHSITELQQ 118
Cdd:PRK12704   64 EEIHKLRNEFEKELRERRNELQKLEKRLLQ-----KEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIE 138

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1666305136 119 KLTRKSQKITNceqsspdgaleetkvkLQQLEAsyacqEKELLKVMKEyafvtQLCEDQALYIKKYQE 186
Cdd:PRK12704  139 EQLQELERISG----------------LTAEEA-----KEILLEKVEE-----EARHEAAVLIKEIEE 180
 
Name Accession Description Interval E-value
TMCO5 pfam14992
TMCO5 family; The TMCO5 family includes human transmembrane and coiled-coil domain-containing ...
 27-301 5.39e-134

TMCO5 family; The TMCO5 family includes human transmembrane and coiled-coil domain-containing proteins 5A and 5B.


Pssm-ID: 464427 [Multi-domain]  Cd Length: 278  Bit Score: 380.99  E-value: 5.39e-134
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136  27 IISLNMDLERDTQRIDEANQKLLLKIQEREDKIQRLESEIIQTRGLVEDEEWEKENRTTMERERALQELEEETARLERKN 106
Cdd:pfam14992   1 LNSLNSDLEKDLQRLDEANQVLLLKIQEKEEEIQSLEREITLTRSLAEDEEREELNFTIMEKEDALQELELETAKLEKKN 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136 107 KTLVHSITELQQKLTRKSQKITNCEQSSPDGALEETKVKLQQLEASYACQEKELLKVMKEYAFVTQLCEDQALYIKKYQE 186
Cdd:pfam14992  81 EILVKSVMELQRKLSRKSDKNTGLEQETLKQMLEELKVKLQQSEESCADQEKELAKVESDYQSVHQLCEDQALCIKKYQE 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136 187 TLKKIEEELEALFLEREVSKLVSMNPVEK---EHTSQNNEGTPTQKTARLFSKKIFCCLFFITLFFIRLLSYMFFHVRFI 263
Cdd:pfam14992 161 ILRKMEEEKETRLLEKEVSKAQSNSSQRVklvETIQQNMEKTIIKKQKRIFWKRHFRYLFFMVLIFIRLLGYVLFHLQYI 240

                         250       260       270
                  ....*....|....*....|....*....|....*...
gi 1666305136 264 NPDLLVNVLPKVLGRSTLWKLRCFFFPSLTLETEDMLP 301
Cdd:pfam14992 241 NPDLLVDTLPKMLSRRTLWRLRCFLFPFLTLEVEDLLP 278
COG2433 COG2433
Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];
33-122 8.11e-06

Possible nuclease of RNase H fold, RuvC/YqgF family [General function prediction only];


Pssm-ID: 441980 [Multi-domain]  Cd Length: 644  Bit Score: 47.16  E-value: 8.11e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136  33 DLERDTQRIDEANQKLLLKIQEREDKIQRLESEIIQTRglvedeeweKENRTTMERERALQELEEETARLERKNKTLVHS 112
Cdd:COG2433   417 RLEEQVERLEAEVEELEAELEEKDERIERLERELSEAR---------SEERREIRKDREISRLDREIERLERELEEERER 487

                          90
                  ....*....|
gi 1666305136 113 ITELQQKLTR 122
Cdd:COG2433   488 IEELKRKLER 497
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 7-172 4.15e-05

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 45.05  E-value: 4.15e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136    7 IQRPRSEKMEIS-RLAQSKRNIISLNMDLERDTQRIDEANQKLLL---KIQEREDKIQRLESEIIQTRGLVE-------- 74
Cdd:TIGR02168  297 ISRLEQQKQILReRLANLERQLEELEAQLEELESKLDELAEELAEleeKLEELKEELESLEAELEELEAELEelesrlee 376

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136   75 -DEEWEKENRTTMERERALQELEEETARLERKNKTLVHSITELQQKLTRKSQKITNCEQSSPDGALEETKVKLQQLEASY 153
Cdd:TIGR02168  377 lEEQLETLRSKVAQLELQIASLNNEIERLEARLERLEDRRERLQQEIEELLKKLEEAELKELQAELEELEEELEELQEEL 456

                          170
                   ....*....|....*....
gi 1666305136  154 ACQEKELLKVMKEYAFVTQ 172
Cdd:TIGR02168  457 ERLEEALEELREELEEAEQ 475
COG4913 COG4913
Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];
16-130 9.94e-05

