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Conserved domains on  [gi|1734341502|ref|NP_001360587|]
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C2H2-type domain-containing protein [Caenorhabditis elegans]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 10603440)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940|30718982
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
257-284 3.07e-06

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 3.07e-06
                          10        20
                  ....*....|....*....|....*...
gi 1734341502 257 NLKTHRRTHTGEKPYHCnvPNCNKSFTN 284
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECGKSFKS 26
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 267-327 9.80e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 9.80e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1734341502 267 GEKPYHCNVPNCNKSFTNASDRSKHSKRTHSN------------------EKPYCCDFgsCACAYTDPSSLRKHVKSKH 327
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGLKYHMLHGHQNqklhenpspekmnifsakDKPYRCEV--CDKRYKNLNGLKYHRKHSH 422
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
257-284 3.07e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 3.07e-06
                          10        20
                  ....*....|....*....|....*...
gi 1734341502 257 NLKTHRRTHTGEKPYHCnvPNCNKSFTN 284
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 267-327 9.80e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 9.80e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1734341502 267 GEKPYHCNVPNCNKSFTNASDRSKHSKRTHSN------------------EKPYCCDFgsCACAYTDPSSLRKHVKSKH 327
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGLKYHMLHGHQNqklhenpspekmnifsakDKPYRCEV--CDKRYKNLNGLKYHRKHSH 422
DUF1644 pfam07800
Protein of unknown function (DUF1644); This family consists of sequences found in a number of ...
 294-328 5.78e-03

Protein of unknown function (DUF1644); This family consists of sequences found in a number of hypothetical plant proteins of unknown function. The region of interest contains nine highly conserved cysteine residues and is approximately 160 amino acids in length, and is probably a zinc-binding domain.


Pssm-ID: 462269  Cd Length: 164  Bit Score: 37.56  E-value: 5.78e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1734341502 294 RTHSNEKPYCCDFGSCACA--YTDpssLRKHVKSKHP 328
Cdd:pfam07800 102 RKYLNAKKRSCSEESCSFSgnYKE---LRKHARLEHP 135
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
257-284 3.07e-06

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 43.51  E-value: 3.07e-06
                          10        20
                  ....*....|....*....|....*...
gi 1734341502 257 NLKTHRRTHTGEKPYHCnvPNCNKSFTN 284
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKC--PECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 267-327 9.80e-05

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 9.80e-05
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1734341502 267 GEKPYHCNVPNCNKSFTNASDRSKHSKRTHSN------------------EKPYCCDFgsCACAYTDPSSLRKHVKSKH 327
Cdd:COG5189   346 DGKPYKCPVEGCNKKYKNQNGLKYHMLHGHQNqklhenpspekmnifsakDKPYRCEV--CDKRYKNLNGLKYHRKHSH 422
DUF1644 pfam07800
Protein of unknown function (DUF1644); This family consists of sequences found in a number of ...
 294-328 5.78e-03

Protein of unknown function (DUF1644); This family consists of sequences found in a number of hypothetical plant proteins of unknown function. The region of interest contains nine highly conserved cysteine residues and is approximately 160 amino acids in length, and is probably a zinc-binding domain.


Pssm-ID: 462269  Cd Length: 164  Bit Score: 37.56  E-value: 5.78e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1734341502 294 RTHSNEKPYCCDFGSCACA--YTDpssLRKHVKSKHP 328
Cdd:pfam07800 102 RKYLNAKKRSCSEESCSFSgnYKE---LRKHARLEHP 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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