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Conserved domains on  [gi|1732634018|ref|NP_001359305|]
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WD repeat-containing protein 17 isoform 8 [Mus musculus]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
13-304 1.27e-60

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 212.08  E-value: 1.27e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018  13 GHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSWAP-GDLncIAGATSRNGAFIWDIQKG 91
Cdd:COG2319   118 GHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPdGKL--LASGSDDGTVRLWDLATG 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018  92 KIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCIIRTVD-GKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIR 169
Cdd:COG2319   195 KLLRTLTGH-TGAVRSVAFSP-DGKLLASGSADGTVRLWDLAtGKLLRTLTgHSGSVRSVAFSPDGR-LLASGSADGTVR 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018 170 VFYVATssNQPLKVFSGHTARVFHVKWSPlrEG-ILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNteiPY--L 246
Cdd:COG2319   272 LWDLAT--GELLRTLTGHSGGVNSVAFSP--DGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkT 344

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1732634018 247 LISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWSL 304
Cdd:COG2319   345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVRLWDL 401
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
13-304 1.27e-60

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 212.08  E-value: 1.27e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018  13 GHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSWAP-GDLncIAGATSRNGAFIWDIQKG 91
Cdd:COG2319   118 GHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPdGKL--LASGSDDGTVRLWDLATG 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018  92 KIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCIIRTVD-GKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIR 169
Cdd:COG2319   195 KLLRTLTGH-TGAVRSVAFSP-DGKLLASGSADGTVRLWDLAtGKLLRTLTgHSGSVRSVAFSPDGR-LLASGSADGTVR 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018 170 VFYVATssNQPLKVFSGHTARVFHVKWSPlrEG-ILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNteiPY--L 246
Cdd:COG2319   272 LWDLAT--GELLRTLTGHSGGVNSVAFSP--DGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkT 344

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1732634018 247 LISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWSL 304
Cdd:COG2319   345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-303 1.15e-59

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 205.65  E-value: 1.15e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018  13 GHVETIFDCKFKPDdPNVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGK 92
Cdd:cd00200     7 GHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018  93 IIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCII-RTVDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRV 170
Cdd:cd00200    85 CVRTLTGH-TSYVSSVAFSP-DGRILSSSSRDKTIKVwDVETGKCLTTLRgHTDWVNSVAFSPDGT-FVASSSQDGTIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018 171 FyvATSSNQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISG 250
Cdd:cd00200   162 W--DLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASG 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1732634018 251 SWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWS 303
Cdd:cd00200   238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 177-217 7.09e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.93  E-value: 7.09e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1732634018  177 SNQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWD 217
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 151-304 7.74e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 56.25  E-value: 7.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018 151 WSQNNKDMIATGCEDKNIRVFYVAtsSNQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVSTLNGh 230
Cdd:PLN00181  540 WNSYIKSQVASSNFEGVVQVWDVA--RSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT- 616

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1732634018 231 TAPVRGLMWNTEIPYLLISGSWDYTIKVWDTRG-GVCLDTVYDHGADVYGLTCHPSRpfTMASCSRDSTVRLWSL 304
Cdd:PLN00181  617 KANICCVQFPSESGRSLAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFVDSS--TLVSSSTDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
178-217 2.70e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 2.70e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1732634018 178 NQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWD 217
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
13-304 1.27e-60

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 212.08  E-value: 1.27e-60
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018  13 GHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSWAP-GDLncIAGATSRNGAFIWDIQKG 91
Cdd:COG2319   118 GHTGAVRSVAFSPDG-KTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPdGKL--LASGSDDGTVRLWDLATG 194

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018  92 KIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCIIRTVD-GKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIR 169
Cdd:COG2319   195 KLLRTLTGH-TGAVRSVAFSP-DGKLLASGSADGTVRLWDLAtGKLLRTLTgHSGSVRSVAFSPDGR-LLASGSADGTVR 271

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018 170 VFYVATssNQPLKVFSGHTARVFHVKWSPlrEG-ILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNteiPY--L 246
Cdd:COG2319   272 LWDLAT--GELLRTLTGHSGGVNSVAFSP--DGkLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFS---PDgkT 344