Uncharacterized conserved protein, contains a C-terminal ATPase domain [Function unknown];


Pssm-ID: 443941 [Multi-domain]  Cd Length: 1089  Bit Score: 43.75  E-value: 9.94e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136   16 EISRLAQSKRNIISLNMDLERDTQRIDEANQK---LLLKIQEREDKIQRLESEIIQTRGLVEDEEWEKENRTTMERERAL 92
Cdd:COG4913    669 EIAELEAELERLDASSDDLAALEEQLEELEAEleeLEEELDELKGEIGRLEKELEQAEEELDELQDRLEAAEDLARLELR 748

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....
gi 1666305136   93 QELEE------ETARLERKNKTLVHSITELQQKLTRKSQKITNC 130
Cdd:COG4913    749 ALLEErfaaalGDAVERELRENLEERIDALRARLNRAEEELERA 792
YhaN COG4717
Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];
29-149 2.87e-04

Uncharacterized conserved protein YhaN, contains AAA domain [Function unknown];


Pssm-ID: 443752 [Multi-domain]  Cd Length: 641  Bit Score: 42.45  E-value: 2.87e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136  29 SLNMDLERDTQRIDEANQKLLlKIQEREDKIQRLESEIIQTRGLVEdeewEKENRTTMERERALQELEEETARLERKNKT 108
Cdd:COG4717   136 ALEAELAELPERLEELEERLE-ELRELEEELEELEAELAELQEELE----ELLEQLSLATEEELQDLAEELEELQQRLAE 210

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|.
gi 1666305136 109 LVHSITELQQKLTRKSQKITNCEQSSPDGALEETKVKLQQL 149
Cdd:COG4717   211 LEEELEEAQEELEELEEELEQLENELEAAALEERLKEARLL 251
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 12-168 3.92e-04

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 41.85  E-value: 3.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136  12 SEKMEISRLAQSKRNIISLNMDLERDTQRIDEANQKLllkiQEREDKIQRLESEIIQTRGLVEDEEWEKENRTTMERE-- 89
Cdd:COG1196   219 KEELKELEAELLLLKLRELEAELEELEAELEELEAEL----EELEAELAELEAELEELRLELEELELELEEAQAEEYEll 294

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1666305136  90 RALQELEEETARLERKNKTLVHSITELQQKLTRKSQKITNCEQsspdgALEETKVKLQQLEASYACQEKELLKVMKEYA 168
Cdd:COG1196   295 AELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEE-----ELEELEEELEEAEEELEEAEAELAEAEEALL 368
CwlO1 COG3883
Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function ...
 17-186 4.71e-04

Uncharacterized N-terminal coiled-coil domain of peptidoglycan hydrolase CwlO [Function unknown];


Pssm-ID: 443091 [Multi-domain]  Cd Length: 379  Bit Score: 41.35  E-value: 4.71e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136  17 ISRLAQSKRNIISLNMDLERDTQRIDEANQKlllkIQEREDKIQRLESEIIQTRGLVED--EEWEKENRTTMERERALQE 94
Cdd:COG3883    29 QAELEAAQAELDALQAELEELNEEYNELQAE----LEALQAEIDKLQAEIAEAEAEIEErrEELGERARALYRSGGSVSY 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136  95 LE---------------EETARLERKNKTLVHSITELQQKLTRKSQKitnceqsspdgaLEETKVKLQQLEASYACQEKE 159
Cdd:COG3883   105 LDvllgsesfsdfldrlSALSKIADADADLLEELKADKAELEAKKAE------------LEAKLAELEALKAELEAAKAE 172

                         170       180
                  ....*....|....*....|....*...
gi 1666305136 160 LLKVMKEY-AFVTQLCEDQALYIKKYQE 186
Cdd:COG3883   173 LEAQQAEQeALLAQLSAEEAAAEAQLAE 200
GumC COG3206
Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];
22-191 1.34e-03

Exopolysaccharide export protein/domain GumC/Wzc1 [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442439 [Multi-domain]  Cd Length: 687  Bit Score: 40.39  E-value: 1.34e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136  22 QSKRNIISLNMDLERDTQRIDEANQKLL---LKIQEREDKIQRLESEIIQTRGLVEDEEWEKENRTTMERERALQ-ELEE 97
Cdd:COG3206   202 RQKNGLVDLSEEAKLLLQQLSELESQLAearAELAEAEARLAALRAQLGSGPDALPELLQSPVIQQLRAQLAELEaELAE 281

