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Transcription-associated protein 1 [Caenorhabditis elegans]
Protein Classification
PIKK_TRRAP domain-containing protein ( domain architecture ID 10142426 )
PIKK_TRRAP domain-containing protein
List of domain hits
Name
Accession
Description
Interval
E-value
Tra1_ring
pfam20206 Tra1 HEAT repeat ring region; This entry represents part of the Tra1 protein composed of alpha ...
925-2793
0e+00
Tra1 HEAT repeat ring region; This entry represents part of the Tra1 protein composed of alpha solenoid repeats that form a ring region.
Pssm-ID: 466357
Cd Length: 1678
Bit Score: 1319.24
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 925 RILGK F GG A NR KL L NQ P QI L QVATL GD TVQSYINM EF srmgl DGNHSIH LPL SELMRVVADQM R YPADM ilnpspamips 1004
Cdd:pfam20206 1 RILGK L GG R NR RF L KE P PK L EYRDA GD EASLTVEL EF ----- GAPSDQT LPL DPAVDLAKRTL R SSTSL ----------- 64
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1005 T H MK K WCM EL S K AV L LAG L G S SG SP ITPS A N L PKI I KK LLE DF ------- D PN N RT T EVYT -- CPR E SDR ELF VN AL LAM 1075
Cdd:pfam20206 65 P H YR K QAF EL L K SA L ALL L D S DD SP DDLL A R L QAA I QP LLE VK ieseaps D LS N LN T DDSA ak AKA E EQE ELF KQ AL KGL 144
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1076 AYGIWN K D g F R HVYSK F FIKV LR Q F A L IGVL E Y IG GNGWM R HA - EE EG V L plcl D SS V MV DA LIIC LS ET S SSFII AG VM 1154
Cdd:pfam20206 145 FFAASI K E - L R AEALP F LKGL LR H F T L LELA E E IG PFKES R RR f NL EG P L ---- D PL V FI DA IVES LS SE S KELRD AG ES 219
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1155 S L RH I NE TL SLT L PDIDQMSKV -- P MCK YL MEKVFK LC HGP AWY ARS GG INA I GYMI E S -- FPR K F V M D FVIDV V DSIME 1230
Cdd:pfam20206 220 V L KL I LD TL VTL L GSKEVVDQL ne P LFH YL ASRFCH LC YEE AWY RKL GG CLG I RILL E R ld LGL K W V L D HQLEF V RALLF 299
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1231 V ILGTVE E IS SG SA D S A Y D C L KKMMR V YF ------- IKE EG QEEENLT L A T I f V SAISKHYFH SNE R VRE F A IGLMDHCM 1303
Cdd:pfam20206 300 V LKDMPP E VP SG NV D D A K D T L LFILK V CN tppkstp KTT EG TAKQRSK L N T L - V GLLVSELSS SNE I VRE T A QKALELLA 378
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1304 vh SRLAPSLDKFYYRF KE FF epe L MRVL T - TVPTMSLADAG G SL D GVQNYMFNC P DGFD F EKD mdm YK R Y L SHL L DI A QT 1382
Cdd:pfam20206 379 -- ELTGIPVTELLEPV KE RL --- L QPIF T k PLRALPFPMQI G HI D AITFCLSLR P PLLE F NEE --- LV R L L HEA L AL A DA 450
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1383 DTFT L NQ RN afkkcetcpshfl P PFPIT T HIDSM R ASALQC L VI A ydrmkkqyidkg IELG D EHK miei LALRSSKI tvd 1462
Cdd:pfam20206 451 EDAA L VG RN ------------- P QYKNL T QLIQL R VACIRL L SA A ------------ MACP D FLA ---- PKQVNTRN --- 498
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1463 qvyesdeswr R LMT V LLRAVTD R e T PE IAEKL H PS L LK V SPISTIIIATFGASYI R N I sga GDDSDSDRHISYNDIMKFK 1542
Cdd:pfam20206 499 ---------- R IIS V FFKSLYS R - S PE VVDAA H DG L KQ V LAQQQKLPKDLLQTGL R P I --- LMNLSDHKRLTVAGLEGLA 564
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1543 C L V EL NPK ilvt KMA V NLANQMV kykms D KI s R ILSV P SSFT E EE L DDF E ae KMKGIRELDM I GHTVKM L A gcpvt TFTE 1622
Cdd:pfam20206 565 R L L EL LTN ---- YFK V EIGEKLL ----- D HL - R KWAD P EMLQ E AS L KPL E -- ENEEVKIAAA I LNIFHL L P ----- PAAS 627
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1623 QIIV D ISRFAAHF E YAYSQD V LVNWIDDVTVI LN KS P KDVWK FFL S R es IL DP ARRSFI R R I IVYQSSG PLR Q E FMDT P E 1702
Cdd:pfam20206 628 KFLE D LVKLVIQL E AVLRRY V SSPFREPLAKY LN RY P EEAVE FFL E R -- LS DP RYSRLF R D I LKSPDAE PLR A E VSSK P S 705
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1703 YFEK L IDLDDE E NK D EDE rkiw DRDMFAFS IV DRIS K SC P E WL I S P N SPIPRIKK L FS ete FNE R YVVRALTE vkkfqee 1782
Cdd:pfam20206 706 RVSL L NIKLFL E TA D SKT ---- ALRYQGLL IV RTLV K LN P N WL P S N N DVLQALLQ L WR --- SLH R LQRLGNED ------- 771
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1783 iiv KRMTEHKYKVP KL I L NTF L R YLR L N IY D Y DL FIVIASC F NGNF VTD L SFLR EY L ET EV IP K VPLQWR R ELF LR IMQK 1862
Cdd:pfam20206 772 --- SLIHFQQLRES KL L L KIL L Q YLR Q N PD D I DL LFDLLEI F TLPT VTD F SFLR DF L YE EV AL K YSVEQK R AIL LR FLEM 848
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1863 F D t DP Q T AGT sm QH VKAL QY L VI P T L HWA FER YDTD E - I V GTAP ID DSD ssmdvdpagssd NLVARLTSVIDSHRNYLS D 1941
Cdd:pfam20206 849 F P - DP T T SQD -- LK VKAL RH L IN P I L AAS FER GESK E e L V DADV ID QLH ------------ AKIWKPLQLAGDDATFSD D 913
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1942 G MV I VFY QL C TL F V QN ASE H I hn NNCK K Q ggrlri L ML FAW PC L T myn HQ DPT MRYTGFFFL A NI IE R F TINR KIVLQV F 2021
Cdd:pfam20206 914 G LR I ELL QL S TL L V EY ASE L I -- GENR K D ------ L IK FAW NF L K --- LD DPT VKQAAYVLI A RF IE A F DTPP KIVLQV Y 982
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 2022 HQ L MTTY Q QDT R DQI R K A I DIL T PAL RT R M -- ED G HLQILSHV K K IL I EE C H NLQHVQ H VF Q MV VR NYRVY Y HV R LELLT 2099
Cdd:pfam20206 983 VA L LKAH Q PEG R ALV R Q A L DIL A PAL PK R L pe NP G YPTWVKWT K R IL V EE G H SIPQLV H IY Q LI VR HPDLF Y PN R ELFVP 1062
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 2100 PLLNGV Q RALVM PN SVL E nwq TR RH AV EIC E MV I K WE LF R TLKT D HII S DE E ALEV DKQ LDK L RTA SS TDR F DFEE A HNK 2179
Cdd:pfam20206 1063 HMVTSL Q KLGLP PN ATT E --- TR KL AV DLA E LI I R WE RR R SESM D VSE S SN E ESGG DKQ TVP L DSS SS PKS F ASSS A SAD 1139
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 2180 RD M --- PDAQRT I IKEHADVI VN M L V RF CM T FH qnsgssstsq SGNHGVE L TKKCQL LL RAA L R P SM W GE f VS FR L TMI E 2256
Cdd:pfam20206 1140 PT M gad DSSNYP I PLSLRETV VN F L I RF AC T ST ---------- EDSSSKG L SARALE LL KDL L S P DL W PD - VS IK L SFF E 1208
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 2257 K F L S ipndnalr NDIS S TAYANT I Q NA qht L DM L CNIIP V M P KTSLMTMMR QLQ RP L IQ CL NNG aq N F K MTRLVTQ I VS R 2336
Cdd:pfam20206 1209 K V L A -------- QTEV S ENSIPQ I C NA --- L EI L NIVLE V K P NAWIISNLS QLQ KL L EK CL KSD -- N P K IQEALRP I LK R 1275
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 2337 L LE KTN VSV N G LD --- E LEQLNQY I SRFLH E HFG SL L N C rnlsgpvl G V LG AF SLL RTICG H E P A Y L D HLM PS FV KV MER 2413
Cdd:pfam20206 1276 I LE ALP VSV E G SE dae E VSSFYKF I ETIIT E GLS SL T N T -------- G L LG TL SLL SAWAK H R P D Y I D PFI PS LM KV LQK 1347
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 2414 AA KEHLA yv ANSQD GNMVKNFF P D --- V AELL CACM EL VRP RV D H IS m E IK R SIVGG i IAE LI I KSN HDKIIQ T SVKLLG 2490
Cdd:pfam20206 1348 LV KEHLA -- ANSQD ASSSSASP P P fes T AELL IKTL EL LKL RV S H LG - E QR R WFLSA - LVQ LI E KSN DVELLR T ILDMVR 1423
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 2491 AM I ST Q DME F - TI LTVLP LLV RIQ S II vtk F KNCKD L I AD Y L VVVITVF E NSEYRN SE AGS RL WEG F FW GL K SSDP QT R E 2569
Cdd:pfam20206 1424 EW I KE Q TEG F p TI KEKAG LLV KMM S FE --- F RGDAA L S AD F L DLILDIY E DPALAR SE LTV RL EPA F LM GL R SSDP KI R K 1500
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 2570 KF SIVWEKTWPH matv DI A H R MK YI MQN Q D W SKFKHAF W L K F AL WGM L RTIA K RPTDPNNKRKKV I LLNC A T pwrtieya 2649
Cdd:pfam20206 1501 KF FAIFDNSLSR ---- SL A E R LL YI LGV Q N W ESLGDHY W I K Q AL DLL L GSVD K DNPLSLSESSAS I PSLT A L -------- 1568
1770 1780 1790 1800 1810 1820 1830 1840
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 2650 aklkdqpmevetemkree P E PMEVDEKDSQ DD SK D A gepkekekltlel LL A G QQEL LDE ASNYDFA D A LD TVS Q ITFA l 2729
Cdd:pfam20206 1569 ------------------ E E ADKEESYEME DD EL D K ------------- LL S G HRAF LDE LRSVTLG D L LD PLR Q LLHQ - 1616
1850 1860 1870 1880 1890 1900
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1799133889 2730 n ENQV T S K M WV V LF KSF WS S LS QS E I ED F T ALV VP FM S SGV H NN y Q TGVQDS V LAVW LE A V GDA 2793
Cdd:pfam20206 1617 - DSNL T H K L WV S LF PAA WS A LS RR E Q ED L T KAI VP LL S KDY H SK - Q ADKRPN V IQTL LE G V ARC 1678
Tra1_central
pfam20175 Tra1 HEAT repeat central region; This entry represents part of the Tra1 protein composed of ...
287-914
0e+00
Tra1 HEAT repeat central region; This entry represents part of the Tra1 protein composed of alpha solenoid repeats that forms the central region. This is named as central due to its position relative to the ring region.
Pssm-ID: 466326
Cd Length: 593
Bit Score: 672.03
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 287 D DF VS AQ SRF LSF VNIM ak IPA F MDLIMQNGPL L VSGTMQM L ER CP ADLI S V R R E V L M A LKYFT S G E MK S K F F P MLPR L I 366
Cdd:pfam20175 3 G DF IA AQ VKT LSF LAYL -- LRG F AEQLRPYQDK L PEIVVRL L QD CP PEAS S T R K E L L V A TRHIL S T E FR S G F V P HIDL L L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 367 A E E V VL GTG F T AI E H LR VFM Y Q MLADL L HH M R NSIDY E MITH V IFVFCRT LHDP NNSSQV Q I MSA R LL NS L AE S LC K M D S 446
Cdd:pfam20175 81 D E K V LI GTG V T SY E T LR PLA Y S MLADL I HH V R AELSI E QLSK V VSIYSKN LHDP TLPPSI Q T MSA K LL LN L VD S IV K K D D 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 447 H D TFQT RDLL IE ILE SH V A KLK T L AV Y HM P I L F Q QYGTEIDY E Y K SYE rdaekpgmnipkdtir G V PKRRI R RLS ID S VE 526
Cdd:pfam20175 161 K D PQEA RDLL VR ILE TF V E KLK S L NR Y YP P L L K Q HRKKKSEK E E K TSA ---------------- D V DADED R PAD ID T VE 224
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 527 E L EFLASE P ST sedadesggdpnklppptkegkktspeail TAMSTMTP P PLAIVE AR N L V K YIM H TC K FVTGQ LR IAR P 606
Cdd:pfam20175 225 Y L AIERAK P IE ------------------------------ GIQFPSPS P VDPLKD AR F L F K TLL H GL K TIIWG LR NCQ P 274
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 607 ------------ S QDMYHCSK E R D L F E RL LRY GV M C M D VFVL --- P T T RNQPQMH S SMRT K D EK DA LE SL A NV FT TI D H A 671
Cdd:pfam20175 275 tppqqnapsgwn S VARGLPPE E V D I F I RL FKE GV K C F D LYSI nkd P P T TASSSSI S RTSS K E EK EV LE LF A SI FT IL D P A 354
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 672 I F R E I F EKY M D FL I ERI Y n R N YP L QLMVNT FL VRNE V - P F FAS TM L S FL MS R MKL L EVSN - D K TMLYVK LFK II F S A IGA 749
Cdd:pfam20175 355 T F Q E V F TSR M P FL F ERI L - E N PA L LAIPQF FL SNDS V s P R FAS IL L R FL VD R LED L GAAD k K K SSVLLR LFK LA F M A VTL 433
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 750 NGSG lh GDKM L TSY LP EILKQ S TV LAL T A R EPLNYFLLLRALFRSIGGG AQDI LY GKF L Q LLP N LL QF LN K ltn L Q S CQ H 829
Cdd:pfam20175 434 FPEE -- NEAV L QPH LP KLILT S LK LAL K A K EPLNYFLLLRALFRSIGGG RFEL LY KEV L P LLP V LL EG LN R --- L L S SA H 508
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 830 R IQ MR E LFVELCLTVPVRLS S LLPYL P LLM D PLV C A M N G SP NI V T QGLRTLELCVDNL Q PE Y L LEN M L PV RGA LMQ G LW R 909
Cdd:pfam20175 509 R PS MR D LFVELCLTVPVRLS V LLPYL S LLM K PLV L A L N S SP EL V S QGLRTLELCVDNL T PE F L DPI M Q PV IDD LMQ A LW K 588
....*
gi 1799133889 910 VVSKA 914
Cdd:pfam20175 589 HLRPL 593
PIKK_TRRAP
cd05163 Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein; TRRAP belongs ...
3678-4017
1.01e-59
Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein; TRRAP belongs to the the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. It contains a FATC (FRAP, ATM and TRRAP, C-terminal) domain and has a large molecular weight. Unlike most PIKK proteins, however, it contains an inactive PI3K-like pseudokinase domain, which lacks the conserved residues necessary for ATP binding and catalytic activity. TRRAP also contains many motifs that may be critical for protein-protein interactions. TRRAP is a common component of many histone acetyltransferase (HAT) complexes, and is responsible for the recruitment of these complexes to chromatin during transcription, replication, and DNA repair. TRRAP also exists in non-HAT complexes such as the p400 and MRN complexes, which are implicated in ATP-dependent remodeling and DNA repair, respectively. The TRRAP pseudokinase domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and RIO kinases.
Pssm-ID: 270707
Cd Length: 252
Bit Score: 207.37
E-value: 1.01e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3678 LS RF E P NF EIV IKG G QVI R KIY IRG QT G KSAA F YLKKSVQD -- EPTN RV P Q M F KH L DH VL QTDR E SA RR H L HAPTVLQMR 3755
Cdd:cd05163 1 IA RF L P RV EIV RRH G TCY R RLT IRG HD G SKYP F LVQTPSAR hs RREE RV M Q L F RL L NR VL ERKK E TR RR N L QFHVPIVVP 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3756 VGQ kttly E V AS V QPYA mppdctrnypa S Q I DIVHP Y D vltatfngsyypddmvlhfferfaqssssigqplptptnqdg 3835
Cdd:cd05163 81 LSP ----- Q V RL V EDDP ----------- S Y I SLQDI Y E ------------------------------------------ 102
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3836 tvapprlteahhi K NI I YEDFARD M I P FRL L YD Y LTARY P D P VMYYAMK KQ LLHS LA VL S TIE Y HCN L TPMG P DQMMMTM 3915
Cdd:cd05163 103 ------------- K LE I LNEIQSK M V P ETI L SN Y FLRTM P S P SDLWLFR KQ FTLQ LA LS S FMT Y VLS L GNRT P HRILISR 169
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3916 N TG VLSNPSYRFE I RGGRS L H diq HFGHE VPFRLTPN LSILV G - VAQD G D L LW SM A A ASKC L MKK E pevimrplvwdefa 3994
Cdd:cd05163 170 S TG NVFMTDFLPS I NSQGP L L --- DNNEP VPFRLTPN IQHFI G p IGVE G L L TS SM M A IARA L TEP E -------------- 232
330 340
....*....|....*....|...
gi 1799133889 3995 NNTDCD ksr L QV F ACHASN S YIN 4017
Cdd:cd05163 233 YDLEQY --- L SL F VRDELI S WHK 252
Name
Accession
Description
Interval
E-value
Tra1_ring
pfam20206 Tra1 HEAT repeat ring region; This entry represents part of the Tra1 protein composed of alpha ...
925-2793
0e+00
Tra1 HEAT repeat ring region; This entry represents part of the Tra1 protein composed of alpha solenoid repeats that form a ring region.
Pssm-ID: 466357
Cd Length: 1678
Bit Score: 1319.24
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 925 RILGK F GG A NR KL L NQ P QI L QVATL GD TVQSYINM EF srmgl DGNHSIH LPL SELMRVVADQM R YPADM ilnpspamips 1004
Cdd:pfam20206 1 RILGK L GG R NR RF L KE P PK L EYRDA GD EASLTVEL EF ----- GAPSDQT LPL DPAVDLAKRTL R SSTSL ----------- 64
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1005 T H MK K WCM EL S K AV L LAG L G S SG SP ITPS A N L PKI I KK LLE DF ------- D PN N RT T EVYT -- CPR E SDR ELF VN AL LAM 1075
Cdd:pfam20206 65 P H YR K QAF EL L K SA L ALL L D S DD SP DDLL A R L QAA I QP LLE VK ieseaps D LS N LN T DDSA ak AKA E EQE ELF KQ AL KGL 144
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1076 AYGIWN K D g F R HVYSK F FIKV LR Q F A L IGVL E Y IG GNGWM R HA - EE EG V L plcl D SS V MV DA LIIC LS ET S SSFII AG VM 1154
Cdd:pfam20206 145 FFAASI K E - L R AEALP F LKGL LR H F T L LELA E E IG PFKES R RR f NL EG P L ---- D PL V FI DA IVES LS SE S KELRD AG ES 219
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1155 S L RH I NE TL SLT L PDIDQMSKV -- P MCK YL MEKVFK LC HGP AWY ARS GG INA I GYMI E S -- FPR K F V M D FVIDV V DSIME 1230
Cdd:pfam20206 220 V L KL I LD TL VTL L GSKEVVDQL ne P LFH YL ASRFCH LC YEE AWY RKL GG CLG I RILL E R ld LGL K W V L D HQLEF V RALLF 299
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1231 V ILGTVE E IS SG SA D S A Y D C L KKMMR V YF ------- IKE EG QEEENLT L A T I f V SAISKHYFH SNE R VRE F A IGLMDHCM 1303
Cdd:pfam20206 300 V LKDMPP E VP SG NV D D A K D T L LFILK V CN tppkstp KTT EG TAKQRSK L N T L - V GLLVSELSS SNE I VRE T A QKALELLA 378
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1304 vh SRLAPSLDKFYYRF KE FF epe L MRVL T - TVPTMSLADAG G SL D GVQNYMFNC P DGFD F EKD mdm YK R Y L SHL L DI A QT 1382
Cdd:pfam20206 379 -- ELTGIPVTELLEPV KE RL --- L QPIF T k PLRALPFPMQI G HI D AITFCLSLR P PLLE F NEE --- LV R L L HEA L AL A DA 450
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1383 DTFT L NQ RN afkkcetcpshfl P PFPIT T HIDSM R ASALQC L VI A ydrmkkqyidkg IELG D EHK miei LALRSSKI tvd 1462
Cdd:pfam20206 451 EDAA L VG RN ------------- P QYKNL T QLIQL R VACIRL L SA A ------------ MACP D FLA ---- PKQVNTRN --- 498
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1463 qvyesdeswr R LMT V LLRAVTD R e T PE IAEKL H PS L LK V SPISTIIIATFGASYI R N I sga GDDSDSDRHISYNDIMKFK 1542
Cdd:pfam20206 499 ---------- R IIS V FFKSLYS R - S PE VVDAA H DG L KQ V LAQQQKLPKDLLQTGL R P I --- LMNLSDHKRLTVAGLEGLA 564
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1543 C L V EL NPK ilvt KMA V NLANQMV kykms D KI s R ILSV P SSFT E EE L DDF E ae KMKGIRELDM I GHTVKM L A gcpvt TFTE 1622
Cdd:pfam20206 565 R L L EL LTN ---- YFK V EIGEKLL ----- D HL - R KWAD P EMLQ E AS L KPL E -- ENEEVKIAAA I LNIFHL L P ----- PAAS 627
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1623 QIIV D ISRFAAHF E YAYSQD V LVNWIDDVTVI LN KS P KDVWK FFL S R es IL DP ARRSFI R R I IVYQSSG PLR Q E FMDT P E 1702
Cdd:pfam20206 628 KFLE D LVKLVIQL E AVLRRY V SSPFREPLAKY LN RY P EEAVE FFL E R -- LS DP RYSRLF R D I LKSPDAE PLR A E VSSK P S 705
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1703 YFEK L IDLDDE E NK D EDE rkiw DRDMFAFS IV DRIS K SC P E WL I S P N SPIPRIKK L FS ete FNE R YVVRALTE vkkfqee 1782
Cdd:pfam20206 706 RVSL L NIKLFL E TA D SKT ---- ALRYQGLL IV RTLV K LN P N WL P S N N DVLQALLQ L WR --- SLH R LQRLGNED ------- 771
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1783 iiv KRMTEHKYKVP KL I L NTF L R YLR L N IY D Y DL FIVIASC F NGNF VTD L SFLR EY L ET EV IP K VPLQWR R ELF LR IMQK 1862
Cdd:pfam20206 772 --- SLIHFQQLRES KL L L KIL L Q YLR Q N PD D I DL LFDLLEI F TLPT VTD F SFLR DF L YE EV AL K YSVEQK R AIL LR FLEM 848
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1863 F D t DP Q T AGT sm QH VKAL QY L VI P T L HWA FER YDTD E - I V GTAP ID DSD ssmdvdpagssd NLVARLTSVIDSHRNYLS D 1941
Cdd:pfam20206 849 F P - DP T T SQD -- LK VKAL RH L IN P I L AAS FER GESK E e L V DADV ID QLH ------------ AKIWKPLQLAGDDATFSD D 913
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1942 G MV I VFY QL C TL F V QN ASE H I hn NNCK K Q ggrlri L ML FAW PC L T myn HQ DPT MRYTGFFFL A NI IE R F TINR KIVLQV F 2021
Cdd:pfam20206 914 G LR I ELL QL S TL L V EY ASE L I -- GENR K D ------ L IK FAW NF L K --- LD DPT VKQAAYVLI A RF IE A F DTPP KIVLQV Y 982
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 2022 HQ L MTTY Q QDT R DQI R K A I DIL T PAL RT R M -- ED G HLQILSHV K K IL I EE C H NLQHVQ H VF Q MV VR NYRVY Y HV R LELLT 2099
Cdd:pfam20206 983 VA L LKAH Q PEG R ALV R Q A L DIL A PAL PK R L pe NP G YPTWVKWT K R IL V EE G H SIPQLV H IY Q LI VR HPDLF Y PN R ELFVP 1062
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 2100 PLLNGV Q RALVM PN SVL E nwq TR RH AV EIC E MV I K WE LF R TLKT D HII S DE E ALEV DKQ LDK L RTA SS TDR F DFEE A HNK 2179
Cdd:pfam20206 1063 HMVTSL Q KLGLP PN ATT E --- TR KL AV DLA E LI I R WE RR R SESM D VSE S SN E ESGG DKQ TVP L DSS SS PKS F ASSS A SAD 1139
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 2180 RD M --- PDAQRT I IKEHADVI VN M L V RF CM T FH qnsgssstsq SGNHGVE L TKKCQL LL RAA L R P SM W GE f VS FR L TMI E 2256
Cdd:pfam20206 1140 PT M gad DSSNYP I PLSLRETV VN F L I RF AC T ST ---------- EDSSSKG L SARALE LL KDL L S P DL W PD - VS IK L SFF E 1208
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 2257 K F L S ipndnalr NDIS S TAYANT I Q NA qht L DM L CNIIP V M P KTSLMTMMR QLQ RP L IQ CL NNG aq N F K MTRLVTQ I VS R 2336
Cdd:pfam20206 1209 K V L A -------- QTEV S ENSIPQ I C NA --- L EI L NIVLE V K P NAWIISNLS QLQ KL L EK CL KSD -- N P K IQEALRP I LK R 1275
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 2337 L LE KTN VSV N G LD --- E LEQLNQY I SRFLH E HFG SL L N C rnlsgpvl G V LG AF SLL RTICG H E P A Y L D HLM PS FV KV MER 2413
