F-box only protein 38 [Rattus norvegicus]
Protein Classification
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| F-box_FBXO38 | cd22107 | F-box domain found in F-box only protein 38 (FBXO38) and similar proteins; FBXO38, also called ... |
30-73 | 2.02e-22 | ||
F-box domain found in F-box only protein 38 (FBXO38) and similar proteins; FBXO38, also called FBX38, or modulator of KLF7 activity (MoKA), is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It may coactivate the transcription factor Kruppel-like factor 7 (KLF7), but does not seem to promote KLF7 ubiquitination. FBXO38 acts as a crucial regulator of programmed cell death protein-1 (PD-1) protein turnover in T cells by mediating PD-1 ubiquitination and regulating anti-tumor immunity of T cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. : Pssm-ID: 438879 Cd Length: 44 Bit Score: 91.17 E-value: 2.02e-22
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| Name | Accession | Description | Interval | E-value | ||
| F-box_FBXO38 | cd22107 | F-box domain found in F-box only protein 38 (FBXO38) and similar proteins; FBXO38, also called ... |
30-73 | 2.02e-22 | ||
F-box domain found in F-box only protein 38 (FBXO38) and similar proteins; FBXO38, also called FBX38, or modulator of KLF7 activity (MoKA), is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It may coactivate the transcription factor Kruppel-like factor 7 (KLF7), but does not seem to promote KLF7 ubiquitination. FBXO38 acts as a crucial regulator of programmed cell death protein-1 (PD-1) protein turnover in T cells by mediating PD-1 ubiquitination and regulating anti-tumor immunity of T cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438879 Cd Length: 44 Bit Score: 91.17 E-value: 2.02e-22
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| F-box | pfam00646 | F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ... |
32-65 | 1.88e-03 | ||
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 425796 Cd Length: 43 Bit Score: 37.13 E-value: 1.88e-03
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| Name | Accession | Description | Interval | E-value | ||
| F-box_FBXO38 | cd22107 | F-box domain found in F-box only protein 38 (FBXO38) and similar proteins; FBXO38, also called ... |
30-73 | 2.02e-22 | ||
F-box domain found in F-box only protein 38 (FBXO38) and similar proteins; FBXO38, also called FBX38, or modulator of KLF7 activity (MoKA), is part of an SCF (SKP1-cullin-F-box) protein ligase complex. It may coactivate the transcription factor Kruppel-like factor 7 (KLF7), but does not seem to promote KLF7 ubiquitination. FBXO38 acts as a crucial regulator of programmed cell death protein-1 (PD-1) protein turnover in T cells by mediating PD-1 ubiquitination and regulating anti-tumor immunity of T cells. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438879 Cd Length: 44 Bit Score: 91.17 E-value: 2.02e-22
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| F-box_SF | cd09917 | F-box domain superfamily; This short domain is commonly found at the N-terminus of various ... |
31-65 | 1.04e-03 | ||
F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures. Pssm-ID: 438852 Cd Length: 35 Bit Score: 37.81 E-value: 1.04e-03
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| F-box | pfam00646 | F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ... |
32-65 | 1.88e-03 | ||
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 425796 Cd Length: 43 Bit Score: 37.13 E-value: 1.88e-03
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| F-box_FBXO1 | cd22082 | F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called ... |
33-64 | 3.23e-03 | ||
F-box domain found in F-box only protein 1 (FBXO1) and similar proteins; FBXO1, also called FBX1, or cyclin-F, is a substrate-recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of CP110 during G2 phase, thereby acting as an inhibitor of centrosome reduplication. It is the largest among all cyclins and oscillates in the cell cycle like other cyclins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. Pssm-ID: 438854 Cd Length: 52 Bit Score: 36.84 E-value: 3.23e-03
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