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Conserved domains on  [gi|1734316267|ref|NP_001360455|]
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Dimethylglycine dehydrogenase, mitochondrial [Caenorhabditis elegans]

Protein Classification

DadA and GcvT domain-containing protein( domain architecture ID 11429772)

protein containing domains DadA, FAO_M, and GcvT

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
 441-831 4.27e-80

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


:

Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 262.32  E-value: 4.27e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 441 GRPTdRISGVYGRLKKDGASFSFRNGWEVANSFNMGVqneeylptlIREYEMVTNKCGVIDLSWKGKIEVKGNDAEKLMD 520
Cdd:COG0404     1 FRPL-RRTPLHDRHVALGAKFVDFGGWEMPVQYPGGV---------IAEHLAVREAVGLFDVSHMGKIEVTGPDAAAFLD 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 521 YAIASQIPAL--GKISSGLMLTRHGGILGPMMIFHHDRQRsaFILLTEPERESRDLYWLRRAAaEKKFDVQVSIVSEYLA 598
Cdd:COG0404    71 RLVTNDVSKLkpGRARYTLMLNEDGGIIDDLTVYRLGEDR--FLLVVNAANAAKDLAWLEEHL-PPDFDVTITDVTDDWA 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 599 SLALVGPKSREVLSALTKSDVSDEGFPqkSTRMIRLGPVGVVCARSStSTGQLSYELFHNRAETAKLYNAVMSAGREHGI 678
Cdd:COG0404   148 LLAVQGPKAREVLAKLTDADLSALPFM--SFREGTVAGVPVRVSRTG-YTGEDGFEIYVPAEDAEALWDALLEAGEEFGV 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 679 VNFGQAALNMMRLEHGYKIWGKELTLDTNPFECGIGGLVDFEKKEFIGRESALELKKKdfdDSSRRLAlitfdteeGCVL 758
Cdd:COG0404   225 KPCGLGARDTLRLEAGYPLYGHELDETTTPLEAGLGWAVKLDKGDFIGKEALLRQKEE---GPRRKLV--------GLEL 293

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1734316267 759 DDRYVPSGNEVIRIDGKEarVGQITSGAYNVRLQKPIAFAWIDNAVGK-NERLVVDIGDKRLFATSLETPTIPP 831
Cdd:COG0404   294 DGRGVPRAGAPVLADGEV--VGEVTSGTFSPTLGKSIALAYVPAGLARpGTELEVEIRGKRVPAEVVKPPFYDP 365
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
31-409 2.54e-66

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


:

Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 225.17  E-value: 2.54e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267  31 CVLGSGVAGSSVAYHLTKRNiKDVLLLERAsGVASpsGTSFHSPGLVSASHPAH---RYKPILAHSIELYSKLEAETGVN 107
Cdd:COG0665     6 VVIGGGIAGLSTAYHLARRG-LDVTVLERG-RPGS--GASGRNAGQLRPGLAALadrALVRLAREALDLWRELAAELGID 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 108 IDFQPTGTIRLATNETRLAEFRKYVnrDYYKEGDVcKTTLLTPDQVRELAPDVDHSKILGALHTTNDGTISARALTQALV 187
Cdd:COG0665    82 CDFRRTGVLYLARTEAELAALRAEA--EALRALGL-PVELLDAAELREREPGLGSPDYAGGLYDPDDGHVDPAKLVRALA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 188 VGAKNGGAQVIDGAIPKEIKYDKEkGHWIIALEDGTlVTTRNLINAGGIWANDIARLSGHALPVVVVEHQYAVLTPNKTP 267
Cdd:COG0665   159 RAARAAGVRIREGTPVTGLEREGG-RVTGVRTERGT-VRADAVVLAAGAWSARLLPMLGLRLPLRPVRGYVLVTEPLPDL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 268 GPTPAIIDHDstFYVRKSGDD-YLFGGfeSLEKTVIREDwykkgvptegsksiqADFSRLDDAYKRACDLIPGLQGSKVD 346
Cdd:COG0665   237 PLRPVLDDTG--VYLRPTADGrLLVGG--TAEPAGFDRA---------------PTPERLEALLRRLRRLFPALADAEIV 297

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1734316267 347 -ARAAVFSMTPDGYPLVGPYD--KNYWMSTGF-LDGVSSGGGIGKYLADWIVDGEPPAELFDTDASR 409
Cdd:COG0665   298 rAWAGLRPMTPDGLPIIGRLPgaPGLYVATGHgGHGVTLAPAAGRLLADLILGGEPPLDLAPFSPDR 364
FAO_M super family cl24802
FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent ...
 395-446 7.48e-10

FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent oxidoreductases: Sarcosine dehydrogenase, Dimethylglycine dehydrogenase and Dimethylglycine dehydrogenase. It is situated between the DAO domain (pfam01266) and the GCV_T domain (pfam01571).


The actual alignment was detected with superfamily member pfam16350:

Pssm-ID: 465100  Cd Length: 56  Bit Score: 55.15  E-value: 7.48e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1734316267 395 DGEPPAELFDTDASRYER-WGDRKFFTERSRETYSMYYN--WSYTDRSAGRPTDR 446
Cdd:pfam16350   1 DGEPPIDLWECDIRRFGPhQNNREYLRERVAENYGEVYDihHPNEEREAGRPLRT 55
 
Name Accession Description Interval E-value
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
 441-831 4.27e-80

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 262.32  E-value: 4.27e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 441 GRPTdRISGVYGRLKKDGASFSFRNGWEVANSFNMGVqneeylptlIREYEMVTNKCGVIDLSWKGKIEVKGNDAEKLMD 520
Cdd:COG0404     1 FRPL-RRTPLHDRHVALGAKFVDFGGWEMPVQYPGGV---------IAEHLAVREAVGLFDVSHMGKIEVTGPDAAAFLD 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 521 YAIASQIPAL--GKISSGLMLTRHGGILGPMMIFHHDRQRsaFILLTEPERESRDLYWLRRAAaEKKFDVQVSIVSEYLA 598
Cdd:COG0404    71 RLVTNDVSKLkpGRARYTLMLNEDGGIIDDLTVYRLGEDR--FLLVVNAANAAKDLAWLEEHL-PPDFDVTITDVTDDWA 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 599 SLALVGPKSREVLSALTKSDVSDEGFPqkSTRMIRLGPVGVVCARSStSTGQLSYELFHNRAETAKLYNAVMSAGREHGI 678
Cdd:COG0404   148 LLAVQGPKAREVLAKLTDADLSALPFM--SFREGTVAGVPVRVSRTG-YTGEDGFEIYVPAEDAEALWDALLEAGEEFGV 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 679 VNFGQAALNMMRLEHGYKIWGKELTLDTNPFECGIGGLVDFEKKEFIGRESALELKKKdfdDSSRRLAlitfdteeGCVL 758
Cdd:COG0404   225 KPCGLGARDTLRLEAGYPLYGHELDETTTPLEAGLGWAVKLDKGDFIGKEALLRQKEE---GPRRKLV--------GLEL 293