Cdd:pfam20206 1276 I LE ALP VSV E G SE dae E VSSFYKF I ETIIT E GLS SL T N T -------- G L LG TL SLL SAWAK H R P D Y I D PFI PS LM KV LQK 1347
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 2414 AA KEHLA yv ANSQD GNMVKNFF P D --- V AELL CACM EL VRP RV D H IS m E IK R SIVGG i IAE LI I KSN HDKIIQ T SVKLLG 2490
Cdd:pfam20206 1348 LV KEHLA -- ANSQD ASSSSASP P P fes T AELL IKTL EL LKL RV S H LG - E QR R WFLSA - LVQ LI E KSN DVELLR T ILDMVR 1423
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 2491 AM I ST Q DME F - TI LTVLP LLV RIQ S II vtk F KNCKD L I AD Y L VVVITVF E NSEYRN SE AGS RL WEG F FW GL K SSDP QT R E 2569
Cdd:pfam20206 1424 EW I KE Q TEG F p TI KEKAG LLV KMM S FE --- F RGDAA L S AD F L DLILDIY E DPALAR SE LTV RL EPA F LM GL R SSDP KI R K 1500
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 2570 KF SIVWEKTWPH matv DI A H R MK YI MQN Q D W SKFKHAF W L K F AL WGM L RTIA K RPTDPNNKRKKV I LLNC A T pwrtieya 2649
Cdd:pfam20206 1501 KF FAIFDNSLSR ---- SL A E R LL YI LGV Q N W ESLGDHY W I K Q AL DLL L GSVD K DNPLSLSESSAS I PSLT A L -------- 1568
1770 1780 1790 1800 1810 1820 1830 1840
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 2650 aklkdqpmevetemkree P E PMEVDEKDSQ DD SK D A gepkekekltlel LL A G QQEL LDE ASNYDFA D A LD TVS Q ITFA l 2729
Cdd:pfam20206 1569 ------------------ E E ADKEESYEME DD EL D K ------------- LL S G HRAF LDE LRSVTLG D L LD PLR Q LLHQ - 1616
1850 1860 1870 1880 1890 1900
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1799133889 2730 n ENQV T S K M WV V LF KSF WS S LS QS E I ED F T ALV VP FM S SGV H NN y Q TGVQDS V LAVW LE A V GDA 2793
Cdd:pfam20206 1617 - DSNL T H K L WV S LF PAA WS A LS RR E Q ED L T KAI VP LL S KDY H SK - Q ADKRPN V IQTL LE G V ARC 1678
Tra1_central
pfam20175 Tra1 HEAT repeat central region; This entry represents part of the Tra1 protein composed of ...
287-914
0e+00
Tra1 HEAT repeat central region; This entry represents part of the Tra1 protein composed of alpha solenoid repeats that forms the central region. This is named as central due to its position relative to the ring region.
Pssm-ID: 466326
Cd Length: 593
Bit Score: 672.03
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 287 D DF VS AQ SRF LSF VNIM ak IPA F MDLIMQNGPL L VSGTMQM L ER CP ADLI S V R R E V L M A LKYFT S G E MK S K F F P MLPR L I 366
Cdd:pfam20175 3 G DF IA AQ VKT LSF LAYL -- LRG F AEQLRPYQDK L PEIVVRL L QD CP PEAS S T R K E L L V A TRHIL S T E FR S G F V P HIDL L L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 367 A E E V VL GTG F T AI E H LR VFM Y Q MLADL L HH M R NSIDY E MITH V IFVFCRT LHDP NNSSQV Q I MSA R LL NS L AE S LC K M D S 446
Cdd:pfam20175 81 D E K V LI GTG V T SY E T LR PLA Y S MLADL I HH V R AELSI E QLSK V VSIYSKN LHDP TLPPSI Q T MSA K LL LN L VD S IV K K D D 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 447 H D TFQT RDLL IE ILE SH V A KLK T L AV Y HM P I L F Q QYGTEIDY E Y K SYE rdaekpgmnipkdtir G V PKRRI R RLS ID S VE 526
Cdd:pfam20175 161 K D PQEA RDLL VR ILE TF V E KLK S L NR Y YP P L L K Q HRKKKSEK E E K TSA ---------------- D V DADED R PAD ID T VE 224
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 527 E L EFLASE P ST sedadesggdpnklppptkegkktspeail TAMSTMTP P PLAIVE AR N L V K YIM H TC K FVTGQ LR IAR P 606
Cdd:pfam20175 225 Y L AIERAK P IE ------------------------------ GIQFPSPS P VDPLKD AR F L F K TLL H GL K TIIWG LR NCQ P 274
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 607 ------------ S QDMYHCSK E R D L F E RL LRY GV M C M D VFVL --- P T T RNQPQMH S SMRT K D EK DA LE SL A NV FT TI D H A 671
Cdd:pfam20175 275 tppqqnapsgwn S VARGLPPE E V D I F I RL FKE GV K C F D LYSI nkd P P T TASSSSI S RTSS K E EK EV LE LF A SI FT IL D P A 354
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 672 I F R E I F EKY M D FL I ERI Y n R N YP L QLMVNT FL VRNE V - P F FAS TM L S FL MS R MKL L EVSN - D K TMLYVK LFK II F S A IGA 749
Cdd:pfam20175 355 T F Q E V F TSR M P FL F ERI L - E N PA L LAIPQF FL SNDS V s P R FAS IL L R FL VD R LED L GAAD k K K SSVLLR LFK LA F M A VTL 433
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 750 NGSG lh GDKM L TSY LP EILKQ S TV LAL T A R EPLNYFLLLRALFRSIGGG AQDI LY GKF L Q LLP N LL QF LN K ltn L Q S CQ H 829
Cdd:pfam20175 434 FPEE -- NEAV L QPH LP KLILT S LK LAL K A K EPLNYFLLLRALFRSIGGG RFEL LY KEV L P LLP V LL EG LN R --- L L S SA H 508
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 830 R IQ MR E LFVELCLTVPVRLS S LLPYL P LLM D PLV C A M N G SP NI V T QGLRTLELCVDNL Q PE Y L LEN M L PV RGA LMQ G LW R 909
Cdd:pfam20175 509 R PS MR D LFVELCLTVPVRLS V LLPYL S LLM K PLV L A L N S SP EL V S QGLRTLELCVDNL T PE F L DPI M Q PV IDD LMQ A LW K 588
....*
gi 1799133889 910 VVSKA 914
Cdd:pfam20175 589 HLRPL 593
PIKK_TRRAP
cd05163 Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein; TRRAP belongs ...
3678-4017
1.01e-59
Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein; TRRAP belongs to the the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. It contains a FATC (FRAP, ATM and TRRAP, C-terminal) domain and has a large molecular weight. Unlike most PIKK proteins, however, it contains an inactive PI3K-like pseudokinase domain, which lacks the conserved residues necessary for ATP binding and catalytic activity. TRRAP also contains many motifs that may be critical for protein-protein interactions. TRRAP is a common component of many histone acetyltransferase (HAT) complexes, and is responsible for the recruitment of these complexes to chromatin during transcription, replication, and DNA repair. TRRAP also exists in non-HAT complexes such as the p400 and MRN complexes, which are implicated in ATP-dependent remodeling and DNA repair, respectively. The TRRAP pseudokinase domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and RIO kinases.
Pssm-ID: 270707
Cd Length: 252
Bit Score: 207.37
E-value: 1.01e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3678 LS RF E P NF EIV IKG G QVI R KIY IRG QT G KSAA F YLKKSVQD -- EPTN RV P Q M F KH L DH VL QTDR E SA RR H L HAPTVLQMR 3755
Cdd:cd05163 1 IA RF L P RV EIV RRH G TCY R RLT IRG HD G SKYP F LVQTPSAR hs RREE RV M Q L F RL L NR VL ERKK E TR RR N L QFHVPIVVP 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3756 VGQ kttly E V AS V QPYA mppdctrnypa S Q I DIVHP Y D vltatfngsyypddmvlhfferfaqssssigqplptptnqdg 3835
Cdd:cd05163 81 LSP ----- Q V RL V EDDP ----------- S Y I SLQDI Y E ------------------------------------------ 102
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3836 tvapprlteahhi K NI I YEDFARD M I P FRL L YD Y LTARY P D P VMYYAMK KQ LLHS LA VL S TIE Y HCN L TPMG P DQMMMTM 3915
Cdd:cd05163 103 ------------- K LE I LNEIQSK M V P ETI L SN Y FLRTM P S P SDLWLFR KQ FTLQ LA LS S FMT Y VLS L GNRT P HRILISR 169
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3916 N TG VLSNPSYRFE I RGGRS L H diq HFGHE VPFRLTPN LSILV G - VAQD G D L LW SM A A ASKC L MKK E pevimrplvwdefa 3994
Cdd:cd05163 170 S TG NVFMTDFLPS I NSQGP L L --- DNNEP VPFRLTPN IQHFI G p IGVE G L L TS SM M A IARA L TEP E -------------- 232
330 340
....*....|....*....|...
gi 1799133889 3995 NNTDCD ksr L QV F ACHASN S YIN 4017
Cdd:cd05163 233 YDLEQY --- L SL F VRDELI S WHK 252
PI3Kc
smart00146 Phosphoinositide 3-kinase, catalytic domain; Phosphoinositide 3-kinase isoforms participate in ...
3710-4002
4.39e-56
Phosphoinositide 3-kinase, catalytic domain; Phosphoinositide 3-kinase isoforms participate in a variety of processes, including cell motility, the Ras pathway, vesicle trafficking and secretion, and apoptosis. These homologues may be either lipid kinases and/or protein kinases: the former phosphorylate the 3-position in the inositol ring of inositol phospholipids. The ataxia telangiectesia-mutated gene produced, the targets of rapamycin (TOR) and the DNA-dependent kinase have not been found to possess lipid kinase activity. Some of this family possess PI-4 kinase activities.
Pssm-ID: 214538 [Multi-domain]
Cd Length: 240
Bit Score: 196.37
E-value: 4.39e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3710 FYL K KSVQDEPTN RV P Q MFKHLDHV LQ T D R E SA RR H LH APTVLQMRV G Q K TT L Y EV A svqpyamp P DC T rnypasqidiv 3789
Cdd:smart00146 1 VIF K GGDDLRQDE RV L Q LLRLMNKL LQ K D K E TR RR D LH LRPYKVIPT G P K SG L I EV V -------- P NS T ----------- 61
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3790 hpydvltatfngsyypddmvlhfferfaqsss SIGQP L PTPTN Q D G T V APP R LTE A HHI K NIIYEDF A RDMI P FRL LYD Y 3869
Cdd:smart00146 62 -------------------------------- TLHEI L KEYRK Q K G K V LDL R SQT A TRL K KLELFLE A TGKF P DPV LYD W 109
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3870 L T ARY PDP - VM Y YAMK K QLLH S L A VL S T I E Y HCN L TPMGP D QM M MT m N TG V L SNPSYR F EIRG G RS L H diq H F GHE VPFR 3948
Cdd:smart00146 110 F T KKF PDP s ED Y FEAR K NFTR S C A GY S V I T Y ILG L GDRHN D NI M LD - K TG H L FHIDFG F ILGN G PK L F --- G F PER VPFR 185
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1799133889 3949 LTP NLSILV G VAQDGD L LW S MAAASKCLMK K EPEV IM RP L VWDEFANNT D CDKS 4002
Cdd:smart00146 186 LTP EMVDVM G DSGYFG L FR S LCERALRALR K NSNL IM SL L ELMLYDGLP D WRSG 239
TEL1
COG5032 Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms];
3654-4062
5.82e-07
Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms];
Pssm-ID: 227365 [Multi-domain]
Cd Length: 2105
Bit Score: 56.33
E-value: 5.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3654 LL NVLRAKNHT L MASNQTGQYISMLS RFEP NFEI V IKGG Q VI R KIY IRG QT GK SAA F YL K K --- SV QDE ptn RVP Q MFKH 3730
Cdd:COG5032 1743 LL LFHAFLEIK L PGQYLLDKPFVLIE RFEP EVSV V KSHL Q RP R RLT IRG SD GK LYS F IV K G gdd LR QDE --- LAL Q LIRL 1819
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3731 LDHV L QT D R E SA RR H L H aptvlqmrvgqkttlyevas VQ PY AMP P dctrny PASQID I VH py D V ltatfngsyy P DDMV L 3810
Cdd:COG5032 1820 MNKI L KK D K E TR RR D L W -------------------- IR PY KVI P ------ LSPGSG I IE -- W V ---------- P NSDT L 1861
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3811 H FFE R FAQSSSS I gqplpt PTN Q DGTV A P prlt EAHHI K NIIYED F ARDMIPFR -- L LYD YLTARY P D P VMYYAMKKQLL 3888
Cdd:COG5032 1862 H SIL R EYHKRKN I ------ SID Q EKKL A A ---- RLDNL K LLLKDE F FTKATLKS pp V LYD WFSESF P N P EDWLTARTNFA 1931
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3889 H SLAV L S T I E Y HCN L TPMG P DQMMMTMNT G - V LSNP - SYRFEIRG GR sl HD iqh F GHE VPFRLT P N LSILV GV - AQD G DL 3965
Cdd:COG5032 1932 R SLAV Y S V I G Y ILG L GDRH P GNILIDRSS G h V IHID f GFILFNAP GR -- FP --- F PEK VPFRLT R N IVEAM GV s GVE G SF 2006
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3966 LWSMAA A SK c LMK K EPEVI M R --- PL V W D EFAN -- NTD C DKSRLQVFACHASNSYINGVAS K L - RNTNSADA klr KDDCV 4039
Cdd:COG5032 2007 RELCET A FR - ALR K NADSL M N vle LF V R D PLIE wr RLP C FREIQNNEIVNVLERFRLKLSE K D a EKFVDLLI --- NKSVE 2082
410 420
....*....|....*....|...
gi 1799133889 4040 SLI SR A K D SDN LA R M PPTYHAWF 4062
Cdd:COG5032 2083 SLI TQ A T D PFQ LA T M YIGWMPFW 2105
PI3_PI4_kinase
pfam00454 Phosphatidylinositol 3- and 4-kinase; Some members of this family probably do not have lipid ...
3860-3962
1.04e-03
Phosphatidylinositol 3- and 4-kinase; Some members of this family probably do not have lipid kinase activity and are protein kinases,.
Pssm-ID: 395364 [Multi-domain]
Cd Length: 241
Bit Score: 43.86
E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3860 MI P FRL L YDYLTARY PD PVMYYAMK K QLLH S L A VL S TIE Y HCNLTPMGP D QMMMTMN TG V L snpsyr F E I RG G RS L H D IQ 3939
Cdd:pfam00454 103 LP P KVG L LQWFVKKS PD AEEWGEAR K NFVR S C A GY S VLD Y ILGNGDRHL D NILVDKT TG K L ------ F H I DF G LC L P D AG 176
90 100
....*....|....*....|....*.
gi 1799133889 3940 HFGH --- E VPFRLT PNLSILV G VAQ D 3962
Cdd:pfam00454 177 KDLP fpe K VPFRLT REMVYAM G PSG D 202
Name
Accession
Description
Interval
E-value
Tra1_ring
pfam20206 Tra1 HEAT repeat ring region; This entry represents part of the Tra1 protein composed of alpha ...
925-2793
0e+00
Tra1 HEAT repeat ring region; This entry represents part of the Tra1 protein composed of alpha solenoid repeats that form a ring region.
Pssm-ID: 466357
Cd Length: 1678
Bit Score: 1319.24
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 925 RILGK F GG A NR KL L NQ P QI L QVATL GD TVQSYINM EF srmgl DGNHSIH LPL SELMRVVADQM R YPADM ilnpspamips 1004
Cdd:pfam20206 1 RILGK L GG R NR RF L KE P PK L EYRDA GD EASLTVEL EF ----- GAPSDQT LPL DPAVDLAKRTL R SSTSL ----------- 64
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1005 T H MK K WCM EL S K AV L LAG L G S SG SP ITPS A N L PKI I KK LLE DF ------- D PN N RT T EVYT -- CPR E SDR ELF VN AL LAM 1075
Cdd:pfam20206 65 P H YR K QAF EL L K SA L ALL L D S DD SP DDLL A R L QAA I QP LLE VK ieseaps D LS N LN T DDSA ak AKA E EQE ELF KQ AL KGL 144
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1076 AYGIWN K D g F R HVYSK F FIKV LR Q F A L IGVL E Y IG GNGWM R HA - EE EG V L plcl D SS V MV DA LIIC LS ET S SSFII AG VM 1154
Cdd:pfam20206 145 FFAASI K E - L R AEALP F LKGL LR H F T L LELA E E IG PFKES R RR f NL EG P L ---- D PL V FI DA IVES LS SE S KELRD AG ES 219
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1155 S L RH I NE TL SLT L PDIDQMSKV -- P MCK YL MEKVFK LC HGP AWY ARS GG INA I GYMI E S -- FPR K F V M D FVIDV V DSIME 1230
Cdd:pfam20206 220 V L KL I LD TL VTL L GSKEVVDQL ne P LFH YL ASRFCH LC YEE AWY RKL GG CLG I RILL E R ld LGL K W V L D HQLEF V RALLF 299
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1231 V ILGTVE E IS SG SA D S A Y D C L KKMMR V YF ------- IKE EG QEEENLT L A T I f V SAISKHYFH SNE R VRE F A IGLMDHCM 1303
Cdd:pfam20206 300 V LKDMPP E VP SG NV D D A K D T L LFILK V CN tppkstp KTT EG TAKQRSK L N T L - V GLLVSELSS SNE I VRE T A QKALELLA 378
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1304 vh SRLAPSLDKFYYRF KE FF epe L MRVL T - TVPTMSLADAG G SL D GVQNYMFNC P DGFD F EKD mdm YK R Y L SHL L DI A QT 1382
Cdd:pfam20206 379 -- ELTGIPVTELLEPV KE RL --- L QPIF T k PLRALPFPMQI G HI D AITFCLSLR P PLLE F NEE --- LV R L L HEA L AL A DA 450
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1383 DTFT L NQ RN afkkcetcpshfl P PFPIT T HIDSM R ASALQC L VI A ydrmkkqyidkg IELG D EHK miei LALRSSKI tvd 1462
Cdd:pfam20206 451 EDAA L VG RN ------------- P QYKNL T QLIQL R VACIRL L SA A ------------ MACP D FLA ---- PKQVNTRN --- 498
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1463 qvyesdeswr R LMT V LLRAVTD R e T PE IAEKL H PS L LK V SPISTIIIATFGASYI R N I sga GDDSDSDRHISYNDIMKFK 1542
Cdd:pfam20206 499 ---------- R IIS V FFKSLYS R - S PE VVDAA H DG L KQ V LAQQQKLPKDLLQTGL R P I --- LMNLSDHKRLTVAGLEGLA 564
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1543 C L V EL NPK ilvt KMA V NLANQMV kykms D KI s R ILSV P SSFT E EE L DDF E ae KMKGIRELDM I GHTVKM L A gcpvt TFTE 1622
Cdd:pfam20206 565 R L L EL LTN ---- YFK V EIGEKLL ----- D HL - R KWAD P EMLQ E AS L KPL E -- ENEEVKIAAA I LNIFHL L P ----- PAAS 627
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1623 QIIV D ISRFAAHF E YAYSQD V LVNWIDDVTVI LN KS P KDVWK FFL S R es IL DP ARRSFI R R I IVYQSSG PLR Q E FMDT P E 1702
Cdd:pfam20206 628 KFLE D LVKLVIQL E AVLRRY V SSPFREPLAKY LN RY P EEAVE FFL E R -- LS DP RYSRLF R D I LKSPDAE PLR A E VSSK P S 705
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1703 YFEK L IDLDDE E NK D EDE rkiw DRDMFAFS IV DRIS K SC P E WL I S P N SPIPRIKK L FS ete FNE R YVVRALTE vkkfqee 1782
Cdd:pfam20206 706 RVSL L NIKLFL E TA D SKT ---- ALRYQGLL IV RTLV K LN P N WL P S N N DVLQALLQ L WR --- SLH R LQRLGNED ------- 771
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1783 iiv KRMTEHKYKVP KL I L NTF L R YLR L N IY D Y DL FIVIASC F NGNF VTD L SFLR EY L ET EV IP K VPLQWR R ELF LR IMQK 1862
Cdd:pfam20206 772 --- SLIHFQQLRES KL L L KIL L Q YLR Q N PD D I DL LFDLLEI F TLPT VTD F SFLR DF L YE EV AL K YSVEQK R AIL LR FLEM 848
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1863 F D t DP Q T AGT sm QH VKAL QY L VI P T L HWA FER YDTD E - I V GTAP ID DSD ssmdvdpagssd NLVARLTSVIDSHRNYLS D 1941
Cdd:pfam20206 849 F P - DP T T SQD -- LK VKAL RH L IN P I L AAS FER GESK E e L V DADV ID QLH ------------ AKIWKPLQLAGDDATFSD D 913
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 1942 G MV I VFY QL C TL F V QN ASE H I hn NNCK K Q ggrlri L ML FAW PC L T myn HQ DPT MRYTGFFFL A NI IE R F TINR KIVLQV F 2021
Cdd:pfam20206 914 G LR I ELL QL S TL L V EY ASE L I -- GENR K D ------ L IK FAW NF L K --- LD DPT VKQAAYVLI A RF IE A F DTPP KIVLQV Y 982
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 2022 HQ L MTTY Q QDT R DQI R K A I DIL T PAL RT R M -- ED G HLQILSHV K K IL I EE C H NLQHVQ H VF Q MV VR NYRVY Y HV R LELLT 2099
Cdd:pfam20206 983 VA L LKAH Q PEG R ALV R Q A L DIL A PAL PK R L pe NP G YPTWVKWT K R IL V EE G H SIPQLV H IY Q LI VR HPDLF Y PN R ELFVP 1062
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 2100 PLLNGV Q RALVM PN SVL E nwq TR RH AV EIC E MV I K WE LF R TLKT D HII S DE E ALEV DKQ LDK L RTA SS TDR F DFEE A HNK 2179
Cdd:pfam20206 1063 HMVTSL Q KLGLP PN ATT E --- TR KL AV DLA E LI I R WE RR R SESM D VSE S SN E ESGG DKQ TVP L DSS SS PKS F ASSS A SAD 1139
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 2180 RD M --- PDAQRT I IKEHADVI VN M L V RF CM T FH qnsgssstsq SGNHGVE L TKKCQL LL RAA L R P SM W GE f VS FR L TMI E 2256
Cdd:pfam20206 1140 PT M gad DSSNYP I PLSLRETV VN F L I RF AC T ST ---------- EDSSSKG L SARALE LL KDL L S P DL W PD - VS IK L SFF E 1208
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 2257 K F L S ipndnalr NDIS S TAYANT I Q NA qht L DM L CNIIP V M P KTSLMTMMR QLQ RP L IQ CL NNG aq N F K MTRLVTQ I VS R 2336
Cdd:pfam20206 1209 K V L A -------- QTEV S ENSIPQ I C NA --- L EI L NIVLE V K P NAWIISNLS QLQ KL L EK CL KSD -- N P K IQEALRP I LK R 1275
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 2337 L LE KTN VSV N G LD --- E LEQLNQY I SRFLH E HFG SL L N C rnlsgpvl G V LG AF SLL RTICG H E P A Y L D HLM PS FV KV MER 2413
Cdd:pfam20206 1276 I LE ALP VSV E G SE dae E VSSFYKF I ETIIT E GLS SL T N T -------- G L LG TL SLL SAWAK H R P D Y I D PFI PS LM KV LQK 1347
1530 1540 1550 1560 1570 1580 1590 1600
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 2414 AA KEHLA yv ANSQD GNMVKNFF P D --- V AELL CACM EL VRP RV D H IS m E IK R SIVGG i IAE LI I KSN HDKIIQ T SVKLLG 2490
Cdd:pfam20206 1348 LV KEHLA -- ANSQD ASSSSASP P P fes T AELL IKTL EL LKL RV S H LG - E QR R WFLSA - LVQ LI E KSN DVELLR T ILDMVR 1423
1610 1620 1630 1640 1650 1660 1670 1680
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 2491 AM I ST Q DME F - TI LTVLP LLV RIQ S II vtk F KNCKD L I AD Y L VVVITVF E NSEYRN SE AGS RL WEG F FW GL K SSDP QT R E 2569
Cdd:pfam20206 1424 EW I KE Q TEG F p TI KEKAG LLV KMM S FE --- F RGDAA L S AD F L DLILDIY E DPALAR SE LTV RL EPA F LM GL R SSDP KI R K 1500
1690 1700 1710 1720 1730 1740 1750 1760
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 2570 KF SIVWEKTWPH matv DI A H R MK YI MQN Q D W SKFKHAF W L K F AL WGM L RTIA K RPTDPNNKRKKV I LLNC A T pwrtieya 2649
Cdd:pfam20206 1501 KF FAIFDNSLSR ---- SL A E R LL YI LGV Q N W ESLGDHY W I K Q AL DLL L GSVD K DNPLSLSESSAS I PSLT A L -------- 1568
1770 1780 1790 1800 1810 1820 1830 1840
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 2650 aklkdqpmevetemkree P E PMEVDEKDSQ DD SK D A gepkekekltlel LL A G QQEL LDE ASNYDFA D A LD TVS Q ITFA l 2729
Cdd:pfam20206 1569 ------------------ E E ADKEESYEME DD EL D K ------------- LL S G HRAF LDE LRSVTLG D L LD PLR Q LLHQ - 1616
1850 1860 1870 1880 1890 1900
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1799133889 2730 n ENQV T S K M WV V LF KSF WS S LS QS E I ED F T ALV VP FM S SGV H NN y Q TGVQDS V LAVW LE A V GDA 2793
Cdd:pfam20206 1617 - DSNL T H K L WV S LF PAA WS A LS RR E Q ED L T KAI VP LL S KDY H SK - Q ADKRPN V IQTL LE G V ARC 1678
Tra1_central
pfam20175 Tra1 HEAT repeat central region; This entry represents part of the Tra1 protein composed of ...
287-914
0e+00
Tra1 HEAT repeat central region; This entry represents part of the Tra1 protein composed of alpha solenoid repeats that forms the central region. This is named as central due to its position relative to the ring region.
Pssm-ID: 466326
Cd Length: 593
Bit Score: 672.03
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 287 D DF VS AQ SRF LSF VNIM ak IPA F MDLIMQNGPL L VSGTMQM L ER CP ADLI S V R R E V L M A LKYFT S G E MK S K F F P MLPR L I 366
Cdd:pfam20175 3 G DF IA AQ VKT LSF LAYL -- LRG F AEQLRPYQDK L PEIVVRL L QD CP PEAS S T R K E L L V A TRHIL S T E FR S G F V P HIDL L L 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 367 A E E V VL GTG F T AI E H LR VFM Y Q MLADL L HH M R NSIDY E MITH V IFVFCRT LHDP NNSSQV Q I MSA R LL NS L AE S LC K M D S 446
Cdd:pfam20175 81 D E K V LI GTG V T SY E T LR PLA Y S MLADL I HH V R AELSI E QLSK V VSIYSKN LHDP TLPPSI Q T MSA K LL LN L VD S IV K K D D 160
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 447 H D TFQT RDLL IE ILE SH V A KLK T L AV Y HM P I L F Q QYGTEIDY E Y K SYE rdaekpgmnipkdtir G V PKRRI R RLS ID S VE 526
Cdd:pfam20175 161 K D PQEA RDLL VR ILE TF V E KLK S L NR Y YP P L L K Q HRKKKSEK E E K TSA ---------------- D V DADED R PAD ID T VE 224
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 527 E L EFLASE P ST sedadesggdpnklppptkegkktspeail TAMSTMTP P PLAIVE AR N L V K YIM H TC K FVTGQ LR IAR P 606
Cdd:pfam20175 225 Y L AIERAK P IE ------------------------------ GIQFPSPS P VDPLKD AR F L F K TLL H GL K TIIWG LR NCQ P 274
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 607 ------------ S QDMYHCSK E R D L F E RL LRY GV M C M D VFVL --- P T T RNQPQMH S SMRT K D EK DA LE SL A NV FT TI D H A 671
Cdd:pfam20175 275 tppqqnapsgwn S VARGLPPE E V D I F I RL FKE GV K C F D LYSI nkd P P T TASSSSI S RTSS K E EK EV LE LF A SI FT IL D P A 354
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 672 I F R E I F EKY M D FL I ERI Y n R N YP L QLMVNT FL VRNE V - P F FAS TM L S FL MS R MKL L EVSN - D K TMLYVK LFK II F S A IGA 749
Cdd:pfam20175 355 T F Q E V F TSR M P FL F ERI L - E N PA L LAIPQF FL SNDS V s P R FAS IL L R FL VD R LED L GAAD k K K SSVLLR LFK LA F M A VTL 433
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 750 NGSG lh GDKM L TSY LP EILKQ S TV LAL T A R EPLNYFLLLRALFRSIGGG AQDI LY GKF L Q LLP N LL QF LN K ltn L Q S CQ H 829
Cdd:pfam20175 434 FPEE -- NEAV L QPH LP KLILT S LK LAL K A K EPLNYFLLLRALFRSIGGG RFEL LY KEV L P LLP V LL EG LN R --- L L S SA H 508
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 830 R IQ MR E LFVELCLTVPVRLS S LLPYL P LLM D PLV C A M N G SP NI V T QGLRTLELCVDNL Q PE Y L LEN M L PV RGA LMQ G LW R 909
Cdd:pfam20175 509 R PS MR D LFVELCLTVPVRLS V LLPYL S LLM K PLV L A L N S SP EL V S QGLRTLELCVDNL T PE F L DPI M Q PV IDD LMQ A LW K 588
....*
gi 1799133889 910 VVSKA 914
Cdd:pfam20175 589 HLRPL 593
PIKK_TRRAP
cd05163 Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein; TRRAP belongs ...
3678-4017
1.01e-59
Pseudokinase domain of TRansformation/tRanscription domain-Associated Protein; TRRAP belongs to the the phosphoinositide 3-kinase-related protein kinase (PIKK) subfamily. It contains a FATC (FRAP, ATM and TRRAP, C-terminal) domain and has a large molecular weight. Unlike most PIKK proteins, however, it contains an inactive PI3K-like pseudokinase domain, which lacks the conserved residues necessary for ATP binding and catalytic activity. TRRAP also contains many motifs that may be critical for protein-protein interactions. TRRAP is a common component of many histone acetyltransferase (HAT) complexes, and is responsible for the recruitment of these complexes to chromatin during transcription, replication, and DNA repair. TRRAP also exists in non-HAT complexes such as the p400 and MRN complexes, which are implicated in ATP-dependent remodeling and DNA repair, respectively. The TRRAP pseudokinase domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and RIO kinases.
Pssm-ID: 270707
Cd Length: 252
Bit Score: 207.37
E-value: 1.01e-59
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3678 LS RF E P NF EIV IKG G QVI R KIY IRG QT G KSAA F YLKKSVQD -- EPTN RV P Q M F KH L DH VL QTDR E SA RR H L HAPTVLQMR 3755
Cdd:cd05163 1 IA RF L P RV EIV RRH G TCY R RLT IRG HD G SKYP F LVQTPSAR hs RREE RV M Q L F RL L NR VL ERKK E TR RR N L QFHVPIVVP 80
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3756 VGQ kttly E V AS V QPYA mppdctrnypa S Q I DIVHP Y D vltatfngsyypddmvlhfferfaqssssigqplptptnqdg 3835
Cdd:cd05163 81 LSP ----- Q V RL V EDDP ----------- S Y I SLQDI Y E ------------------------------------------ 102
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3836 tvapprlteahhi K NI I YEDFARD M I P FRL L YD Y LTARY P D P VMYYAMK KQ LLHS LA VL S TIE Y HCN L TPMG P DQMMMTM 3915
Cdd:cd05163 103 ------------- K LE I LNEIQSK M V P ETI L SN Y FLRTM P S P SDLWLFR KQ FTLQ LA LS S FMT Y VLS L GNRT P HRILISR 169
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3916 N TG VLSNPSYRFE I RGGRS L H diq HFGHE VPFRLTPN LSILV G - VAQD G D L LW SM A A ASKC L MKK E pevimrplvwdefa 3994
Cdd:cd05163 170 S TG NVFMTDFLPS I NSQGP L L --- DNNEP VPFRLTPN IQHFI G p IGVE G L L TS SM M A IARA L TEP E -------------- 232
330 340
....*....|....*....|...
gi 1799133889 3995 NNTDCD ksr L QV F ACHASN S YIN 4017
Cdd:cd05163 233 YDLEQY --- L SL F VRDELI S WHK 252
PI3Kc
smart00146 Phosphoinositide 3-kinase, catalytic domain; Phosphoinositide 3-kinase isoforms participate in ...
3710-4002
4.39e-56
Phosphoinositide 3-kinase, catalytic domain; Phosphoinositide 3-kinase isoforms participate in a variety of processes, including cell motility, the Ras pathway, vesicle trafficking and secretion, and apoptosis. These homologues may be either lipid kinases and/or protein kinases: the former phosphorylate the 3-position in the inositol ring of inositol phospholipids. The ataxia telangiectesia-mutated gene produced, the targets of rapamycin (TOR) and the DNA-dependent kinase have not been found to possess lipid kinase activity. Some of this family possess PI-4 kinase activities.
Pssm-ID: 214538 [Multi-domain]
Cd Length: 240
Bit Score: 196.37
E-value: 4.39e-56
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3710 FYL K KSVQDEPTN RV P Q MFKHLDHV LQ T D R E SA RR H LH APTVLQMRV G Q K TT L Y EV A svqpyamp P DC T rnypasqidiv 3789
Cdd:smart00146 1 VIF K GGDDLRQDE RV L Q LLRLMNKL LQ K D K E TR RR D LH LRPYKVIPT G P K SG L I EV V -------- P NS T ----------- 61
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3790 hpydvltatfngsyypddmvlhfferfaqsss SIGQP L PTPTN Q D G T V APP R LTE A HHI K NIIYEDF A RDMI P FRL LYD Y 3869
Cdd:smart00146 62 -------------------------------- TLHEI L KEYRK Q K G K V LDL R SQT A TRL K KLELFLE A TGKF P DPV LYD W 109
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3870 L T ARY PDP - VM Y YAMK K QLLH S L A VL S T I E Y HCN L TPMGP D QM M MT m N TG V L SNPSYR F EIRG G RS L H diq H F GHE VPFR 3948
Cdd:smart00146 110 F T KKF PDP s ED Y FEAR K NFTR S C A GY S V I T Y ILG L GDRHN D NI M LD - K TG H L FHIDFG F ILGN G PK L F --- G F PER VPFR 185
250 260 270 280 290
....*....|....*....|....*....|....*....|....*....|....
gi 1799133889 3949 LTP NLSILV G VAQDGD L LW S MAAASKCLMK K EPEV IM RP L VWDEFANNT D CDKS 4002
Cdd:smart00146 186 LTP EMVDVM G DSGYFG L FR S LCERALRALR K NSNL IM SL L ELMLYDGLP D WRSG 239
PIKKc
cd05164 Catalytic domain of Phosphoinositide 3-kinase-related protein kinases; PIKK subfamily members ...
3680-3996
1.79e-12
Catalytic domain of Phosphoinositide 3-kinase-related protein kinases; PIKK subfamily members include ATM (Ataxia telangiectasia mutated), ATR (Ataxia telangiectasia and Rad3-related), TOR (Target of rapamycin), SMG-1 (Suppressor of morphogenetic effect on genitalia-1), and DNA-PK (DNA-dependent protein kinase). PIKKs have intrinsic serine/threonine kinase activity and are distinguished from other PKs by their unique catalytic domain, similar to that of lipid PI3K, and their large molecular weight (240-470 kDa). They show strong preference for phosphorylating serine/threonine residues followed by a glutamine and are also referred to as (S/T)-Q-directed kinases. They all contain a FATC (FRAP, ATM and TRRAP, C-terminal) domain. PIKKs have diverse functions including cell-cycle checkpoints, genome surveillance, mRNA surveillance, and translation control. The PIKK catalytic domain subfamily is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs), aminoglycoside phosphotransferase, choline kinase, and RIO kinases.
Pssm-ID: 270708 [Multi-domain]
Cd Length: 222
Bit Score: 69.61
E-value: 1.79e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3680 R F E P NFE I V i KGG Q VIR KI Y I R G QT GK SAA F YL K K --- SVQ DE ptn RV P Q M F KH L DHV L QT D R E SAR R H L HAP T VLQMRV 3756
Cdd:cd05164 3 S F D P RVR I L - ASL Q KPK KI T I L G SD GK EYP F LV K G ddd LRK DE --- RV M Q L F QL L NTL L EK D K E TRK R N L TIR T YSVVPL 78
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3757 GQKTT L Y E vasvqpyamppdctrnypasqidivhpydvltatfngsyypddmvlhfferfaqssssigqplptptnqdgt 3836
Cdd:cd05164 79 SSQSG L I E ------------------------------------------------------------------------ 86
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3837 vapprlteahhikniiyed FARDMIPFR - L L YDYLTARY PDP VMY Y AMKKQLLH S L AV L S TIE Y HCN L TPMGPDQMMMTM 3915
Cdd:cd05164 87 ------------------- WVDNTTTLK p V L KKWFNETF PDP TQW Y EARSNYTK S T AV M S MVG Y IIG L GDRHLENILIDT 147
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3916 N TG VLSNPSYRFEIRG G RS L HDIQ hfgh E VPFRLT P N LSILV G V - AQD G DLLW S MAAASKC l MK K EPEVIMR pl VW D E F A 3994
Cdd:cd05164 148 K TG EVVHIDFGMIFNK G KT L PVPE ---- I VPFRLT R N IINGM G P t GVE G LFRK S CEQVLRV - FR K HKDKLIT -- FL D T F L 220
..
gi 1799133889 3995 NN 3996
Cdd:cd05164 221 YD 222
TEL1
COG5032 Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms];
3654-4062
5.82e-07
Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms];
Pssm-ID: 227365 [Multi-domain]
Cd Length: 2105
Bit Score: 56.33
E-value: 5.82e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3654 LL NVLRAKNHT L MASNQTGQYISMLS RFEP NFEI V IKGG Q VI R KIY IRG QT GK SAA F YL K K --- SV QDE ptn RVP Q MFKH 3730
Cdd:COG5032 1743 LL LFHAFLEIK L PGQYLLDKPFVLIE RFEP EVSV V KSHL Q RP R RLT IRG SD GK LYS F IV K G gdd LR QDE --- LAL Q LIRL 1819
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3731 LDHV L QT D R E SA RR H L H aptvlqmrvgqkttlyevas VQ PY AMP P dctrny PASQID I VH py D V ltatfngsyy P DDMV L 3810
Cdd:COG5032 1820 MNKI L KK D K E TR RR D L W -------------------- IR PY KVI P ------ LSPGSG I IE -- W V ---------- P NSDT L 1861
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3811 H FFE R FAQSSSS I gqplpt PTN Q DGTV A P prlt EAHHI K NIIYED F ARDMIPFR -- L LYD YLTARY P D P VMYYAMKKQLL 3888
Cdd:COG5032 1862 H SIL R EYHKRKN I ------ SID Q EKKL A A ---- RLDNL K LLLKDE F FTKATLKS pp V LYD WFSESF P N P EDWLTARTNFA 1931
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3889 H SLAV L S T I E Y HCN L TPMG P DQMMMTMNT G - V LSNP - SYRFEIRG GR sl HD iqh F GHE VPFRLT P N LSILV GV - AQD G DL 3965
Cdd:COG5032 1932 R SLAV Y S V I G Y ILG L GDRH P GNILIDRSS G h V IHID f GFILFNAP GR -- FP --- F PEK VPFRLT R N IVEAM GV s GVE G SF 2006
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3966 LWSMAA A SK c LMK K EPEVI M R --- PL V W D EFAN -- NTD C DKSRLQVFACHASNSYINGVAS K L - RNTNSADA klr KDDCV 4039
Cdd:COG5032 2007 RELCET A FR - ALR K NADSL M N vle LF V R D PLIE wr RLP C FREIQNNEIVNVLERFRLKLSE K D a EKFVDLLI --- NKSVE 2082
410 420
....*....|....*....|...
gi 1799133889 4040 SLI SR A K D SDN LA R M PPTYHAWF 4062
Cdd:COG5032 2083 SLI TQ A T D PFQ LA T M YIGWMPFW 2105
PI3_PI4_kinase
pfam00454 Phosphatidylinositol 3- and 4-kinase; Some members of this family probably do not have lipid ...
3860-3962
1.04e-03
Phosphatidylinositol 3- and 4-kinase; Some members of this family probably do not have lipid kinase activity and are protein kinases,.
Pssm-ID: 395364 [Multi-domain]
Cd Length: 241
Bit Score: 43.86
E-value: 1.04e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133889 3860 MI P FRL L YDYLTARY PD PVMYYAMK K QLLH S L A VL S TIE Y HCNLTPMGP D QMMMTMN TG V L snpsyr F E I RG G RS L H D IQ 3939
Cdd:pfam00454 103 LP P KVG L LQWFVKKS PD AEEWGEAR K NFVR S C A GY S VLD Y ILGNGDRHL D NILVDKT TG K L ------ F H I DF G LC L P D AG 176
90 100
....*....|....*....|....*.
gi 1799133889 3940 HFGH --- E VPFRLT PNLSILV G VAQ D 3962
Cdd:pfam00454 177 KDLP fpe K VPFRLT REMVYAM G PSG D 202
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
