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Conserved domains on  [gi|1702159574|ref|NP_001358405|]
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voltage-dependent calcium channel gamma-5 subunit isoform 2 [Homo sapiens]

Protein Classification

PMP-22/EMP/MP20 family protein( domain architecture ID 229584)

PMP-22/EMP/MP20 family tetraspan membrane protein similar to human claudin-9 (hCLDN-9) which is highly expressed in the inner ear, essential for hearing and a high-affinity receptor of CpE

Gene Ontology:  GO:0016020
PubMed:  19706201

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PMP22_Claudin super family cl21598
PMP-22/EMP/MP20/Claudin family;
18-151 3.18e-07

PMP-22/EMP/MP20/Claudin family;


The actual alignment was detected with superfamily member pfam13903:

Pssm-ID: 473919 [Multi-domain]  Cd Length: 191  Bit Score: 47.80  E-value: 3.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702159574  18 VCGLGLLGIAVSTDYWLYLEEGVivpQNQSTEIKMSLHSGLWRVCFLAGEERGRCFTIEYVMPMNTQLTSESTVNVLKMI 97
Cdd:pfam13903   1 ILAFALLLIAFATDYWLVLDVAL---TGINNYTCLFAHLGLWRHCFKSEVDVDSDNQTRFFGCLNQVPNPFPTFEEEIVS 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1702159574  98 RSATPFP----------LVSLFFMFIGFILNNIGHIRPHRTILAFVsGIFFILSGKLwIFLTVV 151
Cdd:pfam13903  78 FSVTSLPgltrfvqafaILSLVLIVCGVVCGLLALPKQSVFLLLAA-GILFLLSGVL-GLLGVI 139
 
Name Accession Description Interval E-value
Claudin_2 pfam13903
PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight ...
 18-151 3.18e-07

PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight junctions between cells.


Pssm-ID: 372799 [Multi-domain]  Cd Length: 191  Bit Score: 47.80  E-value: 3.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702159574  18 VCGLGLLGIAVSTDYWLYLEEGVivpQNQSTEIKMSLHSGLWRVCFLAGEERGRCFTIEYVMPMNTQLTSESTVNVLKMI 97
Cdd:pfam13903   1 ILAFALLLIAFATDYWLVLDVAL---TGINNYTCLFAHLGLWRHCFKSEVDVDSDNQTRFFGCLNQVPNPFPTFEEEIVS 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1702159574  98 RSATPFP----------LVSLFFMFIGFILNNIGHIRPHRTILAFVsGIFFILSGKLwIFLTVV 151
Cdd:pfam13903  78 FSVTSLPgltrfvqafaILSLVLIVCGVVCGLLALPKQSVFLLLAA-GILFLLSGVL-GLLGVI 139
 
Name Accession Description Interval E-value
Claudin_2 pfam13903
PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight ...
 18-151 3.18e-07

PMP-22/EMP/MP20/Claudin tight junction; Members of this family are claudins, that form tight junctions between cells.


Pssm-ID: 372799 [Multi-domain]  Cd Length: 191  Bit Score: 47.80  E-value: 3.18e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1702159574  18 VCGLGLLGIAVSTDYWLYLEEGVivpQNQSTEIKMSLHSGLWRVCFLAGEERGRCFTIEYVMPMNTQLTSESTVNVLKMI 97
Cdd:pfam13903   1 ILAFALLLIAFATDYWLVLDVAL---TGINNYTCLFAHLGLWRHCFKSEVDVDSDNQTRFFGCLNQVPNPFPTFEEEIVS 77

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1702159574  98 RSATPFP----------LVSLFFMFIGFILNNIGHIRPHRTILAFVsGIFFILSGKLwIFLTVV 151
Cdd:pfam13903  78 FSVTSLPgltrfvqafaILSLVLIVCGVVCGLLALPKQSVFLLLAA-GILFLLSGVL-GLLGVI 139
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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