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1734316267 759 DDRYVPSGNEVIRIDGKEarVGQITSGAYNVRLQKPIAFAWIDNAVGK-NERLVVDIGDKRLFATSLETPTIPP 831
Cdd:COG0404   294 DGRGVPRAGAPVLADGEV--VGEVTSGTFSPTLGKSIALAYVPAGLARpGTELEVEIRGKRVPAEVVKPPFYDP 365
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
31-409 2.54e-66

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 225.17  E-value: 2.54e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267  31 CVLGSGVAGSSVAYHLTKRNiKDVLLLERAsGVASpsGTSFHSPGLVSASHPAH---RYKPILAHSIELYSKLEAETGVN 107
Cdd:COG0665     6 VVIGGGIAGLSTAYHLARRG-LDVTVLERG-RPGS--GASGRNAGQLRPGLAALadrALVRLAREALDLWRELAAELGID 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 108 IDFQPTGTIRLATNETRLAEFRKYVnrDYYKEGDVcKTTLLTPDQVRELAPDVDHSKILGALHTTNDGTISARALTQALV 187
Cdd:COG0665    82 CDFRRTGVLYLARTEAELAALRAEA--EALRALGL-PVELLDAAELREREPGLGSPDYAGGLYDPDDGHVDPAKLVRALA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 188 VGAKNGGAQVIDGAIPKEIKYDKEkGHWIIALEDGTlVTTRNLINAGGIWANDIARLSGHALPVVVVEHQYAVLTPNKTP 267
Cdd:COG0665   159 RAARAAGVRIREGTPVTGLEREGG-RVTGVRTERGT-VRADAVVLAAGAWSARLLPMLGLRLPLRPVRGYVLVTEPLPDL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 268 GPTPAIIDHDstFYVRKSGDD-YLFGGfeSLEKTVIREDwykkgvptegsksiqADFSRLDDAYKRACDLIPGLQGSKVD 346
Cdd:COG0665   237 PLRPVLDDTG--VYLRPTADGrLLVGG--TAEPAGFDRA---------------PTPERLEALLRRLRRLFPALADAEIV 297

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1734316267 347 -ARAAVFSMTPDGYPLVGPYD--KNYWMSTGF-LDGVSSGGGIGKYLADWIVDGEPPAELFDTDASR 409
Cdd:COG0665   298 rAWAGLRPMTPDGLPIIGRLPgaPGLYVATGHgGHGVTLAPAAGRLLADLILGGEPPLDLAPFSPDR 364
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 31-392 2.66e-49

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 177.59  E-value: 2.66e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267  31 CVLGSGVAGSSVAYHLTKRNIkDVLLLERASGVASpsGTSFHSPGLVSA---SHPAHRYKPILAHSIELYSKLEAETGVN 107
Cdd:pfam01266   3 VVIGGGIVGLSTAYELARRGL-SVTLLERGDDPGS--GASGRNAGLIHPglrYLEPSELARLALEALDLWEELEEELGID 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 108 IDFQPTGTIRLATNETRlAEFRKYVNRDYYKEGDVcktTLLTPDQVRELAPDVDhsKILGALHTTNDGTISARALTQALV 187
Cdd:pfam01266  80 CGFRRCGVLVLARDEEE-EALEKLLAALRRLGVPA---ELLDAEELRELEPLLP--GLRGGLFYPDGGHVDPARLLRALA 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 188 VGAKNGGAQVIDGAIPKEIKydKEKGHWIIaledGTLVTTRNLINAGGIWAnDIARLSGHALPVVVVEHQYAVLTPNKTP 267
Cdd:pfam01266 154 RAAEALGVRIIEGTEVTGIE--EEGGVWGV----VTTGEADAVVNAAGAWA-DLLALPGLRLPVRPVRGQVLVLEPLPEA 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 268 G---PTPAIIDHDSTFYVRKSGDDYL-FGGFESLektviredwykkgvptEGSKSIQADFSRLDDAYKRACDLIPGLqgS 343
Cdd:pfam01266 227 LlilPVPITVDPGRGVYLRPRADGRLlLGGTDEE----------------DGFDDPTPDPEEIEELLEAARRLFPAL--A 288

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1734316267 344 KVDARAAVFSMTPDGYPLVG-PYDKNYWMSTGF-LDGVSSGGGIGKYLADW 392
Cdd:pfam01266 289 DIERAWAGLRPLPDGLPIIGrPGSPGLYLATGHgGHGLTLAPGIGKLLAEL 339
GCV_T pfam01571
Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, ...
 451-714 3.69e-49

Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 460255  Cd Length: 254  Bit Score: 174.31  E-value: 3.69e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 451 YGRLKKDGASFSFRNGWEVANSFnmGVQNEeylptlIREYEMVTNKCGVIDLSWKGKIEVKGNDAEKLMDYAIASQIPAL 530
Cdd:pfam01571   1 YDRHVALGAKFVEFAGWEMPVQY--GSNGI------LAEHRAVREAAGLFDVSHMGKIEVSGPDAAAFLQRLTTNDVSKL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 531 --GKISSGLMLTRHGGILGPMMIFHHDRQRsaFILLTEPERESRDLYWLRRAAaeKKFDVQVSIVSEYLASLALVGPKSR 608
Cdd:pfam01571  73 kpGRATYTLMLNERGGVIDDLTVYRLGDDH--FLLVVNAANREKDLAWLRKHA--EKLDVVVVDVTDDYALLALQGPKAR 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 609 EVLSALTKSDVSDEgFPQKSTRMIRLGPVGVVCARSSTsTGQLSYELFHNRAETAKLYNAVMSAGREHGIVNFGQAALNM 688
Cdd:pfam01571 149 EVLEKLTDGDLLEA-LPFFSFREIEIGGVPVRVSRTGY-TGEDGFEIYVPAEDAVELWEALLEAGAELGLRPAGLGARDS 226

                         250       260
                  ....*....|....*....|....*.
gi 1734316267 689 MRLEHGYKIWGKELTLDTNPFECGIG 714
Cdd:pfam01571 227 LRLEAGLPLYGHDLDEETTPLEAGLG 252
gcvT PRK00389
glycine cleavage system aminomethyltransferase GcvT;
486-827 8.24e-43

glycine cleavage system aminomethyltransferase GcvT;


Pssm-ID: 234742 [Multi-domain]  Cd Length: 359  Bit Score: 159.51  E-value: 8.24e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 486 LIREYEMVTNKCGVIDLSWKGKIEVKGNDAEKLMDYAIASQIPAL--GKISSGLMLTRHGGILGPMMIFhhdRQRSAFIL 563
Cdd:PRK00389   33 IIEEHHAVRTDAGLFDVSHMGEVDVTGPDALAFLQYLLANDVSKLkpGKAQYTCMLNEDGGVIDDLIVY---KLSEDEYL 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 564 L------TEperesRDLYWLRRAAAekKFDVQVSIVSEYLASLALVGPKSREVLSALTKSDVSDEGfPQKSTRMIRLGPV 637
Cdd:PRK00389  110 LvvnaanRE-----KDLAWIKSHAA--GFGVEVTDRSDDLAMIAVQGPKAREKLQKLTDADLSELK-PFFGAQGAEVGGG 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 638 GVVCARSSTsTGQLSYELFHNRAETAKLYNAVMSAGrehgIVNFGQAALNMMRLEHGYKIWGKELTLDTNPFECGIGGLV 717
Cdd:PRK00389  182 DVLVARTGY-TGEDGFEIYLPAEDAEALWDALLEAG----VKPCGLGARDTLRLEAGMPLYGQDMDETITPLEAGLGWTV 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 718 DFE-KKEFIGREsALELKKKdfDDSSRRLAlitfdteeGCVLDDRYVP-SGNEVIRiDGKEarVGQITSGAYNVRLQKPI 795
Cdd:PRK00389  257 KLEeKRDFIGRE-ALEAQKE--AGVERKLV--------GLELEERGIPrHGYPVLA-DGEE--IGEVTSGTFSPTLGKSI 322

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1734316267 796 AFAWIDNAVGknERLVVDIGDKRLFATSLETP 827
Cdd:PRK00389  323 ALAYVPAGVG--DEVEVEIRGKQVPAKVVKPP 352
mnmC PRK01747
bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent ...
 20-410 1.30e-10

bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC;


Pssm-ID: 234978 [Multi-domain]  Cd Length: 662  Bit Score: 64.87  E-value: 1.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267  20 RNSSSTKHvfACVLGSGVAGSSVAYHLTKRNiKDVLLLERASGVAspSGTS------FHSpgLVSASHPA----HRYKpi 89
Cdd:PRK01747  255 PGSPKARD--AAIIGGGIAGAALALALARRG-WQVTLYEADEAPA--QGASgnrqgaLYP--LLSKDDNAlsrfFRAA-- 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267  90 LAHSIELYSKLEAEtGVNIDFQPTGTIRLATNETRLAEFRKYVNRDYYKEgdvcKTTLLTPDQVRELAP-DVDHskilGA 168
Cdd:PRK01747  326 FLFARRFYDALPAA-GVAFDHDWCGVLQLAWDEKSAEKIAKMLALGLPAE----LARALDAEEAEELAGlPVPC----GG 396

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 169 LHTTNDGTISARALTQALVVGAKNG-----GAQVIDgaipkeikYDKEKGHWIIALEDGTLVTTRNLINAGGiwaNDIAR 243
Cdd:PRK01747  397 IFYPQGGWLCPAELCRALLALAGQQltihfGHEVAR--------LEREDDGWQLDFAGGTLASAPVVVLANG---HDAAR 465

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 244 LSG-HALPVVVVEHQyavLT--PnktpgPTPAiidhdstfyvrksgddylfggfESLEKTVIREDWYKKGVPTEGSKSIQ 320
Cdd:PRK01747  466 FAQtAHLPLYSVRGQ---VShlP-----TTPA----------------------LSALKQVLCYDGYLTPQPANGTHCIG 515

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 321 ADFSRLDD--AYK---------RACDLIPGLQGSK-VD-----ARAAVFSMTPDGYPLVG-------------------- 363
Cdd:PRK01747  516 ASYDRDDTdtAFReadhqenleRLAECLPQALWAKeVDvsalqGRVGFRCASRDRLPMVGnvpdeaatlaeyaalanqqp 595

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1734316267 364 ----PYDKNYWMSTGFLD-GVSSGGGIGKYLADWIvDGEP---PAELFD-TDASRY 410
Cdd:PRK01747  596 ardaPRLPGLYVAGALGSrGLCSAPLGAELLASQI-EGEPlplERDLLAaLHPNRF 650
FAO_M pfam16350
FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent ...
 395-446 7.48e-10

FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent oxidoreductases: Sarcosine dehydrogenase, Dimethylglycine dehydrogenase and Dimethylglycine dehydrogenase. It is situated between the DAO domain (pfam01266) and the GCV_T domain (pfam01571).


Pssm-ID: 465100  Cd Length: 56  Bit Score: 55.15  E-value: 7.48e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1734316267 395 DGEPPAELFDTDASRYER-WGDRKFFTERSRETYSMYYN--WSYTDRSAGRPTDR 446
Cdd:pfam16350   1 DGEPPIDLWECDIRRFGPhQNNREYLRERVAENYGEVYDihHPNEEREAGRPLRT 55
soxA_mon TIGR01377
sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of ...
 30-411 7.85e-10

sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines]


Pssm-ID: 130444 [Multi-domain]  Cd Length: 380  Bit Score: 61.77  E-value: 7.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267  30 ACVLGSGVAGSSVAYHLTKRNIKdVLLLERASGVASpSGTSFHSPGLVSASHPAHRYKPILAHSIELYSKLEAETGVNId 109
Cdd:TIGR01377   3 VIVVGAGIMGCFAAYHLAKHGKK-TLLLEQFDLPHS-RGSSHGQSRIIRKAYPEDFYTPMMLECYQLWAQLEKEAGTKL- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 110 FQPTGTIRLATNETrlaEFRKYVNRDYYKEGdvCKTTLLTPDQVRELAPDVDHSKILGALHTTNDGTISARALTQALVVG 189
Cdd:TIGR01377  80 HRQTGLLLLGPKEN---QFLKTIQATLSRHG--LEHELLSSKQLKQRFPNIRVPRNEVGLLDPNGGVLYAEKALRALQEL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 190 AKNGGAQVIDGAIPKEIKYDkekGHWIIALEDGTLVTTRNLINAGGIWANDIARLSGHALPV-----VVVEHQYAVLTPN 264
Cdd:TIGR01377 155 AEAHGATVRDGTKVVEIEPT---ELLVTVKTTKGSYQANKLVVTAGAWTSKLLSPLGIEIPLqplriNVCYWREKEPGSY 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 265 KTPGPTPAIIDHDSTFYVRksgddylfgGFESLEKTVIREDWYKKGV---PTEGSKSIQADFSRLDDAYKRACDLIPGLQ 341
Cdd:TIGR01377 232 GVSQAFPCFLVLGLNPHIY---------GLPSFEYPGLMKVYYHHGQqidPDERDCPFGADIEDVQILRKFVRDHLPGLN 302

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1734316267 342 GSKVDARAAVFSMTPDGY---PLVGPYDkNYWMSTGFldgvsSGGG------IGKYLADWIVDGEPPAELFDTDASRYE 411
Cdd:TIGR01377 303 GEPKKGEVCMYTNTPDEHfviDLHPKYD-NVVIGAGF-----SGHGfklapvVGKILAELAMKLKPSYDLAIFSLNRFA 375
 
Name Accession Description Interval E-value
GcvT COG0404
Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and ...
 441-831 4.27e-80

Glycine cleavage system protein T (aminomethyltransferase) [Amino acid transport and metabolism]; Glycine cleavage system protein T (aminomethyltransferase) is part of the Pathway/BioSystem: Glycine cleavage


Pssm-ID: 440173 [Multi-domain]  Cd Length: 372  Bit Score: 262.32  E-value: 4.27e-80
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 441 GRPTdRISGVYGRLKKDGASFSFRNGWEVANSFNMGVqneeylptlIREYEMVTNKCGVIDLSWKGKIEVKGNDAEKLMD 520
Cdd:COG0404     1 FRPL-RRTPLHDRHVALGAKFVDFGGWEMPVQYPGGV---------IAEHLAVREAVGLFDVSHMGKIEVTGPDAAAFLD 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 521 YAIASQIPAL--GKISSGLMLTRHGGILGPMMIFHHDRQRsaFILLTEPERESRDLYWLRRAAaEKKFDVQVSIVSEYLA 598
Cdd:COG0404    71 RLVTNDVSKLkpGRARYTLMLNEDGGIIDDLTVYRLGEDR--FLLVVNAANAAKDLAWLEEHL-PPDFDVTITDVTDDWA 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 599 SLALVGPKSREVLSALTKSDVSDEGFPqkSTRMIRLGPVGVVCARSStSTGQLSYELFHNRAETAKLYNAVMSAGREHGI 678
Cdd:COG0404   148 LLAVQGPKAREVLAKLTDADLSALPFM--SFREGTVAGVPVRVSRTG-YTGEDGFEIYVPAEDAEALWDALLEAGEEFGV 224

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 679 VNFGQAALNMMRLEHGYKIWGKELTLDTNPFECGIGGLVDFEKKEFIGRESALELKKKdfdDSSRRLAlitfdteeGCVL 758
Cdd:COG0404   225 KPCGLGARDTLRLEAGYPLYGHELDETTTPLEAGLGWAVKLDKGDFIGKEALLRQKEE---GPRRKLV--------GLEL 293

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1734316267 759 DDRYVPSGNEVIRIDGKEarVGQITSGAYNVRLQKPIAFAWIDNAVGK-NERLVVDIGDKRLFATSLETPTIPP 831
Cdd:COG0404   294 DGRGVPRAGAPVLADGEV--VGEVTSGTFSPTLGKSIALAYVPAGLARpGTELEVEIRGKRVPAEVVKPPFYDP 365
DadA COG0665
Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];
31-409 2.54e-66

Glycine/D-amino acid oxidase (deaminating) [Amino acid transport and metabolism];


Pssm-ID: 440429 [Multi-domain]  Cd Length: 364  Bit Score: 225.17  E-value: 2.54e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267  31 CVLGSGVAGSSVAYHLTKRNiKDVLLLERAsGVASpsGTSFHSPGLVSASHPAH---RYKPILAHSIELYSKLEAETGVN 107
Cdd:COG0665     6 VVIGGGIAGLSTAYHLARRG-LDVTVLERG-RPGS--GASGRNAGQLRPGLAALadrALVRLAREALDLWRELAAELGID 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 108 IDFQPTGTIRLATNETRLAEFRKYVnrDYYKEGDVcKTTLLTPDQVRELAPDVDHSKILGALHTTNDGTISARALTQALV 187
Cdd:COG0665    82 CDFRRTGVLYLARTEAELAALRAEA--EALRALGL-PVELLDAAELREREPGLGSPDYAGGLYDPDDGHVDPAKLVRALA 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 188 VGAKNGGAQVIDGAIPKEIKYDKEkGHWIIALEDGTlVTTRNLINAGGIWANDIARLSGHALPVVVVEHQYAVLTPNKTP 267
Cdd:COG0665   159 RAARAAGVRIREGTPVTGLEREGG-RVTGVRTERGT-VRADAVVLAAGAWSARLLPMLGLRLPLRPVRGYVLVTEPLPDL 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 268 GPTPAIIDHDstFYVRKSGDD-YLFGGfeSLEKTVIREDwykkgvptegsksiqADFSRLDDAYKRACDLIPGLQGSKVD 346
Cdd:COG0665   237 PLRPVLDDTG--VYLRPTADGrLLVGG--TAEPAGFDRA---------------PTPERLEALLRRLRRLFPALADAEIV 297

                         330       340       350       360       370       380
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1734316267 347 -ARAAVFSMTPDGYPLVGPYD--KNYWMSTGF-LDGVSSGGGIGKYLADWIVDGEPPAELFDTDASR 409
Cdd:COG0665   298 rAWAGLRPMTPDGLPIIGRLPgaPGLYVATGHgGHGVTLAPAAGRLLADLILGGEPPLDLAPFSPDR 364
DAO pfam01266
FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: ...
 31-392 2.66e-49

FAD dependent oxidoreductase; This family includes various FAD dependent oxidoreductases: Glycerol-3-phosphate dehydrogenase EC:1.1.99.5, Sarcosine oxidase beta subunit EC:1.5.3.1, D-alanine oxidase EC:1.4.99.1, D-aspartate oxidase EC:1.4.3.1.


Pssm-ID: 426168 [Multi-domain]  Cd Length: 339  Bit Score: 177.59  E-value: 2.66e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267  31 CVLGSGVAGSSVAYHLTKRNIkDVLLLERASGVASpsGTSFHSPGLVSA---SHPAHRYKPILAHSIELYSKLEAETGVN 107
Cdd:pfam01266   3 VVIGGGIVGLSTAYELARRGL-SVTLLERGDDPGS--GASGRNAGLIHPglrYLEPSELARLALEALDLWEELEEELGID 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 108 IDFQPTGTIRLATNETRlAEFRKYVNRDYYKEGDVcktTLLTPDQVRELAPDVDhsKILGALHTTNDGTISARALTQALV 187
Cdd:pfam01266  80 CGFRRCGVLVLARDEEE-EALEKLLAALRRLGVPA---ELLDAEELRELEPLLP--GLRGGLFYPDGGHVDPARLLRALA 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 188 VGAKNGGAQVIDGAIPKEIKydKEKGHWIIaledGTLVTTRNLINAGGIWAnDIARLSGHALPVVVVEHQYAVLTPNKTP 267
Cdd:pfam01266 154 RAAEALGVRIIEGTEVTGIE--EEGGVWGV----VTTGEADAVVNAAGAWA-DLLALPGLRLPVRPVRGQVLVLEPLPEA 226

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 268 G---PTPAIIDHDSTFYVRKSGDDYL-FGGFESLektviredwykkgvptEGSKSIQADFSRLDDAYKRACDLIPGLqgS 343
Cdd:pfam01266 227 LlilPVPITVDPGRGVYLRPRADGRLlLGGTDEE----------------DGFDDPTPDPEEIEELLEAARRLFPAL--A 288

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1734316267 344 KVDARAAVFSMTPDGYPLVG-PYDKNYWMSTGF-LDGVSSGGGIGKYLADW 392
Cdd:pfam01266 289 DIERAWAGLRPLPDGLPIIGrPGSPGLYLATGHgGHGLTLAPGIGKLLAEL 339
GCV_T pfam01571
Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, ...
 451-714 3.69e-49

Aminomethyltransferase folate-binding domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 460255  Cd Length: 254  Bit Score: 174.31  E-value: 3.69e-49
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 451 YGRLKKDGASFSFRNGWEVANSFnmGVQNEeylptlIREYEMVTNKCGVIDLSWKGKIEVKGNDAEKLMDYAIASQIPAL 530
Cdd:pfam01571   1 YDRHVALGAKFVEFAGWEMPVQY--GSNGI------LAEHRAVREAAGLFDVSHMGKIEVSGPDAAAFLQRLTTNDVSKL 72

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 531 --GKISSGLMLTRHGGILGPMMIFHHDRQRsaFILLTEPERESRDLYWLRRAAaeKKFDVQVSIVSEYLASLALVGPKSR 608
Cdd:pfam01571  73 kpGRATYTLMLNERGGVIDDLTVYRLGDDH--FLLVVNAANREKDLAWLRKHA--EKLDVVVVDVTDDYALLALQGPKAR 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 609 EVLSALTKSDVSDEgFPQKSTRMIRLGPVGVVCARSSTsTGQLSYELFHNRAETAKLYNAVMSAGREHGIVNFGQAALNM 688
Cdd:pfam01571 149 EVLEKLTDGDLLEA-LPFFSFREIEIGGVPVRVSRTGY-TGEDGFEIYVPAEDAVELWEALLEAGAELGLRPAGLGARDS 226

                         250       260
                  ....*....|....*....|....*.
gi 1734316267 689 MRLEHGYKIWGKELTLDTNPFECGIG 714
Cdd:pfam01571 227 LRLEAGLPLYGHDLDEETTPLEAGLG 252
gcvT PRK00389
glycine cleavage system aminomethyltransferase GcvT;
486-827 8.24e-43

glycine cleavage system aminomethyltransferase GcvT;


Pssm-ID: 234742 [Multi-domain]  Cd Length: 359  Bit Score: 159.51  E-value: 8.24e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 486 LIREYEMVTNKCGVIDLSWKGKIEVKGNDAEKLMDYAIASQIPAL--GKISSGLMLTRHGGILGPMMIFhhdRQRSAFIL 563
Cdd:PRK00389   33 IIEEHHAVRTDAGLFDVSHMGEVDVTGPDALAFLQYLLANDVSKLkpGKAQYTCMLNEDGGVIDDLIVY---KLSEDEYL 109

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 564 L------TEperesRDLYWLRRAAAekKFDVQVSIVSEYLASLALVGPKSREVLSALTKSDVSDEGfPQKSTRMIRLGPV 637
Cdd:PRK00389  110 LvvnaanRE-----KDLAWIKSHAA--GFGVEVTDRSDDLAMIAVQGPKAREKLQKLTDADLSELK-PFFGAQGAEVGGG 181

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 638 GVVCARSSTsTGQLSYELFHNRAETAKLYNAVMSAGrehgIVNFGQAALNMMRLEHGYKIWGKELTLDTNPFECGIGGLV 717
Cdd:PRK00389  182 DVLVARTGY-TGEDGFEIYLPAEDAEALWDALLEAG----VKPCGLGARDTLRLEAGMPLYGQDMDETITPLEAGLGWTV 256

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 718 DFE-KKEFIGREsALELKKKdfDDSSRRLAlitfdteeGCVLDDRYVP-SGNEVIRiDGKEarVGQITSGAYNVRLQKPI 795
Cdd:PRK00389  257 KLEeKRDFIGRE-ALEAQKE--AGVERKLV--------GLELEERGIPrHGYPVLA-DGEE--IGEVTSGTFSPTLGKSI 322

                         330       340       350
                  ....*....|....*....|....*....|..
gi 1734316267 796 AFAWIDNAVGknERLVVDIGDKRLFATSLETP 827
Cdd:PRK00389  323 ALAYVPAGVG--DEVEVEIRGKQVPAKVVKPP 352
dmdA PRK12486
dimethylsulfoniopropionate demethylase;
463-801 3.45e-17

dimethylsulfoniopropionate demethylase;


Pssm-ID: 237113 [Multi-domain]  Cd Length: 368  Bit Score: 84.03  E-value: 3.45e-17
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 463 FRNGWEVANSFNMGVQNEEYLPTLIR----EYEMVTNKCGVIDLSWKGKIEVKGNDAEKLMDYAIASQIP--ALGKISSG 536
Cdd:PRK12486   16 FSDGVEAAGVKAYTVYNHMLLPTVFEsvedDYAHLKEHVQVWDVAVERQVEIRGPDAARLVQMLTPRDLRgmKPGQCYYV 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 537 LMLTRHGGILGPMMIFHHDRQRsAFILLTEpereSRDLYWLRRAAAEKKFDVQvsIVSEYLASLALVGPKSREVLSALTK 616
Cdd:PRK12486   96 PIVDETGGMLNDPVALKLAEDR-WWISIAD----SDLLLWVKGLANGRKLDVL--VVEPDVSPLAVQGPKADALMARVFG 168

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 617 SDVSDEGFPQ------KSTRMirlgpvgvVCARSSTSTgQLSYELF-HNRAETAKLYNAVMSAGREhgiVNFGQAALNMM 689
Cdd:PRK12486  169 EAIRDLRFFRfgyfdfEGTDL--------VIARSGYSK-QGGFEIYvEGSDLGMPLWDALFEAGKD---LNVRAGCPNLI 236

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 690 -RLEHGYKIWGKELTLDTNPFECGIGGLVDF-EKKEFIGRESALELKKKdfdDSSRRLALITFDTEEgcvlddryVPSGN 767
Cdd:PRK12486  237 eRIEGGLLSYGNDMTRDNTPHECGLGRFCNTqTDIGCIGKDALLRVAKE---GPQKQIRGIKIGGER--------IPPCD 305

