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Conserved domains on  [gi|1831510207|ref|NP_001366876|]
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Putative potassium channel regulatory protein unc-93 [Caenorhabditis elegans]

Protein Classification

unc-93 family MFS transporter( domain architecture ID 13024466)

unc-93 family major facilitator superfamily (MFS) transporter similar to Caenorhabditis elegans Uncoordinated protein 93 that acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS_unc93A_like cd17406
Protein unc-93 homolog A and similar proteins of the Major Facilitator Superfamily of ...
 245-673 0e+00

Protein unc-93 homolog A and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Caenorhabditis elegans Uncoordinated protein 93 (also called putative potassium channel regulatory protein unc-93), human protein unc-93 homolog A (HmUnc-93A or UNC93A), and similar proteins. Unc-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. The human UNC93A gene is located in a region of the genome that is frequently associated with ovarian cancer, however, there is no evidence that UNC93A has a tumor suppressor function. This unc93A-like subfamily belongs to the Unc-93 family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


:

Pssm-ID: 340964 [Multi-domain]  Cd Length: 390  Bit Score: 551.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 245 LWILSVAFLFLFTAFNGLQNLQTSVN--GDLGSDSLVALYLSLAISSLFVPSFMINRLGCKLTFLIAIFVYFLYIVINLR 322
Cdd:cd17406     1 LLVISFAFLLLFTAFQGLQNLQSSLNsdDGLGVVSLSVIYASLIVSCMFLPPLLIKKLGCKWTIVLSMFCYVLYIAANFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 323 PTYSSMIPASIFCGIAASCIWGAKCAYITEMGIRYASLNFESQTTVIVRFFGYFFMIVHCGQVVGNMVSSYIFTlsysqa 402
Cdd:cd17406    81 PSWYTLIPASIILGFGAAPLWSAKCTYLTESGNRYAKLTGKSGDDVINRFFGIFFMIFQSSQIWGNLISSLVFS------ 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 403 lrgpedsiydscgyqfpknlsdltelaesnlarppQKVYVAVCLAYLACVIISGMIMSMFLNALAKDARNRKMAQKF-NS 481
Cdd:cd17406   155 -----------------------------------QSLIYTLLGIYLGCGILAVIIVAVFLDPLKRDKEKRKQETKFsVL 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 482 EIFYLMLKHLINIKFMLLVPLTIFNGLEQAFLVGVYTKAFVGCGLGIWQIGFVMACFGISDAVCSLVFGPLIKLFGRMPL 561
Cdd:cd17406   200 SLLLATFKHLKDPRQLLLIPLTIYSGLEQAFLSGDFTKSYVTCALGIWNVGYVMICFGVVNALCSFLFGRLVKYTGRIPL 279

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 562 FVFGAVVNLLMIVTLMVWPLNAADTQIFYVVAAMWGMADGVWNTQINGFWVALVgRQSLQFAFTKYRFWESLGIAIGFAL 641
Cdd:cd17406   280 FALGALVNLGLIIALLLWEPDPDQLAIFFVFAGLWGMADAVWQTQINALYGVLF-PKNKEAAFSNYRLWESLGFVIAFAY 358

                         410       420       430
                  ....*....|....*....|....*....|..
gi 1831510207 642 IRHVTVEIYLLITFFMLLLGMCGFLAIENFDH 673
Cdd:cd17406   359 SNFLCVYVKLYILLAVLLLGMVGYGVVEYIER 390
 
Name Accession Description Interval E-value
MFS_unc93A_like cd17406
Protein unc-93 homolog A and similar proteins of the Major Facilitator Superfamily of ...
 245-673 0e+00

Protein unc-93 homolog A and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Caenorhabditis elegans Uncoordinated protein 93 (also called putative potassium channel regulatory protein unc-93), human protein unc-93 homolog A (HmUnc-93A or UNC93A), and similar proteins. Unc-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. The human UNC93A gene is located in a region of the genome that is frequently associated with ovarian cancer, however, there is no evidence that UNC93A has a tumor suppressor function. This unc93A-like subfamily belongs to the Unc-93 family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340964 [Multi-domain]  Cd Length: 390  Bit Score: 551.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 245 LWILSVAFLFLFTAFNGLQNLQTSVN--GDLGSDSLVALYLSLAISSLFVPSFMINRLGCKLTFLIAIFVYFLYIVINLR 322
Cdd:cd17406     1 LLVISFAFLLLFTAFQGLQNLQSSLNsdDGLGVVSLSVIYASLIVSCMFLPPLLIKKLGCKWTIVLSMFCYVLYIAANFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 323 PTYSSMIPASIFCGIAASCIWGAKCAYITEMGIRYASLNFESQTTVIVRFFGYFFMIVHCGQVVGNMVSSYIFTlsysqa 402
Cdd:cd17406    81 PSWYTLIPASIILGFGAAPLWSAKCTYLTESGNRYAKLTGKSGDDVINRFFGIFFMIFQSSQIWGNLISSLVFS------ 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 403 lrgpedsiydscgyqfpknlsdltelaesnlarppQKVYVAVCLAYLACVIISGMIMSMFLNALAKDARNRKMAQKF-NS 481
Cdd:cd17406   155 -----------------------------------QSLIYTLLGIYLGCGILAVIIVAVFLDPLKRDKEKRKQETKFsVL 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 482 EIFYLMLKHLINIKFMLLVPLTIFNGLEQAFLVGVYTKAFVGCGLGIWQIGFVMACFGISDAVCSLVFGPLIKLFGRMPL 561
Cdd:cd17406   200 SLLLATFKHLKDPRQLLLIPLTIYSGLEQAFLSGDFTKSYVTCALGIWNVGYVMICFGVVNALCSFLFGRLVKYTGRIPL 279

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 562 FVFGAVVNLLMIVTLMVWPLNAADTQIFYVVAAMWGMADGVWNTQINGFWVALVgRQSLQFAFTKYRFWESLGIAIGFAL 641
Cdd:cd17406   280 FALGALVNLGLIIALLLWEPDPDQLAIFFVFAGLWGMADAVWQTQINALYGVLF-PKNKEAAFSNYRLWESLGFVIAFAY 358

                         410       420       430
                  ....*....|....*....|....*....|..
gi 1831510207 642 IRHVTVEIYLLITFFMLLLGMCGFLAIENFDH 673
Cdd:cd17406   359 SNFLCVYVKLYILLAVLLLGMVGYGVVEYIER 390
UNC-93 pfam05978
Ion channel regulatory protein UNC-93; The proteins in this family are represented by UNC-93 ...
 268-666 1.13e-16

Ion channel regulatory protein UNC-93; The proteins in this family are represented by UNC-93 from Caenorhabditis elegans and also includes protein unc-93 homolog A (UNC93A), protein unc-93 homolog B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain- containing protein 11 or protein ET). UNC-93 colocalizes with SUP-10 and SUP-9 within muscle cells. UNC-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons.


