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Conserved domains on  [gi|1775983612|ref|NP_001363454|]
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tetratricopeptide repeat protein 17 isoform 3 precursor [Homo sapiens]

Protein Classification

tetratricopeptide repeat protein( domain architecture ID 11419012)

tetratricopeptide repeat (TPR) protein may adopt a right-handed helical structure with an amphipathic channel and may function as an interaction scaffold in the formation of multi-protein complexes

CATH:  1.25.40.10
Gene Ontology:  GO:0005515
PubMed:  10517866|30708253
SCOP:  3001345

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
610-736 6.29e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.95  E-value: 6.29e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  610 AINKPNAPIWLILneaGLYWRAVGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEP 689
Cdd:COG0457     36 ELDPDDAEALYNL---GLAYLRLGRYEEALADYEQALELDPDDAE--ALNNLGLALQALGRYEEALEDYDKALELDPDDA 110

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1775983612  690 LTFLSLGNAYLALKNISGALEAFRQALKLTTKCPECENSLKLIRCMQ 736
Cdd:COG0457    111 EALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKL 157
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1063-1189 1.72e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.80  E-value: 1.72e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612 1063 KVLEKN-QTSWVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHQmkDVPLISLANILHNAKLWNDAVIVATMAVEIAPHF 1141
Cdd:COG0457     33 KALELDpDDAEALYNLGLAYLR-LGRYEEALADYEQALELDPDD--AEALNNLGLALQALGRYEEALEDYDKALELDPDD 109

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1775983612 1142 AVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTIQCHL 1189
Cdd:COG0457    110 AEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKL 157
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
226-406 1.35e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


:

Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.16  E-value: 1.35e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  226 WVLYNMASFYWRIKNEPyQVVECAMRALHFSSRHnkDIALVNLANVLHRAHFSADAAVVVHAALD-DSDFFTSYYTLGNI 304
Cdd:COG0457     43 EALYNLGLAYLRLGRYE-EALADYEQALELDPDD--AEALNNLGLALQALGRYEEALEDYDKALElDPDDAEALYNLGLA 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  305 YAMLGEYNHSVLCYDHALQARPGFEQAIKRKHAVLCQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQQEILEKHKL 384
Cdd:COG0457    120 LLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLAL 199

                          170       180
                   ....*....|....*....|..
gi 1775983612  385 IQEEQILRNIIHETQMAKEAQL 406
Cdd:COG0457    200 LLALEQALRKKLAILTLAALAE 221
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
610-736 6.29e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.95  E-value: 6.29e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  610 AINKPNAPIWLILneaGLYWRAVGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEP 689
Cdd:COG0457     36 ELDPDDAEALYNL---GLAYLRLGRYEEALADYEQALELDPDDAE--ALNNLGLALQALGRYEEALEDYDKALELDPDDA 110

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1775983612  690 LTFLSLGNAYLALKNISGALEAFRQALKLTTKCPECENSLKLIRCMQ 736
Cdd:COG0457    111 EALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKL 157
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1063-1189 1.72e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.80  E-value: 1.72e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612 1063 KVLEKN-QTSWVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHQmkDVPLISLANILHNAKLWNDAVIVATMAVEIAPHF 1141
Cdd:COG0457     33 KALELDpDDAEALYNLGLAYLR-LGRYEEALADYEQALELDPDD--AEALNNLGLALQALGRYEEALEDYDKALELDPDD 109

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1775983612 1142 AVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTIQCHL 1189
Cdd:COG0457    110 AEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKL 157
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
226-406 1.35e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.16  E-value: 1.35e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  226 WVLYNMASFYWRIKNEPyQVVECAMRALHFSSRHnkDIALVNLANVLHRAHFSADAAVVVHAALD-DSDFFTSYYTLGNI 304
Cdd:COG0457     43 EALYNLGLAYLRLGRYE-EALADYEQALELDPDD--AEALNNLGLALQALGRYEEALEDYDKALElDPDDAEALYNLGLA 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  305 YAMLGEYNHSVLCYDHALQARPGFEQAIKRKHAVLCQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQQEILEKHKL 384
Cdd:COG0457    120 LLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLAL 199

                          170       180
                   ....*....|....*....|..
gi 1775983612  385 IQEEQILRNIIHETQMAKEAQL 406
Cdd:COG0457    200 LLALEQALRKKLAILTLAALAE 221
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 573-738 3.10e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.54  E-value: 3.10e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  573 RMDLKAKMPDD--------------HARKIL-LSRINNYTIPEEEIGSFLFHAINKPNAPIWLILNEAGlYWRAVGNSTF 637
Cdd:TIGR02917  507 RIDIQEGNPDDaiqrfekvltidpkNLRAILaLAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQ-YYLGKGQLKK 585

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  638 AIACLQRALNLAPLQYQDVPLvnLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALKNISGALEAFRQALK 717
Cdd:TIGR02917  586 ALAILNEAADAAPDSPEAWLM--LGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALE 663

                          170       180
                   ....*....|....*....|.
gi 1775983612  718 LttkcpECENSLKLIRCMQFY 738
Cdd:TIGR02917  664 L-----KPDNTEAQIGLAQLL 679
TPR_12 pfam13424
Tetratricopeptide repeat;
658-721 1.05e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.60  E-value: 1.05e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1775983612  658 LVNLANLLIHYGLHLDATKLLLQALAINSSEP--------LTFLSLGNAYLALKNISGALEAFRQALKLTTK 721
Cdd:pfam13424    6 LNNLAAVLRRLGRYDEALELLEKALEIARRLLgpdhpltaTTLLNLGRLYLELGRYEEALELLERALALAEK 77
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 329-410 5.50e-04

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 43.33  E-value: 5.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  329 EQAIKRKHAVL--CQQKLEQKLEAQHRSLQRTLNELKE-YQKQHDHYLRQQEILEKHKLIQEEQILRNIIHETQMAKEAQ 405
Cdd:cd16269    207 AEAAEQERKLLeeQQRELEQKLEDQERSYEEHLRQLKEkMEEERENLLKEQERALESKLKEQEALLEEGFKEQAELLQEE 286


                   ....*
gi 1775983612  406 LGNHQ 410
Cdd:cd16269    287 IRSLK 291
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1039-1173 1.35e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.15  E-value: 1.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612 1039 EVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTSWV-LSSMAALYWRVKgQGKKAIDCLRQALHYAPHQmkDVPLISLANI 1117
Cdd:TIGR02917  602 EAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALaLLLLADAYAVMK-NYAKAITSLKRALELKPDN--TEAQIGLAQL 678

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1775983612 1118 LHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQP 1173
Cdd:TIGR02917  679 LLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAP 734
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 689-718 1.84e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 37.04  E-value: 1.84e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 1775983612   689 PLTFLSLGNAYLALKNISGALEAFRQALKL 718
Cdd:smart00028    1 AEALYNLGNAYLKLGDYDEALEYYEKALEL 30
TPR_1 pfam00515
Tetratricopeptide repeat;
1145-1175 3.28e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 36.24  E-value: 3.28e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1775983612 1145 HFTLGNVYVAMEEFEKALVWYESTLKLQPEF 1175
Cdd:pfam00515    4 LYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 1145-1175 3.60e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.27  E-value: 3.60e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1775983612  1145 HFTLGNVYVAMEEFEKALVWYESTLKLQPEF 1175
Cdd:smart00028    4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR_1 pfam00515
Tetratricopeptide repeat;
297-328 7.81e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 35.09  E-value: 7.81e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1775983612  297 SYYTLGNIYAMLGEYNHSVLCYDHALQARPGF 328
Cdd:pfam00515    3 ALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
 
Name Accession Description Interval E-value
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
610-736 6.29e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.95  E-value: 6.29e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  610 AINKPNAPIWLILneaGLYWRAVGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEP 689
Cdd:COG0457     36 ELDPDDAEALYNL---GLAYLRLGRYEEALADYEQALELDPDDAE--ALNNLGLALQALGRYEEALEDYDKALELDPDDA 110

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*..
gi 1775983612  690 LTFLSLGNAYLALKNISGALEAFRQALKLTTKCPECENSLKLIRCMQ 736
Cdd:COG0457    111 EALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKL 157
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
610-729 8.72e-12

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 66.57  E-value: 8.72e-12
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  610 AINKPNAPIWLILneaGLYWRAVGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEP 689
Cdd:COG0457      2 ELDPDDAEAYNNL---GLAYRRLGRYEEAIEDYEKALELDPDDAE--ALYNLGLAYLRLGRYEEALADYEQALELDPDDA 76

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|
gi 1775983612  690 LTFLSLGNAYLALKNISGALEAFRQALKLTTKCPECENSL 729
Cdd:COG0457     77 EALNNLGLALQALGRYEEALEDYDKALELDPDDAEALYNL 116
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 621-724 1.57e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 68.48  E-value: 1.57e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  621 ILNEAGLYWRAVGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYL 700
Cdd:COG3914     80 LLELAALLLQALGRYEEALALYRRALALNPDNAE--ALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALR 157

                           90       100
                   ....*....|....*....|....
gi 1775983612  701 ALKNISGALEAFRQALKLTTKCPE 724
Cdd:COG3914    158 RLGRLEEAIAALRRALELDPDNAE 181
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1063-1189 1.72e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 65.80  E-value: 1.72e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612 1063 KVLEKN-QTSWVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHQmkDVPLISLANILHNAKLWNDAVIVATMAVEIAPHF 1141
Cdd:COG0457     33 KALELDpDDAEALYNLGLAYLR-LGRYEEALADYEQALELDPDD--AEALNNLGLALQALGRYEEALEDYDKALELDPDD 109

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|....*...
gi 1775983612 1142 AVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTIQCHL 1189
Cdd:COG0457    110 AEALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALEKL 157
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 610-718 4.42e-11

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 67.33  E-value: 4.42e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  610 AINKPNAPIWLILNEAglyWRAVGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEP 689
Cdd:COG3914    106 ALNPDNAEALFNLGNL---LLALGRLEEALAALRRALALNPDFAE--AYLNLGEALRRLGRLEEAIAALRRALELDPDNA 180

                           90       100
                   ....*....|....*....|....*....
gi 1775983612  690 LTFLSLGNAYLALKNISGALEAFRQALKL 718
Cdd:COG3914    181 EALNNLGNALQDLGRLEEAIAAYRRALEL 209
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1072-1178 5.33e-11

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 64.26  E-value: 5.33e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612 1072 WVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHQmkDVPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNV 1151
Cdd:COG0457      9 EAYNNLGLAYRR-LGRYEEAIEDYEKALELDPDD--AEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNLGLA 85

                           90       100
                   ....*....|....*....|....*..
gi 1775983612 1152 YVAMEEFEKALVWYESTLKLQPEFVPA 1178
Cdd:COG0457     86 LQALGRYEEALEDYDKALELDPDDAEA 112
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 615-718 7.04e-11

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 61.18  E-value: 7.04e-11
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  615 NAPIWLILneaGLYWRAVGNSTFAIACLQRALNLAPlQYQDVpLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLS 694
Cdd:COG4235     16 DAEGWLLL---GRAYLRLGRYDEALAAYEKALRLDP-DNADA-LLDLAEALLAAGDTEEAEELLERALALDPDNPEALYL 90

                           90       100
                   ....*....|....*....|....
gi 1775983612  695 LGNAYLALKNISGALEAFRQALKL 718
Cdd:COG4235     91 LGLAAFQQGDYAEAIAAWQKLLAL 114
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1063-1178 1.08e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 60.90  E-value: 1.08e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612 1063 KVLEKN-QTSWVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHQMKdvPLISLANILHNAKLWNDAVIVATMAVEIAPHF 1141
Cdd:COG2956     67 KLLERDpDRAEALLELAQDYLK-AGLLDRAEELLEKLLELDPDDAE--ALRLLAEIYEQEGDWEKAIEVLERLLKLGPEN 143

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1775983612 1142 AVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPA 1178
Cdd:COG2956    144 AHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARA 180
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1017-1178 1.22e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 62.70  E-value: 1.22e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612 1017 LDHLHGVSNRASLHYTGESQLTEVLQNLGKDQYPQQSLEQIgtriakvLEKN-QTSWVLSSMAALYwRVKGQGKKAIDCL 1095
Cdd:COG3914     64 AGEAAAAAAALLLLAALLELAALLLQALGRYEEALALYRRA-------LALNpDNAEALFNLGNLL-LALGRLEEALAAL 135

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612 1096 RQALHYAPHQMKdvPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEF 1175
Cdd:COG3914    136 RRALALNPDFAE--AYLNLGEALRRLGRLEEAIAALRRALELDPDNAEALNNLGNALQDLGRLEEAIAAYRRALELDPDN 213


                   ...
gi 1775983612 1176 VPA 1178
Cdd:COG3914    214 ADA 216
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 622-724 2.00e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 57.12  E-value: 2.00e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  622 LNEAGLYWRAVGNSTFAIACLQRALNLAPlqYQDVPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLA 701
Cdd:COG4783      7 LYALAQALLLAGDYDEAEALLEKALELDP--DNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLK 84

                           90       100
                   ....*....|....*....|...
gi 1775983612  702 LKNISGALEAFRQALKLTTKCPE 724
Cdd:COG4783     85 AGDYDEALALLEKALKLDPEHPE 107
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1034-1185 2.44e-09

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 59.74  E-value: 2.44e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612 1034 ESQLTEVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTS-WVLSSMAALYwRVKGQGKKAIDCLRQALHYAPHQMkdVPLI 1112
Cdd:COG2956     72 DPDRAEALLELAQDYLKAGLLDRAEELLEKLLELDPDDaEALRLLAEIY-EQEGDWEKAIEVLERLLKLGPENA--HAYC 148

                           90       100       110       120       130       140       150
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 1775983612 1113 SLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQTI 1185
Cdd:COG2956    149 ELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALEQDPDYLPALPRLAEL 221
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 633-718 2.72e-09

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 57.28  E-value: 2.72e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  633 GNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALKNISGALEAF 712
Cdd:COG5010     68 GDFEESLALLEQALQLDPNNPE--LYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAAL 145


                   ....*.
gi 1775983612  713 RQALKL 718
Cdd:COG5010    146 QRALGT 151
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1035-1175 6.49e-09

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 55.58  E-value: 6.49e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612 1035 SQLTEVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTS-WVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHQmkDVPLIS 1113
Cdd:COG4783      1 AACAEALYALAQALLLAGDYDEAEALLEKALELDPDNpEAFALLGEILLQ-LGDLDEAIVLLHEALELDPDE--PEARLN 77

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1775983612 1114 LANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEF 1175
Cdd:COG4783     78 LGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALELDPDD 139
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 1077-1182 9.35e-09

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 59.62  E-value: 9.35e-09
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612 1077 MAALYWRVKGQGKKAIDCLRQALHYAPHQMKdvPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAME 1156
Cdd:COG3914     83 LAALLLQALGRYEEALALYRRALALNPDNAE--ALFNLGNLLLALGRLEEALAALRRALALNPDFAEAYLNLGEALRRLG 160

                           90       100
                   ....*....|....*....|....*.
gi 1775983612 1157 EFEKALVWYESTLKLQPEFVPAKNRI 1182
Cdd:COG3914    161 RLEEAIAALRRALELDPDNAEALNNL 186
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1079-1185 1.75e-08

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 54.43  E-value: 1.75e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612 1079 ALYWRVKGQGKKAIDCLRQALHYAPHQMkdVPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEF 1158
Cdd:COG4783     11 AQALLLAGDYDEAEALLEKALELDPDNP--EAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNLGLALLKAGDY 88

                           90       100
                   ....*....|....*....|....*..
gi 1775983612 1159 EKALVWYESTLKLQPEFVPAKNRIQTI 1185
Cdd:COG4783     89 DEALALLEKALKLDPEHPEAYLRLARA 115
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
615-724 2.10e-08

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 56.08  E-value: 2.10e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  615 NAPIWLILNEAGLYWRAVGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLS 694
Cdd:COG4785     69 LPDLAQLYYERGVAYDSLGDYDLAIADFDQALELDPDLAE--AYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYAYLN 146

                           90       100       110
                   ....*....|....*....|....*....|
gi 1775983612  695 LGNAYLALKNISGALEAFRQALKLTTKCPE 724
Cdd:COG4785    147 RGIALYYLGRYELAIADLEKALELDPNDPE 176
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
621-717 5.35e-08

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 55.40  E-value: 5.35e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  621 ILNEAGLYWRAVGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYL 700
Cdd:COG0457     78 ALNNLGLALQALGRYEEALEDYDKALELDPDDAE--ALYNLGLALLELGRYDEAIEAYERALELDPDDADALYNLGIALE 155

                           90
                   ....*....|....*..
gi 1775983612  701 ALKNISGALEAFRQALK 717
Cdd:COG0457    156 KLGRYEEALELLEKLEA 172
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
1085-1174 7.17e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 51.32  E-value: 7.17e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612 1085 KGQGKKAIDCLRQALHYAPHQMkdVPLISLANILHNAKLWNDAvIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVW 1164
Cdd:COG3063      5 LGDLEEAEEYYEKALELDPDNA--DALNNLGLLLLEQGRYDEA-IALEKALKLDPNNAEALLNLAELLLELGDYDEALAY 81

                           90
                   ....*....|
gi 1775983612 1165 YESTLKLQPE 1174
Cdd:COG3063     82 LERALELDPS 91
PilF COG3063
Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];
628-719 7.24e-08

Type IV pilus assembly protein PilF/PilW [Cell motility, Extracellular structures];


Pssm-ID: 442297 [Multi-domain]  Cd Length: 94  Bit Score: 51.32  E-value: 7.24e-08
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  628 YWRAVGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLlQALAINSSEPLTFLSLGNAYLALKNISG 707
Cdd:COG3063      1 LYLKLGDLEEAEEYYEKALELDPDNAD--ALNNLGLLLLEQGRYDEAIALE-KALKLDPNNAEALLNLAELLLELGDYDE 77

                           90
                   ....*....|..
gi 1775983612  708 ALEAFRQALKLT 719
Cdd:COG3063     78 ALAYLERALELD 89
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 1067-1178 2.07e-07

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 51.16  E-value: 2.07e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612 1067 KNQTSWVLssMAALYWRvKGQGKKAIDCLRQALHYAPhQMKDVpLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHF 1146
Cdd:COG4235     15 NDAEGWLL--LGRAYLR-LGRYDEALAAYEKALRLDP-DNADA-LLDLAEALLAAGDTEEAEELLERALALDPDNPEALY 89

                           90       100       110
                   ....*....|....*....|....*....|..
gi 1775983612 1147 TLGNVYVAMEEFEKALVWYESTLKLQPEFVPA 1178
Cdd:COG4235     90 LLGLAAFQQGDYAEAIAAWQKLLALLPADAPA 121
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 638-718 3.30e-07

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 50.58  E-value: 3.30e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  638 AIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALKNISGALEAFRQALK 717
Cdd:COG4783     57 AIVLLHEALELDPDEPE--ARLNLGLALLKAGDYDEALALLEKALKLDPEHPEAYLRLARAYRALGRPDEAIAALEKALE 134


                   .
gi 1775983612  718 L 718
Cdd:COG4783    135 L 135
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1111-1182 4.35e-07

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 52.70  E-value: 4.35e-07
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1775983612 1111 LISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRI 1182
Cdd:COG0457     11 YNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLGRYEEALADYEQALELDPDDAEALNNL 82
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1085-1173 4.36e-07

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 50.73  E-value: 4.36e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612 1085 KGQGKKAIDCLRQALHYAPHQMKdvPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVW 1164
Cdd:COG5010     67 LGDFEESLALLEQALQLDPNNPE--LYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSLGQDDEAKAA 144


                   ....*....
gi 1775983612 1165 YESTLKLQP 1173
Cdd:COG5010    145 LQRALGTSP 153
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1063-1174 8.76e-07

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 52.04  E-value: 8.76e-07
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612 1063 KVLEKN-QTSWVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHqmKDVPLISLANILHNAKLWNDAVIVATMAVEIAPHF 1141
Cdd:COG2956     33 EALELDpETVEAHLALGNLYRR-RGEYDRAIRIHQKLLERDPD--RAEALLELAQDYLKAGLLDRAEELLEKLLELDPDD 109

                           90       100       110
                   ....*....|....*....|....*....|...
gi 1775983612 1142 AVNHFTLGNVYVAMEEFEKALVWYESTLKLQPE 1174
Cdd:COG2956    110 AEALRLLAEIYEQEGDWEKAIEVLERLLKLGPE 142
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1063-1183 1.17e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.16  E-value: 1.17e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612 1063 KVLEKN-QTSWVLSSMAALYWRvKGQGKKAIDCLRQALHYAPHQMKdvPLISLANILHNAKLWNDAVIVATMAVEIAPHF 1141
Cdd:COG0457     67 QALELDpDDAEALNNLGLALQA-LGRYEEALEDYDKALELDPDDAE--ALYNLGLALLELGRYDEAIEAYERALELDPDD 143

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1775983612 1142 AVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIQ 1183
Cdd:COG0457    144 ADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGE 185
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
226-406 1.35e-06

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 51.16  E-value: 1.35e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  226 WVLYNMASFYWRIKNEPyQVVECAMRALHFSSRHnkDIALVNLANVLHRAHFSADAAVVVHAALD-DSDFFTSYYTLGNI 304
Cdd:COG0457     43 EALYNLGLAYLRLGRYE-EALADYEQALELDPDD--AEALNNLGLALQALGRYEEALEDYDKALElDPDDAEALYNLGLA 119

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  305 YAMLGEYNHSVLCYDHALQARPGFEQAIKRKHAVLCQQKLEQKLEAQHRSLQRTLNELKEYQKQHDHYLRQQEILEKHKL 384
Cdd:COG0457    120 LLELGRYDEAIEAYERALELDPDDADALYNLGIALEKLGRYEEALELLEKLEAAALAALLAAALGEAALALAAAEVLLAL 199

                          170       180
                   ....*....|....*....|..
gi 1775983612  385 IQEEQILRNIIHETQMAKEAQL 406
Cdd:COG0457    200 LLALEQALRKKLAILTLAALAE 221
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 1090-1178 1.38e-06

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 48.85  E-value: 1.38e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612 1090 KAIDCLRQALHYAPhqmKDVP-LISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYEST 1168
Cdd:COG4235      1 EAIARLRQALAANP---NDAEgWLLLGRAYLRLGRYDEALAAYEKALRLDPDNADALLDLAEALLAAGDTEEAEELLERA 77

                           90
                   ....*....|
gi 1775983612 1169 LKLQPEFVPA 1178
Cdd:COG4235     78 LALDPDNPEA 87
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 1077-1193 1.63e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 51.27  E-value: 1.63e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612 1077 MAALYWRVKGQGKKAIDCLRQALHYAPHQMKdvPLISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAME 1156
Cdd:COG2956     13 FKGLNYLLNGQPDKAIDLLEEALELDPETVE--AHLALGNLYRRRGEYDRAIRIHQKLLERDPDRAEALLELAQDYLKAG 90

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1775983612 1157 EFEKALVWYESTLKLQPEFVPAKNRIqtIQCHLMLKK 1193
Cdd:COG2956     91 LLDRAEELLEKLLELDPDDAEALRLL--AEIYEQEGD 125
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 609-725 1.68e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 50.88  E-value: 1.68e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  609 HAINKPNAPIWLILneAGLYWRAvGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSE 688
Cdd:COG2956     35 LELDPETVEAHLAL--GNLYRRR-GEYDRAIRIHQKLLERDPDRAE--ALLELAQDYLKAGLLDRAEELLEKLLELDPDD 109

                           90       100       110
                   ....*....|....*....|....*....|....*..
gi 1775983612  689 PLTFLSLGNAYLALKNISGALEAFRQALKLTTKCPEC 725
Cdd:COG2956    110 AEALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHA 146
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 622-718 3.88e-06

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 51.15  E-value: 3.88e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  622 LNEAGLYWRAVGNSTFAIACLQRALNLAPLQYQDvplvnlANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLA 701
Cdd:COG3914     51 LAEAAAAALLALAAGEAAAAAAALLLLAALLELA------ALLLQALGRYEEALALYRRALALNPDNAEALFNLGNLLLA 124

                           90
                   ....*....|....*..
gi 1775983612  702 LKNISGALEAFRQALKL 718
Cdd:COG3914    125 LGRLEEALAALRRALAL 141
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 638-718 6.37e-06

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 49.34  E-value: 6.37e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  638 AIACLQRALNLAPlqYQDVPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALKNISGALEAFRQALK 717
Cdd:COG2956    129 AIEVLERLLKLGP--ENAHAYCELAELYLEQGDYDEAIEALEKALKLDPDCARALLLLAELYLEQGDYEEAIAALERALE 206


                   .
gi 1775983612  718 L 718
Cdd:COG2956    207 Q 207
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 610-719 1.27e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 48.19  E-value: 1.27e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  610 AINKPNAPIWLILneAGLYWRAvGNSTFAIACLQRALNLAPlqyQDVP-LVNLANLLIHYGLHLDATKLLLQALAINSSE 688
Cdd:COG2956    138 KLGPENAHAYCEL--AELYLEQ-GDYDEAIEALEKALKLDP---DCARaLLLLAELYLEQGDYEEAIAALERALEQDPDY 211

                           90       100       110
                   ....*....|....*....|....*....|.
gi 1775983612  689 PLTFLSLGNAYLALKNISGALEAFRQALKLT 719
Cdd:COG2956    212 LPALPRLAELYEKLGDPEEALELLRKALELD 242
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 625-724 1.99e-05

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 47.80  E-value: 1.99e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  625 AGLYWRAvGNSTFAIACLQRALNLAPLQYQdvPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALKN 704
Cdd:COG2956     83 AQDYLKA-GLLDRAEELLEKLLELDPDDAE--ALRLLAEIYEQEGDWEKAIEVLERLLKLGPENAHAYCELAELYLEQGD 159

                           90       100
                   ....*....|....*....|
gi 1775983612  705 ISGALEAFRQALKLTTKCPE 724
Cdd:COG2956    160 YDEAIEALEKALKLDPDCAR 179
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 573-738 3.10e-05

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 48.54  E-value: 3.10e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  573 RMDLKAKMPDD--------------HARKIL-LSRINNYTIPEEEIGSFLFHAINKPNAPIWLILNEAGlYWRAVGNSTF 637
Cdd:TIGR02917  507 RIDIQEGNPDDaiqrfekvltidpkNLRAILaLAGLYLRTGNEEEAVAWLEKAAELNPQEIEPALALAQ-YYLGKGQLKK 585

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  638 AIACLQRALNLAPLQYQDVPLvnLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALKNISGALEAFRQALK 717
Cdd:TIGR02917  586 ALAILNEAADAAPDSPEAWLM--LGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNYAKAITSLKRALE 663

                          170       180
                   ....*....|....*....|.
gi 1775983612  718 LttkcpECENSLKLIRCMQFY 738
Cdd:TIGR02917  664 L-----KPDNTEAQIGLAQLL 679
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 622-736 4.00e-05

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 45.34  E-value: 4.00e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  622 LNEAGLYWRAVGNSTFAIACLQRALNLAPLQYQDVPLVNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLA 701
Cdd:COG5010     21 RTLVEKYEAALAGANNTKEDELAAAGRDKLAKAFAIESPSDNLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSR 100

                           90       100       110
                   ....*....|....*....|....*....|....*
gi 1775983612  702 LKNISGALEAFRQALKLTTKCPECENSLKLIRCMQ 736
Cdd:COG5010    101 SGDKDEAKEYYEKALALSPDNPNAYSNLAALLLSL 135
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
643-718 5.97e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 45.68  E-value: 5.97e-05
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1775983612  643 QRALNLAPLQYqdvplvNLANLLIHYGLHLDATKLLLQALAINSSEPLTFLSLGNAYLALKNISGALEAFRQALKL 718
Cdd:COG4785     67 LALPDLAQLYY------ERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALEL 136
NlpI COG4785
Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];
1111-1178 6.78e-05

Lipoprotein NlpI, contains TPR repeats [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 443815 [Multi-domain]  Cd Length: 223  Bit Score: 45.68  E-value: 6.78e-05
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1775983612 1111 LISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPA 1178
Cdd:COG4785     76 YYERGVAYDSLGDYDLAIADFDQALELDPDLAEAYNNRGLAYLLLGDYDAALEDFDRALELDPDYAYA 143
TPR_12 pfam13424
Tetratricopeptide repeat;
658-721 1.05e-04

Tetratricopeptide repeat;


Pssm-ID: 315987 [Multi-domain]  Cd Length: 77  Bit Score: 41.60  E-value: 1.05e-04
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1775983612  658 LVNLANLLIHYGLHLDATKLLLQALAINSSEP--------LTFLSLGNAYLALKNISGALEAFRQALKLTTK 721
Cdd:pfam13424    6 LNNLAAVLRRLGRYDEALELLEKALEIARRLLgpdhpltaTTLLNLGRLYLELGRYEEALELLERALALAEK 77
Spy COG3914
Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational ...
 610-727 4.15e-04

Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443119 [Multi-domain]  Cd Length: 658  Bit Score: 44.60  E-value: 4.15e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  610 AINKPNAPIWLILNEAglyWRAVGNSTFAIACLQRALNLAPlQYQDVpLVNLANLLIHYGLHLDATKLLLQALAINSSEP 689
Cdd:COG3914    140 ALNPDFAEAYLNLGEA---LRRLGRLEEAIAALRRALELDP-DNAEA-LNNLGNALQDLGRLEEAIAAYRRALELDPDNA 214

                           90       100       110
                   ....*....|....*....|....*....|....*...
gi 1775983612  690 LTFLSLGNAYLALKNISGALEAFRQALKLTTKCPECEN 727
Cdd:COG3914    215 DAHSNLLFALRQACDWEVYDRFEELLAALARGPSELSP 252
GBP_C cd16269
Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal ...
 329-410 5.50e-04

Guanylate-binding protein, C-terminal domain; Guanylate-binding protein (GBP), C-terminal domain. Guanylate-binding proteins (GBPs) are synthesized after activation of the cell by interferons. The biochemical properties of GBPs are clearly different from those of Ras-like and heterotrimeric GTP-binding proteins. They bind guanine nucleotides with low affinity (micromolar range), are stable in their absence, and have a high turnover GTPase. In addition to binding GDP/GTP, they have the unique ability to bind GMP with equal affinity and hydrolyze GTP not only to GDP, but also to GMP. This C-terminal domain has been shown to mediate inhibition of endothelial cell proliferation by inflammatory cytokines.


Pssm-ID: 293879 [Multi-domain]  Cd Length: 291  Bit Score: 43.33  E-value: 5.50e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  329 EQAIKRKHAVL--CQQKLEQKLEAQHRSLQRTLNELKE-YQKQHDHYLRQQEILEKHKLIQEEQILRNIIHETQMAKEAQ 405
Cdd:cd16269    207 AEAAEQERKLLeeQQRELEQKLEDQERSYEEHLRQLKEkMEEERENLLKEQERALESKLKEQEALLEEGFKEQAELLQEE 286


                   ....*
gi 1775983612  406 LGNHQ 410
Cdd:cd16269    287 IRSLK 291
NrfG COG4235
Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, ...
 673-718 6.61e-04

Cytochrome c-type biogenesis protein CcmH/NrfG [Energy production and conversion, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443378 [Multi-domain]  Cd Length: 131  Bit Score: 41.14  E-value: 6.61e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*.
gi 1775983612  673 DATKLLLQALAINSSEPLTFLSLGNAYLALKNISGALEAFRQALKL 718
Cdd:COG4235      1 EAIARLRQALAANPNDAEGWLLLGRAYLRLGRYDEALAAYEKALRL 46
TadD COG5010
Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, ...
 1116-1180 7.79e-04

Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking, secretion, and vesicular transport, Extracellular structures];


Pssm-ID: 444034 [Multi-domain]  Cd Length: 155  Bit Score: 41.48  E-value: 7.79e-04
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1775983612 1116 NILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKN 1180
Cdd:COG5010     62 NLYNKLGDFEESLALLEQALQLDPNNPELYYNLALLYSRSGDKDEAKEYYEKALALSPDNPNAYS 126
ClassIIa_HDAC5_Gln-rich-N cd10164
Glutamine-rich N-terminal helical domain of HDAC5, a Class IIa histone deacetylase; This ...
 338-424 9.24e-04

Glutamine-rich N-terminal helical domain of HDAC5, a Class IIa histone deacetylase; This family consists of the glutamine-rich domain of histone deacetylase 5 (HDAC5). It belongs to a superfamily that consists of the glutamine-rich N-terminal helical extension to certain Class IIa histone deacetylases (HDACs), including HDAC4, HDAC5 and HDCA9; it is missing from HDAC7. This domain confers responsiveness to calcium signals and mediates interactions with transcription factors and cofactors, and it is able to repress transcription independently of the HDAC C-terminal, zinc-dependent catalytic domain. It has many intra- and inter-helical interactions which are possibly involved in reversible assembly and disassembly of proteins. HDACs regulate diverse cellular processes through enzymatic deacetylation of histone as well as non-histone proteins, in particular deacetylating N(6)-acetyl-lysine residues.


Pssm-ID: 197400 [Multi-domain]  Cd Length: 97  Bit Score: 39.81  E-value: 9.24e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  338 VLCQQKLEQKLEA--QHRSLQRTLnELKEYQKQHDHYLRQQEI-LEKHKLIQEEQILRNIIHETQMAKEAQLGNHQICRL 414
Cdd:cd10164      3 SLREQQLQQELLLlkQQQQLQKQL-LFAEFQKQHEHLTRQHEVqLQKHLKVRAELFSEQQQQEILAAKRQQELEQQRKRE 81

                           90
                   ....*....|
gi 1775983612  415 VNQQHSLHCQ 424
Cdd:cd10164     82 QQRQEELEKQ 91
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1039-1173 1.35e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 43.15  E-value: 1.35e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612 1039 EVLQNLGKDQYPQQSLEQIGTRIAKVLEKNQTSWV-LSSMAALYWRVKgQGKKAIDCLRQALHYAPHQmkDVPLISLANI 1117
Cdd:TIGR02917  602 EAWLMLGRAQLAAGDLNKAVSSFKKLLALQPDSALaLLLLADAYAVMK-NYAKAITSLKRALELKPDN--TEAQIGLAQL 678

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|....*.
gi 1775983612 1118 LHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQP 1173
Cdd:TIGR02917  679 LLAAKRTESAKKIAKSLQKQHPKAALGFELEGDLYLRQKDYPAAIQAYRKALKRAP 734
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 689-718 1.84e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 37.04  E-value: 1.84e-03
                            10        20        30
                    ....*....|....*....|....*....|
gi 1775983612   689 PLTFLSLGNAYLALKNISGALEAFRQALKL 718
Cdd:smart00028    1 AEALYNLGNAYLKLGDYDEALEYYEKALEL 30
BepA COG4783
Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell ...
 1111-1195 2.08e-03

Outer membrane protein chaperone/metalloprotease BepA/YfgC, contains M48 and TPR domains [Cell wall/membrane/envelope biogenesis, Posttranslational modification, protein turnover, chaperones];


Pssm-ID: 443813 [Multi-domain]  Cd Length: 139  Bit Score: 39.79  E-value: 2.08e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612 1111 LISLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRIqtiqCHLM 1190
Cdd:COG4783      7 LYALAQALLLAGDYDEAEALLEKALELDPDNPEAFALLGEILLQLGDLDEAIVLLHEALELDPDEPEARLNL----GLAL 82


                   ....*
gi 1775983612 1191 LKKGR 1195
Cdd:COG4783     83 LKAGD 87
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1061-1179 2.46e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 41.99  E-value: 2.46e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612 1061 IAKVLE---KNQTSWVLSsmaALYWRVKGQGKKAIDCLRQALHYAPHQMKdvPLISLANILHNAKLWNDAVIVATMAVEI 1137
Cdd:TIGR02917  182 IDEVLTadpGNVDALLLK---GDLLLSLGNIELALAAYRKAIALRPNNIA--VLLALATILIEAGEFEEAEKHADALLKK 256

                           90       100       110       120
                   ....*....|....*....|....*....|....*....|..
gi 1775983612 1138 APHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAK 1179
Cdd:TIGR02917  257 APNSPLAHYLKALVDFQKKNYEDARETLQDALKSAPEYLPAL 298
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
1135-1182 2.59e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 41.15  E-value: 2.59e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*...
gi 1775983612 1135 VEIAPHFAVNHFTLGNVYVAMEEFEKALVWYESTLKLQPEFVPAKNRI 1182
Cdd:COG0457      1 LELDPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNL 48
TPR_1 pfam00515
Tetratricopeptide repeat;
1145-1175 3.28e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 36.24  E-value: 3.28e-03
                           10        20        30
                   ....*....|....*....|....*....|.
gi 1775983612 1145 HFTLGNVYVAMEEFEKALVWYESTLKLQPEF 1175
Cdd:pfam00515    4 LYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR smart00028
Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum ...
 1145-1175 3.60e-03

Tetratricopeptide repeats; Repeats present in 4 or more copies in proteins. Contain a minimum of 34 amino acids each and self-associate via a "knobs and holes" mechanism.


Pssm-ID: 197478 [Multi-domain]  Cd Length: 34  Bit Score: 36.27  E-value: 3.60e-03
                            10        20        30
                    ....*....|....*....|....*....|.
gi 1775983612  1145 HFTLGNVYVAMEEFEKALVWYESTLKLQPEF 1175
Cdd:smart00028    4 LYNLGNAYLKLGDYDEALEYYEKALELDPNN 34
TPR_1 pfam00515
Tetratricopeptide repeat;
689-718 4.20e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 35.86  E-value: 4.20e-03
                           10        20        30
                   ....*....|....*....|....*....|
gi 1775983612  689 PLTFLSLGNAYLALKNISGALEAFRQALKL 718
Cdd:pfam00515    1 AKALYNLGNAYFKLGKYDEALEYYEKALEL 30
LapB COG2956
Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal ...
 610-717 4.57e-03

Lipopolysaccharide biosynthesis regulator YciM/LapB, contains six TPR domains and a C-terminal metal-binding domain [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442196 [Multi-domain]  Cd Length: 275  Bit Score: 40.48  E-value: 4.57e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612  610 AINKPNAPIWLILneaGLYWRAVGNSTFAIACLQRALNLAPlQYQDVpLVNLANLLIHYGLHLDATKLLLQALAINSSEP 689
Cdd:COG2956    172 KLDPDCARALLLL---AELYLEQGDYEEAIAALERALEQDP-DYLPA-LPRLAELYEKLGDPEEALELLRKALELDPSDD 246

                           90       100
                   ....*....|....*....|....*...
gi 1775983612  690 LtFLSLGNAYLALKNISGALEAFRQALK 717
Cdd:COG2956    247 L-LLALADLLERKEGLEAALALLERQLR 273
TPR COG0457
Tetratricopeptide (TPR) repeat [General function prediction only];
291-356 5.31e-03

Tetratricopeptide (TPR) repeat [General function prediction only];


Pssm-ID: 440225 [Multi-domain]  Cd Length: 245  Bit Score: 39.99  E-value: 5.31e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1775983612  291 DSDFFTSYYTLGNIYAMLGEYNHSVLCYDHALQARPGFEQAIKRKHAVLCQQ-KLEQKLEAQHRSLQ 356
Cdd:COG0457      4 DPDDAEAYNNLGLAYRRLGRYEEAIEDYEKALELDPDDAEALYNLGLAYLRLgRYEEALADYEQALE 70
TPR_1 pfam00515
Tetratricopeptide repeat;
297-328 7.81e-03

Tetratricopeptide repeat;


Pssm-ID: 459840 [Multi-domain]  Cd Length: 34  Bit Score: 35.09  E-value: 7.81e-03
                           10        20        30
                   ....*....|....*....|....*....|..
gi 1775983612  297 SYYTLGNIYAMLGEYNHSVLCYDHALQARPGF 328
Cdd:pfam00515    3 ALYNLGNAYFKLGKYDEALEYYEKALELNPNN 34
TPR_2 pfam07719
Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats ...
 695-718 8.11e-03

Tetratricopeptide repeat; This Pfam entry includes outlying Tetratricopeptide-like repeats (TPR) that are not matched by pfam00515.


Pssm-ID: 429619 [Multi-domain]  Cd Length: 33  Bit Score: 35.19  E-value: 8.11e-03
                           10        20
                   ....*....|....*....|....
gi 1775983612  695 LGNAYLALKNISGALEAFRQALKL 718
Cdd:pfam07719    7 LGLAYYKLGDYEEALEAYEKALEL 30
PEP_TPR_lipo TIGR02917
putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly ...
 1079-1179 9.49e-03

putative PEP-CTERM system TPR-repeat lipoprotein; This protein family occurs in strictly within a subset of Gram-negative bacterial species with the proposed PEP-CTERM/exosortase system, analogous to the LPXTG/sortase system common in Gram-positive bacteria. This protein occurs in a species if and only if a transmembrane histidine kinase (TIGR02916) and a DNA-binding response regulator (TIGR02915) also occur. The present of tetratricopeptide repeats (TPR) suggests protein-protein interaction, possibly for the regulation of PEP-CTERM protein expression, since many PEP-CTERM proteins in these genomes are preceded by a proposed DNA binding site for the response regulator.


Pssm-ID: 274350 [Multi-domain]  Cd Length: 899  Bit Score: 40.07  E-value: 9.49e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1775983612 1079 ALYWRVKGQGKKAIDCLRQALHYAPHQMKDVPLisLANILHNAKLWNDAVIVATMAVEIAPHFAVNHFTLGNVYVAMEEF 1158
Cdd:TIGR02917  574 AQYYLGKGQLKKALAILNEAADAAPDSPEAWLM--LGRAQLAAGDLNKAVSSFKKLLALQPDSALALLLLADAYAVMKNY 651

                           90       100
                   ....*....|....*....|.
gi 1775983612 1159 EKALVWYESTLKLQPEFVPAK 1179
Cdd:TIGR02917  652 AKAITSLKRALELKPDNTEAQ 672
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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