NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1799133602|ref|NP_001364795|]
View 

G-protein coupled receptors family 1 profile domain-containing protein [Caenorhabditis elegans]

Protein Classification

Srw family chemoreceptor( domain architecture ID 10563412)

Srw family chemoreceptor belongs to the G-protein coupled receptor (GPCR) superfamily and plays a role in chemoreception

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
7TM_GPCR_Srw pfam10324
Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis ...
23-328 4.38e-88

Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srw is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srw do not appear to be under as strong an adaptive evolutionary pressure as those of Srz.


:

Pssm-ID: 402097  Cd Length: 318  Bit Score: 267.53  E-value: 4.38e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133602  23 VQNYASTAGVIMNIPHIFILTRSSMRTSSTNSLMIGIAICDILYLSILAELWI--RNAYFSDFLCINVGSYAYIVSAWIL 100
Cdd:pfam10324   2 VEFILSFIGFIINIFHLIILTRKSMRTSSINIIMIGIAICDIITMLLTIYNFIpeFIISYENSECIPPDSYLKVLLDWIL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133602 101 ECLRDLIEKASFWLGFMLAMTRYIIMK--SSGRADKLARPSSGYLITFIISVISAALSGWYYGRYYLEKDQNLWIMWDEC 178
Cdd:pfam10324  82 ESLQDYSRRCSTWLGVFMALIRTLVVKnpMSNKIQKLSKPKFGLIIIIIVFILSLPISIFYYFRYEIVEVGGIWKPPPNC 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133602 179 AGYRPKVKGIRYFLVMDDA-----AIHSRSHTIINAISRTLI-SFLYPIIGVLLMVEIRRSAKFAAKKLKSEKSatERYH 252
Cdd:pfam10324 162 AGFPPNYTETRYVLVVSELftandGLLLKIFLLIDGIFSKIIpCILLPILTILLIIELRKAKKSRKNLSSSSKN--KSDR 239
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1799133602 253 ASRMILVMTVMYFLASAPIGALDFINVseIVTESSFLRLSLDHSAYLMSAIFCLNSASHCIINLSMSSAYRNTIKM 328
Cdd:pfam10324 240 TTKLVIFMTISFFIAEFPLGISYIIQF--FFTDNPGIRRILTYLSVIFSLLFTINSISHCFICFLMSSQYRKTAKK 313
 
Name Accession Description Interval E-value
7TM_GPCR_Srw pfam10324
Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis ...
23-328 4.38e-88

Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srw is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srw do not appear to be under as strong an adaptive evolutionary pressure as those of Srz.


Pssm-ID: 402097  Cd Length: 318  Bit Score: 267.53  E-value: 4.38e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133602  23 VQNYASTAGVIMNIPHIFILTRSSMRTSSTNSLMIGIAICDILYLSILAELWI--RNAYFSDFLCINVGSYAYIVSAWIL 100
Cdd:pfam10324   2 VEFILSFIGFIINIFHLIILTRKSMRTSSINIIMIGIAICDIITMLLTIYNFIpeFIISYENSECIPPDSYLKVLLDWIL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133602 101 ECLRDLIEKASFWLGFMLAMTRYIIMK--SSGRADKLARPSSGYLITFIISVISAALSGWYYGRYYLEKDQNLWIMWDEC 178
Cdd:pfam10324  82 ESLQDYSRRCSTWLGVFMALIRTLVVKnpMSNKIQKLSKPKFGLIIIIIVFILSLPISIFYYFRYEIVEVGGIWKPPPNC 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133602 179 AGYRPKVKGIRYFLVMDDA-----AIHSRSHTIINAISRTLI-SFLYPIIGVLLMVEIRRSAKFAAKKLKSEKSatERYH 252
Cdd:pfam10324 162 AGFPPNYTETRYVLVVSELftandGLLLKIFLLIDGIFSKIIpCILLPILTILLIIELRKAKKSRKNLSSSSKN--KSDR 239
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1799133602 253 ASRMILVMTVMYFLASAPIGALDFINVseIVTESSFLRLSLDHSAYLMSAIFCLNSASHCIINLSMSSAYRNTIKM 328
Cdd:pfam10324 240 TTKLVIFMTISFFIAEFPLGISYIIQF--FFTDNPGIRRILTYLSVIFSLLFTINSISHCFICFLMSSQYRKTAKK 313
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
31-326 6.08e-22

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 94.24  E-value: 6.08e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133602  31 GVIMNIPHIFILTRSSMRTsSTNSLMIGIAICDILYLSILAELWIRNAYFSDFLCINVGSYAYIvsAWILECLRDLIEKA 110
Cdd:cd14978    14 GIIGNILNLVVLTRKSMRS-STNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYF--LPYIYPLANTFQTA 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133602 111 SFWLGFMLAMTRYIIMKSSGRADKLARPSSGYLITFIISVISAALSGWYYGRYYLEKDQNLWIMWDECAGYRPKVKGIRY 190
Cdd:cd14978    91 SVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPTLLRQNETY 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133602 191 FLVmddaaihsrSHTIINAISRTLI-SFLYPIIGVLLMVEIRRSAKFAAKKLKSEKSATERYH----ASRMILVMTVMYF 265
Cdd:cd14978   171 LLK---------YYFWLYAIFVVLLpFILLLILNILLIRALRKSKKRRRLLRRRRRLLSRSQRrerrTTIMLIAVVIVFL 241
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1799133602 266 LASAPIGaldFINVSEIVTESSFLRLSLDHSAYLMSAIFCLNSASHCIINLSMSSAYRNTI 326
Cdd:cd14978   242 ICNLPAG---ILNILEAIFGESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
 
Name Accession Description Interval E-value
7TM_GPCR_Srw pfam10324
Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis ...
23-328 4.38e-88

Serpentine type 7TM GPCR chemoreceptor Srw; Chemoreception is mediated in Caenorhabditis elegans by members of the seven-transmembrane G-protein-coupled receptor class (7TM GPCRs) of proteins which are of the serpentine type. Srw is a solo family amongst the superfamilies of chemoreceptors. Chemoperception is one of the central senses of soil nematodes like C. elegans which are otherwise 'blind' and 'deaf'. The genes encoding Srw do not appear to be under as strong an adaptive evolutionary pressure as those of Srz.


Pssm-ID: 402097  Cd Length: 318  Bit Score: 267.53  E-value: 4.38e-88
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133602  23 VQNYASTAGVIMNIPHIFILTRSSMRTSSTNSLMIGIAICDILYLSILAELWI--RNAYFSDFLCINVGSYAYIVSAWIL 100
Cdd:pfam10324   2 VEFILSFIGFIINIFHLIILTRKSMRTSSINIIMIGIAICDIITMLLTIYNFIpeFIISYENSECIPPDSYLKVLLDWIL 81
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133602 101 ECLRDLIEKASFWLGFMLAMTRYIIMK--SSGRADKLARPSSGYLITFIISVISAALSGWYYGRYYLEKDQNLWIMWDEC 178
Cdd:pfam10324  82 ESLQDYSRRCSTWLGVFMALIRTLVVKnpMSNKIQKLSKPKFGLIIIIIVFILSLPISIFYYFRYEIVEVGGIWKPPPNC 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133602 179 AGYRPKVKGIRYFLVMDDA-----AIHSRSHTIINAISRTLI-SFLYPIIGVLLMVEIRRSAKFAAKKLKSEKSatERYH 252
Cdd:pfam10324 162 AGFPPNYTETRYVLVVSELftandGLLLKIFLLIDGIFSKIIpCILLPILTILLIIELRKAKKSRKNLSSSSKN--KSDR 239
                         250       260       270       280       290       300       310
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 1799133602 253 ASRMILVMTVMYFLASAPIGALDFINVseIVTESSFLRLSLDHSAYLMSAIFCLNSASHCIINLSMSSAYRNTIKM 328
Cdd:pfam10324 240 TTKLVIFMTISFFIAEFPLGISYIIQF--FFTDNPGIRRILTYLSVIFSLLFTINSISHCFICFLMSSQYRKTAKK 313
7tmA_FMRFamide_R-like cd14978
FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of ...
31-326 6.08e-22