                         330       340       350
                  ....*....|....*....|....*....|....
gi 1734316267 768 EVIRIDGKEARVGQITSGAYNVRLQKPIAFAWID 801
Cdd:PRK12486  306 RAWPLLAGDNRVGQVTSAAYSPDFQTNVAIGMVR 339
gcvT PRK13579
glycine cleavage system aminomethyltransferase GcvT;
466-831 7.45e-14

glycine cleavage system aminomethyltransferase GcvT;


Pssm-ID: 237435 [Multi-domain]  Cd Length: 370  Bit Score: 74.21  E-value: 7.45e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 466 GWEVANSFNMGVQnEEYLPTliREyemvtnKCGVIDLSWKGKIEVKGNDAEKLMDYAIASQIPAL--GKISSGLMLTRHG 543
Cdd:PRK13579   30 GYDMPVQYPAGVL-KEHLHT--RA------HAGLFDVSHMGQIEVSGKDAAAALERLVPVDILALkeGRQRYTFFTNEQG 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 544 GILGPMMIFHHDRQrsaFILLTEPERESRDLYWLRRAAAEkkfDVQVSIVSEYlASLALVGPKSREVLSALTkSDVSDEG 623
Cdd:PRK13579  101 GILDDLMVTNLGDH---LFLVVNAACKDADIAHLREHLSD---ECEVNPLDDR-ALLALQGPEAEAVLADLG-PPVAALR 172

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 624 FPQksTRMIRLGPVGVVCARSSTsTGQLSYELFHNRAETAKLYNAVMSAGREHGIvnfGQAALNMMRLEHGYKIWGKELT 703
Cdd:PRK13579  173 FMD--GFEPRLHGVDCFVSRSGY-TGEDGFEISVPADAAEALAEALLADPRVEPI---GLGARDSLRLEAGLCLYGHDID 246

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 704 LDTNPFECGIGGLVDFEKKE---FIGRESALElkkkDFDD--SSRRLALItfdteegcvlddryvPSGNEVIR-----ID 773
Cdd:PRK13579  247 TTTTPVEAALEWAIQKARREaggFPGAKAILA----ALAKgaSRRRVGLK---------------PEGRAPVRegaplFD 307

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 1734316267 774 GKEARVGQITSGAYNVRLQKPIAFAWIDNAVGK-NERLVVDIGDKRLFATSLETPTIPP 831
Cdd:PRK13579  308 DAGTEIGTVTSGGFGPSVGGPVAMGYVPASLAApGTAVFAEVRGKRLPVTVHALPFVPH 366
PLN02319 PLN02319
aminomethyltransferase
 493-830 5.01e-11

aminomethyltransferase


Pssm-ID: 177953 [Multi-domain]  Cd Length: 404  Bit Score: 65.51  E-value: 5.01e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 493 VTNKCGvidLSWKGKievkgnDA----EKLMDYAIASQIPALGKISsgLMLTRHGGILGPMMIFHHDRQRsAFILLTEPE 568
Cdd:PLN02319   80 VSHMCG---LSLKGK------DAipflETLVVADIAGLKDGTGTLS--VFTNEKGGIIDDTVITKVTDDH-IYLVVNAGC 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 569 REsRDLYWLRR--AAAEKKFDVQVSIVSEYLASLALVGPKSREVLSALTKSDVSDEGFpqKSTRMIRLGpvGVVCARSST 646
Cdd:PLN02319  148 RD-KDLAHIEEhmKAFKAKGGDVSWHVHDERSLLALQGPLAAPVLQHLTKEDLSKMYF--GDFRITDIN--GADCFLTRT 222

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 647 S-TGQLSYELFHNRAETAKLYNAVMSagREHGIVNF-GQAALNMMRLEHGYKIWGKELTLDTNPFECGIGGLVDFEKKE- 723
Cdd:PLN02319  223 GyTGEDGFEISVPSEHAVDLAKALLE--KSEGKVRLtGLGARDSLRLEAGLCLYGNDLEEHITPVEAGLAWTIGKRRRAe 300

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 724 --FIGRESAL-ELKKKDfddSSRRLALITfdteEGcvlddryVP--SGNEVIRIDGKEarVGQITSGAYNVRLQKPIAFA 798
Cdd:PLN02319  301 ggFLGADVILkQLKEGV---SRRRVGFIS----SG-------AParSHSEILDESGEK--IGEVTSGGFSPCLKKNIAMG 364

                         330       340       350
                  ....*....|....*....|....*....|...
gi 1734316267 799 WIDNAVGK-NERLVVDIGDKRLFATSLETPTIP 830
Cdd:PLN02319  365 YVKSGFHKaGTEVKVEVRGKMYDAVVTKMPFVP 397
GCV_T_C pfam08669
Glycine cleavage T-protein C-terminal barrel domain; This is a family of glycine cleavage ...
 743-827 1.28e-10

Glycine cleavage T-protein C-terminal barrel domain; This is a family of glycine cleavage T-proteins, part of the glycine cleavage multienzyme complex (GCV) found in bacteria and the mitochondria of eukaryotes. GCV catalyzes the catabolism of glycine in eukaryotes. The T-protein is an aminomethyl transferase.


Pssm-ID: 462554 [Multi-domain]  Cd Length: 80  Bit Score: 58.26  E-value: 1.28e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 743 RRLALITfdteegcVLDDRYVPSGNEVIRIDGKEarVGQITSGAYNVRLQKPIAFAWIDNAVGKN-ERLVVDIGDKRLFA 821
Cdd:pfam08669   1 RRLVGLE-------LDDGDPLLRGGEPVLRDGEV--VGYVTSGAYSPTLGKSIALAYVDAELAKPgTEVEVEIRGKRVPA 71


                  ....*.
gi 1734316267 822 TSLETP 827
Cdd:pfam08669  72 TVVKLP 77
mnmC PRK01747
bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent ...
 20-410 1.30e-10

bifunctional tRNA (5-methylaminomethyl-2-thiouridine)(34)-methyltransferase MnmD/FAD-dependent 5-carboxymethylaminomethyl-2-thiouridine(34) oxidoreductase MnmC;


Pssm-ID: 234978 [Multi-domain]  Cd Length: 662  Bit Score: 64.87  E-value: 1.30e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267  20 RNSSSTKHvfACVLGSGVAGSSVAYHLTKRNiKDVLLLERASGVAspSGTS------FHSpgLVSASHPA----HRYKpi 89
Cdd:PRK01747  255 PGSPKARD--AAIIGGGIAGAALALALARRG-WQVTLYEADEAPA--QGASgnrqgaLYP--LLSKDDNAlsrfFRAA-- 325

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267  90 LAHSIELYSKLEAEtGVNIDFQPTGTIRLATNETRLAEFRKYVNRDYYKEgdvcKTTLLTPDQVRELAP-DVDHskilGA 168
Cdd:PRK01747  326 FLFARRFYDALPAA-GVAFDHDWCGVLQLAWDEKSAEKIAKMLALGLPAE----LARALDAEEAEELAGlPVPC----GG 396

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 169 LHTTNDGTISARALTQALVVGAKNG-----GAQVIDgaipkeikYDKEKGHWIIALEDGTLVTTRNLINAGGiwaNDIAR 243
Cdd:PRK01747  397 IFYPQGGWLCPAELCRALLALAGQQltihfGHEVAR--------LEREDDGWQLDFAGGTLASAPVVVLANG---HDAAR 465

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 244 LSG-HALPVVVVEHQyavLT--PnktpgPTPAiidhdstfyvrksgddylfggfESLEKTVIREDWYKKGVPTEGSKSIQ 320
Cdd:PRK01747  466 FAQtAHLPLYSVRGQ---VShlP-----TTPA----------------------LSALKQVLCYDGYLTPQPANGTHCIG 515

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 321 ADFSRLDD--AYK---------RACDLIPGLQGSK-VD-----ARAAVFSMTPDGYPLVG-------------------- 363
Cdd:PRK01747  516 ASYDRDDTdtAFReadhqenleRLAECLPQALWAKeVDvsalqGRVGFRCASRDRLPMVGnvpdeaatlaeyaalanqqp 595

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1734316267 364 ----PYDKNYWMSTGFLD-GVSSGGGIGKYLADWIvDGEP---PAELFD-TDASRY 410
Cdd:PRK01747  596 ardaPRLPGLYVAGALGSrGLCSAPLGAELLASQI-EGEPlplERDLLAaLHPNRF 650
FAO_M pfam16350
FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent ...
 395-446 7.48e-10

FAD dependent oxidoreductase central domain; This domain occurs in several FAD dependent oxidoreductases: Sarcosine dehydrogenase, Dimethylglycine dehydrogenase and Dimethylglycine dehydrogenase. It is situated between the DAO domain (pfam01266) and the GCV_T domain (pfam01571).


Pssm-ID: 465100  Cd Length: 56  Bit Score: 55.15  E-value: 7.48e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1734316267 395 DGEPPAELFDTDASRYER-WGDRKFFTERSRETYSMYYN--WSYTDRSAGRPTDR 446
Cdd:pfam16350   1 DGEPPIDLWECDIRRFGPhQNNREYLRERVAENYGEVYDihHPNEEREAGRPLRT 55
soxA_mon TIGR01377
sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of ...
 30-411 7.85e-10

sarcosine oxidase, monomeric form; Sarcosine oxidase catalyzes the oxidative demethylation of sarcosine to glycine. The reaction converts tetrahydrofolate to 5,10-methylene-tetrahydrofolate. The enzyme is known in monomeric and heterotetrameric (alpha,beta,gamma,delta) forms [Energy metabolism, Amino acids and amines]


Pssm-ID: 130444 [Multi-domain]  Cd Length: 380  Bit Score: 61.77  E-value: 7.85e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267  30 ACVLGSGVAGSSVAYHLTKRNIKdVLLLERASGVASpSGTSFHSPGLVSASHPAHRYKPILAHSIELYSKLEAETGVNId 109
Cdd:TIGR01377   3 VIVVGAGIMGCFAAYHLAKHGKK-TLLLEQFDLPHS-RGSSHGQSRIIRKAYPEDFYTPMMLECYQLWAQLEKEAGTKL- 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 110 FQPTGTIRLATNETrlaEFRKYVNRDYYKEGdvCKTTLLTPDQVRELAPDVDHSKILGALHTTNDGTISARALTQALVVG 189
Cdd:TIGR01377  80 HRQTGLLLLGPKEN---QFLKTIQATLSRHG--LEHELLSSKQLKQRFPNIRVPRNEVGLLDPNGGVLYAEKALRALQEL 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 190 AKNGGAQVIDGAIPKEIKYDkekGHWIIALEDGTLVTTRNLINAGGIWANDIARLSGHALPV-----VVVEHQYAVLTPN 264
Cdd:TIGR01377 155 AEAHGATVRDGTKVVEIEPT---ELLVTVKTTKGSYQANKLVVTAGAWTSKLLSPLGIEIPLqplriNVCYWREKEPGSY 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 265 KTPGPTPAIIDHDSTFYVRksgddylfgGFESLEKTVIREDWYKKGV---PTEGSKSIQADFSRLDDAYKRACDLIPGLQ 341
Cdd:TIGR01377 232 GVSQAFPCFLVLGLNPHIY---------GLPSFEYPGLMKVYYHHGQqidPDERDCPFGADIEDVQILRKFVRDHLPGLN 302

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1734316267 342 GSKVDARAAVFSMTPDGY---PLVGPYDkNYWMSTGFldgvsSGGG------IGKYLADWIVDGEPPAELFDTDASRYE 411
Cdd:TIGR01377 303 GEPKKGEVCMYTNTPDEHfviDLHPKYD-NVVIGAGF-----SGHGfklapvVGKILAELAMKLKPSYDLAIFSLNRFA 375
PRK11728 PRK11728
L-2-hydroxyglutarate oxidase;
31-265 7.69e-08

L-2-hydroxyglutarate oxidase;


Pssm-ID: 183292 [Multi-domain]  Cd Length: 393  Bit Score: 55.60  E-value: 7.69e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267  31 CVLGSGVAGSSVAYHLTKRNI-KDVLLLERASGVAS-PSGtsfHSPGLVsasHPAHRYKPilahsielySKLEAE---TG 105
Cdd:PRK11728    6 VIIGGGIVGLSTAMQLQERYPgARIAVLEKESGPARhQTG---HNSGVI---HAGVYYTP---------GSLKARfcrRG 70

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 106 V----------NIDFQPTGTIRLATNETRLAEFRKYVNRDyyKEGDVcKTTLLTPDQVRELAPdvdHSKILGALHTTNDG 175
Cdd:PRK11728   71 NeatkafcdqhGIPYEECGKLLVATSELELERMEALYERA--RANGI-EVERLDAEELREREP---NIRGLGAIFVPSTG 144

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 176 TISARALTQALVVGAKNGGAQVIDGAipKEIKYDKEKGHWIIALEDGTlVTTRNLINAGGIWANDIARLSGHALPVVVVE 255
Cdd:PRK11728  145 IVDYRAVAEAMAELIQARGGEIRLGA--EVTALDEHANGVVVRTTQGE-YEARTLINCAGLMSDRLAKMAGLEPDFRIVP 221

