NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1767344668|ref|NP_001362209|]
View 

complement factor I isoform 6 preproprotein [Homo sapiens]

Protein Classification

LDL receptor domain-containing protein; serine protease( domain architecture ID 11249539)

Low Density Lipoprotein (LDL) receptor class A domain is a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism| trypsin-like serine protease catalyzes the cleavage of specific peptide bonds in protein substrates using an active site serine as the nucleophile; contains C-terminal DNA polymerase III subunits gamma and tau

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 333-504 7.78e-43

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


:

Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 153.20  E-value: 7.78e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767344668 333 IVGGKRAQLGDLPWQVAIKDASG-ITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDLKRIVIEyVDRIIFH 411
Cdd:cd00190     1 IVGGSEAKIGSFPWQVSLQYTGGrHFCGGSLISPRWVLTAAHCVYSSAPSNYTVRLGSHDLSSNEGGGQVIK-VKKVIVH 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767344668 412 ENYNAGTYQNDIALIEMKKDGNKKDcelpRSIPACVPWSPYLFQPNDTCIVSGWGREKDNERV-FSLQWGEVKLISN--C 488
Cdd:cd00190    80 PNYNPSTYDNDIALLKLKRPVTLSD----NVRPICLPSSGYNLPAGTTCTVSGWGRTSEGGPLpDVLQEVNVPIVSNaeC 155

                         170
                  ....*....|....*..
gi 1767344668 489 SKFYGNRFY-EKEMECA 504
Cdd:cd00190   156 KRAYSYGGTiTDNMLCA 172
FIMAC smart00057
factor I membrane attack complex;
43-108 7.66e-27

factor I membrane attack complex;


:

Pssm-ID: 214493 [Multi-domain]  Cd Length: 68  Bit Score: 103.39  E-value: 7.66e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1767344668   43 CDKVFCQPWQRCIEGTCVCKLPYQCPKNGTAVCATNRRS--FPTYCQQKSLECLHPGTKFLNNGTCTA 108
Cdd:smart00057   1 CAKGFCQLWQKCSASTCVCKLPYECPKAGTDVCVEDGRSekTLTYCKQGALRCLNQKYKFLHIGSCTA 68
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 114-215 3.06e-19

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


:

Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 82.77  E-value: 3.06e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767344668  114 VSLKHGNTDSEGIVEVKLvdQDKTMFICKSSWSMREANVACLDLGFQQGADTQRRFKLSDLSiNSTECLHVHCRGLETSL 193
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYH--NGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGS-GPIWLDNVRCSGTEASL 77

                           90       100
                   ....*....|....*....|....
gi 1767344668  194 AECTFT--KRRTMGYQDFADVVCY 215
Cdd:smart00202  78 SDCPHSgwGSHNCSHGEDAGVVCS 101
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
257-293 5.28e-10

Low-density lipoprotein receptor domain class A;


:

Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.56  E-value: 5.28e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1767344668 257 KACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGC 293
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 224-256 6.51e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


:

Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.05  E-value: 6.51e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1767344668 224 DDFFQCVNGKYISQMKACDGINDCGDQSDELCC 256
Cdd:cd00112     3 PNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
 
Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 333-504 7.78e-43

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 153.20  E-value: 7.78e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767344668 333 IVGGKRAQLGDLPWQVAIKDASG-ITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDLKRIVIEyVDRIIFH 411
Cdd:cd00190     1 IVGGSEAKIGSFPWQVSLQYTGGrHFCGGSLISPRWVLTAAHCVYSSAPSNYTVRLGSHDLSSNEGGGQVIK-VKKVIVH 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767344668 412 ENYNAGTYQNDIALIEMKKDGNKKDcelpRSIPACVPWSPYLFQPNDTCIVSGWGREKDNERV-FSLQWGEVKLISN--C 488
Cdd:cd00190    80 PNYNPSTYDNDIALLKLKRPVTLSD----NVRPICLPSSGYNLPAGTTCTVSGWGRTSEGGPLpDVLQEVNVPIVSNaeC 155

                         170
                  ....*....|....*..
gi 1767344668 489 SKFYGNRFY-EKEMECA 504
Cdd:cd00190   156 KRAYSYGGTiTDNMLCA 172
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 332-504 7.82e-43

