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Conserved domains on  [gi|1767287986|ref|NP_001362145|]
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SET domain-containing protein [Caenorhabditis elegans]

Protein Classification

SET domain-containing protein( domain architecture ID 10645844)

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain-containing protein may function as a protein-lysine N-methyltransferase, catalyzing the S-adenosyl-L-methionine (SAM)-dependent methylation at specific lysine residues of target proteins such as histones

CATH:  2.170.270.10
EC:  2.1.1.-
Gene Ontology:  GO:0005515|GO:0008168|GO:1904047
PubMed:  12372294|17013555|16086857

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 307-453 6.12e-10

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


:

Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 56.96  E-value: 6.12e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767287986  307 EKDFCVRAKQYFGQGEAVVEMTGEYVVSSSISDEDtyaldvvydtdkyqlaAIIDTNKKQKSVkkyppfvnkkytssILE 386
Cdd:smart00317  10 GKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERP----------------KAYDTDGAKAFY--------------LFD 59

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1767287986  387 LHEtPLSLNPRYVGNVGRFVSSSCMGNVKLNFVhtagFNPGNIRVIFTSTMPIFPSQEVTFRYSDEY 453
Cdd:smart00317  60 IDS-DLCIDARRKGNLARFINHSCEPNCELLFV----EVNGDDRIVIFALRDIKPGEELTIDYGSDY 121
 
Name Accession Description Interval E-value
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 307-453 6.12e-10

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 56.96  E-value: 6.12e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767287986  307 EKDFCVRAKQYFGQGEAVVEMTGEYVVSSSISDEDtyaldvvydtdkyqlaAIIDTNKKQKSVkkyppfvnkkytssILE 386
Cdd:smart00317  10 GKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERP----------------KAYDTDGAKAFY--------------LFD 59

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1767287986  387 LHEtPLSLNPRYVGNVGRFVSSSCMGNVKLNFVhtagFNPGNIRVIFTSTMPIFPSQEVTFRYSDEY 453
Cdd:smart00317  60 IDS-DLCIDARRKGNLARFINHSCEPNCELLFV----EVNGDDRIVIFALRDIKPGEELTIDYGSDY 121
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 225-469 8.11e-09

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 56.19  E-value: 8.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767287986 225 MQLRVNAEIEQEEelTCHCVDVC-GDLCPCSGLRKII---REGPLS------DPNRVrhYSCSTNCKCRGKC-------A 287
Cdd:cd10543    13 SPLNIDRNITSLQ--TCSCRDDCsSDNCVCGRLSVRCwydKEGRLLpdfnklDPPLI--FECNRACSCWRNCrnrvvqnG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767287986 288 ISFPeppkggteIMLHHLTEKDFCVRAKQYFGQGEAVVEMTGEyVVSSSISD---EDTYALDvvydtdkyqlaaiidtnk 364
Cdd:cd10543    89 IRYR--------LQLFRTRGMGWGVRALQDIPKGTFVCEYIGE-LISDSEADsreDDSYLFD------------------ 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767287986 365 kqksvkkyppfvnkkytssiLELHETPL-SLNPRYVGNVGRFVSSSCMGN---VKLnFVHTAGFN-PgniRVIFTSTMPI 439
Cdd:cd10543   142 --------------------LDNKDGETyCIDARRYGNISRFINHLCEPNlipVRV-FVEHQDLRfP---RIAFFASRDI 197

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1767287986 440 FPSQEVTFRYSDEY-IIKQLGDCCKCASLCC 469
Cdd:cd10543   198 KAGEELGFDYGEKFwRIKGKYFTCRCGSPKC 228
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 310-449 8.24e-05

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 42.13  E-value: 8.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767287986 310 FCVRAKQYFGQGEAVVEMTGEYVVSSSISDEDTYALDVVYDTDKYqlaaiidtnkkqksvKKYPPFVNKKYTSSIlelhe 389
Cdd:pfam00856   2 RGLFATEDIPKGEFIGEYVEVLLITKEEADKRELLYYDKLELRLW---------------GPYLFTLDEDSEYCI----- 61

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767287986 390 tplSLNPRYVGNVGRFVSSSCMGNVKLNFVhtagFNPGNIRVIFTSTMPIFPSQEVTFRY 449
Cdd:pfam00856  62 ---DARALYYGNWARFINHSCDPNCEVRVV----YVNGGPRIVIFALRDIKPGEELTIDY 114
 
Name Accession Description Interval E-value
SET smart00317
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on ...
 307-453 6.12e-10

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain; Putative methyl transferase, based on outlier plant homologues


Pssm-ID: 214614 [Multi-domain]  Cd Length: 124  Bit Score: 56.96  E-value: 6.12e-10
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767287986  307 EKDFCVRAKQYFGQGEAVVEMTGEYVVSSSISDEDtyaldvvydtdkyqlaAIIDTNKKQKSVkkyppfvnkkytssILE 386
Cdd:smart00317  10 GKGWGVRATEDIPKGEFIGEYVGEIITSEEAEERP----------------KAYDTDGAKAFY--------------LFD 59

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1767287986  387 LHEtPLSLNPRYVGNVGRFVSSSCMGNVKLNFVhtagFNPGNIRVIFTSTMPIFPSQEVTFRYSDEY 453
Cdd:smart00317  60 IDS-DLCIDARRKGNLARFINHSCEPNCELLFV----EVNGDDRIVIFALRDIKPGEELTIDYGSDY 121
SET_EHMT cd10543
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 225-469 8.11e-09

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase EHMT1, EHMT2 and similar proteins; This family includes EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380941 [Multi-domain]  Cd Length: 231  Bit Score: 56.19  E-value: 8.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767287986 225 MQLRVNAEIEQEEelTCHCVDVC-GDLCPCSGLRKII---REGPLS------DPNRVrhYSCSTNCKCRGKC-------A 287
Cdd:cd10543    13 SPLNIDRNITSLQ--TCSCRDDCsSDNCVCGRLSVRCwydKEGRLLpdfnklDPPLI--FECNRACSCWRNCrnrvvqnG 88

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767287986 288 ISFPeppkggteIMLHHLTEKDFCVRAKQYFGQGEAVVEMTGEyVVSSSISD---EDTYALDvvydtdkyqlaaiidtnk 364
Cdd:cd10543    89 IRYR--------LQLFRTRGMGWGVRALQDIPKGTFVCEYIGE-LISDSEADsreDDSYLFD------------------ 141

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767287986 365 kqksvkkyppfvnkkytssiLELHETPL-SLNPRYVGNVGRFVSSSCMGN---VKLnFVHTAGFN-PgniRVIFTSTMPI 439
Cdd:cd10543   142 --------------------LDNKDGETyCIDARRYGNISRFINHLCEPNlipVRV-FVEHQDLRfP---RIAFFASRDI 197

                         250       260       270
                  ....*....|....*....|....*....|.
gi 1767287986 440 FPSQEVTFRYSDEY-IIKQLGDCCKCASLCC 469
Cdd:cd10543   198 KAGEELGFDYGEKFwRIKGKYFTCRCGSPKC 228
SET_AtSUVH-like cd10545
SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar ...
 239-449 1.92e-06

SET domain found in Arabidopsis thaliana histone H3-K9 methyltransferases (SUVHs) and similar proteins; Arabidopsis thaliana SUVH protein (also termed suppressor of variegation 3-9 homolog protein) is a histone-lysine N-methyltransferase that methylates 'Lys-9' of histone H3. H3 'Lys-9' methylation represents a specific tag for epigenetic transcriptional repression. Some family members contain a post-SET domain which binds a Zn2+ ion. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380943 [Multi-domain]  Cd Length: 232  Bit Score: 48.94  E-value: 1.92e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767287986 239 LTCHCVDVCGDLCPCSGLRKIIREGPLSdpnrvrhYSCSTNCKCRGKCAISFPEppKGGT---EIMlhHLTEKDFCVRAK 315
Cdd:cd10545    35 SDCACVKKNGGEIPYNFNGRLIRAKPAI-------YECGPLCKCPPSCYNRVTQ--KGLRyrlEVF--KTAERGWGVRSW 103

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767287986 316 QYFGQGEAVVEMTGEyVVSSSISDEDTYALDVVYDTDKYQlaaiidTNKKQKSVKKYPPFVNKKYTSSILELHETPLSLN 395
Cdd:cd10545   104 DSIPAGSFICEYVGE-LLDTSEADTRSGNDDYLFDIDNRQ------TNRGWDGGQRLDVGMSDGERSSAEDEESSEFTID 176

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 1767287986 396 PRYVGNVGRFVSSSCMGNVKLNFV---HTAGFNPgniRVIFTSTMPIFPSQEVTFRY 449
Cdd:cd10545   177 AGSFGNVARFINHSCSPNLFVQCVlydHNDLRLP---RVMLFAADNIPPLQELTYDY 230
SET cd08161
SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, ...
 402-449 1.35e-05

SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily; The Su(var)3-9, Enhancer-of-zeste, Trithorax (SET) domain superfamily corresponds to SET domain-containing lysine methyltransferases, which catalyze site and state-specific methylation of lysine residues in histones that are fundamental in epigenetic regulation of gene activation and silencing in eukaryotic organisms. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains has been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as N-SET and C-SET. C-SET forms an unusual and conserved knot-like structure of probable functional importance. In addition to N-SET and C-SET, an insert region (I-SET) and flanking regions of high structural variability form part of the overall structure. Some family members contain a pre-SET domain, which is found in a number of histone methyltransferases (HMTase), and a post-SET domain, which harbors a zinc-binding site.


Pssm-ID: 380914 [Multi-domain]  Cd Length: 72  Bit Score: 43.01  E-value: 1.35e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 1767287986 402 VGRFVSSSCMGNVKLNFVHTAgfnpGNIRVIFTSTMPIFPSQEVTFRY 449
Cdd:cd08161    28 LARFINHSCEPNCEFEEVYVG----GKPRVFIVALRDIKAGEELTVDY 71
SET pfam00856
SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be ...
 310-449 8.24e-05

SET domain; SET domains are protein lysine methyltransferase enzymes. SET domains appear to be protein-protein interaction domains. It has been demonstrated that SET domains mediate interactions with a family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). A subset of SET domains have been called PR domains. These domains are divergent in sequence from other SET domains, but also appear to mediate protein-protein interaction. The SET domain consists of two regions known as SET-N and SET-C. SET-C forms an unusual and conserved knot-like structure of probably functional importance. Additionally to SET-N and SET-C, an insert region (SET-I) and flanking regions of high structural variability form part of the overall structure.


Pssm-ID: 459965 [Multi-domain]  Cd Length: 115  Bit Score: 42.13  E-value: 8.24e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767287986 310 FCVRAKQYFGQGEAVVEMTGEYVVSSSISDEDTYALDVVYDTDKYqlaaiidtnkkqksvKKYPPFVNKKYTSSIlelhe 389
Cdd:pfam00856   2 RGLFATEDIPKGEFIGEYVEVLLITKEEADKRELLYYDKLELRLW---------------GPYLFTLDEDSEYCI----- 61

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767287986 390 tplSLNPRYVGNVGRFVSSSCMGNVKLNFVhtagFNPGNIRVIFTSTMPIFPSQEVTFRY 449
Cdd:pfam00856  62 ---DARALYYGNWARFINHSCDPNCEVRVV----YVNGGPRIVIFALRDIKPGEELTIDY 114
SET_EHMT2 cd10533
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 241-469 9.56e-05

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 2 (EHMT2) and similar proteins; EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C (KMT1C), or protein G9a) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380931 [Multi-domain]  Cd Length: 239  Bit Score: 43.85  E-value: 9.56e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767287986 241 CHCVDVCGDL-CPCSGL---------RKIIREGPLSDPNRVrhYSCSTNCKCRGKCAISFPEppkGGTEIMLH-HLTEK- 308
Cdd:cd10533    27 CTCVDDCSSSnCLCGQLsircwydkdGRLLQEFNKIEPPLI--FECNQACSCWRNCKNRVVQ---SGIKVRLQlYRTAKm 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767287986 309 DFCVRAKQYFGQGEAVVEMTGEYvvsssISDEDTyalDVVYDtDKYqlaaIIDTNKKQKSVkkyppfvnkkytssilelh 388
Cdd:cd10533   102 GWGVRALQTIPQGTFICEYVGEL-----ISDAEA---DVRED-DSY----LFDLDNKDGEV------------------- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767287986 389 etpLSLNPRYVGNVGRFVSSSCMGN---VKLNFVHTAGFNPgniRVIFTSTMPIFPSQEVTFRYSDEYI-IKQLGDCCKC 464
Cdd:cd10533   150 ---YCIDARYYGNISRFINHLCDPNiipVRVFMLHQDLRFP---RIAFFSSRDIRTGEELGFDYGDRFWdIKSKYFTCQC 223


                  ....*
gi 1767287986 465 ASLCC 469
Cdd:cd10533   224 GSEKC 228
SET_SETDB-like cd10538
SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) ...
 312-450 1.22e-04

SET domain (including pre-SET and post-SET domains) found in SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2, and similar proteins; The family includes SET domain bifurcated 1 (SETDB1) and 2 (SETDB2), suppressor of variegation 3-9 homologs, SUV39H1 and SUV39H2, euchromatic histone-lysine N-methyltransferase EHMT1 and EHMT2. SETDB1 (EC 2.1.1.43; also termed ERG-associated protein with SET domain (ESET), histone H3-K9 methyltransferase 4, H3-K9-HMTase 4, or lysine N-methyltransferase 1E (KMT1E)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It mainly functions in euchromatin regions, thereby playing a central role in the silencing of euchromatic genes. SETDB2 (EC 2.1.1.43; also termed chronic lymphocytic leukemia deletion region gene 8 protein (CLLD8), or lysine N-methyltransferase 1F (KMT1F)) acts as a histone-lysine N-methyltransferase that specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). It is involved in left-right axis specification in early development and mitosis. SUV39H1 (also termed histone H3-K9 methyltransferase 1, H3-K9-HMTase 1, lysine N-methyltransferase 1A, KMT1A, position-effect variegation 3-9 homolog, SUV39H, or Su(var)3-9 homolog 1) and SUV39H2 (also termed histone H3-K9 methyltransferase 2, H3-K9-HMTase 2, lysine N-methyltransferase 1B, KMT1B, or Su(var)3-9 homolog 2), both act as histone-lysine N-methyltransferases that specifically trimethylate 'Lys-9' of histone H3 (H3K9me3) using monomethylated H3 'Lys-9' as substrate. They mainly function in heterochromatin regions, thereby playing central roles in the establishment of constitutive heterochromatin at pericentric and telomere regions. EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, lysine N-methyltransferase 1D, or KMT1D) and EHMT2 (also termed Eu-HMTase2, HLA-B-associated transcript 8, histone H3-K9 methyltransferase 3, H3-K9-HMTase 3, lysine N-methyltransferase 1C, KMT1C, or protein G9a), both act as histone-lysine N-methyltransferases that specifically mono- and dimethylate 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin. This family also includes the pre-SET domain, which is found in a number of histone methyltransferases (HMTase), N-terminal to the SET domain. Pre-SET domain is a zinc binding motif which contains 9 conserved cysteines that coordinate three zinc ions. It is thought that this region plays a structural role in stabilizing SET domains. Most family members, except for Arabidopsis thaliana SUVH9, contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380936 [Multi-domain]  Cd Length: 217  Bit Score: 43.51  E-value: 1.22e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767287986 312 VRAKQYFGQGEAVVEMTGEYvvsssISDEDTYALDVVYDT--DKYqlaaIIDTNKKQKSvkkyppfvnkkytssilELHE 389
Cdd:cd10538   103 VRSLEFIPKGSFVCEYVGEV-----ITTSEADRRGKIYDKsgGSY----LFDLDEFSDS-----------------DGDG 156

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1767287986 390 TPLSLNPRYVGNVGRFVSSSCMGNVKLNFVHTAGFNPGNIRVIFTSTMPIFPSQEVTFRYS 450
Cdd:cd10538   157 EELCVDATFCGNVSRFINHSCDPNLFPFNVVIDHDDLRYPRIALFATRDILPGEELTFDYG 217
SET_EHMT1 cd10535
SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine ...
 241-469 1.98e-04

SET domain (including pre-SET and post-SET domains) found in euchromatic histone-lysine N-methyltransferase 1 (EHMT1) and similar proteins; EHMT1 (also termed Eu-HMTase1, G9a-like protein 1, GLP, GLP1, histone H3-K9 methyltransferase 5, H3-K9-HMTase 5, or lysine N-methyltransferase 1D (KMT1D)) acts as a histone-lysine N-methyltransferase that specifically mono- and dimethylates 'Lys-9' of histone H3 (H3K9me1 and H3K9me2, respectively) in euchromatin.


Pssm-ID: 380933 [Multi-domain]  Cd Length: 231  Bit Score: 43.00  E-value: 1.98e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767287986 241 CHCVDVCGDL-CPCSGLR---------KIIREGPLSDPNRVrhYSCSTNCKCRGKCAISFPEppkGG--TEIMLHHLTEK 308
Cdd:cd10535    27 CVCIDDCSSSnCMCGQLSmrcwydkdgRLLPEFNMAEPPLI--FECNHACSCWRNCRNRVVQ---NGlrARLQLYRTRDM 101

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767287986 309 DFCVRAKQYFGQGEAVVEMTGEYVVSSS--ISDEDTYaldvvydtdkyqlaaIIDTNKKQKSVkkyppfvnkkytssile 386
Cdd:cd10535   102 GWGVRSLQDIPPGTFVCEYVGELISDSEadVREEDSY---------------LFDLDNKDGEV----------------- 149

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767287986 387 lhetpLSLNPRYVGNVGRFVSSSCMGN---VKLNFVHTAGFNPgniRVIFTSTMPIFPSQEVTFRYSDEYI-IKQLGDCC 462
Cdd:cd10535   150 -----YCIDARFYGNVSRFINHHCEPNlvpVRVFMAHQDLRFP---RIAFFSTRLIEAGEQLGFDYGERFWdIKGKLFSC 221


                  ....*..
gi 1767287986 463 KCASLCC 469
Cdd:cd10535   222 RCGSPKC 228
SET_SETD5-like cd10529
SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine ...
 303-453 8.26e-04

SET domain found in SET domain-containing protein 5 (SETD5), inactive histone-lysine N-methyltransferase 2E (KMT2E) and similar proteins; SETD5 is a probable transcriptional regulator that acts via the formation of large multiprotein complexes that modify and/or remodel the chromatin. KMT2E (also termed inactive lysine N-methyltransferase 2E or myeloid/lymphoid or mixed-lineage leukemia protein 5 (MLL5)) associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. The family also includes Saccharomyces cerevisiae SET domain-containing proteins, SET3 and SET4, and Schizosaccharomyces pombe SET3. Most of these family members contain a post-SET domain which harbors a zinc-binding site.


Pssm-ID: 380927  Cd Length: 127  Bit Score: 39.57  E-value: 8.26e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767287986 303 HHLTEKDFC-VRAKQYFG--------QGEAVVEMTGEYVVSSSISDEdtyaldvvydtdkyqlaaiidtnkkQKSVKKYP 373
Cdd:cd10529     1 RKLTSRTVEkVVGKNRKGlvatedisPGEPILEYKGEVSLRSEFKED-------------------------NGFFKRPS 55

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767287986 374 PFVNKKYTssileLHETPLSLNPRYVGNVGRFVSSSCMGNVKLnfVHTAGFNpGNIRVIFTSTMPIFPSQEVTFRYSDEY 453
Cdd:cd10529    56 PFVFFYDG-----FEGLPLCVDARKYGNEARFIRRSCRPNAEL--RHVVVSN-GELRLFIFALKDIRKGTEITIPFDYDY 127
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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