                         250
                  ....*....|..
gi 1734316267 256 H--QYAVLTPNK 265
Cdd:PRK11728  222 FrgEYYRLAPEK 233
solA PRK11259
N-methyl-L-tryptophan oxidase;
32-404 2.18e-06

N-methyl-L-tryptophan oxidase;


Pssm-ID: 236887 [Multi-domain]  Cd Length: 376  Bit Score: 50.60  E-value: 2.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267  32 VLGSGVAGSSVAYHLTKRNiKDVLLLERasgvaspsgtsFHSPGLVSASHPAHR-----------YKPILAHSIELYSKL 100
Cdd:PRK11259    8 VIGLGSMGSAAGYYLARRG-LRVLGLDR-----------FMPPHQQGSSHGDTRiirhaygegpaYVPLVLRAQELWREL 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 101 EAETGVNIdFQPTGTIRL--ATNET-----RLAEfrkyvnrdyykEGDVcKTTLLTPDQVRELAPDVDHSKILGALHTTN 173
Cdd:PRK11259   76 ERESGEPL-FVRTGVLNLgpADSDFlansiRSAR-----------QHGL-PHEVLDAAEIRRRFPQFRLPDGYIALFEPD 142

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 174 DGTISARALTQALVVGAKNGGAQVIDGAipKEIKYDKEKGHWIIALEDGTLVTTRNLINAGGiWANDIarLSGHALPVVV 253
Cdd:PRK11259  143 GGFLRPELAIKAHLRLAREAGAELLFNE--PVTAIEADGDGVTVTTADGTYEAKKLVVSAGA-WVKDL--LPPLELPLTP 217

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 254 VEHQYAVLTPNK---TPGPTPAIIDHDStfyvrkSGDDYLfgGFESLEKTVIREDWYKKGVPTEGSKS-IQADFSRLDDA 329
Cdd:PRK11259  218 VRQVLAWFQADGrysEPNRFPAFIWEVP------DGDQYY--GFPAENGPGLKIGKHNGGQEITSPDErDRFVTVAEDGA 289

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 330 YKR--ACDLIPGLqGSKVDARAAVFSMTPDGYPLVG--PYDKNYWMSTGFldgvsSGGG------IGKYLADWIVDGEP- 398
Cdd:PRK11259  290 ELRpfLRNYLPGV-GPCLRGAACTYTNTPDEHFIIDtlPGHPNVLVASGC-----SGHGfkfasvLGEILADLAQDGTSd 363


                  ....*..
gi 1734316267 399 -PAELFD 404
Cdd:PRK11259  364 fDLSPFS 370
CzcO COG2072
Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ...
 22-86 2.25e-04

Predicted flavoprotein CzcO associated with the cation diffusion facilitator CzcD [Inorganic ion transport and metabolism];


Pssm-ID: 441675 [Multi-domain]  Cd Length: 414  Bit Score: 44.47  E-value: 2.25e-04
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1734316267  22 SSSTKHVFACVLGSGVAGSSVAYHLTKRNIkDVLLLERASGVAspsGT--SFHSPGLVSAShPAHRY 86
Cdd:COG2072     1 TAATEHVDVVVIGAGQAGLAAAYHLRRAGI-DFVVLEKADDVG---GTwrDNRYPGLRLDT-PSHLY 62
PRK00711 PRK00711
D-amino acid dehydrogenase;
31-410 2.41e-04

D-amino acid dehydrogenase;


Pssm-ID: 234819 [Multi-domain]  Cd Length: 416  Bit Score: 44.41  E-value: 2.41e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267  31 CVLGSGVAGSSVAYHLTKRNiKDVLLLERASGVASpsGTSFH-----SPGLVS----------------------ASHP- 82
Cdd:PRK00711    4 VVLGSGVIGVTSAWYLAQAG-HEVTVIDRQPGPAL--ETSFAnagqiSPGYAApwaapgvplkaikwlfqrhaplAIRPd 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267  83 -----------------AHRYK-------PILAHSIELYSKLEAETGVNIDFQPTGTIRLATNETRLAEFRKYVNrdyYK 138
Cdd:PRK00711   81 gdpfqlrwmwqmlrnctASRYAvnksrmvRLAEYSRDCLKALRAETGIQYEGRQGGTLQLFRTQQQLDAAAKDIA---VL 157

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 139 EGDVCKTTLLTPDQVRELAPDVDH--SKILGALHTTNDGTISARALTQALVVGAKNGGA-----QVIDGaipkeikYDKE 211
Cdd:PRK00711  158 EEAGVPYELLDRDELAAVEPALAGvrHKLVGGLRLPNDETGDCQLFTQRLAAMAEQLGVkfrfnTPVDG-------LLVE 230

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 212 KGHwIIALE-DGTLVTTRNLINAGGIWANDIARLSGHALPVvvvehqYAV----LT-PNKTPGPTPAIIDHDSTF---YV 282
Cdd:PRK00711  231 GGR-ITGVQtGGGVITADAYVVALGSYSTALLKPLGVDIPV------YPLkgysLTvPITDEDRAPVSTVLDETYkiaIT 303

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 283 RksgddylFGgfeslekTVIRedwykkgvpTEGSKSIqADFS-RLDDAyKRAC------DLIPGlqgsKVDARAAVF--- 352
Cdd:PRK00711  304 R-------FD-------DRIR---------VGGMAEI-VGFDlRLDPA-RRETlemvvrDLFPG----GGDLSQATFwtg 354

                         410       420       430       440       450       460
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1734316267 353 --SMTPDGYPLVG--PYDkNYWMSTGF--LdGVSSGGGIGKYLADWIVDGEPPAELFDTDASRY 410
Cdd:PRK00711  355 lrPMTPDGTPIVGatRYK-NLWLNTGHgtL-GWTMACGSGQLLADLISGRKPAIDADDLSVARY 416
GlpA COG0578
Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate ...
 144-246 2.68e-03

Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Glycerol-3-phosphate dehydrogenase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 440343 [Multi-domain]  Cd Length: 501  Bit Score: 41.27  E-value: 2.68e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1734316267 144 KTTLLTPDQVRELAPDVDHSKILGALH----TTNDgtisARaLTQALVVGAKNGGAQVIDGAIPKEIKYDKEKgHWIIAL 219
Cdd:COG0578   101 RHRRLSRAEALALAPLLRPDGLRGGFEyydaQVDD----AR-LVLELARTAAERGAVVLNYTRVTGLLRDGGR-VWGVTV 174

                          90       100       110
                  ....*....|....*....|....*....|..
gi 1734316267 220 ED---GTL--VTTRNLINAGGIWANDIARLSG 246
Cdd:COG0578   175 RDrltGEEftVRARVVVNATGPWVDELRALDG 206
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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