FMRFamide (Phe-Met-Arg-Phe) receptors and related proteins, member of the class A family of seven-transmembrane G protein-coupled receptors; This group includes Drosophila melanogaster G-protein coupled FMRFamide (Phe-Met-Arg-Phe-NH2) receptor DrmFMRFa-R and related invertebrate receptors, as well as the vertebrate proteins GPR139 and GPR142. DrmFMRFa-R binds with high affinity to FMRFamide and intrinsic FMRFamide-related peptides. FMRFamide is a neuropeptide from the family of FMRFamide-related peptides (FaRPs), which all containing a C-terminal RFamide (Arg-Phe-NH2) motif and have diverse functions in the central and peripheral nervous systems. FMRFamide is an important neuropeptide in many types of invertebrates such as insects, nematodes, molluscs, and worms. In invertebrates, the FMRFamide-related peptides are involved in the regulation of heart rate, blood pressure, gut motility, feeding behavior, and reproduction. On the other hand, in vertebrates such as mice, they play a role in the modulation of morphine-induced antinociception. Orphan receptors GPR139 and GPR142 are very closely related G protein-coupled receptors, but they have different expression patterns in the brain and in other tissues. These receptors couple to inhibitory G proteins and activate phospholipase C. Studies suggested that dimer formation may be required for their proper function. GPR142 is predominantly expressed in pancreatic beta-cells and mediates enhancement of glucose-stimulated insulin secretion, whereas GPR139 is mostly expressed in the brain and is suggested to play a role in the control of locomotor activity. Tryptophan and phenylalanine have been identified as putative endogenous ligands of GPR139.


Pssm-ID: 410630 [Multi-domain]  Cd Length: 299  Bit Score: 94.24  E-value: 6.08e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133602  31 GVIMNIPHIFILTRSSMRTsSTNSLMIGIAICDILYLSILAELWIRNAYFSDFLCINVGSYAYIvsAWILECLRDLIEKA 110
Cdd:cd14978    14 GIIGNILNLVVLTRKSMRS-STNVYLAALAVSDILVLLSALPLFLLPYIADYSSSFLSYFYAYF--LPYIYPLANTFQTA 90
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133602 111 SFWLGFMLAMTRYIIMKSSGRADKLARPSSGYLITFIISVISAALSGWYYGRYYLEKDQNLWIMWDECAGYRPKVKGIRY 190
Cdd:cd14978    91 SVWLTVALTVERYIAVCHPLKARTWCTPRRARRVILIIIIFSLLLNLPRFFEYEVVECENCNNNSYYYVIPTLLRQNETY 170
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133602 191 FLVmddaaihsrSHTIINAISRTLI-SFLYPIIGVLLMVEIRRSAKFAAKKLKSEKSATERYH----ASRMILVMTVMYF 265
Cdd:cd14978   171 LLK---------YYFWLYAIFVVLLpFILLLILNILLIRALRKSKKRRRLLRRRRRLLSRSQRrerrTTIMLIAVVIVFL 241
                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1799133602 266 LASAPIGaldFINVSEIVTESSFLRLSLDHSAYLMSAIFCLNSASHCIINLSMSSAYRNTI 326
Cdd:cd14978   242 ICNLPAG---ILNILEAIFGESFLSPIYQLLGDISNLLVVLNSAVNFIIYCLFSSKFRRTF 299
7tmA_Opsins_type2_animals cd14969
type 2 opsins in animals, member of the class A family of seven-transmembrane G ...
29-270 7.89e-07

type 2 opsins in animals, member of the class A family of seven-transmembrane G protein-coupled receptors; This rhodopsin family represents the type 2 opsins found in vertebrates and invertebrates except sponge. Type 2 opsins primarily function as G protein coupled receptors and are responsible for vision as well as for circadian rhythm and pigment regulation. On the contrary, type 1 opsins such as bacteriorhodopsin and proteorhodopsin are found in both prokaryotic and eukaryotic microbes, functioning as light-gated ion channels, proton pumps, sensory receptors and in other unknown functions. Although these two opsin types share seven-transmembrane domain topology and a conserved lysine reside in the seventh helix, type 1 opsins do not activate G-proteins and are not evolutionarily related to type 2. Type 2 opsins can be classified into six distinct subfamilies including the vertebrate opsins/encephalopsins, the G(o) opsins, the G(s) opsins, the invertebrate G(q) opsins, the photoisomerases, and the neuropsins.


