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Conserved domains on  [gi|1775986642|ref|NP_001363435|]
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DENN domain-containing protein 2B isoform 8 [Homo sapiens]

Protein Classification

DENN domain-containing protein( domain architecture ID 10655294)

DENN domain-containing protein may be involved in Rab-mediated processes or regulation of mitogen-activated protein kinase (MAPK) signalling pathways

CATH:  3.30.450.200|3.40.50.11500
Gene Ontology:  GO:0005085|GO:0032483
PubMed:  21330364|11563850
SCOP:  4007417|4006687

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 263-447 5.88e-75

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


:

Pssm-ID: 460461  Cd Length: 186  Bit Score: 237.09  E-value: 5.88e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775986642 263 RLPEVYCVISRLGCFGLFSKVLDEVERRRGISA--ALVYPFMRS-LMESPFPAPGKTIKVKtflPGAGNEVLELRRPMDS 339
Cdd:pfam02141   1 RIPKAYCIISRLPFFNLFKKFLDELYRRRTISPlpNPIERFIANlLYEVPFPPPGRTQKLK---PLGGTEPILLQRPEDS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775986642 340 RL--EHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPT 417
Cdd:pfam02141  78 ELplEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPT 157

                         170       180       190
                  ....*....|....*....|....*....|
gi 1775986642 418 PFLVGLLSSSLPkLKELPVEEALMVNLGSD 447
Cdd:pfam02141 158 PFIIGVHSRYFD-LLEDPLDDVVLVDLDTG 186
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 169-256 1.77e-23

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 214824  Cd Length: 89  Bit Score: 94.71  E-value: 1.77e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775986642  169 FEYFVVVSLKKK--PSRNTYLPEVSYQFPKLDRptkqmrEAEERLKAIPQFCFPDAKDWLPVSEYS-SETFSFMLTGEDG 245
Cdd:smart00800   5 FDYFVVVGLDSDtgPLGRSYKPEILQRYPEKDF------EDFPLPDSIPLFCFPEGLDFVTQTSSKdPQFFSFVLTDIDG 78

                           90
                   ....*....|.
gi 1775986642  246 SRRFGYCRRLL 256
Cdd:smart00800  79 SRRYGFCLRFY 89
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 495-561 7.95e-16

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


:

Pssm-ID: 129037  Cd Length: 69  Bit Score: 72.32  E-value: 7.95e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775986642  495 NGLVSEVFIRFFVETVGHYSLFLTQSEK---GERAFQREAFRKSVASKSiRRFLEVFMESQMFAGFIQDR 561
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLRELRKepgPVITFDKESFLKSRPSSE-RPFLSKFLETQMFSQFIEER 69
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 263-447 5.88e-75

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 237.09  E-value: 5.88e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775986642 263 RLPEVYCVISRLGCFGLFSKVLDEVERRRGISA--ALVYPFMRS-LMESPFPAPGKTIKVKtflPGAGNEVLELRRPMDS 339
Cdd:pfam02141   1 RIPKAYCIISRLPFFNLFKKFLDELYRRRTISPlpNPIERFIANlLYEVPFPPPGRTQKLK---PLGGTEPILLQRPEDS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775986642 340 RL--EHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPT 417
Cdd:pfam02141  78 ELplEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPT 157

                         170       180       190
                  ....*....|....*....|....*....|
gi 1775986642 418 PFLVGLLSSSLPkLKELPVEEALMVNLGSD 447
Cdd:pfam02141 158 PFIIGVHSRYFD-LLEDPLDDVVLVDLDTG 186
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 264-447 3.90e-71

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 227.08  E-value: 3.90e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775986642  264 LPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGagnEVLELRRPMDSRLEH 343
Cdd:smart00799   1 APKCICILSRLPFFELFRKILNELYRLLPSSSNLPLELLISLLLYPVPPPGGSLVLVSLGPG---DLIELQRPLDSSLPL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775986642  344 VDFEC--LFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLV 421
Cdd:smart00799  78 IDFSLheLFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFII 157

                          170       180
                   ....*....|....*....|....*.
gi 1775986642  422 GLLSSSLPKLKELPVEEALMVNLGSD 447
Cdd:smart00799 158 GVHSSYFEEVKELPDEDVVVVDLDTG 183
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 169-256 1.77e-23

