traB domain-containing protein isoform c [Homo sapiens]
Protein Classification
TraB domain-containing protein( domain architecture ID 12999407)
TraB domain-containing protein
List of domain hits
| Name | Accession | Description | Interval | E-value | ||||
| TraB_PrgY-like | cd14726 | TraB/PryY confer plasmid-borne pheromone resistance; TraB/PrgY proteins, identified in gut ... |
75-273 | 1.60e-57 | ||||
TraB/PryY confer plasmid-borne pheromone resistance; TraB/PrgY proteins, identified in gut bacterium Enterococcus faecalis, are plasmid-borne homologs that are induced by pheromones. Induction rends the host bacterium insensitive to self-induction by its own pheromones, and prevents the transfer of the pheromone-inducible conjugative plasmids to bacteria that already contain it. Based on homology to Tiki activity, it has been proposed that TraB acts as a protease in the inactivation of mating pheromone, cleaving at the amino-terminus. The pheromones are small peptides (7-8 residues) encoded by the bacterial genome, and are specific for particular plasmids, or class of plasmids, which may contain several virulence factors and disseminate rapidly. Plasmid-borne antibiotic resistance and virulence determinants make these elements important contributors to medical problems. Trab/PrygY is a member of a Tiki-like superfamily. Tiki is a membrane-associated metalloprotease (MEROPS family M96) that inhibits Wnt via the cleavage of its amino terminus. Wnt is essential in animal development and homeostasis. In Xenopus, Tiki is critical in head development. In human cells, Tiki inhibits Wnt-signaling. Tiki proteins are also related to erythromycin esterase, gumN plant pathogens, RtxA containing toxins, and Campylobacter Jejuni ChaN heme-binding protein. : Pssm-ID: 350608 Cd Length: 177 Bit Score: 185.47 E-value: 1.60e-57
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| Name | Accession | Description | Interval | E-value | |||||
| TraB_PrgY-like | cd14726 | TraB/PryY confer plasmid-borne pheromone resistance; TraB/PrgY proteins, identified in gut ... |
75-273 | 1.60e-57 | |||||
TraB/PryY confer plasmid-borne pheromone resistance; TraB/PrgY proteins, identified in gut bacterium Enterococcus faecalis, are plasmid-borne homologs that are induced by pheromones. Induction rends the host bacterium insensitive to self-induction by its own pheromones, and prevents the transfer of the pheromone-inducible conjugative plasmids to bacteria that already contain it. Based on homology to Tiki activity, it has been proposed that TraB acts as a protease in the inactivation of mating pheromone, cleaving at the amino-terminus. The pheromones are small peptides (7-8 residues) encoded by the bacterial genome, and are specific for particular plasmids, or class of plasmids, which may contain several virulence factors and disseminate rapidly. Plasmid-borne antibiotic resistance and virulence determinants make these elements important contributors to medical problems. Trab/PrygY is a member of a Tiki-like superfamily. Tiki is a membrane-associated metalloprotease (MEROPS family M96) that inhibits Wnt via the cleavage of its amino terminus. Wnt is essential in animal development and homeostasis. In Xenopus, Tiki is critical in head development. In human cells, Tiki inhibits Wnt-signaling. Tiki proteins are also related to erythromycin esterase, gumN plant pathogens, RtxA containing toxins, and Campylobacter Jejuni ChaN heme-binding protein. Pssm-ID: 350608 Cd Length: 177 Bit Score: 185.47 E-value: 1.60e-57
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| COG1916 | COG1916 | Pheromone shutdown protein TraB, contains GTxH motif (function unknown) [Function unknown]; |
58-347 | 6.25e-48 | |||||
Pheromone shutdown protein TraB, contains GTxH motif (function unknown) [Function unknown]; Pssm-ID: 441520 Cd Length: 392 Bit Score: 166.90 E-value: 6.25e-48
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| traB | TIGR00261 | pheromone shutdown-related protein TraB; traB is a plasmid encoded gene that functions in the ... |
74-273 | 1.42e-27 | |||||
pheromone shutdown-related protein TraB; traB is a plasmid encoded gene that functions in the shutdown of the peptide sex pheromone cPD1 which is produced by the plasmid free recipient cell prior to conjugative transfer in Enterococcus faecalis. Once the recipient acquires the plasmid, production of cPD1 is shut down. The gene product may play another role in the other species in the family. [Unknown function, General] Pssm-ID: 129363 Cd Length: 380 Bit Score: 111.87 E-value: 1.42e-27
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| TraB_PrgY_gumN | pfam01963 | TraB/PrgY/gumN family; This entry includes Tiki1/2 from humans, TraB/PrgY from the gut flora ... |