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 1732634018 247 LISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWSL 304
Cdd:COG2319   345 LASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGR-TLASGSADGTVRLWDL 401
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-303 1.15e-59

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 205.65  E-value: 1.15e-59
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018  13 GHVETIFDCKFKPDdPNVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSWAPgDLNCIAGATSRNGAFIWDIQKGK 92
Cdd:cd00200     7 GHTGGVTCVAFSPD-GKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASA-DGTYLASGSSDKTIRLWDLETGE 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018  93 IIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCII-RTVDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRV 170
Cdd:cd00200    85 CVRTLTGH-TSYVSSVAFSP-DGRILSSSSRDKTIKVwDVETGKCLTTLRgHTDWVNSVAFSPDGT-FVASSSQDGTIKL 161

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018 171 FyvATSSNQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISG 250
Cdd:cd00200   162 W--DLRTGKCVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPD-GYLLASG 237

                         250       260       270       280       290
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1732634018 251 SWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWS 303
Cdd:cd00200   238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK-RLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
9-304 8.55e-57

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 201.29  E-value: 8.55e-57
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018   9 LRELGHVETIFDCKFKPDDPnVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSWAPgDLNCIAGATSRNGAFIWDI 88
Cdd:COG2319    72 ATLLGHTAAVLSVAFSPDGR-LLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP-DGKTLASGSADGTVRLWDL 149

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018  89 QKGKIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDG-FCIIRTVDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDK 166
Cdd:COG2319   150 ATGKLLRTLTGH-SGAVTSVAFSP-DGKLLASGSDDGtVRLWDLATGKLLRTLTgHTGAVRSVAFSPDGK-LLASGSADG 226

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018 167 NIRVFYVATssNQPLKVFSGHTARVFHVKWSPlrEG-ILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNteiP- 244
Cdd:COG2319   227 TVRLWDLAT--GKLLRTLTGHSGSVRSVAFSP--DGrLLASGSADGTVRLWDLATGELLRTLTGHSGGVNSVAFS---Pd 299

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1732634018 245 -YLLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPfTMASCSRDSTVRLWSL 304
Cdd:COG2319   300 gKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTVRLWDL 359
WD40 COG2319
WD40 repeat [General function prediction only];
6-263 1.89e-50

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 183.19  E-value: 1.89e-50
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018   6 WD-----FLREL-GHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSWAPgDLNCIAGATS 79
Cdd:COG2319   147 WDlatgkLLRTLtGHSGAVTSVAFSPDG-KLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP-DGKLLASGSA 224

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018  80 RNGAFIWDIQKGKIIQRFNEHGkNGIFYIAWSHkDSKRIATCSGDG-FCIIRTVDGKLLHKYK-HPAAVFGCDWSQNNKd 157
Cdd:COG2319   225 DGTVRLWDLATGKLLRTLTGHS-GSVRSVAFSP-DGRLLASGSADGtVRLWDLATGELLRTLTgHSGGVNSVAFSPDGK- 301

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018 158 MIATGCEDKNIRVFYVATssNQPLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGL 237
Cdd:COG2319   302 LLASGSDDGTVRLWDLAT--GKLLRTLTGHTGAVRSVAFSPDGK-TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV 378

                         250       260
                  ....*....|....*....|....*.
gi 1732634018 238 MWNTEIPYlLISGSWDYTIKVWDTRG 263
Cdd:COG2319   379 AFSPDGRT-LASGSADGTVRLWDLAT 403
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 3-260 2.57e-45

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 164.82  E-value: 2.57e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018   3 AKKWDF-----LREL-GHVETIFDCKFKPDDpNVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSWAPgDLNCIAG 76
Cdd:cd00200    33 IKVWDLetgelLRTLkGHTGPVRDVAASADG-TYLASGSSDKTIRLWDLETGECVRTLTGHTSYVSSVAFSP-DGRILSS 110

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018  77 ATSRNGAFIWDIQKGKIIQRFNEHgKNGIFYIAWSHkDSKRIATCSGDGFCII-RTVDGKLLHKYK-HPAAVFGCDWSQN 154
Cdd:cd00200   111 SSRDKTIKVWDVETGKCLTTLRGH-TDWVNSVAFSP-DGTFVASSSQDGTIKLwDLRTGKCVATLTgHTGEVNSVAFSPD 188

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018 155 NKDMIATGCeDKNIRVFYVATSsnQPLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVRIWDYTQDACVSTLNGHTAPV 234
Cdd:cd00200   189 GEKLLSSSS-DGTIKLWDLSTG--KCLGTLRGHENGVNSVAFSPDGY-LLASGSEDGTIRVWDLRTGECVQTLSGHTNSV 264

                         250       260
                  ....*....|....*....|....*.
gi 1732634018 235 RGLMWNTEIPYlLISGSWDYTIKVWD 260
Cdd:cd00200   265 TSLAWSPDGKR-LASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 94-304 5.76e-40

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 149.41  E-value: 5.76e-40
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018  94 IQRFNEHGKnGIFYIAWsHKDSKRIATCSGDGFCII-RTVDGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVF 171
Cdd:cd00200     2 RRTLKGHTG-GVTCVAF-SPDGKLLATGSGDGTIKVwDLETGELLRTLKgHTGPVRDVAASADGT-YLASGSSDKTIRLW 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018 172 yvATSSNQPLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISGS 251
Cdd:cd00200    79 --DLETGECVRTLTGHTSYVSSVAFSPDGR-ILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPD-GTFVASSS 154

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1732634018 252 WDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRpFTMASCSRDSTVRLWSL 304
Cdd:cd00200   155 QDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDG-EKLLSSSSDGTIKLWDL 206
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 180-305 5.86e-30

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 120.52  E-value: 5.86e-30
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018 180 PLKVFSGHTARVFHVKWSPLREgILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWnteIPY--LLISGSWDYTIK 257
Cdd:cd00200     1 LRRTLKGHTGGVTCVAFSPDGK-LLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAA---SADgtYLASGSSDKTIR 76

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1732634018 258 VWDTRGGVCLDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWSLI 305
Cdd:cd00200    77 LWDLETGECVRTLTGHTSYVSSVAFSPDGRI-LSSSSRDKTIKVWDVE 123
WD40 COG2319
WD40 repeat [General function prediction only];
67-304 2.07e-29

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 121.94  E-value: 2.07e-29
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018  67 APGDLNCIAGATSRNGAFIWDIQKGKIIQRFNEHGkNGIFYIAWSHKDSKRIATCSGDGFCIIRTVDGKLLHKYK-HPAA 145
Cdd:COG2319     2 LSADGAALAAASADLALALLAAALGALLLLLLGLA-AAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLgHTAA 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018 146 VFGCDWSQNNKdMIATGCEDKNIRVFYVATSsnQPLKVFSGHTARVFHVKWSPLREGILcSGSDDGSVRIWDYTQDACVS 225
Cdd:COG2319    81 VLSVAFSPDGR-LLASASADGTVRLWDLATG--LLLRTLTGHTGAVRSVAFSPDGKTLA-SGSADGTVRLWDLATGKLLR 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018 226 TLNGHTAPVRGLMWNteiP--YLLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHP-SRpfTMASCSRDSTVRLW 302
Cdd:COG2319   157 TLTGHSGAVTSVAFS---PdgKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPdGK--LLASGSADGTVRLW 231


                  ..
gi 1732634018 303 SL 304
Cdd:COG2319   232 DL 233
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 177-217 7.09e-09

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 51.93  E-value: 7.09e-09
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|.
gi 1732634018  177 SNQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWD 217
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSP-DGKYLASGSDDGTIKLWD 40
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 151-304 7.74e-08

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 56.25  E-value: 7.74e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018 151 WSQNNKDMIATGCEDKNIRVFYVAtsSNQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVSTLNGh 230
Cdd:PLN00181  540 WNSYIKSQVASSNFEGVVQVWDVA--RSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSINQGVSIGTIKT- 616