Pssm-ID: 461792 [Multi-domain]  Cd Length: 379  Bit Score: 82.37  E-value: 1.13e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 268 SVNGDLGSDSLVALYLSLAISSLFVPSFmINRLGCKLTFLIAIFVYFLYIVINLRPTYSSMIPASIFCGIAASCIWGAKC 347
Cdd:pfam05978   4 GISAYAGYYSLAIIYFFFTFACLIAPSI-VDKLTPKWSMVIGAACYAIFQLGFLFLNSYYLYFSSALLGFGAAFLWTGQG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 348 AYITEmgiryaslNFESQTtvIVRFFGYFFMIVHCGQVVGNMvssYIFTLSYSQalrGPEDSIYDSCGYQFPKNLSDLTE 427
Cdd:pfam05978  83 SYLSE--------NSTRET--IERNTSISWAMLQSSLIGGGI---FLFIVFQSG---GQGDEISDGQIKLLYSVFTAISI 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 428 LAESNLARPPQKVYVAVClaylacviisgmimsmflnalakdARNRKmAQKFnSEIFYLMLKHLINIKFMLLVPLTIFNG 507
Cdd:pfam05978 147 VGIVVFAFLPSPDYENVL------------------------SSKEK-IQSF-ADQFKSTFRLLRTPKMLLLAVFFFYTG 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 508 LEQAFLVGVY------TKAFVGCGLGIwqIGFVMACFGISDAVCSLVFGPL---IKLFGRMPLFVFGAVVNLLMIV---- 574
Cdd:pfam05978 201 LEVSFWTSIYptcisfTSKLGTNTTYL--IAIYSISTGLGQIIGGIFFGPLgkrIRKFGRDPTILLGTLLHLVYFIliyl 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 575 -------------TLMVWPLNAAdtqIFYVVAAMWGMADGVWNTQINGFWVALVGRQSLQfAFTKYRFWESLGIAIGFAL 641
Cdd:pfam05978 279 sfpndaplhptdgPGLLITPSLY---LAFIISFLLGFSDACWNTQIYSILADAYPEDSSQ-AFAVFKFYQSIASCVAFFY 354

                         410       420
                  ....*....|....*....|....*
gi 1831510207 642 IRHVTVEIYLLITFFMLLLGMCGFL 666
Cdd:pfam05978 355 SPYLTLYWHLLILTIFSIFATICFF 379
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
235-637 5.24e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 67.69  E-value: 5.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 235 NKIKRKIMSNLWILSVAFLFLFTAFNGLQNLQTSVNGDLG-SDSLVAL-----YLSLAISSLFVPsFMINRLGCKLTFLI 308
Cdd:COG2814     2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGaSPAQAGLvvtayLLGAALGAPLAG-RLADRFGRRRVLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 309 AIFVYFL-YIVINLRPTYSSMIPASIFCGIAASCIWGAKCAYITEMgiryaslnfeSQTTVIVRFFGYFFMIVHCGQVVG 387
Cdd:COG2814    81 GLLLFALgSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADL----------VPPERRGRALGLLGAGLGLGPALG 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 388 NMVSSYIFTLSysqalrgpedsiydscGYQfpknlsdltelaesnlarppqkvyvAVCLAYLACVIISGMIMSMFLNALA 467
Cdd:COG2814   151 PLLGGLLADLF----------------GWR-------------------------WVFLVNAVLALLALLLLLRLLPESR 189

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 468 KDARNRKMAQkfnseifylmLKHLINIKFMLLvpLTIFNGLEQAFLVGVYTKAFV----GCGLGIWQIGFVMACFGISDA 543
Cdd:COG2814   190 PAARARLRGS----------LRELLRRPRLLL--LLLLAFLLGFGFFALFTYLPLylqeVLGLSASAAGLLLALFGLGGV 257

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 544 VCSLVFGPLIKLFGRMPLFVFGAvvnLLMIVTLMVWPLnAADTQIFYVVAAMWGMADGVWNTQINGFWVALVGRQSLQFA 623
Cdd:COG2814   258 LGALLAGRLADRFGRRRLLLIGL---LLLALGLLLLAL-AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRA 333

                         410
                  ....*....|....
gi 1831510207 624 FTKYRFWESLGIAI 637
Cdd:COG2814   334 SGLYNSAFFLGGPL 347
 
Name Accession Description Interval E-value
MFS_unc93A_like cd17406
Protein unc-93 homolog A and similar proteins of the Major Facilitator Superfamily of ...
 245-673 0e+00

Protein unc-93 homolog A and similar proteins of the Major Facilitator Superfamily of transporters; This subfamily is composed of Caenorhabditis elegans Uncoordinated protein 93 (also called putative potassium channel regulatory protein unc-93), human protein unc-93 homolog A (HmUnc-93A or UNC93A), and similar proteins. Unc-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. The human UNC93A gene is located in a region of the genome that is frequently associated with ovarian cancer, however, there is no evidence that UNC93A has a tumor suppressor function. This unc93A-like subfamily belongs to the Unc-93 family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340964 [Multi-domain]  Cd Length: 390  Bit Score: 551.47  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 245 LWILSVAFLFLFTAFNGLQNLQTSVN--GDLGSDSLVALYLSLAISSLFVPSFMINRLGCKLTFLIAIFVYFLYIVINLR 322
Cdd:cd17406     1 LLVISFAFLLLFTAFQGLQNLQSSLNsdDGLGVVSLSVIYASLIVSCMFLPPLLIKKLGCKWTIVLSMFCYVLYIAANFY 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 323 PTYSSMIPASIFCGIAASCIWGAKCAYITEMGIRYASLNFESQTTVIVRFFGYFFMIVHCGQVVGNMVSSYIFTlsysqa 402
Cdd:cd17406    81 PSWYTLIPASIILGFGAAPLWSAKCTYLTESGNRYAKLTGKSGDDVINRFFGIFFMIFQSSQIWGNLISSLVFS------ 154