68-275 | 8.25e-17 | |||||
TraB/PrgY/gumN family; This entry includes Tiki1/2 from humans, TraB/PrgY from the gut flora Enterococcusfaecalis and gumN from the plant pathogen Xanthomonas. Tiki1 is homologous to TraB/PrgY. They have a pair of widely spaced GX2H motifs and a conserved glutamate. From the structural study, this group of proteins have been identified as an ancient metalloprotease clan with a common protein architecture (cobbled from the folds of the EreA/ChaN/PMT group) that mediates proteolytic activities. Tiki1 is a membrane-associated protease that inhibits Wnt via the cleavage of its amino terminus, diminishing Wnt's binding to receptors. TraB/PrgY is an inhibitor peptide that may act as a protease to inactivate the mating pheromone. Pssm-ID: 426534 Cd Length: 262 Bit Score: 79.32 E-value: 8.25e-17
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| Name | Accession | Description | Interval | E-value | |||||
| TraB_PrgY-like | cd14726 | TraB/PryY confer plasmid-borne pheromone resistance; TraB/PrgY proteins, identified in gut ... |
75-273 | 1.60e-57 | |||||
TraB/PryY confer plasmid-borne pheromone resistance; TraB/PrgY proteins, identified in gut bacterium Enterococcus faecalis, are plasmid-borne homologs that are induced by pheromones. Induction rends the host bacterium insensitive to self-induction by its own pheromones, and prevents the transfer of the pheromone-inducible conjugative plasmids to bacteria that already contain it. Based on homology to Tiki activity, it has been proposed that TraB acts as a protease in the inactivation of mating pheromone, cleaving at the amino-terminus. The pheromones are small peptides (7-8 residues) encoded by the bacterial genome, and are specific for particular plasmids, or class of plasmids, which may contain several virulence factors and disseminate rapidly. Plasmid-borne antibiotic resistance and virulence determinants make these elements important contributors to medical problems. Trab/PrygY is a member of a Tiki-like superfamily. Tiki is a membrane-associated metalloprotease (MEROPS family M96) that inhibits Wnt via the cleavage of its amino terminus. Wnt is essential in animal development and homeostasis. In Xenopus, Tiki is critical in head development. In human cells, Tiki inhibits Wnt-signaling. Tiki proteins are also related to erythromycin esterase, gumN plant pathogens, RtxA containing toxins, and Campylobacter Jejuni ChaN heme-binding protein. Pssm-ID: 350608 Cd Length: 177 Bit Score: 185.47 E-value: 1.60e-57
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| COG1916 | COG1916 | Pheromone shutdown protein TraB, contains GTxH motif (function unknown) [Function unknown]; |
58-347 | 6.25e-48 | |||||
Pheromone shutdown protein TraB, contains GTxH motif (function unknown) [Function unknown]; Pssm-ID: 441520 Cd Length: 392 Bit Score: 166.90 E-value: 6.25e-48
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| traB | TIGR00261 | pheromone shutdown-related protein TraB; traB is a plasmid encoded gene that functions in the ... |
74-273 | 1.42e-27 | |||||
pheromone shutdown-related protein TraB; traB is a plasmid encoded gene that functions in the shutdown of the peptide sex pheromone cPD1 which is produced by the plasmid free recipient cell prior to conjugative transfer in Enterococcus faecalis. Once the recipient acquires the plasmid, production of cPD1 is shut down. The gene product may play another role in the other species in the family. [Unknown function, General] Pssm-ID: 129363 Cd Length: 380 Bit Score: 111.87 E-value: 1.42e-27
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| TraB_PrgY_gumN | pfam01963 | TraB/PrgY/gumN family; This entry includes Tiki1/2 from humans, TraB/PrgY from the gut flora ... |
68-275 | 8.25e-17 | |||||
TraB/PrgY/gumN family; This entry includes Tiki1/2 from humans, TraB/PrgY from the gut flora Enterococcusfaecalis and gumN from the plant pathogen Xanthomonas. Tiki1 is homologous to TraB/PrgY. They have a pair of widely spaced GX2H motifs and a conserved glutamate. From the structural study, this group of proteins have been identified as an ancient metalloprotease clan with a common protein architecture (cobbled from the folds of the EreA/ChaN/PMT group) that mediates proteolytic activities. Tiki1 is a membrane-associated protease that inhibits Wnt via the cleavage of its amino terminus, diminishing Wnt's binding to receptors. TraB/PrgY is an inhibitor peptide that may act as a protease to inactivate the mating pheromone. Pssm-ID: 426534 Cd Length: 262 Bit Score: 79.32 E-value: 8.25e-17
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