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 153.22  E-value: 7.82e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767344668  332 RIVGGKRAQLGDLPWQVAIKDASG-ITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDLKRIVieYVDRIIF 410
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLQYGGGrHFCGGSLISPRWVLTAAHCVRGSDPSNIRVRLGSHDLSSGEEGQVI--KVSKVII 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767344668  411 HENYNAGTYQNDIALIEMKKDGNkkdceLPRSI-PACVPWSPYLFQPNDTCIVSGWGREKDNERVFS--LQWGEVKLISN 487
Cdd:smart00020  79 HPNYNPSTYDNDIALLKLKEPVT-----LSDNVrPICLPSSNYNVPAGTTCTVSGWGRTSEGAGSLPdtLQEVNVPIVSN 153

                          170       180
                   ....*....|....*....|
gi 1767344668  488 --CSKFYGNRFYEKE-MECA 504
Cdd:smart00020 154 atCRRAYSGGGAITDnMLCA 173
Trypsin pfam00089
Trypsin;
333-505 1.34e-39

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 144.12  E-value: 1.34e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767344668 333 IVGGKRAQLGDLPWQVAIKDASG-ITCGGIYIGGCWILTAAHCLRASktHRYQIWTTVvDWIHPDLKRIVIEYVDRIIFH 411
Cdd:pfam00089   1 IVGGDEAQPGSFPWQVSLQLSSGkHFCGGSLISENWVLTAAHCVSGA--SDVKVVLGA-HNIVLREGGEQKFDVEKIIVH 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767344668 412 ENYNAGTYQNDIALIEMKKDGNKKDCELPRSIPAcvpwSPYLFQPNDTCIVSGWGREKDNERVFSLQWGEVKLISN--CS 489
Cdd:pfam00089  78 PNYNPDTLDNDIALLKLESPVTLGDTVRPICLPD----ASSDLPVGTTCTVSGWGNTKTLGPSDTLQEVTVPVVSRetCR 153

                         170
                  ....*....|....*.
gi 1767344668 490 KFYGNRFYEkEMECAD 505
Cdd:pfam00089 154 SAYGGTVTD-TMICAG 168
FIMAC smart00057
factor I membrane attack complex;
43-108 7.66e-27

factor I membrane attack complex;


Pssm-ID: 214493 [Multi-domain]  Cd Length: 68  Bit Score: 103.39  E-value: 7.66e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1767344668   43 CDKVFCQPWQRCIEGTCVCKLPYQCPKNGTAVCATNRRS--FPTYCQQKSLECLHPGTKFLNNGTCTA 108
Cdd:smart00057   1 CAKGFCQLWQKCSASTCVCKLPYECPKAGTDVCVEDGRSekTLTYCKQGALRCLNQKYKFLHIGSCTA 68
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 332-505 4.99e-26

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 107.43  E-value: 4.99e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767344668 332 RIVGGKRAQLGDLPWQVAIKDASGI---TCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDLKRIVieyVDRI 408
Cdd:COG5640    30 AIVGGTPATVGEYPWMVALQSSNGPsgqFCGGTLIAPRWVLTAAHCVDGDGPSDLRVVIGSTDLSTSGGTVVK---VARI 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767344668 409 IFHENYNAGTYQNDIALIEMKKDgnkkdceLPRSIPACVPWSPYLFQPNDTCIVSGWGREKDNERVFS--LQWGEVKLIS 486
Cdd:COG5640   107 VVHPDYDPATPGNDIALLKLATP-------VPGVAPAPLATSADAAAPGTPATVAGWGRTSEGPGSQSgtLRKADVPVVS 179

                         170
                  ....*....|....*....
gi 1767344668 487 NCSKFYGNRFYEKEMECAD 505
Cdd:COG5640   180 DATCAAYGGFDGGTMLCAG 198
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 114-215 3.06e-19

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 82.77  E-value: 3.06e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767344668  114 VSLKHGNTDSEGIVEVKLvdQDKTMFICKSSWSMREANVACLDLGFQQGADTQRRFKLSDLSiNSTECLHVHCRGLETSL 193
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYH--NGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGS-GPIWLDNVRCSGTEASL 77

                           90       100
                   ....*....|....*....|....
gi 1767344668  194 AECTFT--KRRTMGYQDFADVVCY 215
Cdd:smart00202  78 SDCPHSgwGSHNCSHGEDAGVVCS 101
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
257-293 5.28e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.56  E-value: 5.28e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1767344668 257 KACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGC 293
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
SRCR pfam00530
Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...
 119-214 4.45e-08

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.


Pssm-ID: 459844  Cd Length: 98  Bit Score: 51.22  E-value: 4.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767344668 119 GNTDSEGIVEVKLVDQDKTmfICKSSWSMREANVACLDLGFQQGADTQRRFKLSDLSINSTECLH-VHCRGLETSLAECT 197
Cdd:pfam00530   1 GSSPCEGRVEVYHNGSWGT--VCDDGWDLRDAHVVCRQLGCGGAVSAPSGCSYFGPGSTGPIWLDdVRCSGNETSLWQCP 78

                          90
                  ....*....|....*....
gi 1767344668 198 F--TKRRTMGYQDFADVVC 214
Cdd:pfam00530  79 HrpWGNHNCSHSEDAGVIC 97
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 259-293 1.93e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.20  E-value: 1.93e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1767344668 259 CQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGC 293
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 224-256 6.51e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.05  E-value: 6.51e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1767344668 224 DDFFQCVNGKYISQMKACDGINDCGDQSDELCC 256
Cdd:cd00112     3 PNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 225-253 1.44e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.93  E-value: 1.44e-06
                           10        20
                   ....*....|....*....|....*....
gi 1767344668  225 DFFQCVNGKYISQMKACDGINDCGDQSDE 253
Cdd:smart00192   5 GEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 259-290 4.20e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.39  E-value: 4.20e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1767344668  259 CQGKGFHCKSGVCIPSQYQCNGEVDCITGEDE 290
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
227-256 1.61e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 41.85  E-value: 1.61e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1767344668 227 FQCVNGKYISQMKACDGINDCGDQSDELCC 256
Cdd:pfam00057   8 FQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
 
Name Accession Description Interval E-value
Tryp_SPc cd00190
Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens ...
 333-504 7.78e-43

Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad residues.


Pssm-ID: 238113 [Multi-domain]  Cd Length: 232  Bit Score: 153.20  E-value: 7.78e-43
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767344668 333 IVGGKRAQLGDLPWQVAIKDASG-ITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDLKRIVIEyVDRIIFH 411
Cdd:cd00190     1 IVGGSEAKIGSFPWQVSLQYTGGrHFCGGSLISPRWVLTAAHCVYSSAPSNYTVRLGSHDLSSNEGGGQVIK-VKKVIVH 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767344668 412 ENYNAGTYQNDIALIEMKKDGNKKDcelpRSIPACVPWSPYLFQPNDTCIVSGWGREKDNERV-FSLQWGEVKLISN--C 488
Cdd:cd00190    80 PNYNPSTYDNDIALLKLKRPVTLSD----NVRPICLPSSGYNLPAGTTCTVSGWGRTSEGGPLpDVLQEVNVPIVSNaeC 155

                         170
                  ....*....|....*..
gi 1767344668 489 SKFYGNRFY-EKEMECA 504
Cdd:cd00190   156 KRAYSYGGTiTDNMLCA 172
Tryp_SPc smart00020
Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens ...
 332-504 7.82e-43

Trypsin-like serine protease; Many of these are synthesised as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. A few, however, are active as single chain molecules, and others are inactive due to substitutions of the catalytic triad residues.


Pssm-ID: 214473  Cd Length: 229  Bit Score: 153.22  E-value: 7.82e-43
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767344668  332 RIVGGKRAQLGDLPWQVAIKDASG-ITCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDLKRIVieYVDRIIF 410
Cdd:smart00020   1 RIVGGSEANIGSFPWQVSLQYGGGrHFCGGSLISPRWVLTAAHCVRGSDPSNIRVRLGSHDLSSGEEGQVI--KVSKVII 78

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767344668  411 HENYNAGTYQNDIALIEMKKDGNkkdceLPRSI-PACVPWSPYLFQPNDTCIVSGWGREKDNERVFS--LQWGEVKLISN 487
Cdd:smart00020  79 HPNYNPSTYDNDIALLKLKEPVT-----LSDNVrPICLPSSNYNVPAGTTCTVSGWGRTSEGAGSLPdtLQEVNVPIVSN 153

                          170       180
                   ....*....|....*....|
gi 1767344668  488 --CSKFYGNRFYEKE-MECA 504
Cdd:smart00020 154 atCRRAYSGGGAITDnMLCA 173
Trypsin pfam00089
Trypsin;
333-505 1.34e-39

Trypsin;


Pssm-ID: 459667 [Multi-domain]  Cd Length: 219  Bit Score: 144.12  E-value: 1.34e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767344668 333 IVGGKRAQLGDLPWQVAIKDASG-ITCGGIYIGGCWILTAAHCLRASktHRYQIWTTVvDWIHPDLKRIVIEYVDRIIFH 411
Cdd:pfam00089   1 IVGGDEAQPGSFPWQVSLQLSSGkHFCGGSLISENWVLTAAHCVSGA--SDVKVVLGA-HNIVLREGGEQKFDVEKIIVH 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767344668 412 ENYNAGTYQNDIALIEMKKDGNKKDCELPRSIPAcvpwSPYLFQPNDTCIVSGWGREKDNERVFSLQWGEVKLISN--CS 489
Cdd:pfam00089  78 PNYNPDTLDNDIALLKLESPVTLGDTVRPICLPD----ASSDLPVGTTCTVSGWGNTKTLGPSDTLQEVTVPVVSRetCR 153

                         170
                  ....*....|....*.
gi 1767344668 490 KFYGNRFYEkEMECAD 505
Cdd:pfam00089 154 SAYGGTVTD-TMICAG 168
FIMAC smart00057
factor I membrane attack complex;
43-108 7.66e-27

factor I membrane attack complex;


Pssm-ID: 214493 [Multi-domain]  Cd Length: 68  Bit Score: 103.39  E-value: 7.66e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1767344668   43 CDKVFCQPWQRCIEGTCVCKLPYQCPKNGTAVCATNRRS--FPTYCQQKSLECLHPGTKFLNNGTCTA 108
Cdd:smart00057   1 CAKGFCQLWQKCSASTCVCKLPYECPKAGTDVCVEDGRSekTLTYCKQGALRCLNQKYKFLHIGSCTA 68
COG5640 COG5640
Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, ...
 332-505 4.99e-26

Secreted trypsin-like serine protease [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 444365 [Multi-domain]  Cd Length: 262  Bit Score: 107.43  E-value: 4.99e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767344668 332 RIVGGKRAQLGDLPWQVAIKDASGI---TCGGIYIGGCWILTAAHCLRASKTHRYQIWTTVVDWIHPDLKRIVieyVDRI 408
Cdd:COG5640    30 AIVGGTPATVGEYPWMVALQSSNGPsgqFCGGTLIAPRWVLTAAHCVDGDGPSDLRVVIGSTDLSTSGGTVVK---VARI 106

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767344668 409 IFHENYNAGTYQNDIALIEMKKDgnkkdceLPRSIPACVPWSPYLFQPNDTCIVSGWGREKDNERVFS--LQWGEVKLIS 486
Cdd:COG5640   107 VVHPDYDPATPGNDIALLKLATP-------VPGVAPAPLATSADAAAPGTPATVAGWGRTSEGPGSQSgtLRKADVPVVS 179

                         170
                  ....*....|....*....
gi 1767344668 487 NCSKFYGNRFYEKEMECAD 505
Cdd:COG5640   180 DATCAAYGGFDGGTMLCAG 198
SR smart00202
Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR ...
 114-215 3.06e-19

Scavenger receptor Cys-rich; The sea urchin egg peptide speract contains 4 repeats of SR domains that contain 6 conserved cysteines. May bind bacterial antigens in the protein MARCO.


