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Conserved domains on  [gi|1799133590|ref|NP_001364750|]
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F-box domain-containing protein [Caenorhabditis elegans]

Protein Classification

F-box protein( domain architecture ID 10459153)

F-box protein is the substrate-recognition component of a SCF(Skp1-cullin-F-box) E3 ubiquitin ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins

CATH:  1.20.1280.50
Gene Ontology:  GO:0019005|GO:0005515|GO:0006511
PubMed:  11178263|31898225
SCOP:  4001927

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FBA_2 pfam07735
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ...
 190-256 2.55e-10

F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.


:

Pssm-ID: 429626  Cd Length: 67  Bit Score: 55.65  E-value: 2.55e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1799133590 190 RKMLIQNFGLVFYVSvgSGRHFTLNDLLVMNTCHLHLTDSKLSSEDLNIFIKSMINTPDQLLEDVQF 256
Cdd:pfam07735   3 QKILIQNLDELTIGD--SSVWITLDDLLLINSKKIELDNSRLSLKDLNRFLKHWIKGSNPRLEYLEI 67
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 7-48 1.70e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


:

Pssm-ID: 425796  Cd Length: 43  Bit Score: 38.29  E-value: 1.70e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1799133590   7 ILRLPSKTIQDVIQNMPLCNLLSFSLCSRAAKSRVTQLKLNV 48
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWK 42
 
Name Accession Description Interval E-value
FBA_2 pfam07735
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ...
 190-256 2.55e-10

F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.


Pssm-ID: 429626  Cd Length: 67  Bit Score: 55.65  E-value: 2.55e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1799133590 190 RKMLIQNFGLVFYVSvgSGRHFTLNDLLVMNTCHLHLTDSKLSSEDLNIFIKSMINTPDQLLEDVQF 256
Cdd:pfam07735   3 QKILIQNLDELTIGD--SSVWITLDDLLLINSKKIELDNSRLSLKDLNRFLKHWIKGSNPRLEYLEI 67
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 7-48 1.70e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 38.29  E-value: 1.70e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1799133590   7 ILRLPSKTIQDVIQNMPLCNLLSFSLCSRAAKSRVTQLKLNV 48
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWK 42
 
Name Accession Description Interval E-value
FBA_2 pfam07735
F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that ...
 190-256 2.55e-10

F-box associated; Most of these proteins contain pfam00646 at the N terminus, suggesting that they are effectors linked with ubiquitination.


Pssm-ID: 429626  Cd Length: 67  Bit Score: 55.65  E-value: 2.55e-10
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1799133590 190 RKMLIQNFGLVFYVSvgSGRHFTLNDLLVMNTCHLHLTDSKLSSEDLNIFIKSMINTPDQLLEDVQF 256
Cdd:pfam07735   3 QKILIQNLDELTIGD--SSVWITLDDLLLINSKKIELDNSRLSLKDLNRFLKHWIKGSNPRLEYLEI 67
F-box pfam00646
F-box domain; This domain is approximately 50 amino acids long, and is usually found in the ...
 7-48 1.70e-04

F-box domain; This domain is approximately 50 amino acids long, and is usually found in the N-terminal half of a variety of proteins. Two motifs that are commonly found associated with the F-box domain are the leucine rich repeats (LRRs; pfam00560 and pfam07723) and the WD repeat (pfam00400). The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.


Pssm-ID: 425796  Cd Length: 43  Bit Score: 38.29  E-value: 1.70e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 1799133590   7 ILRLPSKTIQDVIQNMPLCNLLSFSLCSRAAKSRVTQLKLNV 48
Cdd:pfam00646   1 LLDLPDDLLLEILSRLDPKDLLRLSLVSKRWRSLVDSLKLWK 42
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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