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 403 lrgpedsiydscgyqfpknlsdltelaesnlarppQKVYVAVCLAYLACVIISGMIMSMFLNALAKDARNRKMAQKF-NS 481
Cdd:cd17406   155 -----------------------------------QSLIYTLLGIYLGCGILAVIIVAVFLDPLKRDKEKRKQETKFsVL 199

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 482 EIFYLMLKHLINIKFMLLVPLTIFNGLEQAFLVGVYTKAFVGCGLGIWQIGFVMACFGISDAVCSLVFGPLIKLFGRMPL 561
Cdd:cd17406   200 SLLLATFKHLKDPRQLLLIPLTIYSGLEQAFLSGDFTKSYVTCALGIWNVGYVMICFGVVNALCSFLFGRLVKYTGRIPL 279

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 562 FVFGAVVNLLMIVTLMVWPLNAADTQIFYVVAAMWGMADGVWNTQINGFWVALVgRQSLQFAFTKYRFWESLGIAIGFAL 641
Cdd:cd17406   280 FALGALVNLGLIIALLLWEPDPDQLAIFFVFAGLWGMADAVWQTQINALYGVLF-PKNKEAAFSNYRLWESLGFVIAFAY 358

                         410       420       430
                  ....*....|....*....|....*....|..
gi 1831510207 642 IRHVTVEIYLLITFFMLLLGMCGFLAIENFDH 673
Cdd:cd17406   359 SNFLCVYVKLYILLAVLLLGMVGYGVVEYIER 390
MFS_unc93_like cd17338
Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is ...
 247-671 4.85e-74

Unc-93 family of the Major Facilitator Superfamily of transporters; The Unc-93 family is composed of Caenorhabditis elegans uncoordinated protein 93 (also called putative potassium channel regulatory protein unc-93) and similar proteins including three vertebrate members: protein unc-93 homolog A (UNC93A), protein unc-93 homolog B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain-containing protein 11 or protein ET). Unc-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. The human UNC93A gene is located in a region of the genome that is frequently associated with ovarian cancer, however, there is no evidence that UNC93A has a tumor suppressor function. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons. The unc93-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340896 [Multi-domain]  Cd Length: 388  Bit Score: 244.18  E-value: 4.85e-74
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 247 ILSVAFLFLFTAFNGLQNLQTSVN-GDLGSDSLVALYLSLAISSLFVPSFmINRLGCKLTFLIAIFVYFLYIVINLRPTY 325
Cdd:cd17338     3 ILSFGFLLIFLAYSALQNLQTSLHeNGLGSISLGILYSSFAVSSFIAPLL-VKLLGEKITLVLGGLGYAIFIASNIFPIW 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 326 SSMIPASIFCGIAASCIWGAKCAYITEMgiryaslnfeSQTTVIVRFFGYFFMIVHCGQVVGNMVSSYIFTLSYSQalrg 405
Cdd:cd17338    82 GTLVPASIILGFAAAILWTAQGTYITRI----------SDESNIGRNFGIFWSIFQLSQVFGNLISLALLNHSKGS---- 147

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 406 pedsiydscgyqfpknlSDLTELaesnlarppqkvyvavclaYLACVIISGMIMSMFLNALAKDARNRKMAQKFN----- 480
Cdd:cd17338   148 -----------------SGTTIL-------------------FIVFMAIMLVGIILLFFLRGPDNEVITEIESSSvgesm 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 481 --SEIFYLMLKHLINIKFMLLVPLTIFNGLEQAFLVGVYTKAFVGCGLGIWQIGFVMACFGISDAVCSLVFGPLIKL-FG 557
Cdd:cd17338   192 ekKNLFKLPFTLLKDKRFLLLIPLLIYSGLEQTFFSGVFTLIIGTPTTGIARVGYVMAVYGFGDALGSLVAGLLSDWrFG 271

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 558 RMPLFVFGAVVNLLMIVTLMVWPLNAADTQ----IFYVVAAMWGMADGVWNTQINgfwvALVG---RQSLQFAFTKYRFW 630
Cdd:cd17338   272 RIVLAVIGAFVHIASLILLFLSGNVTPYGLggswLAYVSAILWGLGDAIFNTQIY----ALLGslyENDSESAFAVYKLW 347

                         410       420       430       440
                  ....*....|....*....|....*....|....*....|.
gi 1831510207 631 ESLGIAIGFALIRHVTVEIYLLITFFMLLLGMCGFLAIENF 671
Cdd:cd17338   348 QSIATAIAYFLSPYLPLFVKLFVLLALLILLAIFFLFVELK 388
MFS_unc93B1 cd17408
Protein unc-93 homolog B1 of the Major Facilitator Superfamily of transporters; Protein unc-93 ...
 272-669 7.94e-23

Protein unc-93 homolog B1 of the Major Facilitator Superfamily of transporters; Protein unc-93 homolog B1 (UNC93B1) controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. It regulates differential transport of TLR7 and TLR9 into signaling endosomes to prevent autoimmunity. UNC93B1 belongs to the Unc-93 family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340966 [Multi-domain]  Cd Length: 456  Bit Score: 102.17  E-value: 7.94e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 272 DLGSDSLVALYLSLAISSLFVPsFMINRLGCKLTFLIAIFVYFLYIVINLRPTYSSMIPASIFCGIAASCIWGAKCAYIT 351
Cdd:cd17408    43 DIDSKMLMGINVTPIVALLYTP-VLIRFFGTKWMMFLAVGIYALFVSTNYWERYYTLVPSAVAIGVAIVPLWASMGNYIT 121

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 352 EMGIRYAS-LNFESQT-------------TVIVRFFGYFFMIVHCGQVVGNM-----VSSYIFTLSYSqalrgpedsIYD 412
Cdd:cd17408   122 RMAQKYYEyVNYKEEDvqeqkrpprgayhKYIIIFQSVFYAIFHLSFVCAQLpmiffLNNYLYDYNHT---------LYN 192

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 413 --SCGYQFPKNLSDLTELAESNLARPPQKVYVAVCL---AYLACVIISGMIMSMFLNALAKDARNRKMAQkfnseIFYLM 487
Cdd:cd17408   193 vkHCGAQSKGILEGFNKTVLITLPRSLNLIIVESALmgaAFLSMLLVLLLCGAAYRPTEEIDLRSIGWGN-----IFQLP 267

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 488 LKHLINIKFMLLVPLTIFNGLEQAFLVGVYTKAFVGCGLGIWQIGFVMACFGISDAVCSLVFGPLIKLFGRMPLfVFGAV 567
Cdd:cd17408   268 FKHLRDYRLRLLIPFFIYSGFEVLFACTGFALSYGVCSLGLERLAYLLMAYGLSASLCSLLALSLLRLPRPVPL-VAGAF 346

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 568 VNLLMIVTLMVWPLNAADTQ---IFYVVAAMWGMADGVWNTQINgfwvALVG-----RQSLQFAFTKYRFWESLGIAIGF 639
Cdd:cd17408   347 LHLTLLITLFFWAPTPRLTSqmpLLYVVAALWGLGSALNKTGLS----TLLGilyedKERQDFIFTIYHWWQALAIFIVY 422

                         410       420       430
                  ....*....|....*....|....*....|
gi 1831510207 640 aLIRHVTVEIYLLITFFMLLLGMCGFLAIE 669
Cdd:cd17408   423 -LWSNLPMKAKLGILLATLVIALLSYLWME 451
MFS_MFSD11 cd17407
UNC93-like Major facilitator superfamily domain-containing protein 11; This group is composed ...
 247-669 3.63e-20

UNC93-like Major facilitator superfamily domain-containing protein 11; This group is composed of UNC93-like protein MFSD11 (also called major facilitator superfamily domain-containing protein 11 or protein ET) and similar proteins, most of which are uncharacterized. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons. Its expression is affected by altered energy homeostasis, suggesting plausible involvement in the energy regulation. MFSD11 belongs to the Unc-93 family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340965  Cd Length: 387  Bit Score: 93.09  E-value: 3.63e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 247 ILSVAFLFLFTAFNGLQNLQTSVNGDL----------GSDSLVALYLSLAISSLFVPSFmINRLGCKLTFLIAIFVYFLY 316
Cdd:cd17407     3 ILGVAFMFIFTAFQTCGNIEQTVIKSLnqgnttfhgsGYTSLAIIYGVFAASNWIAPSV-VAVIGPKWSMVVGGLTYSLF 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 317 IVINLRPTYSSMIPASIFCGIAASCIWGAKCAYITEmgiryaslNFESQTtvIVRFFGYFFMIVHCGQVVGNMvssYIFT 396
Cdd:cd17407    82 IASFIQPMTWSLYTASVLLGIGAAVLWTGQGNFLTI--------NSDSET--IGRNSGIFWALLQCSLLFGNL---YVYF 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 397 lsysqALRGpEDSIYDSCGYQfpknlsdltelaesnlarppqkVYVAVClayLACVIisGMIMSMFLNALAKDARNrkma 476
Cdd:cd17407   149 -----AFQG-KTTISDHDRRT----------------------VFIVLT---VISLV--GVVLLFLLRKPPSEPKE---- 191

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 477 qkfnseifylmlkhlinikfMLLVPLTIF-NGLEQAFLVGVYTKAfVGCGLGIWQ-----IGFVMACFGISDAVCSLVFG 550
Cdd:cd17407   192 --------------------MLLLSVTFAyTGLELTFFSGVYGTC-IGNTNKFGEdakslIGLSGIFIGIGEILGGGLFG 250

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 551 PLIK---LFGRMPLFVFGAVVNLLMIV-TLMVWPLNAA---DTQIFY----------VVAAMWGMADGVWNTQINGFWVA 613
Cdd:cd17407   251 ILGKktnRFGRDPIVLLGFVVHLIAFYlIFLNIPSDAPiaeGTNDSAyiepsayvalFCSFLLGFGDSCFNTQIYSILGF 330

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1831510207 614 LVGRQSLQfAFTKYRFWESLGIAIGFALIRHVTVEIYLLITFFMLLLGMCGFLAIE 669
Cdd:cd17407   331 MYPEDSAP-AFALFKFVQSIAAAIAFFYSNYLLLQWQLLILVVFGFLGTISFFLVE 385
UNC-93 pfam05978
Ion channel regulatory protein UNC-93; The proteins in this family are represented by UNC-93 ...
 268-666 1.13e-16

Ion channel regulatory protein UNC-93; The proteins in this family are represented by UNC-93 from Caenorhabditis elegans and also includes protein unc-93 homolog A (UNC93A), protein unc-93 homolog B1 (UNC93B1), and UNC93-like protein MFSD11 (also called major facilitator superfamily domain- containing protein 11 or protein ET). UNC-93 colocalizes with SUP-10 and SUP-9 within muscle cells. UNC-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. UNC93B1 controls intracellular trafficking and transport of a subset of Toll-like receptors (TLRs), including TLR3, TLR7 and TLR9, from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. MFSD11 is ubiquitously expressed in the periphery and the central nervous system of mice, where it is expressed in excitatory and inhibitory mouse brain neurons.


Pssm-ID: 461792 [Multi-domain]  Cd Length: 379  Bit Score: 82.37  E-value: 1.13e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 268 SVNGDLGSDSLVALYLSLAISSLFVPSFmINRLGCKLTFLIAIFVYFLYIVINLRPTYSSMIPASIFCGIAASCIWGAKC 347
Cdd:pfam05978   4 GISAYAGYYSLAIIYFFFTFACLIAPSI-VDKLTPKWSMVIGAACYAIFQLGFLFLNSYYLYFSSALLGFGAAFLWTGQG 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 348 AYITEmgiryaslNFESQTtvIVRFFGYFFMIVHCGQVVGNMvssYIFTLSYSQalrGPEDSIYDSCGYQFPKNLSDLTE 427
Cdd:pfam05978  83 SYLSE--------NSTRET--IERNTSISWAMLQSSLIGGGI---FLFIVFQSG---GQGDEISDGQIKLLYSVFTAISI 146

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 428 LAESNLARPPQKVYVAVClaylacviisgmimsmflnalakdARNRKmAQKFnSEIFYLMLKHLINIKFMLLVPLTIFNG 507
Cdd:pfam05978 147 VGIVVFAFLPSPDYENVL------------------------SSKEK-IQSF-ADQFKSTFRLLRTPKMLLLAVFFFYTG 200

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 508 LEQAFLVGVY------TKAFVGCGLGIwqIGFVMACFGISDAVCSLVFGPL---IKLFGRMPLFVFGAVVNLLMIV---- 574
Cdd:pfam05978 201 LEVSFWTSIYptcisfTSKLGTNTTYL--IAIYSISTGLGQIIGGIFFGPLgkrIRKFGRDPTILLGTLLHLVYFIliyl 278

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 575 -------------TLMVWPLNAAdtqIFYVVAAMWGMADGVWNTQINGFWVALVGRQSLQfAFTKYRFWESLGIAIGFAL 641
Cdd:pfam05978 279 sfpndaplhptdgPGLLITPSLY---LAFIISFLLGFSDACWNTQIYSILADAYPEDSSQ-AFAVFKFYQSIASCVAFFY 354

                         410       420
                  ....*....|....*....|....*
gi 1831510207 642 IRHVTVEIYLLITFFMLLLGMCGFL 666
Cdd:pfam05978 355 SPYLTLYWHLLILTIFSIFATICFF 379
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 248-668 7.81e-16

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 79.78  E-value: 7.81e-16
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 248 LSVAFLFLFTAFNGLQNLQTSVNGDLG-SDSLVALYLSL-----AISSLFVpSFMINRLGCKLTFLIAIFVYFLYIVINL 321
Cdd:cd06174     1 LLLGFFLTGLARGLISPLLPALLQSFGlSASQLGLLFALfslgyALLQPLA-GLLADRFGRRPVLLLGLLLFALGALLFA 79

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 322 RPT-YSSMIPASIFCGIAASCIWGAKCAYITEMgiryaslnfeSQTTVIVRFFGYFFMIVHCGQVVGnMVSSYIFTLSYS 400
Cdd:cd06174    80 FAPsFWLLLLGRFLLGLGSGLIDPAVLALIADL----------FPERERGRALGLLQAFGSVGGILG-PLLGGILASSLG 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 401 QALRgpedsiydscgyqfpknlsdltelaesnlarppqkvyvAVCLAYLACVIISGMIMSMFLNALAKDARNRKMAQKFn 480
Cdd:cd06174   149 FGWR--------------------------------------AVFLIAAALALLAAILLLLVVPDPPESARAKNEEASS- 189

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 481 SEIFYLMLKHLINIKFMLLVPL-TIFNGLEQAFLVGVYTKAFVGCGLGIWQIGFVMACFGISDAVCSLVFGPLI-KLFGR 558
Cdd:cd06174   190 KSVLKLLKRVLKNPGLWLLLLAiFLVNLAYYSFSTLLPLFLLDLGGLSVAVAGLLLSLFGLAGALGSLLLGLLSdRLIGR 269

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 559 MPLFVFGavvnLLMIVTLMVWPLNAADTQIFYVVAAMWGMADGVWNTQINGFWVALVGRQSLQFAFTKYRFWESLGIAIG 638
Cdd:cd06174   270 KPLLLIG----LLLMALGLALLLLAPSLLLLLLLLLLLGFGLGGLLPLSFALIAELFPPEIRGTAFGLLNTFGFLGGAIG 345

                         410       420       430
                  ....*....|....*....|....*....|
gi 1831510207 639 FALIRHVTVEIYLLITFFMLLLGMCGFLAI 668
Cdd:cd06174   346 PLLAGFLLAATFGLTGAFLVLAVLLLLAAI 375
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
235-637 5.24e-12

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 67.69  E-value: 5.24e-12
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 235 NKIKRKIMSNLWILSVAFLFLFTAFNGLQNLQTSVNGDLG-SDSLVAL-----YLSLAISSLFVPsFMINRLGCKLTFLI 308
Cdd:COG2814     2 PATPRRRWLALLALALGAFLSGLGIGIVLPALPLIAADLGaSPAQAGLvvtayLLGAALGAPLAG-RLADRFGRRRVLLL 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 309 AIFVYFL-YIVINLRPTYSSMIPASIFCGIAASCIWGAKCAYITEMgiryaslnfeSQTTVIVRFFGYFFMIVHCGQVVG 387
Cdd:COG2814    81 GLLLFALgSLLCALAPSLWLLLAARFLQGLGAGALFPAALALIADL----------VPPERRGRALGLLGAGLGLGPALG 150

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 388 NMVSSYIFTLSysqalrgpedsiydscGYQfpknlsdltelaesnlarppqkvyvAVCLAYLACVIISGMIMSMFLNALA 467
Cdd:COG2814   151 PLLGGLLADLF----------------GWR-------------------------WVFLVNAVLALLALLLLLRLLPESR 189

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 468 KDARNRKMAQkfnseifylmLKHLINIKFMLLvpLTIFNGLEQAFLVGVYTKAFV----GCGLGIWQIGFVMACFGISDA 543
Cdd:COG2814   190 PAARARLRGS----------LRELLRRPRLLL--LLLLAFLLGFGFFALFTYLPLylqeVLGLSASAAGLLLALFGLGGV 257

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 544 VCSLVFGPLIKLFGRMPLFVFGAvvnLLMIVTLMVWPLnAADTQIFYVVAAMWGMADGVWNTQINGFWVALVGRQSLQFA 623
Cdd:COG2814   258 LGALLAGRLADRFGRRRLLLIGL---LLLALGLLLLAL-AGSLWLLLLALFLLGFGFGLLFPLLQALVAELAPPEARGRA 333

                         410
                  ....*....|....
gi 1831510207 624 FTKYRFWESLGIAI 637
Cdd:COG2814   334 SGLYNSAFFLGGPL 347
MFS_1 pfam07690
Major Facilitator Superfamily;
245-638 1.32e-11

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 66.67  E-value: 1.32e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 245 LWILSVAFLFLFTAFNGLqnLQTSVNGDLGSDS-----LVALYLSLAISSLFVPSFMINRLGCKLTFLIAIFVYFL-YIV 318
Cdd:pfam07690   1 LFLAAFLAALGRSLLGPA--LPLLLAEDLGISPteiglLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALgLLL 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 319 INLRPTYSSMIPASIFCGIAASCIWGAKCAYITEMgiryaslnfeSQTTVIVRFFGYFFMIVHCGQVVGNMVSSYIFTLS 398
Cdd:pfam07690  79 LLFASSLWLLLVLRVLQGLGAGALFPAALALIADW----------FPPEERGRALGLVSAGFGLGAALGPLLGGLLASLF 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 399 YSQAlrgpedsiydscgyqfpknlsdltelaesnlarppqkVYVAVCLAYLACVIIsgmimsMFLNALAKDARNRKMAQK 478
Cdd:pfam07690 149 GWRA-------------------------------------AFLILAILSLLAAVL------LLLPRPPPESKRPKPAEE 185

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 479 FNSEIFYLMLKHLINIKFMLLVPLTIFNGLEQAFLVGVYTKAFVgCGLGIWQIGFVMACFGISDAVCSLVFGPLIKLFGR 558
Cdd:pfam07690 186 ARLSLIVAWKALLRDPVLWLLLALLLFGFAFFGLLTYLPLYQEV-LGLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGR 264

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 559 MPLFVFGAVVnLLMIVTLMVWPLNAADTQIFYVVAAMWGMADGVWNTQINGFWVALVGRQSLQFAFTKYRFWESLGIAIG 638
Cdd:pfam07690 265 RRRLLLALLL-LILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFPALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 278-638 3.16e-11

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 65.68  E-value: 3.16e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 278 LVALY-LSLAISSLFVpSFMINRLGCKLTFLIAIFVYFL-YIVINLRPTYSSMIPASIFCGIAASCIWGAKCAYITEMgi 355
Cdd:cd17325    36 IVAAYaLAQLLFSPPA-GRLSDRFGRKRLLLLGLLLLAVsTLLFAFATSYWQLLLARFLQGLASAAVWPAAMALIADI-- 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 356 ryaslnfeSQTTVIVRFFGYFFMIVHCGQVVGNMVSSYiftlsysqalrgpedsIYDSCGYQFPknlsdltelaesnlar 435
Cdd:cd17325   113 --------APPEERGRAMGIFSSAIGLGFLIGPLLGGL----------------LADALGYRAP---------------- 152

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 436 ppqkvYVAVCLAYLACVIISGMIMSmflNALAKDARNRKMAQKFNSEIFYLMLKHLINIKFMLLVPLTIFNGLEQAFLvG 515
Cdd:cd17325   153 -----FLVCAALALLALVLALLLLP---EPRPPPNKRAVSAARLRSGLRLLLRDRRLLALFLAIFVLAFAFGALEPFL-P 223

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 516 VYTKAFVgcGLGIWQIGFVMACFGISDAVCSLVFGPLIKLFGRMPLFVFGAvvnLLMIVTLMVWPLnAADTQIFYVVAAM 595
Cdd:cd17325   224 LYAAELG--GLSPAQIGLLFGAQGLASALSQPPAGKLSDRIGRKPLILIGL---LLSAVALLLLPL-ATSFWLLLLLLAL 297

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|...
gi 1831510207 596 WGMADGVWNTQINGFWVALVGRQSLQFAFTKYRFWESLGIAIG 638
Cdd:cd17325   298 LGLGLGLVFPATLALLADIVPPEGRGTAMGLFNTAFSLGMVLG 340
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
242-604 3.03e-07

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 53.35  E-value: 3.03e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 242 MSNLWILSVAFLFLFTAFNGLQNLQTSVNGDLG-SDS----LVALY-LSLAISSLFVpSFMINRLGCKLTFLIAIFVYFL 315
Cdd:COG2223     4 WRVLLLATLAFFLAFGVWYLWSVLAPPLAEEFGlSAAqlglLFAIPvLVGALLRIPL-GFLVDRFGPRRVLLIGLLLLGI 82

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 316 -YIVINLRPTYSSMIPASIFCGIAASCIWGAkcayitemGIRYASLNFESQTtvivrfFGYFFMIVHCGQVVGNMVSSYI 394
Cdd:COG2223    83 gLLLLALAVSYWLLLLLGLLLGIGGGGSFAV--------GIALVSKWFPPDR------RGLALGLAAGGGNLGAAVAAFL 148

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 395 FTLsysqalrgpedsIYDSCGYQfpknlsdltelaesnlarppqkvyvAVCLAYLACVIISGMIMSMFLNALAKDARNrk 474
Cdd:COG2223   149 APL------------LIAAFGWR-------------------------NAFLILGILLLVVAVLAWLFLRDPPAGAAA-- 189

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 475 mAQKFNSEIFYLMLKHLINIKFMLLVPLTIFNGLE-QAFLVGVYTKAFvgcGLGIWQIGFVMACFGISDAVCSLVFGPLI 553
Cdd:COG2223   190 -AAKASLRDQLEALRDPRFWLLSLLYFGTFGSFIGfSSWLPPYLVDQF---GLSAATAGLLAALFALLGALGRPLGGWLS 265

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|.
gi 1831510207 554 KLFGRMPLFVFGAVVNLLMIVTLMVWPLNAAdtqIFYVVAAMWGMADGVWN 604
Cdd:COG2223   266 DRIGGRRVLLIVFALMALGLLLLALALGSLW---LFLVLFLLLGLALGGGN 313
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 525-668 4.80e-07

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 52.61  E-value: 4.80e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 525 GLGIWQIGFVMACFGISDAVCSLVFGPLIKLFGRMPLFVFGAVVNLLMIVTLMVwplnAADTQIFYVVAAMWGMADGVWN 604
Cdd:cd17329    31 GLSASIVGLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGF----AHSPWLFAIALVLTGFGGGLFE 106

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1831510207 605 TQINGFWVALVGRQSLQFAFTKYRFWESLGIAIGFALIRHVTVEIYLLItfFMLLLGMCGFLAI 668
Cdd:cd17329   107 PASEAMIADVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLL--FLAAAVLFLLAAL 168
MFS_1 pfam07690
Major Facilitator Superfamily;
530-673 6.96e-07

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 52.04  E-value: 6.96e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 530 QIGFVMACFGISDAVCSLVFGPLIKLFGRMPLFVFGAVVNLLMIVTLMVwplnAADTQIFYVVAAMWGMADGVWNTQING 609
Cdd:pfam07690  33 EIGLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF----ASSLWLLLVLRVLQGLGAGALFPAALA 108

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 1831510207 610 FWVALVGRQSLQFAFTKYRFWESLGIAIGFALIRHVTVE-----IYLLITFFMLLLGMCGFLAIENFDH 673
Cdd:pfam07690 109 LIADWFPPEERGRALGLVSAGFGLGAALGPLLGGLLASLfgwraAFLILAILSLLAAVLLLLPRPPPES 177
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
525-641 1.16e-06

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 51.13  E-value: 1.16e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 525 GLGIWQIGFVMACFGISDAVCSLVFGPLIKLFGRMPLFVFGAVVNLLMIVTLMVWPlnaaDTQIFYVVAAMWGMADGVWN 604
Cdd:COG2814    41 GASPAQAGLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCALAP----SLWLLLAARFLQGLGAGALF 116

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1831510207 605 TQINGFWVALVGRQSLQFAFTKYRFWESLGIAIGFAL 641
Cdd:COG2814   117 PAALALIADLVPPERRGRALGLLGAGLGLGPALGPLL 153
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
278-580 3.14e-05

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 46.77  E-value: 3.14e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 278 LVALYLSLAISSLFVpSFMINRLGCKLTFLIAIFVYFL-YIVINLRPTYSSMIPASIFCGIAASCIWGAKCAYITEMGIR 356
Cdd:COG0738    49 LFAFFLGYLLASLPA-GRLIDRFGYKRGLLLGLLLMALgLLLFALAPSYPLLLLALFLLGLGLGLLDVAANPYVAALGPE 127

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 357 YAslnfesqtTVIVRFFGYFFMIvhcGQVVGNMVSSYIFTLSYSQALRGPedsiydscgyqfpknlsdltelaesnlarp 436
Cdd:COG0738   128 TA--------ASRLNLLHAFFSL---GALLGPLLGGLLILLGLSLSWHLP------------------------------ 166

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 437 pqkvYVAVCLAYLACVIIsgmIMSMFLNALAKDARNRKMAQKfnseifylMLKHLINIKFMLLVPLTIF--NGLEQAFL- 513
Cdd:COG0738   167 ----YLILAVLLLLLALL---FLRSKLPEIEEEEEEAAGSAA--------SLKSLLKNPRLLLGGLAIFlyVGAEGAIGd 231

                         250       260       270       280       290       300
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1831510207 514 -VGVYTKAFVgcGLGIWQIGFVMACFGISDAVCSLVFGPLIKLFGRMPLFVFGAVVNLLMIVTLMVWP 580
Cdd:COG0738   232 wLPLYLKDVL--GLSEATAALGLSLFWGGMTIGRFLGGFLLKRFGPVRLLRLSALLAAVGLLLALLAP 297
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 525-641 5.23e-05

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 46.03  E-value: 5.23e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 525 GLGIWQIGFVMACFGISDAVCSLVFGPLIKLFGRMPLFVFGAVvnLLMIVTLMVwpLNAADTQIFYVVAAMWGMADGVWN 604
Cdd:cd17325    27 GASVAQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLL--LLAVSTLLF--AFATSYWQLLLARFLQGLASAAVW 102

                          90       100       110
                  ....*....|....*....|....*....|....*..
gi 1831510207 605 TQINGFWVALVGRQSLQFAFTKYRFWESLGIAIGFAL 641
Cdd:cd17325   103 PAAMALIADIAPPEERGRAMGIFSSAIGLGFLIGPLL 139
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 440-667 1.07e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 45.30  E-value: 1.07e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 440 VYVAVCLAYLACVIISgmimsMFLNALAKDARNRKMAQKFNSEIFYLMLKHLINIKFMLLVPLTIFNGLEQAFLVGVYTK 519
Cdd:cd06173   160 AFAINALSFLLSALLL-----LFIRRPPPAAPGESSSLLLRDLREGLRYLRRSPLLRLLLLALALFALLGGALTVLLPLL 234

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 520 AFVGCGLGIWQIGFVMACFGISDAVCSLVFGPLIKLFGRMPLFVFGAVVN----LLMIVTLMVWplnaadtqIFYVVAAM 595
Cdd:cd06173   235 AKEVLGGGAAGYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLglalLVLGLSPSLW--------LLLAALFL 306

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1831510207 596 WGMADGVWNTQINGFW-----VALVGRqslqfAFTKYRFWESLGIAIGFALIRHVTVEIYLLITFfmLLLGMCGFLA 667
Cdd:cd06173   307 LGLAGGLFNVPLNTLLqlrvpDELRGR-----VFSVYNALNSGAMPLGALLAGLLADALGLSAVF--LLAGALLLLA 376
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
524-662 1.75e-04

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 44.46  E-value: 1.75e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 524 CGLGIWQIGFVMACFGISDAVCSLVFGPLIKLFGRMPLFVFGAvvnLLMIVTLMVwPLNAADTQIFYVVAAMWGMADGVW 603
Cdd:COG0738    38 FGLSDAQAGLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGL---LLMALGLLL-FALAPSYPLLLLALFLLGLGLGLL 113

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 1831510207 604 NTQINGFwVALVGRQSLQFAFTKYRFWESLGIAIG-----FALIRHVTVEI---YLLITFFMLLLGM 662
Cdd:COG0738   114 DVAANPY-VAALGPETAASRLNLLHAFFSLGALLGpllggLLILLGLSLSWhlpYLILAVLLLLLAL 179
MFS_unc93-like cd06178
Uncharacterized Unc-93-like proteins of the Major Facilitator Superfamily of transporters; ...
 250-401 2.96e-03

Uncharacterized Unc-93-like proteins of the Major Facilitator Superfamily of transporters; This subfamily consists of uncharacterized proteins, mainly from fungi and plants, with similarity to Caenorhabditis elegans uncoordinated protein 93 (also called putative potassium channel regulatory protein unc-93). Unc-93 acts as a regulatory subunit of a multi-subunit potassium channel complex that may function in coordinating muscle contraction in C. elegans. The unc93-like subfamily belongs to the Unc-93 family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340867  Cd Length: 415  Bit Score: 40.74  E-value: 2.96e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 250 VAFLF--LFTAFNGLQNlQTSVNGDLGSDSLVALYLSLAISSLFVPSFmINRLGCKLTFLIAIFVYFLYI----VINLRP 323
Cdd:cd06178     9 VCFCCpgMFNALTGLGG-GGQVDPTVANNANTALYATFAVFGFFGGGI-FNLLGPRLTLAFGGTGYPLYAgsllSYNHVQ 86

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 1831510207 324 TYSSMIPASIFCGIAASCIWGAKCAYITEmgirYASlnfESQTTvivRFFGYFFMIVHCGQVVGNMVSsyiFTLSYSQ 401
Cdd:cd06178    87 NQGFVIFAGAILGIGAGLLWTAQGAIMLS----YPT---ENQKG---RFIAIFWVIFNLGGVIGSLIP---FGLNYHS 151
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
239-398 3.53e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 40.27  E-value: 3.53e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 239 RKIMSN--LWILSVAFLFLFTAFNGLQNLQ----TSVNGDlgSDSLVALYLSL-----AISSLFVPsFMINRLGCKLTFL 307
Cdd:COG2211   222 KALLKNrpFLLLLLAYLLFFLALALVAALLlyyfKYVLGL--SAALVGLLLALyflaaLLGAPLWP-RLAKRFGKKKAFI 298

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 308 IAIFV----YFLYIVINLRPTYSSMIpASIFCGIAASCIWGAKCAYITEMgIRYASLNFESQTTVIvrFFGYFFMIVHCG 383
Cdd:COG2211   299 IGLLLaalgLLLLFFLGPGNLWLLLV-LAALAGIGLGAILVLPWAMLADV-VDYDEWKTGRRREGL--YFGIFTFAIKLG 374

                         170
                  ....*....|....*
gi 1831510207 384 QVVGNMVSSYIFTLS 398
Cdd:COG2211   375 QALAGALAGLLLALF 389
MFS_MCT_SLC16 cd17352
Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; ...
 479-638 4.95e-03

Monocarboxylate transporter (MCT) family of the Major Facilitator Superfamily of transporters; The animal Monocarboxylate transporter (MCT) family is also called Solute carrier family 16 (SLC16 or SLC16A). It is composed of 14 members, MCT1-14. MCTs play an integral role in cellular metabolism via lactate transport and have been implicated in metabolic synergy in tumors. MCT1-4 are proton-coupled transporters that facilitate the transport across the plasma membrane of monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and ketone bodies such as acetoacetate, beta-hydroxybutyrate and acetate. MCT8 and MCT10 are transporters which stimulate the cellular uptake of thyroid hormones such as thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine (T2). MCT10 also functions as a sodium-independent transporter that mediates the uptake or efflux of aromatic acids. Many members are orphan transporters whose substrates are yet to be determined. The MCT family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340910 [Multi-domain]  Cd Length: 361  Bit Score: 39.84  E-value: 4.95e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 479 FNSEIFYLMLKHLINIKFMLLV------PLTIFNGLeqaFLVGVYTKAFvgcGLGIWQIGFVMACFGISDAVCSLVFGpL 552
Cdd:cd17352   168 LNLCVCGLLLRLLKDPTFVLLAlgvsfaMLGFFVPF---VYLPSYAKSL---GIDESDAAFLLSIIGISDIVGRILLG-L 240

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 553 IKLFGRMPLFVFGAVVNLLMIVTLMVWPLnAADTQIFYVVAAMWGMADGVWNTQINGFWVALVGRQSLQFAFTKYRFWES 632
Cdd:cd17352   241 LADKPRIGRLYLYIFTLLILGLSLLAFPL-ATTYVGLIVFSVLFGFCSGSYSSLTPVILADLVGLEKLSNAYGLVLLFQG 319


                  ....*.
gi 1831510207 633 LGIAIG 638
Cdd:cd17352   320 LAALVG 325
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 531-668 5.76e-03

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 39.41  E-value: 5.76e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 531 IGFVMACFGISDAVCSLVFGPLIKLFGRMPLFVFGAVVNLLMIVTLMVWPLNAADTQI--FYVVAAMWGMADGVWNTQIN 608
Cdd:COG0477   140 LGLWGAAIGLGLALGPLLGGLLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLAllALALAALLLAALALALLALL 219

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 609 GFWVALVGRQSLQFAFTKYRFWESLGIAIGFALIRHVTVEIYLLITFFMLLLGMCGFLAI 668
Cdd:COG0477   220 LLLLLLLLALLALLLAGAALLLLLALLLLALLLLLALLLLAALLLLLLLLLLLALLLALL 279
MFS_MMR_MDR_like cd17504
Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) ...
 520-599 5.85e-03

Methylenomycin A resistance protein (also called MMR peptide)-like multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This subfamily is composed of putative multidrug resistance (MDR) transporters including Chlamydia trachomatis antiseptic resistance protein QacA_2, and Serratia sp. DD3 Bmr3. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. This subfamily belongs to the Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters (MMR-like MDR transporter) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341047 [Multi-domain]  Cd Length: 371  Bit Score: 39.48  E-value: 5.85e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 520 AFVGCGLGIWQIGFVMACFGISDAVCSLVFGPLIKLFGRMPLFVFGAVVNLLMIVTLMVWPLNAADTQIFYVVAAMwGMA 599
Cdd:cd17504   208 TPTGFGLGITEAGLLLLPGALVMLIAGPLAGRLIARVGPRRVLLIGLVISAVGLLLLALLHSSLWALVVALLLIGI-GLG 286
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 241-362 6.92e-03

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 39.12  E-value: 6.92e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 241 IMSNLWILSVAFLFLFTAFNGLQNLQTSV-NGDLGSDSLVALYLSLAISSLFVPS-----FMINRLGCKLTFLI-----A 309
Cdd:cd17316   175 LRRRTLLLILLWFFISFGYYGLTTFLPTYlQTVLGLSPATSSLYLLLISLGALVGaliagLLSDRIGRKKTLVIglilsG 254

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 1831510207 310 IFVYFLYIVINLRPTYssMIPASIFCGIAASCIWGAKCAYITEM---GIRYASLNF 362
Cdd:cd17316   255 ILALPLFYLLSGSPTL--LLLLLFILSFFVGGVWGALYAYLAELfptEVRATGVGL 308
MFS_MJ1317_like cd17370
MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed ...
 525-605 8.41e-03

MJ1317 and similar transporters of the Major Facilitator Superfamily; This family is composed of Methanocaldococcus jannaschii MFS-type transporter MJ1317, Mycobacterium bovis protein Mb2288, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340928 [Multi-domain]  Cd Length: 371  Bit Score: 39.06  E-value: 8.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1831510207 525 GLGIWQIGFVMACFGISDAVCSLVFGPLIKLFGRMPLFVFGAvvnLLMIVTLMVWPLNAADTQIFyVVAAMWGMADGVWN 604
Cdd:cd17370   230 GLSAALIPLLYALFNLVYALAAYPAGRLSDRIGRKKLLILGY---LSLALAYLGFALGSSLWLLL-LGFILWGLYMGAQE 305


                  .
gi 1831510207 605 T 605
Cdd:cd17370   306 S 306
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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