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Conserved domains on  [gi|1821955815|ref|NP_001365926|]
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R3H domain-containing protein 4 isoform 1 [Mus musculus]

Protein Classification

R3H domain-containing protein( domain architecture ID 10621380)

R3H domain-containing protein

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
R3H-assoc pfam13902
R3H-associated N-terminal domain; This family is found at the N-terminus of R3H, pfam01424, ...
 43-177 5.30e-35

R3H-associated N-terminal domain; This family is found at the N-terminus of R3H, pfam01424, domain-containing proteins. The function is not known.


:

Pssm-ID: 464031  Cd Length: 127  Bit Score: 122.14  E-value: 5.30e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821955815  43 RKQHFINQAVRNSDLVPRAKGRKSLQRLENTQYLLTLLETagGPPGVEDGDLTPAAPGIFAEACSNATYVEVWNDFMNRS 122
Cdd:pfam13902   1 RKPIRRDSAKRREALLKGKEGSRRRRRWENDRLLHELVPR--LDEIEDDPDAEPPLPSDFTVLPTHPENAQLWDDFRNLD 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1821955815 123 GEEQERVLRYLEDESQgkrrrgPGRGEDRRREDPVFTPHECFRRISRRLRSVLKR 177
Cdd:pfam13902  79 EDEQERILASLEQSEK------KRKKHRVSGEDDRESALARFQRIDRRLRAALKR 127
R3H pfam01424
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ...
 189-248 4.10e-05

R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA.


:

Pssm-ID: 460206  Cd Length: 60  Bit Score: 40.55  E-value: 4.10e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821955815 189 ETLESWEERLLAFFSVSPQAVYTAMLdNSYERLLLHAVCQYMDLISASADLEGRRQMKVS 248
Cdd:pfam01424   1 EFLEQLAEKLAEFVKDTGKSLELPPM-SSYERRIIHELAQKYGLESESEGEEPNRRVVVY 59
 
Name Accession Description Interval E-value
R3H-assoc pfam13902
R3H-associated N-terminal domain; This family is found at the N-terminus of R3H, pfam01424, ...
 43-177 5.30e-35

R3H-associated N-terminal domain; This family is found at the N-terminus of R3H, pfam01424, domain-containing proteins. The function is not known.


Pssm-ID: 464031  Cd Length: 127  Bit Score: 122.14  E-value: 5.30e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821955815  43 RKQHFINQAVRNSDLVPRAKGRKSLQRLENTQYLLTLLETagGPPGVEDGDLTPAAPGIFAEACSNATYVEVWNDFMNRS 122
Cdd:pfam13902   1 RKPIRRDSAKRREALLKGKEGSRRRRRWENDRLLHELVPR--LDEIEDDPDAEPPLPSDFTVLPTHPENAQLWDDFRNLD 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1821955815 123 GEEQERVLRYLEDESQgkrrrgPGRGEDRRREDPVFTPHECFRRISRRLRSVLKR 177
Cdd:pfam13902  79 EDEQERILASLEQSEK------KRKKHRVSGEDDRESALARFQRIDRRLRAALKR 127
R3H pfam01424
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ...
 189-248 4.10e-05

R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA.


Pssm-ID: 460206  Cd Length: 60  Bit Score: 40.55  E-value: 4.10e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821955815 189 ETLESWEERLLAFFSVSPQAVYTAMLdNSYERLLLHAVCQYMDLISASADLEGRRQMKVS 248
Cdd:pfam01424   1 EFLEQLAEKLAEFVKDTGKSLELPPM-SSYERRIIHELAQKYGLESESEGEEPNRRVVVY 59
R3H cd02325
R3H domain. The name of the R3H domain comes from the characteristic spacing of the most ...
 216-248 1.28e-03

R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich repeats, ring-type zinc fingers, and KH domains. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100064  Cd Length: 59  Bit Score: 36.44  E-value: 1.28e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1821955815 216 NSYERLLLHAVCQYMDLISASADLEGRRQMKVS 248
Cdd:cd02325    26 NSYERKLIHDLAEYYGLKSESEGEGPNRRVVIT 58
R3H smart00393
Putative single-stranded nucleic acids-binding domain;
188-250 2.37e-03

Putative single-stranded nucleic acids-binding domain;


Pssm-ID: 214647  Cd Length: 79  Bit Score: 36.12  E-value: 2.37e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1821955815  188 QETLESWEERLLAFF-SVSPQAVYTAMldNSYERLLLHAVCQYMDLISASADLEGRRQMKVSNR 250
Cdd:smart00393  18 REELIELELEIARFVkSTKESVELPPM--NSYERKIVHELAEKYGLESESFGEGPKRRVVISKK 79
 
Name Accession Description Interval E-value
R3H-assoc pfam13902
R3H-associated N-terminal domain; This family is found at the N-terminus of R3H, pfam01424, ...
 43-177 5.30e-35

R3H-associated N-terminal domain; This family is found at the N-terminus of R3H, pfam01424, domain-containing proteins. The function is not known.


Pssm-ID: 464031  Cd Length: 127  Bit Score: 122.14  E-value: 5.30e-35
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821955815  43 RKQHFINQAVRNSDLVPRAKGRKSLQRLENTQYLLTLLETagGPPGVEDGDLTPAAPGIFAEACSNATYVEVWNDFMNRS 122
Cdd:pfam13902   1 RKPIRRDSAKRREALLKGKEGSRRRRRWENDRLLHELVPR--LDEIEDDPDAEPPLPSDFTVLPTHPENAQLWDDFRNLD 78

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 1821955815 123 GEEQERVLRYLEDESQgkrrrgPGRGEDRRREDPVFTPHECFRRISRRLRSVLKR 177
Cdd:pfam13902  79 EDEQERILASLEQSEK------KRKKHRVSGEDDRESALARFQRIDRRLRAALKR 127
R3H pfam01424
R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most ...
 189-248 4.10e-05

R3H domain; The name of the R3H domain comes from the characteriztic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to be binding ssDNA.


Pssm-ID: 460206  Cd Length: 60  Bit Score: 40.55  E-value: 4.10e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1821955815 189 ETLESWEERLLAFFSVSPQAVYTAMLdNSYERLLLHAVCQYMDLISASADLEGRRQMKVS 248
Cdd:pfam01424   1 EFLEQLAEKLAEFVKDTGKSLELPPM-SSYERRIIHELAQKYGLESESEGEEPNRRVVVY 59
R3H cd02325
R3H domain. The name of the R3H domain comes from the characteristic spacing of the most ...
 216-248 1.28e-03

R3H domain. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. R3H domains are found in proteins together with ATPase domains, SF1 helicase domains, SF2 DEAH helicase domains, Cys-rich repeats, ring-type zinc fingers, and KH domains. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100064  Cd Length: 59  Bit Score: 36.44  E-value: 1.28e-03
                          10        20        30
                  ....*....|....*....|....*....|...
gi 1821955815 216 NSYERLLLHAVCQYMDLISASADLEGRRQMKVS 248
Cdd:cd02325    26 NSYERKLIHDLAEYYGLKSESEGEGPNRRVVIT 58
R3H_encore_like cd02642
R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the ...
 195-243 1.47e-03

R3H domain of encore-like and DIP1-like proteins. Drosophila encore is involved in the germline exit after four mitotic divisions, by facilitating SCF-ubiquitin-proteasome-dependent proteolysis. Maize DBF1-interactor protein 1 (DIP1) containing an R3H domain is a potential regulator of DBF1 activity in stress responses. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine and histidine residues. The function of the domain is predicted to bind ssDNA or ssRNA in a sequence-specific manner.


Pssm-ID: 100071  Cd Length: 63  Bit Score: 36.04  E-value: 1.47e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*....
gi 1821955815 195 EERLLAFFSVSPQAVYTAMLDNSYERLLLHAVCQYMDLISASADLEGRR 243
Cdd:cd02642     9 EKDLLAFIKDSTRQSLELPPMNSYYRLLAHRVAQYYGLDHNVDNSGGKC 57
R3H smart00393
Putative single-stranded nucleic acids-binding domain;
188-250 2.37e-03

Putative single-stranded nucleic acids-binding domain;


Pssm-ID: 214647  Cd Length: 79  Bit Score: 36.12  E-value: 2.37e-03
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1821955815  188 QETLESWEERLLAFF-SVSPQAVYTAMldNSYERLLLHAVCQYMDLISASADLEGRRQMKVSNR 250
Cdd:smart00393  18 REELIELELEIARFVkSTKESVELPPM--NSYERKIVHELAEKYGLESESFGEGPKRRVVISKK 79
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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