Tetraspanin family protein [Caenorhabditis elegans]
Protein Classification
tetraspanin family protein( domain architecture ID 548)
tetraspanin family protein is a transmembrane (TM) glycoprotein with four TM segments that facilitates the interaction of membrane and intracellular signaling molecules (such as integrins, pro-growth factors and their receptors, protein kinase-C) in the formation of membrane signaling microdomains (also referred to as the tetraspanin web)
List of domain hits
| Name | Accession | Description | Interval | E-value | ||
| tetraspanin_LEL super family | cl02781 | Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are ... |
115-176 | 4.31e-03 | ||
Tetraspanin, extracellular domain or large extracellular loop (LEL). Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. The tetraspanin family contains CD9, CD63, CD37, CD53, CD82, CD151, and CD81, amongst others. Tetraspanins are involved in diverse processes such as cell activation and proliferation, adhesion and motility, differentiation, cancer, and others. Their various functions may relate to their ability to act as molecular facilitators, grouping specific cell-surface proteins and affecting formation and stability of signaling complexes. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web", which may also include integrins. The actual alignment was detected with superfamily member cd03164: Pssm-ID: 351888 [Multi-domain] Cd Length: 86 Bit Score: 35.92 E-value: 4.31e-03
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| Name | Accession | Description | Interval | E-value | ||
| CD53_like_LEL | cd03164 | Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. ... |
115-176 | 4.31e-03 | ||
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD53 is a tetraspanin of the lymphoid-myeloid lineage and has been implicated in apoptosis protection. It associates with integrin alpha4beta1. Some of the cellular responses modulated by CD53 may be mediated by JNK activation and/or via the AKT pathway. Pssm-ID: 239417 [Multi-domain] Cd Length: 86 Bit Score: 35.92 E-value: 4.31e-03
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| Name | Accession | Description | Interval | E-value | ||
| CD53_like_LEL | cd03164 | Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. ... |
115-176 | 4.31e-03 | ||
Tetraspanin, extracellular domain or large extracellular loop (LEL), CD53_Like family. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment model spans the extracellular domain between the 3rd and 4th trans-membrane segment. Tetraspanins are involved in diverse processes and their various functions may relate to their ability to act as molecular facilitators. Tetraspanins associate laterally with one another and cluster dynamically with numerous parnter domains in membrane microdomains, forming a network of multimolecular complexes, the "tetraspanin web". CD53 is a tetraspanin of the lymphoid-myeloid lineage and has been implicated in apoptosis protection. It associates with integrin alpha4beta1. Some of the cellular responses modulated by CD53 may be mediated by JNK activation and/or via the AKT pathway. Pssm-ID: 239417 [Multi-domain] Cd Length: 86 Bit Score: 35.92 E-value: 4.31e-03
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