Pssm-ID: 381741 [Multi-domain]  Cd Length: 284  Bit Score: 49.90  E-value: 7.89e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133602  29 TAGVIMNIPHIFILTRSSMRTSSTNSLMIGIAICDILyLSILAELW------IRNAYFSDFLCInvgSYAYIVSAWILec 102
Cdd:cd14969    12 VLGVVLNGLVIIVFLKKKKLRTPLNLFLLNLALADLL-MSVVGYPLsfysnlSGRWSFGDPGCV---IYGFAVTFLGL-- 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133602 103 lrdliekASFWLGFMLAMTRYIIMKSSGRADKLARPSSGYLITFI----ISVISAALSGWyyGRYYLEKDqnlwimwdec 178
Cdd:cd14969    86 -------VSISTLAALAFERYLVIVRPLKAFRLSKRRALILIAFIwlygLFWALPPLFGW--SSYVPEGG---------- 146
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133602 179 agyrpkvkGIRYFLVMDDAAIHSRSHTII-----NAISRTLISFLYpiigVLLMVEIRRSAKFAAKKLKSEKSA----TE 249
Cdd:cd14969   147 --------GTSCSVDWYSKDPNSLSYIVSlfvfcFFLPLAIIIFCY----YKIYRTLRKMSKRAARRKNSAITKrtkkAE 214
                         250       260
                  ....*....|....*....|.
gi 1799133602 250 RYHAsRMILVMTVMYFLASAP 270
Cdd:cd14969   215 KKVA-KMVLVMIVAFLIAWTP 234
7tm_classA_rhodopsin-like cd00637
rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor ...
39-314 6.30e-03

rhodopsin receptor-like class A family of the seven-transmembrane G protein-coupled receptor superfamily; Class A rhodopsin-like receptors constitute about 90% of all GPCRs. The class A GPCRs include the light-sensitive rhodopsin as well as receptors for biogenic amines, lipids, nucleotides, odorants, peptide hormones, and a variety of other ligands. All GPCRs have a common structural architecture comprising of seven-transmembrane (TM) alpha-helices interconnected by three extracellular and three intracellular loops. A general feature of GPCR signaling is agonist-induced conformational changes in the receptors, leading to activation of the heterotrimeric G proteins, which consist of the guanine nucleotide-binding G-alpha subunit and the dimeric G-beta-gamma subunits. The activated G proteins then bind to and activate numerous downstream effector proteins, which generate second messengers that mediate a broad range of cellular and physiological processes. Based on sequence similarity, GPCRs can be divided into six major classes: class A (rhodopsin-like family), class B (Methuselah-like, adhesion and secretin-like receptor family), class C (metabotropic glutamate receptor family), class D (fungal mating pheromone receptors), class E (cAMP receptor family), and class F (frizzled/smoothened receptor family). Nearly 800 human GPCR genes have been identified and are involved essentially in all major physiological processes. Approximately 40% of clinically marketed drugs mediate their effects through modulation of GPCR function for the treatment of a variety of human diseases including bacterial infections.


Pssm-ID: 410626 [Multi-domain]  Cd Length: 275  Bit Score: 38.04  E-value: 6.30e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133602  39 IFILTRSSMRTSsTNSLMIGIAICDILYLSI-----LAELWIRNAYFSDFLCInvgSYAYIVSAWILeclrdliekASFW 113
Cdd:cd00637    21 LVILRNRRLRTV-TNYFILNLAVADLLVGLLvipfsLVSLLLGRWWFGDALCK---LLGFLQSVSLL---------ASIL 87
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133602 114 LGFMLAMTRYI-IMKSSGRADKLARPSSGYLITFI--ISVISAALSGWYYGRYYLEKDQNLWIMWDECAGYRPkvkgirY 190
Cdd:cd00637    88 TLTAISVDRYLaIVHPLRYRRRFTRRRAKLLIALIwlLSLLLALPPLLGWGVYDYGGYCCCCLCWPDLTLSKA------Y 161
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1799133602 191 FLVMddaaihsrsHTIINAISRTLISFLYPIIGVLLMVEIRRSAKFAAKKLKSEKSATERyHASRMILVMTVMYFLASAP 270
Cdd:cd00637   162 TIFL---------FVLLFLLPLLVIIVCYVRIFRKLRRHRRRIRSSSSNSSRRRRRRRER-KVTKTLLIVVVVFLLCWLP 231
                         250       260       270       280
                  ....*....|....*....|....*....|....*....|....*..
gi 1799133602 271 IGALDFINVseivtessFLRLSLDHSAYLMSAIFCL---NSASHCII 314
Cdd:cd00637   232 YFILLLLDV--------FGPDPSPLPRILYFLALLLaylNSAINPII 270
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH