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Conserved domains on  [gi|1767291614|ref|NP_001361951|]
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Peptidase M12B domain-containing protein [Caenorhabditis elegans]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 231-445 1.24e-72

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


:

Pssm-ID: 239801  Cd Length: 207  Bit Score: 240.99  E-value: 1.24e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767291614  231 TLEIGLFLDSKLFEHFereyiqdAEQHLLEFSLALINNVHVLYQQDTLTPNLDIVIVRYEMWRTQPSALStgvhKNGQAQ 310
Cdd:cd04273      2 YVETLVVADSKMVEFH-------HGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLL----ISGNAQ 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767291614  311 SLLDAFCRYQAHMNPGTDlTDMNHYDHGVLLTGYDI--YHTTTSVAGVAPVARMCDPLFACSLVEGLHLGRSFVLAHEMG 388
Cdd:cd04273     71 KSLKSFCRWQKKLNPPND-SDPEHHDHAILLTRQDIcrSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELG 149

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1767291614  389 HNMGMVHDGVQNQC---NKGCCLMSAVNGA--GKTTWSDCSVREFNAFLlqldESGRGNCLR 445
Cdd:cd04273    150 HVLGMPHDGDGNSCgpeGKDGHIMSPTLGAntGPFTWSKCSRRYLTSFL----DTGDGNCLL 207
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 463-531 4.00e-15

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


:

Pssm-ID: 465496  Cd Length: 68  Bit Score: 71.22  E-value: 4.00e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1767291614  463 PGQRFTADQQCSYFWGRDYKVeIPNGKamDDICRILWC--GNSGSTISTAHPALEGSWCGANKWCHKGQCT 531
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTF-CPNGD--EDVCSKLWCsnPGGSTCTTKNLPAADGTPCGNKKWCLNGKCV 68
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 64-163 6.53e-15

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


:

Pssm-ID: 460254  Cd Length: 128  Bit Score: 72.73  E-value: 6.53e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767291614   64 KFTAWNDTYHLNLRKNSRIVSPHIiSVVRHGDDDVTTYAGLRDYEQCHYQGEVKSHGNMKAAISDCGALMGSIVMEDHFL 143
Cdd:pfam01562   30 RLAAFGKKFHLHLTPNRLLLAPGF-TVTYYLDGGTGVESPPVQTDHCYYQGHVEGHPDSSVALSTCSGLRGFIRTENEEY 108

                           90       100
                   ....*....|....*....|
gi 1767291614  144 VLQTLPKRVHHLQKERHLVY 163
Cdd:pfam01562  109 LIEPLEKYSREEGGHPHVVY 128
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1324-1375 2.02e-12

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 62.99  E-value: 2.02e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1767291614  1324 WSTWSDWTPCSASCGFGVQTRDRSCSS-PEPKGGQSCSGLAHQTSLCDLPACD 1375
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1203-1254 1.46e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 57.98  E-value: 1.46e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1767291614  1203 WSLWSEWSSCSKDCGDtGHQIRNRMCSEPIPSNRGAYCSGYSFDQRPCVMDN 1254
Cdd:smart00209    1 WSEWSEWSPCSVTCGG-GVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQP 51
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 804-848 1.81e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 57.60  E-value: 1.81e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1767291614   804 WTNWDEWSSCSQSCGGGRRYRIRKCLDDK-------CDGDDLEKESCNTQKC 848
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPpqngggpCTGEDVETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1382-1432 2.12e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 57.60  E-value: 2.12e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1767291614  1382 WSAWNEWSGCMGNCGIGTRTRVRACVSPPVSDGGQPCFGRSSEITECRQSP 1432
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQP 51
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1038-1079 5.64e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 56.06  E-value: 5.64e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1767291614  1038 WSEWGPCSVTCGSGRRVRTRGC-------QEASCPEQHIQTEECNLNSC 1079
Cdd:smart00209    4 WSEWSPCSVTCGGGVQTRTRSCcspppqnGGGPCTGEDVETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1265-1315 1.57e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 54.90  E-value: 1.57e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1767291614  1265 WTDWTAWSECTDYCRNGHRSRTRFCANPKPSQGGAQCTGSDFELNPCFDPA 1315
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQP 51
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 903-949 7.77e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 52.97  E-value: 7.77e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1767291614   903 WSEWGEWTTCSATCGEGLQSRERSCRR-------GSCTEDDaSQTRRCVNGPCE 949
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqnggGPCTGED-VETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 852-895 6.97e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 50.28  E-value: 6.97e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1767291614   852 SWGDWLPCSVSCGIGFQIRERLC-------DGELCATANKQARTCNQQQCP 895
Cdd:smart00209    3 EWSEWSPCSVTCGGGVQTRTRSCcspppqnGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 707-749 1.38e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 49.51  E-value: 1.38e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1767291614   707 WEEWSSWSECSVSCGlGGREVRERKCSS------GRKCQGVSEESRPCE 749
Cdd:smart00209    1 WSEWSEWSPCSVTCG-GGVQTRTRSCCSpppqngGGPCTGEDVETRACN 48
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1148-1197 1.10e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 44.11  E-value: 1.10e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1767291614  1148 WSEWSSWSACS--CFSLTSTRRRFCQVVDPTVQG-FCAGAILEQIPCAPGSCS 1197
Cdd:smart00209    1 WSEWSEWSPCSvtCGGGVQTRTRSCCSPPPQNGGgPCTGEDVETRACNEQPCP 53
PTZ00441 super family cl25523
sporozoite surface protein 2 (SSP2); Provisional
 759-803 2.86e-04

sporozoite surface protein 2 (SSP2); Provisional


The actual alignment was detected with superfamily member PTZ00441:

Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 45.34  E-value: 2.86e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1767291614  759 GEWKEWGSCSEKCALGVQKRFRPCLTDQCSSkHLQEErpCDNEGC 803
Cdd:PTZ00441   241 GPWDEWTPCSVTCGKGTHSRSRPILHEGCTT-HMVEE--CEEEEC 282
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1085-1127 1.73e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


:

Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.95  E-value: 1.73e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1767291614  1085 WSDWSSCSKSCGqDGIQTRQKLCLFNN-----AECSSYA-ESRRCKDLP 1127
Cdd:smart00209    4 WSEWSPCSVTCG-GGVQTRTRSCCSPPpqnggGPCTGEDvETRACNEQP 51
 
