FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133564 444 YIECFEEFvLPLDRLFSVEKFTVNLRNPEIVGQLLTYMDPVSLRKIEFGSEYVNRPWKQIeldnkinlCNMEHWKNAKEL 523
Cdd:pfam01827   3 IIESFLNI-LKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIELSSESDEDQFEEI--------VELEQWKNAKSL 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133564 524 TINNTVVKC-DVEVLIHFSEVDIILDSMLLQNVVYLKDTFLSSPTFCQFKAQFVNSDINE 582
Cdd:pfam01827  74 KIEGSSLSSfPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDLNPIE 133

F-box domain superfamily; This short domain is commonly found at the N-terminus of various proteins, and typically co-occurs with one or more other conserved domains or motifs, such as leucine rich repeats, WD40 repeats, kelch, tub, spry, and others. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression. One of the best researched roles of F-box proteins is their participation in SCF (Skp1-Cul1-F-box protein), a multi-protein complex that functions as a ubiquitin E3 ligase, where the role of the F-box protein is to recruit target substrates. Gene families containing the F-box are found greatly expanded in narrow taxonomic lineages, such as flowering plants and nematodes. In this hierarchical classification, many of the subfamilies are named according to their domain architectures.

                          10        20        30
                  ....*....|....*....|....*....|...
gi 1799133564 330 IMGKVTQYLDYKHLQVLRKVSRAIRQCIDILKP 362
Cdd:cd22150     8 ILNKILDKLDPIDRLVLRKVSRNLRDIVDNQDP 40

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133564 444 YIECFEEFvLPLDRLFSVEKFTVNLRNPEIVGQLLTYMDPVSLRKIEFGSEYVNRPWKQIeldnkinlCNMEHWKNAKEL 523
Cdd:pfam01827   3 IIESFLNI-LKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIELSSESDEDQFEEI--------VELEQWKNAKSL 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133564 524 TINNTVVKC-DVEVLIHFSEVDIILDSMLLQNVVYLKDTFLSSPTFCQFKAQFVNSDINE 582
Cdd:pfam01827  74 KIEGSSLSSfPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDLNPIE 133

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|...
gi 1799133564 330 IMGKVTQYLDYKHLQVLRKVSRAIRQCIDILKP 362
Cdd:cd22150     8 ILNKILDKLDPIDRLVLRKVSRNLRDIVDNQDP 40

FTH domain; This presumed domain is likely to be a protein-protein interaction module. It is found in many proteins from C. elegans. The domain is found associated with the F-box pfam00646. This domain is named FTH after FOG-2 homology domain.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133564 444 YIECFEEFvLPLDRLFSVEKFTVNLRNPEIVGQLLTYMDPVSLRKIEFGSEYVNRPWKQIeldnkinlCNMEHWKNAKEL 523
Cdd:pfam01827   3 IIESFLNI-LKSKKCLHVKEISLSGLSFSEVASILPYFDAGTLEEIELSSESDEDQFEEI--------VELEQWKNAKSL 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133564 524 TINNTVVKC-DVEVLIHFSEVDIILDSMLLQNVVYLKDTFLSSPTFCQFKAQFVNSDINE 582
Cdd:pfam01827  74 KIEGSSLSSfPIEHLFHFEEFDIKLDSFSVEDAIKIRDILLKSSTFQSCTIRSPDLNPIE 133

F-box domain found in Caenorhabditis elegans F-box domain-containing proteins (CeFBXA) and similar proteins; The family includes a group of uncharacterized Caenorhabditis elegans F-box domain-containing proteins. They may be components of SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. The F-box domain has a role in mediating protein-protein interactions in a variety of contexts, such as polyubiquitination, transcription elongation, centromere binding and translational repression.

                          10        20        30
                  ....*....|....*....|....*....|...
gi 1799133564 330 IMGKVTQYLDYKHLQVLRKVSRAIRQCIDILKP 362
Cdd:cd22150     8 ILNKILDKLDPIDRLVLRKVSRNLRDIVDNQDP 40