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Conserved domains on  [gi|1767231820|ref|NP_001361867|]
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Leucine Rich repeat-containing domain protein [Caenorhabditis elegans]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1001123)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions; similar to Oryctolagus cuniculus monocyte differentiation antigen CD14, a coreceptor for bacterial lipopolysaccharide

Gene Ontology:  GO:0005515
PubMed:  11751054

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR super family cl34836
Leucine-rich repeat (LRR) protein [Transcription];
222-407 4.07e-04

Leucine-rich repeat (LRR) protein [Transcription];


The actual alignment was detected with superfamily member COG4886:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 4.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231820 222 TYSKTDEVLRAQLFTSHNFSEKNLAETILKLGFKTITESVIVDKNELKFETLASEIAEVGQYVSTVQDMSVLDVITVNRL 301
Cdd:COG4886    16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231820 302 LEVRpdTLDVSGfcfNLEIFrsiNLEGIKKFTARDHCLNSL-RNFPYLPNCTVLGLSNNNIKECTRILvKQVVNVEHLDL 380
Cdd:COG4886    96 TNLT--ELDLSG---NEELS---NLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPL-GNLTNLKSLDL 166

                         170       180
                  ....*....|....*....|....*..
gi 1767231820 381 RNNFLTmNCTFPLLSLKSLTHLKLSDN 407
Cdd:COG4886   167 SNNQLT-DLPEELGNLTNLKELDLSNN 192
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
222-407 4.07e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 4.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231820 222 TYSKTDEVLRAQLFTSHNFSEKNLAETILKLGFKTITESVIVDKNELKFETLASEIAEVGQYVSTVQDMSVLDVITVNRL 301
Cdd:COG4886    16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231820 302 LEVRpdTLDVSGfcfNLEIFrsiNLEGIKKFTARDHCLNSL-RNFPYLPNCTVLGLSNNNIKECTRILvKQVVNVEHLDL 380
Cdd:COG4886    96 TNLT--ELDLSG---NEELS---NLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPL-GNLTNLKSLDL 166

                         170       180
                  ....*....|....*....|....*..
gi 1767231820 381 RNNFLTmNCTFPLLSLKSLTHLKLSDN 407
Cdd:COG4886   167 SNNQLT-DLPEELGNLTNLKELDLSNN 192
LRR_9 pfam14580
Leucine-rich repeat;
336-407 8.18e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 40.13  E-value: 8.18e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1767231820 336 DHCLNSLRNFPYLPNCTVLGLSNNNIKECTRILVKQVVNVEHLDLRNNFLTMNCTF-PLLSLKSLTHLKLSDN 407
Cdd:pfam14580  51 DNEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDLdPLASLKKLTFLSLLRN 123
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
222-407 4.07e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.61  E-value: 4.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231820 222 TYSKTDEVLRAQLFTSHNFSEKNLAETILKLGFKTITESVIVDKNELKFETLASEIAEVGQYVSTVQDMSVLDVITVNRL 301
Cdd:COG4886    16 LLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDL 95

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231820 302 LEVRpdTLDVSGfcfNLEIFrsiNLEGIKKFTARDHCLNSL-RNFPYLPNCTVLGLSNNNIKECTRILvKQVVNVEHLDL 380
Cdd:COG4886    96 TNLT--ELDLSG---NEELS---NLTNLESLDLSGNQLTDLpEELANLTNLKELDLSNNQLTDLPEPL-GNLTNLKSLDL 166

                         170       180
                  ....*....|....*....|....*..
gi 1767231820 381 RNNFLTmNCTFPLLSLKSLTHLKLSDN 407
Cdd:COG4886   167 SNNQLT-DLPEELGNLTNLKELDLSNN 192
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
232-407 4.97e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.23  E-value: 4.97e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231820 232 AQLFTSHNFSEKNLAETILKLGFKTITESVIVDKNELKFETLASEIAEVGQYVSTVQDMSVLDVITVNRLLEVRPDTLDV 311
Cdd:COG4886     1 LLLLLLSLTLKLLLLLLLELLTTLILLLLLLLLLLALLLLSLLSLLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231820 312 SGFCFNLEIFRSINLEGIKKFTardhcLNSLRNFPYLPNCTVLGLSNNNIKECTRILvKQVVNVEHLDLRNNFLTmncTF 391
Cdd:COG4886    81 LLSLLLLGLTDLGDLTNLTELD-----LSGNEELSNLTNLESLDLSGNQLTDLPEEL-ANLTNLKELDLSNNQLT---DL 151

                         170
                  ....*....|....*...
gi 1767231820 392 P--LLSLKSLTHLKLSDN 407
Cdd:COG4886   152 PepLGNLTNLKSLDLSNN 169
LRR_9 pfam14580
Leucine-rich repeat;
336-407 8.18e-04

Leucine-rich repeat;


Pssm-ID: 405295 [Multi-domain]  Cd Length: 175  Bit Score: 40.13  E-value: 8.18e-04
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1767231820 336 DHCLNSLRNFPYLPNCTVLGLSNNNIKECTRILVKQVVNVEHLDLRNNFLTMNCTF-PLLSLKSLTHLKLSDN 407
Cdd:pfam14580  51 DNEIRKLDGFPLLRRLKTLLLNNNRICRIGEGLGEALPNLTELILTNNNLQELGDLdPLASLKKLTFLSLLRN 123
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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