Name Accession Description Interval E-value
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 231-445 1.24e-72

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 240.99  E-value: 1.24e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767291614  231 TLEIGLFLDSKLFEHFereyiqdAEQHLLEFSLALINNVHVLYQQDTLTPNLDIVIVRYEMWRTQPSALStgvhKNGQAQ 310
Cdd:cd04273      2 YVETLVVADSKMVEFH-------HGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLL----ISGNAQ 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767291614  311 SLLDAFCRYQAHMNPGTDlTDMNHYDHGVLLTGYDI--YHTTTSVAGVAPVARMCDPLFACSLVEGLHLGRSFVLAHEMG 388
Cdd:cd04273     71 KSLKSFCRWQKKLNPPND-SDPEHHDHAILLTRQDIcrSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELG 149

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1767291614  389 HNMGMVHDGVQNQC---NKGCCLMSAVNGA--GKTTWSDCSVREFNAFLlqldESGRGNCLR 445
Cdd:cd04273    150 HVLGMPHDGDGNSCgpeGKDGHIMSPTLGAntGPFTWSKCSRRYLTSFL----DTGDGNCLL 207
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 232-447 4.87e-20

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 89.67  E-value: 4.87e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767291614  232 LEIGLFLDSKLFEHFEREyiqdaEQHLLEFSLALINNVHVLYQqdtlTPNLDIVIVRYEMWRTQPSalstgVHKNGQAQS 311
Cdd:pfam01421    3 IELFIVVDKQLFQKMGSD-----TTVVRQRVFQVVNLVNSIYK----ELNIRVVLVGLEIWTDEDK-----IDVSGDAND 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767291614  312 LLDAFCRYQAHMnpgtdLTDMNHYDHGVLLTGYDIYHTTTsvaGVAPVARMCDPLFACSLVEGLH---LGRSFVLAHEMG 388
Cdd:pfam01421   69 TLRNFLKWRQEY-----LKKRKPHDVAQLLSGVEFGGTTV---GAAYVGGMCSLEYSGGVNEDHSknlESFAVTMAHELG 140

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1767291614  389 HNMGMVHDGVQNQC---NKGCCLMSAVNGA-GKTTWSDCSVREFNAFLlqldESGRGNCLRDA 447
Cdd:pfam01421  141 HNLGMQHDDFNGGCkcpPGGGCIMNPSAGSsFPRKFSNCSQEDFEQFL----TKQKGACLFNK 199
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 463-531 4.00e-15

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 71.22  E-value: 4.00e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1767291614  463 PGQRFTADQQCSYFWGRDYKVeIPNGKamDDICRILWC--GNSGSTISTAHPALEGSWCGANKWCHKGQCT 531
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTF-CPNGD--EDVCSKLWCsnPGGSTCTTKNLPAADGTPCGNKKWCLNGKCV 68
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 64-163 6.53e-15

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


Pssm-ID: 460254  Cd Length: 128  Bit Score: 72.73  E-value: 6.53e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767291614   64 KFTAWNDTYHLNLRKNSRIVSPHIiSVVRHGDDDVTTYAGLRDYEQCHYQGEVKSHGNMKAAISDCGALMGSIVMEDHFL 143
Cdd:pfam01562   30 RLAAFGKKFHLHLTPNRLLLAPGF-TVTYYLDGGTGVESPPVQTDHCYYQGHVEGHPDSSVALSTCSGLRGFIRTENEEY 108

                           90       100
                   ....*....|....*....|
gi 1767291614  144 VLQTLPKRVHHLQKERHLVY 163
Cdd:pfam01562  109 LIEPLEKYSREEGGHPHVVY 128
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1324-1375 2.02e-12

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 62.99  E-value: 2.02e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1767291614  1324 WSTWSDWTPCSASCGFGVQTRDRSCSS-PEPKGGQSCSGLAHQTSLCDLPACD 1375
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1203-1254 1.46e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 57.98  E-value: 1.46e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1767291614  1203 WSLWSEWSSCSKDCGDtGHQIRNRMCSEPIPSNRGAYCSGYSFDQRPCVMDN 1254
Cdd:smart00209    1 WSEWSEWSPCSVTCGG-GVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQP 51
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 804-848 1.81e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 57.60  E-value: 1.81e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1767291614   804 WTNWDEWSSCSQSCGGGRRYRIRKCLDDK-------CDGDDLEKESCNTQKC 848
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPpqngggpCTGEDVETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1382-1432 2.12e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 57.60  E-value: 2.12e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1767291614  1382 WSAWNEWSGCMGNCGIGTRTRVRACVSPPVSDGGQPCFGRSSEITECRQSP 1432
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQP 51
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1038-1079 5.64e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 56.06  E-value: 5.64e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1767291614  1038 WSEWGPCSVTCGSGRRVRTRGC-------QEASCPEQHIQTEECNLNSC 1079
Cdd:smart00209    4 WSEWSPCSVTCGGGVQTRTRSCcspppqnGGGPCTGEDVETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1265-1315 1.57e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 54.90  E-value: 1.57e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1767291614  1265 WTDWTAWSECTDYCRNGHRSRTRFCANPKPSQGGAQCTGSDFELNPCFDPA 1315
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQP 51
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 903-949 7.77e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 52.97  E-value: 7.77e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1767291614   903 WSEWGEWTTCSATCGEGLQSRERSCRR-------GSCTEDDaSQTRRCVNGPCE 949
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqnggGPCTGED-VETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
1325-1374 1.74e-08

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 51.65  E-value: 1.74e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1767291614 1325 STWSDWTPCSASCGFGVQTRDRSCSSPEPKGGQsCSGLAHQTSLCDLPAC 1374
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFPGGEP-CTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 852-895 6.97e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 50.28  E-value: 6.97e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1767291614   852 SWGDWLPCSVSCGIGFQIRERLC-------DGELCATANKQARTCNQQQCP 895
Cdd:smart00209    3 EWSEWSPCSVTCGGGVQTRTRSCcspppqnGGGPCTGEDVETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
1038-1079 9.69e-08