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1732634018 231 TAPVRGLMWNTEIPYLLISGSWDYTIKVWDTRG-GVCLDTVYDHGADVYGLTCHPSRpfTMASCSRDSTVRLWSL 304
Cdd:PLN00181  617 KANICCVQFPSESGRSLAFGSADHKVYYYDLRNpKLPLCTMIGHSKTVSYVRFVDSS--TLVSSSTDNTLKLWDL 689
PTZ00420 PTZ00420
coronin; Provisional
 178-260 1.40e-07

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 55.34  E-value: 1.40e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018 178 NQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQD----------ACVstLNGHTAPVRGLMWNTEIPYLL 247
Cdd:PTZ00420   64 KPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPHNdesvkeikdpQCI--LKGHKKKISIIDWNPMNYYIM 141

                          90
                  ....*....|...
gi 1732634018 248 ISGSWDYTIKVWD 260
Cdd:PTZ00420  142 CSSGFDSFVNIWD 154
WD40 pfam00400
WD domain, G-beta repeat;
178-217 2.70e-07

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 47.73  E-value: 2.70e-07
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1732634018 178 NQPLKVFSGHTARVFHVKWSPlREGILCSGSDDGSVRIWD 217
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSP-DGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 223-260 5.33e-07

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 46.92  E-value: 5.33e-07
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 1732634018  223 CVSTLNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWD 260
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPDGKYL-ASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
223-260 3.62e-06

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 44.26  E-value: 3.62e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 1732634018 223 CVSTLNGHTAPVRGLMWNTEIPYLlISGSWDYTIKVWD 260
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLL-ASGSDDGTVKVWD 39
PTZ00421 PTZ00421
coronin; Provisional
 12-100 7.42e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.51  E-value: 7.42e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018  12 LGHVETIFDCKFKPDDPNVLATASFDGTIKVWDINT--LTAVYTSP-----GNEGVIFALSWAPGDLNCIAGATSRNGAF 84
Cdd:PTZ00421   72 LGQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEegLTQNISDPivhlqGHTKKVGIVSFHPSAMNVLASAGADMVVN 151

                          90
                  ....*....|....*.
gi 1732634018  85 IWDIQKGKIIQRFNEH 100
Cdd:PTZ00421  152 VWDVERGKAVEVIKCH 167
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 85-231 2.82e-05

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 48.16  E-value: 2.82e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018  85 IWDIQKGKIIQRFNEHGKNgIFYIAWSHKDSKRIATCSGDGFCIIRTVD-GKLLHKYKHPAAVFGCDWSQNNKDMIATGC 163
Cdd:PLN00181  559 VWDVARSQLVTEMKEHEKR-VWSIDYSSADPTLLASGSDDGSVKLWSINqGVSIGTIKTKANICCVQFPSESGRSLAFGS 637

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1732634018 164 EDKNIrVFYVATSSNQPLKVFSGHTARVFHVKWspLREGILCSGSDDGSVRIWDYTQDAC------VSTLNGHT 231
Cdd:PLN00181  638 ADHKV-YYYDLRNPKLPLCTMIGHSKTVSYVRF--VDSSTLVSSSTDNTLKLWDLSMSISginetpLHSFMGHT 708
PTZ00420 PTZ00420
coronin; Provisional
 157-217 3.84e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 47.25  E-value: 3.84e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1732634018 157 DMIATGCEDKNIRVFYVATSSNQ------PLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWD 217
Cdd:PTZ00420   88 EILASGSEDLTIRVWEIPHNDESvkeikdPQCILKGHKKKISIIDWNPMNYYIMCSSGFDSFVNIWD 154
PTZ00420 PTZ00420
coronin; Provisional
 211-327 4.12e-05

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 47.25  E-value: 4.12e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018 211 GSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEIPYLLISGSWDYTIKVWDTR-GGVCLDTVYD-------HGADVYGLTC 282
Cdd:PTZ00420   54 GAIRLENQMRKPPVIKLKGHTSSILDLQFNPCFSEILASGSEDLTIRVWEIPhNDESVKEIKDpqcilkgHKKKISIIDW 133

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 1732634018 283 HPSRPFTMASCSRDSTVRLWSLIPLITPLQINI---LADRSWDeVIGN 327
Cdd:PTZ00420  134 NPMNYYIMCSSGFDSFVNIWDIENEKRAFQINMpkkLSSLKWN-IKGN 180
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 13-44 4.73e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.14  E-value: 4.73e-05
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1732634018   13 GHVETIFDCKFKPDDpNVLATASFDGTIKVWD 44
Cdd:smart00320  10 GHTGPVTSVAFSPDG-KYLASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 176-273 1.33e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 45.65  E-value: 1.33e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018 176 SSNQPLKVFSGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVSTLNGHTAPVRGLMWNTEiPYLLISGSWDYT 255
Cdd:PTZ00421  113 NISDPIVHLQGHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWNLD-GSLLCTTSKDKK 191

                          90
                  ....*....|....*...
gi 1732634018 256 IKVWDTRGGVCLDTVYDH 273
Cdd:PTZ00421  192 LNIIDPRDGTIVSSVEAH 209
WD40 pfam00400
WD domain, G-beta repeat;
13-44 1.36e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 1.36e-04
                          10        20        30
                  ....*....|....*....|....*....|..
gi 1732634018  13 GHVETIFDCKFKPDDpNVLATASFDGTIKVWD 44
Cdd:pfam00400   9 GHTGSVTSLAFSPDG-KLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
264-303 1.48e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 40.02  E-value: 1.48e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 1732634018 264 GVCLDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWS 303
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKL-LASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 264-303 1.84e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 1.84e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1732634018  264 GVCLDTVYDHGADVYGLTCHPSRPFtMASCSRDSTVRLWS 303
Cdd:smart00320   2 GELLKTLKGHTGPVTSVAFSPDGKY-LASGSDDGTIKLWD 40
PTZ00421 PTZ00421
coronin; Provisional
 176-301 2.88e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.50  E-value: 2.88e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018 176 SSNQPLKVfsGHTARVFHVKWSPLREGILCSGSDDGSVRIWDYTQDACVST-------LNGHTAPVRGLMWNTEIPYLLI 248
Cdd:PTZ00421   65 ASNPPILL--GQEGPIIDVAFNPFDPQKLFTASEDGTIMGWGIPEEGLTQNisdpivhLQGHTKKVGIVSFHPSAMNVLA 142

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|...
gi 1732634018 249 SGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHpSRPFTMASCSRDSTVRL 301
Cdd:PTZ00421  143 SAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWN-LDGSLLCTTSKDKKLNI 194
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 133-171 6.86e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 38.06  E-value: 6.86e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 1732634018  133 DGKLLHKYK-HPAAVFGCDWSQNNKdMIATGCEDKNIRVF 171
Cdd:smart00320   1 SGELLKTLKgHTGPVTSVAFSPDGK-YLASGSDDGTIKLW 39
PTZ00421 PTZ00421
coronin; Provisional
 13-100 9.92e-04

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 42.57  E-value: 9.92e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1732634018  13 GHVETIFDCKFKPDDPNVLATASFDGTIKVWDINTLTAVYTSPGNEGVIFALSW-APGDLNCiagATSRNGAF-IWDIQK 90
Cdd:PTZ00421  123 GHTKKVGIVSFHPSAMNVLASAGADMVVNVWDVERGKAVEVIKCHSDQITSLEWnLDGSLLC---TTSKDKKLnIIDPRD 199

                          90
                  ....*....|
gi 1732634018  91 GKIIQRFNEH 100
Cdd:PTZ00421  200 GTIVSSVEAH 209
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 236-304 1.77e-03

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 42.00  E-value: 1.77e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1732634018 236 GLMWNTEIPYLLISGSWDYTIKVWDTRGGVCLDTVYDHGADVYGLTCHPSRPFTMASCSRDSTVRLWSL 304
Cdd:PLN00181  537 GICWNSYIKSQVASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYSSADPTLLASGSDDGSVKLWSI 605
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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