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 94.71  E-value: 1.77e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775986642  169 FEYFVVVSLKKK--PSRNTYLPEVSYQFPKLDRptkqmrEAEERLKAIPQFCFPDAKDWLPVSEYS-SETFSFMLTGEDG 245
Cdd:smart00800   5 FDYFVVVGLDSDtgPLGRSYKPEILQRYPEKDF------EDFPLPDSIPLFCFPEGLDFVTQTSSKdPQFFSFVLTDIDG 78

                           90
                   ....*....|.
gi 1775986642  246 SRRFGYCRRLL 256
Cdd:smart00800  79 SRRYGFCLRFY 89
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 495-561 7.95e-16

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 72.32  E-value: 7.95e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775986642  495 NGLVSEVFIRFFVETVGHYSLFLTQSEK---GERAFQREAFRKSVASKSiRRFLEVFMESQMFAGFIQDR 561
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLRELRKepgPVITFDKESFLKSRPSSE-RPFLSKFLETQMFSQFIEER 69
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 188-254 2.65e-14

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 67.63  E-value: 2.65e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1775986642 188 PEVSYQFPKLDRPTKQMreaeerLKAIPQFCFPDakDWLPVSEYSSETFSFMLTGEDGSRRFGYCRR 254
Cdd:pfam03456   1 PEVLDRYPEDDWSDPPL------PDGIPMFCFPE--GLETLSSREPTFFSFVLTDEDGSRLYGACLT 59
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 527-575 8.10e-11

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 57.20  E-value: 8.10e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1775986642 527 FQREAFRKSVASKSiRRFLEVFMESQMFAGFIQDRELRKCRAKGLFEQR 575
Cdd:pfam03455   1 FDKEAFLKSLPSDS-RPFLSQFLETQMFNEFIEERLESSDPSIDLFDEE 48
 
Name Accession Description Interval E-value
DENN pfam02141
DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a ...
 263-447 5.88e-75

DENN (AEX-3) domain; DENN (after differentially expressed in neoplastic vs normal cells) is a domain which occurs in several proteins involved in Rab- mediated processes or regulation of MAPK signalling pathways.


Pssm-ID: 460461  Cd Length: 186  Bit Score: 237.09  E-value: 5.88e-75
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775986642 263 RLPEVYCVISRLGCFGLFSKVLDEVERRRGISA--ALVYPFMRS-LMESPFPAPGKTIKVKtflPGAGNEVLELRRPMDS 339
Cdd:pfam02141   1 RIPKAYCIISRLPFFNLFKKFLDELYRRRTISPlpNPIERFIANlLYEVPFPPPGRTQKLK---PLGGTEPILLQRPEDS 77

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775986642 340 RL--EHVDFECLFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPT 417
Cdd:pfam02141  78 ELplEGVDLHLLFRCLSPENILQLFEAALLERRIIFLSSDLARLTLVAEAVVALLYPFVWQHIYIPVLPASLLDVLSAPT 157

                         170       180       190
                  ....*....|....*....|....*....|
gi 1775986642 418 PFLVGLLSSSLPkLKELPVEEALMVNLGSD 447
Cdd:pfam02141 158 PFIIGVHSRYFD-LLEDPLDDVVLVDLDTG 186
DENN smart00799
Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The ...
 264-447 3.90e-71

Domain found in a variety of signalling proteins, always encircled by uDENN and dDENN; The DENN domain is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214823  Cd Length: 183  Bit Score: 227.08  E-value: 3.90e-71
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775986642  264 LPEVYCVISRLGCFGLFSKVLDEVERRRGISAALVYPFMRSLMESPFPAPGKTIKVKTFLPGagnEVLELRRPMDSRLEH 343
Cdd:smart00799   1 APKCICILSRLPFFELFRKILNELYRLLPSSSNLPLELLISLLLYPVPPPGGSLVLVSLGPG---DLIELQRPLDSSLPL 77

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775986642  344 VDFEC--LFTCLSVRQLIRIFASLLLERRVIFVADKLSTLSSCSHAVVALLYPFSWQHTFIPVLPASMIDIVCCPTPFLV 421
Cdd:smart00799  78 IDFSLheLFECLGVENILQLFAALLLERRIIFTSSNLSTLSAVIEALLALLYPFVWQHIYIPILPASLLDVLSAPTPFII 157

                          170       180
                   ....*....|....*....|....*.
gi 1775986642  422 GLLSSSLPKLKELPVEEALMVNLGSD 447
Cdd:smart00799 158 GVHSSYFEEVKELPDEDVVVVDLDTG 183
uDENN smart00800
Domain always found upstream of DENN domain, found in a variety of signalling proteins; The ...
 169-256 1.77e-23

Domain always found upstream of DENN domain, found in a variety of signalling proteins; The uDENN domain is part of the tripartite DENN domain. It is always found upstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 214824  Cd Length: 89  Bit Score: 94.71  E-value: 1.77e-23
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775986642  169 FEYFVVVSLKKK--PSRNTYLPEVSYQFPKLDRptkqmrEAEERLKAIPQFCFPDAKDWLPVSEYS-SETFSFMLTGEDG 245
Cdd:smart00800   5 FDYFVVVGLDSDtgPLGRSYKPEILQRYPEKDF------EDFPLPDSIPLFCFPEGLDFVTQTSSKdPQFFSFVLTDIDG 78

                           90
                   ....*....|.
gi 1775986642  246 SRRFGYCRRLL 256
Cdd:smart00800  79 SRRYGFCLRFY 89
dDENN smart00801
Domain always found downstream of DENN domain, found in a variety of signalling proteins; The ...
 495-561 7.95e-16

Domain always found downstream of DENN domain, found in a variety of signalling proteins; The dDENN domain is part of the tripartite DENN domain. It is always found downstream of the DENN domain itself, which is found in a variety of signalling proteins involved in Rab-mediated processes or regulation of MAPKs signalling pathways. The DENN domain is always encircled on both sides by more divergent domains, called uDENN (for upstream DENN) and dDENN (for downstream DENN). The function of the DENN domain remains to date unclear, although it appears to represent a good candidate for a GTP/GDP exchange activity.


Pssm-ID: 129037  Cd Length: 69  Bit Score: 72.32  E-value: 7.95e-16
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775986642  495 NGLVSEVFIRFFVETVGHYSLFLTQSEK---GERAFQREAFRKSVASKSiRRFLEVFMESQMFAGFIQDR 561
Cdd:smart00801   1 NDEIREAFLRFFVNLFGGYRNFLRELRKepgPVITFDKESFLKSRPSSE-RPFLSKFLETQMFSQFIEER 69
uDENN pfam03456
uDENN domain; This region is always found associated with pfam02141. It is predicted to form ...
 188-254 2.65e-14

uDENN domain; This region is always found associated with pfam02141. It is predicted to form an all beta domain.


Pssm-ID: 460926  Cd Length: 59  Bit Score: 67.63  E-value: 2.65e-14
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1775986642 188 PEVSYQFPKLDRPTKQMreaeerLKAIPQFCFPDakDWLPVSEYSSETFSFMLTGEDGSRRFGYCRR 254
Cdd:pfam03456   1 PEVLDRYPEDDWSDPPL------PDGIPMFCFPE--GLETLSSREPTFFSFVLTDEDGSRLYGACLT 59
dDENN pfam03455
dDENN domain; This region is always found associated with pfam02141. It is predicted to form a ...
 527-575 8.10e-11

dDENN domain; This region is always found associated with pfam02141. It is predicted to form a globular domain. Although not statistically supported it has been suggested that this domain may be similar to members of the Rho/Rac/Cdc42 GEF family. This N-terminal region of DENN folds into a longin module, consisting of a central antiparallel beta-sheet layered between helix H1 and helices H2 and H3 (strands S1-S5). Rab35 interacts with dDENN via residues in helix 1 and in the loop S3-S4.


Pssm-ID: 460925  Cd Length: 48  Bit Score: 57.20  E-value: 8.10e-11
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1775986642 527 FQREAFRKSVASKSiRRFLEVFMESQMFAGFIQDRELRKCRAKGLFEQR 575
Cdd:pfam03455   1 FDKEAFLKSLPSDS-RPFLSQFLETQMFNEFIEERLESSDPSIDLFDEE 48
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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