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 49.72  E-value: 9.69e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1767291614 1038 WSEWGPCSVTCGSGRRVRTRGCQE-----ASCPEQHIQTEECNLNSC 1079
Cdd:pfam00090    3 WSPWSPCSVTCGKGIQVRQRTCKSpfpggEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 707-749 1.38e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 49.51  E-value: 1.38e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1767291614   707 WEEWSSWSECSVSCGlGGREVRERKCSS------GRKCQGVSEESRPCE 749
Cdd:smart00209    1 WSEWSEWSPCSVTCG-GGVQTRTRSCCSpppqngGGPCTGEDVETRACN 48
TSP_1 pfam00090
Thrombospondin type 1 domain;
904-948 1.68e-06

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 46.26  E-value: 1.68e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1767291614  904 SEWGEWTTCSATCGEGLQSRERSC-----RRGSCTEDDAsQTRRCVNGPC 948
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCkspfpGGEPCTGDDI-ETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1148-1197 1.10e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 44.11  E-value: 1.10e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1767291614  1148 WSEWSSWSACS--CFSLTSTRRRFCQVVDPTVQG-FCAGAILEQIPCAPGSCS 1197
Cdd:smart00209    1 WSEWSEWSPCSvtCGGGVQTRTRSCCSPPPQNGGgPCTGEDVETRACNEQPCP 53
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 707-763 1.18e-05

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 49.17  E-value: 1.18e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767291614  707 WEEWSSWSECSVSCGLGGR-EVRERKCS--SGRKCQGVSEESRPCEGVLRDCEEFGEWKE 763
Cdd:PTZ00087   233 YTEWGEWSNCSMECDHPDNvQIRERKCAhpSGDCFKGDLKETRPCQVPLPPCNSLFEHKE 292
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 805-848 1.38e-05

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 43.81  E-value: 1.38e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1767291614  805 TNWDEWSSCSQSCGGGRRYRIRKCLDDKCDG-----DDLEKESCNTQKC 848
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVEPQNGgrpcpELLERRPCNLPPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
1266-1311 1.46e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 43.56  E-value: 1.46e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1767291614 1266 TDWTAWSECTDYCRNGHRSRTRFCANPKPsqGGAQCTGSDFELNPC 1311
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQAC 44
TSP_1 pfam00090
Thrombospondin type 1 domain;
1204-1253 1.58e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 43.56  E-value: 1.58e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1767291614 1204 SLWSEWSSCSKDCGDtGHQIRNRMCSEPIPSnrGAYCSGYSFDQRPCVMD 1253
Cdd:pfam00090    1 SPWSPWSPCSVTCGK-GIQVRQRTCKSPFPG--GEPCTGDDIETQACKMD 47
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 1038-1080 1.71e-05

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 49.19  E-value: 1.71e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1767291614 1038 WSEWGPCSVTCGSGRRVRTRGCQEASCpEQHIQtEECNLNSCL 1080
Cdd:PTZ00441   243 WDEWTPCSVTCGKGTHSRSRPILHEGC-TTHMV-EECEEEECP 283
TSP_1 pfam00090
Thrombospondin type 1 domain;
853-894 1.92e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 43.18  E-value: 1.92e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1767291614  853 WGDWLPCSVSCGIGFQIRERLCD-----GELCATANKQARTCNQQQC 894
Cdd:pfam00090    3 WSPWSPCSVTCGKGIQVRQRTCKspfpgGEPCTGDDIETQACKMDKC 49
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 903-944 8.83e-05

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 46.48  E-value: 8.83e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1767291614  903 WSEWGEWTTCSATCG--EGLQSRERSC--RRGSCTEDDASQTRRCV 944
Cdd:PTZ00087   233 YTEWGEWSNCSMECDhpDNVQIRERKCahPSGDCFKGDLKETRPCQ 278
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1383-1418 1.64e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 40.73  E-value: 1.64e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1767291614 1383 SAWNEWSGCMGNCGIGTRTRVRACVSPPvSDGGQPC 1418
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVEP-QNGGRPC 38
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 759-803 2.86e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 45.34  E-value: 2.86e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1767291614  759 GEWKEWGSCSEKCALGVQKRFRPCLTDQCSSkHLQEErpCDNEGC 803
Cdd:PTZ00441   241 GPWDEWTPCSVTCGKGTHSRSRPILHEGCTT-HMVEE--CEEEEC 282
TSP_1 pfam00090
Thrombospondin type 1 domain;
709-749 3.56e-04

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 39.71  E-value: 3.56e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1767291614  709 EWSSWSECSVSCGLGGReVRERKCSS----GRKCQGVSEESRPCE 749
Cdd:pfam00090    2 PWSPWSPCSVTCGKGIQ-VRQRTCKSpfpgGEPCTGDDIETQACK 45
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 807-848 9.60e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 43.80  E-value: 9.60e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1767291614  807 WDEWSSCSQSCGGGRRYRIRKCLDDKCDgDDLEKEsCNTQKC 848
Cdd:PTZ00441   243 WDEWTPCSVTCGKGTHSRSRPILHEGCT-THMVEE-CEEEEC 282
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1085-1127 1.73e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.95  E-value: 1.73e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1767291614  1085 WSDWSSCSKSCGqDGIQTRQKLCLFNN-----AECSSYA-ESRRCKDLP 1127
Cdd:smart00209    4 WSEWSPCSVTCG-GGVQTRTRSCCSPPpqnggGPCTGEDvETRACNEQP 51
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 759-803 2.10e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 37.64  E-value: 2.10e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1767291614  759 GEWKEWGSCSEKCALGVQKRFR-----------PCltdqcssKHLQEERPCDNEGC 803
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRtvivepqnggrPC-------PELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 759-803 2.32e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.57  E-value: 2.32e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1767291614   759 GEWKEWGSCSEKCALGVQKRFRPCLTD-------QCSSKHLqEERPCDNEGC 803
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPppqngggPCTGEDV-ETRACNEQPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1085-1127 2.80e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 37.26  E-value: 2.80e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1767291614 1085 WSDWSSCSKSCGqDGIQTRQKLCL----FNNAECSSYAESRRCKDLP 1127
Cdd:pfam19028    6 WSEWSECSVTCG-GGVQTRTRTVIvepqNGGRPCPELLERRPCNLPP 51
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 1085-1132 4.48e-03

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 41.08  E-value: 4.48e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1767291614 1085 WSDWSSCSKSCGQ-DGIQTRQKLCLFNNAEC--SSYAESRRCK-DLPSCSSI 1132
Cdd:PTZ00087   236 WGEWSNCSMECDHpDNVQIRERKCAHPSGDCfkGDLKETRPCQvPLPPCNSL 287
 
Name Accession Description Interval E-value
ZnMc_ADAMTS_like cd04273
Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) ...
 231-445 1.24e-72

Zinc-dependent metalloprotease, ADAMTS_like subgroup. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions. This particular subfamily represents domain architectures that combine ADAM-like metalloproteinases with thrombospondin type-1 repeats. ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) proteinases are inhibited by TIMPs (tissue inhibitors of metalloproteinases), and they play roles in coagulation, angiogenesis, development and progression of arthritis. They hydrolyze the von Willebrand factor precursor and various components of the extracellular matrix.