Pssm-ID: 214555 [Multi-domain]  Cd Length: 101  Bit Score: 82.77  E-value: 3.06e-19
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767344668  114 VSLKHGNTDSEGIVEVKLvdQDKTMFICKSSWSMREANVACLDLGFQQGADTQRRFKLSDLSiNSTECLHVHCRGLETSL 193
Cdd:smart00202   1 VRLVGGGSPCEGRVEVYH--NGQWGTVCDDGWDLRDANVVCRQLGFGGAVSASGSAYFGPGS-GPIWLDNVRCSGTEASL 77

                           90       100
                   ....*....|....*....|....
gi 1767344668  194 AECTFT--KRRTMGYQDFADVVCY 215
Cdd:smart00202  78 SDCPHSgwGSHNCSHGEDAGVVCS 101
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
257-293 5.28e-10

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 54.56  E-value: 5.28e-10
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 1767344668 257 KACQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGC 293
Cdd:pfam00057   1 STCSPNEFQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
SRCR pfam00530
Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular ...
 119-214 4.45e-08

Scavenger receptor cysteine-rich domain; These domains are disulphide rich extracellular domains. These domains are found in several extracellular receptors and may be involved in protein-protein interactions.


Pssm-ID: 459844  Cd Length: 98  Bit Score: 51.22  E-value: 4.45e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1767344668 119 GNTDSEGIVEVKLVDQDKTmfICKSSWSMREANVACLDLGFQQGADTQRRFKLSDLSINSTECLH-VHCRGLETSLAECT 197
Cdd:pfam00530   1 GSSPCEGRVEVYHNGSWGT--VCDDGWDLRDAHVVCRQLGCGGAVSAPSGCSYFGPGSTGPIWLDdVRCSGNETSLWQCP 78

                          90
                  ....*....|....*....
gi 1767344668 198 F--TKRRTMGYQDFADVVC 214
Cdd:pfam00530  79 HrpWGNHNCSHSEDAGVIC 97
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 259-293 1.93e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 47.20  E-value: 1.93e-07
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 1767344668 259 CQGKGFHCKSGVCIPSQYQCNGEVDCITGEDEVGC 293
Cdd:cd00112     1 CPPNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa cd00112
Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central ...
 224-256 6.51e-07

Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about 40 amino acids are present in the N-terminal of this multidomain membrane protein; other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement; the binding of calcium is required for in vitro formation of the native disulfide isomer and is necessary in establishing and maintaining the modular structure


Pssm-ID: 238060  Cd Length: 35  Bit Score: 46.05  E-value: 6.51e-07
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1767344668 224 DDFFQCVNGKYISQMKACDGINDCGDQSDELCC 256
Cdd:cd00112     3 PNEFRCANGRCIPSSWVCDGEDDCGDGSDEENC 35
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 225-253 1.44e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 44.93  E-value: 1.44e-06
                           10        20
                   ....*....|....*....|....*....
gi 1767344668  225 DFFQCVNGKYISQMKACDGINDCGDQSDE 253
Cdd:smart00192   5 GEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
LDLa smart00192
Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density ...
 259-290 4.20e-06

Low-density lipoprotein receptor domain class A; Cysteine-rich repeat in the low-density lipoprotein (LDL) receptor that plays a central role in mammalian cholesterol metabolism. The N-terminal type A repeats in LDL receptor bind the lipoproteins. Other homologous domains occur in related receptors, including the very low-density lipoprotein receptor and the LDL receptor-related protein/alpha 2-macroglobulin receptor, and in proteins which are functionally unrelated, such as the C9 component of complement. Mutations in the LDL receptor gene cause familial hypercholesterolemia.


Pssm-ID: 197566  Cd Length: 33  Bit Score: 43.39  E-value: 4.20e-06
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1767344668  259 CQGKGFHCKSGVCIPSQYQCNGEVDCITGEDE 290
Cdd:smart00192   2 CPPGEFQCDNGRCIPSSWVCDGVDDCGDGSDE 33
Ldl_recept_a pfam00057
Low-density lipoprotein receptor domain class A;
227-256 1.61e-05

Low-density lipoprotein receptor domain class A;


Pssm-ID: 395011  Cd Length: 37  Bit Score: 41.85  E-value: 1.61e-05
                          10        20        30
                  ....*....|....*....|....*....|
gi 1767344668 227 FQCVNGKYISQMKACDGINDCGDQSDELCC 256
Cdd:pfam00057   8 FQCGSGECIPRSWVCDGDPDCGDGSDEENC 37
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH