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Conserved domains on  [gi|1767231573|ref|NP_001362011|]
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Protein KATNIP homolog [Caenorhabditis elegans]

Protein Classification

KIAA0556 family protein( domain architecture ID 143229)

KIAA0556 family protein is a DUF4457 domain-containing protein; similar to Caenorhabditis elegans protein KATNIP homolog that may regulate ciliary A-tubule number and, along with arl-13, controls cilium integrity

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DUF4457 super family cl20613
Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is ...
 263-548 2.47e-88

Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.


The actual alignment was detected with superfamily member pfam14652:

Pssm-ID: 464238  Cd Length: 323  Bit Score: 275.69  E-value: 2.47e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231573 263 IELLSNWGMDGLIGLTGLELVDEHSQLI--DESQYTVTTSDGNS------DLSK--KLFNGRNLTRDPHDMWLVDFDSKN 332
Cdd:pfam14652   1 LNFLSTWGDRHYLGLTGLEVLGEDGKAIpiQLSNITASPRDLNDlpgysgDYRTldKLIDGTNVTTDDEHMWLIPFSPGK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231573 333 FTTISITFHDNVALKAISVWNYNASFELSYAGVKAAKIYINGKLIKNV---LLRKATGFVYFDYVQDVVLD------PNN 403
Cdd:pfam14652  81 EHTLTIDFGKPTSISGLRIWNYNKSLEDTYRGAKKVSVSLDGVVISPPegfLLRKAPGNCHFDFAQTISFPnvdkvnPPS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231573 404 TERDFVPKGISQSIG-------------GFVFQIRLLSTWGDEFYIGLNGIELYNRKGELMKIREHNLAAFPESVNILPN 470
Cdd:pfam14652 161 KQSESQLRSSSKCSSqasqdyetplmpcGFIFKFQLLSTWGDPYYIGLNGLELYDENGELIPLTENNIAAFPDSVNVLDG 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1767231573 471 IKNDLRTSNNLITQPNDTDIARNMWLTALLPNRCARVFFVFDVQTYISKIVIYNYRKTPERGVRHISVTVDDLIIFSG 548
Cdd:pfam14652 241 VSGDVRTPDKLIDGVNNTNDGRHMWLAPILPGLVNRIYVIFDQPITVSMIKIWNYSKTPSRGVKEFAILVDDLLIYNG 318
DUF4457 super family cl20613
Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is ...
 19-166 2.17e-14

Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.


The actual alignment was detected with superfamily member pfam14652:

Pssm-ID: 464238  Cd Length: 323  Bit Score: 74.23  E-value: 2.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231573  19 EPAEDEVNEEDQNEITIPELPEGRVLELRLLSNWGDSHYIGLNSVEIFTSTGERavIDKVTTNVTEYTGSLESLIVQRVH 98
Cdd:pfam14652 167 LRSSSKCSSQASQDYETPLMPCGFIFKFQLLSTWGDPYYIGLNGLELYDENGEL--IPLTENNIAAFPDSVNVLDGVSGD 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231573  99 CKDAEK-------------MWCAKTTE---EKIVLTLELKETckLALIRFWNYnaSRVHAQiGVRYLEMYLDGVGIFRGE 162
Cdd:pfam14652 245 VRTPDKlidgvnntndgrhMWLAPILPglvNRIYVIFDQPIT--VSMIKIWNY--SKTPSR-GVKEFAILVDDLLIYNGI 319


                  ....
gi 1767231573 163 LECA 166
Cdd:pfam14652 320 LRKA 323
 
Name Accession Description Interval E-value
DUF4457 pfam14652
Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is ...
 263-548 2.47e-88

Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.


Pssm-ID: 464238  Cd Length: 323  Bit Score: 275.69  E-value: 2.47e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231573 263 IELLSNWGMDGLIGLTGLELVDEHSQLI--DESQYTVTTSDGNS------DLSK--KLFNGRNLTRDPHDMWLVDFDSKN 332
Cdd:pfam14652   1 LNFLSTWGDRHYLGLTGLEVLGEDGKAIpiQLSNITASPRDLNDlpgysgDYRTldKLIDGTNVTTDDEHMWLIPFSPGK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231573 333 FTTISITFHDNVALKAISVWNYNASFELSYAGVKAAKIYINGKLIKNV---LLRKATGFVYFDYVQDVVLD------PNN 403
Cdd:pfam14652  81 EHTLTIDFGKPTSISGLRIWNYNKSLEDTYRGAKKVSVSLDGVVISPPegfLLRKAPGNCHFDFAQTISFPnvdkvnPPS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231573 404 TERDFVPKGISQSIG-------------GFVFQIRLLSTWGDEFYIGLNGIELYNRKGELMKIREHNLAAFPESVNILPN 470
Cdd:pfam14652 161 KQSESQLRSSSKCSSqasqdyetplmpcGFIFKFQLLSTWGDPYYIGLNGLELYDENGELIPLTENNIAAFPDSVNVLDG 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1767231573 471 IKNDLRTSNNLITQPNDTDIARNMWLTALLPNRCARVFFVFDVQTYISKIVIYNYRKTPERGVRHISVTVDDLIIFSG 548
Cdd:pfam14652 241 VSGDVRTPDKLIDGVNNTNDGRHMWLAPILPGLVNRIYVIFDQPITVSMIKIWNYSKTPSRGVKEFAILVDDLLIYNG 318
DUF4457 pfam14652
Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is ...
 19-166 2.17e-14

Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.


Pssm-ID: 464238  Cd Length: 323  Bit Score: 74.23  E-value: 2.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231573  19 EPAEDEVNEEDQNEITIPELPEGRVLELRLLSNWGDSHYIGLNSVEIFTSTGERavIDKVTTNVTEYTGSLESLIVQRVH 98
Cdd:pfam14652 167 LRSSSKCSSQASQDYETPLMPCGFIFKFQLLSTWGDPYYIGLNGLELYDENGEL--IPLTENNIAAFPDSVNVLDGVSGD 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231573  99 CKDAEK-------------MWCAKTTE---EKIVLTLELKETckLALIRFWNYnaSRVHAQiGVRYLEMYLDGVGIFRGE 162
Cdd:pfam14652 245 VRTPDKlidgvnntndgrhMWLAPILPglvNRIYVIFDQPIT--VSMIKIWNY--SKTPSR-GVKEFAILVDDLLIYNGI 319


                  ....
gi 1767231573 163 LECA 166
Cdd:pfam14652 320 LRKA 323
 
Name Accession Description Interval E-value
DUF4457 pfam14652
Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is ...
 263-548 2.47e-88

Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.


Pssm-ID: 464238  Cd Length: 323  Bit Score: 275.69  E-value: 2.47e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231573 263 IELLSNWGMDGLIGLTGLELVDEHSQLI--DESQYTVTTSDGNS------DLSK--KLFNGRNLTRDPHDMWLVDFDSKN 332
Cdd:pfam14652   1 LNFLSTWGDRHYLGLTGLEVLGEDGKAIpiQLSNITASPRDLNDlpgysgDYRTldKLIDGTNVTTDDEHMWLIPFSPGK 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231573 333 FTTISITFHDNVALKAISVWNYNASFELSYAGVKAAKIYINGKLIKNV---LLRKATGFVYFDYVQDVVLD------PNN 403
Cdd:pfam14652  81 EHTLTIDFGKPTSISGLRIWNYNKSLEDTYRGAKKVSVSLDGVVISPPegfLLRKAPGNCHFDFAQTISFPnvdkvnPPS 160

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231573 404 TERDFVPKGISQSIG-------------GFVFQIRLLSTWGDEFYIGLNGIELYNRKGELMKIREHNLAAFPESVNILPN 470
Cdd:pfam14652 161 KQSESQLRSSSKCSSqasqdyetplmpcGFIFKFQLLSTWGDPYYIGLNGLELYDENGELIPLTENNIAAFPDSVNVLDG 240

                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1767231573 471 IKNDLRTSNNLITQPNDTDIARNMWLTALLPNRCARVFFVFDVQTYISKIVIYNYRKTPERGVRHISVTVDDLIIFSG 548
Cdd:pfam14652 241 VSGDVRTPDKLIDGVNNTNDGRHMWLAPILPGLVNRIYVIFDQPITVSMIKIWNYSKTPSRGVKEFAILVDDLLIYNG 318
DUF4457 pfam14652
Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is ...
 19-166 2.17e-14

Domain of unknown function (DUF4457); This family of proteins is found in eukaryotes. It is found repeated several times in the vertebrate KIAA0556 proteins.


Pssm-ID: 464238  Cd Length: 323  Bit Score: 74.23  E-value: 2.17e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231573  19 EPAEDEVNEEDQNEITIPELPEGRVLELRLLSNWGDSHYIGLNSVEIFTSTGERavIDKVTTNVTEYTGSLESLIVQRVH 98
Cdd:pfam14652 167 LRSSSKCSSQASQDYETPLMPCGFIFKFQLLSTWGDPYYIGLNGLELYDENGEL--IPLTENNIAAFPDSVNVLDGVSGD 244

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767231573  99 CKDAEK-------------MWCAKTTE---EKIVLTLELKETckLALIRFWNYnaSRVHAQiGVRYLEMYLDGVGIFRGE 162
Cdd:pfam14652 245 VRTPDKlidgvnntndgrhMWLAPILPglvNRIYVIFDQPIT--VSMIKIWNY--SKTPSR-GVKEFAILVDDLLIYNGI 319


                  ....
gi 1767231573 163 LECA 166
Cdd:pfam14652 320 LRKA 323
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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