Pssm-ID: 239801  Cd Length: 207  Bit Score: 240.99  E-value: 1.24e-72
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767291614  231 TLEIGLFLDSKLFEHFereyiqdAEQHLLEFSLALINNVHVLYQQDTLTPNLDIVIVRYEMWRTQPSALStgvhKNGQAQ 310
Cdd:cd04273      2 YVETLVVADSKMVEFH-------HGEDLEHYILTLMNIVASLYKDPSLGNSINIVVVRLIVLEDEESGLL----ISGNAQ 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767291614  311 SLLDAFCRYQAHMNPGTDlTDMNHYDHGVLLTGYDI--YHTTTSVAGVAPVARMCDPLFACSLVEGLHLGRSFVLAHEMG 388
Cdd:cd04273     71 KSLKSFCRWQKKLNPPND-SDPEHHDHAILLTRQDIcrSNGNCDTLGLAPVGGMCSPSRSCSINEDTGLSSAFTIAHELG 149

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1767291614  389 HNMGMVHDGVQNQC---NKGCCLMSAVNGA--GKTTWSDCSVREFNAFLlqldESGRGNCLR 445
Cdd:cd04273    150 HVLGMPHDGDGNSCgpeGKDGHIMSPTLGAntGPFTWSKCSRRYLTSFL----DTGDGNCLL 207
ZnMc_adamalysin_II_like cd04269
Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom ...
 232-446 2.27e-25

Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239797 [Multi-domain]  Cd Length: 194  Bit Score: 105.00  E-value: 2.27e-25
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767291614  232 LEIGLFLDSKLFEHFEREyiqdaEQHLLEFSLALINNVHVLYQQDtltpNLDIVIVRYEMWRTQ-PSALStgvhknGQAQ 310
Cdd:cd04269      3 VELVVVVDNSLYKKYGSN-----LSKVRQRVIEIVNIVDSIYRPL----NIRVVLVGLEIWTDKdKISVS------GDAG 67

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767291614  311 SLLDAFCRYQAhmnpgTDLTDMNHYDHGVLLTGYDIYHTTtsvAGVAPVARMCDPLFACSLVEGLH---LGRSFVLAHEM 387
Cdd:cd04269     68 ETLNRFLDWKR-----SNLLPRKPHDNAQLLTGRDFDGNT---VGLAYVGGMCSPKYSGGVVQDHSrnlLLFAVTMAHEL 139

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1767291614  388 GHNMGMVHDGVQNQCNKGCCLMSAVNGAGKTTWSDCSVREFNAFLLQldesGRGNCLRD 446
Cdd:cd04269    140 GHNLGMEHDDGGCTCGRSTCIMAPSPSSLTDAFSNCSYEDYQKFLSR----GGGQCLLN 194
Reprolysin pfam01421
Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that ...
 232-447 4.87e-20

Reprolysin (M12B) family zinc metalloprotease; The members of this family are enzymes that cleave peptides. These proteases require zinc for catalysis. Members of this family are also known as adamalysins. Most members of this family are snake venom endopeptidases, but there are also some mammalian proteins such as Swiss:P78325, and fertilin. Fertilin and closely related proteins appear to not have some active site residues and may not be active enzymes.


Pssm-ID: 426256 [Multi-domain]  Cd Length: 200  Bit Score: 89.67  E-value: 4.87e-20
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767291614  232 LEIGLFLDSKLFEHFEREyiqdaEQHLLEFSLALINNVHVLYQqdtlTPNLDIVIVRYEMWRTQPSalstgVHKNGQAQS 311
Cdd:pfam01421    3 IELFIVVDKQLFQKMGSD-----TTVVRQRVFQVVNLVNSIYK----ELNIRVVLVGLEIWTDEDK-----IDVSGDAND 68

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767291614  312 LLDAFCRYQAHMnpgtdLTDMNHYDHGVLLTGYDIYHTTTsvaGVAPVARMCDPLFACSLVEGLH---LGRSFVLAHEMG 388
Cdd:pfam01421   69 TLRNFLKWRQEY-----LKKRKPHDVAQLLSGVEFGGTTV---GAAYVGGMCSLEYSGGVNEDHSknlESFAVTMAHELG 140

                          170       180       190       200       210       220
                   ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1767291614  389 HNMGMVHDGVQNQC---NKGCCLMSAVNGA-GKTTWSDCSVREFNAFLlqldESGRGNCLRDA 447
Cdd:pfam01421  141 HNLGMQHDDFNGGCkcpPGGGCIMNPSAGSsFPRKFSNCSQEDFEQFL----TKQKGACLFNK 199
ZnMc_ADAM_like cd04267
Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ...
 244-432 5.68e-19

Zinc-dependent metalloprotease, ADAM_like or reprolysin_like subgroup. The adamalysin_like or ADAM family of metalloproteases contains proteolytic domains from snake venoms, proteases from the mammalian reproductive tract, and the tumor necrosis factor alpha convertase, TACE. ADAMs (A Disintegrin And Metalloprotease) are glycoproteins, which play roles in cell signaling, cell fusion, and cell-cell interactions.


Pssm-ID: 239795  Cd Length: 192  Bit Score: 86.32  E-value: 5.68e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767291614  244 EHFEREYIQDAEQHLLEFSLALINNVHVLYQQDTLTPNLDIVIVRYEMWRTQPSALSTGvhknGQAQSLLDAFCRYQAhm 323
Cdd:cd04267     10 DHRMVSYFNSDENILQAYITELINIANSIYRSTNLRLGIRISLEGLQILKGEQFAPPID----SDASNTLNSFSFWRA-- 83

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767291614  324 npgtdlTDMNHYDHGVLLTGYDIYHTTTsvAGVAPVARMCDPLFACSLVE--GLHLGRSFVLAHEMGHNMGMVHDG---- 397
Cdd:cd04267     84 ------EGPIRHDNAVLLTAQDFIEGDI--LGLAYVGSMCNPYSSVGVVEdtGFTLLTALTMAHELGHNLGAEHDGgdel 155

                          170       180       190
                   ....*....|....*....|....*....|....*.
gi 1767291614  398 VQNQCNKGCCLMS-AVNGAGKTTWSDCSVREFNAFL 432
Cdd:cd04267    156 AFECDGGGNYIMApVDSGLNSYRFSQCSIGSIREFL 191
ADAMTS_CR_2 pfam17771
ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS ...
 463-531 4.00e-15

ADAMTS cysteine-rich domain 2; This cysteine rich domain is found in a variety of ADAMTS peptidases (A Disintegrin and Metalloproteinase with Thrombospondin Motifs) which is closely related to the ADAM family (pfam08516). Members of the ADAM-TS family have been implicated in a range of diseases. For instance, members of this family have been found to participate directly in processes in the central nervous system (CNS) such as the regulation of brain plasticity.


Pssm-ID: 465496  Cd Length: 68  Bit Score: 71.22  E-value: 4.00e-15
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1767291614  463 PGQRFTADQQCSYFWGRDYKVeIPNGKamDDICRILWC--GNSGSTISTAHPALEGSWCGANKWCHKGQCT 531
Cdd:pfam17771    1 PGQLYSADEQCRLIFGPGSTF-CPNGD--EDVCSKLWCsnPGGSTCTTKNLPAADGTPCGNKKWCLNGKCV 68
Pep_M12B_propep pfam01562
Reprolysin family propeptide; This region is the propeptide for members of peptidase family ...
 64-163 6.53e-15

Reprolysin family propeptide; This region is the propeptide for members of peptidase family M12B. The propeptide contains a sequence motif similar to the "cysteine switch" of the matrixins. This motif is found at the C terminus of the alignment but is not well aligned.


Pssm-ID: 460254  Cd Length: 128  Bit Score: 72.73  E-value: 6.53e-15
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767291614   64 KFTAWNDTYHLNLRKNSRIVSPHIiSVVRHGDDDVTTYAGLRDYEQCHYQGEVKSHGNMKAAISDCGALMGSIVMEDHFL 143
Cdd:pfam01562   30 RLAAFGKKFHLHLTPNRLLLAPGF-TVTYYLDGGTGVESPPVQTDHCYYQGHVEGHPDSSVALSTCSGLRGFIRTENEEY 108

                           90       100
                   ....*....|....*....|
gi 1767291614  144 VLQTLPKRVHHLQKERHLVY 163
Cdd:pfam01562  109 LIEPLEKYSREEGGHPHVVY 128
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1324-1375 2.02e-12

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 62.99  E-value: 2.02e-12
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1767291614  1324 WSTWSDWTPCSASCGFGVQTRDRSCSS-PEPKGGQSCSGLAHQTSLCDLPACD 1375
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpPPQNGGGPCTGEDVETRACNEQPCP 53
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1203-1254 1.46e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 57.98  E-value: 1.46e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1767291614  1203 WSLWSEWSSCSKDCGDtGHQIRNRMCSEPIPSNRGAYCSGYSFDQRPCVMDN 1254
Cdd:smart00209    1 WSEWSEWSPCSVTCGG-GVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQP 51
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 804-848 1.81e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 57.60  E-value: 1.81e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1767291614   804 WTNWDEWSSCSQSCGGGRRYRIRKCLDDK-------CDGDDLEKESCNTQKC 848
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPpqngggpCTGEDVETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1382-1432 2.12e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 57.60  E-value: 2.12e-10
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1767291614  1382 WSAWNEWSGCMGNCGIGTRTRVRACVSPPVSDGGQPCFGRSSEITECRQSP 1432
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQP 51
ZnMc_salivary_gland_MPs cd04272
Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary ...
 230-432 4.24e-10

Zinc-dependent metalloprotease, salivary_gland_MPs. Metalloproteases secreted by the salivary glands of arthropods.


Pssm-ID: 239800  Cd Length: 220  Bit Score: 61.21  E-value: 4.24e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767291614  230 ITLEIGLFLDSKLFEHFEREyiqdaeQHLLEFSLALINNVHVLYQqDTLTPNLDIVIVRYEMWRTQPSALstgVHKNGQA 309
Cdd:cd04272      1 VYPELFVVVDYDHQSEFFSN------EQLIRYLAVMVNAANLRYR-DLKSPRIRLLLVGITISKDPDFEP---YIHPINY 70

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767291614  310 QSLLDAFC--RYQAHMNPGTDLTDmnhYDHGVLLTGYDIYHT-----TTSVAGVAPVARMCDPLFAcSLVE-------GL 375
Cdd:cd04272     71 GYIDAAETleNFNEYVKKKRDYFN---PDVVFLVTGLDMSTYsggslQTGTGGYAYVGGACTENRV-AMGEdtpgsyyGV 146

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767291614  376 HlgrsfVLAHEMGHNMGMVHDG------VQNQCNKGCC------LMS-AVNGAGKTTWSDCSVREFNAFL 432
Cdd:cd04272    147 Y-----TMTHELAHLLGAPHDGspppswVKGHPGSLDCpwddgyIMSyVVNGERQYRFSQCSQRQIRNVF 211
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1038-1079 5.64e-10

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 56.06  E-value: 5.64e-10
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1767291614  1038 WSEWGPCSVTCGSGRRVRTRGC-------QEASCPEQHIQTEECNLNSC 1079
Cdd:smart00209    4 WSEWSPCSVTCGGGVQTRTRSCcspppqnGGGPCTGEDVETRACNEQPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1265-1315 1.57e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 54.90  E-value: 1.57e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1767291614  1265 WTDWTAWSECTDYCRNGHRSRTRFCANPKPSQGGAQCTGSDFELNPCFDPA 1315
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSPPPQNGGGPCTGEDVETRACNEQP 51
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 903-949 7.77e-09

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 52.97  E-value: 7.77e-09
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|....
gi 1767291614   903 WSEWGEWTTCSATCGEGLQSRERSCRR-------GSCTEDDaSQTRRCVNGPCE 949
Cdd:smart00209    1 WSEWSEWSPCSVTCGGGVQTRTRSCCSpppqnggGPCTGED-VETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
1325-1374 1.74e-08

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 51.65  E-value: 1.74e-08
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1767291614 1325 STWSDWTPCSASCGFGVQTRDRSCSSPEPKGGQsCSGLAHQTSLCDLPAC 1374
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFPGGEP-CTGDDIETQACKMDKC 49
Reprolysin_5 pfam13688
Metallo-peptidase family M12;
263-421 5.42e-08

Metallo-peptidase family M12;


Pssm-ID: 372673  Cd Length: 191  Bit Score: 54.35  E-value: 5.42e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767291614  263 LALINNVHVLYQQDTltpNLDIVIVRYEMW-RTQPSALSTGVHKNgqAQSLLDAFcryqahmnpgTDLTDMNH---YDHG 338
Cdd:pfam13688   29 INMVNTASNVYERDF---NISLGLVNLTISdSTCPYTPPACSTGD--SSDRLSEF----------QDFSAWRGtqnDDLA 93

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767291614  339 VLLTgydiyHTTTSVAGVAPVARMC--DPLFACSLVEGLHLGRS------FVLAHEMGHNMGMVHDGvQNQCNKGCC--- 407
Cdd:pfam13688   94 YLFL-----MTNCSGGGLAWLGQLCnsGSAGSVSTRVSGNNVVVstatewQVFAHEIGHNFGAVHDC-DSSTSSQCCpps 167

                          170       180
                   ....*....|....*....|....
gi 1767291614  408 ----------LMSAVNGAGKTTWS 421
Cdd:pfam13688  168 nstcpaggryIMNPSSSPNSTDFS 191
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 852-895 6.97e-08

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 50.28  E-value: 6.97e-08
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|.
gi 1767291614   852 SWGDWLPCSVSCGIGFQIRERLC-------DGELCATANKQARTCNQQQCP 895
Cdd:smart00209    3 EWSEWSPCSVTCGGGVQTRTRSCcspppqnGGGPCTGEDVETRACNEQPCP 53
TSP_1 pfam00090
Thrombospondin type 1 domain;
1038-1079 9.69e-08

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 49.72  E-value: 9.69e-08
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1767291614 1038 WSEWGPCSVTCGSGRRVRTRGCQE-----ASCPEQHIQTEECNLNSC 1079
Cdd:pfam00090    3 WSPWSPCSVTCGKGIQVRQRTCKSpfpggEPCTGDDIETQACKMDKC 49
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 707-749 1.38e-07

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 49.51  E-value: 1.38e-07
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1767291614   707 WEEWSSWSECSVSCGlGGREVRERKCSS------GRKCQGVSEESRPCE 749
Cdd:smart00209    1 WSEWSEWSPCSVTCG-GGVQTRTRSCCSpppqngGGPCTGEDVETRACN 48
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1038-1079 2.24e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 48.81  E-value: 2.24e-07
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1767291614 1038 WSEWGPCSVTCGSGRRVRTR---------GcqeASCPEQHiQTEECNLNSC 1079
Cdd:pfam19028    6 WSEWSECSVTCGGGVQTRTRtvivepqngG---RPCPELL-ERRPCNLPPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
904-948 1.68e-06

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 46.26  E-value: 1.68e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1767291614  904 SEWGEWTTCSATCGEGLQSRERSC-----RRGSCTEDDAsQTRRCVNGPC 948
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCkspfpGGEPCTGDDI-ETQACKMDKC 49
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1325-1374 1.86e-06

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 46.12  E-value: 1.86e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1767291614 1325 STWSDWTPCSASCGFGVQTRDRSCSSPEPKGGQSCSGLaHQTSLCDLPAC 1374
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVEPQNGGRPCPEL-LERRPCNLPPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 904-948 2.73e-06

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 45.73  E-value: 2.73e-06
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1767291614  904 SEWGEWTTCSATCGEGLQSRERSCRR------GSCTEDdaSQTRRCVNGPC 948
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVepqnggRPCPEL--LERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1148-1197 1.10e-05

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 44.11  E-value: 1.10e-05
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|...
gi 1767291614  1148 WSEWSSWSACS--CFSLTSTRRRFCQVVDPTVQG-FCAGAILEQIPCAPGSCS 1197
Cdd:smart00209    1 WSEWSEWSPCSvtCGGGVQTRTRSCCSPPPQNGGgPCTGEDVETRACNEQPCP 53
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 707-763 1.18e-05

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 49.17  E-value: 1.18e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767291614  707 WEEWSSWSECSVSCGLGGR-EVRERKCS--SGRKCQGVSEESRPCEGVLRDCEEFGEWKE 763
Cdd:PTZ00087   233 YTEWGEWSNCSMECDHPDNvQIRERKCAhpSGDCFKGDLKETRPCQVPLPPCNSLFEHKE 292
Reprolysin_3 pfam13582
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 264-396 1.38e-05

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 463926 [Multi-domain]  Cd Length: 122  Bit Score: 45.82  E-value: 1.38e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767291614  264 ALINNVHVLYQQDTltpNLDIVIVRYEMWR--TQPSALSTGVHKNGQAQSLLDafcryqahmnpgtdlTDMNH--YDHGV 339
Cdd:pfam13582    5 SLVNRANTIYERDL---GIRLQLAAIIITTsaDTPYTSSDALEILDELQEVND---------------TRIGQygYDLGH 66

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767291614  340 LLTGYDIYhtttSVAGVAPVARMCDPLFACSLVEGLHLGRSF---VLAHEMGHNMGMVHD 396
Cdd:pfam13582   67 LFTGRDGG----GGGGIAYVGGVCNSGSKFGVNSGSGPVGDTgadTFAHEIGHNFGLNHT 122
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 805-848 1.38e-05

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 43.81  E-value: 1.38e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1767291614  805 TNWDEWSSCSQSCGGGRRYRIRKCLDDKCDG-----DDLEKESCNTQKC 848
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVEPQNGgrpcpELLERRPCNLPPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
1266-1311 1.46e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 43.56  E-value: 1.46e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1767291614 1266 TDWTAWSECTDYCRNGHRSRTRFCANPKPsqGGAQCTGSDFELNPC 1311
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPFP--GGEPCTGDDIETQAC 44
TSP_1 pfam00090
Thrombospondin type 1 domain;
1204-1253 1.58e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 43.56  E-value: 1.58e-05
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1767291614 1204 SLWSEWSSCSKDCGDtGHQIRNRMCSEPIPSnrGAYCSGYSFDQRPCVMD 1253
Cdd:pfam00090    1 SPWSPWSPCSVTCGK-GIQVRQRTCKSPFPG--GEPCTGDDIETQACKMD 47
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 1038-1080 1.71e-05

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 49.19  E-value: 1.71e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1767291614 1038 WSEWGPCSVTCGSGRRVRTRGCQEASCpEQHIQtEECNLNSCL 1080
Cdd:PTZ00441   243 WDEWTPCSVTCGKGTHSRSRPILHEGC-TTHMV-EECEEEECP 283
TSP_1 pfam00090
Thrombospondin type 1 domain;
853-894 1.92e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 43.18  E-value: 1.92e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1767291614  853 WGDWLPCSVSCGIGFQIRERLCD-----GELCATANKQARTCNQQQC 894
Cdd:pfam00090    3 WSPWSPCSVTCGKGIQVRQRTCKspfpgGEPCTGDDIETQACKMDKC 49
TSP_1 pfam00090
Thrombospondin type 1 domain;
805-848 2.27e-05

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 43.18  E-value: 2.27e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*....
gi 1767291614  805 TNWDEWSSCSQSCGGGRRYRIRKC-----LDDKCDGDDLEKESCNTQKC 848
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCkspfpGGEPCTGDDIETQACKMDKC 49
ZnMc cd00203
Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major ...
 345-424 7.60e-05

Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which are involved in vertebrate development and disease.


Pssm-ID: 238124 [Multi-domain]  Cd Length: 167  Bit Score: 44.82  E-value: 7.60e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767291614  345 DIYHTTTSV------AGVAPVARMCDPLFACSLVE----GLHLGRsFVLAHEMGHNMGMVHDGVQNQCNKGC-------- 406
Cdd:cd00203     53 DIAILVTRQdfdggtGGWAYLGRVCDSLRGVGVLQdnqsGTKEGA-QTIAHELGHALGFYHDHDRKDRDDYPtiddtlna 131

                           90       100
                   ....*....|....*....|....*...
gi 1767291614  407 ------CLMSAV----NGAGKTTWSDCS 424
Cdd:cd00203    132 edddyySVMSYTkgsfSDGQRKDFSQCD 159
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 903-944 8.83e-05

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 46.48  E-value: 8.83e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1767291614  903 WSEWGEWTTCSATCG--EGLQSRERSC--RRGSCTEDDASQTRRCV 944
Cdd:PTZ00087   233 YTEWGEWSNCSMECDhpDNVQIRERKCahPSGDCFKGDLKETRPCQ 278
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1383-1418 1.64e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 40.73  E-value: 1.64e-04
                           10        20        30
                   ....*....|....*....|....*....|....*.
gi 1767291614 1383 SAWNEWSGCMGNCGIGTRTRVRACVSPPvSDGGQPC 1418
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRTVIVEP-QNGGRPC 38
TSP_1 pfam00090
Thrombospondin type 1 domain;
1383-1432 2.22e-04

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 40.09  E-value: 2.22e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1767291614 1383 SAWNEWSGCMGNCGIGTRTRVRACVSPPvsDGGQPCFGRSSEITECRQSP 1432
Cdd:pfam00090    1 SPWSPWSPCSVTCGKGIQVRQRTCKSPF--PGGEPCTGDDIETQACKMDK 48
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 759-803 2.86e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 45.34  E-value: 2.86e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1767291614  759 GEWKEWGSCSEKCALGVQKRFRPCLTDQCSSkHLQEErpCDNEGC 803
Cdd:PTZ00441   241 GPWDEWTPCSVTCGKGTHSRSRPILHEGCTT-HMVEE--CEEEEC 282
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 848-894 3.37e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 39.96  E-value: 3.37e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|...
gi 1767291614  848 CISQSWGDWLPCSVSCGIGFQIRER------LCDGELCaTANKQARTCNQQQC 894
Cdd:pfam19028    1 CVVSEWSEWSECSVTCGGGVQTRTRtvivepQNGGRPC-PELLERRPCNLPPC 52
TSP_1 pfam00090
Thrombospondin type 1 domain;
709-749 3.56e-04

Thrombospondin type 1 domain;


Pssm-ID: 459668 [Multi-domain]  Cd Length: 49  Bit Score: 39.71  E-value: 3.56e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 1767291614  709 EWSSWSECSVSCGLGGReVRERKCSS----GRKCQGVSEESRPCE 749
Cdd:pfam00090    2 PWSPWSPCSVTCGKGIQ-VRQRTCKSpfpgGEPCTGDDIETQACK 45
Reprolysin_2 pfam13574
Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the ...
 382-425 4.71e-04

Metallo-peptidase family M12B Reprolysin-like; This zinc-binding metallo-peptidase has the characteriztic binding motif HExxGHxxGxxH of Reprolysin-like peptidases of family M12B.


Pssm-ID: 372637  Cd Length: 193  Bit Score: 43.00  E-value: 4.71e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*....
gi 1767291614  382 VLAHEMGHNMGMVHD--GVQNQC-------------NKGCCLMSAVNGAGKTTWSDCSV 425
Cdd:pfam13574  127 VVAHEVGHNFGATHDcdGSQYASsgcernaatsvcsANGSFIMNPASKSNNDLFSPCSI 185
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1204-1254 5.79e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 39.18  E-value: 5.79e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1767291614 1204 SLWSEWSSCSKDCGdTGHQIRNRMCSEPiPSNRGAYCSGySFDQRPCVMDN 1254
Cdd:pfam19028    4 SEWSEWSECSVTCG-GGVQTRTRTVIVE-PQNGGRPCPE-LLERRPCNLPP 51
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 709-750 6.20e-04

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 39.18  E-value: 6.20e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1767291614  709 EWSSWSECSVSCGLG----GREVRERKCSSGRKCqGVSEESRPCEG 750
Cdd:pfam19028    5 EWSEWSECSVTCGGGvqtrTRTVIVEPQNGGRPC-PELLERRPCNL 49
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 906-948 6.54e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 44.18  E-value: 6.54e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 1767291614  906 WGEWTTCSATCGEGLQSRERSCRRGSCTEDDASQtrrCVNGPC 948
Cdd:PTZ00441   243 WDEWTPCSVTCGKGTHSRSRPILHEGCTTHMVEE---CEEEEC 282
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 1329-1374 7.74e-04

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 38.97  E-value: 7.74e-04
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|.
gi 1767291614 1329 DWTPCSASCGFGVQTRDRSC---SSPEPKGGQSCSGLA--HQTSLCDLPAC 1374
Cdd:pfam19030    5 PWGECSVTCGGGVQTRLVQCvqkGGGSIVPDSECSAQKkpPETQSCNLKPC 55
ZnMc_ADAM_fungal cd04271
Zinc-dependent metalloprotease, ADAM_fungal subgroup. The adamalysin_like or ADAM (A ...
 382-444 8.32e-04

Zinc-dependent metalloprotease, ADAM_fungal subgroup. The adamalysin_like or ADAM (A Disintegrin And Metalloprotease) family of metalloproteases are integral membrane proteases acting on a variety of extracellular targets. They are involved in shedding soluble peptides or proteins from the cell surface. This subfamily contains fungal ADAMs, whose precise function has yet to be determined.


Pssm-ID: 239799 [Multi-domain]  Cd Length: 228  Bit Score: 42.79  E-value: 8.32e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767291614  382 VLAHEMGHNMGMVHDGVQNQCNKG------CC-------------LMSAVNGAGKTTWSDCSVREFNAFLLQldESGRGN 442
Cdd:cd04271    148 VFAHEIGHTFGAVHDCTSGTCSDGsvgsqqCCplststcdangqyIMNPSSSSGITEFSPCTIGNICSLLGR--NPVRTS 225


                   ..
gi 1767291614  443 CL 444
Cdd:cd04271    226 CL 227
PTZ00441 PTZ00441
sporozoite surface protein 2 (SSP2); Provisional
 807-848 9.60e-04

sporozoite surface protein 2 (SSP2); Provisional


Pssm-ID: 240420 [Multi-domain]  Cd Length: 576  Bit Score: 43.80  E-value: 9.60e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1767291614  807 WDEWSSCSQSCGGGRRYRIRKCLDDKCDgDDLEKEsCNTQKC 848
Cdd:PTZ00441   243 WDEWTPCSVTCGKGTHSRSRPILHEGCT-THMVEE-CEEEEC 282
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 1085-1127 1.73e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.95  E-value: 1.73e-03
                            10        20        30        40
                    ....*....|....*....|....*....|....*....|....*....
gi 1767291614  1085 WSDWSSCSKSCGqDGIQTRQKLCLFNN-----AECSSYA-ESRRCKDLP 1127
Cdd:smart00209    4 WSEWSPCSVTCG-GGVQTRTRSCCSPPpqnggGPCTGEDvETRACNEQP 51
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 854-894 2.01e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 37.82  E-value: 2.01e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1767291614  854 GDWLPCSVSCGIGFQIRERLC---------DGELCATANK--QARTCNQQQC 894
Cdd:pfam19030    4 GPWGECSVTCGGGVQTRLVQCvqkgggsivPDSECSAQKKppETQSCNLKPC 55
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 759-803 2.10e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 37.64  E-value: 2.10e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1767291614  759 GEWKEWGSCSEKCALGVQKRFR-----------PCltdqcssKHLQEERPCDNEGC 803
Cdd:pfam19028    4 SEWSEWSECSVTCGGGVQTRTRtvivepqnggrPC-------PELLERRPCNLPPC 52
TSP1 smart00209
Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.
 759-803 2.32e-03

Thrombospondin type 1 repeats; Type 1 repeats in thrombospondin-1 bind and activate TGF-beta.


Pssm-ID: 214559 [Multi-domain]  Cd Length: 53  Bit Score: 37.57  E-value: 2.32e-03
                            10        20        30        40        50
                    ....*....|....*....|....*....|....*....|....*....|..
gi 1767291614   759 GEWKEWGSCSEKCALGVQKRFRPCLTD-------QCSSKHLqEERPCDNEGC 803
Cdd:smart00209    2 SEWSEWSPCSVTCGGGVQTRTRSCCSPppqngggPCTGEDV-ETRACNEQPC 52
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 1085-1127 2.80e-03

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 37.26  E-value: 2.80e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*..
gi 1767291614 1085 WSDWSSCSKSCGqDGIQTRQKLCL----FNNAECSSYAESRRCKDLP 1127
Cdd:pfam19028    6 WSEWSECSVTCG-GGVQTRTRTVIvepqNGGRPCPELLERRPCNLPP 51
TSP1_ADAMTS pfam19030
Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found ...
 810-848 4.38e-03

Thrombospondin type 1 domain; This subfamily of thrombospondin type 1 repeats are mainly found in ADAMTS proteins.


Pssm-ID: 465950 [Multi-domain]  Cd Length: 55  Bit Score: 36.66  E-value: 4.38e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|
gi 1767291614  810 WSSCSQSCGGGRRYRIRKC---------LDDKCDGDDL--EKESCNTQKC 848
Cdd:pfam19030    6 WGECSVTCGGGVQTRLVQCvqkgggsivPDSECSAQKKppETQSCNLKPC 55
PTZ00087 PTZ00087
thrombosponding-related protein; Provisional
 1085-1132 4.48e-03

thrombosponding-related protein; Provisional


Pssm-ID: 185438  Cd Length: 340  Bit Score: 41.08  E-value: 4.48e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|..
gi 1767291614 1085 WSDWSSCSKSCGQ-DGIQTRQKLCLFNNAEC--SSYAESRRCK-DLPSCSSI 1132
Cdd:PTZ00087   236 WGEWSNCSMECDHpDNVQIRERKCAHPSGDCfkGDLKETRPCQvPLPPCNSL 287
TSP1_CCN pfam19035
CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in ...
 1086-1127 7.81e-03

CCN3 Nov like TSP1 domain; This entry represents a sub-type of TSP1 domains found in matricellular CCN proteins that have an alternative disulphide binding pattern compared to the canonical TSP1 domains.


Pssm-ID: 465952  Cd Length: 44  Bit Score: 35.77  E-value: 7.81e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|..
gi 1767291614 1086 SDWSSCSKSCGQdGIQTRQKlclFNNAECSSYAESRRCKDLP 1127
Cdd:pfam19035    6 TEWSPCSKTCGM-GVSTRVS---NDNAECKLVTETRLCQLRP 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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