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136  98 ETARLERKN---KTLVHSITELQQKLTRKSQKITNCEQSspdgALEETKVKLQQLEASYACQEKELLKVMKEYAFVTQLC 174
Cdd:COG3206   282 LSARYTPNHpdvIALRAQIAALRAQLQQEAQRILASLEA----ELEALQAREASLQAQLAQLEARLAELPELEAELRRLE 357

                         170
                  ....*....|....*..
gi 1666305136 175 EDQALYIKKYQETLKKI 191
Cdd:COG3206   358 REVEVARELYESLLQRL 374
DUF5401 pfam17380
Family of unknown function (DUF5401); This is a family of unknown function found in ...
 7-151 1.68e-03

Family of unknown function (DUF5401); This is a family of unknown function found in Chromadorea.


Pssm-ID: 375164 [Multi-domain]  Cd Length: 722  Bit Score: 40.11  E-value: 1.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136   7 IQRPRSEK--MEISRLAQSKRniisLNMDLERDTQRID---EANQKLLLKIQEREDKIQRLESEIIQTRGLVEDEEWEKE 81
Cdd:pfam17380 362 LERIRQEEiaMEISRMRELER----LQMERQQKNERVRqelEAARKVKILEEERQRKIQQQKVEMEQIRAEQEEARQREV 437

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1666305136  82 NRTTMERERALQELEEEtaRLERKnktlvHSITELQQKLTRKSQKITNCEQSSPDGALEET---KVKLQQLEA 151
Cdd:pfam17380 438 RRLEEERAREMERVRLE--EQERQ-----QQVERLRQQEEERKRKKLELEKEKRDRKRAEEqrrKILEKELEE 503
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 18-166 2.57e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 38.37  E-value: 2.57e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136  18 SRLAQSKRNIISLNMDLERDTQRIDEANQKLLLKIQERED---KIQRLESEIIQTRGLVEDEEwEKENRTTMEREraLQE 94
Cdd:COG1579    17 SELDRLEHRLKELPAELAELEDELAALEARLEAAKTELEDlekEIKRLELEIEEVEARIKKYE-EQLGNVRNNKE--YEA 93

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1666305136  95 LEEETARLERKNKTLVHSITELQQKLTRKSQKITNCEQsspdgALEETKVKLQQLEASYACQEKELLKVMKE 166
Cdd:COG1579    94 LQKEIESLKRRISDLEDEILELMERIEELEEELAELEA-----ELAELEAELEEKKAELDEELAELEAELEE 160
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 18-168 3.37e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 38.59  E-value: 3.37e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136  18 SRLAQSKRNIISLNMDLERDTQRIDEANQKLLL---KIQEREDKIQRLESEIIQTRG----------------------- 71
Cdd:COG4942    41 KELAALKKEEKALLKQLAALERRIAALARRIRAleqELAALEAELAELEKEIAELRAeleaqkeelaellralyrlgrqp 120

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136  72 ----LVEDEEWEKENRTTM-------ERERALQELEEETARLERKNKTLVHSITELQQKLTRKSQKITNCEQsspdgALE 140
Cdd:COG4942   121 plalLLSPEDFLDAVRRLQylkylapARREQAEELRADLAELAALRAELEAERAELEALLAELEEERAALEA-----LKA 195

                         170       180
                  ....*....|....*....|....*...
gi 1666305136 141 ETKVKLQQLEASYACQEKELLKVMKEYA 168
Cdd:COG4942   196 ERQKLLARLEKELAELAAELAELQQEAE 223
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 19-189 3.57e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 38.90  E-value: 3.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136   19 RLAQSKRNIISLNMDLERDTQRIDEAN---QKLLLKIQEREDKIQRLESEIIQTRGLVEDEEWEKENRTTMERERALQEL 95
Cdd:TIGR02169  738 RLEELEEDLSSLEQEIENVKSELKELEariEELEEDLHKLEEALNDLEARLSHSRIPEIQAELSKLEEEVSRIEARLREI 817

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136   96 EEETARLERKNKTLVHSITELQQKLTR-KSQKITNCEQ--------SSPDGALEETKVKLQQLEASYACQEKELLKVMKE 166
Cdd:TIGR02169  818 EQKLNRLTLEKEYLEKEIQELQEQRIDlKEQIKSIEKEienlngkkEELEEELEELEAALRDLESRLGDLKKERDELEAQ 897

                          170       180
                   ....*....|....*....|...
gi 1666305136  167 YAFVTQLCEDQALYIKKYQETLK 189
Cdd:TIGR02169  898 LRELERKIEELEAQIEKKRKRLS 920
SMC_prok_B TIGR02168
chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of ...
 48-163 3.80e-03

chromosome segregation protein SMC, common bacterial type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. This family represents the SMC protein of most bacteria. The smc gene is often associated with scpB (TIGR00281) and scpA genes, where scp stands for segregation and condensation protein. SMC was shown (in Caulobacter crescentus) to be induced early in S phase but present and bound to DNA throughout the cell cycle. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274008 [Multi-domain]  Cd Length: 1179  Bit Score: 38.88  E-value: 3.80e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136   48 LLLKIQEREDKIQRLESEIIQTRGLVEDEEwekenrttmereRALQELEEETARLERKNKTLVHSITELQQKLTRKSQKI 127
Cdd:TIGR02168  230 LVLRLEELREELEELQEELKEAEEELEELT------------AELQELEEKLEELRLEVSELEEEIEELQKELYALANEI 297

                           90       100       110
                   ....*....|....*....|....*....|....*.
gi 1666305136  128 TNCEQSspdgaLEETKVKLQQLEASYACQEKELLKV 163
Cdd:TIGR02168  298 SRLEQQ-----KQILRERLANLERQLEELEAQLEEL 328
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 16-160 4.39e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 38.76  E-value: 4.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136  16 EISRLAQSKRNIISLNMDLERDTQRIDEANQKLLL---KIQEREDKIQRLESEIIQTRGLVEDEEWEKENRTTM--ERER 90
Cdd:COG1196   258 LEAELAELEAELEELRLELEELELELEEAQAEEYEllaELARLEQDIARLEERRRELEERLEELEEELAELEEEleELEE 337

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136  91 ALQELEEETARLERKNKTLVHSITELQQKLTRKSQKITNCEQSspdgALEETKVKLQQLEASYACQEKEL 160
Cdd:COG1196   338 ELEELEEELEEAEEELEEAEAELAEAEEALLEAEAELAEAEEE----LEELAEELLEALRAAAELAAQLE 403
Smc COG1196
Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning]; ...
 19-166 4.59e-03

Chromosome segregation ATPase Smc [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 440809 [Multi-domain]  Cd Length: 983  Bit Score: 38.76  E-value: 4.59e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136  19 RLAQSKRNIISLNMDLERDTQRIDEANQKLLLKIQEREDKIQRLESEIIQTRGLVEDEEWEKENRTtmERERALQELEEE 98
Cdd:COG1196   289 EEYELLAELARLEQDIARLEERRRELEERLEELEEELAELEEELEELEEELEELEEELEEAEEELE--EAEAELAEAEEA 366

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136  99 TARLERKNKTLVHSITELQQKLTRKSQKITNCEQ--SSPDGALEETKVKLQQLEASYACQEKELLKVMKE 166
Cdd:COG1196   367 LLEAEAELAEAEEELEELAEELLEALRAAAELAAqlEELEEAEEALLERLERLEEELEELEEALAELEEE 436
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 16-160 4.76e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 38.51  E-value: 4.76e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136   16 EISRLAQSKRNIISLNMDLERDTQRIDEANQKLLLKIQ-------EREDKI--QRLESEIIQTRGLVEDEEWEKENRTTM 86
Cdd:TIGR02169  161 EIAGVAEFDRKKEKALEELEEVEENIERLDLIIDEKRQqlerlrrEREKAEryQALLKEKREYEGYELLKEKEALERQKE 240

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1666305136   87 ERERALQELEEE----TARLERKNKTLvHSITELQQKLTRKSQKITNCEQSSPDGALEETKVKLQQLEASYACQEKEL 160
Cdd:TIGR02169  241 AIERQLASLEEEleklTEEISELEKRL-EEIEQLLEELNKKIKDLGEEEQLRVKEKIGELEAEIASLERSIAEKEREL 317
SMC_prok_A TIGR02169
chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of ...
 18-168 7.00e-03

chromosome segregation protein SMC, primarily archaeal type; SMC (structural maintenance of chromosomes) proteins bind DNA and act in organizing and segregating chromosomes for partition. SMC proteins are found in bacteria, archaea, and eukaryotes. It is found in a single copy and is homodimeric in prokaryotes, but six paralogs (excluded from this family) are found in eukarotes, where SMC proteins are heterodimeric. This family represents the SMC protein of archaea and a few bacteria (Aquifex, Synechocystis, etc); the SMC of other bacteria is described by TIGR02168. The N- and C-terminal domains of this protein are well conserved, but the central hinge region is skewed in composition and highly divergent. [Cellular processes, Cell division, DNA metabolism, Chromosome-associated proteins]


Pssm-ID: 274009 [Multi-domain]  Cd Length: 1164  Bit Score: 38.13  E-value: 7.00e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136   18 SRLAQSKRNIISLNMDLERDTQRIDEANQK---LLLKIQEREDKIQRLESEIIQTRGLVED--EEWEKENRTTMERERAL 92
Cdd:TIGR02169  336 AEIEELEREIEEERKRRDKLTEEYAELKEEledLRAELEEVDKEFAETRDELKDYREKLEKlkREINELKRELDRLQEEL 415

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1666305136   93 QELEEETARLERKNKTLVHSITELQQKLTRKSQKITNCEQ--SSPDGALEETKVKLQQLEASYACQEKELLKVMKEYA 168
Cdd:TIGR02169  416 QRLSEELADLNAAIAGIEAKINELEEEKEDKALEIKKQEWklEQLAADLSKYEQELYDLKEEYDRVEKELSKLQRELA 493
EnvC COG4942
Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, ...
 38-127 8.19e-03

Septal ring factor EnvC, activator of murein hydrolases AmiA and AmiB [Cell cycle control, cell division, chromosome partitioning];


Pssm-ID: 443969 [Multi-domain]  Cd Length: 377  Bit Score: 37.44  E-value: 8.19e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136  38 TQRIDEANQKLllkiQEREDKIQRLESEIIQTRGLVED--EEWEKENRTTMERERALQELEEETARLERKNKTLVHSITE 115
Cdd:COG4942    19 ADAAAEAEAEL----EQLQQEIAELEKELAALKKEEKAllKQLAALERRIAALARRIRALEQELAALEAELAELEKEIAE 94

                          90
                  ....*....|..
gi 1666305136 116 LQQKLTRKSQKI 127
Cdd:COG4942    95 LRAELEAQKEEL 106
DR0291 COG1579
Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General ...
 42-120 9.09e-03

Predicted nucleic acid-binding protein DR0291, contains C4-type Zn-ribbon domain [General function prediction only];


Pssm-ID: 441187 [Multi-domain]  Cd Length: 236  Bit Score: 36.83  E-value: 9.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136  42 DEANQKLLLKIQEREDKIQRLESEIIQTRGLVED--EEWEKENRTTMERERALQELEEETARLERKNKTLVHSITELQQK 119
Cdd:COG1579     2 MPEDLRALLDLQELDSELDRLEHRLKELPAELAEleDELAALEARLEAAKTELEDLEKEIKRLELEIEEVEARIKKYEEQ 81


                  .
gi 1666305136 120 L 120
Cdd:COG1579    82 L 82
PRK12704 PRK12704
phosphodiesterase; Provisional
 39-186 9.18e-03

phosphodiesterase; Provisional


Pssm-ID: 237177 [Multi-domain]  Cd Length: 520  Bit Score: 37.45  E-value: 9.18e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1666305136  39 QRIDEANQKLLLKIQEREDKIQRLESEIIQtrglvEDEEWEKENRTTMERERALQELEEETARLERKNKTLVHSITELQQ 118
Cdd:PRK12704   64 EEIHKLRNEFEKELRERRNELQKLEKRLLQ-----KEENLDRKLELLEKREEELEKKEKELEQKQQELEKKEEELEELIE 138

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1666305136 119 KLTRKSQKITNceqsspdgaleetkvkLQQLEAsyacqEKELLKVMKEyafvtQLCEDQALYIKKYQE 186
Cdd:PRK12704  139 EQLQELERISG----------------LTAEEA-----KEILLEKVEE-----EARHEAAVLIKEIEE 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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